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Jan Mičan

Protein-Protein Interface Design

A freshly graduated medical doctor is now continuing his six-year-long research project developing thrombolytic proteins against ischemic stroke and studying neurological disorders. He was working on computer-aided rational design of mutants of human thrombolytic alteplase and bacterial thrombolytic staphylokinase during his studies, where he was designing their interactions both for improving affinity and for cancelling unwanted interactions. He currently studies and works as a PhD student at Loschmidt Laboratories, aimed at molecular modeling and bioinformatics in neurological diseases, focusing on stroke, Alzheimer’s disease, and epilepsy. He also engineered fluorine biochemistry pathways and PET biocatalysts. His methodological focus is shifting to molecular dynamics methods such as metainference or adaptively steered MD. He has published ten research articles with a total of 80 citations, won the prizes of the Dean and the student’s scientific conference, and stayed at Sarel Fleishman’s lab in Weizmann’s Institute in Israel and Michele Vendruscolo’s group in Cambridge.

LinkedIn: https://www.linkedin.com/in/jan-mičan-4aaa94226/
ResearchGate: https://www.researchgate.net/profile/Jan-Mican