She is doing her Ph.D. studies in Molecular modeling since 2021 when she obtained her MSc in Bioinformatics, both at Masaryk University (Brno, CZ). During her Master’s studies (2019 – 2021), she was in the field of in silico protein stabilization, using tools such as Rosetta ddg_monomer, FoldX, and FireProt to calculate the effect of mutations on protein stability. She focused on testing the reliability of the different protein stability predictors on a recently published database of experimental stability data called FireProtDB, which she helped develop. Currently, her main research interest is studying bioluminescent enzymes called luciferases by adaptive molecular dynamics simulations and ligand docking methods, to learn more about the light-producing reaction and enable the design of future superior bioluminescent systems with applications in biomedicine, biotechnology, as biosensors or even to provide an environmentally friendly alternative for electricity-generated light.
LinkedIn: linkedin.com/in/jana-horáčková-387790137
ResearchGate: https://www.researchgate.net/profile/Jana-Horackova