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1st Hands-on Computational Enzyme Design Course

February 2-5 2020, Brno, Czech Republic

About the course

Do you need to engineer your protein of interest? Do you wish to employ user-friendly one-stop-shop software tools for the design of mutations and libraries, but do not want to spend time on tedious installations? This three-day interactive course will provide the essential theory and hands-on experience on a number of web-based tools suitable for enzyme mining and engineering activity, specificity, enantioselectivity, stability, and solubility.

You will have the chance to discuss with the developers of these tools the optimal way to set-up calculations and adequately interpret the results. Special time will be devoted to the proteins of interest of the individual participants. At the end of this three-day course, you will be able to independently design proteins for your academic research or commercial application.

Covered software: AutoDock, Blast, Caver, Caver Analyst, CaverDock, CaverWeb, CalFitter, EnzymeMiner, FireProt, HotSpot Wizard, Rosetta, Solubis, SoluProt, Yasara, and VMD. Our web tools integrate individual software, and altogether, you will get automated access to more than 50 computational methods and 15 databases.

Who should participate

The course is primarily meant for protein and metabolic engineers with no prior experience in computer modeling and bioinformatics. The experts willing to broaden their current computational protein design toolbox will also benefit from this course. Doctoral students, postdocs, and staff members from both academia and companies are welcome.

Three pillars of the course


Theoretical lectures will cover the scientific background and state-of-the-art. The essence of each field required to understand the theory behind the studied tools will be presented.


„Learning by doing“ is the most efficient and enjoyable way to learn. The tool developers will guide you individually through the tutorials, interact, and discuss.


It is pleasant and useful to meet peers working on similar research topics from all over the world. Instant networking will take place during the joint activities and meals.


Barbora Kozlíková
Biomolecular visualisations
David Bednář
Mining novel enzymes in databases
Gaspar Pinto
Molecular dynamics simulations
Jan Štourač
Design of mutations and smart libraries
Jiří Damborský
computational enzyme design
Jiří Filipovič
High-performance computing
Jiří Hon
engineering protein solubility
Joan Planas-Iglesias
sequence similarity search strategies
Miloš Musil
engineering of protein stability
Ondřej Vávra
Design enzyme tunnels and channels
Sérgio Marques
Engineering catalytic activity
Stanislav Mazurenko
design by machine learning



The course will start on Sunday afternoon with the registration (February 2nd, 2020), and will close with the graduation dinner on Wednesday evening (February 5th, 2020).

Nothing to show.


The course will take place at the University Campus Bohunice, Masaryk University, Brno, Czech Republic.

Day 1 (Sunday) : INBIT conference room (ground floor), Kamenice 34, 625 00, Brno.

Day 2 – 4 (Monday-Wednesday): RECETOX computer room no. 347, Masaryk University Campus Bohunice, Kamenice 753/5, pavilion A29, 625 00, Brno.


Use this form to register. Early-bird discounts apply. The invoice will be issued based on the information provided during the registration.

The course is limited to 30 participants, prioritized based on their registration order. Do not miss your chance and register now! The registrations will be open between October 9th and December 16th, 2019.

Till November 30850 EUR1650 EUR
Till December 161150 EUR2250 EUR

The registration fee includes:

  • course materials
  • welcome reception
  • graduation dinner
  • all lunches
  • coffee breaks
  • guided tour with dinner
  • a museum visit with dinner

The fee does not cover accommodation and breakfasts.


The participants are kindly requested to make arrangements for their own accommodation.

15 double-bed rooms are pre-booked in the Campea Aparthotel***, which is located within walking distance from the venue. The rooms will be pre-booked till January 5th. Preferably, the double rooms should be used for two people where possible. Please book your accommodation using the online reservation form, providing the code ACADEMY in the field Additional information.

Other hotels located near the University Campus Bohunice: Hotel Myslivna***, Park Hotel***, Orea Hotel Voronez****, Penzion Levandule, Dormitory Garni Hotel.


This campus is known to be the largest project in the domain of university education in Central Europe. The campus hosts the Faculty of Science and Faculty of Medicine under a single roof. The course will be running in a modern computational laboratory with the necessary facilities.

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Situated on the outskirts of the city, Campea Aparthotel offers accommodation in comfortable double rooms with the modern equipment and views of the city. The bus stop “Univerzitní Kampus” is 100 m away. The on-site restaurant serves Czech and international cuisine. Several shops and grocery stores are within a range of 400 m.

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Brno city

The second-largest city in the Czech Republic. Fourteen universities and 90 000 students make it a pulsing „organism“. Brno is a city of reach culture, beautiful architecture, many coffee houses, restaurants, and green parks. Brno is 6th most attractive city for students, according to the world-ranking.

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