EXPERIMENT_ID SEQUENCE_ID MUTANT_ID SOURCE_SEQUENCE_ID TARGET_SEQUENCE_ID SEQUENCE_LENGTH SUBSTITUTION INSERTION DELETION PROTEIN ORGANISM CHYMOTRYPSIN_ML CM DCP DDG DG DH DHVH DOMAINOME_DDG DOMAINOME_DDG_STD DOMAINOME_FITNESS DOMAINOME_FITNESS_STD DTM M REVERSIBILITY STABILIZING STATE TM TRYPSIN_ML BUFFER BUFFER_CONC EXP_TEMPERATURE ION ION_CONC MEASURE METHOD PH EC_NUMBER UNIPROTKB INTERPRO MEGASCALE ACTIVE_SITE BINDING_SITE CONSERVATION WWPDB B_FACTOR IN_TUNNEL IN_POCKET PUBLICATION_PMID PUBLICATION_DOI PUBLICATION_YEAR SOURCE_DATASET REFERENCING_DATASET 17395 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) yes 59.5 Sodium phosphate 1 mM DSC Thermal 7.2 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 1727648 10.1016/0003-9861(92)90047-z 1992 ProTherm 17396 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.11 119.5 yes 54.3 Sodium tetraborate 1mM DSC Thermal 8.7 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8263921 10.1006/jmbi.1993.1670 1993 ProTherm 17725 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.09 3.15 Unknown 54.2 sodium tetraborate 1 mM DSC Thermal 8.98 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA DOI: 10.1016/0040-6031(90)80386-D ProTherm 17943 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.45 19.7 yes(70-95%) 61.2 tetra-borate 1 mM CD Thermal 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 6384087 1984 ProTherm 17944 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.45 19.7 yes(70-95%) 50.4 tetra-borate 1 mM CD Thermal 9.3 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 6384087 1984 ProTherm 17945 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.87 yes(70-95%) 62.4 tetra-borate 1 mM DSC Thermal 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 6384087 1984 ProTherm 17946 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.87 yes(70-95%) 54.3 tetra-borate 1 mM DSC Thermal 9.3 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 6384087 1984 ProTherm 18002 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.9 yes(<50%) 62.4 potassium phosphate 1 mM DSC Thermal 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 6816746 10.1111/j.1399-3011.1982.tb00898.x 1982 ProTherm 18003 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.9 yes(>70%) 54.3 sodium tetraborate 1 mM DSC Thermal 9.3 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 6816746 10.1111/j.1399-3011.1982.tb00898.x 1982 ProTherm 18005 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.81 94.26 yes 53.7 Sodium tetraborate 1 mM DSC Thermal 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8795042 10.1093/protein/9.5.425 1996 ProTherm 19566 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) yes(>70%) 54.0 Sodium tetraborate 1 mM DSC Thermal 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8797836 10.1111/j.1432-1033.1996.0063h.x 1996 ProTherm 19925 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.1 93.8 109.0 yes 57.8 Sodium phosphate 1 mM DSC Thermal 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 6992862 10.1021/bi00548a004 1980 ProTherm 19927 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.6 120.4 yes 54.1 Sodium tetraborate 1 mM DSC Thermal 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 2008436 10.1002/prot.340090203 1991 ProTherm 20154 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.81 1.17 yes Sodium tetraborate 1 mM 50.0 DSC Thermal 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8795042 10.1093/protein/9.5.425 1996 ProTherm 20403 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 8.8 yes Potassium phosphate 0.01 M 25.8 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 378988 10.1093/oxfordjournals.jbchem.a132423 1979 ProTherm 20408 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.9 yes Tris-HCl 0.025 M 25.0 CD GdnHCl 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 6757449 10.1016/0022-2836(82)90184-x 1982 ProTherm 20409 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 8.8 yes Potassium phosphate 0.01 M 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 6757449 10.1016/0022-2836(82)90184-x 1982 ProTherm 20410 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 5.2 yes acetate 0.05 M 25.0 CD GdnHCl 5.5 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 6757449 10.1016/0022-2836(82)90184-x 1982 ProTherm 20512 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 6.7 yes(70-95%) tetra-borate 1 mM 25.0 CD Thermal 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 6384087 1984 ProTherm 20513 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.9 yes(70-95%) tetra-borate 1 mM 25.0 CD Thermal 9.3 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 6384087 1984 ProTherm 20514 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 8.4 23.2 yes(70-95%) tetra-borate 1 mM 25.0 DSC Thermal 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 6384087 1984 ProTherm 20515 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 5.8 23.2 yes(70-95%) tetra-borate 1 mM 25.0 DSC Thermal 9.3 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 6384087 1984 ProTherm 20522 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.9 8.4 yes(<50%) potassium phosphate 1 mM 25.0 DSC Thermal 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 6816746 10.1111/j.1399-3011.1982.tb00898.x 1982 ProTherm 20523 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.9 5.8 yes(>70%) sodium tetraborate 1 mM 25.0 DSC Thermal 9.3 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 6816746 10.1111/j.1399-3011.1982.tb00898.x 1982 ProTherm 20593 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.6 yes 3.0 Potassium phosphate 10 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 2008436 10.1002/prot.340090203 1991 ProTherm 20594 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.2 yes 3.0 Potassium phosphate 10 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 2008436 10.1002/prot.340090203 1991 ProTherm 20626 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 5.91 2.23 Unknown Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9893998 10.1021/bi982365q 1999 ProTherm 20627 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 7.9 2.9 Unknown 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9893998 10.1021/bi982365q 1999 ProTherm 20628 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 5.4 1.3 Unknown 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9893998 10.1021/bi982365q 1999 ProTherm 20670 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 8.21 yes Tris-HCl 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9020793 10.1021/bi961660c 1997 ProTherm 20695 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.73 4.16 1.12 Unknown 2.0 Potassium phosphate 10 mM 25.0 Absorbance Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 10433729 10.1021/bi9909041 1999 ProTherm 20696 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.67 4.08 1.11 Unknown 2.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 10433729 10.1021/bi9909041 1999 ProTherm 20697 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.72 3.97 1.07 Unknown 2.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 10433729 10.1021/bi9909041 1999 ProTherm 20698 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.65 3.96 1.09 Unknown 2.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 10433729 10.1021/bi9909041 1999 ProTherm 20699 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.94 4.31 1.09 Unknown 2.0 Potassium phosphate 10 mM 25.0 Fluorescence Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 10433729 10.1021/bi9909041 1999 ProTherm 20700 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.81 4.14 1.09 Unknown 2.0 Potassium phosphate 10 mM 25.0 Fluorescence Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 10433729 10.1021/bi9909041 1999 ProTherm 20707 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.62 5.7 2.2 yes (>90%) 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 2872918 10.1021/bi00358a035 1986 ProTherm 20708 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.18 5.0 1.2 yes (>90%) 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 2872918 10.1021/bi00358a035 1986 ProTherm 20737 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.62 5.7 2.2 Unknown Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 2185841 10.1021/bi00458a027 1990 ProTherm 20738 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.18 5.0 1.2 Unknown Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 2185841 10.1021/bi00458a027 1990 ProTherm 20753 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.62 2.2 Unknown 3.0 Potassium phosphate 10 mM 25.0 Absorbance Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 3539187 10.1021/bi00369a002 1986 ProTherm 20754 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.18 1.2 Unknown 3.0 Potassium phosphate 10 mM 25.0 Absorbance Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 3539187 10.1021/bi00369a002 1986 ProTherm 20813 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.62 5.7 2.18 yes (>90%) 3.0 Potassium phosphate 10 mM 25.0 Absorbance Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 3280027 10.1021/bi00402a050 1988 ProTherm 20814 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.18 5.0 1.2 yes (>90%) 3.0 Potassium phosphate 10 mM 25.0 Absorbance Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 3280027 10.1021/bi00402a050 1988 ProTherm 20815 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.76 6.1 2.19 yes (>90%) 3.0 Potassium phosphate 10 mM 25.0 Absorbance Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 3280027 10.1021/bi00402a050 1988 ProTherm 20816 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.93 6.2 1.56 yes (>90%) 3.0 Potassium phosphate 10 mM 25.0 Absorbance Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 3280027 10.1021/bi00402a050 1988 ProTherm 20817 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 1.98 5.4 2.73 yes (>90%) 3.0 Potassium phosphate 10 mM 25.0 Absorbance Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 3280027 10.1021/bi00402a050 1988 ProTherm 20818 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.4 4.8 1.4 yes (>90%) 3.0 Potassium phosphate 10 mM 25.0 Absorbance Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 3280027 10.1021/bi00402a050 1988 ProTherm 20819 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.17 5.4 2.49 yes (>90%) 3.0 Potassium phosphate 10 mM 25.0 Absorbance Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 3280027 10.1021/bi00402a050 1988 ProTherm 20820 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.37 6.2 1.84 yes (>90%) 3.0 Potassium phosphate 10 mM 25.0 Absorbance Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 3280027 10.1021/bi00402a050 1988 ProTherm 20821 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 1.95 6.4 3.28 yes (>90%) 3.0 Potassium phosphate 10 mM 25.0 Absorbance Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 3280027 10.1021/bi00402a050 1988 ProTherm 20822 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.01 4.0 1.34 yes (>90%) 3.0 Potassium phosphate 10 mM 25.0 Absorbance Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 3280027 10.1021/bi00402a050 1988 ProTherm 20823 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.01 5.0 2.5 yes (>90%) 3.0 Potassium phosphate 10 mM 25.0 Absorbance Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 3280027 10.1021/bi00402a050 1988 ProTherm 20824 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.54 6.3 1.78 yes (>90%) 3.0 Potassium phosphate 10 mM 25.0 Absorbance Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 3280027 10.1021/bi00402a050 1988 ProTherm 20825 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 1.92 3.9 2.02 yes (>90%) 3.0 Potassium phosphate 10 mM 25.0 Absorbance Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 3280027 10.1021/bi00402a050 1988 ProTherm 20826 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.33 3.7 1.1 yes (>90%) 3.0 Potassium phosphate 10 mM 25.0 Absorbance Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 3280027 10.1021/bi00402a050 1988 ProTherm 20851 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.5 6.8 2.8 Unknown 3.0 phosphate 58 mM 25.0 Absorbance Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8268176 10.1021/bi00213a031 1993 ProTherm 20852 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.9 5.1 1.3 Unknown 3.0 phosphate 58 mM 25.0 Absorbance Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8268176 10.1021/bi00213a031 1993 ProTherm 20853 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.5 6.2 2.5 Unknown 3.0 phosphate 58 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8268176 10.1021/bi00213a031 1993 ProTherm 20854 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.0 4.6 1.2 Unknown 3.0 phosphate 58 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8268176 10.1021/bi00213a031 1993 ProTherm 20878 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 5.9 8.2 yes Potassium phosphate 58 mM 25.0 NMR Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8639683 10.1021/bi951726o 1996 ProTherm 20988 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 6.0 2.2 Unknown 4.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 10529212 10.1021/bi991296s 1999 ProTherm 20989 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 5.7 2.0 Unknown 4.0 Potassium phosphate 100 mM 25.0 SEC Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 10529212 10.1021/bi991296s 1999 ProTherm 20990 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 5.3 2.0 Unknown 4.0 Potassium phosphate 10 mM 25.0 SAXS Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 10529212 10.1021/bi991296s 1999 ProTherm 20991 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.5 1.1 Unknown 4.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 10529212 10.1021/bi991296s 1999 ProTherm 20992 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.9 1.2 Unknown 4.0 Potassium phosphate 100 mM 25.0 SEC Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 10529212 10.1021/bi991296s 1999 ProTherm 20993 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.1 0.9 Unknown 4.0 Potassium phosphate 10 mM 25.0 SAXS Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 10529212 10.1021/bi991296s 1999 ProTherm 20994 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.9 0.84 Unknown 4.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 10529212 10.1021/bi991296s 1999 ProTherm 20995 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 5.0 0.85 Unknown 4.0 Potassium phosphate 10 mM 25.0 SAXS Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 10529212 10.1021/bi991296s 1999 ProTherm 21084 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.71 3.71 1.0 yes(>90%) Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 10386870 10.1110/ps.8.6.1200 1999 ProTherm 21085 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.72 3.6 0.97 yes(>90%) Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 10386870 10.1110/ps.8.6.1200 1999 ProTherm 21086 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.73 4.05 1.09 yes(>90%) Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 10386870 10.1110/ps.8.6.1200 1999 ProTherm 21087 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.87 2.48 0.87 yes(>90%) Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 10386870 10.1110/ps.8.6.1200 1999 ProTherm 21088 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.8 2.41 0.86 yes(>90%) Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 10386870 10.1110/ps.8.6.1200 1999 ProTherm 21089 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.7 2.31 0.85 yes(>90%) Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 10386870 10.1110/ps.8.6.1200 1999 ProTherm 21090 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.62 5.27 2.01 yes(>90%) Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 10386870 10.1110/ps.8.6.1200 1999 ProTherm 21091 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.93 4.8 1.22 yes(>90%) Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 10386870 10.1110/ps.8.6.1200 1999 ProTherm 21092 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 5.9 7.7 1.3 yes(>90%) Potassium phosphate 58 mM 25.0 NMR Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 10386870 10.1110/ps.8.6.1200 1999 ProTherm 21093 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 6.1 4.3 0.7 yes(>90%) Potassium phosphate 58 mM 25.0 NMR Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 10386870 10.1110/ps.8.6.1200 1999 ProTherm 21094 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 5.2 4.8 0.9 yes(>90%) Potassium phosphate 58 mM 25.0 NMR Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 10386870 10.1110/ps.8.6.1200 1999 ProTherm 21095 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 5.1 4.2 0.8 yes(>90%) Potassium phosphate 58 mM 25.0 NMR Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 10386870 10.1110/ps.8.6.1200 1999 ProTherm 21096 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 5.4 4.2 0.8 yes(>90%) Potassium phosphate 58 mM 25.0 NMR Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 10386870 10.1110/ps.8.6.1200 1999 ProTherm 21097 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 5.5 3.5 0.6 yes(>90%) Potassium phosphate 58 mM 25.0 NMR Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 10386870 10.1110/ps.8.6.1200 1999 ProTherm 21098 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.5 2.1 0.5 yes(>90%) Potassium phosphate 58 mM 25.0 NMR Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 10386870 10.1110/ps.8.6.1200 1999 ProTherm 21099 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 6.0 2.2 Unknown 3.0 Potassium phosphate 100 mM 25.0 Fluorescence Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 10452606 10.1110/ps.8.8.1623 1999 ProTherm 21100 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 6.6 2.4 Unknown 3.0 Potassium phosphate 100 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 10452606 10.1110/ps.8.8.1623 1999 ProTherm 21101 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.5 1.1 Unknown 3.0 Potassium phosphate 100 mM 25.0 Fluorescence Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 10452606 10.1110/ps.8.8.1623 1999 ProTherm 21102 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.6 1.1 Unknown 3.0 Potassium phosphate 100 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 10452606 10.1110/ps.8.8.1623 1999 ProTherm 21103 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.9 0.83 Unknown 3.0 Potassium phosphate 100 mM 25.0 Fluorescence Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 10452606 10.1110/ps.8.8.1623 1999 ProTherm 21104 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.4 0.69 Unknown 3.0 Potassium phosphate 100 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 10452606 10.1110/ps.8.8.1623 1999 ProTherm 21250 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 9.3 yes Potassium phosphate 0.01 M 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 6367660 10.1016/0003-9861(84)90174-7 1984 ProTherm 21367 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 18.16 yes Potassium phosphate 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 3299367 10.1073/pnas.84.13.4441 1987 ProTherm 21368 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 17.97 yes Potassium phosphate 20 mM 25.0 CD GdnHCl 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 3299367 10.1073/pnas.84.13.4441 1987 ProTherm 21381 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 8.8 yes Potassium phosphate 10 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 2008436 10.1002/prot.340090203 1991 ProTherm 21404 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.23 yes 3.0 Tris-HCl 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9020793 10.1021/bi961660c 1997 ProTherm 21405 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.0 yes 3.0 Tris-HCl 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9020793 10.1021/bi961660c 1997 ProTherm 21512 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.51 6.4 2.5 yes 3.0 Potassium phosphate 10 mM 23.0 Absorbance Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 7629069 10.1074/jbc.270.30.17712 1995 ProTherm 21513 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.73 5.2 1.4 yes 3.0 Potassium phosphate 10 mM 23.0 Absorbance Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 7629069 10.1074/jbc.270.30.17712 1995 ProTherm 21724 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 5.4 7.5 yes Potassium phosphate 58 mM 20.0 NMR Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8639683 10.1021/bi951726o 1996 ProTherm 21930 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.7 6.1 yes Potassium phosphate 58 mM 15.0 NMR Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8639683 10.1021/bi951726o 1996 ProTherm 21981 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.6 5.5 yes Potassium phosphate 58 mM 10.0 NMR Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8639683 10.1021/bi951726o 1996 ProTherm 22020 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.8 4.8 yes Potassium phosphate 58 mM 5.0 NMR Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8639683 10.1021/bi951726o 1996 ProTherm 22049 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 1.63 5.0 3.1 Unknown Potassium phosphate 10 mM 4.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 2185841 10.1021/bi00458a027 1990 ProTherm 22050 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.17 6.0 1.9 Unknown Potassium phosphate 10 mM 4.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 2185841 10.1021/bi00458a027 1990 ProTherm 26001 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.68 6.13 2.29 Unknown 3.0 potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 12215410 10.1016/s0022-2836(02)00737-4 2002 ProTherm 26002 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.93 4.72 1.2 Unknown 3.0 potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 12215410 10.1016/s0022-2836(02)00737-4 2002 ProTherm 26098 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 6.13 2.29 Unknown 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 16023136 10.1016/j.jmb.2005.06.006 2005 ProTherm 26099 1 268 Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.72 1.2 Unknown 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 16023136 10.1016/j.jmb.2005.06.006 2005 ProTherm 28 28 268 S6P Tryptophan synthase alpha chain Escherichia coli (strain K12) -5.2 yes 54.3 Sodium phosphate 1 mM DSC Thermal 7.2 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 2.0 1WQ5 22.049999872843426 in pocket 1727648 10.1016/0003-9861(92)90047-z 1992 ProTherm 24 24 268 P21S Tryptophan synthase alpha chain Escherichia coli (strain K12) -4.3 yes 55.2 Sodium phosphate 1 mM DSC Thermal 7.2 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 5.0 1WQ5 16.06000014713832 1727648 10.1016/0003-9861(92)90047-z 1992 ProTherm 10 10 268 F22S Tryptophan synthase alpha chain Escherichia coli (strain K12) 0.8 yes 60.3 Sodium phosphate 1 mM DSC Thermal 7.2 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8.0 1WQ5 20.991818341341887 in tunnel in pocket 1727648 10.1016/0003-9861(92)90047-z 1992 ProTherm HotMuSiC_S1626.csv 10455 4407 268 F22L Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.54 -2.2 7.9 3.1 yes (>90%) 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8.0 1WQ5 20.991818341341887 in tunnel in pocket 2872918 10.1021/bi00358a035 1986 ProTherm 10456 4407 268 F22L Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.62 0.8 4.2 1.2 yes (>90%) 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8.0 1WQ5 20.991818341341887 in tunnel in pocket 2872918 10.1021/bi00358a035 1986 ProTherm 6 6 268 T24M Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.3 yes 61.8 Sodium phosphate 1 mM DSC Thermal 7.2 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8.0 1WQ5 24.547143118722097 in pocket 1727648 10.1016/0003-9861(92)90047-z 1992 ProTherm HotMuSiC_S1626.csv 1 1 268 P28S Tryptophan synthase alpha chain Escherichia coli (strain K12) -6.4 yes 53.1 Sodium phosphate 1 mM DSC Thermal 7.2 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 33.39428574698312 1727648 10.1016/0003-9861(92)90047-z 1992 ProTherm HotMuSiC_S1626.csv 26 26 268 P28L Tryptophan synthase alpha chain Escherichia coli (strain K12) -4.6 yes 54.9 Sodium phosphate 1 mM DSC Thermal 7.2 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 33.39428574698312 1727648 10.1016/0003-9861(92)90047-z 1992 ProTherm 8860 3847 268 P28G Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.3 2.3 yes 3.0 Potassium phosphate 10 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 33.39428574698312 2008436 10.1002/prot.340090203 1991 ProTherm 8861 3847 268 P28G Tryptophan synthase alpha chain Escherichia coli (strain K12) -0.7 4.9 yes 3.0 Potassium phosphate 10 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 33.39428574698312 2008436 10.1002/prot.340090203 1991 ProTherm 9282 3847 268 P28G Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.08 1.66 4.47 2.15 Unknown 3.0 potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 33.39428574698312 12215410 10.1016/s0022-2836(02)00737-4 2002 ProTherm 9284 3847 268 P28G Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.1 -0.12 4.84 1.18 Unknown 3.0 potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 33.39428574698312 12215410 10.1016/s0022-2836(02)00737-4 2002 ProTherm 11352 3847 268 P28G Tryptophan synthase alpha chain Escherichia coli (strain K12) 1.6 7.2 yes Potassium phosphate 10 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 33.39428574698312 2008436 10.1002/prot.340090203 1991 ProTherm 8862 3848 268 P28A Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.4 2.2 yes 3.0 Potassium phosphate 10 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 33.39428574698312 2008436 10.1002/prot.340090203 1991 ProTherm 8863 3848 268 P28A Tryptophan synthase alpha chain Escherichia coli (strain K12) 0.1 4.1 yes 3.0 Potassium phosphate 10 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 33.39428574698312 2008436 10.1002/prot.340090203 1991 ProTherm 9281 3848 268 P28A Tryptophan synthase alpha chain Escherichia coli (strain K12) 1.36 4.12 2.01 1.48 Unknown 3.0 potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 33.39428574698312 12215410 10.1016/s0022-2836(02)00737-4 2002 ProTherm 9283 3848 268 P28A Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.66 0.91 3.81 1.04 Unknown 3.0 potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 33.39428574698312 12215410 10.1016/s0022-2836(02)00737-4 2002 ProTherm 10038 3848 268 P28A Tryptophan synthase alpha chain Escherichia coli (strain K12) 1.91 6.29 yes Tris-HCl 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 33.39428574698312 9020793 10.1021/bi961660c 1997 ProTherm 11353 3848 268 P28A Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.5 6.3 yes Potassium phosphate 10 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 33.39428574698312 2008436 10.1002/prot.340090203 1991 ProTherm 11370 3848 268 P28A Tryptophan synthase alpha chain Escherichia coli (strain K12) 1.96 2.27 yes 3.0 Tris-HCl 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 33.39428574698312 9020793 10.1021/bi961660c 1997 ProTherm 11371 3848 268 P28A Tryptophan synthase alpha chain Escherichia coli (strain K12) -0.05 4.04 yes 3.0 Tris-HCl 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 33.39428574698312 9020793 10.1021/bi961660c 1997 ProTherm 2 2 268 S33L Tryptophan synthase alpha chain Escherichia coli (strain K12) -7.6 yes 51.9 Sodium phosphate 1 mM DSC Thermal 7.2 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8.0 1WQ5 21.75333309173584 1727648 10.1016/0003-9861(92)90047-z 1992 ProTherm HotMuSiC_S1626.csv 9650 4219 268 I37A Tryptophan synthase alpha chain Escherichia coli (strain K12) 1.41 4.72 2.72 Unknown 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 6.0 1WQ5 21.605000019073486 16023136 10.1016/j.jmb.2005.06.006 2005 ProTherm 9655 4219 268 I37A Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.01 1.71 0.64 Unknown 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 6.0 1WQ5 21.605000019073486 16023136 10.1016/j.jmb.2005.06.006 2005 ProTherm 14 14 268 E49G Tryptophan synthase alpha chain Escherichia coli (strain K12) -1.8 yes 57.7 Sodium phosphate 1 mM DSC Thermal 7.2 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 1727648 10.1016/0003-9861(92)90047-z 1992 ProTherm 11285 14 268 E49G Tryptophan synthase alpha chain Escherichia coli (strain K12) -0.08 18.24 yes Potassium phosphate 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 3299367 10.1073/pnas.84.13.4441 1987 ProTherm khan_protherm_data_mapped.csv 11303 14 268 E49G Tryptophan synthase alpha chain Escherichia coli (strain K12) -0.6 18.57 yes Potassium phosphate 20 mM 25.0 CD GdnHCl 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 3299367 10.1073/pnas.84.13.4441 1987 ProTherm 328 187 268 E49Q Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.68 14.3 yes(70-95%) 59.6 tetra-borate 1 mM CD Thermal 7.2 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 6384087 1984 ProTherm 329 187 268 E49Q Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.68 14.3 yes(70-95%) 59.6 tetra-borate 1 mM CD Thermal 9.3 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 6384087 1984 ProTherm 330 187 268 E49Q Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.87 yes(70-95%) 59.4 tetra-borate 1 mM DSC Thermal 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 6384087 1984 ProTherm 331 187 268 E49Q Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.87 yes(70-95%) 62.4 tetra-borate 1 mM DSC Thermal 9.3 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 6384087 1984 ProTherm HotMuSiC_S1626.csv 458 187 268 E49Q Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.9 yes(<50%) 59.4 potassium phosphate 1 mM DSC Thermal 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 6816746 10.1111/j.1399-3011.1982.tb00898.x 1982 ProTherm 460 187 268 E49Q Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.9 yes(>70%) 62.4 sodium tetraborate 1 mM DSC Thermal 9.3 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 6816746 10.1111/j.1399-3011.1982.tb00898.x 1982 ProTherm 8476 187 268 E49Q Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.5 6.3 yes Potassium phosphate 0.01 M 25.8 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 378988 10.1093/oxfordjournals.jbchem.a132423 1979 ProTherm 8533 187 268 E49Q Tryptophan synthase alpha chain Escherichia coli (strain K12) -3.6 8.5 yes Tris-HCl 0.025 M 25.0 CD GdnHCl 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 6757449 10.1016/0022-2836(82)90184-x 1982 ProTherm 8538 187 268 E49Q Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.5 6.3 yes Potassium phosphate 0.01 M 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 6757449 10.1016/0022-2836(82)90184-x 1982 ProTherm 8543 187 268 E49Q Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.4 2.8 yes acetate 0.05 M 25.0 CD GdnHCl 5.5 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 6757449 10.1016/0022-2836(82)90184-x 1982 ProTherm 8686 187 268 E49Q Tryptophan synthase alpha chain Escherichia coli (strain K12) 6.1 yes(70-95%) tetra-borate 1 mM 25.0 CD Thermal 7.2 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 6384087 1984 ProTherm 8687 187 268 E49Q Tryptophan synthase alpha chain Escherichia coli (strain K12) 6.1 yes(70-95%) tetra-borate 1 mM 25.0 CD Thermal 9.3 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 6384087 1984 ProTherm 8688 187 268 E49Q Tryptophan synthase alpha chain Escherichia coli (strain K12) 7.4 23.2 yes(70-95%) tetra-borate 1 mM 25.0 DSC Thermal 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 6384087 1984 ProTherm 8689 187 268 E49Q Tryptophan synthase alpha chain Escherichia coli (strain K12) 8.4 23.2 yes(70-95%) tetra-borate 1 mM 25.0 DSC Thermal 9.3 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 6384087 1984 ProTherm 8753 187 268 E49Q Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.9 7.4 yes(<50%) potassium phosphate 1 mM 25.0 DSC Thermal 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 6816746 10.1111/j.1399-3011.1982.tb00898.x 1982 ProTherm 8755 187 268 E49Q Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.9 8.4 yes(>70%) sodium tetraborate 1 mM 25.0 DSC Thermal 9.3 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 6816746 10.1111/j.1399-3011.1982.tb00898.x 1982 ProTherm 11297 187 268 E49Q Tryptophan synthase alpha chain Escherichia coli (strain K12) 0.23 17.93 yes Potassium phosphate 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 3299367 10.1073/pnas.84.13.4441 1987 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 11315 187 268 E49Q Tryptophan synthase alpha chain Escherichia coli (strain K12) -0.54 18.51 yes Potassium phosphate 20 mM 25.0 CD GdnHCl 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 3299367 10.1073/pnas.84.13.4441 1987 ProTherm 459 255 268 E49S Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.9 yes(<50%) 60.5 potassium phosphate 1 mM DSC Thermal 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 6816746 10.1111/j.1399-3011.1982.tb00898.x 1982 ProTherm 461 255 268 E49S Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.9 yes(>70%) 58.6 sodium tetraborate 1 mM DSC Thermal 9.3 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 6816746 10.1111/j.1399-3011.1982.tb00898.x 1982 ProTherm 8534 255 268 E49S Tryptophan synthase alpha chain Escherichia coli (strain K12) -3.1 8.0 yes Tris-HCl 0.025 M 25.0 CD GdnHCl 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 6757449 10.1016/0022-2836(82)90184-x 1982 ProTherm 8539 255 268 E49S Tryptophan synthase alpha chain Escherichia coli (strain K12) 1.4 7.4 yes Potassium phosphate 0.01 M 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 6757449 10.1016/0022-2836(82)90184-x 1982 ProTherm 8544 255 268 E49S Tryptophan synthase alpha chain Escherichia coli (strain K12) 1.3 3.9 yes acetate 0.05 M 25.0 CD GdnHCl 5.5 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 6757449 10.1016/0022-2836(82)90184-x 1982 ProTherm 8754 255 268 E49S Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.9 7.7 yes(<50%) potassium phosphate 1 mM 25.0 DSC Thermal 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 6816746 10.1111/j.1399-3011.1982.tb00898.x 1982 ProTherm 8756 255 268 E49S Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.9 7.1 yes(>70%) sodium tetraborate 1 mM 25.0 DSC Thermal 9.3 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 6816746 10.1111/j.1399-3011.1982.tb00898.x 1982 ProTherm 11302 255 268 E49S Tryptophan synthase alpha chain Escherichia coli (strain K12) 0.59 17.57 yes Potassium phosphate 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 3299367 10.1073/pnas.84.13.4441 1987 ProTherm 11320 255 268 E49S Tryptophan synthase alpha chain Escherichia coli (strain K12) -0.09 18.06 yes Potassium phosphate 20 mM 25.0 CD GdnHCl 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 3299367 10.1073/pnas.84.13.4441 1987 ProTherm khan_protherm_data_mapped.csv 8477 3691 268 E49M Tryptophan synthase alpha chain Escherichia coli (strain K12) -4.6 13.4 yes Potassium phosphate 0.01 M 25.8 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 378988 10.1093/oxfordjournals.jbchem.a132423 1979 ProTherm 8535 3691 268 E49M Tryptophan synthase alpha chain Escherichia coli (strain K12) -3.5 8.4 yes Tris-HCl 0.025 M 25.0 CD GdnHCl 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 6757449 10.1016/0022-2836(82)90184-x 1982 ProTherm 8540 3691 268 E49M Tryptophan synthase alpha chain Escherichia coli (strain K12) -4.5 13.3 yes Potassium phosphate 0.01 M 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 6757449 10.1016/0022-2836(82)90184-x 1982 ProTherm 8545 3691 268 E49M Tryptophan synthase alpha chain Escherichia coli (strain K12) -0.7 5.9 yes acetate 0.05 M 25.0 CD GdnHCl 5.5 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 6757449 10.1016/0022-2836(82)90184-x 1982 ProTherm 10457 3691 268 E49M Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.33 -3.7 9.4 2.8 yes (>90%) 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 2872918 10.1021/bi00358a035 1986 ProTherm 10458 3691 268 E49M Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.92 -2.0 7.0 1.4 yes (>90%) 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 2872918 10.1021/bi00358a035 1986 ProTherm 11300 3691 268 E49M Tryptophan synthase alpha chain Escherichia coli (strain K12) 0.05 18.11 yes Potassium phosphate 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 3299367 10.1073/pnas.84.13.4441 1987 ProTherm khan_protherm_data_mapped.csv 11318 3691 268 E49M Tryptophan synthase alpha chain Escherichia coli (strain K12) -0.52 18.49 yes Potassium phosphate 20 mM 25.0 CD GdnHCl 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 3299367 10.1073/pnas.84.13.4441 1987 ProTherm 8536 3722 268 E49V Tryptophan synthase alpha chain Escherichia coli (strain K12) -4.5 9.4 yes Tris-HCl 0.025 M 25.0 CD GdnHCl 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 6757449 10.1016/0022-2836(82)90184-x 1982 ProTherm 8541 3722 268 E49V Tryptophan synthase alpha chain Escherichia coli (strain K12) -3.2 12.0 yes Potassium phosphate 0.01 M 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 6757449 10.1016/0022-2836(82)90184-x 1982 ProTherm 8546 3722 268 E49V Tryptophan synthase alpha chain Escherichia coli (strain K12) -0.9 6.1 yes acetate 0.05 M 25.0 CD GdnHCl 5.5 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 6757449 10.1016/0022-2836(82)90184-x 1982 ProTherm 11287 3722 268 E49V Tryptophan synthase alpha chain Escherichia coli (strain K12) -0.14 18.3 yes Potassium phosphate 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 3299367 10.1073/pnas.84.13.4441 1987 ProTherm khan_protherm_data_mapped.csv 11305 3722 268 E49V Tryptophan synthase alpha chain Escherichia coli (strain K12) -1.01 18.98 yes Potassium phosphate 20 mM 25.0 CD GdnHCl 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 3299367 10.1073/pnas.84.13.4441 1987 ProTherm 8537 3723 268 E49Y Tryptophan synthase alpha chain Escherichia coli (strain K12) -1.9 6.8 yes Tris-HCl 0.025 M 25.0 CD GdnHCl 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 6757449 10.1016/0022-2836(82)90184-x 1982 ProTherm 8542 3723 268 E49Y Tryptophan synthase alpha chain Escherichia coli (strain K12) 0.0 8.8 yes Potassium phosphate 0.01 M 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 6757449 10.1016/0022-2836(82)90184-x 1982 ProTherm potapov_with_uniprot_mapping.csv 8547 3723 268 E49Y Tryptophan synthase alpha chain Escherichia coli (strain K12) 0.4 4.8 yes acetate 0.05 M 25.0 CD GdnHCl 5.5 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 6757449 10.1016/0022-2836(82)90184-x 1982 ProTherm 11291 3723 268 E49Y Tryptophan synthase alpha chain Escherichia coli (strain K12) 0.17 17.99 yes Potassium phosphate 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 3299367 10.1073/pnas.84.13.4441 1987 ProTherm khan_protherm_data_mapped.csv 11309 3723 268 E49Y Tryptophan synthase alpha chain Escherichia coli (strain K12) -0.26 18.23 yes Potassium phosphate 20 mM 25.0 CD GdnHCl 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 3299367 10.1073/pnas.84.13.4441 1987 ProTherm 11286 4804 268 E49A Tryptophan synthase alpha chain Escherichia coli (strain K12) 0.08 18.08 yes Potassium phosphate 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 3299367 10.1073/pnas.84.13.4441 1987 ProTherm khan_protherm_data_mapped.csv 11304 4804 268 E49A Tryptophan synthase alpha chain Escherichia coli (strain K12) -0.59 18.56 yes Potassium phosphate 20 mM 25.0 CD GdnHCl 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 3299367 10.1073/pnas.84.13.4441 1987 ProTherm 11288 4805 268 E49I Tryptophan synthase alpha chain Escherichia coli (strain K12) -0.46 18.62 yes Potassium phosphate 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 3299367 10.1073/pnas.84.13.4441 1987 ProTherm khan_protherm_data_mapped.csv 11306 4805 268 E49I Tryptophan synthase alpha chain Escherichia coli (strain K12) -1.24 19.21 yes Potassium phosphate 20 mM 25.0 CD GdnHCl 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 3299367 10.1073/pnas.84.13.4441 1987 ProTherm 11289 4806 268 E49L Tryptophan synthase alpha chain Escherichia coli (strain K12) -0.44 18.6 yes Potassium phosphate 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 3299367 10.1073/pnas.84.13.4441 1987 ProTherm khan_protherm_data_mapped.csv 11307 4806 268 E49L Tryptophan synthase alpha chain Escherichia coli (strain K12) -1.04 19.01 yes Potassium phosphate 20 mM 25.0 CD GdnHCl 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 3299367 10.1073/pnas.84.13.4441 1987 ProTherm 11290 4807 268 E49P Tryptophan synthase alpha chain Escherichia coli (strain K12) 0.0 18.16 yes Potassium phosphate 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 3299367 10.1073/pnas.84.13.4441 1987 ProTherm khan_protherm_data_mapped.csv 11308 4807 268 E49P Tryptophan synthase alpha chain Escherichia coli (strain K12) -0.8 18.77 yes Potassium phosphate 20 mM 25.0 CD GdnHCl 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 3299367 10.1073/pnas.84.13.4441 1987 ProTherm khan_protherm_data_mapped.csv 11292 4808 268 E49F Tryptophan synthase alpha chain Escherichia coli (strain K12) 0.86 17.3 yes Potassium phosphate 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 3299367 10.1073/pnas.84.13.4441 1987 ProTherm 11310 4808 268 E49F Tryptophan synthase alpha chain Escherichia coli (strain K12) 0.02 17.95 yes Potassium phosphate 20 mM 25.0 CD GdnHCl 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 3299367 10.1073/pnas.84.13.4441 1987 ProTherm khan_protherm_data_mapped.csv 11293 4809 268 E49W Tryptophan synthase alpha chain Escherichia coli (strain K12) 0.97 17.19 yes Potassium phosphate 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 3299367 10.1073/pnas.84.13.4441 1987 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 11311 4809 268 E49W Tryptophan synthase alpha chain Escherichia coli (strain K12) 1.1 16.87 yes Potassium phosphate 20 mM 25.0 CD GdnHCl 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 3299367 10.1073/pnas.84.13.4441 1987 ProTherm potapov_with_uniprot_mapping.csv 11294 4810 268 E49H Tryptophan synthase alpha chain Escherichia coli (strain K12) -0.33 18.49 yes Potassium phosphate 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 3299367 10.1073/pnas.84.13.4441 1987 ProTherm khan_protherm_data_mapped.csv 11312 4810 268 E49H Tryptophan synthase alpha chain Escherichia coli (strain K12) -0.67 18.64 yes Potassium phosphate 20 mM 25.0 CD GdnHCl 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 3299367 10.1073/pnas.84.13.4441 1987 ProTherm 11295 4811 268 E49K Tryptophan synthase alpha chain Escherichia coli (strain K12) -0.2 17.96 yes Potassium phosphate 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 3299367 10.1073/pnas.84.13.4441 1987 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 11313 4811 268 E49K Tryptophan synthase alpha chain Escherichia coli (strain K12) -0.39 18.36 yes Potassium phosphate 20 mM 25.0 CD GdnHCl 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 3299367 10.1073/pnas.84.13.4441 1987 ProTherm potapov_with_uniprot_mapping.csv 11296 4812 268 E49N Tryptophan synthase alpha chain Escherichia coli (strain K12) 0.69 17.47 yes Potassium phosphate 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 3299367 10.1073/pnas.84.13.4441 1987 ProTherm 11314 4812 268 E49N Tryptophan synthase alpha chain Escherichia coli (strain K12) -0.27 18.24 yes Potassium phosphate 20 mM 25.0 CD GdnHCl 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 3299367 10.1073/pnas.84.13.4441 1987 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 11298 4813 268 E49D Tryptophan synthase alpha chain Escherichia coli (strain K12) 0.8 17.36 yes Potassium phosphate 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 3299367 10.1073/pnas.84.13.4441 1987 ProTherm SAAFEC_S1262.csv 11316 4813 268 E49D Tryptophan synthase alpha chain Escherichia coli (strain K12) 0.03 17.94 yes Potassium phosphate 20 mM 25.0 CD GdnHCl 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 3299367 10.1073/pnas.84.13.4441 1987 ProTherm khan_protherm_data_mapped.csv 11299 4814 268 E49C Tryptophan synthase alpha chain Escherichia coli (strain K12) -0.01 18.17 yes Potassium phosphate 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 3299367 10.1073/pnas.84.13.4441 1987 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 11317 4814 268 E49C Tryptophan synthase alpha chain Escherichia coli (strain K12) 0.13 17.84 yes Potassium phosphate 20 mM 25.0 CD GdnHCl 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 3299367 10.1073/pnas.84.13.4441 1987 ProTherm potapov_with_uniprot_mapping.csv 11301 4815 268 E49T Tryptophan synthase alpha chain Escherichia coli (strain K12) 0.62 17.54 yes Potassium phosphate 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 3299367 10.1073/pnas.84.13.4441 1987 ProTherm 11319 4815 268 E49T Tryptophan synthase alpha chain Escherichia coli (strain K12) 0.26 17.71 yes Potassium phosphate 20 mM 25.0 CD GdnHCl 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 32.13888910081651 in tunnel in pocket 3299367 10.1073/pnas.84.13.4441 1987 ProTherm khan_protherm_data_mapped.csv 9651 4220 268 L50A Tryptophan synthase alpha chain Escherichia coli (strain K12) 0.14 5.99 2.87 Unknown 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 7.0 1WQ5 19.758749842643738 16023136 10.1016/j.jmb.2005.06.006 2005 ProTherm 9656 4220 268 L50A Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.85 1.87 0.7 Unknown 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 7.0 1WQ5 19.758749842643738 16023136 10.1016/j.jmb.2005.06.006 2005 ProTherm 25 25 268 G51D Tryptophan synthase alpha chain Escherichia coli (strain K12) -4.5 yes 55.0 Sodium phosphate 1 mM DSC Thermal 7.2 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 28.482500076293945 in pocket 1727648 10.1016/0003-9861(92)90047-z 1992 ProTherm Broom_S605.csv 21 21 268 P53H Tryptophan synthase alpha chain Escherichia coli (strain K12) -3.3 yes 56.2 Sodium phosphate 1 mM DSC Thermal 7.2 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 39.94285692487444 in pocket 1727648 10.1016/0003-9861(92)90047-z 1992 ProTherm 23 23 268 P53T Tryptophan synthase alpha chain Escherichia coli (strain K12) -4.3 yes 55.2 Sodium phosphate 1 mM DSC Thermal 7.2 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 39.94285692487444 in pocket 1727648 10.1016/0003-9861(92)90047-z 1992 ProTherm 15 15 268 D56G Tryptophan synthase alpha chain Escherichia coli (strain K12) -2.0 yes 57.5 Sodium phosphate 1 mM DSC Thermal 7.2 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 76.88499927520752 in pocket 1727648 10.1016/0003-9861(92)90047-z 1992 ProTherm 848 520 268 P57A Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.7 121.1 -0.1 yes 54.0 Sodium tetraborate 1 mM DSC Thermal 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 2008436 10.1002/prot.340090203 1991 ProTherm 7309 520 268 P57A Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.7 0.04 yes Sodium tetraborate 1 mM 54.1 EDTA 1 mM DSC Thermal 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 2008436 10.1002/prot.340090203 1991 ProTherm 10039 520 268 P57A Tryptophan synthase alpha chain Escherichia coli (strain K12) 0.48 7.73 yes Tris-HCl 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 9020793 10.1021/bi961660c 1997 ProTherm 11372 520 268 P57A Tryptophan synthase alpha chain Escherichia coli (strain K12) 0.24 4.0 yes 3.0 Tris-HCl 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 9020793 10.1021/bi961660c 1997 ProTherm 11373 520 268 P57A Tryptophan synthase alpha chain Escherichia coli (strain K12) 0.24 3.76 yes 3.0 Tris-HCl 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 9020793 10.1021/bi961660c 1997 ProTherm 17 17 268 D60G Tryptophan synthase alpha chain Escherichia coli (strain K12) -2.6 yes 56.9 Sodium phosphate 1 mM DSC Thermal 7.2 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA Proton acceptor 9.0 1WQ5 1727648 10.1016/0003-9861(92)90047-z 1992 ProTherm 12 12 268 P62Q Tryptophan synthase alpha chain Escherichia coli (strain K12) -0.6 yes 58.9 Sodium phosphate 1 mM DSC Thermal 7.2 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 7.0 1WQ5 1727648 10.1016/0003-9861(92)90047-z 1992 ProTherm 849 521 268 P62A Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.9 123.5 -1.4 yes 52.7 Sodium tetraborate 1 mM DSC Thermal 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 7.0 1WQ5 2008436 10.1002/prot.340090203 1991 ProTherm 7310 521 268 P62A Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.9 0.52 yes Sodium tetraborate 1 mM 54.1 EDTA 1 mM DSC Thermal 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 7.0 1WQ5 2008436 10.1002/prot.340090203 1991 ProTherm 10040 521 268 P62A Tryptophan synthase alpha chain Escherichia coli (strain K12) 0.31 7.89 yes Tris-HCl 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 7.0 1WQ5 9020793 10.1021/bi961660c 1997 ProTherm 11374 521 268 P62A Tryptophan synthase alpha chain Escherichia coli (strain K12) 0.69 3.54 yes 3.0 Tris-HCl 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 7.0 1WQ5 9020793 10.1021/bi961660c 1997 ProTherm 11375 521 268 P62A Tryptophan synthase alpha chain Escherichia coli (strain K12) -0.36 4.35 yes 3.0 Tris-HCl 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 7.0 1WQ5 9020793 10.1021/bi961660c 1997 ProTherm 22 22 268 T63K Tryptophan synthase alpha chain Escherichia coli (strain K12) -3.3 yes 56.2 Sodium phosphate 1 mM DSC Thermal 7.2 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8.0 1WQ5 1727648 10.1016/0003-9861(92)90047-z 1992 ProTherm 11 11 268 Q65R Tryptophan synthase alpha chain Escherichia coli (strain K12) -0.6 yes 58.9 Sodium phosphate 1 mM DSC Thermal 7.2 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 87.2044440375434 1727648 10.1016/0003-9861(92)90047-z 1992 ProTherm 18 18 268 A67V Tryptophan synthase alpha chain Escherichia coli (strain K12) -2.7 yes 56.8 Sodium phosphate 1 mM DSC Thermal 7.2 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 54.10800018310547 1727648 10.1016/0003-9861(92)90047-z 1992 ProTherm 7 7 268 P78L Tryptophan synthase alpha chain Escherichia coli (strain K12) 1.9 yes 61.4 Sodium phosphate 1 mM DSC Thermal 7.2 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 5.0 1WQ5 33.967142650059294 in pocket 1727648 10.1016/0003-9861(92)90047-z 1992 ProTherm HotMuSiC_S1626.csv 13 13 268 P78S Tryptophan synthase alpha chain Escherichia coli (strain K12) -1.6 yes 57.9 Sodium phosphate 1 mM DSC Thermal 7.2 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 5.0 1WQ5 33.967142650059294 in pocket 1727648 10.1016/0003-9861(92)90047-z 1992 ProTherm 467 261 268 C81S Tryptophan synthase alpha chain Escherichia coli (strain K12) 5.02 92.82 -4.4 yes 49.1 Sodium tetraborate 1 mM DSC Thermal 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 7.0 1WQ5 28.176666895548504 8795042 10.1093/protein/9.5.425 1996 ProTherm 468 262 268 C81G Tryptophan synthase alpha chain Escherichia coli (strain K12) 6.82 104.31 -4.8 yes 48.7 Sodium tetraborate 1 mM DSC Thermal 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 7.0 1WQ5 28.176666895548504 8795042 10.1093/protein/9.5.425 1996 ProTherm 469 263 268 C81A Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.11 83.49 -1.7 yes 51.8 Sodium tetraborate 1 mM DSC Thermal 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 7.0 1WQ5 28.176666895548504 8795042 10.1093/protein/9.5.425 1996 ProTherm 7667 263 268 C81A Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.11 0.69 0.48 yes Sodium tetraborate 1 mM 50.0 DSC Thermal 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 7.0 1WQ5 28.176666895548504 8795042 10.1093/protein/9.5.425 1996 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 470 264 268 C81V Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.31 57.42 -4.4 yes 49.1 Sodium tetraborate 1 mM DSC Thermal 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 7.0 1WQ5 28.176666895548504 8795042 10.1093/protein/9.5.425 1996 ProTherm HotMuSiC_S1626.csv 10802 4599 268 P93S Tryptophan synthase alpha chain Escherichia coli (strain K12) 5.4 4.1 yes Potassium phosphate 58 mM 25.0 NMR Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 4.0 1WQ5 25.5014283316476 in pocket 8639683 10.1021/bi951726o 1996 ProTherm 15351 7122 268 P93A, H244A Tryptophan synthase alpha chain Escherichia coli (strain K12) 5.4 3.4 yes Potassium phosphate 58 mM 25.0 NMR Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 4.0, 4.0 1WQ5 25.5014283316476, 38.20200080871582 in pocket 8639683 10.1021/bi951726o 1996 ProTherm 10803 4600 268 I95A Tryptophan synthase alpha chain Escherichia coli (strain K12) 6.2 7.9 yes Potassium phosphate 58 mM 25.0 NMR Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 6.0 1WQ5 21.913749933242798 in pocket 8639683 10.1021/bi951726o 1996 ProTherm 852 524 268 P96A Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.6 113.2 -6.3 yes 47.8 Sodium tetraborate 1 mM DSC Thermal 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 18.41571412767683 in pocket 2008436 10.1002/prot.340090203 1991 ProTherm 7313 524 268 P96A Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.6 2.0 yes Sodium tetraborate 1 mM 54.1 EDTA 1 mM DSC Thermal 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 18.41571412767683 in pocket 2008436 10.1002/prot.340090203 1991 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 10041 524 268 P96A Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.13 6.08 yes Tris-HCl 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 18.41571412767683 in pocket 9020793 10.1021/bi961660c 1997 ProTherm 10804 524 268 P96A Tryptophan synthase alpha chain Escherichia coli (strain K12) 8.6 4.9 yes Potassium phosphate 58 mM 25.0 NMR Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 18.41571412767683 in pocket 8639683 10.1021/bi951726o 1996 ProTherm 11376 524 268 P96A Tryptophan synthase alpha chain Escherichia coli (strain K12) 1.6 2.63 yes 3.0 Tris-HCl 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 18.41571412767683 in pocket 9020793 10.1021/bi961660c 1997 ProTherm 11377 524 268 P96A Tryptophan synthase alpha chain Escherichia coli (strain K12) 0.55 3.44 yes 3.0 Tris-HCl 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 18.41571412767683 in pocket 9020793 10.1021/bi961660c 1997 ProTherm 10805 4601 268 I97A Tryptophan synthase alpha chain Escherichia coli (strain K12) <4.0 yes Potassium phosphate 58 mM 25.0 NMR Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 7.0 1WQ5 17.740000009536743 8639683 10.1021/bi951726o 1996 ProTherm 9652 4221 268 L99A Tryptophan synthase alpha chain Escherichia coli (strain K12) 1.69 4.44 2.39 Unknown 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 7.0 1WQ5 17.91249990463257 16023136 10.1016/j.jmb.2005.06.006 2005 ProTherm 9657 4221 268 L99A Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.38 2.34 0.94 Unknown 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 7.0 1WQ5 17.91249990463257 16023136 10.1016/j.jmb.2005.06.006 2005 ProTherm 10806 4602 268 L100A Tryptophan synthase alpha chain Escherichia coli (strain K12) 5.2 4.7 yes Potassium phosphate 58 mM 25.0 NMR Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8.0 1WQ5 22.807499885559082 in tunnel in pocket 8639683 10.1021/bi951726o 1996 ProTherm 3 3 268 M101V Tryptophan synthase alpha chain Escherichia coli (strain K12) 7.6 yes 67.1 Sodium phosphate 1 mM DSC Thermal 7.2 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 7.0 1WQ5 27.300000190734863 in pocket 1727648 10.1016/0003-9861(92)90047-z 1992 ProTherm HotMuSiC_S1626.csv 4 4 268 M101T Tryptophan synthase alpha chain Escherichia coli (strain K12) 7.6 yes 67.1 Sodium phosphate 1 mM DSC Thermal 7.2 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 7.0 1WQ5 27.300000190734863 in pocket 1727648 10.1016/0003-9861(92)90047-z 1992 ProTherm HotMuSiC_S1626.csv 5 5 268 M101I Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.7 yes 63.2 Sodium phosphate 1 mM DSC Thermal 7.2 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 7.0 1WQ5 27.300000190734863 in pocket 1727648 10.1016/0003-9861(92)90047-z 1992 ProTherm HotMuSiC_S1626.csv 8 8 268 Y102C Tryptophan synthase alpha chain Escherichia coli (strain K12) 1.4 yes 60.9 Sodium phosphate 1 mM DSC Thermal 7.2 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 37.59416667620341 in pocket 1727648 10.1016/0003-9861(92)90047-z 1992 ProTherm HotMuSiC_S1626.csv 9 9 268 Y102H Tryptophan synthase alpha chain Escherichia coli (strain K12) 0.8 yes 60.3 Sodium phosphate 1 mM DSC Thermal 7.2 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 37.59416667620341 in pocket 1727648 10.1016/0003-9861(92)90047-z 1992 ProTherm HotMuSiC_S1626.csv 10807 4603 268 Y102A Tryptophan synthase alpha chain Escherichia coli (strain K12) 5.0 5.4 yes Potassium phosphate 58 mM 25.0 NMR Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 37.59416667620341 in pocket 8639683 10.1021/bi951726o 1996 ProTherm 4106 2080 268 K109N Tryptophan synthase alpha chain Escherichia coli (strain K12) -1.5 yes(>70%) 52.5 Sodium tetraborate 1 mM DSC Thermal 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 5.0 1WQ5 44.24111133151584 in pocket 8797836 10.1111/j.1432-1033.1996.0063h.x 1996 ProTherm 19 19 268 D112N Tryptophan synthase alpha chain Escherichia coli (strain K12) -3.1 yes 56.4 Sodium phosphate 1 mM DSC Thermal 7.2 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 4.0 1WQ5 30.84499979019165 1727648 10.1016/0003-9861(92)90047-z 1992 ProTherm 27 27 268 D112G Tryptophan synthase alpha chain Escherichia coli (strain K12) -5.1 yes 54.4 Sodium phosphate 1 mM DSC Thermal 7.2 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 4.0 1WQ5 30.84499979019165 1727648 10.1016/0003-9861(92)90047-z 1992 ProTherm 20 20 268 F114L Tryptophan synthase alpha chain Escherichia coli (strain K12) -3.3 yes 56.2 Sodium phosphate 1 mM DSC Thermal 7.2 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 21.17727297002619 in pocket 1727648 10.1016/0003-9861(92)90047-z 1992 ProTherm 16 16 268 Y115C Tryptophan synthase alpha chain Escherichia coli (strain K12) -2.3 yes 57.2 Sodium phosphate 1 mM DSC Thermal 7.2 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 5.0 1WQ5 20.019999980926514 in pocket 1727648 10.1016/0003-9861(92)90047-z 1992 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 471 265 268 C118S Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.3 75.6 -8.5 yes 45.0 Sodium tetraborate 1 mM DSC Thermal 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 7.0 1WQ5 22.833333333333332 in pocket 8795042 10.1093/protein/9.5.425 1996 ProTherm HotMuSiC_S1626.csv 472 266 268 C118A Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.3 82.3 -4.3 yes 49.2 Sodium tetraborate 1 mM DSC Thermal 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 7.0 1WQ5 22.833333333333332 in pocket 8795042 10.1093/protein/9.5.425 1996 ProTherm 473 267 268 C118V Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.42 72.97 -4.2 yes 49.3 Sodium tetraborate 1 mM DSC Thermal 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 7.0 1WQ5 22.833333333333332 in pocket 8795042 10.1093/protein/9.5.425 1996 ProTherm 9653 4222 268 L127A Tryptophan synthase alpha chain Escherichia coli (strain K12) 0.73 5.4 2.55 Unknown 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8.0 1WQ5 22.057499885559082 in pocket 16023136 10.1016/j.jmb.2005.06.006 2005 ProTherm SAAFEC_S1262.csv 9658 4222 268 L127A Tryptophan synthase alpha chain Escherichia coli (strain K12) 0.55 4.17 1.1 Unknown 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8.0 1WQ5 22.057499885559082 in pocket 16023136 10.1016/j.jmb.2005.06.006 2005 ProTherm SAAFEC_S1262.csv 850 522 268 P132A Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.8 121.2 -2.6 yes 51.5 Sodium tetraborate 1 mM DSC Thermal 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 27.04428618294852 in pocket 2008436 10.1002/prot.340090203 1991 ProTherm 7311 522 268 P132A Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.8 0.92 yes Sodium tetraborate 1 mM 54.1 EDTA 1 mM DSC Thermal 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 27.04428618294852 in pocket 2008436 10.1002/prot.340090203 1991 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 10042 522 268 P132A Tryptophan synthase alpha chain Escherichia coli (strain K12) 1.05 7.15 yes Tris-HCl 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 27.04428618294852 in pocket 9020793 10.1021/bi961660c 1997 ProTherm 11378 522 268 P132A Tryptophan synthase alpha chain Escherichia coli (strain K12) 0.91 3.33 yes 3.0 Tris-HCl 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 27.04428618294852 in pocket 9020793 10.1021/bi961660c 1997 ProTherm 11379 522 268 P132A Tryptophan synthase alpha chain Escherichia coli (strain K12) -0.14 3.85 yes 3.0 Tris-HCl 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 27.04428618294852 in pocket 9020793 10.1021/bi961660c 1997 ProTherm 851 523 268 P132G Tryptophan synthase alpha chain Escherichia coli (strain K12) 5.1 116.6 -2.3 yes 51.8 Sodium tetraborate 1 mM DSC Thermal 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 27.04428618294852 in pocket 2008436 10.1002/prot.340090203 1991 ProTherm HotMuSiC_S1626.csv 7312 523 268 P132G Tryptophan synthase alpha chain Escherichia coli (strain K12) 5.1 0.78 yes Sodium tetraborate 1 mM 54.1 EDTA 1 mM DSC Thermal 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 27.04428618294852 in pocket 2008436 10.1002/prot.340090203 1991 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8864 523 268 P132G Tryptophan synthase alpha chain Escherichia coli (strain K12) 1.0 3.6 yes 3.0 Potassium phosphate 10 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 27.04428618294852 in pocket 2008436 10.1002/prot.340090203 1991 ProTherm 8865 523 268 P132G Tryptophan synthase alpha chain Escherichia coli (strain K12) -0.4 4.6 yes 3.0 Potassium phosphate 10 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 27.04428618294852 in pocket 2008436 10.1002/prot.340090203 1991 ProTherm SAAFEC_S1262.csv 11354 523 268 P132G Tryptophan synthase alpha chain Escherichia coli (strain K12) 0.6 8.2 yes Potassium phosphate 10 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 27.04428618294852 in pocket 2008436 10.1002/prot.340090203 1991 ProTherm 10820 4607 268 F139W Tryptophan synthase alpha chain Escherichia coli (strain K12) 5.6 yes 3.0 Potassium phosphate 10 mM 25.0 Fluorescence Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 5.0 1WQ5 21.885454524647106 in pocket 7499309 10.1074/jbc.270.47.28177 1995 ProTherm 10821 4607 268 F139W Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.9 yes 3.0 Potassium phosphate 10 mM 25.0 Fluorescence Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 5.0 1WQ5 21.885454524647106 in pocket 7499309 10.1074/jbc.270.47.28177 1995 ProTherm 12570 4607 268 F139W Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.46 0.7 5.7 2.3 yes 3.0 Potassium phosphate 10 mM 23.0 Absorbance Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 5.0 1WQ5 21.885454524647106 in pocket 7629069 10.1074/jbc.270.30.17712 1995 ProTherm SAAFEC_S1262.csv 12571 4607 268 F139W Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.8 0.6 4.6 1.2 yes 3.0 Potassium phosphate 10 mM 23.0 Absorbance Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 5.0 1WQ5 21.885454524647106 in pocket 7629069 10.1074/jbc.270.30.17712 1995 ProTherm SAAFEC_S1262.csv 15469 7170 268 F139W, F258W Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.67 0.8 5.6 2.1 yes 3.0 Potassium phosphate 10 mM 23.0 Absorbance Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 5.0, 7.0 1WQ5 21.885454524647106, 31.279090881347656 in pocket 7629069 10.1074/jbc.270.30.17712 1995 ProTherm 15470 7170 268 F139W, F258W Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.51 0.8 4.4 1.3 yes 3.0 Potassium phosphate 10 mM 23.0 Absorbance Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 5.0, 7.0 1WQ5 21.885454524647106, 31.279090881347656 in pocket 7629069 10.1074/jbc.270.30.17712 1995 ProTherm 474 268 268 C154S Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.52 46.41 -8.2 yes 45.3 Sodium tetraborate 1 mM DSC Thermal 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 7.0 1WQ5 20.763333002726238 8795042 10.1093/protein/9.5.425 1996 ProTherm 475 269 268 C154A Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.11 72.97 -2.9 yes 50.6 Sodium tetraborate 1 mM DSC Thermal 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 7.0 1WQ5 20.763333002726238 8795042 10.1093/protein/9.5.425 1996 ProTherm 7668 269 268 C154A Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.11 1.03 0.14 yes Sodium tetraborate 1 mM 50.0 DSC Thermal 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 7.0 1WQ5 20.763333002726238 8795042 10.1093/protein/9.5.425 1996 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 476 270 268 C154V Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.21 71.53 -3.3 yes 50.2 Sodium tetraborate 1 mM DSC Thermal 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 7.0 1WQ5 20.763333002726238 8795042 10.1093/protein/9.5.425 1996 ProTherm 7669 270 268 C154V Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.21 1.12 0.05 yes Sodium tetraborate 1 mM 50.0 DSC Thermal 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 7.0 1WQ5 20.763333002726238 8795042 10.1093/protein/9.5.425 1996 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 10732 4563 268 Y175C Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.58 0.1 3.0 Unknown 3.0 Potassium phosphate 10 mM 25.0 Absorbance Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 23.25083335240682 in tunnel in pocket 3539187 10.1021/bi00369a002 1986 ProTherm khan_protherm_data_mapped.csv 10733 4563 268 Y175C Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.71 0.5 1.1 Unknown 3.0 Potassium phosphate 10 mM 25.0 Absorbance Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 23.25083335240682 in tunnel in pocket 3539187 10.1021/bi00369a002 1986 ProTherm 15317 7103 268 Y175C, G211E Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.2 1.3 3.0 Unknown 3.0 Potassium phosphate 10 mM 25.0 Absorbance Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0, 9.0 1WQ5 23.25083335240682, 18.21000027656555 in tunnel in pocket 3539187 10.1021/bi00369a002 1986 ProTherm 15318 7103 268 Y175C, G211E Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.49 1.0 1.4 Unknown 3.0 Potassium phosphate 10 mM 25.0 Absorbance Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0, 9.0 1WQ5 23.25083335240682, 18.21000027656555 in tunnel in pocket 3539187 10.1021/bi00369a002 1986 ProTherm 9654 4223 268 L176A Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.88 3.25 2.16 Unknown 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 7.0 1WQ5 25.352500200271606 in pocket 16023136 10.1016/j.jmb.2005.06.006 2005 ProTherm 9659 4223 268 L176A Tryptophan synthase alpha chain Escherichia coli (strain K12) 1.13 3.59 1.01 Unknown 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 7.0 1WQ5 25.352500200271606 in pocket 16023136 10.1016/j.jmb.2005.06.006 2005 ProTherm 853 525 268 P207A Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.9 95.0 -6.7 yes 47.4 Sodium tetraborate 1 mM DSC Thermal 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 23.28571401323591 in pocket 2008436 10.1002/prot.340090203 1991 ProTherm 7314 525 268 P207A Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.9 1.64 yes Sodium tetraborate 1 mM 54.1 EDTA 1 mM DSC Thermal 9.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 23.28571401323591 in pocket 2008436 10.1002/prot.340090203 1991 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8866 525 268 P207A Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.2 2.4 yes 3.0 Potassium phosphate 10 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 23.28571401323591 in pocket 2008436 10.1002/prot.340090203 1991 ProTherm 8867 525 268 P207A Tryptophan synthase alpha chain Escherichia coli (strain K12) -0.4 4.6 yes 3.0 Potassium phosphate 10 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 23.28571401323591 in pocket 2008436 10.1002/prot.340090203 1991 ProTherm 10043 525 268 P207A Tryptophan synthase alpha chain Escherichia coli (strain K12) 1.17 7.03 yes Tris-HCl 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 23.28571401323591 in pocket 9020793 10.1021/bi961660c 1997 ProTherm 11355 525 268 P207A Tryptophan synthase alpha chain Escherichia coli (strain K12) 1.8 7.0 yes Potassium phosphate 10 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 23.28571401323591 in pocket 2008436 10.1002/prot.340090203 1991 ProTherm 11380 525 268 P207A Tryptophan synthase alpha chain Escherichia coli (strain K12) 1.79 2.44 yes 3.0 Tris-HCl 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 23.28571401323591 in pocket 9020793 10.1021/bi961660c 1997 ProTherm 11381 525 268 P207A Tryptophan synthase alpha chain Escherichia coli (strain K12) -0.62 4.62 yes 3.0 Tris-HCl 20 mM 25.0 CD GdnHCl 7.0 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 23.28571401323591 in pocket 9020793 10.1021/bi961660c 1997 ProTherm 4281 2181 268 G211R Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.8 111.0 113.0 0.2 yes 58.0 Sodium phosphate 1 mM DSC Thermal 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 18.21000027656555 in tunnel in pocket 6992862 10.1021/bi00548a004 1980 ProTherm potapov_with_uniprot_mapping.csv 7159 2181 268 G211R Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.8 -0.1 yes Sodium phosphate 1 mM 57.8 EDTA 0.2 mM DSC Thermal 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 18.21000027656555 in tunnel in pocket 6992862 10.1021/bi00548a004 1980 ProTherm potapov_with_uniprot_mapping.csv, khan_protherm_data_mapped.csv 14308 2181 268 G211R Tryptophan synthase alpha chain Escherichia coli (strain K12) 1.4 2.8 2.2 1.6 Unknown Potassium phosphate 10 mM 4.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 18.21000027656555 in tunnel in pocket 2185841 10.1021/bi00458a027 1990 ProTherm potapov_with_uniprot_mapping.csv 14309 2181 268 G211R Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.28 -1.3 7.3 2.2 Unknown Potassium phosphate 10 mM 4.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 18.21000027656555 in tunnel in pocket 2185841 10.1021/bi00458a027 1990 ProTherm potapov_with_uniprot_mapping.csv 4282 2182 268 G211E Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.7 109.0 107.0 1.8 yes 59.6 Sodium phosphate 1 mM DSC Thermal 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 18.21000027656555 in tunnel in pocket 6992862 10.1021/bi00548a004 1980 ProTherm 7160 2182 268 G211E Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.7 -0.6 yes Sodium phosphate 1 mM 57.8 EDTA 0.2 mM DSC Thermal 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 18.21000027656555 in tunnel in pocket 6992862 10.1021/bi00548a004 1980 ProTherm 10459 2182 268 G211E Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.73 -2.4 8.1 3.0 yes (>90%) 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 18.21000027656555 in tunnel in pocket 2872918 10.1021/bi00358a035 1986 ProTherm 10460 2182 268 G211E Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.72 -0.4 5.4 1.5 yes (>90%) 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 18.21000027656555 in tunnel in pocket 2872918 10.1021/bi00358a035 1986 ProTherm 10715 2182 268 G211E Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.73 -2.4 8.1 3.0 Unknown Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 18.21000027656555 in tunnel in pocket 2185841 10.1021/bi00458a027 1990 ProTherm 10716 2182 268 G211E Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.72 -0.5 5.5 1.5 Unknown Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 18.21000027656555 in tunnel in pocket 2185841 10.1021/bi00458a027 1990 ProTherm 10734 2182 268 G211E Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.73 -0.3 3.0 Unknown 3.0 Potassium phosphate 10 mM 25.0 Absorbance Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 18.21000027656555 in tunnel in pocket 3539187 10.1021/bi00369a002 1986 ProTherm khan_protherm_data_mapped.csv 10735 2182 268 G211E Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.72 0.7 1.5 Unknown 3.0 Potassium phosphate 10 mM 25.0 Absorbance Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 18.21000027656555 in tunnel in pocket 3539187 10.1021/bi00369a002 1986 ProTherm 10717 4559 268 G211D Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.7 0.3 5.4 2.0 Unknown Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 18.21000027656555 in tunnel in pocket 2185841 10.1021/bi00458a027 1990 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 10718 4559 268 G211D Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.61 0.8 4.2 1.2 Unknown Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 18.21000027656555 in tunnel in pocket 2185841 10.1021/bi00458a027 1990 ProTherm 10719 4560 268 G211S Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.46 -0.2 5.9 2.4 Unknown Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 18.21000027656555 in tunnel in pocket 2185841 10.1021/bi00458a027 1990 ProTherm khan_protherm_data_mapped.csv, SAAFEC_S1262.csv 10720 4560 268 G211S Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.97 -0.2 5.2 1.3 Unknown Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 18.21000027656555 in tunnel in pocket 2185841 10.1021/bi00458a027 1990 ProTherm khan_protherm_data_mapped.csv, SAAFEC_S1262.csv 10721 4561 268 G211V Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.78 0.3 5.4 1.9 Unknown Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 18.21000027656555 in tunnel in pocket 2185841 10.1021/bi00458a027 1990 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 10722 4561 268 G211V Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.3 -1.9 6.9 1.6 Unknown Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 18.21000027656555 in tunnel in pocket 2185841 10.1021/bi00458a027 1990 ProTherm 10723 4562 268 G211W Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.25 1.6 4.1 1.8 Unknown Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 18.21000027656555 in tunnel in pocket 2185841 10.1021/bi00458a027 1990 ProTherm 10724 4562 268 G211W Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.62 1.1 3.9 1.1 Unknown Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 18.21000027656555 in tunnel in pocket 2185841 10.1021/bi00458a027 1990 ProTherm 10461 4408 268 G234D Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.78 -1.4 7.1 2.6 yes (>90%) 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 25.90750026702881 in tunnel in pocket 2872918 10.1021/bi00358a035 1986 ProTherm 10462 4408 268 G234D Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.99 -2.0 7.0 1.8 yes (>90%) 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 25.90750026702881 in tunnel in pocket 2872918 10.1021/bi00358a035 1986 ProTherm 10463 4409 268 G234K Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.65 -0.5 6.2 2.3 yes (>90%) 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 25.90750026702881 in tunnel in pocket 2872918 10.1021/bi00358a035 1986 ProTherm 10464 4409 268 G234K Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.81 0.3 4.7 1.2 yes (>90%) 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 1WQ5 25.90750026702881 in tunnel in pocket 2872918 10.1021/bi00358a035 1986 ProTherm 14189 6583 268 H244A Tryptophan synthase alpha chain Escherichia coli (strain K12) 4.8 4.0 yes Potassium phosphate 58 mM 5.0 NMR Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 4.0 1WQ5 38.20200080871582 8639683 10.1021/bi951726o 1996 ProTherm 10822 4608 268 F258W Tryptophan synthase alpha chain Escherichia coli (strain K12) 7.0 yes Potassium phosphate 10 mM 25.0 Fluorescence Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 7.0 1WQ5 31.279090881347656 7499309 10.1074/jbc.270.47.28177 1995 ProTherm 12572 4608 268 F258W Tryptophan synthase alpha chain Escherichia coli (strain K12) 2.68 1.4 5.0 1.9 yes 3.0 Potassium phosphate 10 mM 23.0 Absorbance Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 7.0 1WQ5 31.279090881347656 7629069 10.1074/jbc.270.30.17712 1995 ProTherm 12573 4608 268 F258W Tryptophan synthase alpha chain Escherichia coli (strain K12) 3.58 1.0 4.2 1.2 yes 3.0 Potassium phosphate 10 mM 23.0 Absorbance Urea 7.8 4.2.1.20 P0A877 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 7.0 1WQ5 31.279090881347656 7629069 10.1074/jbc.270.30.17712 1995 ProTherm 17404 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 96.56 yes 57.2 sodium acetate, calcium acetate 20 mM, 2 mM Mops 50 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8125111 10.1111/j.1432-1033.1994.tb18652.x 1994 ProTherm 17482 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 126.67 Unknown 52.3 Unknown NMR Thermal 4.4 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7915996 10.1016/0014-5793(94)00890-6 1994 ProTherm 17516 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.35 95.5 118.4 yes 48.91 PIPES 30 mM NaCl 0 M DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1591247 10.1021/bi00135a019 1992 ProTherm 17517 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.93 99.5 120.4 yes 51.05 PIPES 30 mM NaCl 0.05 M DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1591247 10.1021/bi00135a019 1992 ProTherm 17518 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.6 101.4 118.6 yes 52.06 PIPES 30 mM NaCl 0.10 M DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1591247 10.1021/bi00135a019 1992 ProTherm 17519 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.31 105.2 121.0 yes 53.88 PIPES 30 mM NaCl 0.20 M DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1591247 10.1021/bi00135a019 1992 ProTherm 17520 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.4 107.4 121.4 yes 56.49 PIPES 30 mM NaCl 0.40 M DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1591247 10.1021/bi00135a019 1992 ProTherm 17521 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.31 110.6 121.7 yes 58.49 PIPES 30 mM NaCl 0.60 M DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1591247 10.1021/bi00135a019 1992 ProTherm 17522 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.11 110.8 124.1 yes 60.22 PIPES 30 mM NaCl 0.80 M DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1591247 10.1021/bi00135a019 1992 ProTherm 17523 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.42 112.4 125.9 yes 63.19 PIPES 30 mM NaCl 1.20 M DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1591247 10.1021/bi00135a019 1992 ProTherm 17524 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.37 114.7 125.0 yes 65.59 PIPES 30 mM NaCl 1.60 M DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1591247 10.1021/bi00135a019 1992 ProTherm 17525 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.35 95.5 118.4 yes 48.91 PIPES 30 mM MgCl2 0 M DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1591247 10.1021/bi00135a019 1992 ProTherm 17526 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.22 98.2 116.8 yes 52.44 PIPES 30 mM MgCl2 0.01 M DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1591247 10.1021/bi00135a019 1992 ProTherm 17527 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.86 98.9 116.7 yes 53.52 PIPES 30 mM MgCl2 0.02 M DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1591247 10.1021/bi00135a019 1992 ProTherm 17528 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.94 99.1 118.9 yes 54.0 PIPES 30 mM MgCl2 0.03 M DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1591247 10.1021/bi00135a019 1992 ProTherm 17529 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.02 103.7 120.3 yes 55.39 PIPES 30 mM MgCl2 0.06 M DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1591247 10.1021/bi00135a019 1992 ProTherm 17530 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.11 103.5 121.1 yes 56.56 PIPES 30 mM MgCl2 0.10 M DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1591247 10.1021/bi00135a019 1992 ProTherm 17531 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.71 104.4 122.1 yes 58.07 PIPES 30 mM MgCl2 0.20 M DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1591247 10.1021/bi00135a019 1992 ProTherm 17532 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.22 107.8 121.8 yes 60.13 PIPES 30 mM MgCl2 0.40 M DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1591247 10.1021/bi00135a019 1992 ProTherm 17533 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.07 109.4 124.7 yes 61.86 PIPES 30 mM MgCl2 0.60 M DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1591247 10.1021/bi00135a019 1992 ProTherm 17534 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.14 110.6 120.6 yes 62.97 PIPES 30 mM MgCl2 0.80 M DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1591247 10.1021/bi00135a019 1992 ProTherm 17967 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 89.63 no 58.9 acetate 50 mM DSC Thermal 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8090706 10.1002/prot.340190205 1994 ProTherm 17968 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 109.94 yes 65.6 bis-Tris-HCl 50 mM DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8090706 10.1002/prot.340190205 1994 ProTherm 17981 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 81.98 yes 39.2 glycine 0.05 M DSC Thermal 2.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1802862 10.1111/j.1399-3011.1991.tb01525.x 1991 ProTherm 17982 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 89.39 yes 45.6 glycine 0.05 M DSC Thermal 2.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1802862 10.1111/j.1399-3011.1991.tb01525.x 1991 ProTherm 17983 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 97.28 yes 50.5 glycine 0.05 M DSC Thermal 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1802862 10.1111/j.1399-3011.1991.tb01525.x 1991 ProTherm 17984 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 110.42 yes 63.3 glycine 0.05 M DSC Thermal 4.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1802862 10.1111/j.1399-3011.1991.tb01525.x 1991 ProTherm 18009 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.72 yes 23.0 HCl CD Thermal 1.6 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7849047 10.1021/bi00006a008 1995 ProTherm 18010 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.49 yes 25.8 HCl CD Thermal 1.9 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7849047 10.1021/bi00006a008 1995 ProTherm 18011 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.16 yes 28.7 HCl CD Thermal 2.08 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7849047 10.1021/bi00006a008 1995 ProTherm 18122 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 96.0 Unknown 48.3 MOPS 30 mM Fluorescence Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2663837 1989 ProTherm 18123 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 110.0 yes 50.9 MOPS 30 mM Fluorescence Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1731929 10.1021/bi00118a013 1992 ProTherm 18130 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 96.6 Yes 2.0 50.8 MOPS 30 mM CD Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9819211 10.1021/bi9815243 1998 ProTherm 18239 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) yes 59.3 Sodium formate 0.1 M NaCl 0.25 M Fluorescence Thermal 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2457027 1988 ProTherm 18240 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 117.0 yes 56.7 Sodium acetate 0.05 M Fluorescence Thermal 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 39067 1979 ProTherm 18278 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) yes 57.6 Sodium cacodylate 10 mM Absorbance Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8075073 10.1021/bi00201a021 1994 ProTherm 18305 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) yes 23.0 HCl CD Thermal 1.6 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7849047 10.1021/bi00006a008 1995 ProTherm 18306 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) yes 25.8 HCl CD Thermal 1.9 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7849047 10.1021/bi00006a008 1995 ProTherm 18307 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) yes 28.7 HCl CD Thermal 2.08 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7849047 10.1021/bi00006a008 1995 ProTherm 18314 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.89 111.5 115.1 yes 58.8 Sodium acetate 10 mM NaCl 80 mM DSC Thermal 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8136367 10.1021/bi00177a023 1994 ProTherm 18315 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.28 111.2 110.5 yes 54.1 Sodium cacodylate-HCl 10 mM NaCl 80 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8136367 10.1021/bi00177a023 1994 ProTherm 18316 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.23 106.2 111.7 yes 50.9 Sodium cacodylate-HCl 10 mM NaCl 80 mM DSC Thermal 6.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8136367 10.1021/bi00177a023 1994 ProTherm 18317 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.21 108.4 107.9 yes 48.8 Sodium cacodylate-HCl 10 mM NaCl 80 mM DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8136367 10.1021/bi00177a023 1994 ProTherm 18318 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.2 94.7 108.6 yes 43.4 Sodium borate-HCl 10 mM NaCl 80 mM DSC Thermal 8.6 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8136367 10.1021/bi00177a023 1994 ProTherm 18319 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.22 79.7 101.7 yes 40.7 glycine-NaOH 10 mM NaCl 80 mM DSC Thermal 9.7 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8136367 10.1021/bi00177a023 1994 ProTherm 18346 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 118.0 yes 63.3 Sodium acetate 0.10 M NaCl 0.10 M Absorbance Thermal 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8844858 10.1002/pro.5560050823 1996 ProTherm 18348 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.24 115.8 Unknown 64.0 acetate 30 mM DSC Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1322462 10.1016/0022-2836(92)90963-k 1992 ProTherm 18370 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) yes 44.4 Sodium acetate 50 mM Absorbance Thermal 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8634286 10.1021/bi952348q 1996 ProTherm 18371 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) yes 61.6 Sodium acetate 30 mM NaCl 0.10 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9684895 10.1002/pro.5560070716 1998 ProTherm 18372 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) yes 61.8 Sodium acetate 30 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9684895 10.1002/pro.5560070716 1998 ProTherm 18388 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 96.6 yes (>95%) 50.8 MOPS 30 mM CD Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9819211 10.1021/bi9815243 1998 ProTherm 18409 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.2 99.3 yes 52.4 glycine-HCl 0.1 M DSC Thermal 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9260280 10.1002/pro.5560060808 1997 ProTherm 18410 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.44 102.9 yes 54.7 glycine-HCl 0.1 M DSC Thermal 3.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9260280 10.1002/pro.5560060808 1997 ProTherm 18411 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.29 105.3 yes 57.0 Acetic acid-Sodium acetate 0.1 M DSC Thermal 4.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9260280 10.1002/pro.5560060808 1997 ProTherm 18412 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.17 108.9 yes 59.2 Acetic acid-Sodium acetate 0.1 M DSC Thermal 4.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9260280 10.1002/pro.5560060808 1997 ProTherm 18413 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.32 111.2 yes 61.3 Acetic acid-Sodium acetate 0.1 M DSC Thermal 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9260280 10.1002/pro.5560060808 1997 ProTherm 18414 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.39 112.4 yes 62.4 MES 0.1 M DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9260280 10.1002/pro.5560060808 1997 ProTherm 18415 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.41 126.8 yes 63.0 HEPPSO 0.1 M DSC Thermal 8.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9260280 10.1002/pro.5560060808 1997 ProTherm 18513 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.49 104.3 yes 52.8 MES 30 mM DSC Thermal 5.95 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2499351 10.1021/bi00432a026 1989 ProTherm 18514 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.72 95.2 yes 48.25 MOPS 30 mM DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2499351 10.1021/bi00432a026 1989 ProTherm 18515 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.65 87.1 yes 43.3 HEPPSO 30 mM DSC Thermal 7.9 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2499351 10.1021/bi00432a026 1989 ProTherm 18516 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.2 95.0 yes 42.6 glycine 30 mM DSC Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2499351 10.1021/bi00432a026 1989 ProTherm 18557 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) -0.4 76.9 104.3 yes 39.38 glycine 30 mM DSC Thermal 10.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1591247 10.1021/bi00135a019 1992 ProTherm 18558 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.42 76.5 113.9 yes 40.73 glycine 30 mM DSC Thermal 9.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1591247 10.1021/bi00135a019 1992 ProTherm 18559 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.88 91.6 116.0 yes 45.8 PIPES 30 mM DSC Thermal 8.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1591247 10.1021/bi00135a019 1992 ProTherm 18560 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.71 93.2 120.9 yes 46.74 PIPES 30 mM DSC Thermal 7.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1591247 10.1021/bi00135a019 1992 ProTherm 18561 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.35 95.5 118.9 yes 48.91 PIPES 30 mM DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1591247 10.1021/bi00135a019 1992 ProTherm 18562 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.69 101.0 115.6 yes 54.03 PIPES 30 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1591247 10.1021/bi00135a019 1992 ProTherm 18563 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.74 106.1 116.7 yes 56.54 acetate 30 mM DSC Thermal 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1591247 10.1021/bi00135a019 1992 ProTherm 18564 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.47 102.2 114.1 yes 56.71 acetate 30 mM DSC Thermal 4.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1591247 10.1021/bi00135a019 1992 ProTherm 18565 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.64 95.3 109.3 yes 49.05 glycine 30 mM DSC Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1591247 10.1021/bi00135a019 1992 ProTherm 18566 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.53 89.6 113.7 yes 45.43 glycine 30 mM DSC Thermal 2.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1591247 10.1021/bi00135a019 1992 ProTherm 18592 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.0 99.1 yes 60.85 Potassium acetate 50 mM DSC Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2204424 10.1021/bi00481a024 1990 ProTherm 18744 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) yes 65.0 citrate 20 mM NaCl 55 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1376620 10.1021/bi00138a006 1992 ProTherm 18771 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.6 84.7 yes 53.3 MES 30 mM DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1445858 10.1021/bi00160a033 1992 ProTherm 18791 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 106.7 Unknown 56.2 Sodium acetate 50 mM Absorbance Thermal 4.6 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8068682 10.1021/bi00200a027 1994 ProTherm 18793 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) yes (>98%) 58.8 Sodium acetate 0.01 M Fluorescence Thermal 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8347603 10.1021/bi00082a021 1993 ProTherm 18851 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 8.8 115.0 Unknown 49.9 phosphate 0.03 M Absorbance Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7918496 10.1021/bi00208a021 1994 ProTherm 18852 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 8.0 112.0 Unknown 48.3 phosphate 0.03 M Absorbance Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7918496 10.1021/bi00208a021 1994 ProTherm 18853 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 104.0 Unknown 44.3 phosphate 0.03 M Absorbance Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7918496 10.1021/bi00208a021 1994 ProTherm 18869 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.72 57.4 77.93 yes 32.56 glycine 50 mM DSC Thermal 1.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8608146 10.1021/bi952198j 1996 ProTherm 18870 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.33 62.06 78.94 yes 34.92 glycine 50 mM DSC Thermal 2.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8608146 10.1021/bi952198j 1996 ProTherm 18871 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.42 62.06 87.43 yes 38.14 glycine 50 mM DSC Thermal 2.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8608146 10.1021/bi952198j 1996 ProTherm 18872 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.53 67.54 87.26 yes 41.42 glycine 50 mM DSC Thermal 2.4 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8608146 10.1021/bi952198j 1996 ProTherm 18873 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.7 82.47 90.36 yes 45.82 glycine 50 mM DSC Thermal 2.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8608146 10.1021/bi952198j 1996 ProTherm 18874 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.42 73.57 90.35 yes 44.97 glycine 50 mM DSC Thermal 2.6 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8608146 10.1021/bi952198j 1996 ProTherm 18875 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.04 83.79 95.41 yes 48.51 glycine 50 mM DSC Thermal 2.75 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8608146 10.1021/bi952198j 1996 ProTherm 18876 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.94 76.31 93.44 yes 48.03 Citric acid 50 mM DSC Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8608146 10.1021/bi952198j 1996 ProTherm 18877 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.96 86.86 100.58 yes 50.52 Citric acid 50 mM DSC Thermal 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8608146 10.1021/bi952198j 1996 ProTherm 18878 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.08 94.8 104.32 yes 56.52 Citric acid 50 mM DSC Thermal 3.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8608146 10.1021/bi952198j 1996 ProTherm 18879 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.65 98.09 105.43 yes 58.31 Citric acid 50 mM DSC Thermal 3.7 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8608146 10.1021/bi952198j 1996 ProTherm 18880 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.71 92.89 97.29 yes 56.75 Citric acid 50 mM DSC Thermal 4.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8608146 10.1021/bi952198j 1996 ProTherm 18881 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.58 96.59 100.82 yes 58.67 Citric acid 50 mM DSC Thermal 4.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8608146 10.1021/bi952198j 1996 ProTherm 18882 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.91 101.38 104.71 yes 60.14 Citric acid 50 mM DSC Thermal 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8608146 10.1021/bi952198j 1996 ProTherm 18883 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.26 109.05 123.38 yes 65.32 Citric acid 50 mM DSC Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8608146 10.1021/bi952198j 1996 ProTherm 18884 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.92 113.71 122.36 yes 64.67 Citric acid 50 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8608146 10.1021/bi952198j 1996 ProTherm 18885 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.88 113.71 122.01 yes 64.67 Citric acid 50 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8608146 10.1021/bi952198j 1996 ProTherm 18886 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.33 115.35 123.77 yes 64.16 Citric acid 50 mM DSC Thermal 6.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8608146 10.1021/bi952198j 1996 ProTherm 18911 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 105.98 no 57.0 Potassium acetate 50 mM DSC Thermal 4.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7542026 10.1021/bi00027a011 1995 ProTherm 18939 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 97.5 no 51.9 MES 0.05 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1970567 1990 ProTherm 18983 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 97.7 yes 52.55 Sodium cacodylate 50 mM CD Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8672444 10.1021/bi952550t 1996 ProTherm 19017 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 43.3 55.74 yes(77%) 28.2 glycine-HCl 0.1 M/0.1 M NaCl 0.1 M DSC Thermal 1.1 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10211829 10.1110/ps.8.4.832 1999 ProTherm 19018 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) yes(77%) 25.9 glycine-HCl 0.1 M/0.1 M NaCl 0.1 M Absorbance Thermal 1.1 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10211829 10.1110/ps.8.4.832 1999 ProTherm 19019 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 47.61 60.53 yes(99%) 32.3 glycine-HCl 0.1 M/0.1 M NaCl 0.1 M DSC Thermal 1.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10211829 10.1110/ps.8.4.832 1999 ProTherm 19020 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) yes(99%) 28.7 glycine-HCl 0.1 M/0.1 M NaCl 0.1 M Absorbance Thermal 1.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10211829 10.1110/ps.8.4.832 1999 ProTherm 19021 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 68.9 66.27 yes(80%) 37.0 glycine-HCl 0.1 M/0.1 M NaCl 0.1 M DSC Thermal 2.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10211829 10.1110/ps.8.4.832 1999 ProTherm 19022 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) yes(80%) 33.0 glycine-HCl 0.1 M/0.1 M NaCl 0.1 M Absorbance Thermal 2.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10211829 10.1110/ps.8.4.832 1999 ProTherm 19023 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 95.69 93.06 yes(80%) 50.2 glycine-HCl 0.1 M/0.1 M NaCl 0.1 M DSC Thermal 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10211829 10.1110/ps.8.4.832 1999 ProTherm 19024 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) yes(80%) 46.1 glycine-HCl 0.1 M/0.1 M NaCl 0.1 M Absorbance Thermal 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10211829 10.1110/ps.8.4.832 1999 ProTherm 19025 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 109.57 105.98 yes(73%) 59.4 glycine-HCl 0.1 M/0.1 M NaCl 0.1 M DSC Thermal 3.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10211829 10.1110/ps.8.4.832 1999 ProTherm 19026 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) yes(73%) 52.7 glycine-HCl 0.1 M/0.1 M NaCl 0.1 M Absorbance Thermal 3.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10211829 10.1110/ps.8.4.832 1999 ProTherm 19027 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 123.21 116.27 yes(26%) 64.4 None DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10211829 10.1110/ps.8.4.832 1999 ProTherm 19028 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) yes(26%) 62.8 None Absorbance Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10211829 10.1110/ps.8.4.832 1999 ProTherm 19061 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) yes 45.0 Sodium cacodylate-D2O 100 mM Absorbance Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10024018 10.1002/(sici)1097-0134(19990215)34:3<303::aid-prot4>3.0.co;2-h 1999 ProTherm 19120 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 96.6 yes 50.8 MOPS 30 mM DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10529213 10.1021/bi991422s 1999 ProTherm 19232 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.15 85.0 yes 40.0 glycine 50 mM NaCl 200 mM DSC Thermal 2.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9878434 10.1006/jmbi.1998.2365 1999 ProTherm 19233 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.3 114.0 yes 63.7 Sodium phosphate 50 mM NaCl 200 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9878434 10.1006/jmbi.1998.2365 1999 ProTherm 19365 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 79.4 Unknown 44.9 glycine 10 mM DSC Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10422839 10.1110/ps.8.7.1500 1999 ProTherm 19366 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 82.7 Unknown 49.1 glycine 10 mM DSC Thermal 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10422839 10.1110/ps.8.7.1500 1999 ProTherm 19367 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 91.5 Unknown 54.5 acetate 10 mM DSC Thermal 3.6 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10422839 10.1110/ps.8.7.1500 1999 ProTherm 19368 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 94.2 Unknown 56.1 acetate 10 mM DSC Thermal 4.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10422839 10.1110/ps.8.7.1500 1999 ProTherm 19369 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 99.1 Unknown 58.6 acetate 10 mM DSC Thermal 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10422839 10.1110/ps.8.7.1500 1999 ProTherm 19370 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 100.7 Unknown 60.3 MOPS or HEPES 10 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10422839 10.1110/ps.8.7.1500 1999 ProTherm 19371 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 102.3 Unknown 61.8 MOPS or HEPES 10 mM DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10422839 10.1110/ps.8.7.1500 1999 ProTherm 19372 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.59 39.9 yes 12.4 MOPS 30 mM NaCl 0.1 M Fluorescence Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10386881 10.1110/ps.8.6.1314 1999 ProTherm 19373 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.56 102.7 yes 54.0 MOPS 30 mM NaCl 0.1 M Fluorescence Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10386881 10.1110/ps.8.6.1314 1999 ProTherm 19390 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 20.0 Unknown 20.2 glycine 50 mM CD Thermal 2.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8161704 10.1016/s0006-3495(94)80803-3 1994 ProTherm 19391 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 49.0 Unknown 8.3 glycine 50 mM Absorbance Thermal 2.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8161704 10.1016/s0006-3495(94)80803-3 1994 ProTherm 19392 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 24.0 Unknown 9.3 glycine 50 mM Fluorescence Thermal 2.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8161704 10.1016/s0006-3495(94)80803-3 1994 ProTherm 19411 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 93.69 Unknown 72.4 3,3'-dimethylglutaric acid (DMG) 100 mM NaCl 2 M DSC Thermal 4.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7851431 10.1111/j.1432-1033.1995.tb20418.x 1995 ProTherm 19412 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 93.21 Unknown 73.2 3,3'-dimethylglutaric acid (DMG) 100 mM NaCl 2 M DSC Thermal 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7851431 10.1111/j.1432-1033.1995.tb20418.x 1995 ProTherm 19413 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 90.2 Unknown 70.4 3,3'-dimethylglutaric acid (DMG) 100 mM NaCl 2 M DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7851431 10.1111/j.1432-1033.1995.tb20418.x 1995 ProTherm 19414 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 71.68 Unknown 66.8 3,3'-dimethylglutaric acid (DMG) 100 mM NaCl 2 M DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7851431 10.1111/j.1432-1033.1995.tb20418.x 1995 ProTherm 19415 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 63.79 Unknown 65.4 3,3'-dimethylglutaric acid (DMG) 100 mM NaCl 2 M DSC Thermal 8.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7851431 10.1111/j.1432-1033.1995.tb20418.x 1995 ProTherm 19466 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 108.8 109.89 Unknown 62.03 Potassium acetate 15 mM DSC Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1416022 10.1016/0003-2697(92)90311-t 1992 ProTherm 19480 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.9 61.2 62.0 yes 31.5 glycine 0.2 N HCl DSC Thermal 0.36 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5465355 10.1021/bi00815a015 1970 ProTherm 19481 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.02 59.0 59.0 yes 29.9 glycine 0.2 N NaCl 0.1 N DSC Thermal 1.05 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5465355 10.1021/bi00815a015 1970 ProTherm 19482 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.98 65.6 67.0 yes 31.2 glycine 0.2 N DSC Thermal 2.02 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5465355 10.1021/bi00815a015 1970 ProTherm 19483 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.11 87.7 68.0 yes 40.6 glycine 0.2 N DSC Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5465355 10.1021/bi00815a015 1970 ProTherm 19484 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.0 105.0 67.0 yes 45.8 glycine 0.2 N DSC Thermal 3.28 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5465355 10.1021/bi00815a015 1970 ProTherm 19485 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.08 126.0 64.0 no 52.3 acetate 0.2 N DSC Thermal 4.04 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5465355 10.1021/bi00815a015 1970 ProTherm 19486 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.25 151.0 60.0 no 57.8 acetate 0.2 N DSC Thermal 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5465355 10.1021/bi00815a015 1970 ProTherm 19487 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.05 155.5 66.0 no 60.8 acetate 0.2 N DSC Thermal 6.23 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5465355 10.1021/bi00815a015 1970 ProTherm 19488 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.07 168.0 88.0 no 61.3 None NaCl 0.2 N DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5465355 10.1021/bi00815a015 1970 ProTherm 19489 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.0 178.0 72.0 no 61.2 None NaCl 0.2 N DSC Thermal 7.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5465355 10.1021/bi00815a015 1970 ProTherm 19490 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 48.7 yes 25.0 HCl HCl DSC Thermal 0.36 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5465355 10.1021/bi00815a015 1970 ProTherm 19491 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 49.1 yes 25.0 HCl NaCl 0.2 N DSC Thermal 1.05 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5465355 10.1021/bi00815a015 1970 ProTherm 19492 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 53.3 yes 25.0 glycine 0.2 N DSC Thermal 2.02 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5465355 10.1021/bi00815a015 1970 ProTherm 19493 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 54.8 yes 25.0 glycine 0.2 N DSC Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5465355 10.1021/bi00815a015 1970 ProTherm 19494 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 63.4 yes 25.0 glycine 0.2 N DSC Thermal 3.28 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5465355 10.1021/bi00815a015 1970 ProTherm 19495 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 69.2 no 25.0 acetate 0.2 N DSC Thermal 4.04 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5465355 10.1021/bi00815a015 1970 ProTherm 19496 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 77.2 no 25.0 acetate 0.2 N DSC Thermal 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5465355 10.1021/bi00815a015 1970 ProTherm 19497 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 81.2 no 25.0 acetate 0.2 N DSC Thermal 6.23 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5465355 10.1021/bi00815a015 1970 ProTherm 19498 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 92.9 no 25.0 None NaCl 0.2 N DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5465355 10.1021/bi00815a015 1970 ProTherm 19499 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 105.5 no 25.0 None NaCl 0.2 N DSC Thermal 7.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5465355 10.1021/bi00815a015 1970 ProTherm 19529 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.79 43.2 yes 42.4 HCl KCl 0.15 M NMR Thermal 1.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7623385 10.1006/jmbi.1995.0408 1995 ProTherm 19751 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) yes(>90%) 63.2 phosphate DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10747991 10.1074/jbc.M001132200 2000 ProTherm 19752 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) yes(>90%) 90.0 phosphate DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10747991 10.1074/jbc.M001132200 2000 ProTherm 19908 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) yes 57.9 Sodium cacodylate 10 mM Absorbance Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8355280 10.1006/jmbi.1993.1442 1993 ProTherm 19909 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) yes 58.05 Sodium cacodylate 10 mM Absorbance Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8355280 10.1006/jmbi.1993.1442 1993 ProTherm 19910 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) yes 58.65 Sodium cacodylate 10 mM Absorbance Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8355280 10.1006/jmbi.1993.1442 1993 ProTherm 19911 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) yes 57.95 Sodium cacodylate 10 mM Absorbance Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8355280 10.1006/jmbi.1993.1442 1993 ProTherm 19923 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) Unknown 44.4 Potassium phosphate 0.1 M DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7999977 10.1016/0301-4622(94)00098-5 1994 ProTherm 20174 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.13 2.58 1.28 yes MOPS 30 mM 40.1 DSC Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1591247 10.1021/bi00135a019 1992 ProTherm 20175 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.19 2.94 yes glycine 0.05 M 40.0 DSC Thermal 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1802862 10.1111/j.1399-3011.1991.tb01525.x 1991 ProTherm 20194 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 6.6 yes(>90%) glycine 0.04 M 38.0 DSC GdnHCl 4.7 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 4368360 10.1016/0022-2836(74)90188-0 1974 ProTherm 20311 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.25 5.6 2.48 yes Sodium acetate 100 mM 35.0 Absorbance GdnHCl 4.6 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10600104 10.1021/bi9911684 1999 ProTherm 20315 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.92 3.54 1.22 yes MOPS 30 mM 34.75 DSC Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1591247 10.1021/bi00135a019 1992 ProTherm 20348 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.56 6.59 2.65 yes Sodium acetate 100 mM 30.0 Absorbance GdnHCl 4.6 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10600104 10.1021/bi9911684 1999 ProTherm 20368 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 5.45 6.51 1.18 yes MES 30 mM 29.1 DSC Urea 5.95 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2499351 10.1021/bi00432a026 1989 ProTherm 20369 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.93 4.7 1.27 yes MOPS 30 mM 29.0 DSC Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2499351 10.1021/bi00432a026 1989 ProTherm 20371 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.93 4.76 1.27 yes MOPS 30 mM 29.0 DSC Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1591247 10.1021/bi00135a019 1992 ProTherm 20372 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.95 3.52 1.19 yes HEPPSO 30 mM 28.95 DSC Urea 7.9 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2499351 10.1021/bi00432a026 1989 ProTherm 20374 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.7 Unknown glycine 10 mM 27.8 DSC Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10422839 10.1110/ps.8.7.1500 1999 ProTherm 20375 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.44 3.48 2.45 yes glycine 30 mM 27.75 DSC Urea 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2499351 10.1021/bi00432a026 1989 ProTherm 20386 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.14 4.95 1.2 yes MOPS 30 mM 27.0 DSC Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2499351 10.1021/bi00432a026 1989 ProTherm 20387 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.14 5.01 1.2 yes MOPS 30 mM 27.0 DSC Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1591247 10.1021/bi00135a019 1992 ProTherm 20402 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 14.4 yes Sodium phosphate 10 mM 26.0 KCl 0.1 M CD GdnHCl 6.45 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 4554499 10.1021/bi00760a038 1972 ProTherm 20404 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 5.92 7.07 1.15 yes MES 30 mM 25.05 DSC Urea 5.95 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2499351 10.1021/bi00432a026 1989 ProTherm 20413 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.98 yes sodium acetate, calcium acetate 20 mM, 2 mM 25.0 Mops 50 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8125111 10.1111/j.1432-1033.1994.tb18652.x 1994 ProTherm 20414 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.98 7.82 yes sodium acetate, calcium acetate 20 mM, 2 mM 25.0 Mops 50 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8125111 10.1111/j.1432-1033.1994.tb18652.x 1994 ProTherm 20503 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.59 7.43 Unknown 3,3'-dimethylglutaric acid (DMG) 100 mM 25.0 NaCl 2 M DSC Thermal 4.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7851431 10.1111/j.1432-1033.1995.tb20418.x 1995 ProTherm 20504 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.59 7.39 Unknown 3,3'-dimethylglutaric acid (DMG) 100 mM 25.0 NaCl 2 M DSC Thermal 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7851431 10.1111/j.1432-1033.1995.tb20418.x 1995 ProTherm 20505 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.59 6.91 Unknown 3,3'-dimethylglutaric acid (DMG) 100 mM 25.0 NaCl 2 M DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7851431 10.1111/j.1432-1033.1995.tb20418.x 1995 ProTherm 20506 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.59 4.54 Unknown 3,3'-dimethylglutaric acid (DMG) 100 mM 25.0 NaCl 2 M DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7851431 10.1111/j.1432-1033.1995.tb20418.x 1995 ProTherm 20507 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.59 3.63 Unknown 3,3'-dimethylglutaric acid (DMG) 100 mM 25.0 NaCl 2 M DSC Thermal 8.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7851431 10.1111/j.1432-1033.1995.tb20418.x 1995 ProTherm 20540 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.86 8.6 3.01 yes cacodylate 0.013 M 25.0 NaCl 0.1 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 3801184 10.1139/o86-132 1986 ProTherm 20541 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.9 8.8 3.04 yes cacodylate 0.013 M 25.0 KCl 0.1 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 3801184 10.1139/o86-132 1986 ProTherm 20542 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.81 8.9 3.18 yes cacodylate 0.013 M 25.0 CsCl 0.49 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 3801184 10.1139/o86-132 1986 ProTherm 20543 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.89 8.4 2.89 yes cacodylate 0.013 M 25.0 RbCl 0.50 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 3801184 10.1139/o86-132 1986 ProTherm 20544 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.83 8.5 3.02 yes cacodylate 0.013 M 25.0 NH4Cl 0.45 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 3801184 10.1139/o86-132 1986 ProTherm 20545 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.75 8.36 2.71 yes cacodylate 0.013 M 25.0 LiCi 0.50 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 3801184 10.1139/o86-132 1986 ProTherm 20546 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.57 7.8 3.13 yes cacodylate 0.013 M 25.0 LiCi 0.99 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 3801184 10.1139/o86-132 1986 ProTherm 20547 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.12 9.49 2.83 yes cacodylate 0.013 M 25.0 Na2SO4 0.15 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 3801184 10.1139/o86-132 1986 ProTherm 20548 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.34 10.15 2.59 yes cacodylate 0.013 M 25.0 Na2SO4 0.30 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 3801184 10.1139/o86-132 1986 ProTherm 20549 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.16 9.6 2.85 yes cacodylate 0.013 M 25.0 (NH4)2SO4 0.15 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 3801184 10.1139/o86-132 1986 ProTherm 20550 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.37 10.28 2.9 yes cacodylate 0.013 M 25.0 (NH4)2SO4 0.30 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 3801184 10.1139/o86-132 1986 ProTherm 20551 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.16 9.6 2.82 yes cacodylate 0.013 M 25.0 Li2SO4 0.20 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 3801184 10.1139/o86-132 1986 ProTherm 20552 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.35 10.18 2.82 yes cacodylate 0.013 M 25.0 Li2SO4 0.40 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 3801184 10.1139/o86-132 1986 ProTherm 20553 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.53 7.7 3.42 yes cacodylate 0.013 M 25.0 NaBr 0.50 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 3801184 10.1139/o86-132 1986 ProTherm 20554 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.27 6.91 2.97 yes cacodylate 0.013 M 25.0 NaBr 0.99 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 3801184 10.1139/o86-132 1986 ProTherm 20555 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.15 6.55 3.14 yes cacodylate 0.013 M 25.0 LiBr 0.76 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 3801184 10.1139/o86-132 1986 ProTherm 20556 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.48 4.51 3.41 yes cacodylate 0.013 M 25.0 LiBr 1.52 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 3801184 10.1139/o86-132 1986 ProTherm 20557 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.39 7.27 3.11 yes cacodylate 0.013 M 25.0 NaSCN 0.25 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 3801184 10.1139/o86-132 1986 ProTherm 20558 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.91 5.8 2.93 yes cacodylate 0.013 M 25.0 NaSCN 0.49 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 3801184 10.1139/o86-132 1986 ProTherm 20559 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.72 8.27 3.05 yes cacodylate 0.013 M 25.0 LiSCN 0.09 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 3801184 10.1139/o86-132 1986 ProTherm 20560 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.06 6.25 2.87 yes cacodylate 0.013 M 25.0 LiSCN 0.34 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 3801184 10.1139/o86-132 1986 ProTherm 20561 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.34 4.08 3.08 yes cacodylate 0.013 M 25.0 LiSCN 0.69 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 3801184 10.1139/o86-132 1986 ProTherm 20597 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.53 5.62 1.24 Unknown MOPS 30 mM 25.0 Fluorescence Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2663837 1989 ProTherm 20598 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 5.3 1.21 yes MOPS 30 mM 25.0 Fluorescence Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1731929 10.1021/bi00118a013 1992 ProTherm 20601 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 5.2 6.09 1.17 Yes 2.0 MOPS 30 mM 25.0 Fluorescence Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9819211 10.1021/bi9815243 1998 ProTherm 20602 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.75 6.13 1.64 Yes 2.0 glycine 30 mM 25.0 Fluorescence Urea 2.7 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9819211 10.1021/bi9815243 1998 ProTherm 20671 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.8 5.2 2.89 yes formate 30 mM 25.0 Fluorescence GdnHCl 3.02 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2110472 10.1021/bi00462a019 1990 ProTherm 20672 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.99 9.24 3.09 yes MOPS 30 mM 25.0 Fluorescence GdnHCl 6.98 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2110472 10.1021/bi00462a019 1990 ProTherm 20673 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.57 8.4 3.27 yes glycine 30 mM 25.0 Fluorescence GdnHCl 9.89 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2110472 10.1021/bi00462a019 1990 ProTherm 20674 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.78 8.04 2.89 yes formate 30 mM 25.0 Fluorescence GdnHCl 2.92 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2110472 10.1021/bi00462a019 1990 ProTherm 20675 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.98 7.7 2.58 yes MOPS 30 mM 25.0 Fluorescence GdnHCl 6.98 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2110472 10.1021/bi00462a019 1990 ProTherm 20676 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.36 3.52 2.58 yes glycine 30 mM 25.0 Fluorescence GdnHCl 9.91 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2110472 10.1021/bi00462a019 1990 ProTherm 20677 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 5.2 yes formate 30 mM 25.0 Fluorescence Urea 3.02 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2110472 10.1021/bi00462a019 1990 ProTherm 20678 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 9.2 yes MOPS 30 mM 25.0 Fluorescence Urea 6.98 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2110472 10.1021/bi00462a019 1990 ProTherm 20679 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 8.6 yes glycine 30 mM 25.0 Fluorescence Urea 9.89 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2110472 10.1021/bi00462a019 1990 ProTherm 20680 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 6.2 yes formate 30 mM 25.0 Fluorescence Urea 2.92 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2110472 10.1021/bi00462a019 1990 ProTherm 20681 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 5.7 yes MOPS 30 mM 25.0 Fluorescence Urea 6.98 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2110472 10.1021/bi00462a019 1990 ProTherm 20682 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.9 yes glycine 30 mM 25.0 Fluorescence Urea 9.91 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2110472 10.1021/bi00462a019 1990 ProTherm 20690 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.64 10.0 2.75 yes Sodium acetate 0.1 M 25.0 Fluorescence GdnHCl 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8515459 10.1006/jmbi.1993.1336 1993 ProTherm 20691 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.4 5.91 2.46 yes Tris 0.1 M 25.0 Fluorescence GdnHCl 8.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8515459 10.1006/jmbi.1993.1336 1993 ProTherm 20711 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 6.58 8.24 1.25 Unknown MES 30 mM 25.0 NaCl 0.2 M Fluorescence Urea 6.02 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1980207 10.1021/bi00485a005 1990 ProTherm 20712 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.38 5.92 1.35 Unknown HEPPSO 30 mM 25.0 NaCl 0.2 M Fluorescence Urea 8.02 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1980207 10.1021/bi00485a005 1990 ProTherm 20729 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 5.2 6.09 1.17 yes (>95%) MOPS 30 mM 25.0 CD Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9819211 10.1021/bi9815243 1998 ProTherm 20730 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.75 6.13 1.64 yes (>95%) glycine 30 mM 25.0 CD Urea 2.7 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9819211 10.1021/bi9815243 1998 ProTherm 20740 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 10.53 yes Sodium acetate-Acetic acid 0.1 M 25.0 CD GdnHCl 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2110823 10.1021/bi00464a023 1990 ProTherm 20741 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 11.0 yes Sodium acetate-Acetic acid 0.1 M 25.0 DSC GdnHCl 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2110823 10.1021/bi00464a023 1990 ProTherm 20747 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.58 5.47 1.2 yes MOPS 30 mM 25.0 DSC Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2499351 10.1021/bi00432a026 1989 ProTherm 20748 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.44 4.11 1.28 yes HEPPSO 30 mM 25.0 DSC Urea 7.9 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2499351 10.1021/bi00432a026 1989 ProTherm 20761 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 5.5 yes MOPS 30 mM 25.0 Fluorescence Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 3134046 10.1021/bi00409a018 1988 ProTherm 20778 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.58 5.55 1.2 yes MOPS 30 mM 25.0 DSC Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1591247 10.1021/bi00135a019 1992 ProTherm 20838 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 8.13 yes (>98%) Sodium acetate 0.01 M 25.0 Fluorescence Urea 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8347603 10.1021/bi00082a021 1993 ProTherm 20862 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.42 4.48 1.85 yes beta-alanine 0.1 M 25.0 Absorbance GdnHCl 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7893674 10.1021/bi00011a035 1995 ProTherm 20863 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.4 5.78 1.7 yes beta-alanine 0.1 M 25.0 Absorbance GdnHCl 3.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7893674 10.1021/bi00011a035 1995 ProTherm 20864 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 6.49 8.82 1.36 yes Bis-Tris 0.1 M 25.0 Absorbance GdnHCl 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7893674 10.1021/bi00011a035 1995 ProTherm 20865 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 7.26 9.26 1.28 yes HEPES 0.1 M 25.0 Absorbance GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7893674 10.1021/bi00011a035 1995 ProTherm 20866 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 7.69 9.3 1.21 yes taurine 0.1 M 25.0 Absorbance GdnHCl 8.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7893674 10.1021/bi00011a035 1995 ProTherm 20890 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 8.37 no Potassium acetate 50 mM 25.0 DSC Thermal 4.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7542026 10.1021/bi00027a011 1995 ProTherm 20946 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.78 5.03 2.83 yes glycine-HCl 0.05 M 25.0 KCl 0.1-1.0 M Absorbance GdnHCl 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10029541 10.1021/bi982078m 1999 ProTherm 20947 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.05 4.07 1.98 yes glycine-HCl 0.05 M 25.0 KCl 0.10 M Absorbance Urea 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10029541 10.1021/bi982078m 1999 ProTherm 20948 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.4 4.1 1.71 yes glycine-HCl 0.05 M 25.0 KCl 0.50 M Absorbance Urea 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10029541 10.1021/bi982078m 1999 ProTherm 20949 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.82 4.49 1.59 yes glycine-HCl 0.05 M 25.0 KCl 1.00 M Absorbance Urea 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10029541 10.1021/bi982078m 1999 ProTherm 20950 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.02 4.99 1.65 yes glycine-HCl 0.05 M 25.0 KCl 1.25 M Absorbance Urea 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10029541 10.1021/bi982078m 1999 ProTherm 20951 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.41 5.26 1.54 yes glycine-HCl 0.05 M 25.0 KCl 1.50 M Absorbance Urea 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10029541 10.1021/bi982078m 1999 ProTherm 20952 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.9 3.01 1.58 yes glycine-HCl 0.05 M 25.0 KCl 0.1 M Absorbance Urea 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10029541 10.1021/bi982078m 1999 ProTherm 20953 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.39 2.45 1.76 yes glycine-HCl 0.05 M 25.0 KCl 0.1 M Absorbance Urea 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10029541 10.1021/bi982078m 1999 ProTherm 20954 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.79 1.24 1.57 yes glycine-HCl 0.05 M 25.0 KCl 0.1 M Absorbance Urea 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10029541 10.1021/bi982078m 1999 ProTherm 20955 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.47 0.82 1.73 yes glycine-HCl 0.05 M 25.0 KCl 0.1 M Absorbance Urea 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10029541 10.1021/bi982078m 1999 ProTherm 20956 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.09 0.16 1.78 yes glycine-HCl 0.05 M 25.0 KCl 0.1 M Absorbance Urea 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10029541 10.1021/bi982078m 1999 ProTherm 20973 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 5.2 6.09 1.17 yes MOPS 30 mM 25.0 DSC Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10529213 10.1021/bi991422s 1999 ProTherm 20996 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.82 7.22 2.56 yes Sodium acetate 100 mM 25.0 Absorbance GdnHCl 4.6 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10600104 10.1021/bi9911684 1999 ProTherm 21002 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 6.4 8.2 1.25 yes Sodium acetate 50 mM 25.0 Fluorescence Urea 7.4 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10600109 10.1021/bi9919450 1999 ProTherm 21105 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.3 Unknown glycine 10 mM 25.0 DSC Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10422839 10.1110/ps.8.7.1500 1999 ProTherm 21106 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 5.2 Unknown glycine 10 mM 25.0 DSC Thermal 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10422839 10.1110/ps.8.7.1500 1999 ProTherm 21107 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 6.7 Unknown acetate 10 mM 25.0 DSC Thermal 3.6 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10422839 10.1110/ps.8.7.1500 1999 ProTherm 21108 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 7.2 Unknown acetate 10 mM 25.0 DSC Thermal 4.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10422839 10.1110/ps.8.7.1500 1999 ProTherm 21109 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 8.1 Unknown acetate 10 mM 25.0 DSC Thermal 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10422839 10.1110/ps.8.7.1500 1999 ProTherm 21110 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 8.5 Unknown MOPS or HEPES 10 mM 25.0 DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10422839 10.1110/ps.8.7.1500 1999 ProTherm 21111 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 9.0 Unknown MOPS or HEPES 10 mM 25.0 DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10422839 10.1110/ps.8.7.1500 1999 ProTherm 21113 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 5.23 1.23 Unknown MOPS 30 mM 25.0 CD Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10493585 10.1110/ps.8.9.1843 1999 ProTherm 21114 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.66 1.59 Unknown glycine 30 mM 25.0 CD Urea 2.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10493585 10.1110/ps.8.9.1843 1999 ProTherm 21269 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.97 8.74 2.93 yes Unknown 25.0 KCl 0.1 M Absorbance GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1445206 10.1042/bj2870481 1992 ProTherm 21270 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.94 5.66 2.91 yes Unknown 25.0 KCl 0.1 M Absorbance GdnHCl 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1445206 10.1042/bj2870481 1992 ProTherm 21271 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.31 2.63 2.0 yes Unknown 25.0 KCl 0.1 M Absorbance GdnHCl 2.1 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1445206 10.1042/bj2870481 1992 ProTherm 21272 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.93 1.9 2.03 yes Unknown 25.0 KCl 0.1 M Absorbance GdnHCl 1.3 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1445206 10.1042/bj2870481 1992 ProTherm 21363 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.63 2.75 yes Sodium acetate 0.1 M 25.0 Fluorescence GdnHCl 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8917450 10.1111/j.1432-1033.1996.00516.x 1996 ProTherm 21364 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.4 2.46 yes PIPES 0.1 M 25.0 Fluorescence GdnHCl 8.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8917450 10.1111/j.1432-1033.1996.00516.x 1996 ProTherm 21394 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.47 1.0 54.8 Unknown glycine-HCl 30 mM 25.0 NaCl 0.10 M Absorbance Thermal 1.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9922164 10.1021/bi981688j 1998 ProTherm 21395 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.47 9.0 54.8 Unknown Sodium acetate 30 mM 25.0 NaCl 0.10 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9922164 10.1021/bi981688j 1998 ProTherm 21443 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.8 4.33 2.33 yes glycine 30 mM 24.9 DSC Urea 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2499351 10.1021/bi00432a026 1989 ProTherm 21444 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.3 Unknown glycine 10 mM 24.9 DSC Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10422839 10.1110/ps.8.7.1500 1999 ProTherm 21450 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.86 5.81 1.2 yes MOPS 30 mM 23.05 DSC Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2499351 10.1021/bi00432a026 1989 ProTherm 21451 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.86 5.89 1.2 yes MOPS 30 mM 23.05 DSC Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1591247 10.1021/bi00135a019 1992 ProTherm 21551 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 6.32 7.55 1.19 yes MES 30 mM 22.0 DSC Urea 5.95 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2499351 10.1021/bi00432a026 1989 ProTherm 21552 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.91 4.67 1.25 yes HEPPSO 30 mM 22.0 DSC Urea 7.9 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2499351 10.1021/bi00432a026 1989 ProTherm 21577 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.98 5.95 1.1 yes MOPS 30 mM 21.1 DSC Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2499351 10.1021/bi00432a026 1989 ProTherm 21578 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.02 4.85 2.43 yes glycine 30 mM 21.1 DSC Urea 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2499351 10.1021/bi00432a026 1989 ProTherm 21579 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.98 6.03 1.1 yes MOPS 30 mM 21.1 DSC Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1591247 10.1021/bi00135a019 1992 ProTherm 21580 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.9 Unknown glycine 10 mM 21.1 DSC Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10422839 10.1110/ps.8.7.1500 1999 ProTherm 21733 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 5.71 6.72 1.18 yes MOPS 30 mM 20.0 DSC Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10529213 10.1021/bi991422s 1999 ProTherm 21734 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.96 7.93 2.68 yes Sodium acetate 100 mM 20.0 Absorbance GdnHCl 4.6 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10600104 10.1021/bi9911684 1999 ProTherm 21894 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 5.26 6.29 1.21 yes MOPS 30 mM 19.2 DSC Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2499351 10.1021/bi00432a026 1989 ProTherm 21895 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 5.26 6.37 1.21 yes MOPS 30 mM 19.2 DSC Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1591247 10.1021/bi00135a019 1992 ProTherm 21896 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 6.64 7.94 1.19 yes MES 30 mM 19.05 DSC Urea 5.95 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2499351 10.1021/bi00432a026 1989 ProTherm 21897 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.19 5.01 1.11 yes HEPPSO 30 mM 19.05 DSC Urea 7.9 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2499351 10.1021/bi00432a026 1989 ProTherm 21906 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.25 5.41 2.44 yes glycine 30 mM 17.1 DSC Urea 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2499351 10.1021/bi00432a026 1989 ProTherm 21907 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 5.6 Unknown glycine 10 mM 17.1 DSC Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10422839 10.1110/ps.8.7.1500 1999 ProTherm 21916 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.86 3.68 yes HCl 15.0 CD GdnHCl 2.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7849047 10.1021/bi00006a008 1995 ProTherm 21925 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.61 Unknown Tris-HCl 0.1 M 15.0 NaCl 2.5 M CD Urea 8.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7981223 10.1021/bi00252a029 1994 ProTherm 21936 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 6.43 1.14 yes MOPS 30 mM 15.0 DSC Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10529213 10.1021/bi991422s 1999 ProTherm 21937 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 6.43 7.34 1.14 yes MOPS 30 mM 15.0 DSC Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10529213 10.1021/bi991422s 1999 ProTherm 21942 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 5.65 6.84 1.26 yes MOPS 30 mM 14.9 DSC Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1591247 10.1021/bi00135a019 1992 ProTherm 21946 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 8.43 10.1 1.2 yes Sodium formate 0.1 M 12.5 NaCl 0.25 M Fluorescence Urea 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 2457027 1988 ProTherm 21973 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.94 9.83 2.49 yes Sodium acetate 0.1 M 10.0 Fluorescence GdnHCl 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8515459 10.1006/jmbi.1993.1336 1993 ProTherm 21974 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.21 8.44 2.63 yes Tris 0.1 M 10.0 Fluorescence GdnHCl 8.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8515459 10.1006/jmbi.1993.1336 1993 ProTherm 21979 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 5.18 9.54 1.84 Unknown Sodium acetate 50 mM 10.0 Fluorescence GdnHCl 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8756488 10.1021/bi953026p 1996 ProTherm 21989 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 6.7 7.87 1.18 yes MOPS 30 mM 10.0 DSC Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10529213 10.1021/bi991422s 1999 ProTherm 22000 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.94 2.49 yes Sodium acetate 0.1 M 10.0 Fluorescence GdnHCl 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8917450 10.1111/j.1432-1033.1996.00516.x 1996 ProTherm 22001 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.21 2.63 yes PIPES 0.1 M 10.0 Fluorescence GdnHCl 8.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8917450 10.1111/j.1432-1033.1996.00516.x 1996 ProTherm 22008 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 5.86 7.1 1.17 yes MOPS 30 mM 9.98 DSC Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 1591247 10.1021/bi00135a019 1992 ProTherm 22027 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 7.04 8.32 1.18 yes MOPS 30 mM 5.0 DSC Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10529213 10.1021/bi991422s 1999 ProTherm 22029 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.85 yes MOPS 30 mM 5.0 NaCl 0.1 M Fluorescence Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10386881 10.1110/ps.8.6.1314 1999 ProTherm 22065 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.2 yes MOPS 30 mM 2.0 NaCl 0.1 M Fluorescence Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10386881 10.1110/ps.8.6.1314 1999 ProTherm 22070 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.78 1.58 yes glycine 30 mM 0.0 CD Urea 2.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9283083 10.1021/bi9707180 1997 ProTherm 22071 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.32 1.28 yes MOPS 30 mM 0.0 CD Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9283083 10.1021/bi9707180 1997 ProTherm 22079 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.31 yes MOPS 30 mM 0.0 NaCl 0.1 M Fluorescence Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 10386881 10.1110/ps.8.6.1314 1999 ProTherm 22085 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 380.0 yes 64.3 sodium acetate 5-20 mM CD Thermal 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 11141060 10.1021/bi001945w 2001 ProTherm 22086 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 426.0 yes 58.2 sodium acetate 5-20 mM Absorbance Thermal 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 11141060 10.1021/bi001945w 2001 ProTherm 22087 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) yes 61.5 sodium acetate 50 mM Absorbance Thermal 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 11274463 10.1110/ps.43001 2001 ProTherm 22188 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 99.9 Yes 62.4 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22189 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 101.58 Yes 62.3 Cacodylic acid 0.05 M KCl 0.1 M CD Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22190 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.25 106.84 Yes 60.5 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22191 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.24 103.97 Yes 58.3 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22192 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 99.9 Yes 56.3 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22193 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 97.28 Yes 54.0 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22194 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 98.23 Yes 56.0 Cacodylic acid 0.05 M KCl 0.1 M CD Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22195 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 113.77 Yes 62.9 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22196 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 115.92 Yes 63.5 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22197 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 116.87 Yes 64.6 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22198 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 118.79 Yes 65.9 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22199 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 120.46 Yes 66.1 Cacodylic acid 0.05 M KCl 0.1 M CD Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22200 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.22 113.77 Yes 63.7 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22201 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.24 114.96 Yes 64.5 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22202 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.22 118.79 Yes 65.9 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22203 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.23 121.89 Yes 66.4 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22204 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 120.46 Yes 66.5 Cacodylic acid 0.05 M KCl 0.1 M CD Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22205 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.23 108.75 Yes 61.5 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22206 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.25 104.92 Yes 60.8 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22207 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.27 103.01 Yes 59.8 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22208 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.23 98.95 Yes 58.8 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22209 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 100.14 Yes 59.0 Cacodylic acid 0.05 M KCl 0.1 M CD Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22210 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.24 108.99 Yes 61.9 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22211 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.22 104.92 Yes 61.0 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22212 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.21 101.82 Yes 60.6 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22213 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.2 100.86 Yes 59.8 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22214 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 99.43 Yes 60.0 Cacodylic acid 0.05 M KCl 0.1 M CD Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22217 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.23 Yes Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22218 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.25 Yes Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22239 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 113.7 no 63.8 phosphate 10 mM DSC Thermal 6.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 11316877 10.1110/ps.47101 2001 ProTherm 22275 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) yes(0.94) 51.2 MOPS 30 mM CD Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 11513591 10.1021/bi010565n 2001 ProTherm 22276 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) yes(0.94) 51.5 MOPS 30 mM DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 11513591 10.1021/bi010565n 2001 ProTherm 22449 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 103.11 yes 58.0 MES 50 mM Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 11926818 10.1021/bi011365e 2002 ProTherm 22450 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 107.31 yes 60.7 sodium acetate 10 mM KCl 100 mM DSC Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 11926818 10.1021/bi011365e 2002 ProTherm 22494 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) Unknown 53.7 sodium acetate 50 mM CD Thermal 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 12538908 10.1093/protein/15.11.887 2002 ProTherm 22784 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 111.66 Unknown 59.65 MES 10 mM KCl 0.1 M CD Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 12962489 10.1021/bi034499w 2003 ProTherm 22839 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.22 86.11 yes 71.6 acetate 20 mM DSC Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15178004 10.1016/j.ijbiomac.2003.11.001 2004 ProTherm 22840 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.67 96.08 yes 62.0 acetate 20 mM DSC Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15178004 10.1016/j.ijbiomac.2003.11.001 2004 ProTherm 22841 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.22 90.11 yes 61.0 acetate 20 mM DSC Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15178004 10.1016/j.ijbiomac.2003.11.001 2004 ProTherm 22842 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.36 88.43 yes 60.5 acetate 20 mM DSC Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15178004 10.1016/j.ijbiomac.2003.11.001 2004 ProTherm 22843 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.41 79.35 yes 58.5 acetate 20 mM DSC Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15178004 10.1016/j.ijbiomac.2003.11.001 2004 ProTherm 22844 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 80.54 no 55.0 acetate 20 mM DSC Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15178004 10.1016/j.ijbiomac.2003.11.001 2004 ProTherm 22845 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 76.96 no 54.6 acetate 20 mM DSC Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15178004 10.1016/j.ijbiomac.2003.11.001 2004 ProTherm 22846 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 80.54 no 51.9 acetate 20 mM DSC Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15178004 10.1016/j.ijbiomac.2003.11.001 2004 ProTherm 22847 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 77.2 no 45.5 acetate 20 mM DSC Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15178004 10.1016/j.ijbiomac.2003.11.001 2004 ProTherm 22848 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 69.79 no 43.9 acetate 20 mM DSC Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15178004 10.1016/j.ijbiomac.2003.11.001 2004 ProTherm 22849 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.41 70.27 yes 35.4 acetate 20 mM DSC Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15178004 10.1016/j.ijbiomac.2003.11.001 2004 ProTherm 22850 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.46 56.17 yes 26.8 acetate 20 mM DSC Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15178004 10.1016/j.ijbiomac.2003.11.001 2004 ProTherm 22851 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 86.11 no 71.6 acetate 20 mM DSC Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15178004 10.1016/j.ijbiomac.2003.11.001 2004 ProTherm 22852 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 67.88 no 51.3 acetate 20 mM DSC Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15178004 10.1016/j.ijbiomac.2003.11.001 2004 ProTherm 22853 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 71.94 no 52.8 acetate 20 mM DSC Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15178004 10.1016/j.ijbiomac.2003.11.001 2004 ProTherm 22854 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 74.33 no 53.4 acetate 20 mM DSC Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15178004 10.1016/j.ijbiomac.2003.11.001 2004 ProTherm 22855 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 81.5 no 55.4 acetate 20 mM DSC Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15178004 10.1016/j.ijbiomac.2003.11.001 2004 ProTherm 22856 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 78.15 no 56.6 acetate 20 mM DSC Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15178004 10.1016/j.ijbiomac.2003.11.001 2004 ProTherm 23286 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 66.0 Yes (>90%) 62.8 None Absorbance Thermal 7.1 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16953565 10.1021/bi060933t 2006 ProTherm 23287 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 112.0 Yes (>90%) 61.7 MOPS 20 mM CD Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16953565 10.1021/bi060933t 2006 ProTherm 23288 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 122.0 Yes (>90%) 61.37 None CD Thermal 7.1 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16953565 10.1021/bi060933t 2006 ProTherm 23336 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 104.45 Yes 58.0 Sodium acetate 50 mM Absorbance Thermal 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16542150 10.1515/BC.2006.038 2006 ProTherm 23384 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) Unknown 62.9 Potassium phosphate 10 mM CD Thermal 6.4 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17123958 10.1110/ps.062393707 2007 ProTherm 23385 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) Unknown 48.0 Potassium phosphate 10 mM CD Thermal 6.4 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17123958 10.1110/ps.062393707 2007 ProTherm 23386 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) Unknown 50.2 Potassium phosphate 10 mM CD Thermal 6.4 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17123958 10.1110/ps.062393707 2007 ProTherm 23455 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) Unknown 62.6 Tris, Gly 25 mM, 192 mM NaCl 30 mM Capillary electrophoresis Thermal 8.4 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17234323 10.1016/j.bpc.2006.12.004 2007 ProTherm 23456 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) Unknown 63.6 Tris, Gly, sucrose 25 mM, 192 mM, 0.15 M NaCl 30 mM Capillary electrophoresis Thermal 8.4 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17234323 10.1016/j.bpc.2006.12.004 2007 ProTherm 23457 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) Unknown 64.7 Tris, Gly, sucrose 25 mM, 192 mM, 0.31 M NaCl 30 mM Capillary electrophoresis Thermal 8.4 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17234323 10.1016/j.bpc.2006.12.004 2007 ProTherm 23458 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) Unknown 65.9 Tris, Gly, sucrose 25 mM, 192 mM, 0.47 M NaCl 30 mM Capillary electrophoresis Thermal 8.4 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17234323 10.1016/j.bpc.2006.12.004 2007 ProTherm 23459 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) Unknown 66.5 Tris, Gly, sucrose 25 mM, 192 mM, 0.63 M NaCl 30 mM Capillary electrophoresis Thermal 8.4 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17234323 10.1016/j.bpc.2006.12.004 2007 ProTherm 23460 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) Unknown 67.1 Tris, Gly, sucrose 25 mM, 192 mM, 0.80 M NaCl 30 mM Capillary electrophoresis Thermal 8.4 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17234323 10.1016/j.bpc.2006.12.004 2007 ProTherm 23461 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) Unknown 63.9 Tris, Gly, fructose 25 mM, 192 mM, 0.29 M NaCl 30 mM Capillary electrophoresis Thermal 8.4 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17234323 10.1016/j.bpc.2006.12.004 2007 ProTherm 23462 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) Unknown 64.5 Tris, Gly, fructose 25 mM, 192 mM, 0.57 M NaCl 30 mM Capillary electrophoresis Thermal 8.4 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17234323 10.1016/j.bpc.2006.12.004 2007 ProTherm 23463 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) Unknown 66.0 Tris, Gly, fructose 25 mM, 192 mM, 0.89 M NaCl 30 mM Capillary electrophoresis Thermal 8.4 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17234323 10.1016/j.bpc.2006.12.004 2007 ProTherm 23464 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) Unknown 66.5 Tris, Gly, fructose 25 mM, 192 mM, 1.21 M NaCl 30 mM Capillary electrophoresis Thermal 8.4 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17234323 10.1016/j.bpc.2006.12.004 2007 ProTherm 23465 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) Unknown 68.0 Tris, Gly, fructose 25 mM, 192 mM, 1.52 M NaCl 30 mM Capillary electrophoresis Thermal 8.4 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17234323 10.1016/j.bpc.2006.12.004 2007 ProTherm 23475 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.3 98.0 Unknown 62.45 Tris, Gly 25 mM, 192 mM NaCl 30 mM Capillary electrophoresis Thermal 8.4 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17234323 10.1016/j.bpc.2006.12.004 2007 ProTherm 23516 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 123.33 unknown 59.75 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23517 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 134.35 unknown 62.15 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23518 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 137.19 unknown 64.05 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23519 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 146.01 unknown 65.55 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23520 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 165.68 unknown 67.75 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23521 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 119.02 unknown 59.65 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23522 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 120.67 unknown 62.25 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23523 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 121.73 unknown 64.35 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23524 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 119.41 unknown 66.45 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23525 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 133.32 unknown 67.95 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23526 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 119.1 unknown 59.65 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23527 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 116.52 unknown 61.95 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23528 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 122.01 unknown 64.15 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23529 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 122.13 unknown 65.85 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23530 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 131.67 unknown 67.35 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23531 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 141.42 unknown 61.55 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23532 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 143.76 unknown 63.25 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23533 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 145.15 unknown 64.95 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23534 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 147.32 unknown 66.15 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23535 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 171.25 unknown 60.15 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23536 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 193.79 unknown 60.35 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23537 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 219.55 unknown 60.75 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23538 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 247.63 unknown 61.15 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23539 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 110.01 unknown 57.95 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23540 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 117.28 unknown 60.35 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23541 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 122.3 unknown 62.65 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23542 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 124.55 unknown 64.55 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23543 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 130.9 unknown 66.45 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23544 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 107.72 unknown 57.45 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23545 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 110.13 unknown 60.25 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23546 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 111.09 unknown 62.75 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23547 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 122.01 unknown 65.05 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23548 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 118.86 unknown 67.95 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23549 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 110.06 unknown 60.25 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23550 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 114.79 unknown 62.75 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23551 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 121.39 unknown 64.45 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23552 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 121.65 unknown 66.55 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23553 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 123.9 unknown 59.75 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23554 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 121.08 unknown 61.45 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23555 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 129.28 unknown 62.95 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23556 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 125.48 unknown 64.15 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23557 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 120.0 unknown 58.75 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23558 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 132.29 unknown 58.95 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23559 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 144.5 unknown 59.55 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23560 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 142.95 unknown 60.05 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23561 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 96.46 unknown 48.95 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23562 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 112.83 unknown 52.05 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23563 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 115.82 unknown 55.95 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23564 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 127.94 unknown 57.85 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23565 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 129.37 unknown 60.05 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23566 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 99.26 unknown 49.05 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23567 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 102.06 unknown 52.35 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23568 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 107.24 unknown 56.15 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23569 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 108.27 unknown 58.75 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23570 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 111.14 unknown 60.85 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23571 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 98.69 unknown 59.05 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23572 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 103.42 unknown 51.15 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23573 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 103.92 unknown 54.05 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23574 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 109.89 unknown 56.65 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23575 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 112.07 unknown 59.15 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23576 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 103.04 unknown 51.35 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23577 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 108.29 unknown 53.35 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23578 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 107.0 unknown 55.35 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23579 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 112.4 unknown 57.15 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23580 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 104.68 unknown 49.25 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23581 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 111.35 unknown 50.15 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23582 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 116.97 unknown 50.45 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23583 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 127.56 unknown 51.05 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23729 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 104.8 Unknown 61.1 PBS CD Thermal 7.4 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17656580 10.1110/ps.072938907 2007 ProTherm 23797 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.5 70.03 Yes 44.9 Glycine-HCl 0.1 M KCl 0.1 M CD Thermal 2.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 18201812 10.1016/j.bpc.2007.12.006 2008 ProTherm 23800 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.65 70.03 Yes 45.3 Glycine-HCl 0.1 M KCl 0.1 M CD Thermal 2.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 18201812 10.1016/j.bpc.2007.12.006 2008 ProTherm 23804 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 51.86 Yes 31.5 Glycine-HCl 0.1 M KCl 0.1 M CD Thermal 2.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 18201812 10.1016/j.bpc.2007.12.006 2008 ProTherm 23805 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 44.93 Yes 27.5 Glycine-HCl 0.1 M KCl 0.1 M CD Thermal 2.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 18201812 10.1016/j.bpc.2007.12.006 2008 ProTherm 23806 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 39.91 Yes 25.5 Glycine-HCl 0.1 M KCl 0.1 M CD Thermal 2.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 18201812 10.1016/j.bpc.2007.12.006 2008 ProTherm 23807 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 34.89 Yes 22.5 Glycine-HCl 0.1 M KCl 0.1 M CD Thermal 2.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 18201812 10.1016/j.bpc.2007.12.006 2008 ProTherm 23816 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 54.97 Yes 33.5 Glycine-HCl 0.1 M KCl 0.1 M CD Thermal 2.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 18201812 10.1016/j.bpc.2007.12.006 2008 ProTherm 23817 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 49.0 Yes 30.3 Glycine-HCl 0.1 M KCl 0.1 M CD Thermal 2.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 18201812 10.1016/j.bpc.2007.12.006 2008 ProTherm 23818 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 41.83 Yes 27.7 Glycine-HCl 0.1 M KCl 0.1 M CD Thermal 2.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 18201812 10.1016/j.bpc.2007.12.006 2008 ProTherm 23819 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 38.0 Yes 25.3 Glycine-HCl 0.1 M KCl 0.1 M CD Thermal 2.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 18201812 10.1016/j.bpc.2007.12.006 2008 ProTherm 23954 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 119.02 Unknown 59.65 Acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23955 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 120.67 Unknown 62.25 Acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23956 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 121.73 Unknown 64.35 Acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23957 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 119.41 Unknown 66.45 Acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23958 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 133.32 Unknown 67.95 Acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23959 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 134.35 Unknown 62.15 Acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23960 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 137.19 Unknown 64.05 Acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23961 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 146.01 Unknown 65.55 Acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23962 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 165.68 Unknown 67.75 Acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23963 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 141.42 Unknown 61.55 Acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23964 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 143.76 Unknown 63.25 Acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23965 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 145.15 Unknown 64.95 Acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23966 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 147.32 Unknown 66.15 Acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23967 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 171.25 Unknown 60.15 Acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23968 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 193.79 Unknown 60.35 Acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23969 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 219.55 Unknown 60.75 Acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23970 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 247.63 Unknown 61.15 Acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23971 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 149.76 Unknown 57.75 Acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23972 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 135.13 Unknown 55.95 Acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23973 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 127.06 Unknown 54.15 Acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23974 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 121.61 Unknown 52.35 Acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23975 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 136.16 Unknown 55.45 Acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23976 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 124.78 Unknown 51.05 Acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23977 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 113.22 Unknown 46.75 Acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23978 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 109.03 Unknown 42.55 Acetate 0.04 M Absorbance Thermal 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23979 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 107.72 Unknown 57.45 Acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23980 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 110.13 Unknown 60.25 Acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23981 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 111.09 Unknown 62.75 Acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23982 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 122.01 Unknown 65.05 Acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23983 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 118.86 Unknown 67.95 Acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23984 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 117.28 Unknown 60.35 Acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23985 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 122.3 Unknown 62.65 Acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23986 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 124.55 Unknown 64.55 Acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23987 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 130.9 Unknown 66.45 Acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23988 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 123.9 Unknown 59.75 Acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23989 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 121.08 Unknown 61.45 Acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23990 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 129.28 Unknown 62.95 Acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23991 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 125.48 Unknown 64.15 Acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23992 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 120.0 Unknown 58.75 Acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23993 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 132.29 Unknown 58.95 Acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23994 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 144.5 Unknown 59.55 Acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23995 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 142.95 Unknown 60.05 Acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23996 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 132.58 Unknown 54.85 Acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23997 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 132.31 Unknown 53.25 Acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23998 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 110.28 Unknown 50.95 Acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 23999 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 108.58 Unknown 48.95 Acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24000 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 126.96 Unknown 52.05 Acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24001 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 123.37 Unknown 48.15 Acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24002 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 106.96 Unknown 44.05 Acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24003 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 99.07 Unknown 40.15 Acetate 0.04 M Absorbance Thermal 4.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24004 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 99.26 Unknown 49.05 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24005 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 102.06 Unknown 52.35 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24006 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 107.24 Unknown 56.15 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24007 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 108.27 Unknown 58.75 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24008 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 111.14 Unknown 60.85 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24009 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 112.83 Unknown 52.05 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24010 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 115.82 Unknown 55.95 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24011 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 127.94 Unknown 57.85 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24012 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 129.37 Unknown 60.05 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24013 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 103.04 Unknown 51.35 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24014 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 108.29 Unknown 53.35 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24015 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 107.0 Unknown 55.35 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24016 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 112.4 Unknown 57.15 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24017 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 104.68 Unknown 49.25 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24018 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 111.35 Unknown 50.15 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24019 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 116.97 Unknown 50.45 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24020 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 127.56 Unknown 51.05 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24021 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 113.38 Unknown 43.75 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24022 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 110.13 Unknown 43.15 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24023 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 104.78 Unknown 35.95 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24024 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 112.6 Unknown 32.35 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24025 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 108.17 Unknown 41.45 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24026 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 97.28 Unknown 37.15 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24027 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 104.09 Unknown 33.15 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24028 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 117.78 Unknown 29.45 Glycine-HCl 0.04 M Absorbance Thermal 2.8 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24075 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) Yes 65.6 Sodium phosphate 50 mM NaCl 25 mM CD Thermal 8.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19155118 10.1016/j.bpc.2008.12.005 2009 ProTherm 24340 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 107.0 yes 2.0 52.5 MOPS 30000.0 DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 24591301 10.1002/pro.2449 2014 ProTherm 25323 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 5.06 Yes Sodium acetate 50 mM 40.0 Absorbance Thermal 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16542150 10.1515/BC.2006.038 2006 ProTherm 25603 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 9.59 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25604 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 9.57 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25605 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 9.44 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25606 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 8.3 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25607 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 7.6 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25608 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 6.96 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25609 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 6.99 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25610 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 10.06 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25611 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 10.53 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25612 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 10.94 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25613 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 11.47 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25614 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 11.5 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25615 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 10.24 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25616 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 10.69 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25617 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 11.19 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25618 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 11.59 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25619 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 11.49 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25620 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 9.33 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25621 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 9.79 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25622 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 8.24 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25623 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 7.9 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25624 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 7.92 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25625 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 9.39 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25626 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 8.89 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25627 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 8.39 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25628 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 8.09 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25629 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 8.11 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25720 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 7.16 10.66 1.49 Unknown Glycinamide 0.1 M 25.0 Absorbance Urea 6.35 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 12741842 10.1021/bi0206457 2003 ProTherm 25721 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 7.59 10.93 1.45 Unknown Glycinamide 0.1 M 25.0 Absorbance Urea 7.05 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 12741842 10.1021/bi0206457 2003 ProTherm 25722 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.52 Unknown Glycinamide 0.1 M 25.0 Absorbance Urea 6.35 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 12741842 10.1021/bi0206457 2003 ProTherm 25723 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.97 Unknown Glycinamide 0.1 M 25.0 Absorbance Urea 7.05 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 12741842 10.1021/bi0206457 2003 ProTherm 25777 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.48 3.28 2.24 yes Glycine-HCl 3 mM 25.0 CD Urea 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 12070329 10.1110/ps.0205902 2002 ProTherm 25778 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.43 3.26 2.29 yes Glycine-HCl 3 mM 25.0 NaCl 0.01 M CD Urea 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 12070329 10.1110/ps.0205902 2002 ProTherm 25779 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.0 3.69 1.85 yes Glycine-HCl 3 mM 25.0 NaCl 0.25 M CD Urea 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 12070329 10.1110/ps.0205902 2002 ProTherm 25780 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.49 4.48 1.8 yes Glycine-HCl 3 mM 25.0 NaCl 0.50 M CD Urea 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 12070329 10.1110/ps.0205902 2002 ProTherm 25781 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.91 5.07 1.75 yes Glycine-HCl 3 mM 25.0 NaCl 0.75 M CD Urea 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 12070329 10.1110/ps.0205902 2002 ProTherm 25782 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.21 5.28 1.64 yes Glycine-HCl 3 mM 25.0 NaCl 1.00 M CD Urea 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 12070329 10.1110/ps.0205902 2002 ProTherm 25783 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.55 4.2 1.67 yes Glycine-HCl 3 mM 25.0 Na2SO4 0.01 M CD Urea 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 12070329 10.1110/ps.0205902 2002 ProTherm 25784 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.21 6.38 1.52 yes Glycine-HCl 3 mM 25.0 Na2SO4 0.20 M CD Urea 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 12070329 10.1110/ps.0205902 2002 ProTherm 25785 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 5.28 7.91 1.5 yes Glycine-HCl 3 mM 25.0 Na2SO4 0.50 M CD Urea 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 12070329 10.1110/ps.0205902 2002 ProTherm 25786 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 5.81 8.56 1.47 yes Glycine-HCl 3 mM 25.0 Na2SO4 0.80 M CD Urea 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 12070329 10.1110/ps.0205902 2002 ProTherm 25787 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 6.43 10.07 1.57 yes Glycine-HCl 3 mM 25.0 Na2SO4 1.00 M CD Urea 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 12070329 10.1110/ps.0205902 2002 ProTherm 25788 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.44 3.05 2.21 yes Glycine-HCl 3 mM 25.0 NaSCN 0.01 M CD Urea 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 12070329 10.1110/ps.0205902 2002 ProTherm 25789 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.55 2.91 1.87 yes Glycine-HCl 3 mM 25.0 NaSCN 0.05 M CD Urea 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 12070329 10.1110/ps.0205902 2002 ProTherm 25790 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.5 1.85 1.23 yes Glycine-HCl 3 mM 25.0 NaSCN 0.25 M CD Urea 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 12070329 10.1110/ps.0205902 2002 ProTherm 25791 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.38 1.43 1.03 yes Glycine-HCl 3 mM 25.0 NaSCN 0.50 M CD Urea 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 12070329 10.1110/ps.0205902 2002 ProTherm 25792 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.04 1.14 1.1 yes Glycine-HCl 3 mM 25.0 NaSCN 0.75 M CD Urea 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 12070329 10.1110/ps.0205902 2002 ProTherm 25954 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 9.3 Unknown MES 10 mM 25.0 KCL 0.1 M CD Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 12962489 10.1021/bi034499w 2003 ProTherm 26218 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.4 2.57 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26219 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.4 2.54 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26220 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.2 4.77 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 3.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26221 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.9 8.86 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26222 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.2 9.84 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26223 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.7 2.92 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26224 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.7 2.98 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26225 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.5 5.3 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 3.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26226 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.3 9.15 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26227 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.5 9.98 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26228 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.1 3.65 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26229 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.7 6.11 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 3.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26230 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.8 9.3 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26231 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.9 10.2 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26232 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.5 3.93 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26233 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.1 6.48 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 3.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26234 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.2 9.55 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26235 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.3 10.42 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26236 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.1 4.18 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26237 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.5 7.27 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 3.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26238 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.6 2.78 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26239 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.6 2.57 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26240 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.4 5.15 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 3.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26241 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.1 8.8 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26242 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.4 9.89 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26243 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.8 3.03 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26244 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.7 6.14 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 3.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26245 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.6 8.97 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26246 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.7 10.08 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26247 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.3 3.53 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26248 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.8 6.44 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 3.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26249 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.9 9.02 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26250 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.0 10.15 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26251 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.8 3.84 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26252 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.2 6.64 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 3.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26253 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.3 9.29 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26254 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.6 2.88 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26255 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.0 4.84 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 3.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26256 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.0 9.05 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26257 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.3 9.99 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26258 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.8 3.32 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26259 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.8 3.29 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26260 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.1 6.09 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 3.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26261 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.2 9.13 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26262 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.5 10.06 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26263 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.0 3.49 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26264 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.6 6.76 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 3.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26265 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.4 9.19 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26266 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.6 10.2 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26267 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.2 3.63 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26268 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.7 6.97 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 3.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26269 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.6 9.22 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26270 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.8 10.21 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26271 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.0 4.92 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 3.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26272 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.0 8.79 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26273 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.2 9.97 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26274 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.8 3.42 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26275 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.8 3.48 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26276 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.3 5.94 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 3.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26277 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.3 9.11 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26278 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.6 10.12 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26279 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.9 3.57 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26280 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.5 6.52 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 3.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26281 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.6 9.24 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26282 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.7 10.19 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26283 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.2 3.7 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26284 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.6 6.85 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 3.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26285 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.7 9.48 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26286 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.7 10.22 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26287 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.6 2.92 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26288 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.0 5.1 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 3.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26289 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.3 9.9 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26290 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.7 3.08 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26291 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.7 3.06 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26292 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.2 6.0 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 3.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26293 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.3 9.13 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26294 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.5 10.09 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26295 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.9 3.59 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26296 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.5 6.32 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 3.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26297 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.6 9.21 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26298 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.2 3.78 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26299 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.6 6.67 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 3.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26300 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.7 9.37 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 5.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26301 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.8 10.22 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26308 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.1 5.65 2.74 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26309 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.6 3.51 2.26 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26310 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.4 0.87 2.12 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26311 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.8 4.85 2.78 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26312 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.2 2.97 2.54 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26313 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.4 1.05 2.38 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26314 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.5 4.07 2.81 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26315 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.8 2.2 2.76 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26316 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.3 0.79 3.13 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26317 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.7 6.11 2.31 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26318 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.4 6.14 2.55 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26319 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.1 6.09 2.92 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26323 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.8 6.01 1.57 Yes Glycine hydrochloride 0.05 M 25.0 CD Urea 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26324 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.2 5.54 1.73 Yes Glycine hydrochloride 0.05 M 25.0 CD Urea 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26325 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.1 6.36 2.04 Yes Glycine hydrochloride 0.05 M 25.0 CD Urea 3.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26356 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.6 10.59 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26357 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.52 10.51 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26358 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.71 10.66 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26359 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.67 10.1 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26360 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.13 10.71 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26361 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.52 10.56 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26362 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.7 10.49 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26363 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.75 9.93 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26364 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.84 10.66 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26365 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.22 10.55 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26366 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.64 10.48 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26367 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.85 10.56 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26368 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.9 11.17 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26369 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.96 10.6 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26370 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.2 10.66 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26371 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.7 10.4 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26372 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.83 10.67 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26373 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.87 10.3 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26374 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.0 10.63 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26375 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.25 10.74 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26376 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.65 10.5 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26377 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.82 10.53 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26378 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.78 10.05 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26379 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.93 10.63 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26380 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.14 10.61 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26420 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 8.2 Unknown Tris, Gly 25 mM, 192 mM 25.0 NaCl 30 mM Capillary electrophoresis Thermal 8.4 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17234323 10.1016/j.bpc.2006.12.004 2007 ProTherm 26421 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 9.1 Unknown Tris, Gly, sucrose 25 mM, 192 mM, 0.15 M 25.0 NaCl 30 mM Capillary electrophoresis Thermal 8.4 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17234323 10.1016/j.bpc.2006.12.004 2007 ProTherm 26422 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 9.5 Unknown Tris, Gly, sucrose 25 mM, 192 mM, 0.31 M 25.0 NaCl 30 mM Capillary electrophoresis Thermal 8.4 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17234323 10.1016/j.bpc.2006.12.004 2007 ProTherm 26423 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 10.2 Unknown Tris, Gly, sucrose 25 mM, 192 mM, 0.47 M 25.0 NaCl 30 mM Capillary electrophoresis Thermal 8.4 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17234323 10.1016/j.bpc.2006.12.004 2007 ProTherm 26424 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 10.6 Unknown Tris, Gly, sucrose 25 mM, 192 mM, 0.63 M 25.0 NaCl 30 mM Capillary electrophoresis Thermal 8.4 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17234323 10.1016/j.bpc.2006.12.004 2007 ProTherm 26425 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 11.1 Unknown Tris, Gly, sucrose 25 mM, 192 mM, 0.80 M 25.0 NaCl 30 mM Capillary electrophoresis Thermal 8.4 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17234323 10.1016/j.bpc.2006.12.004 2007 ProTherm 26426 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 9.1 Unknown Tris, Gly, fructose 25 mM, 192 mM, 0.29 M 25.0 NaCl 30 mM Capillary electrophoresis Thermal 8.4 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17234323 10.1016/j.bpc.2006.12.004 2007 ProTherm 26427 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 9.5 Unknown Tris, Gly, fructose 25 mM, 192 mM, 0.57 M 25.0 NaCl 30 mM Capillary electrophoresis Thermal 8.4 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17234323 10.1016/j.bpc.2006.12.004 2007 ProTherm 26428 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 10.1 Unknown Tris, Gly, fructose 25 mM, 192 mM, 0.89 M 25.0 NaCl 30 mM Capillary electrophoresis Thermal 8.4 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17234323 10.1016/j.bpc.2006.12.004 2007 ProTherm 26429 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 10.5 Unknown Tris, Gly, fructose 25 mM, 192 mM, 1.21 M 25.0 NaCl 30 mM Capillary electrophoresis Thermal 8.4 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17234323 10.1016/j.bpc.2006.12.004 2007 ProTherm 26430 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 11.2 Unknown Tris, Gly, fructose 25 mM, 192 mM, 1.52 M 25.0 NaCl 30 mM Capillary electrophoresis Thermal 8.4 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 17234323 10.1016/j.bpc.2006.12.004 2007 ProTherm 26491 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.72 Yes Glycine-HCl 0.1 M 25.0 KCl 0.1 M CD GdnHCl 2.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 18201812 10.1016/j.bpc.2007.12.006 2008 ProTherm 26494 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.77 Yes Glycine-HCl 0.1 M 25.0 KCl 0.1 M CD Urea 2.2 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 18201812 10.1016/j.bpc.2007.12.006 2008 ProTherm 26539 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.1 1.99 Yes Sodium phosphate 50 mM 25.0 NaCl 25 mM CD GdnHCl 8.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 19155118 10.1016/j.bpc.2008.12.005 2009 ProTherm 26620 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 5.2 6.1 1.17 yes 2.0 MOPS 30000.0 25.0 Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 24591301 10.1002/pro.2449 2014 ProTherm 26716 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 5.3 6.4 yes 2.0 MOPS 30mM 25.0 Fluorescence Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 21377472 10.1016/j.jmb.2011.02.053 2011 ProTherm 26717 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 6.89 9.5 1.34 yes 2.0 Acetate 30mM 25.0 Fluorescence Urea 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 21377472 10.1016/j.jmb.2011.02.053 2011 ProTherm 26859 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.75 Unknown Tris-HCl 0.1 M 23.0 Fluorescence GdnSCN 8.4 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 11893741 10.1074/jbc.M200040200 2002 ProTherm 26860 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.25 Unknown Tris-HCl 0.1 M 23.0 Fluorescence GdnHCl 8.4 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 11893741 10.1074/jbc.M200040200 2002 ProTherm 26861 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 5.75 Unknown Tris-HCl 0.1 M 23.0 Fluorescence Urea 8.4 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 11893741 10.1074/jbc.M200040200 2002 ProTherm 27112 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.6 2.3 Unknown Mops 50 mM 20.0 CD GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15935376 10.1016/j.jmb.2005.04.074 2005 ProTherm 27113 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.6 1.9 Unknown Mops 50 mM 20.0 Fluorescence GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15935376 10.1016/j.jmb.2005.04.074 2005 ProTherm 27114 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.3 1.8 Unknown Mops 50 mM 20.0 Fluorescence GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15935376 10.1016/j.jmb.2005.04.074 2005 ProTherm 27115 30 130 Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.5 1.9 Unknown Mops 50 mM 20.0 SAXS GdnHCl 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 15935376 10.1016/j.jmb.2005.04.074 2005 ProTherm 15617 7286 130 C28A, C36A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.61 6.75 1.87 Unknown Sodium acetate 50 mM 10.0 Fluorescence GdnHCl 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5.0, 4.0 1YGW, 1RN1, 9RNT 18.361666361490887, 16.771666685740154, 14.02833350499471, 11.440000057220459 in pocket 8756488 10.1021/bi953026p 1996 ProTherm 1067 650 130 N35A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 101.0 -2.1 yes 48.8 MOPS 30 mM Fluorescence Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5.0 1YGW, 1RN1, 9RNT 16.06500005722046, 11.479999899864197 1731929 10.1021/bi00118a013 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7631 650 130 N35A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.71 yes MOPS 30 mM 50.9 Fluorescence Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5.0 1YGW, 1RN1, 9RNT 16.06500005722046, 11.479999899864197 1731929 10.1021/bi00118a013 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 8901 650 130 N35A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.56 0.9 1.28 yes MOPS 30 mM 25.0 Fluorescence Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5.0 1YGW, 1RN1, 9RNT 16.06500005722046, 11.479999899864197 1731929 10.1021/bi00118a013 1992 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, guerios_625_map.csv, potapov_with_uniprot_mapping.csv 1059 642 130 Y37F Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 101.0 -6.0 yes 44.9 MOPS 30 mM Fluorescence Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 12.020833492279053, 8.515833298365274 in pocket 1731929 10.1021/bi00118a013 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7623 642 130 Y37F Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.03 yes MOPS 30 mM 50.9 Fluorescence Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 12.020833492279053, 8.515833298365274 in pocket 1731929 10.1021/bi00118a013 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 8893 642 130 Y37F Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.56 2.11 1.27 yes MOPS 30 mM 25.0 Fluorescence Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 12.020833492279053, 8.515833298365274 in pocket 1731929 10.1021/bi00118a013 1992 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, guerios_625_map.csv, potapov_with_uniprot_mapping.csv 1064 647 130 S38A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 99.0 -3.2 yes 47.7 MOPS 30 mM Fluorescence Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 6.0 1YGW, 1RN1, 9RNT 16.261666774749756, 10.268333435058594 1731929 10.1021/bi00118a013 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7628 647 130 S38A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.08 yes MOPS 30 mM 50.9 Fluorescence Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 6.0 1YGW, 1RN1, 9RNT 16.261666774749756, 10.268333435058594 1731929 10.1021/bi00118a013 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 8898 647 130 S38A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.29 1.23 1.28 yes MOPS 30 mM 25.0 Fluorescence Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 6.0 1YGW, 1RN1, 9RNT 16.261666774749756, 10.268333435058594 1731929 10.1021/bi00118a013 1992 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, guerios_625_map.csv, potapov_with_uniprot_mapping.csv 435 242 130 V42A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) -8.2 yes(0.98) 43.0 MOPS 30 mM CD Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7.0 1YGW, 1RN1, 9RNT 12.612857273646764, 9.095714024135045 11513591 10.1021/bi010565n 2001 ProTherm 445 242 130 V42A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) -7.0 yes(0.98) 44.5 MOPS 30 mM DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7.0 1YGW, 1RN1, 9RNT 12.612857273646764, 9.095714024135045 11513591 10.1021/bi010565n 2001 ProTherm 8737 242 130 V42A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.49 yes(0.98) MOPS 30 mM 25.0 CD Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7.0 1YGW, 1RN1, 9RNT 12.612857273646764, 9.095714024135045 11513591 10.1021/bi010565n 2001 ProTherm SAAFEC_S1262.csv 8748 242 130 V42A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.29 2.19 yes(0.98) MOPS 30 mM 25.0 DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7.0 1YGW, 1RN1, 9RNT 12.612857273646764, 9.095714024135045 11513591 10.1021/bi010565n 2001 ProTherm khan_protherm_data_mapped.csv 12518 242 130 V42A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.12 2.5 3.9 1.23 yes 2.0 MOPS 30mM 25.0 Fluorescence Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7.0 1YGW, 1RN1, 9RNT 12.612857273646764, 9.095714024135045 21377472 10.1016/j.jmb.2011.02.053 2011 ProTherm 436 243 130 V42S Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) -15.6 yes(1.03) 35.6 MOPS 30 mM CD Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7.0 1YGW, 1RN1, 9RNT 12.612857273646764, 9.095714024135045 11513591 10.1021/bi010565n 2001 ProTherm 446 243 130 V42S Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) -14.6 yes(1.03) 36.9 MOPS 30 mM DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7.0 1YGW, 1RN1, 9RNT 12.612857273646764, 9.095714024135045 11513591 10.1021/bi010565n 2001 ProTherm 8738 243 130 V42S Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.66 yes(1.03) MOPS 30 mM 25.0 CD Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7.0 1YGW, 1RN1, 9RNT 12.612857273646764, 9.095714024135045 11513591 10.1021/bi010565n 2001 ProTherm SAAFEC_S1262.csv 8749 243 130 V42S Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.29 4.71 yes(1.03) MOPS 30 mM 25.0 DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7.0 1YGW, 1RN1, 9RNT 12.612857273646764, 9.095714024135045 11513591 10.1021/bi010565n 2001 ProTherm khan_protherm_data_mapped.csv 437 244 130 V42T Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) -11.3 yes(1.04) 39.9 MOPS 30 mM CD Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7.0 1YGW, 1RN1, 9RNT 12.612857273646764, 9.095714024135045 11513591 10.1021/bi010565n 2001 ProTherm 447 244 130 V42T Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) -9.4 yes(1.04) 42.1 MOPS 30 mM DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7.0 1YGW, 1RN1, 9RNT 12.612857273646764, 9.095714024135045 11513591 10.1021/bi010565n 2001 ProTherm 8739 244 130 V42T Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.2 yes(1.04) MOPS 30 mM 25.0 CD Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7.0 1YGW, 1RN1, 9RNT 12.612857273646764, 9.095714024135045 11513591 10.1021/bi010565n 2001 ProTherm SAAFEC_S1262.csv 8750 244 130 V42T Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.29 4.1 yes(1.04) MOPS 30 mM 25.0 DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7.0 1YGW, 1RN1, 9RNT 12.612857273646764, 9.095714024135045 11513591 10.1021/bi010565n 2001 ProTherm khan_protherm_data_mapped.csv 438 245 130 V42C Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) -9.6 yes(0.18) 41.6 MOPS 30 mM CD Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7.0 1YGW, 1RN1, 9RNT 12.612857273646764, 9.095714024135045 11513591 10.1021/bi010565n 2001 ProTherm 448 245 130 V42C Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) -8.9 yes(0.18) 42.6 MOPS 30 mM DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7.0 1YGW, 1RN1, 9RNT 12.612857273646764, 9.095714024135045 11513591 10.1021/bi010565n 2001 ProTherm 8740 245 130 V42C Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 5.3 yes(0.18) MOPS 30 mM 25.0 CD Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7.0 1YGW, 1RN1, 9RNT 12.612857273646764, 9.095714024135045 11513591 10.1021/bi010565n 2001 ProTherm SAAFEC_S1262.csv 8751 245 130 V42C Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.29 4.68 yes(0.18) MOPS 30 mM 25.0 DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7.0 1YGW, 1RN1, 9RNT 12.612857273646764, 9.095714024135045 11513591 10.1021/bi010565n 2001 ProTherm khan_protherm_data_mapped.csv 1065 648 130 S43A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 109.0 1.7 yes 52.6 MOPS 30 mM Fluorescence Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 4.0 1YGW, 1RN1, 9RNT 18.351667245229084, 12.913333257039389 in pocket 1731929 10.1021/bi00118a013 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7629 648 130 S43A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) -0.57 yes MOPS 30 mM 50.9 Fluorescence Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 4.0 1YGW, 1RN1, 9RNT 18.351667245229084, 12.913333257039389 in pocket 1731929 10.1021/bi00118a013 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 8899 648 130 S43A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 5.85 -0.67 1.22 yes MOPS 30 mM 25.0 Fluorescence Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 4.0 1YGW, 1RN1, 9RNT 18.351667245229084, 12.913333257039389 in pocket 1731929 10.1021/bi00118a013 1992 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, guerios_625_map.csv, potapov_with_uniprot_mapping.csv 10963 4664 130 A47G Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 5.5 7.1 1.3 yes Sodium acetate 50 mM 25.0 Fluorescence Urea 7.4 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 4.0 1YGW, 1RN1, 9RNT 16.78600025177002, 11.119999885559082 in pocket 10600109 10.1021/bi9919450 1999 ProTherm 14378 4664 130 A47G Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.23 0.9 1.71 yes glycine 30 mM 0.0 CD Urea 2.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 4.0 1YGW, 1RN1, 9RNT 16.78600025177002, 11.119999885559082 in pocket 9283083 10.1021/bi9707180 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14374 6667 130 A47C Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.33 0.74 1.56 yes glycine 30 mM 0.0 CD Urea 2.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 4.0 1YGW, 1RN1, 9RNT 16.78600025177002, 11.119999885559082 in pocket 9283083 10.1021/bi9707180 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14375 6668 130 A47D Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.98 -0.33 1.59 yes glycine 30 mM 0.0 CD Urea 2.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 4.0 1YGW, 1RN1, 9RNT 16.78600025177002, 11.119999885559082 in pocket 9283083 10.1021/bi9707180 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 14392 6668 130 A47D Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.73 0.71 1.24 yes MOPS 30 mM 0.0 CD Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 4.0 1YGW, 1RN1, 9RNT 16.78600025177002, 11.119999885559082 in pocket 9283083 10.1021/bi9707180 1997 ProTherm capriotti_S1615_map.csv 14376 6669 130 A47E Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.81 -0.05 1.52 yes glycine 30 mM 0.0 CD Urea 2.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 4.0 1YGW, 1RN1, 9RNT 16.78600025177002, 11.119999885559082 in pocket 9283083 10.1021/bi9707180 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 14393 6669 130 A47E Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.75 0.69 1.14 yes MOPS 30 mM 0.0 CD Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 4.0 1YGW, 1RN1, 9RNT 16.78600025177002, 11.119999885559082 in pocket 9283083 10.1021/bi9707180 1997 ProTherm capriotti_S1615_map.csv 14377 6670 130 A47F Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.43 0.57 1.69 yes glycine 30 mM 0.0 CD Urea 2.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 4.0 1YGW, 1RN1, 9RNT 16.78600025177002, 11.119999885559082 in pocket 9283083 10.1021/bi9707180 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14379 6671 130 A47H Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.44 0.56 1.79 yes glycine 30 mM 0.0 CD Urea 2.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 4.0 1YGW, 1RN1, 9RNT 16.78600025177002, 11.119999885559082 in pocket 9283083 10.1021/bi9707180 1997 ProTherm capriotti_S1615_map.csv 14394 6671 130 A47H Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.18 0.17 1.27 yes MOPS 30 mM 0.0 CD Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 4.0 1YGW, 1RN1, 9RNT 16.78600025177002, 11.119999885559082 in pocket 9283083 10.1021/bi9707180 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 14380 6672 130 A47I Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.51 0.44 1.57 yes glycine 30 mM 0.0 CD Urea 2.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 4.0 1YGW, 1RN1, 9RNT 16.78600025177002, 11.119999885559082 in pocket 9283083 10.1021/bi9707180 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14381 6673 130 A47K Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.47 0.51 1.7 yes glycine 30 mM 0.0 CD Urea 2.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 4.0 1YGW, 1RN1, 9RNT 16.78600025177002, 11.119999885559082 in pocket 9283083 10.1021/bi9707180 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14382 6674 130 A47L Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.7 0.13 1.64 yes glycine 30 mM 0.0 CD Urea 2.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 4.0 1YGW, 1RN1, 9RNT 16.78600025177002, 11.119999885559082 in pocket 9283083 10.1021/bi9707180 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14383 6675 130 A47M Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.69 0.15 1.6 yes glycine 30 mM 0.0 CD Urea 2.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 4.0 1YGW, 1RN1, 9RNT 16.78600025177002, 11.119999885559082 in pocket 9283083 10.1021/bi9707180 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14384 6676 130 A47N Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.99 -0.34 1.72 yes glycine 30 mM 0.0 CD Urea 2.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 4.0 1YGW, 1RN1, 9RNT 16.78600025177002, 11.119999885559082 in pocket 9283083 10.1021/bi9707180 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14385 6677 130 A47Q Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.62 0.26 1.6 yes glycine 30 mM 0.0 CD Urea 2.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 4.0 1YGW, 1RN1, 9RNT 16.78600025177002, 11.119999885559082 in pocket 9283083 10.1021/bi9707180 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14395 6677 130 A47Q Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.99 0.4 1.12 yes MOPS 30 mM 0.0 CD Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 4.0 1YGW, 1RN1, 9RNT 16.78600025177002, 11.119999885559082 in pocket 9283083 10.1021/bi9707180 1997 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 14386 6678 130 A47R Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.53 0.41 1.65 yes glycine 30 mM 0.0 CD Urea 2.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 4.0 1YGW, 1RN1, 9RNT 16.78600025177002, 11.119999885559082 in pocket 9283083 10.1021/bi9707180 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14387 6679 130 A47S Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.48 0.49 1.67 yes glycine 30 mM 0.0 CD Urea 2.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 4.0 1YGW, 1RN1, 9RNT 16.78600025177002, 11.119999885559082 in pocket 9283083 10.1021/bi9707180 1997 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 14396 6679 130 A47S Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.99 0.4 1.22 yes MOPS 30 mM 0.0 CD Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 4.0 1YGW, 1RN1, 9RNT 16.78600025177002, 11.119999885559082 in pocket 9283083 10.1021/bi9707180 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14388 6680 130 A47T Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.43 0.57 1.6 yes glycine 30 mM 0.0 CD Urea 2.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 4.0 1YGW, 1RN1, 9RNT 16.78600025177002, 11.119999885559082 in pocket 9283083 10.1021/bi9707180 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14389 6681 130 A47V Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.38 0.66 1.77 yes glycine 30 mM 0.0 CD Urea 2.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 4.0 1YGW, 1RN1, 9RNT 16.78600025177002, 11.119999885559082 in pocket 9283083 10.1021/bi9707180 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14390 6682 130 A47W Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.6 0.3 1.56 yes glycine 30 mM 0.0 CD Urea 2.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 4.0 1YGW, 1RN1, 9RNT 16.78600025177002, 11.119999885559082 in pocket 9283083 10.1021/bi9707180 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14391 6683 130 A47Y Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.54 0.39 1.69 yes glycine 30 mM 0.0 CD Urea 2.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 4.0 1YGW, 1RN1, 9RNT 16.78600025177002, 11.119999885559082 in pocket 9283083 10.1021/bi9707180 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 15377 7139 130 A47G, G49A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.7 6.0 1.37 yes Sodium acetate 50 mM 25.0 Fluorescence Urea 7.4 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 4.0, 9.0 1YGW, 1RN1, 9RNT 16.78600025177002, 15.960000276565552, 11.119999885559082, 7.617500185966492 in pocket 10600109 10.1021/bi9919450 1999 ProTherm 10964 4665 130 G49A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 5.4 7.0 1.26 yes Sodium acetate 50 mM 25.0 Fluorescence Urea 7.4 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 15.960000276565552, 7.617500185966492 10600109 10.1021/bi9919450 1999 ProTherm 30 30 130 Y50W Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 106.12 1.6 yes 58.8 sodium acetate, calcium acetate 20 mM, 2 mM Mops 50 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 6.0 1YGW, 1RN1, 9RNT 14.984166622161865, 8.805833419164022 in pocket 8125111 10.1111/j.1432-1033.1994.tb18652.x 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8549 30 130 Y50W Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.98 -1.24 yes sodium acetate, calcium acetate 20 mM, 2 mM 25.0 Mops 50 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 6.0 1YGW, 1RN1, 9RNT 14.984166622161865, 8.805833419164022 in pocket 8125111 10.1111/j.1432-1033.1994.tb18652.x 1994 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, potapov_with_uniprot_mapping.csv 8555 30 130 Y50W Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.98 9.03 yes sodium acetate, calcium acetate 20 mM, 2 mM 25.0 Mops 50 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 6.0 1YGW, 1RN1, 9RNT 14.984166622161865, 8.805833419164022 in pocket 8125111 10.1111/j.1432-1033.1994.tb18652.x 1994 ProTherm 14433 6692 130 Y50W, W85Y Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 100.62 -0.6 yes 56.6 sodium acetate, calcium acetate 20 mM, 2 mM Mops 50 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 6.0, 8.0 1YGW, 1RN1, 9RNT 14.984166622161865, 13.562857014792305, 8.805833419164022, 7.767142840794155 in pocket 8125111 10.1111/j.1432-1033.1994.tb18652.x 1994 ProTherm 15147 6692 130 Y50W, W85Y Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.98 -0.29 yes sodium acetate, calcium acetate 20 mM, 2 mM 25.0 Mops 50 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 6.0, 8.0 1YGW, 1RN1, 9RNT 14.984166622161865, 13.562857014792305, 8.805833419164022, 7.767142840794155 in pocket 8125111 10.1111/j.1432-1033.1994.tb18652.x 1994 ProTherm 15152 6692 130 Y50W, W85Y Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.98 8.1 yes sodium acetate, calcium acetate 20 mM, 2 mM 25.0 Mops 50 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 6.0, 8.0 1YGW, 1RN1, 9RNT 14.984166622161865, 13.562857014792305, 8.805833419164022, 7.767142840794155 in pocket 8125111 10.1111/j.1432-1033.1994.tb18652.x 1994 ProTherm 1057 640 130 Q51K Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 107.0 3.4 Unknown 51.7 MOPS 30 mM Fluorescence Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 3.0 1YGW, 1RN1, 9RNT 28.753333303663467, 15.534444279140896 in pocket 2663837 1989 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3013 640 130 Q51K Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.14 121.5 114.8 2.4 yes 61.2 Sodium borate-NaOH 10 mM NaCl 80 mM DSC Thermal 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 3.0 1YGW, 1RN1, 9RNT 28.753333303663467, 15.534444279140896 in pocket 8136367 10.1021/bi00177a023 1994 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3014 640 130 Q51K Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.99 112.4 110.5 2.8 yes 56.9 Sodium borate-NaOH 10 mM NaCl 80 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 3.0 1YGW, 1RN1, 9RNT 28.753333303663467, 15.534444279140896 in pocket 8136367 10.1021/bi00177a023 1994 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3015 640 130 Q51K Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.19 109.3 108.6 2.9 yes 54.0 Sodium borate-NaOH 10 mM NaCl 80 mM DSC Thermal 6.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 3.0 1YGW, 1RN1, 9RNT 28.753333303663467, 15.534444279140896 in pocket 8136367 10.1021/bi00177a023 1994 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3016 640 130 Q51K Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.43 106.5 98.6 3.3 yes 52.1 Sodium borate-NaOH 10 mM NaCl 80 mM DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 3.0 1YGW, 1RN1, 9RNT 28.753333303663467, 15.534444279140896 in pocket 8136367 10.1021/bi00177a023 1994 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3017 640 130 Q51K Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.15 97.6 102.2 3.2 yes 46.6 Sodium borate-NaOH 10 mM NaCl 80 mM DSC Thermal 8.6 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 3.0 1YGW, 1RN1, 9RNT 28.753333303663467, 15.534444279140896 in pocket 8136367 10.1021/bi00177a023 1994 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, M47andM8_S2760.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, M47andM8_S1810.csv, PON-TStab_dataset.csv, iPTREE-STAB_S1859.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3018 640 130 Q51K Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.38 94.0 105.0 3.3 yes 44.0 Sodium borate-NaOH 10 mM NaCl 80 mM DSC Thermal 9.7 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 3.0 1YGW, 1RN1, 9RNT 28.753333303663467, 15.534444279140896 in pocket 8136367 10.1021/bi00177a023 1994 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, PON-TStab_dataset.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7759 640 130 Q51K Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) -0.93 Unknown MOPS 30 mM 48.6 Fluorescence Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 3.0 1YGW, 1RN1, 9RNT 28.753333303663467, 15.534444279140896 in pocket 2663837 1989 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, potapov_with_uniprot_mapping.csv 8891 640 130 Q51K Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 5.3 -0.77 6.39 1.21 Unknown MOPS 30 mM 25.0 Fluorescence Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 3.0 1YGW, 1RN1, 9RNT 28.753333303663467, 15.534444279140896 in pocket 2663837 1989 ProTherm SAAFEC_S1262.csv 14596 6799 130 Q51K, E84A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 93.0 -0.5 Unknown 48.8 MOPS 30 mM Fluorescence Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 Proton acceptor 3.0, 9.0 1YGW, 1RN1, 9RNT 28.753333303663467, 19.051111115349663, 15.534444279140896, 11.863333172268337 in tunnel in pocket 2663837 1989 ProTherm 15060 6799 130 Q51K, E84A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) -0.06 Unknown MOPS 30 mM 48.6 Fluorescence Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 Proton acceptor 3.0, 9.0 1YGW, 1RN1, 9RNT 28.753333303663467, 19.051111115349663, 15.534444279140896, 11.863333172268337 in tunnel in pocket 2663837 1989 ProTherm 15167 6799 130 Q51K, E84A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.58 -0.67 6.29 1.36 Unknown MOPS 30 mM 25.0 Fluorescence Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 Proton acceptor 3.0, 9.0 1YGW, 1RN1, 9RNT 28.753333303663467, 19.051111115349663, 15.534444279140896, 11.863333172268337 in tunnel in pocket 2663837 1989 ProTherm 1068 651 130 N62A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 111.0 0.0 yes 50.9 MOPS 30 mM Fluorescence Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 6.0 1YGW, 1RN1, 9RNT 31.86875033378601, 22.698749661445618 in tunnel 1731929 10.1021/bi00118a013 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7632 651 130 N62A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.0 yes MOPS 30 mM 50.9 Fluorescence Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 6.0 1YGW, 1RN1, 9RNT 31.86875033378601, 22.698749661445618 in tunnel 1731929 10.1021/bi00118a013 1992 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv 8902 651 130 N62A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 5.31 -0.03 1.31 yes MOPS 30 mM 25.0 Fluorescence Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 6.0 1YGW, 1RN1, 9RNT 31.86875033378601, 22.698749661445618 in tunnel 1731929 10.1021/bi00118a013 1992 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 10300 4346 130 P65A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.71 5.12 4.88 2.63 yes Sodium acetate 0.1 M 25.0 Fluorescence GdnHCl 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 13.341428620474678, 9.507142884390694 in pocket 8515459 10.1006/jmbi.1993.1336 1993 ProTherm 13999 4346 130 P65A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.21 4.95 4.88 2.22 yes Sodium acetate 0.1 M 10.0 Fluorescence GdnHCl 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 13.341428620474678, 9.507142884390694 in pocket 8515459 10.1006/jmbi.1993.1336 1993 ProTherm 14000 4346 130 P65A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.43 4.33 4.11 2.87 yes Tris 0.1 M 10.0 Fluorescence GdnHCl 8.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 13.341428620474678, 9.507142884390694 in pocket 8515459 10.1006/jmbi.1993.1336 1993 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv 33 33 130 H66T Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 100.14 -0.5 yes 56.7 sodium acetate, calcium acetate 20 mM, 2 mM Mops 50 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 active site 9.0 1YGW, 1RN1, 9RNT 14.695999908447266, 12.854000091552734 in tunnel in pocket 8125111 10.1111/j.1432-1033.1994.tb18652.x 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8552 33 130 H66T Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.98 0.26 yes sodium acetate, calcium acetate 20 mM, 2 mM 25.0 Mops 50 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 active site 9.0 1YGW, 1RN1, 9RNT 14.695999908447266, 12.854000091552734 in tunnel in pocket 8125111 10.1111/j.1432-1033.1994.tb18652.x 1994 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8558 33 130 H66T Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.98 8.08 yes sodium acetate, calcium acetate 20 mM, 2 mM 25.0 Mops 50 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 active site 9.0 1YGW, 1RN1, 9RNT 14.695999908447266, 12.854000091552734 in tunnel in pocket 8125111 10.1111/j.1432-1033.1994.tb18652.x 1994 ProTherm 14436 6695 130 H66T, W85Y Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 92.5 -3.3 yes 53.9 sodium acetate, calcium acetate 20 mM, 2 mM Mops 50 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 active site 9.0, 8.0 1YGW, 1RN1, 9RNT 14.695999908447266, 13.562857014792305, 12.854000091552734, 7.767142840794155 in tunnel in pocket 8125111 10.1111/j.1432-1033.1994.tb18652.x 1994 ProTherm 15150 6695 130 H66T, W85Y Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.98 0.93 yes sodium acetate, calcium acetate 20 mM, 2 mM 25.0 Mops 50 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 active site 9.0, 8.0 1YGW, 1RN1, 9RNT 14.695999908447266, 13.562857014792305, 12.854000091552734, 7.767142840794155 in tunnel in pocket 8125111 10.1111/j.1432-1033.1994.tb18652.x 1994 ProTherm 15155 6695 130 H66T, W85Y Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.98 6.88 yes sodium acetate, calcium acetate 20 mM, 2 mM 25.0 Mops 50 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 active site 9.0, 8.0 1YGW, 1RN1, 9RNT 14.695999908447266, 13.562857014792305, 12.854000091552734, 7.767142840794155 in tunnel in pocket 8125111 10.1111/j.1432-1033.1994.tb18652.x 1994 ProTherm 31 31 130 Y68W Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 96.08 -0.6 yes 56.6 sodium acetate, calcium acetate 20 mM, 2 mM Mops 50 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0 1YGW, 1RN1, 9RNT 17.37499992052714, 12.515833377838135 in tunnel in pocket 8125111 10.1111/j.1432-1033.1994.tb18652.x 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8550 31 130 Y68W Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.98 0.14 yes sodium acetate, calcium acetate 20 mM, 2 mM 25.0 Mops 50 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0 1YGW, 1RN1, 9RNT 17.37499992052714, 12.515833377838135 in tunnel in pocket 8125111 10.1111/j.1432-1033.1994.tb18652.x 1994 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8556 31 130 Y68W Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.98 7.67 yes sodium acetate, calcium acetate 20 mM, 2 mM 25.0 Mops 50 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0 1YGW, 1RN1, 9RNT 17.37499992052714, 12.515833377838135 in tunnel in pocket 8125111 10.1111/j.1432-1033.1994.tb18652.x 1994 ProTherm 1060 643 130 Y68F Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 106.0 3.4 yes 54.3 MOPS 30 mM Fluorescence Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0 1YGW, 1RN1, 9RNT 17.37499992052714, 12.515833377838135 in tunnel in pocket 1731929 10.1021/bi00118a013 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7624 643 130 Y68F Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) -1.15 yes MOPS 30 mM 50.9 Fluorescence Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0 1YGW, 1RN1, 9RNT 17.37499992052714, 12.515833377838135 in tunnel in pocket 1731929 10.1021/bi00118a013 1992 ProTherm capriotti_S1615_map.csv 8894 643 130 Y68F Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 6.24 -1.14 1.17 yes MOPS 30 mM 25.0 Fluorescence Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0 1YGW, 1RN1, 9RNT 17.37499992052714, 12.515833377838135 in tunnel in pocket 1731929 10.1021/bi00118a013 1992 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14434 6693 130 Y68W, W85Y Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 91.78 -3.5 yes 53.7 sodium acetate, calcium acetate 20 mM, 2 mM Mops 50 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0, 8.0 1YGW, 1RN1, 9RNT 17.37499992052714, 13.562857014792305, 12.515833377838135, 7.767142840794155 in tunnel in pocket 8125111 10.1111/j.1432-1033.1994.tb18652.x 1994 ProTherm 15148 6693 130 Y68W, W85Y Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.98 1.03 yes sodium acetate, calcium acetate 20 mM, 2 mM 25.0 Mops 50 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0, 8.0 1YGW, 1RN1, 9RNT 17.37499992052714, 13.562857014792305, 12.515833377838135, 7.767142840794155 in tunnel in pocket 8125111 10.1111/j.1432-1033.1994.tb18652.x 1994 ProTherm 15153 6693 130 Y68W, W85Y Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.98 6.76 yes sodium acetate, calcium acetate 20 mM, 2 mM 25.0 Mops 50 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0, 8.0 1YGW, 1RN1, 9RNT 17.37499992052714, 13.562857014792305, 12.515833377838135, 7.767142840794155 in tunnel in pocket 8125111 10.1111/j.1432-1033.1994.tb18652.x 1994 ProTherm 1069 652 130 N70A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 91.0 -5.5 yes 45.4 MOPS 30 mM Fluorescence Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0 1YGW, 1RN1, 9RNT 19.06374979019165, 10.283750057220459 in tunnel in pocket 1731929 10.1021/bi00118a013 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 1098 652 130 N70A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 86.8 -5.2 Yes 2.0 45.6 MOPS 30 mM CD Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0 1YGW, 1RN1, 9RNT 19.06374979019165, 10.283750057220459 in tunnel in pocket 9819211 10.1021/bi9815243 1998 ProTherm HotMuSiC_S1626.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3309 652 130 N70A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 86.8 -5.2 yes (>95%) 45.6 MOPS 30 mM CD Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0 1YGW, 1RN1, 9RNT 19.06374979019165, 10.283750057220459 in tunnel in pocket 9819211 10.1021/bi9815243 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7633 652 130 N70A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.86 yes MOPS 30 mM 50.9 Fluorescence Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0 1YGW, 1RN1, 9RNT 19.06374979019165, 10.283750057220459 in tunnel in pocket 1731929 10.1021/bi00118a013 1992 ProTherm capriotti_S1615_map.csv 7637 652 130 N70A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.6 yes (>95%) MOPS 30 mM 50.8 CD Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0 1YGW, 1RN1, 9RNT 19.06374979019165, 10.283750057220459 in tunnel in pocket 9819211 10.1021/bi9815243 1998 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 8903 652 130 N70A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.59 2.08 1.3 yes MOPS 30 mM 25.0 Fluorescence Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0 1YGW, 1RN1, 9RNT 19.06374979019165, 10.283750057220459 in tunnel in pocket 1731929 10.1021/bi00118a013 1992 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv 8914 652 130 N70A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.51 2.0 4.12 1.17 Yes 2.0 MOPS 30 mM 25.0 Fluorescence Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0 1YGW, 1RN1, 9RNT 19.06374979019165, 10.283750057220459 in tunnel in pocket 9819211 10.1021/bi9815243 1998 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 10697 652 130 N70A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.51 2.0 4.12 1.17 yes (>95%) MOPS 30 mM 25.0 CD Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0 1YGW, 1RN1, 9RNT 19.06374979019165, 10.283750057220459 in tunnel in pocket 9819211 10.1021/bi9815243 1998 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 1096 668 130 N70D Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 84.2 -5.5 Yes 2.0 45.3 MOPS 30 mM CD Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0 1YGW, 1RN1, 9RNT 19.06374979019165, 10.283750057220459 in tunnel in pocket 9819211 10.1021/bi9815243 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3307 668 130 N70D Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 84.2 -5.5 yes (>95%) 45.3 MOPS 30 mM CD Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0 1YGW, 1RN1, 9RNT 19.06374979019165, 10.283750057220459 in tunnel in pocket 9819211 10.1021/bi9815243 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7635 668 130 N70D Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.6 yes (>95%) MOPS 30 mM 50.8 CD Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0 1YGW, 1RN1, 9RNT 19.06374979019165, 10.283750057220459 in tunnel in pocket 9819211 10.1021/bi9815243 1998 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 8912 668 130 N70D Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.54 2.0 4.43 1.25 Yes 2.0 MOPS 30 mM 25.0 Fluorescence Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0 1YGW, 1RN1, 9RNT 19.06374979019165, 10.283750057220459 in tunnel in pocket 9819211 10.1021/bi9815243 1998 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv 8915 668 130 N70D Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.45 5.71 1.66 Yes 2.0 glycine 30 mM 25.0 Fluorescence Urea 2.7 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0 1YGW, 1RN1, 9RNT 19.06374979019165, 10.283750057220459 in tunnel in pocket 9819211 10.1021/bi9815243 1998 ProTherm 10695 668 130 N70D Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.54 2.0 4.43 1.25 yes (>95%) MOPS 30 mM 25.0 CD Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0 1YGW, 1RN1, 9RNT 19.06374979019165, 10.283750057220459 in tunnel in pocket 9819211 10.1021/bi9815243 1998 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv 10698 668 130 N70D Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.45 0.5 5.71 1.66 yes (>95%) glycine 30 mM 25.0 CD Urea 2.7 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0 1YGW, 1RN1, 9RNT 19.06374979019165, 10.283750057220459 in tunnel in pocket 9819211 10.1021/bi9815243 1998 ProTherm 1097 669 130 N70S Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 89.6 -5.0 Yes 2.0 45.8 MOPS 30 mM CD Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0 1YGW, 1RN1, 9RNT 19.06374979019165, 10.283750057220459 in tunnel in pocket 9819211 10.1021/bi9815243 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3308 669 130 N70S Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 89.6 -5.0 yes (>95%) 45.8 MOPS 30 mM CD Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0 1YGW, 1RN1, 9RNT 19.06374979019165, 10.283750057220459 in tunnel in pocket 9819211 10.1021/bi9815243 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7636 669 130 N70S Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.5 yes (>95%) MOPS 30 mM 50.8 CD Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0 1YGW, 1RN1, 9RNT 19.06374979019165, 10.283750057220459 in tunnel in pocket 9819211 10.1021/bi9815243 1998 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8913 669 130 N70S Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.6 1.9 4.39 1.22 Yes 2.0 MOPS 30 mM 25.0 Fluorescence Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0 1YGW, 1RN1, 9RNT 19.06374979019165, 10.283750057220459 in tunnel in pocket 9819211 10.1021/bi9815243 1998 ProTherm SAAFEC_S1262.csv 10696 669 130 N70S Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.6 1.9 4.39 1.22 yes (>95%) MOPS 30 mM 25.0 CD Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0 1YGW, 1RN1, 9RNT 19.06374979019165, 10.283750057220459 in tunnel in pocket 9819211 10.1021/bi9815243 1998 ProTherm SAAFEC_S1262.csv 32 32 130 Y71W Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 106.84 -1.3 yes 55.9 sodium acetate, calcium acetate 20 mM, 2 mM Mops 50 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5.0 1YGW, 1RN1, 9RNT 30.34090891751376, 17.1349999109904 in tunnel in pocket 8125111 10.1111/j.1432-1033.1994.tb18652.x 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 2917 32 130 Y71W Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) -1.6 yes 56.0 Sodium cacodylate 10 mM Absorbance Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5.0 1YGW, 1RN1, 9RNT 30.34090891751376, 17.1349999109904 in tunnel in pocket 8075073 10.1021/bi00201a021 1994 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8551 32 130 Y71W Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.98 -0.74 yes sodium acetate, calcium acetate 20 mM, 2 mM 25.0 Mops 50 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5.0 1YGW, 1RN1, 9RNT 30.34090891751376, 17.1349999109904 in tunnel in pocket 8125111 10.1111/j.1432-1033.1994.tb18652.x 1994 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, khan_protherm_data_mapped.csv 8557 32 130 Y71W Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.98 8.56 yes sodium acetate, calcium acetate 20 mM, 2 mM 25.0 Mops 50 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5.0 1YGW, 1RN1, 9RNT 30.34090891751376, 17.1349999109904 in tunnel in pocket 8125111 10.1111/j.1432-1033.1994.tb18652.x 1994 ProTherm 14435 6694 130 Y71W, W85Y Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 95.12 -4.4 yes 52.8 sodium acetate, calcium acetate 20 mM, 2 mM Mops 50 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5.0, 8.0 1YGW, 1RN1, 9RNT 30.34090891751376, 13.562857014792305, 17.1349999109904, 7.767142840794155 in tunnel in pocket 8125111 10.1111/j.1432-1033.1994.tb18652.x 1994 ProTherm 14671 6694 130 Y71W, W85Y Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) -4.5 yes 53.1 Sodium cacodylate 10 mM Absorbance Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5.0, 8.0 1YGW, 1RN1, 9RNT 30.34090891751376, 13.562857014792305, 17.1349999109904, 7.767142840794155 in tunnel in pocket 8075073 10.1021/bi00201a021 1994 ProTherm 15149 6694 130 Y71W, W85Y Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.98 0.91 yes sodium acetate, calcium acetate 20 mM, 2 mM 25.0 Mops 50 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5.0, 8.0 1YGW, 1RN1, 9RNT 30.34090891751376, 13.562857014792305, 17.1349999109904, 7.767142840794155 in tunnel in pocket 8125111 10.1111/j.1432-1033.1994.tb18652.x 1994 ProTherm 15154 6694 130 Y71W, W85Y Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.98 6.91 yes sodium acetate, calcium acetate 20 mM, 2 mM 25.0 Mops 50 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5.0, 8.0 1YGW, 1RN1, 9RNT 30.34090891751376, 13.562857014792305, 17.1349999109904, 7.767142840794155 in tunnel in pocket 8125111 10.1111/j.1432-1033.1994.tb18652.x 1994 ProTherm 11047 4687 130 D75A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 5.67 0.5 1.21 Unknown MOPS 30 mM 25.0 CD Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 3.0 1YGW, 1RN1, 9RNT 20.084999918937683, 25.332499861717224 in pocket 10493585 10.1110/ps.8.9.1843 1999 ProTherm SAAFEC_S1262.csv 11048 4687 130 D75A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.42 -0.4 1.69 Unknown glycine 30 mM 25.0 CD Urea 2.5 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 3.0 1YGW, 1RN1, 9RNT 20.084999918937683, 25.332499861717224 in pocket 10493585 10.1110/ps.8.9.1843 1999 ProTherm guerios_625_map.csv 11148 4733 130 D75H Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) -1.1 Unknown MOPS 30 mM 25.0 CD Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 3.0 1YGW, 1RN1, 9RNT 20.084999918937683, 25.332499861717224 in pocket 10933506 10.1110/ps.9.7.1395 2000 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 15606 7281 130 S80G, P81N Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.44 Unknown Tris-HCl 0.1 M 15.0 NaCl 2.5 M CD Urea 8.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 6.0, 5.0 1YGW, 1RN1, 9RNT 26.083333015441895, 24.64999989100865, 21.9350004196167, 14.9242856161935 7981223 10.1021/bi00252a029 1994 ProTherm 15610 7281 130 S80G, P81N Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 5.98 Unknown Tris-HCl 0.1 M 15.0 NaCl 2.8 M Absorbance Urea 8.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 6.0, 5.0 1YGW, 1RN1, 9RNT 26.083333015441895, 24.64999989100865, 21.9350004196167, 14.9242856161935 8014991 10.1006/jmbi.1994.1408 1994 ProTherm 15612 7281 130 S80G, P81N Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 11.21 2.8 Unknown Na acetate 0.1 M 10.0 CD GdnHCl 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 6.0, 5.0 1YGW, 1RN1, 9RNT 26.083333015441895, 24.64999989100865, 21.9350004196167, 14.9242856161935 1304394 10.1002/pro.5560010910 1992 ProTherm 1061 644 130 Y82F Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 99.0 -2.1 yes 48.8 MOPS 30 mM Fluorescence Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5.0 1YGW, 1RN1, 9RNT 19.30416663487752, 13.486666520436605 1731929 10.1021/bi00118a013 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7625 644 130 Y82F Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.71 yes MOPS 30 mM 50.9 Fluorescence Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5.0 1YGW, 1RN1, 9RNT 19.30416663487752, 13.486666520436605 1731929 10.1021/bi00118a013 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 8895 644 130 Y82F Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.65 0.78 1.26 yes MOPS 30 mM 25.0 Fluorescence Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5.0 1YGW, 1RN1, 9RNT 19.30416663487752, 13.486666520436605 1731929 10.1021/bi00118a013 1992 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, guerios_625_map.csv, potapov_with_uniprot_mapping.csv 1062 645 130 Y83F Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 107.0 -1.3 yes 49.6 MOPS 30 mM Fluorescence Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 4.0 1YGW, 1RN1, 9RNT 17.988333384195965, 11.56249996026357 in pocket 1731929 10.1021/bi00118a013 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7626 645 130 Y83F Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.44 yes MOPS 30 mM 50.9 Fluorescence Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 4.0 1YGW, 1RN1, 9RNT 17.988333384195965, 11.56249996026357 in pocket 1731929 10.1021/bi00118a013 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 8896 645 130 Y83F Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.88 0.5 1.29 yes MOPS 30 mM 25.0 Fluorescence Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 4.0 1YGW, 1RN1, 9RNT 17.988333384195965, 11.56249996026357 in pocket 1731929 10.1021/bi00118a013 1992 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, guerios_625_map.csv, potapov_with_uniprot_mapping.csv 1058 641 130 E84A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 86.0 -2.3 Unknown 46.0 MOPS 30 mM Fluorescence Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 Proton acceptor 9.0 1YGW, 1RN1, 9RNT 19.051111115349663, 11.863333172268337 in tunnel in pocket 2663837 1989 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7760 641 130 E84A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.78 Unknown MOPS 30 mM 48.6 Fluorescence Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 Proton acceptor 9.0 1YGW, 1RN1, 9RNT 19.051111115349663, 11.863333172268337 in tunnel in pocket 2663837 1989 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, khan_protherm_data_mapped.csv 8892 641 130 E84A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.92 0.9 4.72 1.2 Unknown MOPS 30 mM 25.0 Fluorescence Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 Proton acceptor 9.0 1YGW, 1RN1, 9RNT 19.051111115349663, 11.863333172268337 in tunnel in pocket 2663837 1989 ProTherm 10521 641 130 E84A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 5.67 0.64 7.6 1.34 Unknown MES 30 mM 25.0 NaCl 0.2 M Fluorescence Urea 6.01 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 Proton acceptor 9.0 1YGW, 1RN1, 9RNT 19.051111115349663, 11.863333172268337 in tunnel in pocket 1980207 10.1021/bi00485a005 1990 ProTherm potapov_with_uniprot_mapping.csv 10522 641 130 E84A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.89 -0.71 6.63 1.36 Unknown HEPPSO 30 mM 25.0 NaCl 0.2 mM Fluorescence Urea 8.01 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 Proton acceptor 9.0 1YGW, 1RN1, 9RNT 19.051111115349663, 11.863333172268337 in tunnel in pocket 1980207 10.1021/bi00485a005 1990 ProTherm guerios_625_map.csv 29 29 130 W85Y Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 91.78 -2.9 yes 54.3 sodium acetate, calcium acetate 20 mM, 2 mM Mops 50 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0 1YGW, 1RN1, 9RNT 13.562857014792305, 7.767142840794155 in pocket 8125111 10.1111/j.1432-1033.1994.tb18652.x 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 2916 29 130 W85Y Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) -4.2 yes 53.4 Sodium cacodylate 10 mM Absorbance Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0 1YGW, 1RN1, 9RNT 13.562857014792305, 7.767142840794155 in pocket 8075073 10.1021/bi00201a021 1994 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3632 29 130 W85Y Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 20.0 yes 65.0 Sodium cacodylate-D2O 100 mM Absorbance Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0 1YGW, 1RN1, 9RNT 13.562857014792305, 7.767142840794155 in pocket 10024018 10.1002/(sici)1097-0134(19990215)34:3<303::aid-prot4>3.0.co;2-h 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 8548 29 130 W85Y Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.98 0.93 yes sodium acetate, calcium acetate 20 mM, 2 mM 25.0 Mops 50 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0 1YGW, 1RN1, 9RNT 13.562857014792305, 7.767142840794155 in pocket 8125111 10.1111/j.1432-1033.1994.tb18652.x 1994 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8554 29 130 W85Y Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.98 6.88 yes sodium acetate, calcium acetate 20 mM, 2 mM 25.0 Mops 50 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0 1YGW, 1RN1, 9RNT 13.562857014792305, 7.767142840794155 in pocket 8125111 10.1111/j.1432-1033.1994.tb18652.x 1994 ProTherm 14437 6696 130 W85Y, H118A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 87.0 -4.0 yes 53.2 sodium acetate, calcium acetate 20 mM, 2 mM Mops 50 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 Proton donor 8.0, 9.0 1YGW, 1RN1, 9RNT 13.562857014792305, 13.583999919891358, 7.767142840794155, 11.221999979019165 in tunnel in pocket 8125111 10.1111/j.1432-1033.1994.tb18652.x 1994 ProTherm 15151 6696 130 W85Y, H118A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.98 1.53 yes sodium acetate, calcium acetate 20 mM, 2 mM 25.0 Mops 50 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 Proton donor 8.0, 9.0 1YGW, 1RN1, 9RNT 13.562857014792305, 13.583999919891358, 7.767142840794155, 11.221999979019165 in tunnel in pocket 8125111 10.1111/j.1432-1033.1994.tb18652.x 1994 ProTherm 15156 6696 130 W85Y, H118A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.98 6.26 yes sodium acetate, calcium acetate 20 mM, 2 mM 25.0 Mops 50 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 Proton donor 8.0, 9.0 1YGW, 1RN1, 9RNT 13.562857014792305, 13.583999919891358, 7.767142840794155, 11.221999979019165 in tunnel in pocket 8125111 10.1111/j.1432-1033.1994.tb18652.x 1994 ProTherm 12519 5801 130 I87V Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.64 1.8 4.6 1.23 yes 2.0 MOPS 30mM 25.0 Fluorescence Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0 1YGW, 1RN1, 9RNT 12.756250143051147, 7.943750023841858 in pocket 21377472 10.1016/j.jmb.2011.02.053 2011 ProTherm 1066 649 130 S90A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 104.0 -4.6 yes 46.3 MOPS 30 mM Fluorescence Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 6.0 1YGW, 1RN1, 9RNT 25.21666653951009, 12.62833340962728 1731929 10.1021/bi00118a013 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7630 649 130 S90A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.56 yes MOPS 30 mM 50.9 Fluorescence Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 6.0 1YGW, 1RN1, 9RNT 25.21666653951009, 12.62833340962728 1731929 10.1021/bi00118a013 1992 ProTherm capriotti_S1615_map.csv 8900 649 130 S90A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.11 1.44 1.38 yes MOPS 30 mM 25.0 Fluorescence Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 6.0 1YGW, 1RN1, 9RNT 25.21666653951009, 12.62833340962728 1731929 10.1021/bi00118a013 1992 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1063 646 130 Y94F Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 89.0 -4.0 yes 46.9 MOPS 30 mM Fluorescence Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 17.174999952316284, 9.024999936421713 in pocket 1731929 10.1021/bi00118a013 1992 ProTherm AUTOMUTE_S1749.csv, HotMuSiC_S1626.csv, Saraboji_S1791.csv 7627 646 130 Y94F Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.35 yes MOPS 30 mM 50.9 Fluorescence Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 17.174999952316284, 9.024999936421713 in pocket 1731929 10.1021/bi00118a013 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 8897 646 130 Y94F Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.17 1.36 1.32 yes MOPS 30 mM 25.0 Fluorescence Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 17.174999952316284, 9.024999936421713 in pocket 1731929 10.1021/bi00118a013 1992 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, guerios_625_map.csv, potapov_with_uniprot_mapping.csv 11282 4803 130 P99V Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.88 -2.13 2.84 yes Sodium acetate 0.1 M 25.0 Fluorescence GdnHCl 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 18.687142508370535, 8.661428792136055 8917450 10.1111/j.1432-1033.1996.00516.x 1996 ProTherm 11283 4803 130 P99V Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.66 -2.01 2.7 yes PIPES 0.1 M 25.0 Fluorescence GdnHCl 8.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 18.687142508370535, 8.661428792136055 8917450 10.1111/j.1432-1033.1996.00516.x 1996 ProTherm SAAFEC_S1262.csv 14097 4803 130 P99V Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.43 -1.53 3.01 yes Sodium acetate 0.1 M 10.0 Fluorescence GdnHCl 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 18.687142508370535, 8.661428792136055 8917450 10.1111/j.1432-1033.1996.00516.x 1996 ProTherm 14098 4803 130 P99V Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.44 -2.44 3.18 yes PIPES 0.1 M 10.0 Fluorescence GdnHCl 8.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 18.687142508370535, 8.661428792136055 8917450 10.1111/j.1432-1033.1996.00516.x 1996 ProTherm 3633 1885 130 D102N Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 76.0 -13.8 yes 37.0 MOPS 30 mM DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 12.204999923706055, 6.95374995470047 10529213 10.1021/bi991422s 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, Broom_S605.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 10906 1885 130 D102N Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.8 3.51 2.58 1.44 yes MOPS 30 mM 25.0 DSC Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 12.204999923706055, 6.95374995470047 10529213 10.1021/bi991422s 1999 ProTherm 13539 1885 130 D102N Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.39 3.19 3.53 1.48 yes MOPS 30 mM 20.0 DSC Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 12.204999923706055, 6.95374995470047 10529213 10.1021/bi991422s 1999 ProTherm 13750 1885 130 D102N Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.39 3.1 yes MOPS 30 mM 15.0 DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 12.204999923706055, 6.95374995470047 10529213 10.1021/bi991422s 1999 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, SAAFEC_S1262.csv 13879 1885 130 D102N Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.01 3.1 1.41 yes MOPS 30 mM 15.0 DSC Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 12.204999923706055, 6.95374995470047 10529213 10.1021/bi991422s 1999 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, SAAFEC_S1262.csv 13882 1885 130 D102N Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.01 3.09 4.25 1.41 yes MOPS 30 mM 15.0 DSC Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 12.204999923706055, 6.95374995470047 10529213 10.1021/bi991422s 1999 ProTherm SAAFEC_S1262.csv 14087 1885 130 D102N Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.3 2.87 5.0 1.52 yes MOPS 30 mM 10.0 DSC Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 12.204999923706055, 6.95374995470047 10529213 10.1021/bi991422s 1999 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv 14217 1885 130 D102N Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.63 2.77 5.55 1.53 yes MOPS 30 mM 5.0 DSC Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 12.204999923706055, 6.95374995470047 10529213 10.1021/bi991422s 1999 ProTherm 3634 1886 130 D102S Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 77.6 -13.6 yes 37.2 MOPS 30 mM DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 12.204999923706055, 6.95374995470047 10529213 10.1021/bi991422s 1999 ProTherm AUTOMUTE_S1962.csv, Broom_S605.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 13751 1886 130 D102S Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.39 3.1 yes MOPS 30 mM 15.0 DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 12.204999923706055, 6.95374995470047 10529213 10.1021/bi991422s 1999 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 13880 1886 130 D102S Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.99 3.3 1.36 yes MOPS 30 mM 15.0 DSC Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 12.204999923706055, 6.95374995470047 10529213 10.1021/bi991422s 1999 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 3635 1887 130 D102A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 71.1 -15.2 yes 35.6 MOPS 30 mM DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 12.204999923706055, 6.95374995470047 10529213 10.1021/bi991422s 1999 ProTherm AUTOMUTE_S1962.csv, Broom_S605.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 13752 1887 130 D102A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.39 3.8 yes MOPS 30 mM 15.0 DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 12.204999923706055, 6.95374995470047 10529213 10.1021/bi991422s 1999 ProTherm capriotti_S1615_map.csv 13881 1887 130 D102A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.57 3.7 1.42 yes MOPS 30 mM 15.0 DSC Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 12.204999923706055, 6.95374995470047 10529213 10.1021/bi991422s 1999 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 439 246 130 V104A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) -7.9 Unknown 43.3 MOPS 30 mM CD Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 14.67857129233224, 9.691428661346436 11513591 10.1021/bi010565n 2001 ProTherm 8741 246 130 V104A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.08 Unknown MOPS 30 mM 25.0 CD Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 14.67857129233224, 9.691428661346436 11513591 10.1021/bi010565n 2001 ProTherm SAAFEC_S1262.csv 12520 246 130 V104A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.05 3.8 2.6 1.23 yes 2.0 MOPS 30mM 25.0 Fluorescence Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 14.67857129233224, 9.691428661346436 21377472 10.1016/j.jmb.2011.02.053 2011 ProTherm 12523 246 130 V104A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.78 4.5 5.0 1.34 yes 2.0 Acetate 30mM 25.0 Fluorescence Urea 5.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 14.67857129233224, 9.691428661346436 21377472 10.1016/j.jmb.2011.02.053 2011 ProTherm 440 247 130 V104S Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) -16.6 Unknown 34.6 MOPS 30 mM CD Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 14.67857129233224, 9.691428661346436 11513591 10.1021/bi010565n 2001 ProTherm 8742 247 130 V104S Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.73 Unknown MOPS 30 mM 25.0 CD Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 14.67857129233224, 9.691428661346436 11513591 10.1021/bi010565n 2001 ProTherm SAAFEC_S1262.csv 441 248 130 V104T Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) -9.8 yes(0.98) 41.4 MOPS 30 mM CD Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 14.67857129233224, 9.691428661346436 11513591 10.1021/bi010565n 2001 ProTherm 449 248 130 V104T Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) -11.3 yes(0.98) 40.2 MOPS 30 mM DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 14.67857129233224, 9.691428661346436 11513591 10.1021/bi010565n 2001 ProTherm 8743 248 130 V104T Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.08 yes(0.98) MOPS 30 mM 25.0 CD Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 14.67857129233224, 9.691428661346436 11513591 10.1021/bi010565n 2001 ProTherm SAAFEC_S1262.csv 8752 248 130 V104T Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.29 3.1 yes(0.98) MOPS 30 mM 25.0 DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 14.67857129233224, 9.691428661346436 11513591 10.1021/bi010565n 2001 ProTherm khan_protherm_data_mapped.csv 8744 3836 130 V104C Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.67 Unknown MOPS 30 mM 25.0 CD Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 14.67857129233224, 9.691428661346436 11513591 10.1021/bi010565n 2001 ProTherm SAAFEC_S1262.csv 1070 653 130 N107A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 91.0 -8.6 yes 42.3 MOPS 30 mM Fluorescence Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 6.0 1YGW, 1RN1, 9RNT 14.754999876022339, 11.987499952316284 1731929 10.1021/bi00118a013 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7634 653 130 N107A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.91 yes MOPS 30 mM 50.9 Fluorescence Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 6.0 1YGW, 1RN1, 9RNT 14.754999876022339, 11.987499952316284 1731929 10.1021/bi00118a013 1992 ProTherm capriotti_S1615_map.csv 8904 653 130 N107A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.92 2.87 1.44 yes MOPS 30 mM 25.0 Fluorescence Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 6.0 1YGW, 1RN1, 9RNT 14.754999876022339, 11.987499952316284 1731929 10.1021/bi00118a013 1992 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 12521 5802 130 L112A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.7 4.3 2.1 1.23 yes 2.0 MOPS 30mM 25.0 Fluorescence Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 4.0 1YGW, 1RN1, 9RNT 16.241250038146973, 12.433749914169312 21377472 10.1016/j.jmb.2011.02.053 2011 ProTherm 4212 2137 130 G114R Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.8 yes(>90%) 64.0 phosphate DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 7.0 1YGW, 1RN1, 9RNT 12.664999961853027, 11.722500085830688 in pocket 10747991 10.1074/jbc.M001132200 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 442 249 130 V115S Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) -21.6 Unknown 29.6 MOPS 30 mM CD Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5.0 1YGW, 1RN1, 9RNT 12.661428587777275, 8.865714209420341 in pocket 11513591 10.1021/bi010565n 2001 ProTherm 8745 249 130 V115S Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.87 Unknown MOPS 30 mM 25.0 CD Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5.0 1YGW, 1RN1, 9RNT 12.661428587777275, 8.865714209420341 in pocket 11513591 10.1021/bi010565n 2001 ProTherm SAAFEC_S1262.csv 443 250 130 V115T Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) -13.2 Unknown 38.0 MOPS 30 mM CD Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5.0 1YGW, 1RN1, 9RNT 12.661428587777275, 8.865714209420341 in pocket 11513591 10.1021/bi010565n 2001 ProTherm 8746 250 130 V115T Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.07 Unknown MOPS 30 mM 25.0 CD Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5.0 1YGW, 1RN1, 9RNT 12.661428587777275, 8.865714209420341 in pocket 11513591 10.1021/bi010565n 2001 ProTherm SAAFEC_S1262.csv 444 251 130 V115C Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) -4.9 Unknown 46.3 MOPS 30 mM CD Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5.0 1YGW, 1RN1, 9RNT 12.661428587777275, 8.865714209420341 in pocket 11513591 10.1021/bi010565n 2001 ProTherm 8747 251 130 V115C Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.54 Unknown MOPS 30 mM 25.0 CD Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 5.0 1YGW, 1RN1, 9RNT 12.661428587777275, 8.865714209420341 in pocket 11513591 10.1021/bi010565n 2001 ProTherm SAAFEC_S1262.csv 12522 5803 130 I116V Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.49 1.2 5.2 1.23 yes 2.0 MOPS 30mM 25.0 Fluorescence Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0 1YGW, 1RN1, 9RNT 12.43500006198883, 8.410000085830688 in tunnel in pocket 21377472 10.1016/j.jmb.2011.02.053 2011 ProTherm 4597 2308 130 T117A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.2 98.0 -10.6 yes 2.0 41.9 MOPS 30000.0 DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 12.392857142857142, 7.345714228493827 24591301 10.1002/pro.2449 2014 ProTherm 11510 2308 130 T117A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.32 2.9 1.25 yes 2.0 MOPS 30000.0 25.0 Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 12.392857142857142, 7.345714228493827 24591301 10.1002/pro.2449 2014 ProTherm 4598 2309 130 T117V Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.6 95.0 -11.8 yes 2.0 40.7 MOPS 30000.0 DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 12.392857142857142, 7.345714228493827 24591301 10.1002/pro.2449 2014 ProTherm 11511 2309 130 T117V Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.07 2.6 1.24 yes 2.0 MOPS 30000.0 25.0 Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0 1YGW, 1RN1, 9RNT 12.392857142857142, 7.345714228493827 24591301 10.1002/pro.2449 2014 ProTherm 16306 7690 130 T117A, T119A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.7 96.0 -12.0 yes 2.0 40.5 MOPS 30000.0 DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0, 8.0 1YGW, 1RN1, 9RNT 12.392857142857142, 13.332856859479632, 7.345714228493827, 8.842857156481061 24591301 10.1002/pro.2449 2014 ProTherm 17092 7690 130 T117A, T119A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.9 2.3 1.21 yes 2.0 MOPS 30000.0 25.0 Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0, 8.0 1YGW, 1RN1, 9RNT 12.392857142857142, 13.332856859479632, 7.345714228493827, 8.842857156481061 24591301 10.1002/pro.2449 2014 ProTherm 16307 7691 130 T117A, T119V Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.4 90.0 -11.0 yes 2.0 41.4 MOPS 30000.0 DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0, 8.0 1YGW, 1RN1, 9RNT 12.392857142857142, 13.332856859479632, 7.345714228493827, 8.842857156481061 24591301 10.1002/pro.2449 2014 ProTherm 17093 7691 130 T117A, T119V Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.35 2.9 1.21 yes 2.0 MOPS 30000.0 25.0 Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0, 8.0 1YGW, 1RN1, 9RNT 12.392857142857142, 13.332856859479632, 7.345714228493827, 8.842857156481061 24591301 10.1002/pro.2449 2014 ProTherm 16308 7692 130 T117V, T119A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.3 92.0 -14.0 yes 2.0 38.5 MOPS 30000.0 DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0, 8.0 1YGW, 1RN1, 9RNT 12.392857142857142, 13.332856859479632, 7.345714228493827, 8.842857156481061 24591301 10.1002/pro.2449 2014 ProTherm 17094 7692 130 T117V, T119A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.9 2.5 1.33 yes 2.0 MOPS 30000.0 25.0 Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0, 8.0 1YGW, 1RN1, 9RNT 12.392857142857142, 13.332856859479632, 7.345714228493827, 8.842857156481061 24591301 10.1002/pro.2449 2014 ProTherm 16309 7693 130 T117V, T119V Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 3.5 94.0 -11.3 yes 2.0 41.2 MOPS 30000.0 DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0, 8.0 1YGW, 1RN1, 9RNT 12.392857142857142, 13.332856859479632, 7.345714228493827, 8.842857156481061 24591301 10.1002/pro.2449 2014 ProTherm 17095 7693 130 T117V, T119V Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 2.19 2.9 1.32 yes 2.0 MOPS 30000.0 25.0 Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 9.0, 8.0 1YGW, 1RN1, 9RNT 12.392857142857142, 13.332856859479632, 7.345714228493827, 8.842857156481061 24591301 10.1002/pro.2449 2014 ProTherm 34 34 130 H118A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 92.5 -1.3 yes 55.9 sodium acetate, calcium acetate 20 mM, 2 mM Mops 50 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 Proton donor 9.0 1YGW, 1RN1, 9RNT 13.583999919891358, 11.221999979019165 in tunnel 8125111 10.1111/j.1432-1033.1994.tb18652.x 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8553 34 130 H118A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.98 0.62 yes sodium acetate, calcium acetate 20 mM, 2 mM 25.0 Mops 50 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 Proton donor 9.0 1YGW, 1RN1, 9RNT 13.583999919891358, 11.221999979019165 in tunnel 8125111 10.1111/j.1432-1033.1994.tb18652.x 1994 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8559 34 130 H118A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.98 7.19 yes sodium acetate, calcium acetate 20 mM, 2 mM 25.0 Mops 50 mM DSC Thermal 6.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 Proton donor 9.0 1YGW, 1RN1, 9RNT 13.583999919891358, 11.221999979019165 in tunnel 8125111 10.1111/j.1432-1033.1994.tb18652.x 1994 ProTherm 4599 2310 130 T119A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 0.7 104.0 -2.3 yes 2.0 50.2 MOPS 30000.0 DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0 1YGW, 1RN1, 9RNT 13.332856859479632, 8.842857156481061 24591301 10.1002/pro.2449 2014 ProTherm 11512 2310 130 T119A Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.46 4.1 0.91 yes 2.0 MOPS 30000.0 25.0 Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0 1YGW, 1RN1, 9RNT 13.332856859479632, 8.842857156481061 24591301 10.1002/pro.2449 2014 ProTherm 4600 2311 130 T119V Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 1.0 97.0 -3.2 yes 2.0 49.3 MOPS 30000.0 DSC Thermal 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0 1YGW, 1RN1, 9RNT 13.332856859479632, 8.842857156481061 24591301 10.1002/pro.2449 2014 ProTherm 11513 2311 130 T119V Guanyl-specific ribonuclease T1 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 4.16 5.0 1.2 yes 2.0 MOPS 30000.0 25.0 Urea 7.0 4.6.1.24 P00651 IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR051386:Ribonuclease_N1/T1, IPR048269:RNase_U2 8.0 1YGW, 1RN1, 9RNT 13.332856859479632, 8.842857156481061 24591301 10.1002/pro.2449 2014 ProTherm 17433 37 214 Adenylate kinase Escherichia coli (strain K12) 95.0 Unknown 51.8 HEPES 0.05 mM DSC Thermal 7.2 2.7.4.3 P69441 IPR006259:Adenyl_kin_sub, IPR000850:Adenylat/UMP-CMP_kin, IPR033690:Adenylat_kinase_CS, IPR007862:Adenylate_kinase_lid-dom, IPR027417:P-loop_NTPase 1748642 1991 ProTherm 18368 37 214 Adenylate kinase Escherichia coli (strain K12) 95.0 158.0 Unknown 51.8 HEPES 50 mM DSC Thermal 7.4 2.7.4.3 P69441 IPR006259:Adenyl_kin_sub, IPR000850:Adenylat/UMP-CMP_kin, IPR033690:Adenylat_kinase_CS, IPR007862:Adenylate_kinase_lid-dom, IPR027417:P-loop_NTPase 2542263 1989 ProTherm 24967 37 214 Adenylate kinase Escherichia coli (strain K12) Unknown 2.0 42.55 HEPES 20mM Intensity Thermal 7.5 2.7.4.3 P69441 IPR006259:Adenyl_kin_sub, IPR000850:Adenylat/UMP-CMP_kin, IPR033690:Adenylat_kinase_CS, IPR007862:Adenylate_kinase_lid-dom, IPR027417:P-loop_NTPase 28232526 10.1126/science.aai7825 2017 ProTherm 37 37 214 D84H Adenylate kinase Escherichia coli (strain K12) 63.0 -7.2 Unknown 44.6 HEPES 0.05 mM DSC Thermal 7.2 2.7.4.3 P69441 IPR006259:Adenyl_kin_sub, IPR000850:Adenylat/UMP-CMP_kin, IPR033690:Adenylat_kinase_CS, IPR007862:Adenylate_kinase_lid-dom, IPR027417:P-loop_NTPase 9.0 1ANK 7.2222221692403155 in tunnel in pocket 1748642 1991 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7496 37 214 D84H Adenylate kinase Escherichia coli (strain K12) 1.4 Unknown HEPES 0.05 mM 51.8 DSC Thermal 7.2 2.7.4.3 P69441 IPR006259:Adenyl_kin_sub, IPR000850:Adenylat/UMP-CMP_kin, IPR033690:Adenylat_kinase_CS, IPR007862:Adenylate_kinase_lid-dom, IPR027417:P-loop_NTPase 9.0 1ANK 7.2222221692403155 in tunnel in pocket 1748642 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 35 35 214 G85V Adenylate kinase Escherichia coli (strain K12) 70.0 -11.1 Unknown 40.7 HEPES 0.05 mM DSC Thermal 7.2 2.7.4.3 P69441 IPR006259:Adenyl_kin_sub, IPR000850:Adenylat/UMP-CMP_kin, IPR033690:Adenylat_kinase_CS, IPR007862:Adenylate_kinase_lid-dom, IPR027417:P-loop_NTPase binding site 9.0 1ANK 3.839999961853027 in tunnel in pocket 1748642 1991 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7497 35 214 G85V Adenylate kinase Escherichia coli (strain K12) 2.4 Unknown HEPES 0.05 mM 51.8 DSC Thermal 7.2 2.7.4.3 P69441 IPR006259:Adenyl_kin_sub, IPR000850:Adenylat/UMP-CMP_kin, IPR033690:Adenylat_kinase_CS, IPR007862:Adenylate_kinase_lid-dom, IPR027417:P-loop_NTPase binding site 9.0 1ANK 3.839999961853027 in tunnel in pocket 1748642 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 36 36 214 F86L Adenylate kinase Escherichia coli (strain K12) 97.0 -2.6 Unknown 49.2 HEPES 0.05 mM DSC Thermal 7.2 2.7.4.3 P69441 IPR006259:Adenyl_kin_sub, IPR000850:Adenylat/UMP-CMP_kin, IPR033690:Adenylat_kinase_CS, IPR007862:Adenylate_kinase_lid-dom, IPR027417:P-loop_NTPase binding site 8.0 1ANK 3.0416666865348816 in tunnel in pocket 1748642 1991 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7498 36 214 F86L Adenylate kinase Escherichia coli (strain K12) 0.8 Unknown HEPES 0.05 mM 51.8 DSC Thermal 7.2 2.7.4.3 P69441 IPR006259:Adenyl_kin_sub, IPR000850:Adenylat/UMP-CMP_kin, IPR033690:Adenylat_kinase_CS, IPR007862:Adenylate_kinase_lid-dom, IPR027417:P-loop_NTPase binding site 8.0 1ANK 3.0416666865348816 in tunnel in pocket 1748642 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3114 1665 214 R88G Adenylate kinase Escherichia coli (strain K12) 75.0 161.0 -0.8 Unknown 51.0 HEPES 50 mM DSC Thermal 7.4 2.7.4.3 P69441 IPR006259:Adenyl_kin_sub, IPR000850:Adenylat/UMP-CMP_kin, IPR033690:Adenylat_kinase_CS, IPR007862:Adenylate_kinase_lid-dom, IPR027417:P-loop_NTPase binding site 9.0 1ANK 3.523529459448422 in tunnel in pocket 2542263 1989 ProTherm AUTOMUTE_S1962.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, Broom_S605.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7505 1665 214 R88G Adenylate kinase Escherichia coli (strain K12) 0.2 Unknown HEPES 50 mM 51.8 DSC Thermal 7.4 2.7.4.3 P69441 IPR006259:Adenyl_kin_sub, IPR000850:Adenylat/UMP-CMP_kin, IPR033690:Adenylat_kinase_CS, IPR007862:Adenylate_kinase_lid-dom, IPR027417:P-loop_NTPase binding site 9.0 1ANK 3.523529459448422 in tunnel in pocket 2542263 1989 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 17466 41 164 Endolysin Enterobacteria phage T4 2.5 118.8 yes 51.8 Potassium phosphate 0.020 M KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1553543 10.1126/science.1553543 1992 ProTherm 17473 41 164 Endolysin Enterobacteria phage T4 yes 50.9 Potassium phosphate 20 mM KCl 25 mM CD Thermal 2.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm 17474 41 164 Endolysin Enterobacteria phage T4 yes 66.7 Potassium phosphate 20 mM KCl 25 mM CD Thermal 5.3 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm 17511 41 164 Endolysin Enterobacteria phage T4 118.0 yes 51.65 H3PO4,KH2PO4, 3 mM,17 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1570293 10.1073/pnas.89.9.3751 1992 ProTherm 17512 41 164 Endolysin Enterobacteria phage T4 127.0 yes 62.2 KH2PO4 0.01 M KCl 0.15 M CD Thermal 6.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1570293 10.1073/pnas.89.9.3751 1992 ProTherm 17590 41 164 Endolysin Enterobacteria phage T4 3.38 78.5 86.35 yes 32.92 KH2PO4 20 mM KCl 25 mM DSC Thermal 1.6 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2665807 10.1021/bi00435a024 1989 ProTherm 17591 41 164 Endolysin Enterobacteria phage T4 2.38 83.0 83.83 yes 35.51 KH2PO4 20 mM KCl 25 mM DSC Thermal 1.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2665807 10.1021/bi00435a024 1989 ProTherm 17592 41 164 Endolysin Enterobacteria phage T4 2.47 87.7 88.58 yes 35.61 KH2PO4 20 mM KCl 25 mM DSC Thermal 1.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2665807 10.1021/bi00435a024 1989 ProTherm 17593 41 164 Endolysin Enterobacteria phage T4 2.8 87.5 88.38 yes 35.5 KH2PO4 20 mM KCl 25 mM DSC Thermal 1.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2665807 10.1021/bi00435a024 1989 ProTherm 17594 41 164 Endolysin Enterobacteria phage T4 2.67 87.3 88.17 yes 35.66 KH2PO4 20 mM KCl 25 mM DSC Thermal 1.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2665807 10.1021/bi00435a024 1989 ProTherm 17595 41 164 Endolysin Enterobacteria phage T4 3.03 87.9 88.78 yes 35.72 KH2PO4 20 mM KCl 25 mM DSC Thermal 1.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2665807 10.1021/bi00435a024 1989 ProTherm 17596 41 164 Endolysin Enterobacteria phage T4 1.93 95.7 88.96 yes 39.1 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2665807 10.1021/bi00435a024 1989 ProTherm 17597 41 164 Endolysin Enterobacteria phage T4 2.84 98.5 89.64 yes 38.35 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2665807 10.1021/bi00435a024 1989 ProTherm 17598 41 164 Endolysin Enterobacteria phage T4 1.99 98.5 89.64 yes 39.17 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2665807 10.1021/bi00435a024 1989 ProTherm 17599 41 164 Endolysin Enterobacteria phage T4 2.9 93.1 87.51 yes 37.89 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2665807 10.1021/bi00435a024 1989 ProTherm 17600 41 164 Endolysin Enterobacteria phage T4 1.95 99.7 90.73 yes 38.71 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2665807 10.1021/bi00435a024 1989 ProTherm 17601 41 164 Endolysin Enterobacteria phage T4 2.59 96.9 88.18 yes 39.22 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2665807 10.1021/bi00435a024 1989 ProTherm 17602 41 164 Endolysin Enterobacteria phage T4 2.59 96.9 88.18 yes 38.81 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2665807 10.1021/bi00435a024 1989 ProTherm 17603 41 164 Endolysin Enterobacteria phage T4 2.27 101.9 90.69 yes 40.55 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.2 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2665807 10.1021/bi00435a024 1989 ProTherm 17604 41 164 Endolysin Enterobacteria phage T4 2.53 111.3 93.49 yes 42.94 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.34 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2665807 10.1021/bi00435a024 1989 ProTherm 17605 41 164 Endolysin Enterobacteria phage T4 2.44 114.3 102.87 yes 43.5 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2665807 10.1021/bi00435a024 1989 ProTherm 17606 41 164 Endolysin Enterobacteria phage T4 2.59 114.1 98.13 yes 43.67 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2665807 10.1021/bi00435a024 1989 ProTherm 17607 41 164 Endolysin Enterobacteria phage T4 2.43 114.3 98.3 yes 43.93 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2665807 10.1021/bi00435a024 1989 ProTherm 17608 41 164 Endolysin Enterobacteria phage T4 2.56 114.3 100.58 yes 44.18 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2665807 10.1021/bi00435a024 1989 ProTherm 17609 41 164 Endolysin Enterobacteria phage T4 1.9 113.1 98.4 yes 44.92 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2665807 10.1021/bi00435a024 1989 ProTherm 17610 41 164 Endolysin Enterobacteria phage T4 1.78 118.4 97.09 yes 45.22 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2665807 10.1021/bi00435a024 1989 ProTherm 17611 41 164 Endolysin Enterobacteria phage T4 2.43 113.7 90.96 yes 45.16 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2665807 10.1021/bi00435a024 1989 ProTherm 17612 41 164 Endolysin Enterobacteria phage T4 2.11 113.3 91.77 yes 45.66 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2665807 10.1021/bi00435a024 1989 ProTherm 17613 41 164 Endolysin Enterobacteria phage T4 2.16 117.2 107.82 yes 48.37 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2665807 10.1021/bi00435a024 1989 ProTherm 17614 41 164 Endolysin Enterobacteria phage T4 2.27 115.2 108.29 yes 48.45 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2665807 10.1021/bi00435a024 1989 ProTherm 17615 41 164 Endolysin Enterobacteria phage T4 2.52 116.7 101.53 yes 48.65 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2665807 10.1021/bi00435a024 1989 ProTherm 17616 41 164 Endolysin Enterobacteria phage T4 2.23 113.9 100.23 yes 48.75 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2665807 10.1021/bi00435a024 1989 ProTherm 17617 41 164 Endolysin Enterobacteria phage T4 2.47 110.7 100.74 yes 48.9 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2665807 10.1021/bi00435a024 1989 ProTherm 17618 41 164 Endolysin Enterobacteria phage T4 2.34 113.9 95.68 yes 49.06 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2665807 10.1021/bi00435a024 1989 ProTherm 17619 41 164 Endolysin Enterobacteria phage T4 2.54 123.4 111.06 yes 51.76 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.84 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2665807 10.1021/bi00435a024 1989 ProTherm 17620 41 164 Endolysin Enterobacteria phage T4 2.46 123.8 102.75 yes 51.59 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.84 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2665807 10.1021/bi00435a024 1989 ProTherm 17687 41 164 Endolysin Enterobacteria phage T4 3.5 134.0 Unknown 65.15 Sodium acetate 10 mM NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7507755 10.1002/pro.5560021221 1993 ProTherm 17688 41 164 Endolysin Enterobacteria phage T4 3.5 Unknown 62.19 Potassium phosphate 0.01 M KCl 0.15 M CD Thermal 6.78 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7507755 10.1002/pro.5560021221 1993 ProTherm 17790 41 164 Endolysin Enterobacteria phage T4 2.1 122.0 Unknown 46.85 Unknown CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7306671 10.1002/bip.1981.360200921 1981 ProTherm 17791 41 164 Endolysin Enterobacteria phage T4 2.26 77.9 Unknown 46.85 Unknown CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7306671 10.1002/bip.1981.360200921 1981 ProTherm 17792 41 164 Endolysin Enterobacteria phage T4 2.1 Unknown 37.0 Unknown CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7306671 10.1002/bip.1981.360200921 1981 ProTherm 17793 41 164 Endolysin Enterobacteria phage T4 2.26 Unknown 59.0 Unknown CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7306671 10.1002/bip.1981.360200921 1981 ProTherm 17914 41 164 Endolysin Enterobacteria phage T4 2.5 130.0 Unknown 65.3 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 0.1 M CD Thermal 5.42 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8901549 10.1073/pnas.93.22.12155 1996 ProTherm 17915 41 164 Endolysin Enterobacteria phage T4 2.5 132.0 yes 65.3 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8676387 10.1006/jmbi.1996.0338 1996 ProTherm 17941 41 164 Endolysin Enterobacteria phage T4 114.0 yes 51.65 H3PO4,KH2PO4, 0.0029 M,0.017 M, KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7869383 10.1006/jmbi.1994.0087 1995 ProTherm 17974 41 164 Endolysin Enterobacteria phage T4 87.0 yes 42.0 H3PO4 17 mM KCl 0.15 M CD Thermal 2.1 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8460110 10.1002/prot.340150407 1993 ProTherm 17975 41 164 Endolysin Enterobacteria phage T4 144.0 yes 66.3 KH2PO4 10 mM KCl 0.15 M CD Thermal 5.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8460110 10.1002/prot.340150407 1993 ProTherm 17976 41 164 Endolysin Enterobacteria phage T4 117.0 yes 51.7 H3PO4,KH2PO4, 3 M,17 M, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8401213 10.1002/pro.5560020811 1993 ProTherm 17977 41 164 Endolysin Enterobacteria phage T4 134.0 yes 65.09 Sodium acetate 10 mM NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8401213 10.1002/pro.5560020811 1993 ProTherm 17978 41 164 Endolysin Enterobacteria phage T4 113.0 yes 51.55 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8218201 10.1021/bi00093a013 1993 ProTherm 17989 41 164 Endolysin Enterobacteria phage T4 yes 51.7 Potassium phosphate 20 mM KCl 0.2 M CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8259514 10.1126/science.8259514 1993 ProTherm 17997 41 164 Endolysin Enterobacteria phage T4 yes 38.5 HCl 10 mM KCl 150 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1733941 1992 ProTherm 17998 41 164 Endolysin Enterobacteria phage T4 yes 63.2 Potassium phosphate 10 mM KCl 150 mM CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1733941 1992 ProTherm 17999 41 164 Endolysin Enterobacteria phage T4 yes 57.5 Potassium phosphate 10 mM KCl 150 mM CD Thermal 3.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1733941 1992 ProTherm 18000 41 164 Endolysin Enterobacteria phage T4 yes 62.2 Potassium phosphate 10 mM KCl 150 mM CD Thermal 4.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1733941 1992 ProTherm 18001 41 164 Endolysin Enterobacteria phage T4 yes 65.7 Potassium phosphate 10 mM KCl 150 mM CD Thermal 5.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1733941 1992 ProTherm 18006 41 164 Endolysin Enterobacteria phage T4 yes 56.8 Unknown NaCl 0.2 M CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6726809 10.1016/0022-2836(84)90474-1 1984 ProTherm 18012 41 164 Endolysin Enterobacteria phage T4 yes 51.76 phosphate 20 mM KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm 18013 41 164 Endolysin Enterobacteria phage T4 yes 64.89 phosphate 10 mM KCl 0.2 M CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm 18017 41 164 Endolysin Enterobacteria phage T4 107.0 yes 42.6 Sodium phosphate 0.2 M NaCl 0.5 M CD Thermal 2.2 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 911878 10.1016/0005-2795(77)90166-0 1977 ProTherm 18018 41 164 Endolysin Enterobacteria phage T4 122.0 yes 46.2 Sodium phosphate 0.2 M NaCl 0.5 M CD Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 911878 10.1016/0005-2795(77)90166-0 1977 ProTherm 18019 41 164 Endolysin Enterobacteria phage T4 2.0 89.0 yes 41.9 KH2PO4 100 mM KCl 100 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3477797 10.1073/pnas.84.19.6663 1987 ProTherm 18020 41 164 Endolysin Enterobacteria phage T4 2.0 129.0 yes 64.7 KH2PO4 100 mM KCl 100 mM CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3477797 10.1073/pnas.84.19.6663 1987 ProTherm 18042 41 164 Endolysin Enterobacteria phage T4 2.4 86.0 yes 40.75 Unknown KCl 0.2 M CD Thermal 2.02 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1304917 10.1002/pro.5560010608 1992 ProTherm 18045 41 164 Endolysin Enterobacteria phage T4 1.8 117.0 yes 51.6 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1747370 10.1021/bi00113a006 1991 ProTherm 18046 41 164 Endolysin Enterobacteria phage T4 1.8 138.0 yes 64.6 Potassium phosphate 20 mM KCl 25 mM CD Thermal 4.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1747370 10.1021/bi00113a006 1991 ProTherm 18047 41 164 Endolysin Enterobacteria phage T4 1.8 135.0 yes 65.3 Potassium phosphate 20 mM KCl 25 mM CD Thermal 5.3 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1747370 10.1021/bi00113a006 1991 ProTherm 18048 41 164 Endolysin Enterobacteria phage T4 1.8 121.0 yes(50-75%) 61.9 Potassium phosphate 20 mM KCl 25 mM CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1747370 10.1021/bi00113a006 1991 ProTherm 18049 41 164 Endolysin Enterobacteria phage T4 1.8 79.5 yes(20%) 47.9 Potassium phosphate 20 mM KCl 25 mM CD Thermal 10.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1747370 10.1021/bi00113a006 1991 ProTherm 18051 41 164 Endolysin Enterobacteria phage T4 yes 65.3 Potassium phosphate 20 mM KCl 25 mM CD Thermal 5.31 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1991123 10.1021/bi00219a037 1991 ProTherm 18052 41 164 Endolysin Enterobacteria phage T4 yes 51.6 HCl CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3323816 10.1016/0076-6879(87)54093-9 1987 ProTherm 18053 41 164 Endolysin Enterobacteria phage T4 yes 42.0 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3118211 10.1038/330041a0 1987 ProTherm 18054 41 164 Endolysin Enterobacteria phage T4 yes 62.8 Sodium acetate 20 mM KCl 0.2 M CD Thermal 4.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3681997 10.1016/0022-2836(87)90126-4 1987 ProTherm 18055 41 164 Endolysin Enterobacteria phage T4 yes 64.5 Potassium phosphate 20 mM KCl 0.2 M CD Thermal 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3681997 10.1016/0022-2836(87)90126-4 1987 ProTherm 18060 41 164 Endolysin Enterobacteria phage T4 yes 41.9 KH2PO4 100 mM KCl 100 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2511328 10.1016/0022-2836(89)90299-4 1989 ProTherm 18061 41 164 Endolysin Enterobacteria phage T4 yes 64.7 KH2PO4 100 mM KCl 100 mM CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2511328 10.1016/0022-2836(89)90299-4 1989 ProTherm 18062 41 164 Endolysin Enterobacteria phage T4 87.0 yes 41.4 Unknown KCl 0.2 M CD Thermal 1.99 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2682639 10.1073/pnas.86.21.8237 1989 ProTherm 18063 41 164 Endolysin Enterobacteria phage T4 yes 52.1 Unknown KCl 0.2 M CD Thermal 2.86 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2682639 10.1073/pnas.86.21.8237 1989 ProTherm 18077 41 164 Endolysin Enterobacteria phage T4 yes 41.9 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3405287 10.1038/334406a0 1988 ProTherm 18078 41 164 Endolysin Enterobacteria phage T4 yes 64.7 Unknown KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3405287 10.1038/334406a0 1988 ProTherm 18084 41 164 Endolysin Enterobacteria phage T4 89.0 yes 41.9 H3PO4,HCl, 10 mM,10 mM, KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1457724 10.1002/bip.360321103 1992 ProTherm 18085 41 164 Endolysin Enterobacteria phage T4 129.0 yes 64.7 Potassium phosphate 10 mM KCl 0.15 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1457724 10.1002/bip.360321103 1992 ProTherm 18087 41 164 Endolysin Enterobacteria phage T4 yes 65.0 Unknown KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3277175 10.1073/pnas.85.2.401 1988 ProTherm 18088 41 164 Endolysin Enterobacteria phage T4 yes 39.5 HCl 0.01 N KCl 200 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1911773 10.1021/bi00105a002 1991 ProTherm 18089 41 164 Endolysin Enterobacteria phage T4 yes 62.4 HCl 0.01 N KCl 200 mM CD Thermal 6.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1911773 10.1021/bi00105a002 1991 ProTherm 18090 41 164 Endolysin Enterobacteria phage T4 yes 41.9 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3680274 10.2210/pdb1l16/pdb 1987 ProTherm 18091 41 164 Endolysin Enterobacteria phage T4 yes 64.7 Unknown KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3680274 10.2210/pdb1l16/pdb 1987 ProTherm 18092 41 164 Endolysin Enterobacteria phage T4 yes 42.0 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3277275 10.1126/science.3277275 1988 ProTherm 18093 41 164 Endolysin Enterobacteria phage T4 yes 63.0 Unknown KCl 0.2 M CD Thermal 4.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3277275 10.1126/science.3277275 1988 ProTherm 18094 41 164 Endolysin Enterobacteria phage T4 yes 66.0 Unknown KCl 0.2 M CD Thermal 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3277275 10.1126/science.3277275 1988 ProTherm 18095 41 164 Endolysin Enterobacteria phage T4 yes 38.8 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1993203 10.1021/bi00221a022 1991 ProTherm 18096 41 164 Endolysin Enterobacteria phage T4 yes 46.2 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1993203 10.1021/bi00221a022 1991 ProTherm 18097 41 164 Endolysin Enterobacteria phage T4 yes 53.6 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1993203 10.1021/bi00221a022 1991 ProTherm 18098 41 164 Endolysin Enterobacteria phage T4 yes 38.75 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1420185 10.1021/bi00159a009 1992 ProTherm 18099 41 164 Endolysin Enterobacteria phage T4 yes 46.16 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1420185 10.1021/bi00159a009 1992 ProTherm 18100 41 164 Endolysin Enterobacteria phage T4 yes 53.56 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1420185 10.1021/bi00159a009 1992 ProTherm 18101 41 164 Endolysin Enterobacteria phage T4 yes 38.8 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1737020 10.1021/bi00121a009 1992 ProTherm 18102 41 164 Endolysin Enterobacteria phage T4 yes 46.2 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1737020 10.1021/bi00121a009 1992 ProTherm 18103 41 164 Endolysin Enterobacteria phage T4 yes 53.6 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1737020 10.1021/bi00121a009 1992 ProTherm 18104 41 164 Endolysin Enterobacteria phage T4 1.8 127.0 Unknown 53.42 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8771182 10.1093/protein/8.10.1017 1995 ProTherm 18105 41 164 Endolysin Enterobacteria phage T4 2.5 140.0 Unknown 66.51 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8771182 10.1093/protein/8.10.1017 1995 ProTherm 18106 41 164 Endolysin Enterobacteria phage T4 3.5 140.0 yes 66.48 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7831309 10.1073/pnas.92.2.452 1995 ProTherm 18107 41 164 Endolysin Enterobacteria phage T4 3.5 131.0 yes 65.1 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7831309 10.1073/pnas.92.2.452 1995 ProTherm 18108 41 164 Endolysin Enterobacteria phage T4 114.0 yes 51.68 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8289284 10.1006/jmbi.1994.1016 1994 ProTherm 18109 41 164 Endolysin Enterobacteria phage T4 127.0 yes 53.08 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8289284 10.1006/jmbi.1994.1016 1994 ProTherm 18110 41 164 Endolysin Enterobacteria phage T4 119.0 yes 51.76 KH2PO4 20 mM KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8433369 10.1006/jmbi.1993.1077 1993 ProTherm 18111 41 164 Endolysin Enterobacteria phage T4 133.0 yes 64.88 KH2PO4 10 mM KCl 20 mM CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8433369 10.1006/jmbi.1993.1077 1993 ProTherm 18112 41 164 Endolysin Enterobacteria phage T4 yes 41.0 KCl-HCl KCl 15 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1567817 10.1021/bi00129a006 1992 ProTherm 18113 41 164 Endolysin Enterobacteria phage T4 yes 63.0 Potassium phosphate 10 mM KCl 15 mM CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1567817 10.1021/bi00129a006 1992 ProTherm 18114 41 164 Endolysin Enterobacteria phage T4 130.8 yes 54.1 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1920439 10.1016/0022-2836(91)80079-a 1991 ProTherm 18115 41 164 Endolysin Enterobacteria phage T4 82.9 Unknown 41.47 Unknown KCl 0.2 M CD Thermal 2.03 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2326253 10.1002/prot.340070208 1990 ProTherm 18116 41 164 Endolysin Enterobacteria phage T4 108.0 Unknown 51.1 Unknown KCl 0.2 M CD Thermal 2.83 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2326253 10.1002/prot.340070208 1990 ProTherm 18189 41 164 Endolysin Enterobacteria phage T4 yes 65.1 Sodium acetate 10 mM NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8298466 10.1002/pro.5560021222 1993 ProTherm 18237 41 164 Endolysin Enterobacteria phage T4 130.0 Yes(80%) 2.0 65.3 acetic acid, sodium acetate 1.4 mM, 8.6 mM Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10545167 10.1021/bi9915519 1999 ProTherm 18302 41 164 Endolysin Enterobacteria phage T4 yes 41.9 phosphate 50 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7074100 10.1021/bi00535a054 1982 ProTherm 18357 41 164 Endolysin Enterobacteria phage T4 yes 38.8 cacodylate 50 mM NaCl 0.2 M Fluorescence Thermal 6.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2334694 10.1021/bi00465a026 1990 ProTherm 18374 41 164 Endolysin Enterobacteria phage T4 1.8 113.0 Unknown 51.7 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9514271 10.1002/pro.5560070117 1998 ProTherm 18384 41 164 Endolysin Enterobacteria phage T4 yes 40.9 HCl 0.01 N KCl 200 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1911773 10.1021/bi00105a002 1991 ProTherm 18385 41 164 Endolysin Enterobacteria phage T4 yes 66.1 phosphate 10 mM KCl 150 mM CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1911773 10.1021/bi00105a002 1991 ProTherm 18425 41 164 Endolysin Enterobacteria phage T4 99.0 yes 40.4 HCl 10 mM KCl 0.15 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1854726 10.1021/bi00243a015 1991 ProTherm 18426 41 164 Endolysin Enterobacteria phage T4 123.0 yes 52.6 Potassium phosphate 10 mM KCl 0.15 M CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1854726 10.1021/bi00243a015 1991 ProTherm 18427 41 164 Endolysin Enterobacteria phage T4 143.0 yes 63.6 acetate 10 mM KCl 0.15 M CD Thermal 4.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1854726 10.1021/bi00243a015 1991 ProTherm 18428 41 164 Endolysin Enterobacteria phage T4 142.0 yes 66.7 acetate 10 mM KCl 0.15 M CD Thermal 5.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1854726 10.1021/bi00243a015 1991 ProTherm 18429 41 164 Endolysin Enterobacteria phage T4 125.0 yes 64.6 Potassium phosphate 10 mM KCl 0.15 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1854726 10.1021/bi00243a015 1991 ProTherm 18447 41 164 Endolysin Enterobacteria phage T4 yes 66.0 Potassium phosphate 10 mM KCl 0.15 M CD Thermal 5.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2337607 10.1021/bi00461a025 1990 ProTherm 18518 41 164 Endolysin Enterobacteria phage T4 2.67 86.7 87.6 yes 35.6 KH2PO4 20 mM KCl 25 mM DSC Thermal 1.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2665807 10.1021/bi00435a024 1989 ProTherm 18519 41 164 Endolysin Enterobacteria phage T4 2.4 97.0 89.1 yes 38.75 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2665807 10.1021/bi00435a024 1989 ProTherm 18520 41 164 Endolysin Enterobacteria phage T4 2.27 101.9 90.7 yes 40.55 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.2 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2665807 10.1021/bi00435a024 1989 ProTherm 18521 41 164 Endolysin Enterobacteria phage T4 2.53 111.3 93.5 yes 42.94 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.34 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2665807 10.1021/bi00435a024 1989 ProTherm 18522 41 164 Endolysin Enterobacteria phage T4 2.49 114.2 99.7 yes 43.7 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2665807 10.1021/bi00435a024 1989 ProTherm 18523 41 164 Endolysin Enterobacteria phage T4 2.16 114.6 95.8 yes 45.03 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2665807 10.1021/bi00435a024 1989 ProTherm 18524 41 164 Endolysin Enterobacteria phage T4 2.33 114.6 102.4 yes 48.7 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2665807 10.1021/bi00435a024 1989 ProTherm 18525 41 164 Endolysin Enterobacteria phage T4 2.5 123.6 106.9 yes 51.68 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.84 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2665807 10.1021/bi00435a024 1989 ProTherm 18711 41 164 Endolysin Enterobacteria phage T4 86.0 yes 40.8 HCl KCl 0.20 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1998663 10.1021/bi00222a001 1991 ProTherm 18805 41 164 Endolysin Enterobacteria phage T4 113.6 yes (>90%) 45.0 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8241117 10.1021/bi00097a006 1993 ProTherm 18806 41 164 Endolysin Enterobacteria phage T4 84.0 yes (>90%) 44.0 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8241117 10.1021/bi00097a006 1993 ProTherm 18807 41 164 Endolysin Enterobacteria phage T4 68.0 yes (>90%) 40.1 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8241117 10.1021/bi00097a006 1993 ProTherm 18854 41 164 Endolysin Enterobacteria phage T4 Unknown 47.8 Potassium phosphate 20 mM KCl 25 mM CD Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7918421 10.1021/bi00206a003 1994 ProTherm 18982 41 164 Endolysin Enterobacteria phage T4 yes 36.4 Potassium phosphate 20 mM KCl 25 mM CD Thermal 2.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1510962 10.1021/bi00149a004 1992 ProTherm 19212 41 164 Endolysin Enterobacteria phage T4 yes 65.3 Sodium acetate,Acetic acid, 8.6 mM,1.4 mM, NaCl 0.10 M DSC Thermal 5.42 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10556025 10.1006/jmbi.1999.3220 1999 ProTherm 19318 41 164 Endolysin Enterobacteria phage T4 113.0 yes 51.7 phosphoric acid,Potassium phosphate, 3 mM,17 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10623513 10.1006/jmbi.1999.3300 2000 ProTherm 19347 41 164 Endolysin Enterobacteria phage T4 113.0 yes(>95%) 51.7 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10512706 10.1006/jmbi.1999.3102 1999 ProTherm 19348 41 164 Endolysin Enterobacteria phage T4 128.0 yes(>80%) 65.2 Sodium acetate 10 mM NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10512706 10.1006/jmbi.1999.3102 1999 ProTherm 19500 41 164 Endolysin Enterobacteria phage T4 no 65.0 Potassium phosphate 10 mM KCl 0.15 M CD Thermal 7.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8845764 10.1002/pro.5560050419 1996 ProTherm 19506 41 164 Endolysin Enterobacteria phage T4 103.01 yes 41.7 glycine-HCl 20 mM DSC Thermal 2.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8889173 10.1016/S0006-3495(96)79397-9 1996 ProTherm 19507 41 164 Endolysin Enterobacteria phage T4 111.85 yes 45.6 glycine-HCl 20 mM DSC Thermal 2.6 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8889173 10.1016/S0006-3495(96)79397-9 1996 ProTherm 19508 41 164 Endolysin Enterobacteria phage T4 120.22 yes 49.8 glycine-HCl 20 mM DSC Thermal 2.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8889173 10.1016/S0006-3495(96)79397-9 1996 ProTherm 19509 41 164 Endolysin Enterobacteria phage T4 127.39 yes 54.1 glycine-HCl 20 mM DSC Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8889173 10.1016/S0006-3495(96)79397-9 1996 ProTherm 19510 41 164 Endolysin Enterobacteria phage T4 134.08 yes 59.4 glycine-HCl 20 mM DSC Thermal 3.3 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8889173 10.1016/S0006-3495(96)79397-9 1996 ProTherm 19511 41 164 Endolysin Enterobacteria phage T4 136.47 yes 62.1 glycine-HCl 20 mM DSC Thermal 3.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8889173 10.1016/S0006-3495(96)79397-9 1996 ProTherm 19512 41 164 Endolysin Enterobacteria phage T4 138.86 yes 64.6 glycine-HCl 20 mM DSC Thermal 3.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8889173 10.1016/S0006-3495(96)79397-9 1996 ProTherm 20089 41 164 Endolysin Enterobacteria phage T4 yes 2.0 41.9 Phosphate buffer 50 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1737005 10.1021/bi00120a025 1992 ProTherm 20162 41 164 Endolysin Enterobacteria phage T4 2.35 yes Unknown 47.0 NaCl 0.2 M CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6726809 10.1016/0022-2836(84)90474-1 1984 ProTherm 21120 41 164 Endolysin Enterobacteria phage T4 11.1 3.6 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21121 41 164 Endolysin Enterobacteria phage T4 15.0 5.5 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21122 41 164 Endolysin Enterobacteria phage T4 14.8 5.1 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21123 41 164 Endolysin Enterobacteria phage T4 15.5 5.7 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21124 41 164 Endolysin Enterobacteria phage T4 13.9 4.7 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21125 41 164 Endolysin Enterobacteria phage T4 14.5 5.3 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21126 41 164 Endolysin Enterobacteria phage T4 15.8 5.9 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21127 41 164 Endolysin Enterobacteria phage T4 14.8 5.6 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21128 41 164 Endolysin Enterobacteria phage T4 11.1 3.3 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21129 41 164 Endolysin Enterobacteria phage T4 9.4 2.7 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21130 41 164 Endolysin Enterobacteria phage T4 6.8 1.4 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21131 41 164 Endolysin Enterobacteria phage T4 10.8 3.5 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21132 41 164 Endolysin Enterobacteria phage T4 5.6 1.4 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21133 41 164 Endolysin Enterobacteria phage T4 8.3 2.2 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21134 41 164 Endolysin Enterobacteria phage T4 8.2 2.0 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21135 41 164 Endolysin Enterobacteria phage T4 8.3 2.1 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21136 41 164 Endolysin Enterobacteria phage T4 7.7 2.1 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21137 41 164 Endolysin Enterobacteria phage T4 9.5 2.7 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21138 41 164 Endolysin Enterobacteria phage T4 7.7 2.3 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21139 41 164 Endolysin Enterobacteria phage T4 7.6 1.8 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21140 41 164 Endolysin Enterobacteria phage T4 5.4 1.0 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21141 41 164 Endolysin Enterobacteria phage T4 9.5 2.6 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21142 41 164 Endolysin Enterobacteria phage T4 7.4 1.9 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21143 41 164 Endolysin Enterobacteria phage T4 8.6 2.6 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21144 41 164 Endolysin Enterobacteria phage T4 6.6 1.5 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21145 41 164 Endolysin Enterobacteria phage T4 9.8 2.5 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21146 41 164 Endolysin Enterobacteria phage T4 7.7 1.6 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21147 41 164 Endolysin Enterobacteria phage T4 8.5 2.3 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21148 41 164 Endolysin Enterobacteria phage T4 4.2 0.5 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21149 41 164 Endolysin Enterobacteria phage T4 9.4 2.8 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21150 41 164 Endolysin Enterobacteria phage T4 8.8 2.5 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21151 41 164 Endolysin Enterobacteria phage T4 9.2 2.8 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21152 41 164 Endolysin Enterobacteria phage T4 10.5 2.9 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21153 41 164 Endolysin Enterobacteria phage T4 10.0 2.9 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21154 41 164 Endolysin Enterobacteria phage T4 9.6 2.6 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21155 41 164 Endolysin Enterobacteria phage T4 15.9 5.9 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21156 41 164 Endolysin Enterobacteria phage T4 12.9 4.4 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21157 41 164 Endolysin Enterobacteria phage T4 12.7 4.1 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21158 41 164 Endolysin Enterobacteria phage T4 15.2 5.6 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21159 41 164 Endolysin Enterobacteria phage T4 16.0 6.1 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21160 41 164 Endolysin Enterobacteria phage T4 17.2 6.4 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21161 41 164 Endolysin Enterobacteria phage T4 16.4 5.9 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21162 41 164 Endolysin Enterobacteria phage T4 14.7 5.3 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21163 41 164 Endolysin Enterobacteria phage T4 16.2 5.8 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21164 41 164 Endolysin Enterobacteria phage T4 15.9 5.4 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21165 41 164 Endolysin Enterobacteria phage T4 16.9 6.4 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21166 41 164 Endolysin Enterobacteria phage T4 16.3 6.4 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21167 41 164 Endolysin Enterobacteria phage T4 14.2 4.9 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21168 41 164 Endolysin Enterobacteria phage T4 10.9 2.7 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21169 41 164 Endolysin Enterobacteria phage T4 14.6 5.2 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21170 41 164 Endolysin Enterobacteria phage T4 15.1 5.3 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21171 41 164 Endolysin Enterobacteria phage T4 14.3 5.0 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21172 41 164 Endolysin Enterobacteria phage T4 14.0 4.9 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21173 41 164 Endolysin Enterobacteria phage T4 16.9 6.0 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21174 41 164 Endolysin Enterobacteria phage T4 16.6 5.8 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21175 41 164 Endolysin Enterobacteria phage T4 17.7 6.5 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21176 41 164 Endolysin Enterobacteria phage T4 16.1 6.0 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21177 41 164 Endolysin Enterobacteria phage T4 18.3 7.3 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21178 41 164 Endolysin Enterobacteria phage T4 16.4 5.8 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21179 41 164 Endolysin Enterobacteria phage T4 16.8 6.0 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21180 41 164 Endolysin Enterobacteria phage T4 16.5 6.2 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21181 41 164 Endolysin Enterobacteria phage T4 17.1 6.5 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21182 41 164 Endolysin Enterobacteria phage T4 15.1 5.2 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21183 41 164 Endolysin Enterobacteria phage T4 15.6 5.4 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21184 41 164 Endolysin Enterobacteria phage T4 13.9 4.9 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21185 41 164 Endolysin Enterobacteria phage T4 15.3 5.6 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21186 41 164 Endolysin Enterobacteria phage T4 13.5 4.6 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21187 41 164 Endolysin Enterobacteria phage T4 15.3 5.1 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21188 41 164 Endolysin Enterobacteria phage T4 10.4 2.6 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21189 41 164 Endolysin Enterobacteria phage T4 10.1 2.9 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21190 41 164 Endolysin Enterobacteria phage T4 12.1 3.7 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21191 41 164 Endolysin Enterobacteria phage T4 12.4 4.0 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21192 41 164 Endolysin Enterobacteria phage T4 14.1 5.0 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21193 41 164 Endolysin Enterobacteria phage T4 16.1 5.8 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21194 41 164 Endolysin Enterobacteria phage T4 16.3 6.2 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21195 41 164 Endolysin Enterobacteria phage T4 14.5 5.4 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21196 41 164 Endolysin Enterobacteria phage T4 13.3 4.6 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21197 41 164 Endolysin Enterobacteria phage T4 13.0 4.0 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21198 41 164 Endolysin Enterobacteria phage T4 15.0 5.3 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21199 41 164 Endolysin Enterobacteria phage T4 13.5 4.3 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21200 41 164 Endolysin Enterobacteria phage T4 12.5 3.9 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21201 41 164 Endolysin Enterobacteria phage T4 14.1 4.5 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21202 41 164 Endolysin Enterobacteria phage T4 13.0 4.2 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21203 41 164 Endolysin Enterobacteria phage T4 14.4 5.0 Unknown Sodium phosphate 50 mM 25.0 KCl 0.1 M NMR GdnHCl 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 10542101 10.1038/14956 1999 ProTherm 21253 41 164 Endolysin Enterobacteria phage T4 5.4 16.55 3.07 no Potassium phosphate 10 mM 25.0 KCl 0.15 M CD Urea 7.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8845764 10.1002/pro.5560050419 1996 ProTherm 21555 41 164 Endolysin Enterobacteria phage T4 6.3 Unknown imidazole,MOPS, 0.05 M,0.05 M, 22.0 Gel electrophoresis Urea 7.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1988046 10.1021/bi00216a038 1991 ProTherm 21556 41 164 Endolysin Enterobacteria phage T4 2.2 0.0 5.5 yes (>90%) Tris-HCl 50 mM 22.0 MgCl2 1 mM DSC GdnHCl 7.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8241117 10.1021/bi00097a006 1993 ProTherm 21557 41 164 Endolysin Enterobacteria phage T4 6.3 0.0 2.0 yes (>90%) MOPS-imidazole 0.05 M 22.0 DSC Urea 7.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8241117 10.1021/bi00097a006 1993 ProTherm 21948 41 164 Endolysin Enterobacteria phage T4 2.88 18.2 yes 2.0 Phosphate buffer 50 mM 12.0 CD GdnHCl 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1737005 10.1021/bi00120a025 1992 ProTherm 22243 41 164 Endolysin Enterobacteria phage T4 130.0 Unknown 65.3 sodium acetate 0.010 M NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 11316887 10.1110/ps.02101 2001 ProTherm 22373 41 164 Endolysin Enterobacteria phage T4 yes 67.85 sodium phosphate 50 mM CD Thermal 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 11669649 10.1021/bi010665t 2001 ProTherm 22783 41 164 Endolysin Enterobacteria phage T4 132.0 Unknown 65.5 sodium chloride, acetic acid, sodium acetate 0.10 M, 1.4 mM, 8.6 mM CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 12963380 10.1016/s0022-2836(03)00856-8 2003 ProTherm 22932 41 164 Endolysin Enterobacteria phage T4 2.5 128.0 Unknown 51.6 glycine-HCl 20 mM CD Thermal 3.02 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 15340171 10.1110/ps.04875504 2004 ProTherm 22960 41 164 Endolysin Enterobacteria phage T4 1.8 127.0 yes(>90%) 53.4 KPO4 20.0 mM KCl 25.0 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 12487988 10.1016/s0301-4622(02)00193-x 2002 ProTherm 23948 41 164 Endolysin Enterobacteria phage T4 136.0 Unknown 66.6 Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 19384988 10.1002/pro.94 2009 ProTherm 23949 41 164 Endolysin Enterobacteria phage T4 142.0 Unknown 53.2 Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 19384988 10.1002/pro.94 2009 ProTherm 26416 41 164 Endolysin Enterobacteria phage T4 14.9 2.7 Unknown Potassium phosphate 20 mM 25.0 NaCl 100 mM CD Urea 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 17400925 10.1110/ps.062632807 2007 ProTherm 26417 41 164 Endolysin Enterobacteria phage T4 6.8 1.8 Unknown Potassium phosphate 20 mM 25.0 NaCl 100 mM CD Urea 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 17400925 10.1110/ps.062632807 2007 ProTherm 26418 41 164 Endolysin Enterobacteria phage T4 11.2 2.3 Unknown Potassium phosphate 20 mM 25.0 NaCl 100 mM CD Urea 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 17400925 10.1110/ps.062632807 2007 ProTherm 26419 41 164 Endolysin Enterobacteria phage T4 7.6 4.0 Unknown Potassium phosphate 50 mM 25.0 CD GdnHCl 5.25 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 17400926 10.1110/ps.062628607 2007 ProTherm 27281 41 164 Endolysin Enterobacteria phage T4 2.18 10.98 yes sodium phosphate 50 mM 14.0 CD Thermal 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 11669649 10.1021/bi010665t 2001 ProTherm 711 436 164 I3W Endolysin Enterobacteria phage T4 -16.4 yes 25.5 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 724 436 164 I3W Endolysin Enterobacteria phage T4 -8.0 yes 56.7 Unknown KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6985 436 164 I3W Endolysin Enterobacteria phage T4 2.8 yes Unknown 64.7 KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 712 437 164 I3Y Endolysin Enterobacteria phage T4 -9.5 yes 32.4 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 725 437 164 I3Y Endolysin Enterobacteria phage T4 -5.9 yes 58.8 Unknown KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6986 437 164 I3Y Endolysin Enterobacteria phage T4 2.3 yes Unknown 64.7 KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 8033 437 164 I3Y Endolysin Enterobacteria phage T4 2.7 yes Unknown 41.9 KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm capriotti_S1615_map.csv 713 438 164 I3F Endolysin Enterobacteria phage T4 -4.0 yes 37.9 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 726 438 164 I3F Endolysin Enterobacteria phage T4 -3.0 yes 61.7 Unknown KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 876 438 164 I3F Endolysin Enterobacteria phage T4 -4.68 yes 34.07 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 1420185 10.1021/bi00159a009 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 881 438 164 I3F Endolysin Enterobacteria phage T4 -3.0 yes 43.16 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 1420185 10.1021/bi00159a009 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 886 438 164 I3F Endolysin Enterobacteria phage T4 -1.31 yes 52.25 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 1420185 10.1021/bi00159a009 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3001 438 164 I3F Endolysin Enterobacteria phage T4 -4.0 yes 37.9 phosphate 50 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 7074100 10.1021/bi00535a054 1982 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4660 438 164 I3F Endolysin Enterobacteria phage T4 -4.0 yes 2.0 37.9 Phosphate buffer 50 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 1737005 10.1021/bi00120a025 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6987 438 164 I3F Endolysin Enterobacteria phage T4 1.1 yes Unknown 64.7 KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 7332 438 164 I3F Endolysin Enterobacteria phage T4 2.64 0.53 yes Potassium phosphate 20 mM 53.56 KCl 25 mM DSC Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 1420185 10.1021/bi00159a009 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 7850 438 164 I3F Endolysin Enterobacteria phage T4 2.64 1.09 yes Potassium phosphate 20 mM 46.16 KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 1420185 10.1021/bi00159a009 1992 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 8034 438 164 I3F Endolysin Enterobacteria phage T4 1.0 yes Unknown 41.9 KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 8214 438 164 I3F Endolysin Enterobacteria phage T4 2.64 1.49 yes Potassium phosphate 20 mM 38.75 KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 1420185 10.1021/bi00159a009 1992 ProTherm capriotti_S1615_map.csv 13905 438 164 I3F Endolysin Enterobacteria phage T4 2.61 16.8 yes 2.0 Phosphate buffer 50 mM 12.0 CD GdnHCl 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 1737005 10.1021/bi00120a025 1992 ProTherm 714 439 164 I3L Endolysin Enterobacteria phage T4 3.0 yes 44.9 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 727 439 164 I3L Endolysin Enterobacteria phage T4 0.9 yes 65.6 Unknown KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 877 439 164 I3L Endolysin Enterobacteria phage T4 2.66 yes 41.41 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 1420185 10.1021/bi00159a009 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 882 439 164 I3L Endolysin Enterobacteria phage T4 2.75 yes 48.91 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 1420185 10.1021/bi00159a009 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 887 439 164 I3L Endolysin Enterobacteria phage T4 2.84 yes 56.4 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 1420185 10.1021/bi00159a009 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 902 439 164 I3L Endolysin Enterobacteria phage T4 1.8 132.0 2.11 Unknown 55.53 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 8771182 10.1093/protein/8.10.1017 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 909 439 164 I3L Endolysin Enterobacteria phage T4 2.5 147.0 1.69 Unknown 67.2 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 8771182 10.1093/protein/8.10.1017 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6724 439 164 I3L Endolysin Enterobacteria phage T4 2.5 -0.7 Unknown Acetic acid, Sodium acetate 1.4 mM, 8.6 mM 66.51 NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 8771182 10.1093/protein/8.10.1017 1995 ProTherm capriotti_S1615_map.csv 6988 439 164 I3L Endolysin Enterobacteria phage T4 -0.4 yes Unknown 64.7 KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 7333 439 164 I3L Endolysin Enterobacteria phage T4 2.36 -1.16 yes Potassium phosphate 20 mM 53.56 KCl 25 mM DSC Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 1420185 10.1021/bi00159a009 1992 ProTherm capriotti_S1615_map.csv 7339 439 164 I3L Endolysin Enterobacteria phage T4 1.8 -0.83 Unknown KH2PO4, H3PO4 17 mM, 3 mM 53.42 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 8771182 10.1093/protein/8.10.1017 1995 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 7851 439 164 I3L Endolysin Enterobacteria phage T4 2.36 -1.01 yes Potassium phosphate 20 mM 46.16 KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 1420185 10.1021/bi00159a009 1992 ProTherm capriotti_S1615_map.csv 8035 439 164 I3L Endolysin Enterobacteria phage T4 -0.9 yes Unknown 41.9 KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 8215 439 164 I3L Endolysin Enterobacteria phage T4 2.36 -0.85 yes Potassium phosphate 20 mM 38.75 KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 1420185 10.1021/bi00159a009 1992 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 715 440 164 I3V Endolysin Enterobacteria phage T4 -2.1 yes 39.8 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm EASE-MM_S1676.csv, PON-TStab_dataset.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 728 440 164 I3V Endolysin Enterobacteria phage T4 -1.2 yes 63.5 Unknown KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3000 440 164 I3V Endolysin Enterobacteria phage T4 -2.1 yes 39.8 phosphate 50 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 7074100 10.1021/bi00535a054 1982 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q306.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4659 440 164 I3V Endolysin Enterobacteria phage T4 -2.1 yes 2.0 39.8 Phosphate buffer 50 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 1737005 10.1021/bi00120a025 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6989 440 164 I3V Endolysin Enterobacteria phage T4 0.4 yes Unknown 64.7 KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8036 440 164 I3V Endolysin Enterobacteria phage T4 0.6 yes Unknown 41.9 KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm capriotti_S1615_map.csv 13904 440 164 I3V Endolysin Enterobacteria phage T4 2.78 18.1 yes 2.0 Phosphate buffer 50 mM 12.0 CD GdnHCl 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 1737005 10.1021/bi00120a025 1992 ProTherm 716 441 164 I3M Endolysin Enterobacteria phage T4 -0.9 yes 41.0 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 729 441 164 I3M Endolysin Enterobacteria phage T4 -2.3 yes 62.4 Unknown KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6990 441 164 I3M Endolysin Enterobacteria phage T4 0.9 yes Unknown 64.7 KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm capriotti_S1615_map.csv 8037 441 164 I3M Endolysin Enterobacteria phage T4 0.3 yes Unknown 41.9 KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 717 442 164 I3C Endolysin Enterobacteria phage T4 -1.9 yes 40.0 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 730 442 164 I3C Endolysin Enterobacteria phage T4 -3.7 yes 61.0 Unknown KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6991 442 164 I3C Endolysin Enterobacteria phage T4 1.2 yes Unknown 64.7 KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm 6992 442 164 I3C Endolysin Enterobacteria phage T4 -1.2 yes Unknown 64.7 KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm 8038 442 164 I3C Endolysin Enterobacteria phage T4 0.4 yes Unknown 41.9 KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm khan_protherm_data_mapped.csv 8039 442 164 I3C Endolysin Enterobacteria phage T4 -1.0 yes Unknown 41.9 KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm 718 443 164 I3A Endolysin Enterobacteria phage T4 -3.8 yes 38.1 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 731 443 164 I3A Endolysin Enterobacteria phage T4 3.3 yes 68.0 Unknown KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm 732 443 164 I3A Endolysin Enterobacteria phage T4 -1.8 yes 62.9 Unknown KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3002 443 164 I3A Endolysin Enterobacteria phage T4 -3.8 yes 38.1 phosphate 50 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 7074100 10.1021/bi00535a054 1982 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4661 443 164 I3A Endolysin Enterobacteria phage T4 -3.8 yes 2.0 38.1 Phosphate buffer 50 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 1737005 10.1021/bi00120a025 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6993 443 164 I3A Endolysin Enterobacteria phage T4 0.7 yes Unknown 64.7 KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8040 443 164 I3A Endolysin Enterobacteria phage T4 1.1 yes Unknown 41.9 KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm capriotti_S1615_map.csv 13906 443 164 I3A Endolysin Enterobacteria phage T4 2.52 15.7 yes 2.0 Phosphate buffer 50 mM 12.0 CD GdnHCl 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 1737005 10.1021/bi00120a025 1992 ProTherm 719 444 164 I3T Endolysin Enterobacteria phage T4 -6.1 yes 35.8 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 733 444 164 I3T Endolysin Enterobacteria phage T4 -6.0 yes 58.7 Unknown KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 879 444 164 I3T Endolysin Enterobacteria phage T4 -8.48 yes 30.27 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 1420185 10.1021/bi00159a009 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 884 444 164 I3T Endolysin Enterobacteria phage T4 -6.4 yes 39.76 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 1420185 10.1021/bi00159a009 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 889 444 164 I3T Endolysin Enterobacteria phage T4 -4.32 yes 49.24 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 1420185 10.1021/bi00159a009 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6994 444 164 I3T Endolysin Enterobacteria phage T4 2.3 yes Unknown 64.7 KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, potapov_with_uniprot_mapping.csv 7335 444 164 I3T Endolysin Enterobacteria phage T4 2.98 1.81 yes Potassium phosphate 20 mM 53.56 KCl 25 mM DSC Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 1420185 10.1021/bi00159a009 1992 ProTherm capriotti_S1615_map.csv 7853 444 164 I3T Endolysin Enterobacteria phage T4 2.98 2.28 yes Potassium phosphate 20 mM 46.16 KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 1420185 10.1021/bi00159a009 1992 ProTherm capriotti_S1615_map.csv 8041 444 164 I3T Endolysin Enterobacteria phage T4 1.7 yes Unknown 41.9 KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 8217 444 164 I3T Endolysin Enterobacteria phage T4 2.98 2.45 yes Potassium phosphate 20 mM 38.75 KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 1420185 10.1021/bi00159a009 1992 ProTherm capriotti_S1615_map.csv 720 445 164 I3S Endolysin Enterobacteria phage T4 -7.0 yes 34.9 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 734 445 164 I3S Endolysin Enterobacteria phage T4 -4.6 yes 60.1 Unknown KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6995 445 164 I3S Endolysin Enterobacteria phage T4 1.7 yes Unknown 64.7 KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8042 445 164 I3S Endolysin Enterobacteria phage T4 1.9 yes Unknown 41.9 KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 721 446 164 I3G Endolysin Enterobacteria phage T4 -7.2 yes 34.7 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 735 446 164 I3G Endolysin Enterobacteria phage T4 -5.8 yes 58.9 Unknown KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm AUTOMUTE_S1749.csv, EASE-MM_S238.csv, PON-TStab_dataset.csv, Saraboji_S1791.csv, STRUM_Q306.csv, STRUM_Q3421.csv 3003 446 164 I3G Endolysin Enterobacteria phage T4 -7.2 yes 34.7 phosphate 50 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 7074100 10.1021/bi00535a054 1982 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4662 446 164 I3G Endolysin Enterobacteria phage T4 -7.2 yes 2.0 34.7 Phosphate buffer 50 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 1737005 10.1021/bi00120a025 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6996 446 164 I3G Endolysin Enterobacteria phage T4 2.1 yes Unknown 64.7 KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, potapov_with_uniprot_mapping.csv 8043 446 164 I3G Endolysin Enterobacteria phage T4 1.8 yes Unknown 41.9 KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 13907 446 164 I3G Endolysin Enterobacteria phage T4 2.34 15.9 yes 2.0 Phosphate buffer 50 mM 12.0 CD GdnHCl 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 1737005 10.1021/bi00120a025 1992 ProTherm 722 447 164 I3E Endolysin Enterobacteria phage T4 -4.1 yes 37.8 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 736 447 164 I3E Endolysin Enterobacteria phage T4 -5.7 yes 59.0 Unknown KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 875 447 164 I3E Endolysin Enterobacteria phage T4 -5.69 yes 33.06 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 1420185 10.1021/bi00159a009 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 880 447 164 I3E Endolysin Enterobacteria phage T4 -4.68 yes 41.48 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 1420185 10.1021/bi00159a009 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 885 447 164 I3E Endolysin Enterobacteria phage T4 -3.66 yes 49.9 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 1420185 10.1021/bi00159a009 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6997 447 164 I3E Endolysin Enterobacteria phage T4 2.0 yes Unknown 64.7 KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm capriotti_S1615_map.csv 7331 447 164 I3E Endolysin Enterobacteria phage T4 2.61 1.53 yes Potassium phosphate 20 mM 53.56 KCl 25 mM DSC Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 1420185 10.1021/bi00159a009 1992 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 7849 447 164 I3E Endolysin Enterobacteria phage T4 2.61 1.71 yes Potassium phosphate 20 mM 46.16 KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 1420185 10.1021/bi00159a009 1992 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 8044 447 164 I3E Endolysin Enterobacteria phage T4 1.1 yes Unknown 41.9 KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 8213 447 164 I3E Endolysin Enterobacteria phage T4 2.61 1.77 yes Potassium phosphate 20 mM 38.75 KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 1420185 10.1021/bi00159a009 1992 ProTherm capriotti_S1615_map.csv 723 448 164 I3D Endolysin Enterobacteria phage T4 -6.5 yes 35.4 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 737 448 164 I3D Endolysin Enterobacteria phage T4 -8.5 yes 56.2 Unknown KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6998 448 164 I3D Endolysin Enterobacteria phage T4 3.2 yes Unknown 64.7 KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm capriotti_S1615_map.csv 8045 448 164 I3D Endolysin Enterobacteria phage T4 1.8 yes Unknown 41.9 KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 3405287 10.1038/334406a0 1988 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 878 526 164 I3P Endolysin Enterobacteria phage T4 -11.99 yes 26.76 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 1420185 10.1021/bi00159a009 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 883 526 164 I3P Endolysin Enterobacteria phage T4 -9.2 yes 36.96 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 1420185 10.1021/bi00159a009 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 888 526 164 I3P Endolysin Enterobacteria phage T4 -6.41 yes 47.15 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 1420185 10.1021/bi00159a009 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7334 526 164 I3P Endolysin Enterobacteria phage T4 3.7 2.53 yes Potassium phosphate 20 mM 53.56 KCl 25 mM DSC Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 1420185 10.1021/bi00159a009 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 7852 526 164 I3P Endolysin Enterobacteria phage T4 3.7 2.97 yes Potassium phosphate 20 mM 46.16 KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 1420185 10.1021/bi00159a009 1992 ProTherm capriotti_S1615_map.csv 8216 526 164 I3P Endolysin Enterobacteria phage T4 3.7 2.96 yes Potassium phosphate 20 mM 38.75 KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.899999856948853, 9.90499997138977 1420185 10.1021/bi00159a009 1992 ProTherm capriotti_S1615_map.csv 14560 6774 164 S38D, A82P, N144D, I3L Endolysin Enterobacteria phage T4 1.8 138.0 4.87 Unknown 58.29 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 6.0, 4.0, 6.0 1L63, 2LZM 14.899999856948853, 31.671667098999023, 26.978000259399415, 21.59874975681305, 9.90499997138977, 32.44999980926514, 23.790000343322752, 17.32000035047531 8771182 10.1093/protein/8.10.1017 1995 ProTherm 14567 6774 164 S38D, A82P, N144D, I3L Endolysin Enterobacteria phage T4 2.5 154.0 5.38 Unknown 71.89 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 6.0, 4.0, 6.0 1L63, 2LZM 14.899999856948853, 31.671667098999023, 26.978000259399415, 21.59874975681305, 9.90499997138977, 32.44999980926514, 23.790000343322752, 17.32000035047531 8771182 10.1093/protein/8.10.1017 1995 ProTherm 14898 6774 164 S38D, A82P, N144D, I3L Endolysin Enterobacteria phage T4 2.5 -2.32 Unknown Acetic acid, Sodium acetate 1.4 mM, 8.6 mM 66.51 NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 6.0, 4.0, 6.0 1L63, 2LZM 14.899999856948853, 31.671667098999023, 26.978000259399415, 21.59874975681305, 9.90499997138977, 32.44999980926514, 23.790000343322752, 17.32000035047531 8771182 10.1093/protein/8.10.1017 1995 ProTherm 14979 6774 164 S38D, A82P, N144D, I3L Endolysin Enterobacteria phage T4 1.8 -1.95 Unknown KH2PO4, H3PO4 17 mM, 3 mM 53.42 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 6.0, 4.0, 6.0 1L63, 2LZM 14.899999856948853, 31.671667098999023, 26.978000259399415, 21.59874975681305, 9.90499997138977, 32.44999980926514, 23.790000343322752, 17.32000035047531 8771182 10.1093/protein/8.10.1017 1995 ProTherm 14561 6775 164 S38D, A82P, N144D, I3L, V131A Endolysin Enterobacteria phage T4 1.8 140.0 5.56 Unknown 58.98 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 6.0, 4.0, 2.0, 6.0 1L63, 2LZM 14.899999856948853, 31.671667098999023, 26.978000259399415, 22.488571166992188, 21.59874975681305, 9.90499997138977, 32.44999980926514, 23.790000343322752, 16.635714530944824, 17.32000035047531 in pocket 8771182 10.1093/protein/8.10.1017 1995 ProTherm 14568 6775 164 S38D, A82P, N144D, I3L, V131A Endolysin Enterobacteria phage T4 2.5 150.0 6.06 Unknown 72.57 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 6.0, 4.0, 2.0, 6.0 1L63, 2LZM 14.899999856948853, 31.671667098999023, 26.978000259399415, 22.488571166992188, 21.59874975681305, 9.90499997138977, 32.44999980926514, 23.790000343322752, 16.635714530944824, 17.32000035047531 in pocket 8771182 10.1093/protein/8.10.1017 1995 ProTherm 14899 6775 164 S38D, A82P, N144D, I3L, V131A Endolysin Enterobacteria phage T4 2.5 -2.57 Unknown Acetic acid, Sodium acetate 1.4 mM, 8.6 mM 66.51 NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 6.0, 4.0, 2.0, 6.0 1L63, 2LZM 14.899999856948853, 31.671667098999023, 26.978000259399415, 22.488571166992188, 21.59874975681305, 9.90499997138977, 32.44999980926514, 23.790000343322752, 16.635714530944824, 17.32000035047531 in pocket 8771182 10.1093/protein/8.10.1017 1995 ProTherm 14980 6775 164 S38D, A82P, N144D, I3L, V131A Endolysin Enterobacteria phage T4 1.8 -2.25 Unknown KH2PO4, H3PO4 17 mM, 3 mM 53.42 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 6.0, 4.0, 2.0, 6.0 1L63, 2LZM 14.899999856948853, 31.671667098999023, 26.978000259399415, 22.488571166992188, 21.59874975681305, 9.90499997138977, 32.44999980926514, 23.790000343322752, 16.635714530944824, 17.32000035047531 in pocket 8771182 10.1093/protein/8.10.1017 1995 ProTherm 14562 6776 164 S38D, A82P, N144D, I3L, V131A, A41V Endolysin Enterobacteria phage T4 1.8 139.0 6.5 Unknown 59.92 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 6.0, 4.0, 4.0, 2.0, 6.0 1L63, 2LZM 14.899999856948853, 31.671667098999023, 27.43000030517578, 26.978000259399415, 22.488571166992188, 21.59874975681305, 9.90499997138977, 32.44999980926514, 28.104000091552734, 23.790000343322752, 16.635714530944824, 17.32000035047531 in pocket 8771182 10.1093/protein/8.10.1017 1995 ProTherm 14569 6776 164 S38D, A82P, N144D, I3L, V131A, A41V Endolysin Enterobacteria phage T4 2.5 145.0 6.91 Unknown 73.42 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 6.0, 4.0, 4.0, 2.0, 6.0 1L63, 2LZM 14.899999856948853, 31.671667098999023, 27.43000030517578, 26.978000259399415, 22.488571166992188, 21.59874975681305, 9.90499997138977, 32.44999980926514, 28.104000091552734, 23.790000343322752, 16.635714530944824, 17.32000035047531 in pocket 8771182 10.1093/protein/8.10.1017 1995 ProTherm 14900 6776 164 S38D, A82P, N144D, I3L, V131A, A41V Endolysin Enterobacteria phage T4 2.5 -2.87 Unknown Acetic acid, Sodium acetate 1.4 mM, 8.6 mM 66.51 NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 6.0, 4.0, 4.0, 2.0, 6.0 1L63, 2LZM 14.899999856948853, 31.671667098999023, 27.43000030517578, 26.978000259399415, 22.488571166992188, 21.59874975681305, 9.90499997138977, 32.44999980926514, 28.104000091552734, 23.790000343322752, 16.635714530944824, 17.32000035047531 in pocket 8771182 10.1093/protein/8.10.1017 1995 ProTherm 14981 6776 164 S38D, A82P, N144D, I3L, V131A, A41V Endolysin Enterobacteria phage T4 1.8 -2.62 Unknown KH2PO4, H3PO4 17 mM, 3 mM 53.42 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 6.0, 4.0, 4.0, 2.0, 6.0 1L63, 2LZM 14.899999856948853, 31.671667098999023, 27.43000030517578, 26.978000259399415, 22.488571166992188, 21.59874975681305, 9.90499997138977, 32.44999980926514, 28.104000091552734, 23.790000343322752, 16.635714530944824, 17.32000035047531 in pocket 8771182 10.1093/protein/8.10.1017 1995 ProTherm 14563 6777 164 S38D, A82P, N144D, I3L, V131A, A41V, N116D Endolysin Enterobacteria phage T4 1.8 139.0 7.26 Unknown 60.68 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 6.0, 4.0, 4.0, 7.0, 2.0, 6.0 1L63, 2LZM 14.899999856948853, 31.671667098999023, 27.43000030517578, 26.978000259399415, 24.97124981880188, 22.488571166992188, 21.59874975681305, 9.90499997138977, 32.44999980926514, 28.104000091552734, 23.790000343322752, 24.317500114440918, 16.635714530944824, 17.32000035047531 in pocket 8771182 10.1093/protein/8.10.1017 1995 ProTherm 14570 6777 164 S38D, A82P, N144D, I3L, V131A, A41V, N116D Endolysin Enterobacteria phage T4 2.5 156.0 8.32 Unknown 74.83 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 6.0, 4.0, 4.0, 7.0, 2.0, 6.0 1L63, 2LZM 14.899999856948853, 31.671667098999023, 27.43000030517578, 26.978000259399415, 24.97124981880188, 22.488571166992188, 21.59874975681305, 9.90499997138977, 32.44999980926514, 28.104000091552734, 23.790000343322752, 24.317500114440918, 16.635714530944824, 17.32000035047531 in pocket 8771182 10.1093/protein/8.10.1017 1995 ProTherm 14901 6777 164 S38D, A82P, N144D, I3L, V131A, A41V, N116D Endolysin Enterobacteria phage T4 2.5 -3.57 Unknown Acetic acid, Sodium acetate 1.4 mM, 8.6 mM 66.51 NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 6.0, 4.0, 4.0, 7.0, 2.0, 6.0 1L63, 2LZM 14.899999856948853, 31.671667098999023, 27.43000030517578, 26.978000259399415, 24.97124981880188, 22.488571166992188, 21.59874975681305, 9.90499997138977, 32.44999980926514, 28.104000091552734, 23.790000343322752, 24.317500114440918, 16.635714530944824, 17.32000035047531 in pocket 8771182 10.1093/protein/8.10.1017 1995 ProTherm 14982 6777 164 S38D, A82P, N144D, I3L, V131A, A41V, N116D Endolysin Enterobacteria phage T4 1.8 -2.92 Unknown KH2PO4, H3PO4 17 mM, 3 mM 53.42 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 6.0, 4.0, 4.0, 7.0, 2.0, 6.0 1L63, 2LZM 14.899999856948853, 31.671667098999023, 27.43000030517578, 26.978000259399415, 24.97124981880188, 22.488571166992188, 21.59874975681305, 9.90499997138977, 32.44999980926514, 28.104000091552734, 23.790000343322752, 24.317500114440918, 16.635714530944824, 17.32000035047531 in pocket 8771182 10.1093/protein/8.10.1017 1995 ProTherm 14688 6858 164 I3C, C54V Endolysin Enterobacteria phage T4 2.2 yes 41.0 cacodylate 50 mM NaCl 0.2 M Fluorescence Thermal 6.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 7.0 1L63, 2LZM 14.899999856948853, 28.41428565979004, 9.90499997138977, 30.27166684468587 in pocket 2334694 10.1021/bi00465a026 1990 ProTherm 15316 7102 164 I3C, C54T Endolysin Enterobacteria phage T4 2.94 12.9 yes Sodium phosphate 2 mM 25.0 CD GdnHCl 5.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 7.0 1L63, 2LZM 14.899999856948853, 28.41428565979004, 9.90499997138977, 30.27166684468587 in pocket 2653427 10.1021/bi00428a041 1989 ProTherm 15597 7102 164 I3C, C54T Endolysin Enterobacteria phage T4 3.03 13.2 yes Sodium phosphate 2 mM 20.0 CD GdnHCl 5.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 7.0 1L63, 2LZM 14.899999856948853, 28.41428565979004, 9.90499997138977, 30.27166684468587 in pocket 2653427 10.1021/bi00428a041 1989 ProTherm 15611 7102 164 I3C, C54T Endolysin Enterobacteria phage T4 3.15 14.8 yes Sodium phosphate 2 mM 12.0 CD GdnHCl 5.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 7.0 1L63, 2LZM 14.899999856948853, 28.41428565979004, 9.90499997138977, 30.27166684468587 in pocket 2653427 10.1021/bi00428a041 1989 ProTherm 15624 7102 164 I3C, C54T Endolysin Enterobacteria phage T4 3.09 13.2 yes Sodium phosphate 2 mM 5.0 CD GdnHCl 5.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 7.0 1L63, 2LZM 14.899999856948853, 28.41428565979004, 9.90499997138977, 30.27166684468587 in pocket 2653427 10.1021/bi00428a041 1989 ProTherm 2016 1122 164 M6A Endolysin Enterobacteria phage T4 121.0 -4.5 Yes(80%) 2.0 60.8 acetic acid, sodium acetate 1.4 mM, 8.6 mM Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 13.684999942779541, 10.133749961853027 10545167 10.1021/bi9915519 1999 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, M47andM8_S1810.csv 3137 1122 164 M6A Endolysin Enterobacteria phage T4 1.8 95.0 -5.7 Unknown 46.0 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 13.684999942779541, 10.133749961853027 9514271 10.1002/pro.5560070117 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6783 1122 164 M6A Endolysin Enterobacteria phage T4 1.6 Yes(80%) 2.0 acetic acid, sodium acetate 1.4 mM, 8.6 mM 65.3 Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 13.684999942779541, 10.133749961853027 10545167 10.1021/bi9915519 1999 ProTherm khan_protherm_data_mapped.csv 7571 1122 164 M6A Endolysin Enterobacteria phage T4 1.8 1.9 Unknown Potassium phosphate 20 mM 51.65 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 13.684999942779541, 10.133749961853027 9514271 10.1002/pro.5560070117 1998 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3029 1616 164 M6I Endolysin Enterobacteria phage T4 -3.4 Unknown 62.1 Unknown CD Thermal 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 13.684999942779541, 10.133749961853027 3689874 10.1002/bip.360261104 1987 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6763 1616 164 M6I Endolysin Enterobacteria phage T4 1.38 Unknown Unknown 65.5 CD Thermal 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 13.684999942779541, 10.133749961853027 3689874 10.1002/bip.360261104 1987 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 12602 1616 164 M6I Endolysin Enterobacteria phage T4 3.9 4.78 Unknown imidazole,MOPS, 0.05 M,0.05 M, 22.0 Gel electrophoresis Urea 7.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 13.684999942779541, 10.133749961853027 1988046 10.1021/bi00216a038 1991 ProTherm SAAFEC_S1262.csv 3146 1680 164 M6L Endolysin Enterobacteria phage T4 61.0 -10.6 yes (>95%) 41.1 phosphoric acid,Potassium phosphate, 3 mM,17 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 13.684999942779541, 10.133749961853027 9541409 10.1002/pro.5560070326 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7811 1680 164 M6L Endolysin Enterobacteria phage T4 1.8 2.8 yes (>95%) phosphoric acid, Potassium phosphate 3 mM, 17 mM 47.0 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 13.684999942779541, 10.133749961853027 9541409 10.1002/pro.5560070326 1998 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14679 6849 164 M6I, R96H Endolysin Enterobacteria phage T4 -13.7 Unknown 51.8 Unknown CD Thermal 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 6.0 1L63, 2LZM 13.684999942779541, 19.399999705227938, 10.133749961853027, 19.36909090388905 3689874 10.1002/bip.360261104 1987 ProTherm 14906 6849 164 M6I, R96H Endolysin Enterobacteria phage T4 5.08 Unknown Unknown 65.5 CD Thermal 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 6.0 1L63, 2LZM 13.684999942779541, 19.399999705227938, 10.133749961853027, 19.36909090388905 3689874 10.1002/bip.360261104 1987 ProTherm 2017 1123 164 L7A Endolysin Enterobacteria phage T4 112.0 -6.3 Yes(80%) 2.0 59.0 acetic acid, sodium acetate 1.4 mM, 8.6 mM Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 15.78250002861023, 12.143749952316284 10545167 10.1021/bi9915519 1999 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 3141 1123 164 L7A Endolysin Enterobacteria phage T4 1.8 90.0 -8.1 Unknown 43.6 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 15.78250002861023, 12.143749952316284 9514271 10.1002/pro.5560070117 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6784 1123 164 L7A Endolysin Enterobacteria phage T4 2.3 Yes(80%) 2.0 acetic acid, sodium acetate 1.4 mM, 8.6 mM 65.3 Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 15.78250002861023, 12.143749952316284 10545167 10.1021/bi9915519 1999 ProTherm khan_protherm_data_mapped.csv 7575 1123 164 L7A Endolysin Enterobacteria phage T4 1.8 2.6 Unknown Potassium phosphate 20 mM 51.65 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 15.78250002861023, 12.143749952316284 9514271 10.1002/pro.5560070117 1998 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 10023 1123 164 L7A Endolysin Enterobacteria phage T4 4.1 10.8 2.7 Unknown Potassium phosphate 20 mM 25.0 NaCl 100 mM CD Urea 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 15.78250002861023, 12.143749952316284 17400925 10.1110/ps.062632807 2007 ProTherm 10028 1123 164 L7A Endolysin Enterobacteria phage T4 3.7 7.5 2.3 Unknown Potassium phosphate 20 mM 25.0 NaCl 100 mM CD Urea 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 15.78250002861023, 12.143749952316284 17400925 10.1110/ps.062632807 2007 ProTherm 913 531 164 E11F Endolysin Enterobacteria phage T4 3.5 138.0 4.3 yes 70.78 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme Proton donor/acceptor 9.0 1L63, 2LZM 20.01222218407525, 16.711110962761772 in tunnel in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6728 531 164 E11F Endolysin Enterobacteria phage T4 3.5 -1.7 yes Acetic acid, Sodium acetate 1.4 mM, 8.6 mM 66.48 NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme Proton donor/acceptor 9.0 1L63, 2LZM 20.01222218407525, 16.711110962761772 in tunnel in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 914 532 164 E11M Endolysin Enterobacteria phage T4 3.5 134.0 4.1 yes 70.58 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme Proton donor/acceptor 9.0 1L63, 2LZM 20.01222218407525, 16.711110962761772 in tunnel in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6729 532 164 E11M Endolysin Enterobacteria phage T4 3.5 -1.6 yes Acetic acid, Sodium acetate 1.4 mM, 8.6 mM 66.48 NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme Proton donor/acceptor 9.0 1L63, 2LZM 20.01222218407525, 16.711110962761772 in tunnel in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 915 533 164 E11A Endolysin Enterobacteria phage T4 3.5 137.0 2.6 yes 69.08 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme Proton donor/acceptor 9.0 1L63, 2LZM 20.01222218407525, 16.711110962761772 in tunnel in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6730 533 164 E11A Endolysin Enterobacteria phage T4 3.5 -1.1 yes Acetic acid, Sodium acetate 1.4 mM, 8.6 mM 66.48 NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme Proton donor/acceptor 9.0 1L63, 2LZM 20.01222218407525, 16.711110962761772 in tunnel in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 924 541 164 E11H Endolysin Enterobacteria phage T4 3.5 125.0 0.1 yes 65.2 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme Proton donor/acceptor 9.0 1L63, 2LZM 20.01222218407525, 16.711110962761772 in tunnel in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6830 541 164 E11H Endolysin Enterobacteria phage T4 3.5 -0.1 yes Acetic acid, Sodium acetate 1.4 mM, 8.6 mM 65.1 NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme Proton donor/acceptor 9.0 1L63, 2LZM 20.01222218407525, 16.711110962761772 in tunnel in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 925 542 164 E11N Endolysin Enterobacteria phage T4 3.5 119.0 -0.6 yes 64.5 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme Proton donor/acceptor 9.0 1L63, 2LZM 20.01222218407525, 16.711110962761772 in tunnel in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6831 542 164 E11N Endolysin Enterobacteria phage T4 3.5 0.1 yes Acetic acid, Sodium acetate 1.4 mM, 8.6 mM 65.1 NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme Proton donor/acceptor 9.0 1L63, 2LZM 20.01222218407525, 16.711110962761772 in tunnel in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14539 6766 164 K60H, L13D Endolysin Enterobacteria phage T4 71.0 -6.1 yes 32.4 HCl 10 mM KCl 0.15 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0, 1.0 1L63, 2LZM 32.04374980926514, 42.435555352105034, 23.65874993801117, 33.772222730848526 1854726 10.1021/bi00243a015 1991 ProTherm 14540 6766 164 K60H, L13D Endolysin Enterobacteria phage T4 101.0 -7.1 yes 58.3 HCl 10 mM KCl 0.15 M CD Thermal 5.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0, 1.0 1L63, 2LZM 32.04374980926514, 42.435555352105034, 23.65874993801117, 33.772222730848526 1854726 10.1021/bi00243a015 1991 ProTherm 14541 6766 164 K60H, L13D Endolysin Enterobacteria phage T4 82.0 -7.1 yes 55.9 HCl 10 mM KCl 0.15 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0, 1.0 1L63, 2LZM 32.04374980926514, 42.435555352105034, 23.65874993801117, 33.772222730848526 1854726 10.1021/bi00243a015 1991 ProTherm 14894 6766 164 K60H, L13D Endolysin Enterobacteria phage T4 2.8 yes HCl 10 mM 66.7 KCl 0.15 M CD Thermal 5.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0, 1.0 1L63, 2LZM 32.04374980926514, 42.435555352105034, 23.65874993801117, 33.772222730848526 1854726 10.1021/bi00243a015 1991 ProTherm 14929 6766 164 K60H, L13D Endolysin Enterobacteria phage T4 2.8 yes HCl 10 mM 64.6 KCl 0.15 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0, 1.0 1L63, 2LZM 32.04374980926514, 42.435555352105034, 23.65874993801117, 33.772222730848526 1854726 10.1021/bi00243a015 1991 ProTherm 15109 6766 164 K60H, L13D Endolysin Enterobacteria phage T4 1.5 yes HCl 10 mM 40.4 KCl 0.15 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0, 1.0 1L63, 2LZM 32.04374980926514, 42.435555352105034, 23.65874993801117, 33.772222730848526 1854726 10.1021/bi00243a015 1991 ProTherm 189 95 164 R14K Endolysin Enterobacteria phage T4 3.5 135.0 -0.08 Unknown 65.07 Sodium acetate 10 mM NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 42.02090922268954, 33.48363616249778 in tunnel in pocket 7507755 10.1002/pro.5560021221 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 201 95 164 R14K Endolysin Enterobacteria phage T4 3.5 -0.53 Unknown 61.66 Potassium phosphate 0.01 M KCl 0.15 M CD Thermal 6.78 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 42.02090922268954, 33.48363616249778 in tunnel in pocket 7507755 10.1002/pro.5560021221 1993 ProTherm AUTOMUTE_S1749.csv, HotMuSiC_S1626.csv, Saraboji_S1791.csv 6818 95 164 R14K Endolysin Enterobacteria phage T4 3.5 0.03 Unknown Sodium acetate 10 mM 65.15 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 42.02090922268954, 33.48363616249778 in tunnel in pocket 7507755 10.1002/pro.5560021221 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 15766 7377 164 R14A, K16A, I17A, K19A, T21A, E22A Endolysin Enterobacteria phage T4 2.5 60.0 -7.6 Unknown 44.0 glycine-HCl 20 mM CD Thermal 3.02 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0, 4.0, 5.0, 5.0, 8.0, 6.0 1L63, 2LZM 42.02090922268954, 51.92999998728434, 22.81375026702881, 28.69555558098687, 33.37714304242815, 32.1722223493788, 33.48363616249778, 35.7000003390842, 24.243749856948853, 30.474444283379448, 37.518571036202566, 37.61333359612359 in tunnel in pocket 15340171 10.1110/ps.04875504 2004 ProTherm 16787 7377 164 R14A, K16A, I17A, K19A, T21A, E22A Endolysin Enterobacteria phage T4 2.5 3.0 Unknown glycine-HCl 20 mM 51.6 CD Thermal 3.02 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0, 4.0, 5.0, 5.0, 8.0, 6.0 1L63, 2LZM 42.02090922268954, 51.92999998728434, 22.81375026702881, 28.69555558098687, 33.37714304242815, 32.1722223493788, 33.48363616249778, 35.7000003390842, 24.243749856948853, 30.474444283379448, 37.518571036202566, 37.61333359612359 in tunnel in pocket 15340171 10.1110/ps.04875504 2004 ProTherm 69 55 164 K16E Endolysin Enterobacteria phage T4 -1.5 yes 49.4 Potassium phosphate 20 mM KCl 25 mM CD Thermal 2.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 51.92999998728434, 35.7000003390842 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm HotMuSiC_S1626.csv, potapov_with_uniprot_mapping.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 74 55 164 K16E Endolysin Enterobacteria phage T4 1.1 yes 67.8 Potassium phosphate 20 mM KCl 25 mM CD Thermal 5.3 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 51.92999998728434, 35.7000003390842 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm potapov_with_uniprot_mapping.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6710 55 164 K16E Endolysin Enterobacteria phage T4 -0.5 yes Potassium phosphate 20 mM 66.7 KCl 25 mM CD Thermal 5.3 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 51.92999998728434, 35.7000003390842 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 7614 55 164 K16E Endolysin Enterobacteria phage T4 0.5 yes Potassium phosphate 20 mM 50.9 KCl 25 mM CD Thermal 2.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 51.92999998728434, 35.7000003390842 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 14441 6700 164 K16E, R119E Endolysin Enterobacteria phage T4 -1.8 yes 49.1 Potassium phosphate 20 mM KCl 25 mM CD Thermal 2.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 4.0 1L63, 2LZM 51.92999998728434, 54.452727404507726, 35.7000003390842, 37.932726946744054 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm 14449 6700 164 K16E, R119E Endolysin Enterobacteria phage T4 0.9 yes 67.6 Potassium phosphate 20 mM KCl 25 mM CD Thermal 5.3 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 4.0 1L63, 2LZM 51.92999998728434, 54.452727404507726, 35.7000003390842, 37.932726946744054 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm 14886 6700 164 K16E, R119E Endolysin Enterobacteria phage T4 -0.4 yes Potassium phosphate 20 mM 66.7 KCl 25 mM CD Thermal 5.3 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 4.0 1L63, 2LZM 51.92999998728434, 54.452727404507726, 35.7000003390842, 37.932726946744054 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm 15033 6700 164 K16E, R119E Endolysin Enterobacteria phage T4 0.6 yes Potassium phosphate 20 mM 50.9 KCl 25 mM CD Thermal 2.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 4.0 1L63, 2LZM 51.92999998728434, 54.452727404507726, 35.7000003390842, 37.932726946744054 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm 14442 6701 164 K16E, K135E Endolysin Enterobacteria phage T4 -2.6 yes 48.3 Potassium phosphate 20 mM KCl 25 mM CD Thermal 2.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 5.0 1L63, 2LZM 51.92999998728434, 32.19444444444444, 35.7000003390842, 28.960000144110786 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm 14450 6701 164 K16E, K135E Endolysin Enterobacteria phage T4 -1.6 yes 65.1 Potassium phosphate 20 mM KCl 25 mM CD Thermal 5.3 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 5.0 1L63, 2LZM 51.92999998728434, 32.19444444444444, 35.7000003390842, 28.960000144110786 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm 14887 6701 164 K16E, K135E Endolysin Enterobacteria phage T4 0.7 yes Potassium phosphate 20 mM 66.7 KCl 25 mM CD Thermal 5.3 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 5.0 1L63, 2LZM 51.92999998728434, 32.19444444444444, 35.7000003390842, 28.960000144110786 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm 15034 6701 164 K16E, K135E Endolysin Enterobacteria phage T4 0.9 yes Potassium phosphate 20 mM 50.9 KCl 25 mM CD Thermal 2.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 5.0 1L63, 2LZM 51.92999998728434, 32.19444444444444, 35.7000003390842, 28.960000144110786 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm 14443 6702 164 K16E, R154E Endolysin Enterobacteria phage T4 0.2 yes 51.1 Potassium phosphate 20 mM KCl 25 mM CD Thermal 2.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 5.0 1L63, 2LZM 51.92999998728434, 47.28545448996804, 35.7000003390842, 31.00090928511186 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm 14451 6702 164 K16E, R154E Endolysin Enterobacteria phage T4 -1.9 yes 64.8 Potassium phosphate 20 mM KCl 25 mM CD Thermal 5.3 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 5.0 1L63, 2LZM 51.92999998728434, 47.28545448996804, 35.7000003390842, 31.00090928511186 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm 14888 6702 164 K16E, R154E Endolysin Enterobacteria phage T4 0.8 yes Potassium phosphate 20 mM 66.7 KCl 25 mM CD Thermal 5.3 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 5.0 1L63, 2LZM 51.92999998728434, 47.28545448996804, 35.7000003390842, 31.00090928511186 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm 15035 6702 164 K16E, R154E Endolysin Enterobacteria phage T4 -0.1 yes Potassium phosphate 20 mM 50.9 KCl 25 mM CD Thermal 2.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 5.0 1L63, 2LZM 51.92999998728434, 47.28545448996804, 35.7000003390842, 31.00090928511186 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm 14446 6705 164 K16E, K135E, K147E Endolysin Enterobacteria phage T4 -2.5 yes 48.4 Potassium phosphate 20 mM KCl 25 mM CD Thermal 2.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 5.0, 3.0 1L63, 2LZM 51.92999998728434, 32.19444444444444, 33.90444416469998, 35.7000003390842, 28.960000144110786, 28.260000122918022 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm 14454 6705 164 K16E, K135E, K147E Endolysin Enterobacteria phage T4 -4.0 yes 62.7 Potassium phosphate 20 mM KCl 25 mM CD Thermal 5.3 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 5.0, 3.0 1L63, 2LZM 51.92999998728434, 32.19444444444444, 33.90444416469998, 35.7000003390842, 28.960000144110786, 28.260000122918022 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm 14891 6705 164 K16E, K135E, K147E Endolysin Enterobacteria phage T4 1.7 yes Potassium phosphate 20 mM 66.7 KCl 25 mM CD Thermal 5.3 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 5.0, 3.0 1L63, 2LZM 51.92999998728434, 32.19444444444444, 33.90444416469998, 35.7000003390842, 28.960000144110786, 28.260000122918022 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm 15038 6705 164 K16E, K135E, K147E Endolysin Enterobacteria phage T4 0.8 yes Potassium phosphate 20 mM 50.9 KCl 25 mM CD Thermal 2.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 5.0, 3.0 1L63, 2LZM 51.92999998728434, 32.19444444444444, 33.90444416469998, 35.7000003390842, 28.960000144110786, 28.260000122918022 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm 14448 6707 164 K16E, R119E, K135E, K147E Endolysin Enterobacteria phage T4 -2.6 yes 48.3 Potassium phosphate 20 mM KCl 25 mM CD Thermal 2.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 4.0, 5.0, 3.0 1L63, 2LZM 51.92999998728434, 54.452727404507726, 32.19444444444444, 33.90444416469998, 35.7000003390842, 37.932726946744054, 28.960000144110786, 28.260000122918022 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm 14456 6707 164 K16E, R119E, K135E, K147E Endolysin Enterobacteria phage T4 -2.5 yes 64.2 Potassium phosphate 20 mM KCl 25 mM CD Thermal 5.3 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 4.0, 5.0, 3.0 1L63, 2LZM 51.92999998728434, 54.452727404507726, 32.19444444444444, 33.90444416469998, 35.7000003390842, 37.932726946744054, 28.960000144110786, 28.260000122918022 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm 14893 6707 164 K16E, R119E, K135E, K147E Endolysin Enterobacteria phage T4 1.0 yes Potassium phosphate 20 mM 66.7 KCl 25 mM CD Thermal 5.3 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 4.0, 5.0, 3.0 1L63, 2LZM 51.92999998728434, 54.452727404507726, 32.19444444444444, 33.90444416469998, 35.7000003390842, 37.932726946744054, 28.960000144110786, 28.260000122918022 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm 15040 6707 164 K16E, R119E, K135E, K147E Endolysin Enterobacteria phage T4 0.9 yes Potassium phosphate 20 mM 50.9 KCl 25 mM CD Thermal 2.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 4.0, 5.0, 3.0 1L63, 2LZM 51.92999998728434, 54.452727404507726, 32.19444444444444, 33.90444416469998, 35.7000003390842, 37.932726946744054, 28.960000144110786, 28.260000122918022 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm 2018 1124 164 I17A Endolysin Enterobacteria phage T4 93.0 -6.4 Yes(80%) 2.0 58.9 acetic acid, sodium acetate 1.4 mM, 8.6 mM Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 22.81375026702881, 24.243749856948853 in pocket 10545167 10.1021/bi9915519 1999 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 3124 1124 164 I17A Endolysin Enterobacteria phage T4 1.8 87.0 -8.4 Unknown 43.3 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 22.81375026702881, 24.243749856948853 in pocket 9514271 10.1002/pro.5560070117 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6785 1124 164 I17A Endolysin Enterobacteria phage T4 2.3 Yes(80%) 2.0 acetic acid, sodium acetate 1.4 mM, 8.6 mM 65.3 Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 22.81375026702881, 24.243749856948853 in pocket 10545167 10.1021/bi9915519 1999 ProTherm khan_protherm_data_mapped.csv 7558 1124 164 I17A Endolysin Enterobacteria phage T4 1.8 2.7 Unknown Potassium phosphate 20 mM 51.65 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 22.81375026702881, 24.243749856948853 in pocket 9514271 10.1002/pro.5560070117 1998 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 2037 1137 164 I17M Endolysin Enterobacteria phage T4 102.0 -5.9 Yes(80%) 2.0 59.4 acetic acid, sodium acetate 1.4 mM, 8.6 mM Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 22.81375026702881, 24.243749856948853 in pocket 10545167 10.1021/bi9915519 1999 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 6804 1137 164 I17M Endolysin Enterobacteria phage T4 2.2 Yes(80%) 2.0 acetic acid, sodium acetate 1.4 mM, 8.6 mM 65.3 Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 22.81375026702881, 24.243749856948853 in pocket 10545167 10.1021/bi9915519 1999 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14534 6762 164 T26Q, Y18H Endolysin Enterobacteria phage T4 -3.4 yes 61.9 Potassium phosphate 20 mM KCl 25 mM CD Thermal 5.31 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0, 9.0 1L63, 2LZM 22.958333015441895, 19.73000008719308, 24.455833594004314, 18.565714154924667 in tunnel in pocket 1991123 10.1021/bi00219a037 1991 ProTherm 14535 6763 164 T26Q, Y18D Endolysin Enterobacteria phage T4 -4.0 yes 61.3 Potassium phosphate 20 mM KCl 25 mM CD Thermal 5.31 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0, 9.0 1L63, 2LZM 22.958333015441895, 19.73000008719308, 24.455833594004314, 18.565714154924667 in tunnel in pocket 1991123 10.1021/bi00219a037 1991 ProTherm 926 543 164 D20N Endolysin Enterobacteria phage T4 3.5 139.0 3.1 yes 68.2 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme Proton donor/acceptor 9.0 1L63, 2LZM 20.603749871253967, 30.332500219345093 in tunnel in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6832 543 164 D20N Endolysin Enterobacteria phage T4 3.5 -1.3 yes Acetic acid, Sodium acetate 1.4 mM, 8.6 mM 65.1 NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme Proton donor/acceptor 9.0 1L63, 2LZM 20.603749871253967, 30.332500219345093 in tunnel in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 927 544 164 D20T Endolysin Enterobacteria phage T4 3.5 135.0 2.2 yes 67.3 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme Proton donor/acceptor 9.0 1L63, 2LZM 20.603749871253967, 30.332500219345093 in tunnel in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6833 544 164 D20T Endolysin Enterobacteria phage T4 3.5 -0.9 yes Acetic acid, Sodium acetate 1.4 mM, 8.6 mM 65.1 NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme Proton donor/acceptor 9.0 1L63, 2LZM 20.603749871253967, 30.332500219345093 in tunnel in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 928 545 164 D20S Endolysin Enterobacteria phage T4 3.5 129.0 1.6 yes 66.7 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme Proton donor/acceptor 9.0 1L63, 2LZM 20.603749871253967, 30.332500219345093 in tunnel in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6834 545 164 D20S Endolysin Enterobacteria phage T4 3.5 -0.7 yes Acetic acid, Sodium acetate 1.4 mM, 8.6 mM 65.1 NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme Proton donor/acceptor 9.0 1L63, 2LZM 20.603749871253967, 30.332500219345093 in tunnel in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 929 546 164 D20A Endolysin Enterobacteria phage T4 3.5 127.0 -0.8 yes 64.3 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme Proton donor/acceptor 9.0 1L63, 2LZM 20.603749871253967, 30.332500219345093 in tunnel in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6835 546 164 D20A Endolysin Enterobacteria phage T4 3.5 0.3 yes Acetic acid, Sodium acetate 1.4 mM, 8.6 mM 65.1 NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme Proton donor/acceptor 9.0 1L63, 2LZM 20.603749871253967, 30.332500219345093 in tunnel in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 190 96 164 E22K Endolysin Enterobacteria phage T4 3.5 141.0 1.37 Unknown 66.52 Sodium acetate 10 mM NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 32.1722223493788, 37.61333359612359 in tunnel in pocket 7507755 10.1002/pro.5560021221 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 202 96 164 E22K Endolysin Enterobacteria phage T4 3.5 1.58 Unknown 63.77 Potassium phosphate 0.01 M KCl 0.15 M CD Thermal 6.78 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 32.1722223493788, 37.61333359612359 in tunnel in pocket 7507755 10.1002/pro.5560021221 1993 ProTherm HotMuSiC_S1626.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6819 96 164 E22K Endolysin Enterobacteria phage T4 3.5 -0.57 Unknown Sodium acetate 10 mM 65.15 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 32.1722223493788, 37.61333359612359 in tunnel in pocket 7507755 10.1002/pro.5560021221 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 15767 7378 164 Y24A, Y25A, T26A, I27A Endolysin Enterobacteria phage T4 2.5 55.0 -16.6 Unknown 35.0 glycine-HCl 20 mM CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0, 3.0, 9.0, 8.0 1L63, 2LZM 31.90166648228963, 26.15749994913737, 19.73000008719308, 22.982499718666077, 28.90500005086263, 24.18750007947286, 18.565714154924667, 22.46375012397766 in tunnel in pocket 15340171 10.1110/ps.04875504 2004 ProTherm 16788 7378 164 Y24A, Y25A, T26A, I27A Endolysin Enterobacteria phage T4 2.5 5.5 Unknown glycine-HCl 20 mM 51.6 CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0, 3.0, 9.0, 8.0 1L63, 2LZM 31.90166648228963, 26.15749994913737, 19.73000008719308, 22.982499718666077, 28.90500005086263, 24.18750007947286, 18.565714154924667, 22.46375012397766 in tunnel in pocket 15340171 10.1110/ps.04875504 2004 ProTherm 12603 5830 164 Y25G Endolysin Enterobacteria phage T4 4.0 4.55 Unknown imidazole,MOPS, 0.05 M,0.05 M, 22.0 Gel electrophoresis Urea 7.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 26.15749994913737, 24.18750007947286 in pocket 1988046 10.1021/bi00216a038 1991 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 191 97 164 T26S Endolysin Enterobacteria phage T4 3.5 143.0 1.35 Unknown 66.5 Sodium acetate 10 mM NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 19.73000008719308, 18.565714154924667 in tunnel in pocket 7507755 10.1002/pro.5560021221 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 203 97 164 T26S Endolysin Enterobacteria phage T4 3.5 1.35 Unknown 63.54 Potassium phosphate 0.01 M KCl 0.15 M CD Thermal 6.78 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 19.73000008719308, 18.565714154924667 in tunnel in pocket 7507755 10.1002/pro.5560021221 1993 ProTherm HotMuSiC_S1626.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 1227 97 164 T26S Endolysin Enterobacteria phage T4 1.35 yes 66.45 Sodium acetate 10 mM NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 19.73000008719308, 18.565714154924667 in tunnel in pocket 8298466 10.1002/pro.5560021222 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6820 97 164 T26S Endolysin Enterobacteria phage T4 3.5 -0.57 Unknown Sodium acetate 10 mM 65.15 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 19.73000008719308, 18.565714154924667 in tunnel in pocket 7507755 10.1002/pro.5560021221 1993 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 619 358 164 T26Q Endolysin Enterobacteria phage T4 -0.9 yes 64.4 Potassium phosphate 20 mM KCl 25 mM CD Thermal 5.31 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 19.73000008719308, 18.565714154924667 in tunnel in pocket 1991123 10.1021/bi00219a037 1991 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 2038 1138 164 I27M Endolysin Enterobacteria phage T4 62.0 -10.1 Yes(80%) 2.0 55.2 acetic acid, sodium acetate 1.4 mM, 8.6 mM Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 22.982499718666077, 22.46375012397766 10545167 10.1021/bi9915519 1999 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, EASE-MM_S1676.csv, HotMuSiC_S1626.csv, PoPMuSiC-2.0_S2648.csv 6805 1138 164 I27M Endolysin Enterobacteria phage T4 3.1 Yes(80%) 2.0 acetic acid, sodium acetate 1.4 mM, 8.6 mM 65.3 Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 22.982499718666077, 22.46375012397766 10545167 10.1021/bi9915519 1999 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3125 1674 164 I27A Endolysin Enterobacteria phage T4 1.8 76.0 -10.1 Unknown 41.6 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 22.982499718666077, 22.46375012397766 9514271 10.1002/pro.5560070117 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7559 1674 164 I27A Endolysin Enterobacteria phage T4 1.8 3.1 Unknown Potassium phosphate 20 mM 51.65 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 22.982499718666077, 22.46375012397766 9514271 10.1002/pro.5560070117 1998 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 10020 1674 164 I27A Endolysin Enterobacteria phage T4 3.9 11.0 2.6 Unknown Potassium phosphate 20 mM 25.0 NaCl 100 mM CD Urea 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 22.982499718666077, 22.46375012397766 17400925 10.1110/ps.062632807 2007 ProTherm 10029 1674 164 I27A Endolysin Enterobacteria phage T4 2.4 8.8 2.2 Unknown Potassium phosphate 20 mM 25.0 NaCl 100 mM CD Urea 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 22.982499718666077, 22.46375012397766 17400925 10.1110/ps.062632807 2007 ProTherm 14651 6828 164 I27M, L33M Endolysin Enterobacteria phage T4 61.0 -10.3 Yes(80%) 2.0 55.0 acetic acid, sodium acetate 1.4 mM, 8.6 mM Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 7.0 1L63, 2LZM 22.982499718666077, 19.803749918937683, 22.46375012397766, 17.960000216960907 in tunnel 10545167 10.1021/bi9915519 1999 ProTherm 14912 6828 164 I27M, L33M Endolysin Enterobacteria phage T4 3.1 Yes(80%) 2.0 acetic acid, sodium acetate 1.4 mM, 8.6 mM 65.3 Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 7.0 1L63, 2LZM 22.982499718666077, 19.803749918937683, 22.46375012397766, 17.960000216960907 in tunnel 10545167 10.1021/bi9915519 1999 ProTherm 1499 870 164 G28A Endolysin Enterobacteria phage T4 2.5 109.0 -5.1 Unknown 46.5 glycine-HCl 20 mM CD Thermal 3.02 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 18.65500020980835, 15.355000019073486 15340171 10.1110/ps.04875504 2004 ProTherm 7583 870 164 G28A Endolysin Enterobacteria phage T4 2.5 2.0 Unknown glycine-HCl 20 mM 51.6 CD Thermal 3.02 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 18.65500020980835, 15.355000019073486 15340171 10.1110/ps.04875504 2004 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 15768 7379 164 G28A, I29A, G30A Endolysin Enterobacteria phage T4 2.5 61.0 -15.6 Unknown 36.0 glycine-HCl 20 mM CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0, 7.0, 9.0 1L63, 2LZM 18.65500020980835, 18.825000047683716, 17.05999994277954, 15.355000019073486, 14.598750114440918, 14.324999809265137 in tunnel in pocket 15340171 10.1110/ps.04875504 2004 ProTherm 16789 7379 164 G28A, I29A, G30A Endolysin Enterobacteria phage T4 2.5 5.5 Unknown glycine-HCl 20 mM 51.6 CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0, 7.0, 9.0 1L63, 2LZM 18.65500020980835, 18.825000047683716, 17.05999994277954, 15.355000019073486, 14.598750114440918, 14.324999809265137 in tunnel in pocket 15340171 10.1110/ps.04875504 2004 ProTherm 3126 1675 164 I29A Endolysin Enterobacteria phage T4 1.8 85.0 -8.2 Unknown 43.5 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 18.825000047683716, 14.598750114440918 in tunnel in pocket 9514271 10.1002/pro.5560070117 1998 ProTherm AUTOMUTE_S1962.csv, EASE-MM_S543.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7560 1675 164 I29A Endolysin Enterobacteria phage T4 1.8 2.6 Unknown Potassium phosphate 20 mM 51.65 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 18.825000047683716, 14.598750114440918 in tunnel in pocket 9514271 10.1002/pro.5560070117 1998 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 916 534 164 G30A Endolysin Enterobacteria phage T4 3.5 134.0 0.1 yes 66.58 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.05999994277954, 14.324999809265137 in tunnel in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6731 534 164 G30A Endolysin Enterobacteria phage T4 3.5 -0.1 yes Acetic acid, Sodium acetate 1.4 mM, 8.6 mM 66.48 NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.05999994277954, 14.324999809265137 in tunnel in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 917 535 164 G30F Endolysin Enterobacteria phage T4 3.5 99.0 -4.9 yes 61.58 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.05999994277954, 14.324999809265137 in tunnel in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6732 535 164 G30F Endolysin Enterobacteria phage T4 3.5 1.5 yes Acetic acid, Sodium acetate 1.4 mM, 8.6 mM 66.48 NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.05999994277954, 14.324999809265137 in tunnel in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3420 1778 164 H31N Endolysin Enterobacteria phage T4 -11.0 yes 55.0 Potassium phosphate 10 mM KCl 0.15 M CD Thermal 5.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 16.1460000038147, 15.667999935150146 in tunnel in pocket 2337607 10.1021/bi00461a025 1990 ProTherm AUTOMUTE_S1962.csv, Broom_S605.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6756 1778 164 H31N Endolysin Enterobacteria phage T4 4.0 yes Potassium phosphate 10 mM 66.0 KCl 0.15 M CD Thermal 5.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 16.1460000038147, 15.667999935150146 in tunnel in pocket 2337607 10.1021/bi00461a025 1990 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14713 6883 164 H31N, D70N Endolysin Enterobacteria phage T4 -11.0 yes 55.0 Potassium phosphate 10 mM KCl 0.15 M CD Thermal 5.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0, 9.0 1L63, 2LZM 16.1460000038147, 16.53374981880188, 15.667999935150146, 13.615000009536743 in tunnel in pocket 2337607 10.1021/bi00461a025 1990 ProTherm 14905 6883 164 H31N, D70N Endolysin Enterobacteria phage T4 4.0 yes Potassium phosphate 10 mM 66.0 KCl 0.15 M CD Thermal 5.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0, 9.0 1L63, 2LZM 16.1460000038147, 16.53374981880188, 15.667999935150146, 13.615000009536743 in tunnel in pocket 2337607 10.1021/bi00461a025 1990 ProTherm 15769 7380 164 L32A, L33A, T34A, E108V Endolysin Enterobacteria phage T4 2.5 62.0 -7.6 Unknown 44.0 glycine-HCl 20 mM CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 9.0, 7.0, 7.0, 5.0 1L63, 2LZM 23.68875002861023, 19.803749918937683, 27.231428827558243, 52.43111101786295, 21.760000109672546, 17.960000216960907, 25.431428909301758, 33.343333350287544 in tunnel in pocket 15340171 10.1110/ps.04875504 2004 ProTherm 16790 7380 164 L32A, L33A, T34A, E108V Endolysin Enterobacteria phage T4 2.5 3.0 Unknown glycine-HCl 20 mM 51.6 CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 9.0, 7.0, 7.0, 5.0 1L63, 2LZM 23.68875002861023, 19.803749918937683, 27.231428827558243, 52.43111101786295, 21.760000109672546, 17.960000216960907, 25.431428909301758, 33.343333350287544 in tunnel in pocket 15340171 10.1110/ps.04875504 2004 ProTherm 2019 1125 164 L33A Endolysin Enterobacteria phage T4 83.0 -8.8 Yes(80%) 2.0 56.5 acetic acid, sodium acetate 1.4 mM, 8.6 mM Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 19.803749918937683, 17.960000216960907 in tunnel 10545167 10.1021/bi9915519 1999 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, M47andM8_S1810.csv 3142 1125 164 L33A Endolysin Enterobacteria phage T4 1.8 67.0 -12.3 Unknown 39.4 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 19.803749918937683, 17.960000216960907 in tunnel 9514271 10.1002/pro.5560070117 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6786 1125 164 L33A Endolysin Enterobacteria phage T4 2.9 Yes(80%) 2.0 acetic acid, sodium acetate 1.4 mM, 8.6 mM 65.3 Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 19.803749918937683, 17.960000216960907 in tunnel 10545167 10.1021/bi9915519 1999 ProTherm khan_protherm_data_mapped.csv 7576 1125 164 L33A Endolysin Enterobacteria phage T4 1.8 3.6 Unknown Potassium phosphate 20 mM 51.65 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 19.803749918937683, 17.960000216960907 in tunnel 9514271 10.1002/pro.5560070117 1998 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 2039 1139 164 L33M Endolysin Enterobacteria phage T4 108.0 -5.3 Yes(80%) 2.0 60.0 acetic acid, sodium acetate 1.4 mM, 8.6 mM Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 19.803749918937683, 17.960000216960907 in tunnel 10545167 10.1021/bi9915519 1999 ProTherm AUTOMUTE_S1925.csv, HotMuSiC_S1626.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 6806 1139 164 L33M Endolysin Enterobacteria phage T4 2.0 Yes(80%) 2.0 acetic acid, sodium acetate 1.4 mM, 8.6 mM 65.3 Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 19.803749918937683, 17.960000216960907 in tunnel 10545167 10.1021/bi9915519 1999 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 15790 7396 164 T34A, K35A, S36A, P37A Endolysin Enterobacteria phage T4 1.8 109.0 -1.6 yes(>90%) 51.8 KPO4 20.0 mM KCl 25.0 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 5.0, 4.0, 5.0 1L63, 2LZM 27.231428827558243, 47.70777829488119, 42.93500010172526, 53.960000446864534, 25.431428909301758, 32.621110916137695, 36.1050001780192, 37.090000425066265 in tunnel in pocket 12487988 10.1016/s0301-4622(02)00193-x 2002 ProTherm 16782 7396 164 T34A, K35A, S36A, P37A Endolysin Enterobacteria phage T4 1.8 0.7 yes(>90%) KPO4 20.0 mM 53.4 KCl 25.0 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 5.0, 4.0, 5.0 1L63, 2LZM 27.231428827558243, 47.70777829488119, 42.93500010172526, 53.960000446864534, 25.431428909301758, 32.621110916137695, 36.1050001780192, 37.090000425066265 in tunnel in pocket 12487988 10.1016/s0301-4622(02)00193-x 2002 ProTherm 15791 7397 164 T34A, K35A, S36A, P37A, S38A, N40A, S44A, E45A, D47A, K48A Endolysin Enterobacteria phage T4 1.8 -10.0 yes(>90%) 41.7 KPO4 20.0 mM KCl 25.0 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 5.0, 4.0, 5.0, 6.0, 2.0, 1.0, 4.0, 6.0, 5.0 1L63, 2LZM 27.231428827558243, 47.70777829488119, 42.93500010172526, 53.960000446864534, 31.671667098999023, 53.328750133514404, 27.80999978383382, 24.191111034817165, 21.792500019073486, 19.5099999109904, 25.431428909301758, 32.621110916137695, 36.1050001780192, 37.090000425066265, 32.44999980926514, 40.831249952316284, 29.99500020345052, 21.3122222688463, 27.502500295639038, 17.67888895670573 in tunnel in pocket 12487988 10.1016/s0301-4622(02)00193-x 2002 ProTherm 15792 7398 164 T34A, K35A, S36A, P37A, S38D, N40A, S44A, E45A, D47A, K48A Endolysin Enterobacteria phage T4 1.8 -3.8 yes(>90%) 47.9 KPO4 20.0 mM KCl 25.0 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 5.0, 4.0, 5.0, 6.0, 2.0, 1.0, 4.0, 6.0, 5.0 1L63, 2LZM 27.231428827558243, 47.70777829488119, 42.93500010172526, 53.960000446864534, 31.671667098999023, 53.328750133514404, 27.80999978383382, 24.191111034817165, 21.792500019073486, 19.5099999109904, 25.431428909301758, 32.621110916137695, 36.1050001780192, 37.090000425066265, 32.44999980926514, 40.831249952316284, 29.99500020345052, 21.3122222688463, 27.502500295639038, 17.67888895670573 in tunnel in pocket 12487988 10.1016/s0301-4622(02)00193-x 2002 ProTherm 15793 7399 164 T34A, K35D, S36A, P37A, S38A, N40A, S44A, E45A, D47A, K48A Endolysin Enterobacteria phage T4 1.8 -9.2 yes(>90%) 42.5 KPO4 20.0 mM KCl 25.0 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 5.0, 4.0, 5.0, 6.0, 2.0, 1.0, 4.0, 6.0, 5.0 1L63, 2LZM 27.231428827558243, 47.70777829488119, 42.93500010172526, 53.960000446864534, 31.671667098999023, 53.328750133514404, 27.80999978383382, 24.191111034817165, 21.792500019073486, 19.5099999109904, 25.431428909301758, 32.621110916137695, 36.1050001780192, 37.090000425066265, 32.44999980926514, 40.831249952316284, 29.99500020345052, 21.3122222688463, 27.502500295639038, 17.67888895670573 in tunnel in pocket 12487988 10.1016/s0301-4622(02)00193-x 2002 ProTherm 15794 7400 164 T34A, K35A, S36D, P37A, S38A, N40A, S44A, E45A, D47A, K48A Endolysin Enterobacteria phage T4 1.8 -8.5 yes(>90%) 43.2 KPO4 20.0 mM KCl 25.0 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 5.0, 4.0, 5.0, 6.0, 2.0, 1.0, 4.0, 6.0, 5.0 1L63, 2LZM 27.231428827558243, 47.70777829488119, 42.93500010172526, 53.960000446864534, 31.671667098999023, 53.328750133514404, 27.80999978383382, 24.191111034817165, 21.792500019073486, 19.5099999109904, 25.431428909301758, 32.621110916137695, 36.1050001780192, 37.090000425066265, 32.44999980926514, 40.831249952316284, 29.99500020345052, 21.3122222688463, 27.502500295639038, 17.67888895670573 in tunnel in pocket 12487988 10.1016/s0301-4622(02)00193-x 2002 ProTherm 15795 7401 164 T34A, K35A, S36A, P37D, S38A, N40A, S44A, E45A, D47A, K48A Endolysin Enterobacteria phage T4 1.8 -7.4 yes(>90%) 44.3 KPO4 20.0 mM KCl 25.0 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 5.0, 4.0, 5.0, 6.0, 2.0, 1.0, 4.0, 6.0, 5.0 1L63, 2LZM 27.231428827558243, 47.70777829488119, 42.93500010172526, 53.960000446864534, 31.671667098999023, 53.328750133514404, 27.80999978383382, 24.191111034817165, 21.792500019073486, 19.5099999109904, 25.431428909301758, 32.621110916137695, 36.1050001780192, 37.090000425066265, 32.44999980926514, 40.831249952316284, 29.99500020345052, 21.3122222688463, 27.502500295639038, 17.67888895670573 in tunnel in pocket 12487988 10.1016/s0301-4622(02)00193-x 2002 ProTherm 15796 7402 164 T34A, K35A, S36A, P37A, S38A, N40D, S44A, E45A, D47A, K48A Endolysin Enterobacteria phage T4 1.8 -9.7 yes(>90%) 42.0 KPO4 20.0 mM KCl 25.0 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 5.0, 4.0, 5.0, 6.0, 2.0, 1.0, 4.0, 6.0, 5.0 1L63, 2LZM 27.231428827558243, 47.70777829488119, 42.93500010172526, 53.960000446864534, 31.671667098999023, 53.328750133514404, 27.80999978383382, 24.191111034817165, 21.792500019073486, 19.5099999109904, 25.431428909301758, 32.621110916137695, 36.1050001780192, 37.090000425066265, 32.44999980926514, 40.831249952316284, 29.99500020345052, 21.3122222688463, 27.502500295639038, 17.67888895670573 in tunnel in pocket 12487988 10.1016/s0301-4622(02)00193-x 2002 ProTherm 15802 7408 164 T34A, K35A, S36A, P37A, E128A, V131A, N132A Endolysin Enterobacteria phage T4 1.8 97.0 0.5 yes(>90%) 52.9 KPO4 20.0 mM KCl 25.0 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 7.0, 5.0, 4.0, 5.0, 1.0, 2.0, 6.0 1L63, 2LZM 27.231428827558243, 47.70777829488119, 42.93500010172526, 53.960000446864534, 46.15444416469998, 22.488571166992188, 18.553750157356262, 25.431428909301758, 32.621110916137695, 36.1050001780192, 37.090000425066265, 30.945555051167805, 16.635714530944824, 16.804999947547913 in tunnel in pocket 12487988 10.1016/s0301-4622(02)00193-x 2002 ProTherm 16785 7408 164 T34A, K35A, S36A, P37A, E128A, V131A, N132A Endolysin Enterobacteria phage T4 1.8 0.2 yes KPO4 20.0 mM 53.4 KCl 25.0 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 7.0, 5.0, 4.0, 5.0, 1.0, 2.0, 6.0 1L63, 2LZM 27.231428827558243, 47.70777829488119, 42.93500010172526, 53.960000446864534, 46.15444416469998, 22.488571166992188, 18.553750157356262, 25.431428909301758, 32.621110916137695, 36.1050001780192, 37.090000425066265, 30.945555051167805, 16.635714530944824, 16.804999947547913 in tunnel in pocket 12487988 10.1016/s0301-4622(02)00193-x 2002 ProTherm 2996 1598 164 P37A Endolysin Enterobacteria phage T4 -0.8 yes 41.1 phosphate 50 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 53.960000446864534, 37.090000425066265 in pocket 7074100 10.1021/bi00535a054 1982 ProTherm AUTOMUTE_S1962.csv, guerios_625_map.csv, potapov_with_uniprot_mapping.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4654 1598 164 P37A Endolysin Enterobacteria phage T4 -0.8 yes 2.0 41.1 Phosphate buffer 50 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 53.960000446864534, 37.090000425066265 in pocket 1737005 10.1021/bi00120a025 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 12604 1598 164 P37A Endolysin Enterobacteria phage T4 6.3 0.0 Unknown imidazole,MOPS, 0.05 M,0.05 M, 22.0 Gel electrophoresis Urea 7.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 53.960000446864534, 37.090000425066265 in pocket 1988046 10.1021/bi00216a038 1991 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv 13899 1598 164 P37A Endolysin Enterobacteria phage T4 2.93 17.9 yes 2.0 Phosphate buffer 50 mM 12.0 CD GdnHCl 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 53.960000446864534, 37.090000425066265 in pocket 1737005 10.1021/bi00120a025 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv 818 503 164 S38N Endolysin Enterobacteria phage T4 -0.3 yes 39.2 HCl 0.01 N KCl 200 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 31.671667098999023, 32.44999980926514 1911773 10.1021/bi00105a002 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 823 503 164 S38N Endolysin Enterobacteria phage T4 -0.1 yes 62.3 HCl 0.01 N KCl 200 mM CD Thermal 6.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 31.671667098999023, 32.44999980926514 1911773 10.1021/bi00105a002 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7062 503 164 S38N Endolysin Enterobacteria phage T4 0.0 yes HCl 0.01 N 62.4 KCl 200 mM CD Thermal 6.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 31.671667098999023, 32.44999980926514 1911773 10.1021/bi00105a002 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8157 503 164 S38N Endolysin Enterobacteria phage T4 0.1 yes HCl 0.01 N 39.5 KCl 200 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 31.671667098999023, 32.44999980926514 1911773 10.1021/bi00105a002 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 899 527 164 S38D Endolysin Enterobacteria phage T4 1.8 123.0 0.46 Unknown 53.88 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 31.671667098999023, 32.44999980926514 8771182 10.1093/protein/8.10.1017 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 906 527 164 S38D Endolysin Enterobacteria phage T4 2.5 140.0 1.36 Unknown 67.87 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 31.671667098999023, 32.44999980926514 8771182 10.1093/protein/8.10.1017 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3294 527 164 S38D Endolysin Enterobacteria phage T4 -0.3 yes 40.6 HCl 0.01 N KCl 200 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 31.671667098999023, 32.44999980926514 1911773 10.1021/bi00105a002 1991 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3299 527 164 S38D Endolysin Enterobacteria phage T4 1.5 yes 67.6 phosphate 10 mM KCl 150 mM CD Thermal 6.9 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 31.671667098999023, 32.44999980926514 1911773 10.1021/bi00105a002 1991 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6721 527 164 S38D Endolysin Enterobacteria phage T4 2.5 -0.6 Unknown Acetic acid, Sodium acetate 1.4 mM, 8.6 mM 66.51 NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 31.671667098999023, 32.44999980926514 8771182 10.1093/protein/8.10.1017 1995 ProTherm capriotti_S1615_map.csv 6749 527 164 S38D Endolysin Enterobacteria phage T4 -0.6 yes phosphate 10 mM 66.1 KCl 150 mM CD Thermal 6.9 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 31.671667098999023, 32.44999980926514 1911773 10.1021/bi00105a002 1991 ProTherm capriotti_S1615_map.csv 7336 527 164 S38D Endolysin Enterobacteria phage T4 1.8 -0.22 Unknown KH2PO4, H3PO4 17 mM, 3 mM 53.42 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 31.671667098999023, 32.44999980926514 8771182 10.1093/protein/8.10.1017 1995 ProTherm capriotti_S1615_map.csv 8063 527 164 S38D Endolysin Enterobacteria phage T4 0.1 yes HCl 0.01 N 40.9 KCl 200 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 31.671667098999023, 32.44999980926514 1911773 10.1021/bi00105a002 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 12605 527 164 S38D Endolysin Enterobacteria phage T4 5.6 1.2 Unknown imidazole,MOPS, 0.05 M,0.05 M, 22.0 Gel electrophoresis Urea 7.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 31.671667098999023, 32.44999980926514 1988046 10.1021/bi00216a038 1991 ProTherm SAAFEC_S1262.csv 1603 902 164 S38A Endolysin Enterobacteria phage T4 1.8 118.0 -1.95 yes(>90%) 51.45 KPO4 20.0 mM KCl 25.0 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 31.671667098999023, 32.44999980926514 12487988 10.1016/s0301-4622(02)00193-x 2002 ProTherm 7348 902 164 S38A Endolysin Enterobacteria phage T4 1.8 0.77 yes(>90%) KPO4 20.0 mM 53.4 KCl 25.0 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 31.671667098999023, 32.44999980926514 12487988 10.1016/s0301-4622(02)00193-x 2002 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14558 6772 164 S38D, N144D Endolysin Enterobacteria phage T4 1.8 119.0 1.35 Unknown 54.77 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0, 6.0 1L63, 2LZM 31.671667098999023, 21.59874975681305, 32.44999980926514, 17.32000035047531 8771182 10.1093/protein/8.10.1017 1995 ProTherm 14565 6772 164 S38D, N144D Endolysin Enterobacteria phage T4 2.5 136.0 2.36 Unknown 68.87 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0, 6.0 1L63, 2LZM 31.671667098999023, 21.59874975681305, 32.44999980926514, 17.32000035047531 8771182 10.1093/protein/8.10.1017 1995 ProTherm 14896 6772 164 S38D, N144D Endolysin Enterobacteria phage T4 2.5 -1.03 Unknown Acetic acid, Sodium acetate 1.4 mM, 8.6 mM 66.51 NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0, 6.0 1L63, 2LZM 31.671667098999023, 21.59874975681305, 32.44999980926514, 17.32000035047531 8771182 10.1093/protein/8.10.1017 1995 ProTherm 14977 6772 164 S38D, N144D Endolysin Enterobacteria phage T4 1.8 -0.6 Unknown KH2PO4, H3PO4 17 mM, 3 mM 53.42 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0, 6.0 1L63, 2LZM 31.671667098999023, 21.59874975681305, 32.44999980926514, 17.32000035047531 8771182 10.1093/protein/8.10.1017 1995 ProTherm 14559 6773 164 S38D, A82P, N144D Endolysin Enterobacteria phage T4 1.8 123.0 2.58 Unknown 56.0 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0, 4.0, 6.0 1L63, 2LZM 31.671667098999023, 26.978000259399415, 21.59874975681305, 32.44999980926514, 23.790000343322752, 17.32000035047531 8771182 10.1093/protein/8.10.1017 1995 ProTherm 14566 6773 164 S38D, A82P, N144D Endolysin Enterobacteria phage T4 2.5 138.0 3.75 Unknown 70.26 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0, 4.0, 6.0 1L63, 2LZM 31.671667098999023, 26.978000259399415, 21.59874975681305, 32.44999980926514, 23.790000343322752, 17.32000035047531 8771182 10.1093/protein/8.10.1017 1995 ProTherm 14897 6773 164 S38D, A82P, N144D Endolysin Enterobacteria phage T4 2.5 -1.59 Unknown Acetic acid, Sodium acetate 1.4 mM, 8.6 mM 66.51 NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0, 4.0, 6.0 1L63, 2LZM 31.671667098999023, 26.978000259399415, 21.59874975681305, 32.44999980926514, 23.790000343322752, 17.32000035047531 8771182 10.1093/protein/8.10.1017 1995 ProTherm 14978 6773 164 S38D, A82P, N144D Endolysin Enterobacteria phage T4 1.8 -1.05 Unknown KH2PO4, H3PO4 17 mM, 3 mM 53.42 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0, 4.0, 6.0 1L63, 2LZM 31.671667098999023, 26.978000259399415, 21.59874975681305, 32.44999980926514, 23.790000343322752, 17.32000035047531 8771182 10.1093/protein/8.10.1017 1995 ProTherm 2921 1541 164 L39A Endolysin Enterobacteria phage T4 127.0 -2.5 Unknown 62.7 Sodium acetate 0.01 M NaCl 0.1 M CD Thermal 5.45 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 28.554999589920044, 30.899999618530273 8114100 10.1006/jmbi.1994.1195 1994 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7413 1541 164 L39A Endolysin Enterobacteria phage T4 4.5 0.9 Unknown Sodium acetate 0.01 M 53.0 NaCl 0.1 M CD Thermal 5.45 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 28.554999589920044, 30.899999618530273 8114100 10.1006/jmbi.1994.1195 1994 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 2998 1599 164 L39P Endolysin Enterobacteria phage T4 -5.5 yes 36.4 phosphate 50 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 28.554999589920044, 30.899999618530273 7074100 10.1021/bi00535a054 1982 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4655 1599 164 L39P Endolysin Enterobacteria phage T4 -5.5 yes 2.0 36.4 Phosphate buffer 50 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 28.554999589920044, 30.899999618530273 1737005 10.1021/bi00120a025 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 13900 1599 164 L39P Endolysin Enterobacteria phage T4 2.87 15.4 yes 2.0 Phosphate buffer 50 mM 12.0 CD GdnHCl 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 28.554999589920044, 30.899999618530273 1737005 10.1021/bi00120a025 1992 ProTherm 147 88 164 N40A Endolysin Enterobacteria phage T4 117.0 1.2 yes 52.75 H3PO4,KH2PO4, 3 mM,17 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 53.328750133514404, 40.831249952316284 in pocket 1570293 10.1073/pnas.89.9.3751 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 154 88 164 N40A Endolysin Enterobacteria phage T4 125.0 0.88 yes 63.08 KH2PO4 0.01 M KCl 0.15 M CD Thermal 6.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 53.328750133514404, 40.831249952316284 in pocket 1570293 10.1073/pnas.89.9.3751 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 2922 88 164 N40A Endolysin Enterobacteria phage T4 135.0 0.9 Unknown 66.1 Sodium acetate 0.01 M NaCl 0.1 M CD Thermal 5.45 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 53.328750133514404, 40.831249952316284 in pocket 8114100 10.1006/jmbi.1994.1195 1994 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, EASE-MM_S543.csv, PoPMuSiC-2.0_S2648.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7067 88 164 N40A Endolysin Enterobacteria phage T4 -0.32 yes KH2PO4 0.01 M 62.2 KCl 0.15 M CD Thermal 6.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 53.328750133514404, 40.831249952316284 in pocket 1570293 10.1073/pnas.89.9.3751 1992 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, potapov_with_uniprot_mapping.csv 7414 88 164 N40A Endolysin Enterobacteria phage T4 4.5 -0.2 Unknown Sodium acetate 0.01 M 53.0 NaCl 0.1 M CD Thermal 5.45 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 53.328750133514404, 40.831249952316284 in pocket 8114100 10.1006/jmbi.1994.1195 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 7542 88 164 N40A Endolysin Enterobacteria phage T4 -0.43 yes H3PO4,KH2PO4 3 mM,17 mM 51.65 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 53.328750133514404, 40.831249952316284 in pocket 1570293 10.1073/pnas.89.9.3751 1992 ProTherm capriotti_S1615_map.csv 192 98 164 N40D Endolysin Enterobacteria phage T4 3.5 132.0 1.14 Unknown 66.29 Sodium acetate 10 mM NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 53.328750133514404, 40.831249952316284 in pocket 7507755 10.1002/pro.5560021221 1993 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, HotMuSiC_S1626.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 204 98 164 N40D Endolysin Enterobacteria phage T4 3.5 1.28 Unknown 63.47 Potassium phosphate 0.01 M KCl 0.15 M CD Thermal 6.78 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 53.328750133514404, 40.831249952316284 in pocket 7507755 10.1002/pro.5560021221 1993 ProTherm HotMuSiC_S1626.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6821 98 164 N40D Endolysin Enterobacteria phage T4 3.5 -0.44 Unknown Sodium acetate 10 mM 65.15 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 53.328750133514404, 40.831249952316284 in pocket 7507755 10.1002/pro.5560021221 1993 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 15789 7395 164 N40A, S44A, E45A, D47A, K48A, D127A, E128A, V131A, N132A Endolysin Enterobacteria phage T4 1.8 117.0 5.2 yes(>90%) 56.9 KPO4 20.0 mM KCl 25.0 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 2.0, 1.0, 4.0, 6.0, 5.0, 1.0, 1.0, 2.0, 6.0 1L63, 2LZM 53.328750133514404, 27.80999978383382, 24.191111034817165, 21.792500019073486, 19.5099999109904, 25.588749885559082, 46.15444416469998, 22.488571166992188, 18.553750157356262, 40.831249952316284, 29.99500020345052, 21.3122222688463, 27.502500295639038, 17.67888895670573, 25.15374982357025, 30.945555051167805, 16.635714530944824, 16.804999947547913 in tunnel in pocket 12487988 10.1016/s0301-4622(02)00193-x 2002 ProTherm 16786 7395 164 N40A, S44A, E45A, D47A, K48A, D127A, E128A, V131A, N132A Endolysin Enterobacteria phage T4 1.8 -1.75 yes(>90%) KPO4 20.0 mM 51.7 KCl 25.0 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 2.0, 1.0, 4.0, 6.0, 5.0, 1.0, 1.0, 2.0, 6.0 1L63, 2LZM 53.328750133514404, 27.80999978383382, 24.191111034817165, 21.792500019073486, 19.5099999109904, 25.588749885559082, 46.15444416469998, 22.488571166992188, 18.553750157356262, 40.831249952316284, 29.99500020345052, 21.3122222688463, 27.502500295639038, 17.67888895670573, 25.15374982357025, 30.945555051167805, 16.635714530944824, 16.804999947547913 in tunnel in pocket 12487988 10.1016/s0301-4622(02)00193-x 2002 ProTherm 193 99 164 A41D Endolysin Enterobacteria phage T4 3.5 138.0 0.71 Unknown 65.86 Sodium acetate 10 mM NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 27.43000030517578, 28.104000091552734 7507755 10.1002/pro.5560021221 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 205 99 164 A41D Endolysin Enterobacteria phage T4 3.5 1.1 Unknown 63.29 Potassium phosphate 0.01 M KCl 0.15 M CD Thermal 6.78 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 27.43000030517578, 28.104000091552734 7507755 10.1002/pro.5560021221 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6822 99 164 A41D Endolysin Enterobacteria phage T4 3.5 -0.29 Unknown Sodium acetate 10 mM 65.15 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 27.43000030517578, 28.104000091552734 7507755 10.1002/pro.5560021221 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 415 229 164 A41S Endolysin Enterobacteria phage T4 106.0 -1.77 yes 49.78 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 27.43000030517578, 28.104000091552734 8218201 10.1021/bi00093a013 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7584 229 164 A41S Endolysin Enterobacteria phage T4 0.6 yes Potassium phosphate 20 mM 51.55 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 27.43000030517578, 28.104000091552734 8218201 10.1021/bi00093a013 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 904 529 164 A41V Endolysin Enterobacteria phage T4 1.8 132.0 1.1 Unknown 54.52 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 27.43000030517578, 28.104000091552734 8771182 10.1093/protein/8.10.1017 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 911 529 164 A41V Endolysin Enterobacteria phage T4 2.5 141.0 0.7 Unknown 67.21 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 27.43000030517578, 28.104000091552734 8771182 10.1093/protein/8.10.1017 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 995 529 164 A41V Endolysin Enterobacteria phage T4 83.3 1.6 Unknown 43.07 Unknown KCl 0.2 M CD Thermal 2.03 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 27.43000030517578, 28.104000091552734 2326253 10.1002/prot.340070208 1990 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 998 529 164 A41V Endolysin Enterobacteria phage T4 109.7 1.33 Unknown 52.43 Unknown KCl 0.2 M CD Thermal 2.83 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 27.43000030517578, 28.104000091552734 2326253 10.1002/prot.340070208 1990 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6726 529 164 A41V Endolysin Enterobacteria phage T4 2.5 -0.3 Unknown Acetic acid, Sodium acetate 1.4 mM, 8.6 mM 66.51 NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 27.43000030517578, 28.104000091552734 8771182 10.1093/protein/8.10.1017 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 7341 529 164 A41V Endolysin Enterobacteria phage T4 1.8 -0.41 Unknown KH2PO4, H3PO4 17 mM, 3 mM 53.42 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 27.43000030517578, 28.104000091552734 8771182 10.1093/protein/8.10.1017 1995 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 7613 529 164 A41V Endolysin Enterobacteria phage T4 -0.45 Unknown K2HPO4, NaH2PO4 1.05 M, 1.26 M 51.1 KCl 0.2 M CD Thermal 2.83 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 27.43000030517578, 28.104000091552734 2326253 10.1002/prot.340070208 1990 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 8054 529 164 A41V Endolysin Enterobacteria phage T4 -0.42 Unknown K2HPO4, NaH2PO4 1.05 M, 1.26 M 41.47 KCl 0.2 M CD Thermal 2.03 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 27.43000030517578, 28.104000091552734 2326253 10.1002/prot.340070208 1990 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 14557 6771 164 V131A, A41V Endolysin Enterobacteria phage T4 1.8 123.0 1.83 Unknown 55.25 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 2.0 1L63, 2LZM 27.43000030517578, 22.488571166992188, 28.104000091552734, 16.635714530944824 in pocket 8771182 10.1093/protein/8.10.1017 1995 ProTherm 14564 6771 164 V131A, A41V Endolysin Enterobacteria phage T4 2.5 140.0 1.51 Unknown 68.02 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 2.0 1L63, 2LZM 27.43000030517578, 22.488571166992188, 28.104000091552734, 16.635714530944824 in pocket 8771182 10.1093/protein/8.10.1017 1995 ProTherm 14580 6771 164 V131A, A41V Endolysin Enterobacteria phage T4 80.3 2.2 Unknown 43.67 Unknown KCl 0.2 M CD Thermal 2.03 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 2.0 1L63, 2LZM 27.43000030517578, 22.488571166992188, 28.104000091552734, 16.635714530944824 in pocket 2326253 10.1002/prot.340070208 1990 ProTherm 14581 6771 164 V131A, A41V Endolysin Enterobacteria phage T4 107.3 1.81 Unknown 52.91 Unknown KCl 0.2 M CD Thermal 2.83 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 2.0 1L63, 2LZM 27.43000030517578, 22.488571166992188, 28.104000091552734, 16.635714530944824 in pocket 2326253 10.1002/prot.340070208 1990 ProTherm 14895 6771 164 V131A, A41V Endolysin Enterobacteria phage T4 2.5 -0.66 Unknown Acetic acid, Sodium acetate 1.4 mM, 8.6 mM 66.51 NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 2.0 1L63, 2LZM 27.43000030517578, 22.488571166992188, 28.104000091552734, 16.635714530944824 in pocket 8771182 10.1093/protein/8.10.1017 1995 ProTherm 14976 6771 164 V131A, A41V Endolysin Enterobacteria phage T4 1.8 -0.76 Unknown KH2PO4, H3PO4 17 mM, 3 mM 53.42 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 2.0 1L63, 2LZM 27.43000030517578, 22.488571166992188, 28.104000091552734, 16.635714530944824 in pocket 8771182 10.1093/protein/8.10.1017 1995 ProTherm 15032 6771 164 V131A, A41V Endolysin Enterobacteria phage T4 -0.6 Unknown K2HPO4, NaH2PO4 1.05 M, 1.26 M 51.1 KCl 0.2 M CD Thermal 2.83 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 2.0 1L63, 2LZM 27.43000030517578, 22.488571166992188, 28.104000091552734, 16.635714530944824 in pocket 2326253 10.1002/prot.340070208 1990 ProTherm 15097 6771 164 V131A, A41V Endolysin Enterobacteria phage T4 -0.56 Unknown K2HPO4, NaH2PO4 1.05 M, 1.26 M 41.47 KCl 0.2 M CD Thermal 2.03 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 2.0 1L63, 2LZM 27.43000030517578, 22.488571166992188, 28.104000091552734, 16.635714530944824 in pocket 2326253 10.1002/prot.340070208 1990 ProTherm 416 230 164 A42S Endolysin Enterobacteria phage T4 89.0 -7.49 yes 44.06 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 24.499999618530275, 27.297999954223634 8218201 10.1021/bi00093a013 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7585 230 164 A42S Endolysin Enterobacteria phage T4 2.3 yes Potassium phosphate 20 mM 51.55 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 24.499999618530275, 27.297999954223634 8218201 10.1021/bi00093a013 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 2923 1542 164 A42K Endolysin Enterobacteria phage T4 64.0 -11.0 Unknown 54.2 Sodium acetate 0.01 M NaCl 0.1 M CD Thermal 5.45 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 24.499999618530275, 27.297999954223634 8114100 10.1006/jmbi.1994.1195 1994 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4064 1542 164 A42K Endolysin Enterobacteria phage T4 71.94 -15.3 yes 38.8 glycine-HCl 20 mM DSC Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 24.499999618530275, 27.297999954223634 8889173 10.1016/S0006-3495(96)79397-9 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4065 1542 164 A42K Endolysin Enterobacteria phage T4 79.11 yes 43.1 glycine-HCl 20 mM DSC Thermal 3.2 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 24.499999618530275, 27.297999954223634 8889173 10.1016/S0006-3495(96)79397-9 1996 ProTherm 4066 1542 164 A42K Endolysin Enterobacteria phage T4 84.61 -14.5 yes 44.9 glycine-HCl 20 mM DSC Thermal 3.3 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 24.499999618530275, 27.297999954223634 8889173 10.1016/S0006-3495(96)79397-9 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4067 1542 164 A42K Endolysin Enterobacteria phage T4 91.54 -14.2 yes 47.9 glycine-HCl 20 mM DSC Thermal 3.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 24.499999618530275, 27.297999954223634 8889173 10.1016/S0006-3495(96)79397-9 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4068 1542 164 A42K Endolysin Enterobacteria phage T4 88.91 yes 50.1 glycine-HCl 20 mM DSC Thermal 3.6 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 24.499999618530275, 27.297999954223634 8889173 10.1016/S0006-3495(96)79397-9 1996 ProTherm 4069 1542 164 A42K Endolysin Enterobacteria phage T4 97.75 -13.2 yes 51.4 glycine-HCl 20 mM DSC Thermal 3.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 24.499999618530275, 27.297999954223634 8889173 10.1016/S0006-3495(96)79397-9 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4070 1542 164 A42K Endolysin Enterobacteria phage T4 105.16 yes 54.4 glycine-HCl 20 mM DSC Thermal 4.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 24.499999618530275, 27.297999954223634 8889173 10.1016/S0006-3495(96)79397-9 1996 ProTherm 7415 1542 164 A42K Endolysin Enterobacteria phage T4 4.5 3.7 Unknown Sodium acetate 0.01 M 53.0 NaCl 0.1 M CD Thermal 5.45 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 24.499999618530275, 27.297999954223634 8114100 10.1006/jmbi.1994.1195 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3773 1956 164 A42V Endolysin Enterobacteria phage T4 79.0 -7.5 yes 44.2 phosphoric acid,Potassium phosphate, 3 mM,17 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 24.499999618530275, 27.297999954223634 10623513 10.1006/jmbi.1999.3300 2000 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, EASE-MM_S543.csv, PoPMuSiC-2.0_S2648.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3774 1957 164 A42L Endolysin Enterobacteria phage T4 56.0 -10.1 yes 41.6 phosphoric acid,Potassium phosphate, 3 mM,17 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 24.499999618530275, 27.297999954223634 10623513 10.1006/jmbi.1999.3300 2000 ProTherm AUTOMUTE_S1962.csv, EASE-MM_S543.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3775 1958 164 A42I Endolysin Enterobacteria phage T4 67.0 -8.9 yes 42.8 phosphoric acid,Potassium phosphate, 3 mM,17 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 24.499999618530275, 27.297999954223634 10623513 10.1006/jmbi.1999.3300 2000 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q306.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3776 1959 164 A42F Endolysin Enterobacteria phage T4 56.0 -11.2 yes 40.5 phosphoric acid,Potassium phosphate, 3 mM,17 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 24.499999618530275, 27.297999954223634 10623513 10.1006/jmbi.1999.3300 2000 ProTherm EASE-MM_S543.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv, AUTOMUTE_S1962.csv, Saraboji_S2204.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 10021 4335 164 A42G Endolysin Enterobacteria phage T4 3.2 11.7 2.6 Unknown Potassium phosphate 20 mM 25.0 NaCl 100 mM CD Urea 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 24.499999618530275, 27.297999954223634 17400925 10.1110/ps.062632807 2007 ProTherm SAAFEC_S1262.csv 148 89 164 K43A Endolysin Enterobacteria phage T4 101.0 -2.95 yes 48.7 H3PO4,KH2PO4, 3 mM,17 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 41.36333317226834, 33.79777823554145 in pocket 1570293 10.1073/pnas.89.9.3751 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 155 89 164 K43A Endolysin Enterobacteria phage T4 108.0 -3.08 yes 59.12 KH2PO4 0.01 M KCl 0.15 M CD Thermal 6.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 41.36333317226834, 33.79777823554145 in pocket 1570293 10.1073/pnas.89.9.3751 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 2924 89 164 K43A Endolysin Enterobacteria phage T4 124.0 -3.1 Unknown 62.1 Sodium acetate 0.01 M NaCl 0.1 M CD Thermal 5.45 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 41.36333317226834, 33.79777823554145 in pocket 8114100 10.1006/jmbi.1994.1195 1994 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7068 89 164 K43A Endolysin Enterobacteria phage T4 1.03 yes KH2PO4 0.01 M 62.2 KCl 0.15 M CD Thermal 6.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 41.36333317226834, 33.79777823554145 in pocket 1570293 10.1073/pnas.89.9.3751 1992 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, potapov_with_uniprot_mapping.csv 7416 89 164 K43A Endolysin Enterobacteria phage T4 4.5 1.1 Unknown Sodium acetate 0.01 M 53.0 NaCl 0.1 M CD Thermal 5.45 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 41.36333317226834, 33.79777823554145 in pocket 8114100 10.1006/jmbi.1994.1195 1994 ProTherm capriotti_S1615_map.csv 7543 89 164 K43A Endolysin Enterobacteria phage T4 0.96 yes H3PO4,KH2PO4 3 mM,17 mM 51.65 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 41.36333317226834, 33.79777823554145 in pocket 1570293 10.1073/pnas.89.9.3751 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 149 90 164 S44A Endolysin Enterobacteria phage T4 122.0 1.2 yes 52.75 H3PO4,KH2PO4, 3 mM,17 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 1570293 10.1073/pnas.89.9.3751 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 156 90 164 S44A Endolysin Enterobacteria phage T4 119.0 0.98 yes 63.18 KH2PO4 0.01 M KCl 0.15 M CD Thermal 6.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 1570293 10.1073/pnas.89.9.3751 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 930 90 164 S44A Endolysin Enterobacteria phage T4 117.0 1.21 yes 52.89 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3545 90 164 S44A Endolysin Enterobacteria phage T4 -1.6 Unknown 49.4 Potassium phosphate 20 mM KCl 25 mM CD Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 7918421 10.1021/bi00206a003 1994 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4058 90 164 S44A Endolysin Enterobacteria phage T4 72.18 -15.7 yes 38.4 glycine-HCl 20 mM DSC Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8889173 10.1016/S0006-3495(96)79397-9 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4059 90 164 S44A Endolysin Enterobacteria phage T4 89.15 yes 44.1 glycine-HCl 20 mM DSC Thermal 3.2 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8889173 10.1016/S0006-3495(96)79397-9 1996 ProTherm 4060 90 164 S44A Endolysin Enterobacteria phage T4 89.87 -14.3 yes 45.1 glycine-HCl 20 mM DSC Thermal 3.3 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8889173 10.1016/S0006-3495(96)79397-9 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4061 90 164 S44A Endolysin Enterobacteria phage T4 95.6 yes 49.8 glycine-HCl 20 mM DSC Thermal 3.6 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8889173 10.1016/S0006-3495(96)79397-9 1996 ProTherm 4062 90 164 S44A Endolysin Enterobacteria phage T4 90.46 -13.7 yes 50.9 glycine-HCl 20 mM DSC Thermal 3.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8889173 10.1016/S0006-3495(96)79397-9 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4063 90 164 S44A Endolysin Enterobacteria phage T4 105.64 yes 54.3 glycine-HCl 20 mM DSC Thermal 4.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8889173 10.1016/S0006-3495(96)79397-9 1996 ProTherm 7069 90 164 S44A Endolysin Enterobacteria phage T4 -0.34 yes KH2PO4 0.01 M 62.2 KCl 0.15 M CD Thermal 6.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 1570293 10.1073/pnas.89.9.3751 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 7523 90 164 S44A Endolysin Enterobacteria phage T4 2.4 -0.43 yes KH2PO4, H3PO4 17 mM, 3 mM 51.68 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm capriotti_S1615_map.csv 7544 90 164 S44A Endolysin Enterobacteria phage T4 -0.44 yes H3PO4,KH2PO4 3 mM,17 mM 51.65 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 1570293 10.1073/pnas.89.9.3751 1992 ProTherm capriotti_S1615_map.csv 7785 90 164 S44A Endolysin Enterobacteria phage T4 0.44 Unknown Potassium phosphate 20 mM 47.8 KCl 25 mM CD Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 7918421 10.1021/bi00206a003 1994 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv 931 547 164 S44L Endolysin Enterobacteria phage T4 117.0 1.09 yes 52.77 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7524 547 164 S44L Endolysin Enterobacteria phage T4 2.4 -0.39 yes KH2PO4, H3PO4 17 mM, 3 mM 51.68 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 932 548 164 S44M Endolysin Enterobacteria phage T4 115.0 0.92 yes 52.6 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7525 548 164 S44M Endolysin Enterobacteria phage T4 2.4 -0.33 yes KH2PO4, H3PO4 17 mM, 3 mM 51.68 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 933 549 164 S44I Endolysin Enterobacteria phage T4 112.0 0.91 yes 52.59 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7526 549 164 S44I Endolysin Enterobacteria phage T4 2.4 -0.31 yes KH2PO4, H3PO4 17 mM, 3 mM 51.68 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 934 550 164 S44Q Endolysin Enterobacteria phage T4 116.0 0.75 yes 52.43 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7527 550 164 S44Q Endolysin Enterobacteria phage T4 2.4 -0.27 yes KH2PO4, H3PO4 17 mM, 3 mM 51.68 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 935 551 164 S44R Endolysin Enterobacteria phage T4 116.0 0.68 yes 52.36 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7528 551 164 S44R Endolysin Enterobacteria phage T4 2.4 -0.24 yes KH2PO4, H3PO4 17 mM, 3 mM 51.68 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 936 552 164 S44K Endolysin Enterobacteria phage T4 116.0 0.57 yes 52.25 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7529 552 164 S44K Endolysin Enterobacteria phage T4 2.4 -0.2 yes KH2PO4, H3PO4 17 mM, 3 mM 51.68 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 937 553 164 S44Y Endolysin Enterobacteria phage T4 115.0 0.54 yes 52.22 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7530 553 164 S44Y Endolysin Enterobacteria phage T4 2.4 -0.19 yes KH2PO4, H3PO4 17 mM, 3 mM 51.68 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 938 554 164 S44V Endolysin Enterobacteria phage T4 113.0 0.29 yes 51.97 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7531 554 164 S44V Endolysin Enterobacteria phage T4 2.4 -0.1 yes KH2PO4, H3PO4 17 mM, 3 mM 51.68 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 939 555 164 S44F Endolysin Enterobacteria phage T4 116.0 0.18 yes 51.86 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7532 555 164 S44F Endolysin Enterobacteria phage T4 2.4 -0.06 yes KH2PO4, H3PO4 17 mM, 3 mM 51.68 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 940 556 164 S44W Endolysin Enterobacteria phage T4 112.0 0.15 yes 51.83 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7533 556 164 S44W Endolysin Enterobacteria phage T4 2.4 -0.05 yes KH2PO4, H3PO4 17 mM, 3 mM 51.68 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 941 557 164 S44H Endolysin Enterobacteria phage T4 117.0 0.12 yes 51.8 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7534 557 164 S44H Endolysin Enterobacteria phage T4 2.4 -0.04 yes KH2PO4, H3PO4 17 mM, 3 mM 51.68 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 942 558 164 S44T Endolysin Enterobacteria phage T4 113.0 0.03 yes 51.71 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7535 558 164 S44T Endolysin Enterobacteria phage T4 2.4 -0.01 yes KH2PO4, H3PO4 17 mM, 3 mM 51.68 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 943 559 164 S44E Endolysin Enterobacteria phage T4 111.0 0.0 yes 51.68 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7536 559 164 S44E Endolysin Enterobacteria phage T4 2.4 0.0 yes KH2PO4, H3PO4 17 mM, 3 mM 51.68 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 944 560 164 S44D Endolysin Enterobacteria phage T4 110.0 -0.32 yes 51.36 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7537 560 164 S44D Endolysin Enterobacteria phage T4 2.4 0.11 yes KH2PO4, H3PO4 17 mM, 3 mM 51.68 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 945 561 164 S44C Endolysin Enterobacteria phage T4 117.0 -0.35 yes 51.33 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7538 561 164 S44C Endolysin Enterobacteria phage T4 2.4 0.11 yes KH2PO4, H3PO4 17 mM, 3 mM 51.68 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 946 562 164 S44N Endolysin Enterobacteria phage T4 110.0 -0.4 yes 51.28 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7539 562 164 S44N Endolysin Enterobacteria phage T4 2.4 0.14 yes KH2PO4, H3PO4 17 mM, 3 mM 51.68 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 947 563 164 S44G Endolysin Enterobacteria phage T4 110.0 -1.55 yes 50.13 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7540 563 164 S44G Endolysin Enterobacteria phage T4 2.4 0.53 yes KH2PO4, H3PO4 17 mM, 3 mM 51.68 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 948 564 164 S44P Endolysin Enterobacteria phage T4 74.0 -10.32 yes 41.36 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7541 564 164 S44P Endolysin Enterobacteria phage T4 2.4 3.03 yes KH2PO4, H3PO4 17 mM, 3 mM 51.68 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 27.80999978383382, 29.99500020345052 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 150 91 164 E45A Endolysin Enterobacteria phage T4 125.0 1.47 yes 53.12 H3PO4,KH2PO4, 3 mM,17 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 24.191111034817165, 21.3122222688463 in tunnel 1570293 10.1073/pnas.89.9.3751 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 157 91 164 E45A Endolysin Enterobacteria phage T4 124.0 0.04 yes 62.24 KH2PO4 0.01 M KCl 0.15 M CD Thermal 6.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 24.191111034817165, 21.3122222688463 in tunnel 1570293 10.1073/pnas.89.9.3751 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7070 91 164 E45A Endolysin Enterobacteria phage T4 -0.01 yes KH2PO4 0.01 M 62.2 KCl 0.15 M CD Thermal 6.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 24.191111034817165, 21.3122222688463 in tunnel 1570293 10.1073/pnas.89.9.3751 1992 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 7545 91 164 E45A Endolysin Enterobacteria phage T4 -0.55 yes H3PO4,KH2PO4 3 mM,17 mM 51.65 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 24.191111034817165, 21.3122222688463 in tunnel 1570293 10.1073/pnas.89.9.3751 1992 ProTherm capriotti_S1615_map.csv 14457 6708 164 E45A, K48A Endolysin Enterobacteria phage T4 121.0 1.04 yes 52.69 H3PO4,KH2PO4, 3 mM,17 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 5.0 1L63, 2LZM 24.191111034817165, 19.5099999109904, 21.3122222688463, 17.67888895670573 in tunnel 1570293 10.1073/pnas.89.9.3751 1992 ProTherm 14458 6708 164 E45A, K48A Endolysin Enterobacteria phage T4 127.0 0.03 yes 62.23 KH2PO4 0.01 M KCl 0.15 M CD Thermal 6.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 5.0 1L63, 2LZM 24.191111034817165, 19.5099999109904, 21.3122222688463, 17.67888895670573 in tunnel 1570293 10.1073/pnas.89.9.3751 1992 ProTherm 14949 6708 164 E45A, K48A Endolysin Enterobacteria phage T4 -0.01 yes KH2PO4 0.01 M 62.2 KCl 0.15 M CD Thermal 6.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 5.0 1L63, 2LZM 24.191111034817165, 19.5099999109904, 21.3122222688463, 17.67888895670573 in tunnel 1570293 10.1073/pnas.89.9.3751 1992 ProTherm 15019 6708 164 E45A, K48A Endolysin Enterobacteria phage T4 -0.38 yes H3PO4,KH2PO4 3 mM,17 mM 51.65 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 5.0 1L63, 2LZM 24.191111034817165, 19.5099999109904, 21.3122222688463, 17.67888895670573 in tunnel 1570293 10.1073/pnas.89.9.3751 1992 ProTherm 38 38 164 L46A Endolysin Enterobacteria phage T4 2.5 89.8 -8.6 yes 43.2 Potassium phosphate 0.020 M KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 20.983750104904175, 18.0349999666214 in tunnel in pocket 1553543 10.1126/science.1553543 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 151 38 164 L46A Endolysin Enterobacteria phage T4 89.0 -8.39 yes 43.26 H3PO4,KH2PO4, 3 mM,17 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 20.983750104904175, 18.0349999666214 in tunnel in pocket 1570293 10.1073/pnas.89.9.3751 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 158 38 164 L46A Endolysin Enterobacteria phage T4 88.0 -6.4 yes 55.8 KH2PO4 0.01 M KCl 0.15 M CD Thermal 6.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 20.983750104904175, 18.0349999666214 in tunnel in pocket 1570293 10.1073/pnas.89.9.3751 1992 ProTherm HotMuSiC_S1626.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 2925 38 164 L46A Endolysin Enterobacteria phage T4 114.0 -6.3 Unknown 58.9 Sodium acetate 0.01 M NaCl 0.1 M CD Thermal 5.45 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 20.983750104904175, 18.0349999666214 in tunnel in pocket 8114100 10.1006/jmbi.1994.1195 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7071 38 164 L46A Endolysin Enterobacteria phage T4 1.86 yes KH2PO4 0.01 M 62.2 KCl 0.15 M CD Thermal 6.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 20.983750104904175, 18.0349999666214 in tunnel in pocket 1570293 10.1073/pnas.89.9.3751 1992 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 7417 38 164 L46A Endolysin Enterobacteria phage T4 4.5 2.1 Unknown Sodium acetate 0.01 M 53.0 NaCl 0.1 M CD Thermal 5.45 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 20.983750104904175, 18.0349999666214 in tunnel in pocket 8114100 10.1006/jmbi.1994.1195 1994 ProTherm capriotti_S1615_map.csv 7499 38 164 L46A Endolysin Enterobacteria phage T4 2.5 2.7 yes Potassium phosphate 0.020 M 51.8 KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 20.983750104904175, 18.0349999666214 in tunnel in pocket 1553543 10.1126/science.1553543 1992 ProTherm capriotti_S1615_map.csv 7546 38 164 L46A Endolysin Enterobacteria phage T4 2.62 yes H3PO4,KH2PO4 3 mM,17 mM 51.65 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 20.983750104904175, 18.0349999666214 in tunnel in pocket 1570293 10.1073/pnas.89.9.3751 1992 ProTherm capriotti_S1615_map.csv 152 92 164 D47A Endolysin Enterobacteria phage T4 114.0 -0.81 yes 50.84 H3PO4,KH2PO4, 3 mM,17 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 21.792500019073486, 27.502500295639038 in pocket 1570293 10.1073/pnas.89.9.3751 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 159 92 164 D47A Endolysin Enterobacteria phage T4 113.0 -2.75 yes 59.45 KH2PO4 0.01 M KCl 0.15 M CD Thermal 6.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 21.792500019073486, 27.502500295639038 in pocket 1570293 10.1073/pnas.89.9.3751 1992 ProTherm HotMuSiC_S1626.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7072 92 164 D47A Endolysin Enterobacteria phage T4 0.95 yes KH2PO4 0.01 M 62.2 KCl 0.15 M CD Thermal 6.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 21.792500019073486, 27.502500295639038 in pocket 1570293 10.1073/pnas.89.9.3751 1992 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, potapov_with_uniprot_mapping.csv 7547 92 164 D47A Endolysin Enterobacteria phage T4 0.28 yes H3PO4,KH2PO4 3 mM,17 mM 51.65 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 21.792500019073486, 27.502500295639038 in pocket 1570293 10.1073/pnas.89.9.3751 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 153 93 164 K48A Endolysin Enterobacteria phage T4 109.0 -0.93 yes 50.72 H3PO4,KH2PO4, 3 mM,17 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.5099999109904, 17.67888895670573 in tunnel 1570293 10.1073/pnas.89.9.3751 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 160 93 164 K48A Endolysin Enterobacteria phage T4 110.0 -1.68 yes 60.52 KH2PO4 0.01 M KCl 0.15 M CD Thermal 6.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.5099999109904, 17.67888895670573 in tunnel 1570293 10.1073/pnas.89.9.3751 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4071 93 164 K48A Endolysin Enterobacteria phage T4 93.21 -12.5 yes 41.6 glycine-HCl 20 mM DSC Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.5099999109904, 17.67888895670573 in tunnel 8889173 10.1016/S0006-3495(96)79397-9 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4072 93 164 K48A Endolysin Enterobacteria phage T4 104.21 -12.2 yes 49.9 glycine-HCl 20 mM DSC Thermal 3.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.5099999109904, 17.67888895670573 in tunnel 8889173 10.1016/S0006-3495(96)79397-9 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4073 93 164 K48A Endolysin Enterobacteria phage T4 102.77 yes 54.6 glycine-HCl 20 mM DSC Thermal 4.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.5099999109904, 17.67888895670573 in tunnel 8889173 10.1016/S0006-3495(96)79397-9 1996 ProTherm 7073 93 164 K48A Endolysin Enterobacteria phage T4 0.56 yes KH2PO4 0.01 M 62.2 KCl 0.15 M CD Thermal 6.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.5099999109904, 17.67888895670573 in tunnel 1570293 10.1073/pnas.89.9.3751 1992 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, potapov_with_uniprot_mapping.csv 7548 93 164 K48A Endolysin Enterobacteria phage T4 0.32 yes H3PO4,KH2PO4 3 mM,17 mM 51.65 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.5099999109904, 17.67888895670573 in tunnel 1570293 10.1073/pnas.89.9.3751 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 417 231 164 A49S Endolysin Enterobacteria phage T4 110.0 -1.53 yes 50.02 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 18.158000183105468, 14.794000053405762 in tunnel 8218201 10.1021/bi00093a013 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7586 231 164 A49S Endolysin Enterobacteria phage T4 0.5 yes Potassium phosphate 20 mM 51.55 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 18.158000183105468, 14.794000053405762 in tunnel 8218201 10.1021/bi00093a013 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 2020 1126 164 I50A Endolysin Enterobacteria phage T4 116.0 -4.2 Yes(80%) 2.0 61.1 acetic acid, sodium acetate 1.4 mM, 8.6 mM Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 23.328749895095825, 20.94374990463257 10545167 10.1021/bi9915519 1999 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, M47andM8_S1810.csv 3127 1126 164 I50A Endolysin Enterobacteria phage T4 1.8 94.0 -5.8 Unknown 45.9 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 23.328749895095825, 20.94374990463257 9514271 10.1002/pro.5560070117 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6787 1126 164 I50A Endolysin Enterobacteria phage T4 1.6 Yes(80%) 2.0 acetic acid, sodium acetate 1.4 mM, 8.6 mM 65.3 Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 23.328749895095825, 20.94374990463257 10545167 10.1021/bi9915519 1999 ProTherm khan_protherm_data_mapped.csv 7561 1126 164 I50A Endolysin Enterobacteria phage T4 1.8 2.0 Unknown Potassium phosphate 20 mM 51.65 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 23.328749895095825, 20.94374990463257 9514271 10.1002/pro.5560070117 1998 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 10022 1126 164 I50A Endolysin Enterobacteria phage T4 2.9 12.0 2.6 Unknown Potassium phosphate 20 mM 25.0 NaCl 100 mM CD Urea 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 23.328749895095825, 20.94374990463257 17400925 10.1110/ps.062632807 2007 ProTherm SAAFEC_S1262.csv 2040 1140 164 I50M Endolysin Enterobacteria phage T4 120.0 -0.6 Yes(80%) 2.0 64.7 acetic acid, sodium acetate 1.4 mM, 8.6 mM Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 23.328749895095825, 20.94374990463257 10545167 10.1021/bi9915519 1999 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, HotMuSiC_S1626.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, STRUM_Q306.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S499.csv 6807 1140 164 I50M Endolysin Enterobacteria phage T4 0.4 Yes(80%) 2.0 acetic acid, sodium acetate 1.4 mM, 8.6 mM 65.3 Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 23.328749895095825, 20.94374990463257 10545167 10.1021/bi9915519 1999 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 12606 5831 164 G51D Endolysin Enterobacteria phage T4 5.0 2.63 Unknown imidazole,MOPS, 0.05 M,0.05 M, 22.0 Gel electrophoresis Urea 7.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 26.644999980926514, 27.269999504089355 1988046 10.1021/bi00216a038 1991 ProTherm SAAFEC_S1262.csv 15799 7405 164 R52A, N53A, C54A, N55A, G56A, V57A, I58A Endolysin Enterobacteria phage T4 1.8 40.0 -16.4 yes(>90%) 37.0 KPO4 20.0 mM KCl 25.0 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 1.0, 7.0, 4.0, 8.0, 4.0, 8.0 1L63, 2LZM 27.848181811246004, 52.417500019073486, 28.41428565979004, 53.32499980926514, 22.512499809265137, 28.925714220319474, 22.257499933242798, 35.80727282437411, 44.31750011444092, 30.27166684468587, 37.977500438690186, 25.40250015258789, 28.97571427481515, 20.97374987602234 in pocket 12487988 10.1016/s0301-4622(02)00193-x 2002 ProTherm 15797 7403 164 N53A, N55A, V57A Endolysin Enterobacteria phage T4 1.8 104.0 -4.0 yes(>90%) 49.4 KPO4 20.0 mM KCl 25.0 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0, 4.0, 4.0 1L63, 2LZM 52.417500019073486, 53.32499980926514, 28.925714220319474, 44.31750011444092, 37.977500438690186, 28.97571427481515 in pocket 12487988 10.1016/s0301-4622(02)00193-x 2002 ProTherm 16783 7403 164 N53A, N55A, V57A Endolysin Enterobacteria phage T4 1.8 1.5 yes(>90%) KPO4 20.0 mM 53.4 KCl 25.0 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0, 4.0, 4.0 1L63, 2LZM 52.417500019073486, 53.32499980926514, 28.925714220319474, 44.31750011444092, 37.977500438690186, 28.97571427481515 in pocket 12487988 10.1016/s0301-4622(02)00193-x 2002 ProTherm 15798 7404 164 N53A, C54A, N55A, G56A, V57A, I58A Endolysin Enterobacteria phage T4 1.8 43.0 -15.8 yes(>90%) 37.6 KPO4 20.0 mM KCl 25.0 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0, 7.0, 4.0, 8.0, 4.0, 8.0 1L63, 2LZM 52.417500019073486, 28.41428565979004, 53.32499980926514, 22.512499809265137, 28.925714220319474, 22.257499933242798, 44.31750011444092, 30.27166684468587, 37.977500438690186, 25.40250015258789, 28.97571427481515, 20.97374987602234 in pocket 12487988 10.1016/s0301-4622(02)00193-x 2002 ProTherm 15800 7406 164 N53A, N55A, V57A, E128A, V131A, N132A Endolysin Enterobacteria phage T4 1.8 105.0 -2.0 yes(>90%) 53.9 KPO4 20.0 mM KCl 25.0 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 1.0, 4.0, 4.0, 1.0, 2.0, 6.0 1L63, 2LZM 52.417500019073486, 53.32499980926514, 28.925714220319474, 46.15444416469998, 22.488571166992188, 18.553750157356262, 44.31750011444092, 37.977500438690186, 28.97571427481515, 30.945555051167805, 16.635714530944824, 16.804999947547913 in pocket 12487988 10.1016/s0301-4622(02)00193-x 2002 ProTherm 16784 7406 164 N53A, N55A, V57A, E128A, V131A, N132A Endolysin Enterobacteria phage T4 1.8 0.8 yes(>90%) KPO4 20.0 mM 53.4 KCl 25.0 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 1.0, 4.0, 4.0, 1.0, 2.0, 6.0 1L63, 2LZM 52.417500019073486, 53.32499980926514, 28.925714220319474, 46.15444416469998, 22.488571166992188, 18.553750157356262, 44.31750011444092, 37.977500438690186, 28.97571427481515, 30.945555051167805, 16.635714530944824, 16.804999947547913 in pocket 12487988 10.1016/s0301-4622(02)00193-x 2002 ProTherm 15801 7407 164 N53A, C54A, N55A, G56A, V57A, I58A, E62A Endolysin Enterobacteria phage T4 1.8 42.0 -16.4 yes(>90%) 37.0 KPO4 20.0 mM KCl 25.0 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0, 7.0, 4.0, 8.0, 4.0, 8.0, 7.0 1L63, 2LZM 52.417500019073486, 28.41428565979004, 53.32499980926514, 22.512499809265137, 28.925714220319474, 22.257499933242798, 19.083333333333332, 44.31750011444092, 30.27166684468587, 37.977500438690186, 25.40250015258789, 28.97571427481515, 20.97374987602234, 21.625555674235027 in pocket 12487988 10.1016/s0301-4622(02)00193-x 2002 ProTherm 814 501 164 C54V Endolysin Enterobacteria phage T4 -2.0 yes 63.0 Unknown KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 28.41428565979004, 30.27166684468587 in pocket 3277175 10.1073/pnas.85.2.401 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6642 501 164 C54V Endolysin Enterobacteria phage T4 0.7 yes Unknown 70.0 KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 28.41428565979004, 30.27166684468587 in pocket 3277175 10.1073/pnas.85.2.401 1988 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 815 502 164 C54T Endolysin Enterobacteria phage T4 1.0 yes 66.0 Unknown KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 28.41428565979004, 30.27166684468587 in pocket 3277175 10.1073/pnas.85.2.401 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3030 502 164 C54T Endolysin Enterobacteria phage T4 3.5 Unknown 69.0 Unknown CD Thermal 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 28.41428565979004, 30.27166684468587 in pocket 3689874 10.1002/bip.360261104 1987 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6643 502 164 C54T Endolysin Enterobacteria phage T4 -0.3 yes Unknown 70.0 KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 28.41428565979004, 30.27166684468587 in pocket 3277175 10.1073/pnas.85.2.401 1988 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 6764 502 164 C54T Endolysin Enterobacteria phage T4 -1.36 Unknown Unknown 65.5 CD Thermal 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 28.41428565979004, 30.27166684468587 in pocket 3689874 10.1002/bip.360261104 1987 ProTherm capriotti_S1615_map.csv 12607 5832 164 C54Y Endolysin Enterobacteria phage T4 3.8 5.02 Unknown imidazole,MOPS, 0.05 M,0.05 M, 22.0 Gel electrophoresis Urea 7.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 28.41428565979004, 30.27166684468587 in pocket 1988046 10.1021/bi00216a038 1991 ProTherm SAAFEC_S1262.csv 14536 6764 164 C54V, C97S Endolysin Enterobacteria phage T4 -6.0 yes 59.0 Unknown KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 5.0 1L63, 2LZM 28.41428565979004, 11.502000045776366, 30.27166684468587, 11.108333428700766 in pocket 3277175 10.1073/pnas.85.2.401 1988 ProTherm 14882 6764 164 C54V, C97S Endolysin Enterobacteria phage T4 2.1 yes Unknown 70.0 KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 5.0 1L63, 2LZM 28.41428565979004, 11.502000045776366, 30.27166684468587, 11.108333428700766 in pocket 3277175 10.1073/pnas.85.2.401 1988 ProTherm 14551 6770 164 C54T, C97A Endolysin Enterobacteria phage T4 77.0 yes 28.5 HCl 10 mM KCl 0.15 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 5.0 1L63, 2LZM 28.41428565979004, 11.502000045776366, 30.27166684468587, 11.108333428700766 in pocket 1854726 10.1021/bi00243a015 1991 ProTherm 14552 6770 164 C54T, C97A Endolysin Enterobacteria phage T4 132.0 yes 65.4 HCl 10 mM KCl 0.15 M CD Thermal 5.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 5.0 1L63, 2LZM 28.41428565979004, 11.502000045776366, 30.27166684468587, 11.108333428700766 in pocket 1854726 10.1021/bi00243a015 1991 ProTherm 14553 6770 164 C54T, C97A Endolysin Enterobacteria phage T4 131.0 yes 63.0 HCl 10 mM KCl 0.15 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 5.0 1L63, 2LZM 28.41428565979004, 11.502000045776366, 30.27166684468587, 11.108333428700766 in pocket 1854726 10.1021/bi00243a015 1991 ProTherm 14554 6770 164 C54T, C97A Endolysin Enterobacteria phage T4 yes 38.8 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 5.0 1L63, 2LZM 28.41428565979004, 11.502000045776366, 30.27166684468587, 11.108333428700766 in pocket 1737020 10.1021/bi00121a009 1992 ProTherm 14555 6770 164 C54T, C97A Endolysin Enterobacteria phage T4 yes 46.2 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 5.0 1L63, 2LZM 28.41428565979004, 11.502000045776366, 30.27166684468587, 11.108333428700766 in pocket 1737020 10.1021/bi00121a009 1992 ProTherm 14556 6770 164 C54T, C97A Endolysin Enterobacteria phage T4 yes 53.6 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 5.0 1L63, 2LZM 28.41428565979004, 11.502000045776366, 30.27166684468587, 11.108333428700766 in pocket 1737020 10.1021/bi00121a009 1992 ProTherm 14975 6770 164 C54T, C97A Endolysin Enterobacteria phage T4 3.2 1.27 yes Potassium phosphate 20 mM 53.6 KCl 25 mM DSC Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 5.0 1L63, 2LZM 28.41428565979004, 11.502000045776366, 30.27166684468587, 11.108333428700766 in pocket 1737020 10.1021/bi00121a009 1992 ProTherm 15075 6770 164 C54T, C97A Endolysin Enterobacteria phage T4 3.2 0.77 yes Potassium phosphate 20 mM 46.2 KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 5.0 1L63, 2LZM 28.41428565979004, 11.502000045776366, 30.27166684468587, 11.108333428700766 in pocket 1737020 10.1021/bi00121a009 1992 ProTherm 15118 6770 164 C54T, C97A Endolysin Enterobacteria phage T4 3.2 0.34 yes Potassium phosphate 20 mM 38.8 KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 5.0 1L63, 2LZM 28.41428565979004, 11.502000045776366, 30.27166684468587, 11.108333428700766 in pocket 1737020 10.1021/bi00121a009 1992 ProTherm 703 432 164 N55G Endolysin Enterobacteria phage T4 -1.7 yes 40.2 KH2PO4 100 mM KCl 100 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 53.32499980926514, 37.977500438690186 in pocket 2511328 10.1016/0022-2836(89)90299-4 1989 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 705 432 164 N55G Endolysin Enterobacteria phage T4 -1.6 yes 63.1 KH2PO4 100 mM KCl 100 mM CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 53.32499980926514, 37.977500438690186 in pocket 2511328 10.1016/0022-2836(89)90299-4 1989 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6983 432 164 N55G Endolysin Enterobacteria phage T4 0.6 yes KH2PO4 100 mM 64.7 KCl 100 mM CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 53.32499980926514, 37.977500438690186 in pocket 2511328 10.1016/0022-2836(89)90299-4 1989 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, potapov_with_uniprot_mapping.csv 8031 432 164 N55G Endolysin Enterobacteria phage T4 0.5 yes KH2PO4 100 mM 41.9 KCl 100 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 53.32499980926514, 37.977500438690186 in pocket 2511328 10.1016/0022-2836(89)90299-4 1989 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 3623 1879 164 N55C Endolysin Enterobacteria phage T4 -3.6 yes 32.8 Potassium phosphate 20 mM KCl 25 mM CD Thermal 2.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 53.32499980926514, 37.977500438690186 in pocket 1510962 10.1021/bi00149a004 1992 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 384 203 164 I58T Endolysin Enterobacteria phage T4 84.0 -10.1 Unknown 55.2 sodium acetate 0.010 M NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 22.257499933242798, 20.97374987602234 11316887 10.1110/ps.02101 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7117 203 164 I58T Endolysin Enterobacteria phage T4 3.4 Unknown sodium acetate 0.010 M 59.0 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 22.257499933242798, 20.97374987602234 11316887 10.1110/ps.02101 2001 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3128 1676 164 I58A Endolysin Enterobacteria phage T4 1.8 80.0 -10.4 Unknown 41.3 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 22.257499933242798, 20.97374987602234 9514271 10.1002/pro.5560070117 1998 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, EASE-MM_S543.csv, PoPMuSiC-2.0_S2648.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7562 1676 164 I58A Endolysin Enterobacteria phage T4 1.8 3.2 Unknown Potassium phosphate 20 mM 51.65 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 22.257499933242798, 20.97374987602234 9514271 10.1002/pro.5560070117 1998 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 12608 5833 164 I58Y Endolysin Enterobacteria phage T4 4.8 3.11 Unknown imidazole,MOPS, 0.05 M,0.05 M, 22.0 Gel electrophoresis Urea 7.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 22.257499933242798, 20.97374987602234 1988046 10.1021/bi00216a038 1991 ProTherm SAAFEC_S1262.csv 978 578 164 T59N Endolysin Enterobacteria phage T4 -2.1 yes 38.9 KCl-HCl KCl 15 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 25.815714154924667, 23.795714242117747 1567817 10.1021/bi00129a006 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 984 578 164 T59N Endolysin Enterobacteria phage T4 -2.8 yes 60.2 Potassium phosphate 10 mM KCl 15 mM CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 25.815714154924667, 23.795714242117747 1567817 10.1021/bi00129a006 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7041 578 164 T59N Endolysin Enterobacteria phage T4 1.1 yes Potassium phosphate 10 mM 63.0 KCl 15 mM CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 25.815714154924667, 23.795714242117747 1567817 10.1021/bi00129a006 1992 ProTherm capriotti_S1615_map.csv 8057 578 164 T59N Endolysin Enterobacteria phage T4 0.6 yes HCl 41.0 KCl 15 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 25.815714154924667, 23.795714242117747 1567817 10.1021/bi00129a006 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 979 579 164 T59S Endolysin Enterobacteria phage T4 -2.6 yes 38.4 KCl-HCl KCl 15 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 25.815714154924667, 23.795714242117747 1567817 10.1021/bi00129a006 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 985 579 164 T59S Endolysin Enterobacteria phage T4 -0.4 yes 62.6 Potassium phosphate 10 mM KCl 15 mM CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 25.815714154924667, 23.795714242117747 1567817 10.1021/bi00129a006 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7042 579 164 T59S Endolysin Enterobacteria phage T4 0.2 yes Potassium phosphate 10 mM 63.0 KCl 15 mM CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 25.815714154924667, 23.795714242117747 1567817 10.1021/bi00129a006 1992 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8058 579 164 T59S Endolysin Enterobacteria phage T4 0.7 yes HCl 41.0 KCl 15 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 25.815714154924667, 23.795714242117747 1567817 10.1021/bi00129a006 1992 ProTherm capriotti_S1615_map.csv 980 580 164 T59D Endolysin Enterobacteria phage T4 -3.1 yes 37.9 KCl-HCl KCl 15 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 25.815714154924667, 23.795714242117747 1567817 10.1021/bi00129a006 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 986 580 164 T59D Endolysin Enterobacteria phage T4 -3.1 yes 59.9 Potassium phosphate 10 mM KCl 15 mM CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 25.815714154924667, 23.795714242117747 1567817 10.1021/bi00129a006 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7043 580 164 T59D Endolysin Enterobacteria phage T4 1.2 yes Potassium phosphate 10 mM 63.0 KCl 15 mM CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 25.815714154924667, 23.795714242117747 1567817 10.1021/bi00129a006 1992 ProTherm capriotti_S1615_map.csv 8059 580 164 T59D Endolysin Enterobacteria phage T4 0.9 yes HCl 41.0 KCl 15 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 25.815714154924667, 23.795714242117747 1567817 10.1021/bi00129a006 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 981 581 164 T59G Endolysin Enterobacteria phage T4 -7.7 yes 33.7 KCl-HCl KCl 15 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 25.815714154924667, 23.795714242117747 1567817 10.1021/bi00129a006 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 987 581 164 T59G Endolysin Enterobacteria phage T4 -4.1 yes 58.9 Potassium phosphate 10 mM KCl 15 mM CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 25.815714154924667, 23.795714242117747 1567817 10.1021/bi00129a006 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7044 581 164 T59G Endolysin Enterobacteria phage T4 1.6 yes Potassium phosphate 10 mM 63.0 KCl 15 mM CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 25.815714154924667, 23.795714242117747 1567817 10.1021/bi00129a006 1992 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8060 581 164 T59G Endolysin Enterobacteria phage T4 2.2 yes HCl 41.0 KCl 15 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 25.815714154924667, 23.795714242117747 1567817 10.1021/bi00129a006 1992 ProTherm capriotti_S1615_map.csv 982 582 164 T59V Endolysin Enterobacteria phage T4 -10.0 yes 31.0 KCl-HCl KCl 15 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 25.815714154924667, 23.795714242117747 1567817 10.1021/bi00129a006 1992 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 988 582 164 T59V Endolysin Enterobacteria phage T4 -4.0 yes 59.0 Potassium phosphate 10 mM KCl 15 mM CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 25.815714154924667, 23.795714242117747 1567817 10.1021/bi00129a006 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7045 582 164 T59V Endolysin Enterobacteria phage T4 1.5 yes Potassium phosphate 10 mM 63.0 KCl 15 mM CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 25.815714154924667, 23.795714242117747 1567817 10.1021/bi00129a006 1992 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8061 582 164 T59V Endolysin Enterobacteria phage T4 2.8 yes HCl 41.0 KCl 15 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 25.815714154924667, 23.795714242117747 1567817 10.1021/bi00129a006 1992 ProTherm capriotti_S1615_map.csv 983 583 164 T59A Endolysin Enterobacteria phage T4 -10.1 yes 30.9 KCl-HCl KCl 15 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 25.815714154924667, 23.795714242117747 1567817 10.1021/bi00129a006 1992 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 989 583 164 T59A Endolysin Enterobacteria phage T4 -4.0 yes 59.0 Potassium phosphate 10 mM KCl 15 mM CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 25.815714154924667, 23.795714242117747 1567817 10.1021/bi00129a006 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7046 583 164 T59A Endolysin Enterobacteria phage T4 1.5 yes Potassium phosphate 10 mM 63.0 KCl 15 mM CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 25.815714154924667, 23.795714242117747 1567817 10.1021/bi00129a006 1992 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8062 583 164 T59A Endolysin Enterobacteria phage T4 2.8 yes HCl 41.0 KCl 15 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 25.815714154924667, 23.795714242117747 1567817 10.1021/bi00129a006 1992 ProTherm capriotti_S1615_map.csv 785 479 164 K60P Endolysin Enterobacteria phage T4 0.3 yes 42.2 H3PO4,HCl, 10 mM,10 mM, KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 42.435555352105034, 33.772222730848526 1457724 10.1002/bip.360321103 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 790 479 164 K60P Endolysin Enterobacteria phage T4 -0.1 yes 64.6 Potassium phosphate 10 mM KCl 0.15 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 42.435555352105034, 33.772222730848526 1457724 10.1002/bip.360321103 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6999 479 164 K60P Endolysin Enterobacteria phage T4 0.0 yes Potassium phosphate 10 mM 64.7 KCl 0.15 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 42.435555352105034, 33.772222730848526 1457724 10.1002/bip.360321103 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8046 479 164 K60P Endolysin Enterobacteria phage T4 -0.1 yes H3PO4,HCl 10 mM,10 mM 41.9 KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 42.435555352105034, 33.772222730848526 1457724 10.1002/bip.360321103 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3413 1775 164 K60H Endolysin Enterobacteria phage T4 75.0 -3.4 yes 35.1 HCl 10 mM KCl 0.15 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 42.435555352105034, 33.772222730848526 1854726 10.1021/bi00243a015 1991 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3414 1775 164 K60H Endolysin Enterobacteria phage T4 115.0 -0.4 yes 62.6 Potassium phosphate 10 mM KCl 0.15 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 42.435555352105034, 33.772222730848526 1854726 10.1021/bi00243a015 1991 ProTherm Broom_S605.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7038 1775 164 K60H Endolysin Enterobacteria phage T4 0.1 yes Potassium phosphate 10 mM 63.0 KCl 0.15 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 42.435555352105034, 33.772222730848526 1854726 10.1021/bi00243a015 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 8425 1775 164 K60H Endolysin Enterobacteria phage T4 0.8 yes HCl 10 mM 28.5 KCl 0.15 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 42.435555352105034, 33.772222730848526 1854726 10.1021/bi00243a015 1991 ProTherm capriotti_S1615_map.csv 2021 1127 164 L66A Endolysin Enterobacteria phage T4 84.0 -10.1 Yes(80%) 2.0 55.2 acetic acid, sodium acetate 1.4 mM, 8.6 mM Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 16.107500195503235, 14.618749916553497 in tunnel 10545167 10.1021/bi9915519 1999 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, M47andM8_S1810.csv 3143 1127 164 L66A Endolysin Enterobacteria phage T4 1.8 69.0 -13.4 Unknown 38.3 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 16.107500195503235, 14.618749916553497 in tunnel 9514271 10.1002/pro.5560070117 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6788 1127 164 L66A Endolysin Enterobacteria phage T4 3.3 Yes(80%) 2.0 acetic acid, sodium acetate 1.4 mM, 8.6 mM 65.3 Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 16.107500195503235, 14.618749916553497 in tunnel 10545167 10.1021/bi9915519 1999 ProTherm khan_protherm_data_mapped.csv 7577 1127 164 L66A Endolysin Enterobacteria phage T4 1.8 3.9 Unknown Potassium phosphate 20 mM 51.65 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 16.107500195503235, 14.618749916553497 in tunnel 9514271 10.1002/pro.5560070117 1998 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 2041 1141 164 L66M Endolysin Enterobacteria phage T4 122.0 -2.5 Yes(80%) 2.0 62.6 acetic acid, sodium acetate 1.4 mM, 8.6 mM Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 16.107500195503235, 14.618749916553497 in tunnel 10545167 10.1021/bi9915519 1999 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, HotMuSiC_S1626.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, STRUM_Q306.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S499.csv 6808 1141 164 L66M Endolysin Enterobacteria phage T4 1.0 Yes(80%) 2.0 acetic acid, sodium acetate 1.4 mM, 8.6 mM 65.3 Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 16.107500195503235, 14.618749916553497 in tunnel 10545167 10.1021/bi9915519 1999 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 4056 2067 164 L66P Endolysin Enterobacteria phage T4 -38.2 no 26.8 Potassium phosphate 10 mM KCl 0.15 M CD Thermal 7.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 16.107500195503235, 14.618749916553497 in tunnel 8845764 10.1002/pro.5560050419 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 11100 2067 164 L66P Endolysin Enterobacteria phage T4 2.53 12.23 4.32 1.71 no Potassium phosphate 10 mM 25.0 KCl 0.15 M CD Urea 7.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 16.107500195503235, 14.618749916553497 in tunnel 8845764 10.1002/pro.5560050419 1996 ProTherm 3139 1679 164 F67A Endolysin Enterobacteria phage T4 1.8 101.0 -5.7 Unknown 46.0 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.855454444885254, 14.848182071339 in pocket 9514271 10.1002/pro.5560070117 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7573 1679 164 F67A Endolysin Enterobacteria phage T4 1.8 1.9 Unknown Potassium phosphate 20 mM 51.65 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.855454444885254, 14.848182071339 in pocket 9514271 10.1002/pro.5560070117 1998 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3546 1841 164 N68A Endolysin Enterobacteria phage T4 -0.2 Unknown 48.0 Potassium phosphate 20 mM KCl 25 mM CD Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 19.950000166893005, 21.21250021457672 in pocket 7918421 10.1021/bi00206a003 1994 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7786 1841 164 N68A Endolysin Enterobacteria phage T4 0.05 Unknown Potassium phosphate 20 mM 47.8 KCl 25 mM CD Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 19.950000166893005, 21.21250021457672 in pocket 7918421 10.1021/bi00206a003 1994 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 450 252 164 Q69P Endolysin Enterobacteria phage T4 -12.9 yes 25.6 HCl 10 mM KCl 150 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 17.163333468967014, 13.479999860127768 in tunnel 1733941 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 452 252 164 Q69P Endolysin Enterobacteria phage T4 -7.6 yes 55.6 Potassium phosphate 10 mM KCl 150 mM CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 17.163333468967014, 13.479999860127768 in tunnel 1733941 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7037 252 164 Q69P Endolysin Enterobacteria phage T4 2.9 yes Potassium phosphate 10 mM 63.2 KCl 150 mM CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 17.163333468967014, 13.479999860127768 in tunnel 1733941 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 8222 252 164 Q69P Endolysin Enterobacteria phage T4 3.3 yes HCl 10 mM 38.5 KCl 150 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 17.163333468967014, 13.479999860127768 in tunnel 1733941 1992 ProTherm capriotti_S1615_map.csv 3131 1677 164 V71A Endolysin Enterobacteria phage T4 1.8 108.0 -4.7 Unknown 47.0 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 12.867142813546318, 9.491428443363734 in tunnel 9514271 10.1002/pro.5560070117 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7565 1677 164 V71A Endolysin Enterobacteria phage T4 1.8 1.5 Unknown Potassium phosphate 20 mM 51.65 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 12.867142813546318, 9.491428443363734 in tunnel 9514271 10.1002/pro.5560070117 1998 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 451 253 164 D72P Endolysin Enterobacteria phage T4 -10.2 yes 28.3 HCl 10 mM KCl 150 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 23.292500019073486, 20.343750476837158 in tunnel 1733941 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 453 253 164 D72P Endolysin Enterobacteria phage T4 -6.9 yes 56.3 Potassium phosphate 10 mM KCl 150 mM CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 23.292500019073486, 20.343750476837158 in tunnel 1733941 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7035 253 164 D72P Endolysin Enterobacteria phage T4 2.7 yes Potassium phosphate 10 mM 63.4 KCl 150 mM CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 23.292500019073486, 20.343750476837158 in tunnel 1733941 1992 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 8223 253 164 D72P Endolysin Enterobacteria phage T4 2.6 yes HCl 10 mM 38.5 KCl 150 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 23.292500019073486, 20.343750476837158 in tunnel 1733941 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 418 232 164 A73S Endolysin Enterobacteria phage T4 111.0 -1.27 yes 50.28 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 19.23400001525879, 16.08599967956543 in tunnel in pocket 8218201 10.1021/bi00093a013 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7587 232 164 A73S Endolysin Enterobacteria phage T4 0.4 yes Potassium phosphate 20 mM 51.55 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 19.23400001525879, 16.08599967956543 in tunnel in pocket 8218201 10.1021/bi00093a013 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 454 254 164 A74P Endolysin Enterobacteria phage T4 -12.4 yes 50.8 Potassium phosphate 10 mM KCl 150 mM CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 18.63400001525879, 17.185999870300293 in tunnel in pocket 1733941 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 455 254 164 A74P Endolysin Enterobacteria phage T4 -18.2 yes 39.3 Potassium phosphate 10 mM KCl 150 mM CD Thermal 3.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 18.63400001525879, 17.185999870300293 in tunnel in pocket 1733941 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 456 254 164 A74P Endolysin Enterobacteria phage T4 -15.3 yes 46.9 Potassium phosphate 10 mM KCl 150 mM CD Thermal 4.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 18.63400001525879, 17.185999870300293 in tunnel in pocket 1733941 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 457 254 164 A74P Endolysin Enterobacteria phage T4 -12.4 yes 53.3 Potassium phosphate 10 mM KCl 150 mM CD Thermal 5.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 18.63400001525879, 17.185999870300293 in tunnel in pocket 1733941 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6757 254 164 A74P Endolysin Enterobacteria phage T4 4.5 yes Potassium phosphate 10 mM 65.7 KCl 150 mM CD Thermal 5.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 18.63400001525879, 17.185999870300293 in tunnel in pocket 1733941 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 7059 254 164 A74P Endolysin Enterobacteria phage T4 4.6 yes Potassium phosphate 10 mM 62.9 KCl 150 mM CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 18.63400001525879, 17.185999870300293 in tunnel in pocket 1733941 1992 ProTherm capriotti_S1615_map.csv 7074 254 164 A74P Endolysin Enterobacteria phage T4 5.0 yes Potassium phosphate 10 mM 62.2 KCl 150 mM CD Thermal 4.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 18.63400001525879, 17.185999870300293 in tunnel in pocket 1733941 1992 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 7161 254 164 A74P Endolysin Enterobacteria phage T4 5.7 yes Potassium phosphate 10 mM 57.5 KCl 150 mM CD Thermal 3.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 18.63400001525879, 17.185999870300293 in tunnel in pocket 1733941 1992 ProTherm capriotti_S1615_map.csv 424 238 164 V75T Endolysin Enterobacteria phage T4 113.0 -3.7 yes 47.85 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 24.69714300973075, 18.392857551574707 8218201 10.1021/bi00093a013 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7593 238 164 V75T Endolysin Enterobacteria phage T4 1.3 yes Potassium phosphate 20 mM 51.55 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 24.69714300973075, 18.392857551574707 8218201 10.1021/bi00093a013 1993 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 574 327 164 G77A Endolysin Enterobacteria phage T4 2.0 85.0 -1.4 yes 40.5 KH2PO4 100 mM KCl 100 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 23.5, 20.15250015258789 in pocket 3477797 10.1073/pnas.84.19.6663 1987 ProTherm potapov_with_uniprot_mapping.csv, M47andM8_S2760.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 576 327 164 G77A Endolysin Enterobacteria phage T4 2.0 125.0 0.94 yes 65.6 KH2PO4 100 mM KCl 100 mM CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 23.5, 20.15250015258789 in pocket 3477797 10.1073/pnas.84.19.6663 1987 ProTherm potapov_with_uniprot_mapping.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 786 327 164 G77A Endolysin Enterobacteria phage T4 85.0 -1.4 yes 40.5 H3PO4,HCl, 10 mM,10 mM, KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 23.5, 20.15250015258789 in pocket 1457724 10.1002/bip.360321103 1992 ProTherm potapov_with_uniprot_mapping.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 791 327 164 G77A Endolysin Enterobacteria phage T4 125.0 0.9 yes 65.6 Potassium phosphate 10 mM KCl 0.15 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 23.5, 20.15250015258789 in pocket 1457724 10.1002/bip.360321103 1992 ProTherm potapov_with_uniprot_mapping.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6981 327 164 G77A Endolysin Enterobacteria phage T4 2.0 -0.4 yes KH2PO4 100 mM 64.7 KCl 100 mM CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 23.5, 20.15250015258789 in pocket 3477797 10.1073/pnas.84.19.6663 1987 ProTherm potapov_with_uniprot_mapping.csv, capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 7000 327 164 G77A Endolysin Enterobacteria phage T4 -0.4 yes Potassium phosphate 10 mM 64.7 KCl 0.15 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 23.5, 20.15250015258789 in pocket 1457724 10.1002/bip.360321103 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8029 327 164 G77A Endolysin Enterobacteria phage T4 2.0 0.4 yes KH2PO4 100 mM 41.9 KCl 100 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 23.5, 20.15250015258789 in pocket 3477797 10.1073/pnas.84.19.6663 1987 ProTherm potapov_with_uniprot_mapping.csv, capriotti_S1615_map.csv 8047 327 164 G77A Endolysin Enterobacteria phage T4 0.4 yes H3PO4,HCl 10 mM,10 mM 41.9 KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 23.5, 20.15250015258789 in pocket 1457724 10.1002/bip.360321103 1992 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 12609 327 164 G77A Endolysin Enterobacteria phage T4 5.65 1.2 Unknown imidazole,MOPS, 0.05 M,0.05 M, 22.0 Gel electrophoresis Urea 7.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 23.5, 20.15250015258789 in pocket 1988046 10.1021/bi00216a038 1991 ProTherm potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 297 160 164 I78M Endolysin Enterobacteria phage T4 2.5 117.0 -3.7 Unknown 61.6 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 0.1 M CD Thermal 5.42 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 21.18875002861023, 19.55375027656555 in pocket 8901549 10.1073/pnas.93.22.12155 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6768 160 164 I78M Endolysin Enterobacteria phage T4 2.5 1.5 Unknown Acetic acid,Sodium acetate 1.4 mM,8.6 mM 65.3 NaCl 0.1 M CD Thermal 5.42 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 21.18875002861023, 19.55375027656555 in pocket 8901549 10.1073/pnas.93.22.12155 1996 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1420 804 164 I78V Endolysin Enterobacteria phage T4 127.0 -2.1 Unknown 63.4 sodium chloride, acetic acid, sodium acetate 0.10 M, 1.4 mM, 8.6 mM CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 21.18875002861023, 19.55375027656555 in pocket 12963380 10.1016/s0022-2836(03)00856-8 2003 ProTherm 7076 804 164 I78V Endolysin Enterobacteria phage T4 2.5 0.8 Unknown sodium chloride, acetic acid, sodium acetate 0.10 M, 1.4 mM, 8.6 mM 61.0 CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 21.18875002861023, 19.55375027656555 in pocket 12963380 10.1016/s0022-2836(03)00856-8 2003 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 2022 1128 164 I78A Endolysin Enterobacteria phage T4 127.0 -3.5 Yes(80%) 2.0 61.8 acetic acid, sodium acetate 1.4 mM, 8.6 mM Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 21.18875002861023, 19.55375027656555 in pocket 10545167 10.1021/bi9915519 1999 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, M47andM8_S1810.csv 3129 1128 164 I78A Endolysin Enterobacteria phage T4 1.8 105.0 -4.7 Unknown 47.0 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 21.18875002861023, 19.55375027656555 in pocket 9514271 10.1002/pro.5560070117 1998 ProTherm AUTOMUTE_S1749.csv, EASE-MM_S543.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S1791.csv 6789 1128 164 I78A Endolysin Enterobacteria phage T4 1.2 Yes(80%) 2.0 acetic acid, sodium acetate 1.4 mM, 8.6 mM 65.3 Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 21.18875002861023, 19.55375027656555 in pocket 10545167 10.1021/bi9915519 1999 ProTherm khan_protherm_data_mapped.csv 7563 1128 164 I78A Endolysin Enterobacteria phage T4 1.8 1.6 Unknown Potassium phosphate 20 mM 51.65 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 21.18875002861023, 19.55375027656555 in pocket 9514271 10.1002/pro.5560070117 1998 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3625 1880 164 L79C Endolysin Enterobacteria phage T4 -5.1 yes 31.3 Potassium phosphate 20 mM KCl 25 mM CD Thermal 2.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 25.228749990463257, 25.046250343322754 1510962 10.1021/bi00149a004 1992 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Broom_S605.csv, PON-TStab_dataset.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S1791.csv 194 100 164 R80K Endolysin Enterobacteria phage T4 3.5 136.0 -0.43 Unknown 64.72 Sodium acetate 10 mM NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 57.02181746742942, 43.70181881297719 in tunnel in pocket 7507755 10.1002/pro.5560021221 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 206 100 164 R80K Endolysin Enterobacteria phage T4 3.5 -0.34 Unknown 61.85 Potassium phosphate 0.01 M KCl 0.15 M CD Thermal 6.78 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 57.02181746742942, 43.70181881297719 in tunnel in pocket 7507755 10.1002/pro.5560021221 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6823 100 164 R80K Endolysin Enterobacteria phage T4 3.5 0.17 Unknown Sodium acetate 10 mM 65.15 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 57.02181746742942, 43.70181881297719 in tunnel in pocket 7507755 10.1002/pro.5560021221 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14460 6710 164 R80K, R119H Endolysin Enterobacteria phage T4 3.5 133.0 -1.2 Unknown 63.95 Sodium acetate 10 mM NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0, 4.0 1L63, 2LZM 57.02181746742942, 54.452727404507726, 43.70181881297719, 37.932726946744054 in tunnel in pocket 7507755 10.1002/pro.5560021221 1993 ProTherm 14461 6710 164 R80K, R119H Endolysin Enterobacteria phage T4 3.5 -1.25 Unknown 60.94 Potassium phosphate 0.01 M KCl 0.15 M CD Thermal 6.78 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0, 4.0 1L63, 2LZM 57.02181746742942, 54.452727404507726, 43.70181881297719, 37.932726946744054 in tunnel in pocket 7507755 10.1002/pro.5560021221 1993 ProTherm 14915 6710 164 R80K, R119H Endolysin Enterobacteria phage T4 3.5 0.47 Unknown Sodium acetate 10 mM 65.15 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0, 4.0 1L63, 2LZM 57.02181746742942, 54.452727404507726, 43.70181881297719, 37.932726946744054 in tunnel in pocket 7507755 10.1002/pro.5560021221 1993 ProTherm 419 233 164 A82S Endolysin Enterobacteria phage T4 112.0 -0.99 yes 50.56 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 26.978000259399415, 23.790000343322752 8218201 10.1021/bi00093a013 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7588 233 164 A82S Endolysin Enterobacteria phage T4 0.3 yes Potassium phosphate 20 mM 51.55 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 26.978000259399415, 23.790000343322752 8218201 10.1021/bi00093a013 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 575 328 164 A82P Endolysin Enterobacteria phage T4 2.0 90.0 0.8 yes 42.7 KH2PO4 100 mM KCl 100 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 26.978000259399415, 23.790000343322752 3477797 10.1073/pnas.84.19.6663 1987 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 577 328 164 A82P Endolysin Enterobacteria phage T4 2.0 126.0 2.1 yes 66.8 KH2PO4 100 mM KCl 100 mM CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 26.978000259399415, 23.790000343322752 3477797 10.1073/pnas.84.19.6663 1987 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 787 328 164 A82P Endolysin Enterobacteria phage T4 90.0 0.8 yes 42.7 H3PO4,HCl, 10 mM,10 mM, KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 26.978000259399415, 23.790000343322752 1457724 10.1002/bip.360321103 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 792 328 164 A82P Endolysin Enterobacteria phage T4 126.0 2.1 yes 66.8 Potassium phosphate 10 mM KCl 0.15 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 26.978000259399415, 23.790000343322752 1457724 10.1002/bip.360321103 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 890 328 164 A82P Endolysin Enterobacteria phage T4 yes 38.8 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 26.978000259399415, 23.790000343322752 1737020 10.1021/bi00121a009 1992 ProTherm 893 328 164 A82P Endolysin Enterobacteria phage T4 yes 46.2 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 26.978000259399415, 23.790000343322752 1737020 10.1021/bi00121a009 1992 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 896 328 164 A82P Endolysin Enterobacteria phage T4 yes 53.6 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 26.978000259399415, 23.790000343322752 1737020 10.1021/bi00121a009 1992 ProTherm 900 328 164 A82P Endolysin Enterobacteria phage T4 1.8 125.0 1.08 Unknown 54.5 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 26.978000259399415, 23.790000343322752 8771182 10.1093/protein/8.10.1017 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 907 328 164 A82P Endolysin Enterobacteria phage T4 2.5 142.0 1.34 Unknown 67.85 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 26.978000259399415, 23.790000343322752 8771182 10.1093/protein/8.10.1017 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 2995 328 164 A82P Endolysin Enterobacteria phage T4 0.8 yes 42.7 phosphate 50 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 26.978000259399415, 23.790000343322752 7074100 10.1021/bi00535a054 1982 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4658 328 164 A82P Endolysin Enterobacteria phage T4 0.8 yes 2.0 42.7 Phosphate buffer 50 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 26.978000259399415, 23.790000343322752 1737005 10.1021/bi00120a025 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6722 328 164 A82P Endolysin Enterobacteria phage T4 2.5 -0.57 Unknown Acetic acid, Sodium acetate 1.4 mM, 8.6 mM 66.51 NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 26.978000259399415, 23.790000343322752 8771182 10.1093/protein/8.10.1017 1995 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S983.csv 6982 328 164 A82P Endolysin Enterobacteria phage T4 2.0 -0.8 yes KH2PO4 100 mM 64.7 KCl 100 mM CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 26.978000259399415, 23.790000343322752 3477797 10.1073/pnas.84.19.6663 1987 ProTherm capriotti_S1615_map.csv 7001 328 164 A82P Endolysin Enterobacteria phage T4 -0.8 yes Potassium phosphate 10 mM 64.7 KCl 0.15 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 26.978000259399415, 23.790000343322752 1457724 10.1002/bip.360321103 1992 ProTherm capriotti_S1615_map.csv 7328 328 164 A82P Endolysin Enterobacteria phage T4 2.39 -1.27 yes Potassium phosphate 20 mM 53.6 KCl 25 mM DSC Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 26.978000259399415, 23.790000343322752 1737020 10.1021/bi00121a009 1992 ProTherm capriotti_S1615_map.csv 7337 328 164 A82P Endolysin Enterobacteria phage T4 1.8 -0.45 Unknown KH2PO4, H3PO4 17 mM, 3 mM 53.42 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 26.978000259399415, 23.790000343322752 8771182 10.1093/protein/8.10.1017 1995 ProTherm capriotti_S1615_map.csv 7846 328 164 A82P Endolysin Enterobacteria phage T4 2.39 -0.51 yes Potassium phosphate 20 mM 46.2 KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 26.978000259399415, 23.790000343322752 1737020 10.1021/bi00121a009 1992 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 8030 328 164 A82P Endolysin Enterobacteria phage T4 2.0 -0.3 yes KH2PO4 100 mM 41.9 KCl 100 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 26.978000259399415, 23.790000343322752 3477797 10.1073/pnas.84.19.6663 1987 ProTherm capriotti_S1615_map.csv 8048 328 164 A82P Endolysin Enterobacteria phage T4 -0.3 yes H3PO4,HCl 10 mM,10 mM 41.9 KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 26.978000259399415, 23.790000343322752 1457724 10.1002/bip.360321103 1992 ProTherm capriotti_S1615_map.csv 8210 328 164 A82P Endolysin Enterobacteria phage T4 2.39 0.07 yes Potassium phosphate 20 mM 38.8 KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 26.978000259399415, 23.790000343322752 1737020 10.1021/bi00121a009 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 12610 328 164 A82P Endolysin Enterobacteria phage T4 5.9 0.72 Unknown imidazole,MOPS, 0.05 M,0.05 M, 22.0 Gel electrophoresis Urea 7.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 26.978000259399415, 23.790000343322752 1988046 10.1021/bi00216a038 1991 ProTherm SAAFEC_S1262.csv 13903 328 164 A82P Endolysin Enterobacteria phage T4 2.58 18.6 yes 2.0 Phosphate buffer 50 mM 12.0 CD GdnHCl 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 26.978000259399415, 23.790000343322752 1737005 10.1021/bi00120a025 1992 ProTherm 3418 1777 164 K83H Endolysin Enterobacteria phage T4 80.0 -2.2 yes 36.3 HCl 10 mM KCl 0.15 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 50.93111080593533, 32.82888910505507 1854726 10.1021/bi00243a015 1991 ProTherm AUTOMUTE_S1962.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, Broom_S605.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3419 1777 164 K83H Endolysin Enterobacteria phage T4 122.0 -1.0 yes 62.0 Potassium phosphate 10 mM KCl 0.15 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 50.93111080593533, 32.82888910505507 1854726 10.1021/bi00243a015 1991 ProTherm AUTOMUTE_S1962.csv, Broom_S605.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, PoPMuSiC-2.0_S2648.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7040 1777 164 K83H Endolysin Enterobacteria phage T4 0.4 yes Potassium phosphate 10 mM 63.0 KCl 0.15 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 50.93111080593533, 32.82888910505507 1854726 10.1021/bi00243a015 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8427 1777 164 K83H Endolysin Enterobacteria phage T4 0.5 yes HCl 10 mM 28.5 KCl 0.15 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 50.93111080593533, 32.82888910505507 1854726 10.1021/bi00243a015 1991 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 14545 6768 164 K83H, A112D Endolysin Enterobacteria phage T4 73.0 -4.8 yes 33.7 HCl 10 mM KCl 0.15 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0, 6.0 1L63, 2LZM 50.93111080593533, 33.031999588012695, 32.82888910505507, 29.41199951171875 1854726 10.1021/bi00243a015 1991 ProTherm 14546 6768 164 K83H, A112D Endolysin Enterobacteria phage T4 122.0 -3.4 yes 62.0 HCl 10 mM KCl 0.15 M CD Thermal 5.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0, 6.0 1L63, 2LZM 50.93111080593533, 33.031999588012695, 32.82888910505507, 29.41199951171875 1854726 10.1021/bi00243a015 1991 ProTherm 14547 6768 164 K83H, A112D Endolysin Enterobacteria phage T4 119.0 -3.9 yes 59.1 HCl 10 mM KCl 0.15 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0, 6.0 1L63, 2LZM 50.93111080593533, 33.031999588012695, 32.82888910505507, 29.41199951171875 1854726 10.1021/bi00243a015 1991 ProTherm 14933 6768 164 K83H, A112D Endolysin Enterobacteria phage T4 1.2 yes HCl 10 mM 64.6 KCl 0.15 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0, 6.0 1L63, 2LZM 50.93111080593533, 33.031999588012695, 32.82888910505507, 29.41199951171875 1854726 10.1021/bi00243a015 1991 ProTherm 14934 6768 164 K83H, A112D Endolysin Enterobacteria phage T4 1.3 yes HCl 10 mM 64.6 KCl 0.15 M CD Thermal 5.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0, 6.0 1L63, 2LZM 50.93111080593533, 33.031999588012695, 32.82888910505507, 29.41199951171875 1854726 10.1021/bi00243a015 1991 ProTherm 14935 6768 164 K83H, A112D Endolysin Enterobacteria phage T4 1.5 yes HCl 10 mM 64.6 KCl 0.15 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0, 6.0 1L63, 2LZM 50.93111080593533, 33.031999588012695, 32.82888910505507, 29.41199951171875 1854726 10.1021/bi00243a015 1991 ProTherm 298 161 164 L84M Endolysin Enterobacteria phage T4 2.5 110.0 -4.9 Unknown 60.4 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 0.1 M CD Thermal 5.42 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 18.47125005722046, 17.223750114440918 in pocket 8901549 10.1073/pnas.93.22.12155 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6769 161 164 L84M Endolysin Enterobacteria phage T4 2.5 1.9 Unknown Acetic acid,Sodium acetate 1.4 mM,8.6 mM 65.3 NaCl 0.1 M CD Thermal 5.42 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 18.47125005722046, 17.223750114440918 in pocket 8901549 10.1073/pnas.93.22.12155 1996 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 2023 1129 164 L84A Endolysin Enterobacteria phage T4 101.0 -10.5 Yes(80%) 2.0 54.8 acetic acid, sodium acetate 1.4 mM, 8.6 mM Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 18.47125005722046, 17.223750114440918 in pocket 10545167 10.1021/bi9915519 1999 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S499.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 3144 1129 164 L84A Endolysin Enterobacteria phage T4 1.8 67.0 -13.4 Unknown 38.3 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 18.47125005722046, 17.223750114440918 in pocket 9514271 10.1002/pro.5560070117 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6790 1129 164 L84A Endolysin Enterobacteria phage T4 3.7 Yes(80%) 2.0 acetic acid, sodium acetate 1.4 mM, 8.6 mM 65.3 Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 18.47125005722046, 17.223750114440918 in pocket 10545167 10.1021/bi9915519 1999 ProTherm khan_protherm_data_mapped.csv 7578 1129 164 L84A Endolysin Enterobacteria phage T4 1.8 3.9 Unknown Potassium phosphate 20 mM 51.65 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 18.47125005722046, 17.223750114440918 in pocket 9514271 10.1002/pro.5560070117 1998 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14742 6900 164 L84M, L91M, L99M Endolysin Enterobacteria phage T4 yes 56.3 Sodium acetate,Acetic acid, 8.6 mM,1.4 mM, NaCl 0.10 M DSC Thermal 5.42 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 7.0, 8.0 1L63, 2LZM 18.47125005722046, 15.762500047683716, 14.700000047683716, 17.223750114440918, 13.31374990940094, 10.94999985396862 in pocket 10556025 10.1006/jmbi.1999.3220 1999 ProTherm 14743 6901 164 L84M, L91M, L99M, L118M, L121M Endolysin Enterobacteria phage T4 yes 53.0 Sodium acetate,Acetic acid, 8.6 mM,1.4 mM, NaCl 0.10 M DSC Thermal 5.42 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 7.0, 8.0, 7.0, 6.0 1L63, 2LZM 18.47125005722046, 15.762500047683716, 14.700000047683716, 19.833750009536743, 17.826250076293945, 17.223750114440918, 13.31374990940094, 10.94999985396862, 19.727499961853027, 18.857499837875366 in pocket 10556025 10.1006/jmbi.1999.3220 1999 ProTherm 14744 6902 164 L84M, L91M, L99M, L118M, L121M, L133M, F153M Endolysin Enterobacteria phage T4 yes 50.7 Sodium acetate,Acetic acid, 8.6 mM,1.4 mM, NaCl 0.10 M DSC Thermal 5.42 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 7.0, 8.0, 7.0, 6.0, 7.0, 7.0 1L63, 2LZM 18.47125005722046, 15.762500047683716, 14.700000047683716, 19.833750009536743, 17.826250076293945, 17.339999794960022, 18.75727298042991, 17.223750114440918, 13.31374990940094, 10.94999985396862, 19.727499961853027, 18.857499837875366, 14.184999942779541, 15.220908858559348 in pocket 10556025 10.1006/jmbi.1999.3220 1999 ProTherm 14745 6903 164 L84M, L91M, L99M, L118M, L121M, V111M, L133M Endolysin Enterobacteria phage T4 yes 53.4 Sodium acetate,Acetic acid, 8.6 mM,1.4 mM, NaCl 0.10 M DSC Thermal 5.42 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 7.0, 8.0, 8.0, 7.0, 6.0, 7.0 1L63, 2LZM 18.47125005722046, 15.762500047683716, 14.700000047683716, 21.174285616193497, 19.833750009536743, 17.826250076293945, 17.339999794960022, 17.223750114440918, 13.31374990940094, 10.94999985396862, 17.62571430206299, 19.727499961853027, 18.857499837875366, 14.184999942779541 in pocket 10556025 10.1006/jmbi.1999.3220 1999 ProTherm 14746 6904 164 L84M, L91M, L99M, L118M, L121M, L133M, F153M, V87M, V111M Endolysin Enterobacteria phage T4 yes 47.6 Sodium acetate,Acetic acid, 8.6 mM,1.4 mM, NaCl 0.10 M DSC Thermal 5.42 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 6.0, 7.0, 8.0, 8.0, 7.0, 6.0, 7.0, 7.0 1L63, 2LZM 18.47125005722046, 17.89714309147426, 15.762500047683716, 14.700000047683716, 21.174285616193497, 19.833750009536743, 17.826250076293945, 17.339999794960022, 18.75727298042991, 17.223750114440918, 16.339999880109513, 13.31374990940094, 10.94999985396862, 17.62571430206299, 19.727499961853027, 18.857499837875366, 14.184999942779541, 15.220908858559348 in pocket 10556025 10.1006/jmbi.1999.3220 1999 ProTherm 2791 1452 164 K85A Endolysin Enterobacteria phage T4 126.0 -1.0 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 27.940000004238552, 28.05000008477105 19384988 10.1002/pro.94 2009 ProTherm 2812 1452 164 K85A Endolysin Enterobacteria phage T4 134.0 0.9 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 27.940000004238552, 28.05000008477105 19384988 10.1002/pro.94 2009 ProTherm 7157 1452 164 K85A Endolysin Enterobacteria phage T4 2.5 0.6 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 58.0 CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 27.940000004238552, 28.05000008477105 19384988 10.1002/pro.94 2009 ProTherm 7991 1452 164 K85A Endolysin Enterobacteria phage T4 1.8 -0.1 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 44.0 CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 27.940000004238552, 28.05000008477105 19384988 10.1002/pro.94 2009 ProTherm 16137 7606 164 K85A, R96H Endolysin Enterobacteria phage T4 122.0 -9.8 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 6.0 1L63, 2LZM 27.940000004238552, 19.399999705227938, 28.05000008477105, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 16139 7606 164 K85A, R96H Endolysin Enterobacteria phage T4 109.0 -8.3 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 6.0 1L63, 2LZM 27.940000004238552, 19.399999705227938, 28.05000008477105, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 16761 7606 164 K85A, R96H Endolysin Enterobacteria phage T4 2.5 3.6 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 58.0 CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 6.0 1L63, 2LZM 27.940000004238552, 19.399999705227938, 28.05000008477105, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 16795 7606 164 K85A, R96H Endolysin Enterobacteria phage T4 1.8 3.5 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 44.0 CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 6.0 1L63, 2LZM 27.940000004238552, 19.399999705227938, 28.05000008477105, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 830 508 164 P86A Endolysin Enterobacteria phage T4 -2.0 yes 40.0 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 24.612857001168386, 22.992856979370117 3277275 10.1126/science.3277275 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 2997 508 164 P86A Endolysin Enterobacteria phage T4 -1.3 yes 40.6 phosphate 50 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 24.612857001168386, 22.992856979370117 7074100 10.1021/bi00535a054 1982 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4657 508 164 P86A Endolysin Enterobacteria phage T4 -1.3 yes 2.0 40.6 Phosphate buffer 50 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 24.612857001168386, 22.992856979370117 1737005 10.1021/bi00120a025 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 13902 508 164 P86A Endolysin Enterobacteria phage T4 2.49 17.8 yes 2.0 Phosphate buffer 50 mM 12.0 CD GdnHCl 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 24.612857001168386, 22.992856979370117 1737005 10.1021/bi00120a025 1992 ProTherm 831 509 164 P86R Endolysin Enterobacteria phage T4 -2.0 yes 40.0 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 24.612857001168386, 22.992856979370117 3277275 10.1126/science.3277275 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 840 509 164 P86R Endolysin Enterobacteria phage T4 -1.0 yes 62.0 Unknown KCl 0.2 M CD Thermal 4.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 24.612857001168386, 22.992856979370117 3277275 10.1126/science.3277275 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 843 509 164 P86R Endolysin Enterobacteria phage T4 -3.0 yes 63.0 Unknown KCl 0.2 M CD Thermal 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 24.612857001168386, 22.992856979370117 3277275 10.1126/science.3277275 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 832 510 164 P86D Endolysin Enterobacteria phage T4 0.0 yes 42.0 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 24.612857001168386, 22.992856979370117 3277275 10.1126/science.3277275 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 841 510 164 P86D Endolysin Enterobacteria phage T4 0.0 yes 63.0 Unknown KCl 0.2 M CD Thermal 4.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 24.612857001168386, 22.992856979370117 3277275 10.1126/science.3277275 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 844 510 164 P86D Endolysin Enterobacteria phage T4 -1.0 yes 65.0 Unknown KCl 0.2 M CD Thermal 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 24.612857001168386, 22.992856979370117 3277275 10.1126/science.3277275 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 833 511 164 P86C Endolysin Enterobacteria phage T4 -1.0 yes 41.0 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 24.612857001168386, 22.992856979370117 3277275 10.1126/science.3277275 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 834 512 164 P86G Endolysin Enterobacteria phage T4 -2.0 yes 40.0 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 24.612857001168386, 22.992856979370117 3277275 10.1126/science.3277275 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 842 512 164 P86G Endolysin Enterobacteria phage T4 -1.0 yes 62.0 Unknown KCl 0.2 M CD Thermal 4.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 24.612857001168386, 22.992856979370117 3277275 10.1126/science.3277275 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 12611 512 164 P86G Endolysin Enterobacteria phage T4 5.3 1.91 Unknown imidazole,MOPS, 0.05 M,0.05 M, 22.0 Gel electrophoresis Urea 7.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 24.612857001168386, 22.992856979370117 1988046 10.1021/bi00216a038 1991 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 835 513 164 P86H Endolysin Enterobacteria phage T4 -2.0 yes 40.0 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 24.612857001168386, 22.992856979370117 3277275 10.1126/science.3277275 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 845 513 164 P86H Endolysin Enterobacteria phage T4 -4.0 yes 62.0 Unknown KCl 0.2 M CD Thermal 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 24.612857001168386, 22.992856979370117 3277275 10.1126/science.3277275 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 836 514 164 P86I Endolysin Enterobacteria phage T4 -2.0 yes 40.0 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 24.612857001168386, 22.992856979370117 3277275 10.1126/science.3277275 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 837 515 164 P86L Endolysin Enterobacteria phage T4 -2.0 yes 40.0 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 24.612857001168386, 22.992856979370117 3277275 10.1126/science.3277275 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 838 516 164 P86S Endolysin Enterobacteria phage T4 -1.0 yes 41.0 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 24.612857001168386, 22.992856979370117 3277275 10.1126/science.3277275 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 839 517 164 P86T Endolysin Enterobacteria phage T4 -1.0 yes 41.0 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 24.612857001168386, 22.992856979370117 3277275 10.1126/science.3277275 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 425 239 164 V87T Endolysin Enterobacteria phage T4 105.0 -4.55 yes 47.0 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 17.89714309147426, 16.339999880109513 8218201 10.1021/bi00093a013 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7594 239 164 V87T Endolysin Enterobacteria phage T4 1.6 yes Potassium phosphate 20 mM 51.55 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 17.89714309147426, 16.339999880109513 8218201 10.1021/bi00093a013 1993 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1422 806 164 V87I Endolysin Enterobacteria phage T4 127.0 -0.8 Unknown 64.7 sodium chloride, acetic acid, sodium acetate 0.10 M, 1.4 mM, 8.6 mM CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 17.89714309147426, 16.339999880109513 12963380 10.1016/s0022-2836(03)00856-8 2003 ProTherm 7078 806 164 V87I Endolysin Enterobacteria phage T4 2.5 0.3 Unknown sodium chloride, acetic acid, sodium acetate 0.10 M, 1.4 mM, 8.6 mM 61.0 CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 17.89714309147426, 16.339999880109513 12963380 10.1016/s0022-2836(03)00856-8 2003 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 2024 1130 164 V87A Endolysin Enterobacteria phage T4 127.0 -4.3 Yes(80%) 2.0 61.0 acetic acid, sodium acetate 1.4 mM, 8.6 mM Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 17.89714309147426, 16.339999880109513 10545167 10.1021/bi9915519 1999 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S499.csv, EASE-MM_S1676.csv 3132 1130 164 V87A Endolysin Enterobacteria phage T4 1.8 102.0 -4.9 Unknown 46.8 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 17.89714309147426, 16.339999880109513 9514271 10.1002/pro.5560070117 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6791 1130 164 V87A Endolysin Enterobacteria phage T4 1.5 Yes(80%) 2.0 acetic acid, sodium acetate 1.4 mM, 8.6 mM 65.3 Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 17.89714309147426, 16.339999880109513 10545167 10.1021/bi9915519 1999 ProTherm khan_protherm_data_mapped.csv 7566 1130 164 V87A Endolysin Enterobacteria phage T4 1.8 1.7 Unknown Potassium phosphate 20 mM 51.65 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 17.89714309147426, 16.339999880109513 9514271 10.1002/pro.5560070117 1998 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 10024 1130 164 V87A Endolysin Enterobacteria phage T4 2.8 12.1 2.5 Unknown Potassium phosphate 20 mM 25.0 NaCl 100 mM CD Urea 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 17.89714309147426, 16.339999880109513 17400925 10.1110/ps.062632807 2007 ProTherm SAAFEC_S1262.csv 2042 1142 164 V87M Endolysin Enterobacteria phage T4 113.0 -6.3 Yes(80%) 2.0 59.0 acetic acid, sodium acetate 1.4 mM, 8.6 mM Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 17.89714309147426, 16.339999880109513 10545167 10.1021/bi9915519 1999 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, EASE-MM_S1676.csv, PON-TStab_dataset.csv, STRUM_Q306.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S499.csv 6809 1142 164 V87M Endolysin Enterobacteria phage T4 2.3 Yes(80%) 2.0 acetic acid, sodium acetate 1.4 mM, 8.6 mM 65.3 Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 17.89714309147426, 16.339999880109513 10545167 10.1021/bi9915519 1999 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 2792 1453 164 D89A Endolysin Enterobacteria phage T4 133.0 -1.3 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 20.179999947547913, 19.421249866485596 19384988 10.1002/pro.94 2009 ProTherm 2813 1453 164 D89A Endolysin Enterobacteria phage T4 135.0 -1.3 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 20.179999947547913, 19.421249866485596 19384988 10.1002/pro.94 2009 ProTherm 7158 1453 164 D89A Endolysin Enterobacteria phage T4 2.5 0.5 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 58.0 CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 20.179999947547913, 19.421249866485596 19384988 10.1002/pro.94 2009 ProTherm 7992 1453 164 D89A Endolysin Enterobacteria phage T4 1.8 0.7 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 44.0 CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 20.179999947547913, 19.421249866485596 19384988 10.1002/pro.94 2009 ProTherm 16138 7607 164 D89A, R96H Endolysin Enterobacteria phage T4 119.0 -10.2 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 6.0 1L63, 2LZM 20.179999947547913, 19.399999705227938, 19.421249866485596, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 16140 7607 164 D89A, R96H Endolysin Enterobacteria phage T4 87.0 -11.2 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 6.0 1L63, 2LZM 20.179999947547913, 19.399999705227938, 19.421249866485596, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 16762 7607 164 D89A, R96H Endolysin Enterobacteria phage T4 2.5 3.8 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 58.0 CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 6.0 1L63, 2LZM 20.179999947547913, 19.399999705227938, 19.421249866485596, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 16796 7607 164 D89A, R96H Endolysin Enterobacteria phage T4 1.8 4.3 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 44.0 CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 6.0 1L63, 2LZM 20.179999947547913, 19.399999705227938, 19.421249866485596, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 3415 1776 164 S90H Endolysin Enterobacteria phage T4 72.0 -4.1 yes 34.4 HCl 10 mM KCl 0.15 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 14.875, 12.076666514078775 1854726 10.1021/bi00243a015 1991 ProTherm AUTOMUTE_S1962.csv, Broom_S605.csv, Saraboji_S2204.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3416 1776 164 S90H Endolysin Enterobacteria phage T4 128.0 -2.7 yes 62.7 acetate 10 mM KCl 0.15 M CD Thermal 5.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 14.875, 12.076666514078775 1854726 10.1021/bi00243a015 1991 ProTherm AUTOMUTE_S1962.csv, Broom_S605.csv, Saraboji_S2204.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3417 1776 164 S90H Endolysin Enterobacteria phage T4 117.0 -2.9 yes 60.1 Potassium phosphate 10 mM KCl 0.15 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 14.875, 12.076666514078775 1854726 10.1021/bi00243a015 1991 ProTherm AUTOMUTE_S1962.csv, Broom_S605.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S1791.csv 6767 1776 164 S90H Endolysin Enterobacteria phage T4 1.1 yes acetate 10 mM 65.4 KCl 0.15 M CD Thermal 5.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 14.875, 12.076666514078775 1854726 10.1021/bi00243a015 1991 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 7039 1776 164 S90H Endolysin Enterobacteria phage T4 1.1 yes Potassium phosphate 10 mM 63.0 KCl 0.15 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 14.875, 12.076666514078775 1854726 10.1021/bi00243a015 1991 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 8426 1776 164 S90H Endolysin Enterobacteria phage T4 1.0 yes HCl 10 mM 28.5 KCl 0.15 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 14.875, 12.076666514078775 1854726 10.1021/bi00243a015 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14542 6767 164 S90H, Q122D Endolysin Enterobacteria phage T4 67.0 -5.8 yes 32.7 HCl 10 mM KCl 0.15 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0, 3.0 1L63, 2LZM 14.875, 39.32111104329427, 12.076666514078775, 31.825555483500164 1854726 10.1021/bi00243a015 1991 ProTherm 14543 6767 164 S90H, Q122D Endolysin Enterobacteria phage T4 128.0 -4.1 yes 61.3 HCl 10 mM KCl 0.15 M CD Thermal 5.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0, 3.0 1L63, 2LZM 14.875, 39.32111104329427, 12.076666514078775, 31.825555483500164 1854726 10.1021/bi00243a015 1991 ProTherm 14544 6767 164 S90H, Q122D Endolysin Enterobacteria phage T4 116.0 -5.7 yes 57.3 HCl 10 mM KCl 0.15 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0, 3.0 1L63, 2LZM 14.875, 39.32111104329427, 12.076666514078775, 31.825555483500164 1854726 10.1021/bi00243a015 1991 ProTherm 14930 6767 164 S90H, Q122D Endolysin Enterobacteria phage T4 1.4 yes HCl 10 mM 64.6 KCl 0.15 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0, 3.0 1L63, 2LZM 14.875, 39.32111104329427, 12.076666514078775, 31.825555483500164 1854726 10.1021/bi00243a015 1991 ProTherm 14931 6767 164 S90H, Q122D Endolysin Enterobacteria phage T4 1.6 yes HCl 10 mM 64.6 KCl 0.15 M CD Thermal 5.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0, 3.0 1L63, 2LZM 14.875, 39.32111104329427, 12.076666514078775, 31.825555483500164 1854726 10.1021/bi00243a015 1991 ProTherm 14932 6767 164 S90H, Q122D Endolysin Enterobacteria phage T4 2.2 yes HCl 10 mM 64.6 KCl 0.15 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0, 3.0 1L63, 2LZM 14.875, 39.32111104329427, 12.076666514078775, 31.825555483500164 1854726 10.1021/bi00243a015 1991 ProTherm 299 162 164 L91M Endolysin Enterobacteria phage T4 2.5 125.0 -2.0 Unknown 63.3 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 0.1 M CD Thermal 5.42 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 15.762500047683716, 13.31374990940094 8901549 10.1073/pnas.93.22.12155 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6770 162 164 L91M Endolysin Enterobacteria phage T4 2.5 0.8 Unknown Acetic acid,Sodium acetate 1.4 mM,8.6 mM 65.3 NaCl 0.1 M CD Thermal 5.42 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 15.762500047683716, 13.31374990940094 8901549 10.1073/pnas.93.22.12155 1996 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 2025 1131 164 L91A Endolysin Enterobacteria phage T4 113.0 -7.4 Yes(80%) 2.0 57.9 acetic acid, sodium acetate 1.4 mM, 8.6 mM Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 15.762500047683716, 13.31374990940094 10545167 10.1021/bi9915519 1999 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, EASE-MM_S1676.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S499.csv 3145 1131 164 L91A Endolysin Enterobacteria phage T4 1.8 85.0 -9.7 Unknown 42.0 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 15.762500047683716, 13.31374990940094 9514271 10.1002/pro.5560070117 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6792 1131 164 L91A Endolysin Enterobacteria phage T4 2.6 Yes(80%) 2.0 acetic acid, sodium acetate 1.4 mM, 8.6 mM 65.3 Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 15.762500047683716, 13.31374990940094 10545167 10.1021/bi9915519 1999 ProTherm khan_protherm_data_mapped.csv 7579 1131 164 L91A Endolysin Enterobacteria phage T4 1.8 3.1 Unknown Potassium phosphate 20 mM 51.65 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 15.762500047683716, 13.31374990940094 9514271 10.1002/pro.5560070117 1998 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 4055 2066 164 L91P Endolysin Enterobacteria phage T4 -34.3 no 30.7 Potassium phosphate 10 mM KCl 0.15 M CD Thermal 7.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 15.762500047683716, 13.31374990940094 8845764 10.1002/pro.5560050419 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 11099 2066 164 L91P Endolysin Enterobacteria phage T4 2.09 10.98 5.57 2.67 no Potassium phosphate 10 mM 25.0 KCl 0.15 M CD Urea 7.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 15.762500047683716, 13.31374990940094 8845764 10.1002/pro.5560050419 1996 ProTherm 12612 2066 164 L91P Endolysin Enterobacteria phage T4 2.2 8.13 Unknown imidazole,MOPS, 0.05 M,0.05 M, 22.0 Gel electrophoresis Urea 7.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 15.762500047683716, 13.31374990940094 1988046 10.1021/bi00216a038 1991 ProTherm 819 504 164 D92N Endolysin Enterobacteria phage T4 -0.3 yes 39.2 HCl 0.01 N KCl 200 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 16.792499899864197, 17.973750233650208 1911773 10.1021/bi00105a002 1991 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 824 504 164 D92N Endolysin Enterobacteria phage T4 -3.7 yes 58.7 HCl 0.01 N KCl 200 mM CD Thermal 6.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 16.792499899864197, 17.973750233650208 1911773 10.1021/bi00105a002 1991 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7063 504 164 D92N Endolysin Enterobacteria phage T4 1.4 yes HCl 0.01 N 62.4 KCl 200 mM CD Thermal 6.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 16.792499899864197, 17.973750233650208 1911773 10.1021/bi00105a002 1991 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, potapov_with_uniprot_mapping.csv 8158 504 164 D92N Endolysin Enterobacteria phage T4 0.1 yes HCl 0.01 N 39.5 KCl 200 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 16.792499899864197, 17.973750233650208 1911773 10.1021/bi00105a002 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 195 101 164 A93T Endolysin Enterobacteria phage T4 3.5 138.0 0.13 Unknown 65.28 Sodium acetate 10 mM NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 16.87799987792969, 18.376000213623048 7507755 10.1002/pro.5560021221 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 207 101 164 A93T Endolysin Enterobacteria phage T4 3.5 138.0 0.16 Unknown 62.35 Potassium phosphate 0.01 M KCl 0.15 M CD Thermal 6.78 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 16.87799987792969, 18.376000213623048 7507755 10.1002/pro.5560021221 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 1228 101 164 A93T Endolysin Enterobacteria phage T4 0.13 yes 65.2 Sodium acetate 10 mM NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 16.87799987792969, 18.376000213623048 8298466 10.1002/pro.5560021222 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6824 101 164 A93T Endolysin Enterobacteria phage T4 3.5 -0.06 Unknown Sodium acetate 10 mM 65.15 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 16.87799987792969, 18.376000213623048 7507755 10.1002/pro.5560021221 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 420 234 164 A93S Endolysin Enterobacteria phage T4 112.0 -0.52 yes 51.03 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 16.87799987792969, 18.376000213623048 8218201 10.1021/bi00093a013 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7589 234 164 A93S Endolysin Enterobacteria phage T4 0.2 yes Potassium phosphate 20 mM 51.55 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 16.87799987792969, 18.376000213623048 8218201 10.1021/bi00093a013 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 788 480 164 A93P Endolysin Enterobacteria phage T4 93.0 0.4 yes 42.3 H3PO4,HCl, 10 mM,10 mM, KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 16.87799987792969, 18.376000213623048 1457724 10.1002/bip.360321103 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 793 480 164 A93P Endolysin Enterobacteria phage T4 121.0 0.2 yes 64.9 Potassium phosphate 10 mM KCl 0.15 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 16.87799987792969, 18.376000213623048 1457724 10.1002/bip.360321103 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 891 480 164 A93P Endolysin Enterobacteria phage T4 yes 38.8 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 16.87799987792969, 18.376000213623048 1737020 10.1021/bi00121a009 1992 ProTherm 894 480 164 A93P Endolysin Enterobacteria phage T4 yes 46.2 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 16.87799987792969, 18.376000213623048 1737020 10.1021/bi00121a009 1992 ProTherm 897 480 164 A93P Endolysin Enterobacteria phage T4 yes 53.6 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 16.87799987792969, 18.376000213623048 1737020 10.1021/bi00121a009 1992 ProTherm 7002 480 164 A93P Endolysin Enterobacteria phage T4 -0.1 yes Potassium phosphate 10 mM 64.7 KCl 0.15 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 16.87799987792969, 18.376000213623048 1457724 10.1002/bip.360321103 1992 ProTherm capriotti_S1615_map.csv 7329 480 164 A93P Endolysin Enterobacteria phage T4 2.42 -1.1 yes Potassium phosphate 20 mM 53.6 KCl 25 mM DSC Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 16.87799987792969, 18.376000213623048 1737020 10.1021/bi00121a009 1992 ProTherm capriotti_S1615_map.csv 7847 480 164 A93P Endolysin Enterobacteria phage T4 2.42 -0.51 yes Potassium phosphate 20 mM 46.2 KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 16.87799987792969, 18.376000213623048 1737020 10.1021/bi00121a009 1992 ProTherm capriotti_S1615_map.csv 8049 480 164 A93P Endolysin Enterobacteria phage T4 -0.1 yes H3PO4,HCl 10 mM,10 mM 41.9 KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 16.87799987792969, 18.376000213623048 1457724 10.1002/bip.360321103 1992 ProTherm capriotti_S1615_map.csv 8211 480 164 A93P Endolysin Enterobacteria phage T4 2.42 -0.03 yes Potassium phosphate 20 mM 38.8 KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 16.87799987792969, 18.376000213623048 1737020 10.1021/bi00121a009 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 3133 1678 164 V94A Endolysin Enterobacteria phage T4 1.8 94.0 -5.0 Unknown 46.7 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 16.53285707746233, 13.001428740365165 9514271 10.1002/pro.5560070117 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7567 1678 164 V94A Endolysin Enterobacteria phage T4 1.8 1.8 Unknown Potassium phosphate 20 mM 51.65 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 16.53285707746233, 13.001428740365165 9514271 10.1002/pro.5560070117 1998 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 161 94 164 R96H Endolysin Enterobacteria phage T4 2.66 48.2 59.29 yes 23.44 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 2665807 10.1021/bi00435a024 1989 ProTherm 162 94 164 R96H Endolysin Enterobacteria phage T4 3.23 56.1 65.64 yes 23.12 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 2665807 10.1021/bi00435a024 1989 ProTherm 163 94 164 R96H Endolysin Enterobacteria phage T4 2.9 47.3 58.18 yes 22.53 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 2665807 10.1021/bi00435a024 1989 ProTherm HotMuSiC_S1626.csv 164 94 164 R96H Endolysin Enterobacteria phage T4 3.11 59.8 69.97 yes 23.67 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 2665807 10.1021/bi00435a024 1989 ProTherm 165 94 164 R96H Endolysin Enterobacteria phage T4 2.67 50.9 55.48 yes 22.64 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 2665807 10.1021/bi00435a024 1989 ProTherm 166 94 164 R96H Endolysin Enterobacteria phage T4 3.17 56.8 69.86 yes 23.49 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 2665807 10.1021/bi00435a024 1989 ProTherm 167 94 164 R96H Endolysin Enterobacteria phage T4 3.65 58.0 68.44 yes 24.31 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.1 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 2665807 10.1021/bi00435a024 1989 ProTherm 168 94 164 R96H Endolysin Enterobacteria phage T4 3.01 54.0 63.72 yes 24.31 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.1 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 2665807 10.1021/bi00435a024 1989 ProTherm 169 94 164 R96H Endolysin Enterobacteria phage T4 3.27 69.0 72.45 yes 26.81 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.2 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 2665807 10.1021/bi00435a024 1989 ProTherm 170 94 164 R96H Endolysin Enterobacteria phage T4 3.19 70.7 74.24 yes 26.95 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.2 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 2665807 10.1021/bi00435a024 1989 ProTherm 171 94 164 R96H Endolysin Enterobacteria phage T4 2.81 72.6 72.6 yes 27.56 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.2 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 2665807 10.1021/bi00435a024 1989 ProTherm 172 94 164 R96H Endolysin Enterobacteria phage T4 2.88 64.7 73.11 yes 29.35 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.34 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 2665807 10.1021/bi00435a024 1989 ProTherm 173 94 164 R96H Endolysin Enterobacteria phage T4 2.67 67.3 70.67 yes 29.93 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.34 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 2665807 10.1021/bi00435a024 1989 ProTherm 174 94 164 R96H Endolysin Enterobacteria phage T4 2.69 75.7 77.97 yes 30.83 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 2665807 10.1021/bi00435a024 1989 ProTherm 175 94 164 R96H Endolysin Enterobacteria phage T4 3.3 72.0 73.44 yes 30.63 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 2665807 10.1021/bi00435a024 1989 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 176 94 164 R96H Endolysin Enterobacteria phage T4 2.78 72.9 72.9 yes 31.32 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 2665807 10.1021/bi00435a024 1989 ProTherm 177 94 164 R96H Endolysin Enterobacteria phage T4 3.33 75.5 75.5 yes 32.83 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 2665807 10.1021/bi00435a024 1989 ProTherm 178 94 164 R96H Endolysin Enterobacteria phage T4 2.79 79.3 73.75 yes 33.3 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 2665807 10.1021/bi00435a024 1989 ProTherm 179 94 164 R96H Endolysin Enterobacteria phage T4 2.54 73.7 70.75 yes 34.19 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 2665807 10.1021/bi00435a024 1989 ProTherm 180 94 164 R96H Endolysin Enterobacteria phage T4 2.36 95.4 87.77 yes 36.99 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 2665807 10.1021/bi00435a024 1989 ProTherm 181 94 164 R96H Endolysin Enterobacteria phage T4 1.86 92.6 84.27 yes 37.44 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 2665807 10.1021/bi00435a024 1989 ProTherm 182 94 164 R96H Endolysin Enterobacteria phage T4 2.49 92.6 83.34 yes 37.41 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 2665807 10.1021/bi00435a024 1989 ProTherm 183 94 164 R96H Endolysin Enterobacteria phage T4 2.56 90.9 78.17 yes 37.63 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 2665807 10.1021/bi00435a024 1989 ProTherm 184 94 164 R96H Endolysin Enterobacteria phage T4 2.56 93.1 80.07 yes 37.85 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 2665807 10.1021/bi00435a024 1989 ProTherm 185 94 164 R96H Endolysin Enterobacteria phage T4 2.38 104.9 84.97 yes 40.8 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.84 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 2665807 10.1021/bi00435a024 1989 ProTherm 186 94 164 R96H Endolysin Enterobacteria phage T4 2.41 97.8 81.17 yes 41.08 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.84 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 2665807 10.1021/bi00435a024 1989 ProTherm 187 94 164 R96H Endolysin Enterobacteria phage T4 2.46 95.4 79.18 yes 41.51 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.84 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 2665807 10.1021/bi00435a024 1989 ProTherm 188 94 164 R96H Endolysin Enterobacteria phage T4 2.43 95.4 77.27 yes 41.31 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.84 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 2665807 10.1021/bi00435a024 1989 ProTherm 246 94 164 R96H Endolysin Enterobacteria phage T4 2.4 71.4 Unknown 46.85 Unknown CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 7306671 10.1002/bip.1981.360200921 1981 ProTherm 251 94 164 R96H Endolysin Enterobacteria phage T4 2.4 -14.0 Unknown 45.0 Unknown CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 7306671 10.1002/bip.1981.360200921 1981 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 478 94 164 R96H Endolysin Enterobacteria phage T4 -13.6 yes 43.2 Unknown NaCl 0.2 M CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 6726809 10.1016/0022-2836(84)90474-1 1984 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 481 94 164 R96H Endolysin Enterobacteria phage T4 3.3 -13.6 yes 43.2 Unknown NaCl 0.2 M CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 6726809 10.1016/0022-2836(84)90474-1 1984 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 620 94 164 R96H Endolysin Enterobacteria phage T4 -14.0 yes 37.6 HCl CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 3323816 10.1016/0076-6879(87)54093-9 1987 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 816 94 164 R96H Endolysin Enterobacteria phage T4 -7.0 yes 58.0 Unknown KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 3277175 10.1073/pnas.85.2.401 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 2784 94 164 R96H Endolysin Enterobacteria phage T4 121.0 -8.3 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 2805 94 164 R96H Endolysin Enterobacteria phage T4 113.0 -9.4 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 3031 94 164 R96H Endolysin Enterobacteria phage T4 -7.8 Unknown 57.7 Unknown CD Thermal 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 3689874 10.1002/bip.360261104 1987 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3425 94 164 R96H Endolysin Enterobacteria phage T4 2.96 53.2 63.1 -15.6 yes 23.15 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 2665807 10.1021/bi00435a024 1989 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q306.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3426 94 164 R96H Endolysin Enterobacteria phage T4 3.33 56.0 66.1 yes 24.31 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.1 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 2665807 10.1021/bi00435a024 1989 ProTherm 3427 94 164 R96H Endolysin Enterobacteria phage T4 3.09 70.8 73.16 -13.5 yes 27.11 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.2 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 2665807 10.1021/bi00435a024 1989 ProTherm AUTOMUTE_S1962.csv, EASE-MM_S543.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, Broom_S605.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3428 94 164 R96H Endolysin Enterobacteria phage T4 2.78 66.0 71.94 -13.3 yes 29.64 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.34 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 2665807 10.1021/bi00435a024 1989 ProTherm AUTOMUTE_S1962.csv, Broom_S605.csv, EASE-MM_S543.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3429 94 164 R96H Endolysin Enterobacteria phage T4 2.92 73.5 74.2 -12.8 yes 30.93 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 2665807 10.1021/bi00435a024 1989 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3430 94 164 R96H Endolysin Enterobacteria phage T4 2.89 76.2 73.4 11.6 yes 33.44 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 2665807 10.1021/bi00435a024 1989 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3431 94 164 R96H Endolysin Enterobacteria phage T4 2.37 92.9 82.68 -11.2 yes 37.46 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 2665807 10.1021/bi00435a024 1989 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3432 94 164 R96H Endolysin Enterobacteria phage T4 2.42 98.4 80.7 -10.5 yes 41.18 KH2PO4 20 mM KCl 25 mM DSC Thermal 2.84 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 2665807 10.1021/bi00435a024 1989 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6644 94 164 R96H Endolysin Enterobacteria phage T4 2.8 yes Unknown 70.0 KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 3277175 10.1073/pnas.85.2.401 1988 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 6765 94 164 R96H Endolysin Enterobacteria phage T4 2.82 Unknown Unknown 65.5 CD Thermal 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 3689874 10.1002/bip.360261104 1987 ProTherm capriotti_S1615_map.csv 7150 94 164 R96H Endolysin Enterobacteria phage T4 2.5 3.1 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 58.0 CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 7984 94 164 R96H Endolysin Enterobacteria phage T4 1.8 3.8 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 44.0 CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 2772 1434 164 R96K Endolysin Enterobacteria phage T4 138.0 -0.2 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 2793 1434 164 R96K Endolysin Enterobacteria phage T4 134.0 -0.7 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 7138 1434 164 R96K Endolysin Enterobacteria phage T4 2.5 0.0 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 58.0 CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 7972 1434 164 R96K Endolysin Enterobacteria phage T4 1.8 0.5 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 44.0 CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 2773 1435 164 R96Q Endolysin Enterobacteria phage T4 143.0 -1.4 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 2794 1435 164 R96Q Endolysin Enterobacteria phage T4 134.0 -1.2 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 7139 1435 164 R96Q Endolysin Enterobacteria phage T4 2.5 0.3 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 58.0 CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 7973 1435 164 R96Q Endolysin Enterobacteria phage T4 1.8 0.7 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 44.0 CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 2774 1436 164 R96A Endolysin Enterobacteria phage T4 117.0 -5.1 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 2795 1436 164 R96A Endolysin Enterobacteria phage T4 124.0 -4.3 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 7140 1436 164 R96A Endolysin Enterobacteria phage T4 2.5 2.0 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 58.0 CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 7974 1436 164 R96A Endolysin Enterobacteria phage T4 1.8 2.0 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 44.0 CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 2775 1437 164 R96V Endolysin Enterobacteria phage T4 113.0 -6.4 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 2796 1437 164 R96V Endolysin Enterobacteria phage T4 98.0 -4.8 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 7141 1437 164 R96V Endolysin Enterobacteria phage T4 2.5 2.4 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 58.0 CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 7975 1437 164 R96V Endolysin Enterobacteria phage T4 1.8 2.5 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 44.0 CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 2776 1438 164 R96S Endolysin Enterobacteria phage T4 118.0 -7.0 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 2797 1438 164 R96S Endolysin Enterobacteria phage T4 121.0 -6.6 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 7142 1438 164 R96S Endolysin Enterobacteria phage T4 2.5 2.6 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 58.0 CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 7976 1438 164 R96S Endolysin Enterobacteria phage T4 1.8 2.8 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 44.0 CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 2777 1439 164 R96E Endolysin Enterobacteria phage T4 133.0 -7.0 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 2798 1439 164 R96E Endolysin Enterobacteria phage T4 122.0 -4.1 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 7143 1439 164 R96E Endolysin Enterobacteria phage T4 2.5 2.5 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 58.0 CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 7977 1439 164 R96E Endolysin Enterobacteria phage T4 1.8 1.9 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 44.0 CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 2778 1440 164 R96G Endolysin Enterobacteria phage T4 120.0 -7.1 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 2799 1440 164 R96G Endolysin Enterobacteria phage T4 112.0 -7.5 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 7144 1440 164 R96G Endolysin Enterobacteria phage T4 2.5 2.6 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 58.0 CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 7978 1440 164 R96G Endolysin Enterobacteria phage T4 1.8 3.2 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 44.0 CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 2779 1441 164 R96M Endolysin Enterobacteria phage T4 114.0 -7.1 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 2800 1441 164 R96M Endolysin Enterobacteria phage T4 101.0 -5.2 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 7145 1441 164 R96M Endolysin Enterobacteria phage T4 2.5 2.7 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 58.0 CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 7979 1441 164 R96M Endolysin Enterobacteria phage T4 1.8 2.5 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 44.0 CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 2780 1442 164 R96T Endolysin Enterobacteria phage T4 124.0 -7.6 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 2801 1442 164 R96T Endolysin Enterobacteria phage T4 111.0 -7.2 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 7146 1442 164 R96T Endolysin Enterobacteria phage T4 2.5 2.8 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 58.0 CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 7980 1442 164 R96T Endolysin Enterobacteria phage T4 1.8 3.1 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 44.0 CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 2781 1443 164 R96C Endolysin Enterobacteria phage T4 100.0 -7.7 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 2802 1443 164 R96C Endolysin Enterobacteria phage T4 105.0 -6.6 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 3624 1443 164 R96C Endolysin Enterobacteria phage T4 -8.7 yes 27.7 Potassium phosphate 20 mM KCl 25 mM CD Thermal 2.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 1510962 10.1021/bi00149a004 1992 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3629 1443 164 R96C Endolysin Enterobacteria phage T4 yes 58.4 Potassium acetate 100 mM CD Thermal 5.3 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 1510962 10.1021/bi00149a004 1992 ProTherm Broom_S605.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 7147 1443 164 R96C Endolysin Enterobacteria phage T4 2.5 2.9 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 58.0 CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 7981 1443 164 R96C Endolysin Enterobacteria phage T4 1.8 2.9 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 44.0 CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 2782 1444 164 R96I Endolysin Enterobacteria phage T4 117.0 -7.9 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 2803 1444 164 R96I Endolysin Enterobacteria phage T4 94.0 -5.6 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 7148 1444 164 R96I Endolysin Enterobacteria phage T4 2.5 2.9 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 58.0 CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 7982 1444 164 R96I Endolysin Enterobacteria phage T4 1.8 2.8 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 44.0 CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 2783 1445 164 R96N Endolysin Enterobacteria phage T4 125.0 -8.0 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 2804 1445 164 R96N Endolysin Enterobacteria phage T4 116.0 -8.0 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 7149 1445 164 R96N Endolysin Enterobacteria phage T4 2.5 3.0 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 58.0 CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 7983 1445 164 R96N Endolysin Enterobacteria phage T4 1.8 3.3 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 44.0 CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 2785 1446 164 R96L Endolysin Enterobacteria phage T4 114.0 -8.6 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 2806 1446 164 R96L Endolysin Enterobacteria phage T4 88.0 -7.2 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 7151 1446 164 R96L Endolysin Enterobacteria phage T4 2.5 3.2 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 58.0 CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 7985 1446 164 R96L Endolysin Enterobacteria phage T4 1.8 3.2 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 44.0 CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 2786 1447 164 R96D Endolysin Enterobacteria phage T4 124.0 -9.5 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 2807 1447 164 R96D Endolysin Enterobacteria phage T4 120.0 -5.2 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 7152 1447 164 R96D Endolysin Enterobacteria phage T4 2.5 3.5 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 58.0 CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 7986 1447 164 R96D Endolysin Enterobacteria phage T4 1.8 2.3 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 44.0 CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 2787 1448 164 R96F Endolysin Enterobacteria phage T4 108.0 -11.5 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 2808 1448 164 R96F Endolysin Enterobacteria phage T4 73.0 -11.2 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 7153 1448 164 R96F Endolysin Enterobacteria phage T4 2.5 4.2 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 58.0 CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 7987 1448 164 R96F Endolysin Enterobacteria phage T4 1.8 4.2 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 44.0 CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 2788 1449 164 R96W Endolysin Enterobacteria phage T4 95.0 -12.8 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 2809 1449 164 R96W Endolysin Enterobacteria phage T4 73.0 -11.0 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 7154 1449 164 R96W Endolysin Enterobacteria phage T4 2.5 4.5 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 58.0 CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 7988 1449 164 R96W Endolysin Enterobacteria phage T4 1.8 4.2 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 44.0 CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 2789 1450 164 R96Y Endolysin Enterobacteria phage T4 99.0 -13.2 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 2810 1450 164 R96Y Endolysin Enterobacteria phage T4 73.0 -12.3 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 7155 1450 164 R96Y Endolysin Enterobacteria phage T4 2.5 4.7 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 58.0 CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 7989 1450 164 R96Y Endolysin Enterobacteria phage T4 1.8 4.5 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 44.0 CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 2790 1451 164 R96P Endolysin Enterobacteria phage T4 103.0 -15.5 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 2811 1451 164 R96P Endolysin Enterobacteria phage T4 85.0 -16.6 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 7156 1451 164 R96P Endolysin Enterobacteria phage T4 2.5 5.5 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 58.0 CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 7990 1451 164 R96P Endolysin Enterobacteria phage T4 1.8 6.0 Unknown Sodium chloride, Acetic acid, Sodium acetate 100 mM, 1.4 mM, 8.6 mM 44.0 CD Thermal 3.05 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 19.399999705227938, 19.36909090388905 19384988 10.1002/pro.94 2009 ProTherm 421 235 164 A98S Endolysin Enterobacteria phage T4 97.0 -7.47 yes 44.08 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.46400032043457, 11.706000232696534 8218201 10.1021/bi00093a013 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7590 235 164 A98S Endolysin Enterobacteria phage T4 2.5 yes Potassium phosphate 20 mM 51.55 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.46400032043457, 11.706000232696534 8218201 10.1021/bi00093a013 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 621 359 164 A98V Endolysin Enterobacteria phage T4 -13.0 yes 38.6 HCl CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.46400032043457, 11.706000232696534 3323816 10.1016/0076-6879(87)54093-9 1987 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 990 359 164 A98V Endolysin Enterobacteria phage T4 25.5 -14.8 yes 39.3 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.46400032043457, 11.706000232696534 1920439 10.1016/0022-2836(91)80079-a 1991 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3778 359 164 A98V Endolysin Enterobacteria phage T4 67.0 -9.2 yes 42.5 phosphoric acid,Potassium phosphate, 3 mM,17 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.46400032043457, 11.706000232696534 10623513 10.1006/jmbi.1999.3300 2000 ProTherm Broom_S605.csv, EASE-MM_S543.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8094 359 164 A98V Endolysin Enterobacteria phage T4 2.41 4.9 yes Potassium phosphate 20 mM 40.0 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.46400032043457, 11.706000232696534 1920439 10.1016/0022-2836(91)80079-a 1991 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 12614 359 164 A98V Endolysin Enterobacteria phage T4 3.8 5.02 Unknown imidazole,MOPS, 0.05 M,0.05 M, 22.0 Gel electrophoresis Urea 7.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.46400032043457, 11.706000232696534 1988046 10.1021/bi00216a038 1991 ProTherm SAAFEC_S1262.csv 3777 1960 164 A98C Endolysin Enterobacteria phage T4 105.0 -2.6 yes 49.1 phosphoric acid,Potassium phosphate, 3 mM,17 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.46400032043457, 11.706000232696534 10623513 10.1006/jmbi.1999.3300 2000 ProTherm STRUM_Q3421.csv, EASE-MM_S543.csv, PoPMuSiC-2.0_S2648.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3779 1961 164 A98L Endolysin Enterobacteria phage T4 49.0 -13.9 yes 37.8 phosphoric acid,Potassium phosphate, 3 mM,17 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.46400032043457, 11.706000232696534 10623513 10.1006/jmbi.1999.3300 2000 ProTherm STRUM_Q3421.csv, EASE-MM_S543.csv, PoPMuSiC-2.0_S2648.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3780 1962 164 A98I Endolysin Enterobacteria phage T4 41.0 -16.1 yes 35.6 phosphoric acid,Potassium phosphate, 3 mM,17 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.46400032043457, 11.706000232696534 10623513 10.1006/jmbi.1999.3300 2000 ProTherm EASE-MM_S543.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3781 1963 164 A98M Endolysin Enterobacteria phage T4 75.0 -9.3 yes 42.4 phosphoric acid,Potassium phosphate, 3 mM,17 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.46400032043457, 11.706000232696534 10623513 10.1006/jmbi.1999.3300 2000 ProTherm EASE-MM_S543.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3782 1964 164 A98F Endolysin Enterobacteria phage T4 18.0 -20.4 yes 31.3 phosphoric acid,Potassium phosphate, 3 mM,17 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.46400032043457, 11.706000232696534 10623513 10.1006/jmbi.1999.3300 2000 ProTherm EASE-MM_S543.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3783 1965 164 A98W Endolysin Enterobacteria phage T4 20.0 -19.3 yes 32.4 phosphoric acid,Potassium phosphate, 3 mM,17 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.46400032043457, 11.706000232696534 10623513 10.1006/jmbi.1999.3300 2000 ProTherm EASE-MM_S543.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 12613 5834 164 A98T Endolysin Enterobacteria phage T4 4.4 3.83 Unknown imidazole,MOPS, 0.05 M,0.05 M, 22.0 Gel electrophoresis Urea 7.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.46400032043457, 11.706000232696534 1988046 10.1021/bi00216a038 1991 ProTherm SAAFEC_S1262.csv 14577 6782 164 A98V, T152S Endolysin Enterobacteria phage T4 36.8 -13.9 yes 40.2 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 7.0 1L63, 2LZM 15.46400032043457, 14.934285708836146, 11.706000232696534, 14.574285643441337 1920439 10.1016/0022-2836(91)80079-a 1991 ProTherm 15113 6782 164 A98V, T152S Endolysin Enterobacteria phage T4 2.41 4.8 yes Potassium phosphate 20 mM 40.0 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 7.0 1L63, 2LZM 15.46400032043457, 14.934285708836146, 11.706000232696534, 14.574285643441337 1920439 10.1016/0022-2836(91)80079-a 1991 ProTherm 15489 6782 164 A98V, T152S Endolysin Enterobacteria phage T4 3.6 5.5 Unknown imidazole,MOPS, 0.05 M,0.05 M, 22.0 Gel electrophoresis Urea 7.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 7.0 1L63, 2LZM 15.46400032043457, 14.934285708836146, 11.706000232696534, 14.574285643441337 1988046 10.1021/bi00216a038 1991 ProTherm 14578 6783 164 A98V, V149C, T152S Endolysin Enterobacteria phage T4 74.3 -12.1 yes 42.0 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 8.0, 7.0 1L63, 2LZM 15.46400032043457, 15.521428653172084, 14.934285708836146, 11.706000232696534, 9.985714299338204, 14.574285643441337 1920439 10.1016/0022-2836(91)80079-a 1991 ProTherm 15114 6783 164 A98V, V149C, T152S Endolysin Enterobacteria phage T4 2.41 4.4 yes Potassium phosphate 20 mM 40.0 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 8.0, 7.0 1L63, 2LZM 15.46400032043457, 15.521428653172084, 14.934285708836146, 11.706000232696534, 9.985714299338204, 14.574285643441337 1920439 10.1016/0022-2836(91)80079-a 1991 ProTherm 14579 6784 164 A98V, V149I, T152S Endolysin Enterobacteria phage T4 69.2 -12.0 yes 42.1 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 8.0, 7.0 1L63, 2LZM 15.46400032043457, 15.521428653172084, 14.934285708836146, 11.706000232696534, 9.985714299338204, 14.574285643441337 1920439 10.1016/0022-2836(91)80079-a 1991 ProTherm 15115 6784 164 A98V, V149I, T152S Endolysin Enterobacteria phage T4 2.41 4.4 yes Potassium phosphate 20 mM 40.0 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 8.0, 7.0 1L63, 2LZM 15.46400032043457, 15.521428653172084, 14.934285708836146, 11.706000232696534, 9.985714299338204, 14.574285643441337 1920439 10.1016/0022-2836(91)80079-a 1991 ProTherm 41 41 164 L99A Endolysin Enterobacteria phage T4 2.5 79.6 -15.7 yes 36.1 Potassium phosphate 0.020 M KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 14.700000047683716, 10.94999985396862 1553543 10.1126/science.1553543 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 958 41 164 L99A Endolysin Enterobacteria phage T4 80.0 -15.7 yes 36.06 KH2PO4 20 mM KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 14.700000047683716, 10.94999985396862 8433369 10.1006/jmbi.1993.1077 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 968 41 164 L99A Endolysin Enterobacteria phage T4 110.0 -11.4 yes 53.48 KH2PO4 10 mM KCl 20 mM CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 14.700000047683716, 10.94999985396862 8433369 10.1006/jmbi.1993.1077 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 2026 41 164 L99A Endolysin Enterobacteria phage T4 104.0 -11.7 Yes(80%) 2.0 53.6 acetic acid, sodium acetate 1.4 mM, 8.6 mM Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 14.700000047683716, 10.94999985396862 10545167 10.1021/bi9915519 1999 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S499.csv, EASE-MM_S1676.csv 3824 41 164 L99A Endolysin Enterobacteria phage T4 76.0 -15.6 yes(>95%) 36.1 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 14.700000047683716, 10.94999985396862 10512706 10.1006/jmbi.1999.3102 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q306.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3827 41 164 L99A Endolysin Enterobacteria phage T4 101.0 -11.5 yes(>80%) 53.7 Sodium acetate 10 mM NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 14.700000047683716, 10.94999985396862 10512706 10.1006/jmbi.1999.3102 1999 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6793 41 164 L99A Endolysin Enterobacteria phage T4 4.1 Yes(80%) 2.0 acetic acid, sodium acetate 1.4 mM, 8.6 mM 65.3 Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 14.700000047683716, 10.94999985396862 10545167 10.1021/bi9915519 1999 ProTherm khan_protherm_data_mapped.csv 6816 41 164 L99A Endolysin Enterobacteria phage T4 4.0 yes(>80%) Sodium acetate 10 mM 65.2 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 14.700000047683716, 10.94999985396862 10512706 10.1006/jmbi.1999.3102 1999 ProTherm 6971 41 164 L99A Endolysin Enterobacteria phage T4 3.5 4.5 yes KH2PO4 10 mM 64.88 KCl 20 mM CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 14.700000047683716, 10.94999985396862 8433369 10.1006/jmbi.1993.1077 1993 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, potapov_with_uniprot_mapping.csv 7502 41 164 L99A Endolysin Enterobacteria phage T4 2.5 5.0 yes Potassium phosphate 0.020 M 51.8 KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 14.700000047683716, 10.94999985396862 1553543 10.1126/science.1553543 1992 ProTherm capriotti_S1615_map.csv 7509 41 164 L99A Endolysin Enterobacteria phage T4 2.5 5.0 yes KH2PO4 20 mM 51.76 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 14.700000047683716, 10.94999985396862 8433369 10.1006/jmbi.1993.1077 1993 ProTherm capriotti_S1615_map.csv 7521 41 164 L99A Endolysin Enterobacteria phage T4 4.6 yes(>95%) Potassium phosphate 20 mM 51.7 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 14.700000047683716, 10.94999985396862 10512706 10.1006/jmbi.1999.3102 1999 ProTherm 300 163 164 L99M Endolysin Enterobacteria phage T4 2.5 134.0 -1.3 Unknown 64.0 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 0.1 M CD Thermal 5.42 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 14.700000047683716, 10.94999985396862 8901549 10.1073/pnas.93.22.12155 1996 ProTherm HotMuSiC_S1626.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 961 163 164 L99M Endolysin Enterobacteria phage T4 116.0 -2.0 yes 49.76 KH2PO4 20 mM KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 14.700000047683716, 10.94999985396862 8433369 10.1006/jmbi.1993.1077 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 971 163 164 L99M Endolysin Enterobacteria phage T4 140.0 -1.5 yes 63.38 KH2PO4 10 mM KCl 20 mM CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 14.700000047683716, 10.94999985396862 8433369 10.1006/jmbi.1993.1077 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6771 163 164 L99M Endolysin Enterobacteria phage T4 2.5 0.4 Unknown Acetic acid,Sodium acetate 1.4 mM,8.6 mM 65.3 NaCl 0.1 M CD Thermal 5.42 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 14.700000047683716, 10.94999985396862 8901549 10.1073/pnas.93.22.12155 1996 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 6974 163 164 L99M Endolysin Enterobacteria phage T4 3.5 0.6 yes KH2PO4 10 mM 64.88 KCl 20 mM CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 14.700000047683716, 10.94999985396862 8433369 10.1006/jmbi.1993.1077 1993 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 7512 163 164 L99M Endolysin Enterobacteria phage T4 2.5 0.7 yes KH2PO4 20 mM 51.76 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 14.700000047683716, 10.94999985396862 8433369 10.1006/jmbi.1993.1077 1993 ProTherm capriotti_S1615_map.csv 959 573 164 L99V Endolysin Enterobacteria phage T4 101.0 -6.6 yes 45.16 KH2PO4 20 mM KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 14.700000047683716, 10.94999985396862 8433369 10.1006/jmbi.1993.1077 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 969 573 164 L99V Endolysin Enterobacteria phage T4 121.0 -5.2 yes 59.68 KH2PO4 10 mM KCl 20 mM CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 14.700000047683716, 10.94999985396862 8433369 10.1006/jmbi.1993.1077 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6972 573 164 L99V Endolysin Enterobacteria phage T4 3.5 2.0 yes KH2PO4 10 mM 64.88 KCl 20 mM CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 14.700000047683716, 10.94999985396862 8433369 10.1006/jmbi.1993.1077 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 7510 573 164 L99V Endolysin Enterobacteria phage T4 2.5 2.3 yes KH2PO4 20 mM 51.76 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 14.700000047683716, 10.94999985396862 8433369 10.1006/jmbi.1993.1077 1993 ProTherm capriotti_S1615_map.csv 960 574 164 L99I Endolysin Enterobacteria phage T4 107.0 -4.0 yes 47.76 KH2PO4 20 mM KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 14.700000047683716, 10.94999985396862 8433369 10.1006/jmbi.1993.1077 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 970 574 164 L99I Endolysin Enterobacteria phage T4 127.0 -3.7 yes 61.18 KH2PO4 10 mM KCl 20 mM CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 14.700000047683716, 10.94999985396862 8433369 10.1006/jmbi.1993.1077 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6973 574 164 L99I Endolysin Enterobacteria phage T4 3.5 1.5 yes KH2PO4 10 mM 64.88 KCl 20 mM CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 14.700000047683716, 10.94999985396862 8433369 10.1006/jmbi.1993.1077 1993 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 7511 574 164 L99I Endolysin Enterobacteria phage T4 2.5 1.4 yes KH2PO4 20 mM 51.76 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 14.700000047683716, 10.94999985396862 8433369 10.1006/jmbi.1993.1077 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 962 575 164 L99F Endolysin Enterobacteria phage T4 109.0 -1.1 yes 50.66 KH2PO4 20 mM KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 14.700000047683716, 10.94999985396862 8433369 10.1006/jmbi.1993.1077 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 972 575 164 L99F Endolysin Enterobacteria phage T4 126.0 -0.7 yes 64.18 KH2PO4 10 mM KCl 20 mM CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 14.700000047683716, 10.94999985396862 8433369 10.1006/jmbi.1993.1077 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6975 575 164 L99F Endolysin Enterobacteria phage T4 3.5 0.3 yes KH2PO4 10 mM 64.88 KCl 20 mM CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 14.700000047683716, 10.94999985396862 8433369 10.1006/jmbi.1993.1077 1993 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 7513 575 164 L99F Endolysin Enterobacteria phage T4 2.5 0.4 yes KH2PO4 20 mM 51.76 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 14.700000047683716, 10.94999985396862 8433369 10.1006/jmbi.1993.1077 1993 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 3825 1989 164 L99G Endolysin Enterobacteria phage T4 48.0 -29.2 yes(>95%) 22.5 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 14.700000047683716, 10.94999985396862 10512706 10.1006/jmbi.1999.3102 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3828 1989 164 L99G Endolysin Enterobacteria phage T4 74.0 -20.3 yes(>80%) 44.9 Sodium acetate 10 mM NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 14.700000047683716, 10.94999985396862 10512706 10.1006/jmbi.1999.3102 1999 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6817 1989 164 L99G Endolysin Enterobacteria phage T4 6.3 yes(>80%) Sodium acetate 10 mM 65.2 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 14.700000047683716, 10.94999985396862 10512706 10.1006/jmbi.1999.3102 1999 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv 7522 1989 164 L99G Endolysin Enterobacteria phage T4 7.4 yes(>95%) Potassium phosphate 20 mM 51.7 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 14.700000047683716, 10.94999985396862 10512706 10.1006/jmbi.1999.3102 1999 ProTherm 14440 6699 164 L99A, F153A Endolysin Enterobacteria phage T4 2.5 6.0 -41.8 yes 10.0 Potassium phosphate 0.020 M KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 7.0 1L63, 2LZM 14.700000047683716, 18.75727298042991, 10.94999985396862, 15.220908858559348 in pocket 1553543 10.1126/science.1553543 1992 ProTherm 14575 6699 164 L99A, F153A Endolysin Enterobacteria phage T4 6.0 -41.8 yes 9.86 KH2PO4 20 mM KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 7.0 1L63, 2LZM 14.700000047683716, 18.75727298042991, 10.94999985396862, 15.220908858559348 in pocket 8433369 10.1006/jmbi.1993.1077 1993 ProTherm 14576 6699 164 L99A, F153A Endolysin Enterobacteria phage T4 56.0 -22.8 yes 42.08 KH2PO4 10 mM KCl 20 mM CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 7.0 1L63, 2LZM 14.700000047683716, 18.75727298042991, 10.94999985396862, 15.220908858559348 in pocket 8433369 10.1006/jmbi.1993.1077 1993 ProTherm 14928 6699 164 L99A, F153A Endolysin Enterobacteria phage T4 3.5 6.9 yes KH2PO4 10 mM 64.88 KCl 20 mM CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 7.0 1L63, 2LZM 14.700000047683716, 18.75727298042991, 10.94999985396862, 15.220908858559348 in pocket 8433369 10.1006/jmbi.1993.1077 1993 ProTherm 15008 6699 164 L99A, F153A Endolysin Enterobacteria phage T4 2.5 8.3 yes KH2PO4 20 mM 51.76 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 7.0 1L63, 2LZM 14.700000047683716, 18.75727298042991, 10.94999985396862, 15.220908858559348 in pocket 8433369 10.1006/jmbi.1993.1077 1993 ProTherm 14493 6734 164 L99F, M102L Endolysin Enterobacteria phage T4 -2.34 yes 49.42 phosphate 20 mM KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 9.0 1L63, 2LZM 14.700000047683716, 17.96749985218048, 10.94999985396862, 13.190000236034393 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm 14502 6734 164 L99F, M102L Endolysin Enterobacteria phage T4 -2.21 yes 62.68 phosphate 10 mM KCl 0.2 M CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 9.0 1L63, 2LZM 14.700000047683716, 17.96749985218048, 10.94999985396862, 13.190000236034393 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm 14919 6734 164 L99F, M102L Endolysin Enterobacteria phage T4 0.75 yes phosphate 10 mM 64.89 KCl 0.2 M CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 9.0 1L63, 2LZM 14.700000047683716, 17.96749985218048, 10.94999985396862, 13.190000236034393 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm 14999 6734 164 L99F, M102L Endolysin Enterobacteria phage T4 0.71 yes phosphate 20 mM 51.76 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 9.0 1L63, 2LZM 14.700000047683716, 17.96749985218048, 10.94999985396862, 13.190000236034393 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm 14494 6735 164 L99F, V111I Endolysin Enterobacteria phage T4 -2.7 yes 49.06 phosphate 20 mM KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 8.0 1L63, 2LZM 14.700000047683716, 21.174285616193497, 10.94999985396862, 17.62571430206299 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm 14503 6735 164 L99F, V111I Endolysin Enterobacteria phage T4 -2.51 yes 62.38 phosphate 10 mM KCl 0.2 M CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 8.0 1L63, 2LZM 14.700000047683716, 21.174285616193497, 10.94999985396862, 17.62571430206299 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm 14920 6735 164 L99F, V111I Endolysin Enterobacteria phage T4 0.93 yes phosphate 10 mM 64.89 KCl 0.2 M CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 8.0 1L63, 2LZM 14.700000047683716, 21.174285616193497, 10.94999985396862, 17.62571430206299 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm 15000 6735 164 L99F, V111I Endolysin Enterobacteria phage T4 0.82 yes phosphate 20 mM 51.76 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 8.0 1L63, 2LZM 14.700000047683716, 21.174285616193497, 10.94999985396862, 17.62571430206299 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm 14495 6736 164 L99F, F153L Endolysin Enterobacteria phage T4 0.09 yes 51.85 phosphate 20 mM KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 7.0 1L63, 2LZM 14.700000047683716, 18.75727298042991, 10.94999985396862, 15.220908858559348 in pocket 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm 14504 6736 164 L99F, F153L Endolysin Enterobacteria phage T4 0.58 yes 65.47 phosphate 10 mM KCl 0.2 M CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 7.0 1L63, 2LZM 14.700000047683716, 18.75727298042991, 10.94999985396862, 15.220908858559348 in pocket 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm 14921 6736 164 L99F, F153L Endolysin Enterobacteria phage T4 -0.21 yes phosphate 10 mM 64.89 KCl 0.2 M CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 7.0 1L63, 2LZM 14.700000047683716, 18.75727298042991, 10.94999985396862, 15.220908858559348 in pocket 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm 15001 6736 164 L99F, F153L Endolysin Enterobacteria phage T4 -0.03 yes phosphate 20 mM 51.76 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 7.0 1L63, 2LZM 14.700000047683716, 18.75727298042991, 10.94999985396862, 15.220908858559348 in pocket 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm 14498 6739 164 L99F, M102L, V111I Endolysin Enterobacteria phage T4 -4.02 yes 47.24 phosphate 20 mM KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 9.0, 8.0 1L63, 2LZM 14.700000047683716, 17.96749985218048, 21.174285616193497, 10.94999985396862, 13.190000236034393, 17.62571430206299 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm 14507 6739 164 L99F, M102L, V111I Endolysin Enterobacteria phage T4 -3.83 yes 61.06 phosphate 10 mM KCl 0.2 M CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 9.0, 8.0 1L63, 2LZM 14.700000047683716, 17.96749985218048, 21.174285616193497, 10.94999985396862, 13.190000236034393, 17.62571430206299 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm 14924 6739 164 L99F, M102L, V111I Endolysin Enterobacteria phage T4 1.2 yes phosphate 10 mM 64.89 KCl 0.2 M CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 9.0, 8.0 1L63, 2LZM 14.700000047683716, 17.96749985218048, 21.174285616193497, 10.94999985396862, 13.190000236034393, 17.62571430206299 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm 15004 6739 164 L99F, M102L, V111I Endolysin Enterobacteria phage T4 1.15 yes phosphate 20 mM 51.76 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 9.0, 8.0 1L63, 2LZM 14.700000047683716, 17.96749985218048, 21.174285616193497, 10.94999985396862, 13.190000236034393, 17.62571430206299 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm 14499 6740 164 L99F, M102L, F153L Endolysin Enterobacteria phage T4 -0.68 yes 51.08 phosphate 20 mM KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 9.0, 7.0 1L63, 2LZM 14.700000047683716, 17.96749985218048, 18.75727298042991, 10.94999985396862, 13.190000236034393, 15.220908858559348 in pocket 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm 14508 6740 164 L99F, M102L, F153L Endolysin Enterobacteria phage T4 -0.74 yes 64.15 phosphate 10 mM KCl 0.2 M CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 9.0, 7.0 1L63, 2LZM 14.700000047683716, 17.96749985218048, 18.75727298042991, 10.94999985396862, 13.190000236034393, 15.220908858559348 in pocket 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm 14925 6740 164 L99F, M102L, F153L Endolysin Enterobacteria phage T4 0.22 yes phosphate 10 mM 64.89 KCl 0.2 M CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 9.0, 7.0 1L63, 2LZM 14.700000047683716, 17.96749985218048, 18.75727298042991, 10.94999985396862, 13.190000236034393, 15.220908858559348 in pocket 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm 15005 6740 164 L99F, M102L, F153L Endolysin Enterobacteria phage T4 0.21 yes phosphate 20 mM 51.76 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 9.0, 7.0 1L63, 2LZM 14.700000047683716, 17.96749985218048, 18.75727298042991, 10.94999985396862, 13.190000236034393, 15.220908858559348 in pocket 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm 14500 6741 164 L99F, V111I, F153L Endolysin Enterobacteria phage T4 -1.73 yes 50.08 phosphate 20 mM KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 8.0, 7.0 1L63, 2LZM 14.700000047683716, 21.174285616193497, 18.75727298042991, 10.94999985396862, 17.62571430206299, 15.220908858559348 in pocket 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm 14509 6741 164 L99F, V111I, F153L Endolysin Enterobacteria phage T4 -1.25 yes 63.64 phosphate 10 mM KCl 0.2 M CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 8.0, 7.0 1L63, 2LZM 14.700000047683716, 21.174285616193497, 18.75727298042991, 10.94999985396862, 17.62571430206299, 15.220908858559348 in pocket 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm 14926 6741 164 L99F, V111I, F153L Endolysin Enterobacteria phage T4 0.43 yes phosphate 10 mM 64.89 KCl 0.2 M CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 8.0, 7.0 1L63, 2LZM 14.700000047683716, 21.174285616193497, 18.75727298042991, 10.94999985396862, 17.62571430206299, 15.220908858559348 in pocket 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm 15006 6741 164 L99F, V111I, F153L Endolysin Enterobacteria phage T4 0.55 yes phosphate 20 mM 51.76 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 8.0, 7.0 1L63, 2LZM 14.700000047683716, 21.174285616193497, 18.75727298042991, 10.94999985396862, 17.62571430206299, 15.220908858559348 in pocket 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm 14501 6742 164 L99F, M102L, V111I, F153L Endolysin Enterobacteria phage T4 -1.82 yes 49.94 phosphate 20 mM KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 9.0, 8.0, 7.0 1L63, 2LZM 14.700000047683716, 17.96749985218048, 21.174285616193497, 18.75727298042991, 10.94999985396862, 13.190000236034393, 17.62571430206299, 15.220908858559348 in pocket 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm 14510 6742 164 L99F, M102L, V111I, F153L Endolysin Enterobacteria phage T4 -2.07 yes 62.82 phosphate 10 mM KCl 0.2 M CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 9.0, 8.0, 7.0 1L63, 2LZM 14.700000047683716, 17.96749985218048, 21.174285616193497, 18.75727298042991, 10.94999985396862, 13.190000236034393, 17.62571430206299, 15.220908858559348 in pocket 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm 14927 6742 164 L99F, M102L, V111I, F153L Endolysin Enterobacteria phage T4 0.65 yes phosphate 10 mM 64.89 KCl 0.2 M CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 9.0, 8.0, 7.0 1L63, 2LZM 14.700000047683716, 17.96749985218048, 21.174285616193497, 18.75727298042991, 10.94999985396862, 13.190000236034393, 17.62571430206299, 15.220908858559348 in pocket 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm 15007 6742 164 L99F, M102L, V111I, F153L Endolysin Enterobacteria phage T4 0.54 yes phosphate 20 mM 51.76 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 9.0, 8.0, 7.0 1L63, 2LZM 14.700000047683716, 17.96749985218048, 21.174285616193497, 18.75727298042991, 10.94999985396862, 13.190000236034393, 17.62571430206299, 15.220908858559348 in pocket 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm 14767 6920 164 L99A, E108V Endolysin Enterobacteria phage T4 91.0 -10.3 yes(>95%) 41.4 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 5.0 1L63, 2LZM 14.700000047683716, 52.43111101786295, 10.94999985396862, 33.343333350287544 in tunnel in pocket 10512706 10.1006/jmbi.1999.3102 1999 ProTherm 14769 6920 164 L99A, E108V Endolysin Enterobacteria phage T4 114.0 -8.6 yes(>80%) 56.6 Sodium acetate 10 mM NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 5.0 1L63, 2LZM 14.700000047683716, 52.43111101786295, 10.94999985396862, 33.343333350287544 in tunnel in pocket 10512706 10.1006/jmbi.1999.3102 1999 ProTherm 14913 6920 164 L99A, E108V Endolysin Enterobacteria phage T4 3.1 yes(>80%) Sodium acetate 10 mM 65.2 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 5.0 1L63, 2LZM 14.700000047683716, 52.43111101786295, 10.94999985396862, 33.343333350287544 in tunnel in pocket 10512706 10.1006/jmbi.1999.3102 1999 ProTherm 15017 6920 164 L99A, E108V Endolysin Enterobacteria phage T4 3.3 yes(>95%) Potassium phosphate 20 mM 51.7 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 5.0 1L63, 2LZM 14.700000047683716, 52.43111101786295, 10.94999985396862, 33.343333350287544 in tunnel in pocket 10512706 10.1006/jmbi.1999.3102 1999 ProTherm 14768 6921 164 L99G, E108V Endolysin Enterobacteria phage T4 69.0 -21.3 yes(>95%) 30.4 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 5.0 1L63, 2LZM 14.700000047683716, 52.43111101786295, 10.94999985396862, 33.343333350287544 in tunnel in pocket 10512706 10.1006/jmbi.1999.3102 1999 ProTherm 14770 6921 164 L99G, E108V Endolysin Enterobacteria phage T4 93.0 -16.3 yes(>80%) 48.9 Sodium acetate 10 mM NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 5.0 1L63, 2LZM 14.700000047683716, 52.43111101786295, 10.94999985396862, 33.343333350287544 in tunnel in pocket 10512706 10.1006/jmbi.1999.3102 1999 ProTherm 14914 6921 164 L99G, E108V Endolysin Enterobacteria phage T4 5.6 yes(>80%) Sodium acetate 10 mM 65.2 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 5.0 1L63, 2LZM 14.700000047683716, 52.43111101786295, 10.94999985396862, 33.343333350287544 in tunnel in pocket 10512706 10.1006/jmbi.1999.3102 1999 ProTherm 15018 6921 164 L99G, E108V Endolysin Enterobacteria phage T4 6.2 yes(>95%) Potassium phosphate 20 mM 51.7 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 5.0 1L63, 2LZM 14.700000047683716, 52.43111101786295, 10.94999985396862, 33.343333350287544 in tunnel in pocket 10512706 10.1006/jmbi.1999.3102 1999 ProTherm 301 164 164 I100M Endolysin Enterobacteria phage T4 2.5 125.0 -4.5 Unknown 60.8 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 0.1 M CD Thermal 5.42 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 12.707499980926514, 9.35875004529953 8901549 10.1073/pnas.93.22.12155 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 2043 164 164 I100M Endolysin Enterobacteria phage T4 125.0 -4.5 Yes(80%) 2.0 60.8 acetic acid, sodium acetate 1.4 mM, 8.6 mM Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 12.707499980926514, 9.35875004529953 10545167 10.1021/bi9915519 1999 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, EASE-MM_S1676.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv 6772 164 164 I100M Endolysin Enterobacteria phage T4 2.5 1.6 Unknown Acetic acid,Sodium acetate 1.4 mM,8.6 mM 65.3 NaCl 0.1 M CD Thermal 5.42 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 12.707499980926514, 9.35875004529953 8901549 10.1073/pnas.93.22.12155 1996 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 6810 164 164 I100M Endolysin Enterobacteria phage T4 1.6 Yes(80%) 2.0 acetic acid, sodium acetate 1.4 mM, 8.6 mM 65.3 Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 12.707499980926514, 9.35875004529953 10545167 10.1021/bi9915519 1999 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1423 807 164 I100V Endolysin Enterobacteria phage T4 129.0 -1.1 Unknown 64.4 sodium chloride, acetic acid, sodium acetate 0.10 M, 1.4 mM, 8.6 mM CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 12.707499980926514, 9.35875004529953 12963380 10.1016/s0022-2836(03)00856-8 2003 ProTherm 7079 807 164 I100V Endolysin Enterobacteria phage T4 2.5 0.4 Unknown sodium chloride, acetic acid, sodium acetate 0.10 M, 1.4 mM, 8.6 mM 61.0 CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 12.707499980926514, 9.35875004529953 12963380 10.1016/s0022-2836(03)00856-8 2003 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 2028 1133 164 I100A Endolysin Enterobacteria phage T4 118.0 -7.1 Yes(80%) 2.0 58.2 acetic acid, sodium acetate 1.4 mM, 8.6 mM Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 12.707499980926514, 9.35875004529953 10545167 10.1021/bi9915519 1999 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, SVM-WIN31_SVM-3D12_S499.csv 3130 1133 164 I100A Endolysin Enterobacteria phage T4 1.8 85.0 -10.7 Unknown 41.0 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 12.707499980926514, 9.35875004529953 9514271 10.1002/pro.5560070117 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6795 1133 164 I100A Endolysin Enterobacteria phage T4 2.5 Yes(80%) 2.0 acetic acid, sodium acetate 1.4 mM, 8.6 mM 65.3 Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 12.707499980926514, 9.35875004529953 10545167 10.1021/bi9915519 1999 ProTherm khan_protherm_data_mapped.csv 7564 1133 164 I100A Endolysin Enterobacteria phage T4 1.8 3.4 Unknown Potassium phosphate 20 mM 51.65 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 12.707499980926514, 9.35875004529953 9514271 10.1002/pro.5560070117 1998 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 385 204 164 N101A Endolysin Enterobacteria phage T4 113.0 -3.7 Unknown 61.6 sodium acetate 0.010 M NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 16.28250002861023, 11.464999794960022 11316887 10.1110/ps.02101 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7118 204 164 N101A Endolysin Enterobacteria phage T4 1.5 Unknown sodium acetate 0.010 M 59.0 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 16.28250002861023, 11.464999794960022 11316887 10.1110/ps.02101 2001 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 247 134 164 M102V Endolysin Enterobacteria phage T4 2.33 65.3 Unknown 46.85 Unknown CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.96749985218048, 13.190000236034393 7306671 10.1002/bip.1981.360200921 1981 ProTherm 252 134 164 M102V Endolysin Enterobacteria phage T4 2.33 -13.0 Unknown 46.0 Unknown CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.96749985218048, 13.190000236034393 7306671 10.1002/bip.1981.360200921 1981 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 479 134 164 M102V Endolysin Enterobacteria phage T4 -12.7 yes 44.1 Unknown NaCl 0.2 M CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.96749985218048, 13.190000236034393 6726809 10.1016/0022-2836(84)90474-1 1984 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 482 134 164 M102V Endolysin Enterobacteria phage T4 3.0 -12.7 yes 44.1 Unknown NaCl 0.2 M CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.96749985218048, 13.190000236034393 6726809 10.1016/0022-2836(84)90474-1 1984 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 499 284 164 M102L Endolysin Enterobacteria phage T4 -2.54 yes 49.22 phosphate 20 mM KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.96749985218048, 13.190000236034393 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 502 284 164 M102L Endolysin Enterobacteria phage T4 -2.31 yes 62.58 phosphate 10 mM KCl 0.2 M CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.96749985218048, 13.190000236034393 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 1424 284 164 M102L Endolysin Enterobacteria phage T4 118.0 -2.3 Unknown 63.2 sodium chloride, acetic acid, sodium acetate 0.10 M, 1.4 mM, 8.6 mM CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.96749985218048, 13.190000236034393 12963380 10.1016/s0022-2836(03)00856-8 2003 ProTherm 6968 284 164 M102L Endolysin Enterobacteria phage T4 0.82 yes phosphate 10 mM 64.89 KCl 0.2 M CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.96749985218048, 13.190000236034393 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 7080 284 164 M102L Endolysin Enterobacteria phage T4 2.5 1.0 Unknown sodium chloride, acetic acid, sodium acetate 0.10 M, 1.4 mM, 8.6 mM 61.0 CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.96749985218048, 13.190000236034393 12963380 10.1016/s0022-2836(03)00856-8 2003 ProTherm 7506 284 164 M102L Endolysin Enterobacteria phage T4 0.74 yes phosphate 20 mM 51.76 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.96749985218048, 13.190000236034393 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 595 339 164 M102K Endolysin Enterobacteria phage T4 1.8 12.4 -35.0 yes 16.6 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.96749985218048, 13.190000236034393 1747370 10.1021/bi00113a006 1991 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 598 339 164 M102K Endolysin Enterobacteria phage T4 1.8 53.0 -20.3 yes 45.0 Potassium phosphate 20 mM KCl 25 mM CD Thermal 5.3 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.96749985218048, 13.190000236034393 1747370 10.1021/bi00113a006 1991 ProTherm EASE-MM_S238.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 600 339 164 M102K Endolysin Enterobacteria phage T4 1.8 77.4 -10.1 yes(20%) 37.8 Potassium phosphate 20 mM KCl 25 mM CD Thermal 10.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.96749985218048, 13.190000236034393 1747370 10.1021/bi00113a006 1991 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6782 339 164 M102K Endolysin Enterobacteria phage T4 1.8 6.9 yes Potassium phosphate 20 mM 65.3 KCl 25 mM CD Thermal 5.3 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.96749985218048, 13.190000236034393 1747370 10.1021/bi00113a006 1991 ProTherm capriotti_S1615_map.csv 7580 339 164 M102K Endolysin Enterobacteria phage T4 1.8 8.9 yes Potassium phosphate 20 mM 51.6 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.96749985218048, 13.190000236034393 1747370 10.1021/bi00113a006 1991 ProTherm capriotti_S1615_map.csv 7784 339 164 M102K Endolysin Enterobacteria phage T4 1.8 2.2 yes(20%) Potassium phosphate 20 mM 47.9 KCl 25 mM CD Thermal 10.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.96749985218048, 13.190000236034393 1747370 10.1021/bi00113a006 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 622 360 164 M102T Endolysin Enterobacteria phage T4 -13.0 yes 38.6 HCl CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.96749985218048, 13.190000236034393 3323816 10.1016/0076-6879(87)54093-9 1987 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 2027 1132 164 M102A Endolysin Enterobacteria phage T4 108.0 -8.2 Yes(80%) 2.0 57.1 acetic acid, sodium acetate 1.4 mM, 8.6 mM Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.96749985218048, 13.190000236034393 10545167 10.1021/bi9915519 1999 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S499.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 6794 1132 164 M102A Endolysin Enterobacteria phage T4 2.9 Yes(80%) 2.0 acetic acid, sodium acetate 1.4 mM, 8.6 mM 65.3 Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.96749985218048, 13.190000236034393 10545167 10.1021/bi9915519 1999 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14496 6737 164 M102L, V111F Endolysin Enterobacteria phage T4 -5.49 yes 46.27 phosphate 20 mM KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0, 8.0 1L63, 2LZM 17.96749985218048, 21.174285616193497, 13.190000236034393, 17.62571430206299 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm 14505 6737 164 M102L, V111F Endolysin Enterobacteria phage T4 -6.19 yes 58.7 phosphate 10 mM KCl 0.2 M CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0, 8.0 1L63, 2LZM 17.96749985218048, 21.174285616193497, 13.190000236034393, 17.62571430206299 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm 14922 6737 164 M102L, V111F Endolysin Enterobacteria phage T4 2.11 yes phosphate 10 mM 64.89 KCl 0.2 M CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0, 8.0 1L63, 2LZM 17.96749985218048, 21.174285616193497, 13.190000236034393, 17.62571430206299 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm 15002 6737 164 M102L, V111F Endolysin Enterobacteria phage T4 1.51 yes phosphate 20 mM 51.76 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0, 8.0 1L63, 2LZM 17.96749985218048, 21.174285616193497, 13.190000236034393, 17.62571430206299 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm 14650 6827 164 M102A, M106A Endolysin Enterobacteria phage T4 101.0 -10.8 Yes(80%) 2.0 54.5 acetic acid, sodium acetate 1.4 mM, 8.6 mM Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0, 8.0 1L63, 2LZM 17.96749985218048, 31.316250324249268, 13.190000236034393, 25.181249856948853 in tunnel in pocket 10545167 10.1021/bi9915519 1999 ProTherm 14911 6827 164 M102A, M106A Endolysin Enterobacteria phage T4 3.7 Yes(80%) 2.0 acetic acid, sodium acetate 1.4 mM, 8.6 mM 65.3 Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0, 8.0 1L63, 2LZM 17.96749985218048, 31.316250324249268, 13.190000236034393, 25.181249856948853 in tunnel in pocket 10545167 10.1021/bi9915519 1999 ProTherm 302 165 164 V103M Endolysin Enterobacteria phage T4 2.5 117.0 -3.1 Unknown 62.2 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 0.1 M CD Thermal 5.42 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 17.41999966757638, 14.118571281433105 in tunnel in pocket 8901549 10.1073/pnas.93.22.12155 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6773 165 164 V103M Endolysin Enterobacteria phage T4 2.5 1.2 Unknown Acetic acid,Sodium acetate 1.4 mM,8.6 mM 65.3 NaCl 0.1 M CD Thermal 5.42 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 17.41999966757638, 14.118571281433105 in tunnel in pocket 8901549 10.1073/pnas.93.22.12155 1996 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1425 808 164 V103I Endolysin Enterobacteria phage T4 130.0 -1.5 Unknown 64.0 sodium chloride, acetic acid, sodium acetate 0.10 M, 1.4 mM, 8.6 mM CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 17.41999966757638, 14.118571281433105 in tunnel in pocket 12963380 10.1016/s0022-2836(03)00856-8 2003 ProTherm 7081 808 164 V103I Endolysin Enterobacteria phage T4 2.5 0.5 Unknown sodium chloride, acetic acid, sodium acetate 0.10 M, 1.4 mM, 8.6 mM 61.0 CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 17.41999966757638, 14.118571281433105 in tunnel in pocket 12963380 10.1016/s0022-2836(03)00856-8 2003 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 2029 1134 164 V103A Endolysin Enterobacteria phage T4 122.0 -4.4 Yes(80%) 2.0 60.9 acetic acid, sodium acetate 1.4 mM, 8.6 mM Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 17.41999966757638, 14.118571281433105 in tunnel in pocket 10545167 10.1021/bi9915519 1999 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, M47andM8_S1810.csv 3134 1134 164 V103A Endolysin Enterobacteria phage T4 1.8 94.0 -6.6 Unknown 45.1 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 17.41999966757638, 14.118571281433105 in tunnel in pocket 9514271 10.1002/pro.5560070117 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6796 1134 164 V103A Endolysin Enterobacteria phage T4 1.6 Yes(80%) 2.0 acetic acid, sodium acetate 1.4 mM, 8.6 mM 65.3 Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 17.41999966757638, 14.118571281433105 in tunnel in pocket 10545167 10.1021/bi9915519 1999 ProTherm khan_protherm_data_mapped.csv 7568 1134 164 V103A Endolysin Enterobacteria phage T4 1.8 2.2 Unknown Potassium phosphate 20 mM 51.65 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 17.41999966757638, 14.118571281433105 in tunnel in pocket 9514271 10.1002/pro.5560070117 1998 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 12615 1134 164 V103A Endolysin Enterobacteria phage T4 5.3 1.91 Unknown imidazole,MOPS, 0.05 M,0.05 M, 22.0 Gel electrophoresis Urea 7.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 17.41999966757638, 14.118571281433105 in tunnel in pocket 1988046 10.1021/bi00216a038 1991 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 2030 1135 164 F104A Endolysin Enterobacteria phage T4 109.0 -7.5 Yes(80%) 2.0 57.8 acetic acid, sodium acetate 1.4 mM, 8.6 mM Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 9.0 1L63, 2LZM 14.909090995788574, 11.377272822640158 in tunnel in pocket 10545167 10.1021/bi9915519 1999 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, PON-TStab_dataset.csv 3140 1135 164 F104A Endolysin Enterobacteria phage T4 1.8 82.0 -9.7 Unknown 42.0 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 9.0 1L63, 2LZM 14.909090995788574, 11.377272822640158 in tunnel in pocket 9514271 10.1002/pro.5560070117 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6797 1135 164 F104A Endolysin Enterobacteria phage T4 2.7 Yes(80%) 2.0 acetic acid, sodium acetate 1.4 mM, 8.6 mM 65.3 Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 9.0 1L63, 2LZM 14.909090995788574, 11.377272822640158 in tunnel in pocket 10545167 10.1021/bi9915519 1999 ProTherm khan_protherm_data_mapped.csv 7574 1135 164 F104A Endolysin Enterobacteria phage T4 1.8 3.1 Unknown Potassium phosphate 20 mM 51.65 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 9.0 1L63, 2LZM 14.909090995788574, 11.377272822640158 in tunnel in pocket 9514271 10.1002/pro.5560070117 1998 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 2044 1143 164 F104M Endolysin Enterobacteria phage T4 121.0 -0.8 Yes(80%) 2.0 64.5 acetic acid, sodium acetate 1.4 mM, 8.6 mM Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 9.0 1L63, 2LZM 14.909090995788574, 11.377272822640158 in tunnel in pocket 10545167 10.1021/bi9915519 1999 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, M47andM8_S1810.csv 6811 1143 164 F104M Endolysin Enterobacteria phage T4 0.4 Yes(80%) 2.0 acetic acid, sodium acetate 1.4 mM, 8.6 mM 65.3 Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 9.0 1L63, 2LZM 14.909090995788574, 11.377272822640158 in tunnel in pocket 10545167 10.1021/bi9915519 1999 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 378 200 164 Q105A Endolysin Enterobacteria phage T4 77.0 -3.5 yes 38.5 H3PO4 17 mM KCl 0.15 M CD Thermal 2.1 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 18.447777642144096, 19.492221938239204 in tunnel in pocket 8460110 10.1002/prot.340150407 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 381 200 164 Q105A Endolysin Enterobacteria phage T4 127.0 -1.6 yes 64.7 KH2PO4 10 mM KCl 0.15 M CD Thermal 5.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 18.447777642144096, 19.492221938239204 in tunnel in pocket 8460110 10.1002/prot.340150407 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6743 200 164 Q105A Endolysin Enterobacteria phage T4 0.6 yes KH2PO4 10 mM 66.3 KCl 0.15 M CD Thermal 5.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 18.447777642144096, 19.492221938239204 in tunnel in pocket 8460110 10.1002/prot.340150407 1993 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8013 200 164 Q105A Endolysin Enterobacteria phage T4 0.9 yes H3PO4 17 mM 42.0 KCl 0.15 M CD Thermal 2.1 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 18.447777642144096, 19.492221938239204 in tunnel in pocket 8460110 10.1002/prot.340150407 1993 ProTherm capriotti_S1615_map.csv 379 201 164 Q105E Endolysin Enterobacteria phage T4 82.0 -2.1 yes 39.9 H3PO4 17 mM KCl 0.15 M CD Thermal 2.1 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 18.447777642144096, 19.492221938239204 in tunnel in pocket 8460110 10.1002/prot.340150407 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 382 201 164 Q105E Endolysin Enterobacteria phage T4 124.0 -3.0 yes 63.3 KH2PO4 10 mM KCl 0.15 M CD Thermal 5.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 18.447777642144096, 19.492221938239204 in tunnel in pocket 8460110 10.1002/prot.340150407 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6744 201 164 Q105E Endolysin Enterobacteria phage T4 1.1 yes KH2PO4 10 mM 66.3 KCl 0.15 M CD Thermal 5.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 18.447777642144096, 19.492221938239204 in tunnel in pocket 8460110 10.1002/prot.340150407 1993 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, potapov_with_uniprot_mapping.csv 8014 201 164 Q105E Endolysin Enterobacteria phage T4 0.5 yes H3PO4 17 mM 42.0 KCl 0.15 M CD Thermal 2.1 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 18.447777642144096, 19.492221938239204 in tunnel in pocket 8460110 10.1002/prot.340150407 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 380 202 164 Q105G Endolysin Enterobacteria phage T4 72.0 -7.2 yes 34.8 H3PO4 17 mM KCl 0.15 M CD Thermal 2.1 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 18.447777642144096, 19.492221938239204 in tunnel in pocket 8460110 10.1002/prot.340150407 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 383 202 164 Q105G Endolysin Enterobacteria phage T4 132.0 -3.9 yes 62.4 KH2PO4 10 mM KCl 0.15 M CD Thermal 5.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 18.447777642144096, 19.492221938239204 in tunnel in pocket 8460110 10.1002/prot.340150407 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6745 202 164 Q105G Endolysin Enterobacteria phage T4 1.5 yes KH2PO4 10 mM 66.3 KCl 0.15 M CD Thermal 5.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 18.447777642144096, 19.492221938239204 in tunnel in pocket 8460110 10.1002/prot.340150407 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 8015 202 164 Q105G Endolysin Enterobacteria phage T4 1.7 yes H3PO4 17 mM 42.0 KCl 0.15 M CD Thermal 2.1 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 18.447777642144096, 19.492221938239204 in tunnel in pocket 8460110 10.1002/prot.340150407 1993 ProTherm capriotti_S1615_map.csv 12616 202 164 Q105G Endolysin Enterobacteria phage T4 4.7 3.11 Unknown imidazole,MOPS, 0.05 M,0.05 M, 22.0 Gel electrophoresis Urea 7.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 18.447777642144096, 19.492221938239204 in tunnel in pocket 1988046 10.1021/bi00216a038 1991 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 386 205 164 Q105M Endolysin Enterobacteria phage T4 110.0 -2.7 Unknown 62.6 sodium acetate 0.010 M NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 18.447777642144096, 19.492221938239204 in tunnel in pocket 11316887 10.1110/ps.02101 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7119 205 164 Q105M Endolysin Enterobacteria phage T4 1.2 Unknown sodium acetate 0.010 M 59.0 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 18.447777642144096, 19.492221938239204 in tunnel in pocket 11316887 10.1110/ps.02101 2001 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1426 809 164 M106I Endolysin Enterobacteria phage T4 132.0 0.6 Unknown 66.1 sodium chloride, acetic acid, sodium acetate 0.10 M, 1.4 mM, 8.6 mM CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 31.316250324249268, 25.181249856948853 in tunnel in pocket 12963380 10.1016/s0022-2836(03)00856-8 2003 ProTherm 7082 809 164 M106I Endolysin Enterobacteria phage T4 2.5 -0.2 Unknown sodium chloride, acetic acid, sodium acetate 0.10 M, 1.4 mM, 8.6 mM 61.0 CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 31.316250324249268, 25.181249856948853 in tunnel in pocket 12963380 10.1016/s0022-2836(03)00856-8 2003 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 2031 1136 164 M106A Endolysin Enterobacteria phage T4 114.0 -5.2 Yes(80%) 2.0 60.1 acetic acid, sodium acetate 1.4 mM, 8.6 mM Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 31.316250324249268, 25.181249856948853 in tunnel in pocket 10545167 10.1021/bi9915519 1999 ProTherm EASE-MM_S1676.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv 3138 1136 164 M106A Endolysin Enterobacteria phage T4 1.8 89.0 -7.1 Unknown 44.6 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 31.316250324249268, 25.181249856948853 in tunnel in pocket 9514271 10.1002/pro.5560070117 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6798 1136 164 M106A Endolysin Enterobacteria phage T4 1.9 Yes(80%) 2.0 acetic acid, sodium acetate 1.4 mM, 8.6 mM 65.3 Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 31.316250324249268, 25.181249856948853 in tunnel in pocket 10545167 10.1021/bi9915519 1999 ProTherm khan_protherm_data_mapped.csv 7572 1136 164 M106A Endolysin Enterobacteria phage T4 1.8 2.3 Unknown Potassium phosphate 20 mM 51.65 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 31.316250324249268, 25.181249856948853 in tunnel in pocket 9514271 10.1002/pro.5560070117 1998 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3147 1681 164 M106L Endolysin Enterobacteria phage T4 111.0 1.7 yes (>95%) 53.4 phosphoric acid,Potassium phosphate, 3 mM,17 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 31.316250324249268, 25.181249856948853 in tunnel in pocket 9541409 10.1002/pro.5560070326 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7812 1681 164 M106L Endolysin Enterobacteria phage T4 1.8 -0.5 yes (>95%) phosphoric acid, Potassium phosphate 3 mM, 17 mM 47.0 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 31.316250324249268, 25.181249856948853 in tunnel in pocket 9541409 10.1002/pro.5560070326 1998 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3149 1683 164 M106K Endolysin Enterobacteria phage T4 90.0 -10.5 yes (>95%) 41.2 phosphoric acid,Potassium phosphate, 3 mM,17 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 31.316250324249268, 25.181249856948853 in tunnel in pocket 9541409 10.1002/pro.5560070326 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7814 1683 164 M106K Endolysin Enterobacteria phage T4 1.8 3.4 yes (>95%) phosphoric acid, Potassium phosphate 3 mM, 17 mM 47.0 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 31.316250324249268, 25.181249856948853 in tunnel in pocket 9541409 10.1002/pro.5560070326 1998 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1498 869 164 E108V Endolysin Enterobacteria phage T4 2.5 134.0 3.6 Unknown 55.2 glycine-HCl 20 mM CD Thermal 3.02 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 52.43111101786295, 33.343333350287544 in tunnel in pocket 15340171 10.1110/ps.04875504 2004 ProTherm 3823 869 164 E108V Endolysin Enterobacteria phage T4 113.0 4.3 yes(>95%) 56.0 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 52.43111101786295, 33.343333350287544 in tunnel in pocket 10512706 10.1006/jmbi.1999.3102 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q306.csv, STRUM_Q3421.csv, AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3826 869 164 E108V Endolysin Enterobacteria phage T4 128.0 2.4 yes(>80%) 67.6 Sodium acetate 10 mM NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 52.43111101786295, 33.343333350287544 in tunnel in pocket 10512706 10.1006/jmbi.1999.3102 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6815 869 164 E108V Endolysin Enterobacteria phage T4 -0.7 yes(>80%) Sodium acetate 10 mM 65.2 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 52.43111101786295, 33.343333350287544 in tunnel in pocket 10512706 10.1006/jmbi.1999.3102 1999 ProTherm khan_protherm_data_mapped.csv 7520 869 164 E108V Endolysin Enterobacteria phage T4 -1.2 yes(>95%) Potassium phosphate 20 mM 51.7 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 52.43111101786295, 33.343333350287544 in tunnel in pocket 10512706 10.1006/jmbi.1999.3102 1999 ProTherm potapov_with_uniprot_mapping.csv 7582 869 164 E108V Endolysin Enterobacteria phage T4 2.5 -1.4 Unknown glycine-HCl 20 mM 51.6 CD Thermal 3.02 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 52.43111101786295, 33.343333350287544 in tunnel in pocket 15340171 10.1110/ps.04875504 2004 ProTherm 820 505 164 T109D Endolysin Enterobacteria phage T4 -0.8 yes 38.7 HCl 0.01 N KCl 200 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 32.278571537562776, 32.89142853873117 in tunnel 1911773 10.1021/bi00105a002 1991 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 825 505 164 T109D Endolysin Enterobacteria phage T4 1.5 yes 63.9 HCl 0.01 N KCl 200 mM CD Thermal 6.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 32.278571537562776, 32.89142853873117 in tunnel 1911773 10.1021/bi00105a002 1991 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7064 505 164 T109D Endolysin Enterobacteria phage T4 -0.6 yes HCl 0.01 N 62.4 KCl 200 mM CD Thermal 6.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 32.278571537562776, 32.89142853873117 in tunnel 1911773 10.1021/bi00105a002 1991 ProTherm capriotti_S1615_map.csv 8159 505 164 T109D Endolysin Enterobacteria phage T4 0.3 yes HCl 0.01 N 39.5 KCl 200 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 32.278571537562776, 32.89142853873117 in tunnel 1911773 10.1021/bi00105a002 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 821 506 164 T109N Endolysin Enterobacteria phage T4 -0.1 yes 39.4 HCl 0.01 N KCl 200 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 32.278571537562776, 32.89142853873117 in tunnel 1911773 10.1021/bi00105a002 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 826 506 164 T109N Endolysin Enterobacteria phage T4 0.3 yes 62.7 HCl 0.01 N KCl 200 mM CD Thermal 6.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 32.278571537562776, 32.89142853873117 in tunnel 1911773 10.1021/bi00105a002 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7065 506 164 T109N Endolysin Enterobacteria phage T4 -0.1 yes HCl 0.01 N 62.4 KCl 200 mM CD Thermal 6.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 32.278571537562776, 32.89142853873117 in tunnel 1911773 10.1021/bi00105a002 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8160 506 164 T109N Endolysin Enterobacteria phage T4 0.0 yes HCl 0.01 N 39.5 KCl 200 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 32.278571537562776, 32.89142853873117 in tunnel 1911773 10.1021/bi00105a002 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 500 285 164 V111F Endolysin Enterobacteria phage T4 -4.77 yes 46.99 phosphate 20 mM KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 21.174285616193497, 17.62571430206299 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 503 285 164 V111F Endolysin Enterobacteria phage T4 -4.63 yes 60.26 phosphate 10 mM KCl 0.2 M CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 21.174285616193497, 17.62571430206299 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6969 285 164 V111F Endolysin Enterobacteria phage T4 1.69 yes phosphate 10 mM 64.89 KCl 0.2 M CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 21.174285616193497, 17.62571430206299 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm capriotti_S1615_map.csv 7507 285 164 V111F Endolysin Enterobacteria phage T4 1.43 yes phosphate 20 mM 51.76 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 21.174285616193497, 17.62571430206299 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 501 286 164 V111I Endolysin Enterobacteria phage T4 -2.32 yes 49.44 phosphate 20 mM KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 21.174285616193497, 17.62571430206299 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 504 286 164 V111I Endolysin Enterobacteria phage T4 -2.6 yes 62.29 phosphate 10 mM KCl 0.2 M CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 21.174285616193497, 17.62571430206299 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6970 286 164 V111I Endolysin Enterobacteria phage T4 0.85 yes phosphate 10 mM 64.89 KCl 0.2 M CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 21.174285616193497, 17.62571430206299 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 7508 286 164 V111I Endolysin Enterobacteria phage T4 0.69 yes phosphate 20 mM 51.76 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 21.174285616193497, 17.62571430206299 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1427 810 164 V111A Endolysin Enterobacteria phage T4 121.0 -2.9 Unknown 62.6 sodium chloride, acetic acid, sodium acetate 0.10 M, 1.4 mM, 8.6 mM CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 21.174285616193497, 17.62571430206299 12963380 10.1016/s0022-2836(03)00856-8 2003 ProTherm 2032 810 164 V111A Endolysin Enterobacteria phage T4 127.0 -2.9 Yes(80%) 2.0 62.4 acetic acid, sodium acetate 1.4 mM, 8.6 mM Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 21.174285616193497, 17.62571430206299 10545167 10.1021/bi9915519 1999 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 3135 810 164 V111A Endolysin Enterobacteria phage T4 1.8 100.0 -3.7 Unknown 48.0 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 21.174285616193497, 17.62571430206299 9514271 10.1002/pro.5560070117 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6799 810 164 V111A Endolysin Enterobacteria phage T4 1.0 Yes(80%) 2.0 acetic acid, sodium acetate 1.4 mM, 8.6 mM 65.3 Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 21.174285616193497, 17.62571430206299 10545167 10.1021/bi9915519 1999 ProTherm khan_protherm_data_mapped.csv 7083 810 164 V111A Endolysin Enterobacteria phage T4 2.5 1.1 Unknown sodium chloride, acetic acid, sodium acetate 0.10 M, 1.4 mM, 8.6 mM 61.0 CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 21.174285616193497, 17.62571430206299 12963380 10.1016/s0022-2836(03)00856-8 2003 ProTherm khan_protherm_data_mapped.csv 7569 810 164 V111A Endolysin Enterobacteria phage T4 1.8 1.3 Unknown Potassium phosphate 20 mM 51.65 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 21.174285616193497, 17.62571430206299 9514271 10.1002/pro.5560070117 1998 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, potapov_with_uniprot_mapping.csv 2045 1144 164 V111M Endolysin Enterobacteria phage T4 127.0 -2.0 Yes(80%) 2.0 63.3 acetic acid, sodium acetate 1.4 mM, 8.6 mM Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 21.174285616193497, 17.62571430206299 10545167 10.1021/bi9915519 1999 ProTherm EASE-MM_S1676.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv 6812 1144 164 V111M Endolysin Enterobacteria phage T4 0.7 Yes(80%) 2.0 acetic acid, sodium acetate 1.4 mM, 8.6 mM 65.3 Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 21.174285616193497, 17.62571430206299 10545167 10.1021/bi9915519 1999 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14497 6738 164 V111I, F153L Endolysin Enterobacteria phage T4 -3.52 yes 48.24 phosphate 20 mM KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 7.0 1L63, 2LZM 21.174285616193497, 18.75727298042991, 17.62571430206299, 15.220908858559348 in pocket 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm 14506 6738 164 V111I, F153L Endolysin Enterobacteria phage T4 -3.24 yes 61.65 phosphate 10 mM KCl 0.2 M CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 7.0 1L63, 2LZM 21.174285616193497, 18.75727298042991, 17.62571430206299, 15.220908858559348 in pocket 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm 14923 6738 164 V111I, F153L Endolysin Enterobacteria phage T4 1.09 yes phosphate 10 mM 64.89 KCl 0.2 M CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 7.0 1L63, 2LZM 21.174285616193497, 18.75727298042991, 17.62571430206299, 15.220908858559348 in pocket 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm 15003 6738 164 V111I, F153L Endolysin Enterobacteria phage T4 1.09 yes phosphate 20 mM 51.76 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0, 7.0 1L63, 2LZM 21.174285616193497, 18.75727298042991, 17.62571430206299, 15.220908858559348 in pocket 1569571 10.1016/0022-2836(92)90475-y 1992 ProTherm 196 102 164 G113E Endolysin Enterobacteria phage T4 3.5 126.0 0.79 Unknown 65.94 Sodium acetate 10 mM NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 30.420000553131104, 35.14999961853027 in pocket 7507755 10.1002/pro.5560021221 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 208 102 164 G113E Endolysin Enterobacteria phage T4 3.5 1.03 Unknown 63.22 Potassium phosphate 0.01 M KCl 0.15 M CD Thermal 6.78 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 30.420000553131104, 35.14999961853027 in pocket 7507755 10.1002/pro.5560021221 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6825 102 164 G113E Endolysin Enterobacteria phage T4 3.5 -0.3 Unknown Sodium acetate 10 mM 65.15 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 30.420000553131104, 35.14999961853027 in pocket 7507755 10.1002/pro.5560021221 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 789 481 164 G113A Endolysin Enterobacteria phage T4 99.0 0.4 yes 42.3 H3PO4,HCl, 10 mM,10 mM, KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 30.420000553131104, 35.14999961853027 in pocket 1457724 10.1002/bip.360321103 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 794 481 164 G113A Endolysin Enterobacteria phage T4 120.0 0.8 yes 65.3 Potassium phosphate 10 mM KCl 0.15 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 30.420000553131104, 35.14999961853027 in pocket 1457724 10.1002/bip.360321103 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 892 481 164 G113A Endolysin Enterobacteria phage T4 yes 38.8 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 30.420000553131104, 35.14999961853027 in pocket 1737020 10.1021/bi00121a009 1992 ProTherm 895 481 164 G113A Endolysin Enterobacteria phage T4 yes 46.2 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 30.420000553131104, 35.14999961853027 in pocket 1737020 10.1021/bi00121a009 1992 ProTherm 898 481 164 G113A Endolysin Enterobacteria phage T4 yes 53.6 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 30.420000553131104, 35.14999961853027 in pocket 1737020 10.1021/bi00121a009 1992 ProTherm 7003 481 164 G113A Endolysin Enterobacteria phage T4 -0.3 yes Potassium phosphate 10 mM 64.7 KCl 0.15 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 30.420000553131104, 35.14999961853027 in pocket 1457724 10.1002/bip.360321103 1992 ProTherm capriotti_S1615_map.csv 7330 481 164 G113A Endolysin Enterobacteria phage T4 2.52 -0.54 yes Potassium phosphate 20 mM 53.6 KCl 25 mM DSC Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 30.420000553131104, 35.14999961853027 in pocket 1737020 10.1021/bi00121a009 1992 ProTherm capriotti_S1615_map.csv 7848 481 164 G113A Endolysin Enterobacteria phage T4 2.52 -0.54 yes Potassium phosphate 20 mM 46.2 KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 30.420000553131104, 35.14999961853027 in pocket 1737020 10.1021/bi00121a009 1992 ProTherm capriotti_S1615_map.csv 8050 481 164 G113A Endolysin Enterobacteria phage T4 -0.1 yes H3PO4,HCl 10 mM,10 mM 41.9 KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 30.420000553131104, 35.14999961853027 in pocket 1457724 10.1002/bip.360321103 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 8212 481 164 G113A Endolysin Enterobacteria phage T4 2.52 -0.5 yes Potassium phosphate 20 mM 38.8 KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 30.420000553131104, 35.14999961853027 in pocket 1737020 10.1021/bi00121a009 1992 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 319 180 164 T115A Endolysin Enterobacteria phage T4 109.0 -0.43 yes 51.22 H3PO4,KH2PO4, 0.0029 M,0.017 M, KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 26.937142644609725, 22.11428533281599 in pocket 7869383 10.1006/jmbi.1994.0087 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7549 180 164 T115A Endolysin Enterobacteria phage T4 0.14 yes H3PO4,KH2PO4 0.0029 M, 0.017 M 51.65 KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 26.937142644609725, 22.11428533281599 in pocket 7869383 10.1006/jmbi.1994.0087 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3295 1738 164 T115E Endolysin Enterobacteria phage T4 -1.7 yes 39.2 HCl 0.01 N KCl 200 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 26.937142644609725, 22.11428533281599 in pocket 1911773 10.1021/bi00105a002 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3300 1738 164 T115E Endolysin Enterobacteria phage T4 0.7 yes 66.8 phosphate 10 mM KCl 150 mM CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 26.937142644609725, 22.11428533281599 in pocket 1911773 10.1021/bi00105a002 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3402 1738 164 T115E Endolysin Enterobacteria phage T4 84.0 -1.7 yes 38.7 HCl 10 mM KCl 0.15 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 26.937142644609725, 22.11428533281599 in pocket 1854726 10.1021/bi00243a015 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3403 1738 164 T115E Endolysin Enterobacteria phage T4 117.0 -0.6 yes 52.0 Potassium phosphate 10 mM KCl 0.15 M CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 26.937142644609725, 22.11428533281599 in pocket 1854726 10.1021/bi00243a015 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, AUTOMUTE_S1749.csv, EASE-MM_S543.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S1791.csv, STRUM_Q3421.csv 3404 1738 164 T115E Endolysin Enterobacteria phage T4 131.0 -0.3 yes 63.3 acetate 10 mM KCl 0.15 M CD Thermal 4.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 26.937142644609725, 22.11428533281599 in pocket 1854726 10.1021/bi00243a015 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3405 1738 164 T115E Endolysin Enterobacteria phage T4 126.0 0.1 yes 66.8 acetate 10 mM KCl 0.15 M CD Thermal 5.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 26.937142644609725, 22.11428533281599 in pocket 1854726 10.1021/bi00243a015 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3406 1738 164 T115E Endolysin Enterobacteria phage T4 125.0 0.7 yes 65.3 Potassium phosphate 10 mM KCl 0.15 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 26.937142644609725, 22.11428533281599 in pocket 1854726 10.1021/bi00243a015 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, SVM-WIN31_SVM-3D12_S499.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6715 1738 164 T115E Endolysin Enterobacteria phage T4 0.0 yes acetate 10 mM 66.7 KCl 0.15 M CD Thermal 5.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 26.937142644609725, 22.11428533281599 in pocket 1854726 10.1021/bi00243a015 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 6750 1738 164 T115E Endolysin Enterobacteria phage T4 -0.3 yes phosphate 10 mM 66.1 KCl 150 mM CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 26.937142644609725, 22.11428533281599 in pocket 1911773 10.1021/bi00105a002 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 7006 1738 164 T115E Endolysin Enterobacteria phage T4 -0.3 yes Potassium phosphate 10 mM 64.6 KCl 0.15 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 26.937142644609725, 22.11428533281599 in pocket 1854726 10.1021/bi00243a015 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 7034 1738 164 T115E Endolysin Enterobacteria phage T4 0.1 yes acetate 10 mM 63.6 KCl 0.15 M CD Thermal 4.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 26.937142644609725, 22.11428533281599 in pocket 1854726 10.1021/bi00243a015 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 7430 1738 164 T115E Endolysin Enterobacteria phage T4 0.2 yes Potassium phosphate 10 mM 52.6 KCl 0.15 M CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 26.937142644609725, 22.11428533281599 in pocket 1854726 10.1021/bi00243a015 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 8064 1738 164 T115E Endolysin Enterobacteria phage T4 0.5 yes HCl 0.01 N 40.9 KCl 200 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 26.937142644609725, 22.11428533281599 in pocket 1911773 10.1021/bi00105a002 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 8078 1738 164 T115E Endolysin Enterobacteria phage T4 0.5 yes HCl 10 mM 40.4 KCl 0.15 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 26.937142644609725, 22.11428533281599 in pocket 1854726 10.1021/bi00243a015 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 14480 6721 164 T115A, S117A Endolysin Enterobacteria phage T4 109.0 2.84 yes 54.49 H3PO4,KH2PO4, 0.0029 M,0.017 M, KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 5.0, 8.0 1L63, 2LZM 26.937142644609725, 19.37499984105428, 22.11428533281599, 17.96833340326945 in pocket 7869383 10.1006/jmbi.1994.0087 1995 ProTherm 15020 6721 164 T115A, S117A Endolysin Enterobacteria phage T4 -0.95 yes H3PO4,KH2PO4 0.0029 M, 0.017 M 51.65 KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 5.0, 8.0 1L63, 2LZM 26.937142644609725, 19.37499984105428, 22.11428533281599, 17.96833340326945 in pocket 7869383 10.1006/jmbi.1994.0087 1995 ProTherm 14483 6724 164 T115A, R119A Endolysin Enterobacteria phage T4 106.0 -0.52 yes 51.13 H3PO4,KH2PO4, 0.0029 M,0.017 M, KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0, 4.0 1L63, 2LZM 26.937142644609725, 54.452727404507726, 22.11428533281599, 37.932726946744054 in pocket 7869383 10.1006/jmbi.1994.0087 1995 ProTherm 15023 6724 164 T115A, R119A Endolysin Enterobacteria phage T4 0.17 yes H3PO4,KH2PO4 0.0029 M, 0.017 M 51.65 KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0, 4.0 1L63, 2LZM 26.937142644609725, 54.452727404507726, 22.11428533281599, 37.932726946744054 in pocket 7869383 10.1006/jmbi.1994.0087 1995 ProTherm 320 181 164 N116A Endolysin Enterobacteria phage T4 109.0 0.49 yes 52.14 H3PO4,KH2PO4, 0.0029 M,0.017 M, KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 24.97124981880188, 24.317500114440918 in pocket 7869383 10.1006/jmbi.1994.0087 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7550 181 164 N116A Endolysin Enterobacteria phage T4 -0.17 yes H3PO4,KH2PO4 0.0029 M, 0.017 M 51.65 KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 24.97124981880188, 24.317500114440918 in pocket 7869383 10.1006/jmbi.1994.0087 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 905 530 164 N116D Endolysin Enterobacteria phage T4 1.8 131.0 0.9 Unknown 54.32 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 24.97124981880188, 24.317500114440918 in pocket 8771182 10.1093/protein/8.10.1017 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 912 530 164 N116D Endolysin Enterobacteria phage T4 2.5 139.0 1.36 Unknown 67.87 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 24.97124981880188, 24.317500114440918 in pocket 8771182 10.1093/protein/8.10.1017 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3296 530 164 N116D Endolysin Enterobacteria phage T4 -0.2 yes 40.7 HCl 0.01 N KCl 200 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 24.97124981880188, 24.317500114440918 in pocket 1911773 10.1021/bi00105a002 1991 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3301 530 164 N116D Endolysin Enterobacteria phage T4 1.6 yes 67.7 phosphate 10 mM KCl 150 mM CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 24.97124981880188, 24.317500114440918 in pocket 1911773 10.1021/bi00105a002 1991 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6727 530 164 N116D Endolysin Enterobacteria phage T4 2.5 -0.6 Unknown Acetic acid, Sodium acetate 1.4 mM, 8.6 mM 66.51 NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 24.97124981880188, 24.317500114440918 in pocket 8771182 10.1093/protein/8.10.1017 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, potapov_with_uniprot_mapping.csv 6751 530 164 N116D Endolysin Enterobacteria phage T4 -0.6 yes phosphate 10 mM 66.1 KCl 150 mM CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 24.97124981880188, 24.317500114440918 in pocket 1911773 10.1021/bi00105a002 1991 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, potapov_with_uniprot_mapping.csv 7342 530 164 N116D Endolysin Enterobacteria phage T4 1.8 -0.34 Unknown KH2PO4, H3PO4 17 mM, 3 mM 53.42 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 24.97124981880188, 24.317500114440918 in pocket 8771182 10.1093/protein/8.10.1017 1995 ProTherm capriotti_S1615_map.csv 8065 530 164 N116D Endolysin Enterobacteria phage T4 0.1 yes HCl 0.01 N 40.9 KCl 200 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 24.97124981880188, 24.317500114440918 in pocket 1911773 10.1021/bi00105a002 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 14484 6725 164 N116A, M120A Endolysin Enterobacteria phage T4 116.0 0.58 yes 52.23 H3PO4,KH2PO4, 0.0029 M,0.017 M, KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 5.0 1L63, 2LZM 24.97124981880188, 22.607500076293945, 24.317500114440918, 22.941250324249268 in pocket 7869383 10.1006/jmbi.1994.0087 1995 ProTherm 15024 6725 164 N116A, M120A Endolysin Enterobacteria phage T4 -0.21 yes H3PO4,KH2PO4 0.0029 M, 0.017 M 51.65 KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 5.0 1L63, 2LZM 24.97124981880188, 22.607500076293945, 24.317500114440918, 22.941250324249268 in pocket 7869383 10.1006/jmbi.1994.0087 1995 ProTherm 14537 6765 164 N116D, R119M Endolysin Enterobacteria phage T4 -0.8 yes 40.1 HCl 0.01 N KCl 200 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 4.0 1L63, 2LZM 24.97124981880188, 54.452727404507726, 24.317500114440918, 37.932726946744054 in pocket 1911773 10.1021/bi00105a002 1991 ProTherm 14538 6765 164 N116D, R119M Endolysin Enterobacteria phage T4 1.6 yes 67.7 HCl 0.01 N KCl 200 mM CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 4.0 1L63, 2LZM 24.97124981880188, 54.452727404507726, 24.317500114440918, 37.932726946744054 in pocket 1911773 10.1021/bi00105a002 1991 ProTherm 14904 6765 164 N116D, R119M Endolysin Enterobacteria phage T4 -0.6 yes HCl 0.01 N 66.1 KCl 200 mM CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 4.0 1L63, 2LZM 24.97124981880188, 54.452727404507726, 24.317500114440918, 37.932726946744054 in pocket 1911773 10.1021/bi00105a002 1991 ProTherm 15098 6765 164 N116D, R119M Endolysin Enterobacteria phage T4 0.3 yes HCl 0.01 N 40.9 KCl 200 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 4.0 1L63, 2LZM 24.97124981880188, 54.452727404507726, 24.317500114440918, 37.932726946744054 in pocket 1911773 10.1021/bi00105a002 1991 ProTherm 321 182 164 S117A Endolysin Enterobacteria phage T4 115.0 3.64 yes 55.29 H3PO4,KH2PO4, 0.0029 M,0.017 M, KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 8.0 1L63, 2LZM 19.37499984105428, 17.96833340326945 in pocket 7869383 10.1006/jmbi.1994.0087 1995 ProTherm HotMuSiC_S1626.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7551 182 164 S117A Endolysin Enterobacteria phage T4 -1.27 yes H3PO4,KH2PO4 0.0029 M, 0.017 M 51.65 KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 8.0 1L63, 2LZM 19.37499984105428, 17.96833340326945 in pocket 7869383 10.1006/jmbi.1994.0087 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, potapov_with_uniprot_mapping.csv 413 228 164 S117F Endolysin Enterobacteria phage T4 104.0 4.8 yes 56.48 H3PO4,KH2PO4, 3 M,17 M, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 8.0 1L63, 2LZM 19.37499984105428, 17.96833340326945 in pocket 8401213 10.1002/pro.5560020811 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 414 228 164 S117F Endolysin Enterobacteria phage T4 132.0 2.8 yes 67.93 Sodium acetate 10 mM NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 8.0 1L63, 2LZM 19.37499984105428, 17.96833340326945 in pocket 8401213 10.1002/pro.5560020811 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 920 228 164 S117F Endolysin Enterobacteria phage T4 3.5 132.0 2.8 yes 68.28 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 8.0 1L63, 2LZM 19.37499984105428, 17.96833340326945 in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6735 228 164 S117F Endolysin Enterobacteria phage T4 3.5 -1.1 yes Acetic acid, Sodium acetate 1.4 mM, 8.6 mM 66.48 NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 8.0 1L63, 2LZM 19.37499984105428, 17.96833340326945 in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 6836 228 164 S117F Endolysin Enterobacteria phage T4 -1.1 yes Sodium acetate 10 mM 65.09 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 8.0 1L63, 2LZM 19.37499984105428, 17.96833340326945 in pocket 8401213 10.1002/pro.5560020811 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 7519 228 164 S117F Endolysin Enterobacteria phage T4 -1.4 yes H3PO4,KH2PO4 3 M,17 M 51.7 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 8.0 1L63, 2LZM 19.37499984105428, 17.96833340326945 in pocket 8401213 10.1002/pro.5560020811 1993 ProTherm capriotti_S1615_map.csv 918 536 164 S117V Endolysin Enterobacteria phage T4 3.5 133.0 5.1 yes 71.58 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 8.0 1L63, 2LZM 19.37499984105428, 17.96833340326945 in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6733 536 164 S117V Endolysin Enterobacteria phage T4 3.5 -2.0 yes Acetic acid, Sodium acetate 1.4 mM, 8.6 mM 66.48 NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 8.0 1L63, 2LZM 19.37499984105428, 17.96833340326945 in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 919 537 164 S117I Endolysin Enterobacteria phage T4 3.5 140.0 4.2 yes 70.68 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 8.0 1L63, 2LZM 19.37499984105428, 17.96833340326945 in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6734 537 164 S117I Endolysin Enterobacteria phage T4 3.5 -1.7 yes Acetic acid, Sodium acetate 1.4 mM, 8.6 mM 66.48 NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 8.0 1L63, 2LZM 19.37499984105428, 17.96833340326945 in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 14481 6722 164 S117A, R119A Endolysin Enterobacteria phage T4 113.0 3.37 yes 55.02 H3PO4,KH2PO4, 0.0029 M,0.017 M, KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 8.0, 4.0 1L63, 2LZM 19.37499984105428, 54.452727404507726, 17.96833340326945, 37.932726946744054 in pocket 7869383 10.1006/jmbi.1994.0087 1995 ProTherm 15021 6722 164 S117A, R119A Endolysin Enterobacteria phage T4 -1.16 yes H3PO4,KH2PO4 0.0029 M, 0.017 M 51.65 KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 8.0, 4.0 1L63, 2LZM 19.37499984105428, 54.452727404507726, 17.96833340326945, 37.932726946744054 in pocket 7869383 10.1006/jmbi.1994.0087 1995 ProTherm 14571 6778 164 S117I, N132M Endolysin Enterobacteria phage T4 3.5 123.0 5.5 yes 71.98 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site, binding site 8.0, 6.0 1L63, 2LZM 19.37499984105428, 18.553750157356262, 17.96833340326945, 16.804999947547913 in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm 14902 6778 164 S117I, N132M Endolysin Enterobacteria phage T4 3.5 -2.0 yes Acetic acid, Sodium acetate 1.4 mM, 8.6 mM 66.48 NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site, binding site 8.0, 6.0 1L63, 2LZM 19.37499984105428, 18.553750157356262, 17.96833340326945, 16.804999947547913 in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm 14572 6779 164 S117I, N132I Endolysin Enterobacteria phage T4 3.5 117.0 3.6 yes 70.08 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site, binding site 8.0, 6.0 1L63, 2LZM 19.37499984105428, 18.553750157356262, 17.96833340326945, 16.804999947547913 in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm 14903 6779 164 S117I, N132I Endolysin Enterobacteria phage T4 3.5 -1.4 yes Acetic acid, Sodium acetate 1.4 mM, 8.6 mM 66.48 NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site, binding site 8.0, 6.0 1L63, 2LZM 19.37499984105428, 18.553750157356262, 17.96833340326945, 16.804999947547913 in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm 14573 6780 164 S117A, N132I Endolysin Enterobacteria phage T4 3.5 121.0 5.3 yes 70.4 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site, binding site 8.0, 6.0 1L63, 2LZM 19.37499984105428, 18.553750157356262, 17.96833340326945, 16.804999947547913 in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm 14916 6780 164 S117A, N132I Endolysin Enterobacteria phage T4 3.5 -2.0 yes Acetic acid, Sodium acetate 1.4 mM, 8.6 mM 65.1 NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site, binding site 8.0, 6.0 1L63, 2LZM 19.37499984105428, 18.553750157356262, 17.96833340326945, 16.804999947547913 in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm 14574 6781 164 S117A, N132M Endolysin Enterobacteria phage T4 3.5 120.0 4.7 yes 69.8 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site, binding site 8.0, 6.0 1L63, 2LZM 19.37499984105428, 18.553750157356262, 17.96833340326945, 16.804999947547913 in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm 14917 6781 164 S117A, N132M Endolysin Enterobacteria phage T4 3.5 -1.8 yes Acetic acid, Sodium acetate 1.4 mM, 8.6 mM 65.1 NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site, binding site 8.0, 6.0 1L63, 2LZM 19.37499984105428, 18.553750157356262, 17.96833340326945, 16.804999947547913 in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm 39 39 164 L118A Endolysin Enterobacteria phage T4 2.5 75.5 -12.2 yes 39.6 Potassium phosphate 0.020 M KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 19.833750009536743, 19.727499961853027 1553543 10.1126/science.1553543 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 322 39 164 L118A Endolysin Enterobacteria phage T4 75.0 -12.05 yes 39.6 H3PO4,KH2PO4, 0.0029 M,0.017 M, KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 19.833750009536743, 19.727499961853027 7869383 10.1006/jmbi.1994.0087 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 2033 39 164 L118A Endolysin Enterobacteria phage T4 109.0 -0.9 Yes(80%) 2.0 56.3 acetic acid, sodium acetate 1.4 mM, 8.6 mM Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 19.833750009536743, 19.727499961853027 10545167 10.1021/bi9915519 1999 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, M47andM8_S1810.csv, SVM-WIN31_SVM-3D12_S1681.csv, EASE-MM_S1676.csv 6800 39 164 L118A Endolysin Enterobacteria phage T4 3.2 Yes(80%) 2.0 acetic acid, sodium acetate 1.4 mM, 8.6 mM 65.3 Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 19.833750009536743, 19.727499961853027 10545167 10.1021/bi9915519 1999 ProTherm khan_protherm_data_mapped.csv 7500 39 164 L118A Endolysin Enterobacteria phage T4 2.5 3.5 yes Potassium phosphate 0.020 M 51.8 KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 19.833750009536743, 19.727499961853027 1553543 10.1126/science.1553543 1992 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 7552 39 164 L118A Endolysin Enterobacteria phage T4 3.5 yes H3PO4,KH2PO4 0.0029 M, 0.017 M 51.65 KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 19.833750009536743, 19.727499961853027 7869383 10.1006/jmbi.1994.0087 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 303 166 164 L118M Endolysin Enterobacteria phage T4 2.5 130.0 -1.8 Unknown 63.5 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 0.1 M CD Thermal 5.42 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 19.833750009536743, 19.727499961853027 8901549 10.1073/pnas.93.22.12155 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6774 166 164 L118M Endolysin Enterobacteria phage T4 2.5 0.7 Unknown Acetic acid,Sodium acetate 1.4 mM,8.6 mM 65.3 NaCl 0.1 M CD Thermal 5.42 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 19.833750009536743, 19.727499961853027 8901549 10.1073/pnas.93.22.12155 1996 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1421 805 164 L118I Endolysin Enterobacteria phage T4 123.0 -3.1 Unknown 62.4 sodium chloride, acetic acid, sodium acetate 0.10 M, 1.4 mM, 8.6 mM CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 19.833750009536743, 19.727499961853027 12963380 10.1016/s0022-2836(03)00856-8 2003 ProTherm 7077 805 164 L118I Endolysin Enterobacteria phage T4 2.5 1.2 Unknown sodium chloride, acetic acid, sodium acetate 0.10 M, 1.4 mM, 8.6 mM 61.0 CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 19.833750009536743, 19.727499961853027 12963380 10.1016/s0022-2836(03)00856-8 2003 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 70 56 164 R119E Endolysin Enterobacteria phage T4 -0.6 yes 50.3 Potassium phosphate 20 mM KCl 25 mM CD Thermal 2.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 54.452727404507726, 37.932726946744054 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm khan_protherm_data_mapped.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 75 56 164 R119E Endolysin Enterobacteria phage T4 0.1 yes 66.6 Potassium phosphate 20 mM KCl 25 mM CD Thermal 5.3 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 54.452727404507726, 37.932726946744054 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm khan_protherm_data_mapped.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6711 56 164 R119E Endolysin Enterobacteria phage T4 0.04 yes Potassium phosphate 20 mM 66.7 KCl 25 mM CD Thermal 5.3 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 54.452727404507726, 37.932726946744054 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 7615 56 164 R119E Endolysin Enterobacteria phage T4 0.2 yes Potassium phosphate 20 mM 50.9 KCl 25 mM CD Thermal 2.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 54.452727404507726, 37.932726946744054 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 11153 56 164 R119E Endolysin Enterobacteria phage T4 0.0 Unknown Potassium phosphate 20 mM 25.0 KCl 25 mM CD Thermal 5.3 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 54.452727404507726, 37.932726946744054 10933506 10.1110/ps.9.7.1395 2000 ProTherm khan_protherm_data_mapped.csv 197 103 164 R119H Endolysin Enterobacteria phage T4 3.5 132.0 -0.74 Unknown 64.41 Sodium acetate 10 mM NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 54.452727404507726, 37.932726946744054 7507755 10.1002/pro.5560021221 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 209 103 164 R119H Endolysin Enterobacteria phage T4 3.5 -0.83 Unknown 61.36 Potassium phosphate 0.01 M KCl 0.15 M CD Thermal 6.78 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 54.452727404507726, 37.932726946744054 7507755 10.1002/pro.5560021221 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6826 103 164 R119H Endolysin Enterobacteria phage T4 3.5 0.29 Unknown Sodium acetate 10 mM 65.15 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 54.452727404507726, 37.932726946744054 7507755 10.1002/pro.5560021221 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 323 183 164 R119A Endolysin Enterobacteria phage T4 107.0 -0.53 yes 51.12 H3PO4,KH2PO4, 0.0029 M,0.017 M, KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 54.452727404507726, 37.932726946744054 7869383 10.1006/jmbi.1994.0087 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7553 183 164 R119A Endolysin Enterobacteria phage T4 0.18 yes H3PO4,KH2PO4 0.0029 M, 0.017 M 51.65 KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 54.452727404507726, 37.932726946744054 7869383 10.1006/jmbi.1994.0087 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3297 1739 164 R119M Endolysin Enterobacteria phage T4 -0.9 yes 40.0 HCl 0.01 N KCl 200 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 54.452727404507726, 37.932726946744054 1911773 10.1021/bi00105a002 1991 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3302 1739 164 R119M Endolysin Enterobacteria phage T4 0.3 yes 66.4 phosphate 10 mM KCl 150 mM CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 54.452727404507726, 37.932726946744054 1911773 10.1021/bi00105a002 1991 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6752 1739 164 R119M Endolysin Enterobacteria phage T4 -0.1 yes phosphate 10 mM 66.1 KCl 150 mM CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 54.452727404507726, 37.932726946744054 1911773 10.1021/bi00105a002 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8066 1739 164 R119M Endolysin Enterobacteria phage T4 0.3 yes HCl 0.01 N 40.9 KCl 200 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 54.452727404507726, 37.932726946744054 1911773 10.1021/bi00105a002 1991 ProTherm capriotti_S1615_map.csv 3626 1881 164 R119C Endolysin Enterobacteria phage T4 -3.0 yes 33.4 Potassium phosphate 20 mM KCl 25 mM CD Thermal 2.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 54.452727404507726, 37.932726946744054 1510962 10.1021/bi00149a004 1992 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, Broom_S605.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 14444 6703 164 R119E, K135E Endolysin Enterobacteria phage T4 -1.5 yes 49.4 Potassium phosphate 20 mM KCl 25 mM CD Thermal 2.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 5.0 1L63, 2LZM 54.452727404507726, 32.19444444444444, 37.932726946744054, 28.960000144110786 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm 14452 6703 164 R119E, K135E Endolysin Enterobacteria phage T4 -2.6 yes 64.1 Potassium phosphate 20 mM KCl 25 mM CD Thermal 5.3 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 5.0 1L63, 2LZM 54.452727404507726, 32.19444444444444, 37.932726946744054, 28.960000144110786 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm 14889 6703 164 R119E, K135E Endolysin Enterobacteria phage T4 1.1 yes Potassium phosphate 20 mM 66.7 KCl 25 mM CD Thermal 5.3 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 5.0 1L63, 2LZM 54.452727404507726, 32.19444444444444, 37.932726946744054, 28.960000144110786 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm 15036 6703 164 R119E, K135E Endolysin Enterobacteria phage T4 0.5 yes Potassium phosphate 20 mM 50.9 KCl 25 mM CD Thermal 2.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 5.0 1L63, 2LZM 54.452727404507726, 32.19444444444444, 37.932726946744054, 28.960000144110786 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm 14447 6706 164 R119E, K135E, K147E Endolysin Enterobacteria phage T4 -0.9 yes 50.0 Potassium phosphate 20 mM KCl 25 mM CD Thermal 2.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 5.0, 3.0 1L63, 2LZM 54.452727404507726, 32.19444444444444, 33.90444416469998, 37.932726946744054, 28.960000144110786, 28.260000122918022 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm 14455 6706 164 R119E, K135E, K147E Endolysin Enterobacteria phage T4 -3.8 yes 62.9 Potassium phosphate 20 mM KCl 25 mM CD Thermal 5.3 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 5.0, 3.0 1L63, 2LZM 54.452727404507726, 32.19444444444444, 33.90444416469998, 37.932726946744054, 28.960000144110786, 28.260000122918022 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm 14892 6706 164 R119E, K135E, K147E Endolysin Enterobacteria phage T4 1.6 yes Potassium phosphate 20 mM 66.7 KCl 25 mM CD Thermal 5.3 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 5.0, 3.0 1L63, 2LZM 54.452727404507726, 32.19444444444444, 33.90444416469998, 37.932726946744054, 28.960000144110786, 28.260000122918022 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm 15039 6706 164 R119E, K135E, K147E Endolysin Enterobacteria phage T4 0.3 yes Potassium phosphate 20 mM 50.9 KCl 25 mM CD Thermal 2.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 5.0, 3.0 1L63, 2LZM 54.452727404507726, 32.19444444444444, 33.90444416469998, 37.932726946744054, 28.960000144110786, 28.260000122918022 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm 14485 6726 164 R119A, Q123A Endolysin Enterobacteria phage T4 110.0 -0.51 yes 51.14 H3PO4,KH2PO4, 0.0029 M,0.017 M, KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 2.0 1L63, 2LZM 54.452727404507726, 33.86555576324463, 37.932726946744054, 29.58888880411784 7869383 10.1006/jmbi.1994.0087 1995 ProTherm 15025 6726 164 R119A, Q123A Endolysin Enterobacteria phage T4 0.17 yes H3PO4,KH2PO4 0.0029 M, 0.017 M 51.65 KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0, 2.0 1L63, 2LZM 54.452727404507726, 33.86555576324463, 37.932726946744054, 29.58888880411784 7869383 10.1006/jmbi.1994.0087 1995 ProTherm 324 184 164 M120A Endolysin Enterobacteria phage T4 112.0 -0.58 yes 51.07 H3PO4,KH2PO4, 0.0029 M,0.017 M, KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 22.607500076293945, 22.941250324249268 in pocket 7869383 10.1006/jmbi.1994.0087 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7554 184 164 M120A Endolysin Enterobacteria phage T4 0.2 yes H3PO4,KH2PO4 0.0029 M, 0.017 M 51.65 KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 22.607500076293945, 22.941250324249268 in pocket 7869383 10.1006/jmbi.1994.0087 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1428 811 164 M120Y Endolysin Enterobacteria phage T4 126.0 -0.1 Unknown 65.4 sodium chloride, acetic acid, sodium acetate 0.10 M, 1.4 mM, 8.6 mM CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 22.607500076293945, 22.941250324249268 in pocket 12963380 10.1016/s0022-2836(03)00856-8 2003 ProTherm 7084 811 164 M120Y Endolysin Enterobacteria phage T4 2.5 0.1 Unknown sodium chloride, acetic acid, sodium acetate 0.10 M, 1.4 mM, 8.6 mM 61.0 CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 22.607500076293945, 22.941250324249268 in pocket 12963380 10.1016/s0022-2836(03)00856-8 2003 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3148 1682 164 M120L Endolysin Enterobacteria phage T4 116.0 1.7 yes (>95%) 53.4 phosphoric acid,Potassium phosphate, 3 mM,17 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 22.607500076293945, 22.941250324249268 in pocket 9541409 10.1002/pro.5560070326 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7813 1682 164 M120L Endolysin Enterobacteria phage T4 1.8 -0.5 yes (>95%) phosphoric acid, Potassium phosphate 3 mM, 17 mM 47.0 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 22.607500076293945, 22.941250324249268 in pocket 9541409 10.1002/pro.5560070326 1998 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3150 1684 164 M120K Endolysin Enterobacteria phage T4 99.0 -4.8 yes (>95%) 46.9 phosphoric acid,Potassium phosphate, 3 mM,17 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 22.607500076293945, 22.941250324249268 in pocket 9541409 10.1002/pro.5560070326 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7815 1684 164 M120K Endolysin Enterobacteria phage T4 1.8 1.6 yes (>95%) phosphoric acid, Potassium phosphate 3 mM, 17 mM 47.0 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 22.607500076293945, 22.941250324249268 in pocket 9541409 10.1002/pro.5560070326 1998 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14482 6723 164 M120A, Q122A Endolysin Enterobacteria phage T4 108.0 -0.75 yes 50.9 H3PO4,KH2PO4, 0.0029 M,0.017 M, KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0, 3.0 1L63, 2LZM 22.607500076293945, 39.32111104329427, 22.941250324249268, 31.825555483500164 in pocket 7869383 10.1006/jmbi.1994.0087 1995 ProTherm 15022 6723 164 M120A, Q122A Endolysin Enterobacteria phage T4 0.25 yes H3PO4,KH2PO4 0.0029 M, 0.017 M 51.65 KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0, 3.0 1L63, 2LZM 22.607500076293945, 39.32111104329427, 22.941250324249268, 31.825555483500164 in pocket 7869383 10.1006/jmbi.1994.0087 1995 ProTherm 40 40 164 L121A Endolysin Enterobacteria phage T4 2.5 81.0 -9.3 yes 42.5 Potassium phosphate 0.020 M KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 17.826250076293945, 18.857499837875366 in pocket 1553543 10.1126/science.1553543 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 307 40 164 L121A Endolysin Enterobacteria phage T4 2.5 110.0 -6.1 yes 59.2 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 17.826250076293945, 18.857499837875366 in pocket 8676387 10.1006/jmbi.1996.0338 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 325 40 164 L121A Endolysin Enterobacteria phage T4 81.0 -9.15 yes 42.5 H3PO4,KH2PO4, 0.0029 M,0.017 M, KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 17.826250076293945, 18.857499837875366 in pocket 7869383 10.1006/jmbi.1994.0087 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 2034 40 164 L121A Endolysin Enterobacteria phage T4 108.0 -6.2 Yes(80%) 2.0 59.1 acetic acid, sodium acetate 1.4 mM, 8.6 mM Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 17.826250076293945, 18.857499837875366 in pocket 10545167 10.1021/bi9915519 1999 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 6778 40 164 L121A Endolysin Enterobacteria phage T4 2.5 2.3 yes Acetic acid,Sodium acetate 1.4 mM,8.6 mM 65.3 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 17.826250076293945, 18.857499837875366 in pocket 8676387 10.1006/jmbi.1996.0338 1996 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, potapov_with_uniprot_mapping.csv 6801 40 164 L121A Endolysin Enterobacteria phage T4 2.2 Yes(80%) 2.0 acetic acid, sodium acetate 1.4 mM, 8.6 mM 65.3 Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 17.826250076293945, 18.857499837875366 in pocket 10545167 10.1021/bi9915519 1999 ProTherm khan_protherm_data_mapped.csv 7501 40 164 L121A Endolysin Enterobacteria phage T4 2.5 2.7 yes Potassium phosphate 0.020 M 51.8 KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 17.826250076293945, 18.857499837875366 in pocket 1553543 10.1126/science.1553543 1992 ProTherm capriotti_S1615_map.csv 7555 40 164 L121A Endolysin Enterobacteria phage T4 2.7 yes H3PO4,KH2PO4 0.0029 M, 0.017 M 51.65 KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 17.826250076293945, 18.857499837875366 in pocket 7869383 10.1006/jmbi.1994.0087 1995 ProTherm capriotti_S1615_map.csv 10025 40 164 L121A Endolysin Enterobacteria phage T4 4.2 10.7 2.6 Unknown Potassium phosphate 20 mM 25.0 NaCl 100 mM CD Urea 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 17.826250076293945, 18.857499837875366 in pocket 17400925 10.1110/ps.062632807 2007 ProTherm SAAFEC_S1262.csv 304 167 164 L121M Endolysin Enterobacteria phage T4 2.5 129.0 -2.1 Unknown 63.2 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 0.1 M CD Thermal 5.42 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 17.826250076293945, 18.857499837875366 in pocket 8901549 10.1073/pnas.93.22.12155 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6775 167 164 L121M Endolysin Enterobacteria phage T4 2.5 0.8 Unknown Acetic acid,Sodium acetate 1.4 mM,8.6 mM 65.3 NaCl 0.1 M CD Thermal 5.42 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 17.826250076293945, 18.857499837875366 in pocket 8901549 10.1073/pnas.93.22.12155 1996 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14477 6718 164 L121A, A129L Endolysin Enterobacteria phage T4 2.5 118.0 -2.8 yes 62.5 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0, 9.0 1L63, 2LZM 17.826250076293945, 17.293999671936035, 18.857499837875366, 17.94600009918213 in pocket 8676387 10.1006/jmbi.1996.0338 1996 ProTherm 14908 6718 164 L121A, A129L Endolysin Enterobacteria phage T4 2.5 1.1 yes Acetic acid,Sodium acetate 1.4 mM,8.6 mM 65.3 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0, 9.0 1L63, 2LZM 17.826250076293945, 17.293999671936035, 18.857499837875366, 17.94600009918213 in pocket 8676387 10.1006/jmbi.1996.0338 1996 ProTherm 14478 6719 164 L121A, A129M Endolysin Enterobacteria phage T4 2.5 121.0 -2.7 yes 62.6 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0, 9.0 1L63, 2LZM 17.826250076293945, 17.293999671936035, 18.857499837875366, 17.94600009918213 in pocket 8676387 10.1006/jmbi.1996.0338 1996 ProTherm 14909 6719 164 L121A, A129M Endolysin Enterobacteria phage T4 2.5 1.0 yes Acetic acid,Sodium acetate 1.4 mM,8.6 mM 65.3 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0, 9.0 1L63, 2LZM 17.826250076293945, 17.293999671936035, 18.857499837875366, 17.94600009918213 in pocket 8676387 10.1006/jmbi.1996.0338 1996 ProTherm 14486 6727 164 L121M, A129L, L133M, V149I, F153W Endolysin Enterobacteria phage T4 yes 51.7 Potassium phosphate 20 mM KCl 0.2 M CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0, 9.0, 7.0, 8.0, 7.0 1L63, 2LZM 17.826250076293945, 17.293999671936035, 17.339999794960022, 15.521428653172084, 18.75727298042991, 18.857499837875366, 17.94600009918213, 14.184999942779541, 9.985714299338204, 15.220908858559348 in pocket 8259514 10.1126/science.8259514 1993 ProTherm 15010 6727 164 L121M, A129L, L133M, V149I, F153W Endolysin Enterobacteria phage T4 1.3 yes Potassium phosphate 20 mM 51.7 KCl 0.2 M CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0, 9.0, 7.0, 8.0, 7.0 1L63, 2LZM 17.826250076293945, 17.293999671936035, 17.339999794960022, 15.521428653172084, 18.75727298042991, 18.857499837875366, 17.94600009918213, 14.184999942779541, 9.985714299338204, 15.220908858559348 in pocket 8259514 10.1126/science.8259514 1993 ProTherm 14487 6728 164 L121I, A129L, L133M, F153W Endolysin Enterobacteria phage T4 yes 51.7 Potassium phosphate 20 mM KCl 0.2 M CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0, 9.0, 7.0, 7.0 1L63, 2LZM 17.826250076293945, 17.293999671936035, 17.339999794960022, 18.75727298042991, 18.857499837875366, 17.94600009918213, 14.184999942779541, 15.220908858559348 in pocket 8259514 10.1126/science.8259514 1993 ProTherm 15011 6728 164 L121I, A129L, L133M, F153W Endolysin Enterobacteria phage T4 1.3 yes Potassium phosphate 20 mM 51.7 KCl 0.2 M CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0, 9.0, 7.0, 7.0 1L63, 2LZM 17.826250076293945, 17.293999671936035, 17.339999794960022, 18.75727298042991, 18.857499837875366, 17.94600009918213, 14.184999942779541, 15.220908858559348 in pocket 8259514 10.1126/science.8259514 1993 ProTherm 14488 6729 164 L121A, A129M, V149I Endolysin Enterobacteria phage T4 yes 51.7 Potassium phosphate 20 mM KCl 0.2 M CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0, 9.0, 8.0 1L63, 2LZM 17.826250076293945, 17.293999671936035, 15.521428653172084, 18.857499837875366, 17.94600009918213, 9.985714299338204 in pocket 8259514 10.1126/science.8259514 1993 ProTherm 15012 6729 164 L121A, A129M, V149I Endolysin Enterobacteria phage T4 1.4 yes Potassium phosphate 20 mM 51.7 KCl 0.2 M CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0, 9.0, 8.0 1L63, 2LZM 17.826250076293945, 17.293999671936035, 15.521428653172084, 18.857499837875366, 17.94600009918213, 9.985714299338204 in pocket 8259514 10.1126/science.8259514 1993 ProTherm 14489 6730 164 L121I, A129W, L133M Endolysin Enterobacteria phage T4 yes 51.7 Potassium phosphate KCl 0.2 M CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0, 9.0, 7.0 1L63, 2LZM 17.826250076293945, 17.293999671936035, 17.339999794960022, 18.857499837875366, 17.94600009918213, 14.184999942779541 in pocket 8259514 10.1126/science.8259514 1993 ProTherm 15013 6730 164 L121I, A129W, L133M Endolysin Enterobacteria phage T4 1.4 yes Potassium phosphate 20 mM 51.7 KCl 0.2 M CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0, 9.0, 7.0 1L63, 2LZM 17.826250076293945, 17.293999671936035, 17.339999794960022, 18.857499837875366, 17.94600009918213, 14.184999942779541 in pocket 8259514 10.1126/science.8259514 1993 ProTherm 14490 6731 164 L121A, A129V, L133M, F153L Endolysin Enterobacteria phage T4 yes 51.7 Potassium phosphate 20 mM KCl 0.2 M CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0, 9.0, 7.0, 7.0 1L63, 2LZM 17.826250076293945, 17.293999671936035, 17.339999794960022, 18.75727298042991, 18.857499837875366, 17.94600009918213, 14.184999942779541, 15.220908858559348 in pocket 8259514 10.1126/science.8259514 1993 ProTherm 15014 6731 164 L121A, A129V, L133M, F153L Endolysin Enterobacteria phage T4 2.3 yes Potassium phosphate 20 mM 51.7 KCl 0.2 M CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0, 9.0, 7.0, 7.0 1L63, 2LZM 17.826250076293945, 17.293999671936035, 17.339999794960022, 18.75727298042991, 18.857499837875366, 17.94600009918213, 14.184999942779541, 15.220908858559348 in pocket 8259514 10.1126/science.8259514 1993 ProTherm 14491 6732 164 L121M, L133V, F153L Endolysin Enterobacteria phage T4 yes 51.7 Potassium phosphate 20 mM KCl 0.2 M CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0, 7.0, 7.0 1L63, 2LZM 17.826250076293945, 17.339999794960022, 18.75727298042991, 18.857499837875366, 14.184999942779541, 15.220908858559348 in pocket 8259514 10.1126/science.8259514 1993 ProTherm 15015 6732 164 L121M, L133V, F153L Endolysin Enterobacteria phage T4 2.5 yes Potassium phosphate 20 mM 51.7 KCl 0.2 M CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0, 7.0, 7.0 1L63, 2LZM 17.826250076293945, 17.339999794960022, 18.75727298042991, 18.857499837875366, 14.184999942779541, 15.220908858559348 in pocket 8259514 10.1126/science.8259514 1993 ProTherm 14492 6733 164 L121A, A129L, L133A, F153L Endolysin Enterobacteria phage T4 yes 51.7 Potassium phosphate 20 mM KCl 0.2 M CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0, 9.0, 7.0, 7.0 1L63, 2LZM 17.826250076293945, 17.293999671936035, 17.339999794960022, 18.75727298042991, 18.857499837875366, 17.94600009918213, 14.184999942779541, 15.220908858559348 in pocket 8259514 10.1126/science.8259514 1993 ProTherm 15016 6733 164 L121A, A129L, L133A, F153L Endolysin Enterobacteria phage T4 3.5 yes Potassium phosphate 20 mM 51.7 KCl 0.2 M CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0, 9.0, 7.0, 7.0 1L63, 2LZM 17.826250076293945, 17.293999671936035, 17.339999794960022, 18.75727298042991, 18.857499837875366, 17.94600009918213, 14.184999942779541, 15.220908858559348 in pocket 8259514 10.1126/science.8259514 1993 ProTherm 15009 6982 164 L121A, A129M, F153L Endolysin Enterobacteria phage T4 1.1 yes Potassium phosphate 20 mM 51.7 KCl 0.2 M CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0, 9.0, 7.0 1L63, 2LZM 17.826250076293945, 17.293999671936035, 18.75727298042991, 18.857499837875366, 17.94600009918213, 15.220908858559348 in pocket 8259514 10.1126/science.8259514 1993 ProTherm 326 185 164 Q122A Endolysin Enterobacteria phage T4 108.0 -0.71 yes 50.94 H3PO4,KH2PO4, 0.0029 M,0.017 M, KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 39.32111104329427, 31.825555483500164 7869383 10.1006/jmbi.1994.0087 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7556 185 164 Q122A Endolysin Enterobacteria phage T4 0.24 yes H3PO4,KH2PO4 0.0029 M, 0.017 M 51.65 KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 39.32111104329427, 31.825555483500164 7869383 10.1006/jmbi.1994.0087 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 327 186 164 Q123A Endolysin Enterobacteria phage T4 111.0 -0.64 yes 51.01 H3PO4,KH2PO4, 0.0029 M,0.017 M, KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 33.86555576324463, 29.58888880411784 7869383 10.1006/jmbi.1994.0087 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7557 186 164 Q123A Endolysin Enterobacteria phage T4 0.22 yes H3PO4,KH2PO4 0.0029 M, 0.017 M 51.65 KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 33.86555576324463, 29.58888880411784 7869383 10.1006/jmbi.1994.0087 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3407 1773 164 Q123E Endolysin Enterobacteria phage T4 82.0 1.0 yes 41.4 HCl 10 mM KCl 0.15 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 33.86555576324463, 29.58888880411784 1854726 10.1021/bi00243a015 1991 ProTherm AUTOMUTE_S1962.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3408 1773 164 Q123E Endolysin Enterobacteria phage T4 113.0 0.2 yes 66.9 acetate 10 mM KCl 0.15 M CD Thermal 5.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 33.86555576324463, 29.58888880411784 1854726 10.1021/bi00243a015 1991 ProTherm PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3409 1773 164 Q123E Endolysin Enterobacteria phage T4 132.0 1.2 yes 65.8 Potassium phosphate 10 mM KCl 0.15 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 33.86555576324463, 29.58888880411784 1854726 10.1021/bi00243a015 1991 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6716 1773 164 Q123E Endolysin Enterobacteria phage T4 -0.1 yes acetate 10 mM 66.7 KCl 0.15 M CD Thermal 5.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 33.86555576324463, 29.58888880411784 1854726 10.1021/bi00243a015 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 7021 1773 164 Q123E Endolysin Enterobacteria phage T4 -0.4 yes Potassium phosphate 10 mM 64.5 KCl 0.15 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 33.86555576324463, 29.58888880411784 1854726 10.1021/bi00243a015 1991 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, potapov_with_uniprot_mapping.csv 8079 1773 164 Q123E Endolysin Enterobacteria phage T4 -0.3 yes HCl 10 mM 40.4 KCl 0.15 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 33.86555576324463, 29.58888880411784 1854726 10.1021/bi00243a015 1991 ProTherm capriotti_S1615_map.csv 704 433 164 K124G Endolysin Enterobacteria phage T4 0.0 yes 41.9 KH2PO4 100 mM KCl 100 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 18.819999906751846, 15.973333252800835 2511328 10.1016/0022-2836(89)90299-4 1989 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 706 433 164 K124G Endolysin Enterobacteria phage T4 -0.2 yes 64.5 KH2PO4 100 mM KCl 100 mM CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 18.819999906751846, 15.973333252800835 2511328 10.1016/0022-2836(89)90299-4 1989 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6984 433 164 K124G Endolysin Enterobacteria phage T4 0.1 yes KH2PO4 100 mM 64.7 KCl 100 mM CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 18.819999906751846, 15.973333252800835 2511328 10.1016/0022-2836(89)90299-4 1989 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8032 433 164 K124G Endolysin Enterobacteria phage T4 0.0 yes KH2PO4 100 mM 41.9 KCl 100 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 4.0 1L63, 2LZM 18.819999906751846, 15.973333252800835 2511328 10.1016/0022-2836(89)90299-4 1989 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv 12617 5835 164 W126R Endolysin Enterobacteria phage T4 3.4 5.74 Unknown imidazole,MOPS, 0.05 M,0.05 M, 22.0 Gel electrophoresis Urea 7.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 17.497142791748047, 19.101428372519358 in pocket 1988046 10.1021/bi00216a038 1991 ProTherm SAAFEC_S1262.csv 14466 6713 164 W138Y, W126Y, W158Y Endolysin Enterobacteria phage T4 2.1 113.0 Unknown 46.85 Unknown CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0, 9.0, 5.0 1L63, 2LZM 17.497142791748047, 16.036428587777273, 20.193571499415807, 19.101428372519358, 14.857142925262451, 20.82714285169329 in tunnel in pocket 7306671 10.1002/bip.1981.360200921 1981 ProTherm 14467 6713 164 W138Y, W126Y, W158Y Endolysin Enterobacteria phage T4 2.1 -7.0 Unknown 30.0 Unknown CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0, 9.0, 5.0 1L63, 2LZM 17.497142791748047, 16.036428587777273, 20.193571499415807, 19.101428372519358, 14.857142925262451, 20.82714285169329 in tunnel in pocket 7306671 10.1002/bip.1981.360200921 1981 ProTherm 14511 6713 164 W138Y, W126Y, W158Y Endolysin Enterobacteria phage T4 85.3 -6.6 yes 36.0 Sodium phosphate 0.2 M NaCl 0.5 M CD Thermal 2.2 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0, 9.0, 5.0 1L63, 2LZM 17.497142791748047, 16.036428587777273, 20.193571499415807, 19.101428372519358, 14.857142925262451, 20.82714285169329 in tunnel in pocket 911878 10.1016/0005-2795(77)90166-0 1977 ProTherm 14512 6713 164 W138Y, W126Y, W158Y Endolysin Enterobacteria phage T4 89.2 -6.2 yes 40.0 Sodium phosphate 0.2 M NaCl 0.5 M CD Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0, 9.0, 5.0 1L63, 2LZM 17.497142791748047, 16.036428587777273, 20.193571499415807, 19.101428372519358, 14.857142925262451, 20.82714285169329 in tunnel in pocket 911878 10.1016/0005-2795(77)90166-0 1977 ProTherm 14513 6713 164 W138Y, W126Y, W158Y Endolysin Enterobacteria phage T4 1.82 85.3 -6.6 yes 36.0 Sodium phosphate 0.2 M NaCl 0.5 M CD Thermal 2.2 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0, 9.0, 5.0 1L63, 2LZM 17.497142791748047, 16.036428587777273, 20.193571499415807, 19.101428372519358, 14.857142925262451, 20.82714285169329 in tunnel in pocket 911878 10.1016/0005-2795(77)90166-0 1977 ProTherm 14514 6713 164 W138Y, W126Y, W158Y Endolysin Enterobacteria phage T4 1.77 89.2 -6.2 yes 40.0 Sodium phosphate 0.2 M NaCl 0.5 M CD Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0, 9.0, 5.0 1L63, 2LZM 17.497142791748047, 16.036428587777273, 20.193571499415807, 19.101428372519358, 14.857142925262451, 20.82714285169329 in tunnel in pocket 911878 10.1016/0005-2795(77)90166-0 1977 ProTherm 14517 6745 164 D127A, E128A Endolysin Enterobacteria phage T4 2.4 85.8 0.9 yes 41.65 Unknown KCl 0.2 M CD Thermal 2.02 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0, 1.0 1L63, 2LZM 25.588749885559082, 46.15444416469998, 25.15374982357025, 30.945555051167805 1304917 10.1002/pro.5560010608 1992 ProTherm 15102 6745 164 D127A, E128A Endolysin Enterobacteria phage T4 2.4 -0.24 yes Unknown 40.75 KCl 0.2 M CD Thermal 2.02 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0, 1.0 1L63, 2LZM 25.588749885559082, 46.15444416469998, 25.15374982357025, 30.945555051167805 1304917 10.1002/pro.5560010608 1992 ProTherm 14521 6749 164 D127A, E128A, V131A, N132A Endolysin Enterobacteria phage T4 2.4 86.3 4.0 yes 44.75 Unknown KCl 0.2 M CD Thermal 2.02 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 1.0, 1.0, 2.0, 6.0 1L63, 2LZM 25.588749885559082, 46.15444416469998, 22.488571166992188, 18.553750157356262, 25.15374982357025, 30.945555051167805, 16.635714530944824, 16.804999947547913 in pocket 1304917 10.1002/pro.5560010608 1992 ProTherm 15106 6749 164 D127A, E128A, V131A, N132A Endolysin Enterobacteria phage T4 2.4 -1.01 yes Unknown 40.75 KCl 0.2 M CD Thermal 2.02 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 1.0, 1.0, 2.0, 6.0 1L63, 2LZM 25.588749885559082, 46.15444416469998, 22.488571166992188, 18.553750157356262, 25.15374982357025, 30.945555051167805, 16.635714530944824, 16.804999947547913 in pocket 1304917 10.1002/pro.5560010608 1992 ProTherm 15784 6749 164 D127A, E128A, V131A, N132A Endolysin Enterobacteria phage T4 1.8 129.0 2.4 yes(>90%) 55.8 KPO4 20.0 mM KCl 25.0 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 1.0, 1.0, 2.0, 6.0 1L63, 2LZM 25.588749885559082, 46.15444416469998, 22.488571166992188, 18.553750157356262, 25.15374982357025, 30.945555051167805, 16.635714530944824, 16.804999947547913 in pocket 12487988 10.1016/s0301-4622(02)00193-x 2002 ProTherm 16776 6749 164 D127A, E128A, V131A, N132A Endolysin Enterobacteria phage T4 1.8 -0.85 yes(>90%) KPO4 20.0 mM 53.4 KCl 25.0 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 1.0, 1.0, 2.0, 6.0 1L63, 2LZM 25.588749885559082, 46.15444416469998, 22.488571166992188, 18.553750157356262, 25.15374982357025, 30.945555051167805, 16.635714530944824, 16.804999947547913 in pocket 12487988 10.1016/s0301-4622(02)00193-x 2002 ProTherm 14523 6751 164 D127A, E128A, V131A, N132A, L133A Endolysin Enterobacteria phage T4 2.4 62.2 -9.4 yes 31.35 Unknown KCl 0.2 M CD Thermal 2.02 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 1.0, 1.0, 2.0, 6.0, 7.0 1L63, 2LZM 25.588749885559082, 46.15444416469998, 22.488571166992188, 18.553750157356262, 17.339999794960022, 25.15374982357025, 30.945555051167805, 16.635714530944824, 16.804999947547913, 14.184999942779541 in pocket 1304917 10.1002/pro.5560010608 1992 ProTherm 15108 6751 164 D127A, E128A, V131A, N132A, L133A Endolysin Enterobacteria phage T4 2.4 2.27 yes Unknown 40.75 KCl 0.2 M CD Thermal 2.02 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 1.0, 1.0, 2.0, 6.0, 7.0 1L63, 2LZM 25.588749885559082, 46.15444416469998, 22.488571166992188, 18.553750157356262, 17.339999794960022, 25.15374982357025, 30.945555051167805, 16.635714530944824, 16.804999947547913, 14.184999942779541 in pocket 1304917 10.1002/pro.5560010608 1992 ProTherm 15786 6751 164 D127A, E128A, V131A, N132A, L133A Endolysin Enterobacteria phage T4 1.8 103.0 -7.0 yes(>90%) 46.4 KPO4 20.0 mM KCl 25.0 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 1.0, 1.0, 2.0, 6.0, 7.0 1L63, 2LZM 25.588749885559082, 46.15444416469998, 22.488571166992188, 18.553750157356262, 17.339999794960022, 25.15374982357025, 30.945555051167805, 16.635714530944824, 16.804999947547913, 14.184999942779541 in pocket 12487988 10.1016/s0301-4622(02)00193-x 2002 ProTherm 16778 6751 164 D127A, E128A, V131A, N132A, L133A Endolysin Enterobacteria phage T4 1.8 2.5 yes(>90%) KPO4 20.0 mM 53.4 KCl 25.0 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 1.0, 1.0, 2.0, 6.0, 7.0 1L63, 2LZM 25.588749885559082, 46.15444416469998, 22.488571166992188, 18.553750157356262, 17.339999794960022, 25.15374982357025, 30.945555051167805, 16.635714530944824, 16.804999947547913, 14.184999942779541 in pocket 12487988 10.1016/s0301-4622(02)00193-x 2002 ProTherm 15787 7393 164 D127A, E128A, V131A, N132A, K135A, S136A, Y139A, N140A, Q141A Endolysin Enterobacteria phage T4 1.8 103.0 -0.8 yes(>90%) 52.6 KPO4 20.0 mM KCl 25.0 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 1.0, 1.0, 2.0, 6.0, 5.0, 9.0, 7.0, 4.0, 9.0 1L63, 2LZM 25.588749885559082, 46.15444416469998, 22.488571166992188, 18.553750157356262, 32.19444444444444, 15.333333492279053, 26.602500200271606, 21.761250138282776, 27.74111090766059, 25.15374982357025, 30.945555051167805, 16.635714530944824, 16.804999947547913, 28.960000144110786, 13.519999980926514, 22.97166673342387, 20.59750008583069, 25.478888723585342 in tunnel in pocket 12487988 10.1016/s0301-4622(02)00193-x 2002 ProTherm 16780 7393 164 D127A, E128A, V131A, N132A, K135A, S136A, Y139A, N140A, Q141A Endolysin Enterobacteria phage T4 1.8 0.5 yes(>90%) KPO4 20.0 mM 53.4 KCl 25.0 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 1.0, 1.0, 2.0, 6.0, 5.0, 9.0, 7.0, 4.0, 9.0 1L63, 2LZM 25.588749885559082, 46.15444416469998, 22.488571166992188, 18.553750157356262, 32.19444444444444, 15.333333492279053, 26.602500200271606, 21.761250138282776, 27.74111090766059, 25.15374982357025, 30.945555051167805, 16.635714530944824, 16.804999947547913, 28.960000144110786, 13.519999980926514, 22.97166673342387, 20.59750008583069, 25.478888723585342 in tunnel in pocket 12487988 10.1016/s0301-4622(02)00193-x 2002 ProTherm 16779 7889 164 D127A, E128A, V131A, N132A, K135A, S136A Endolysin Enterobacteria phage T4 1.8 0.5 yes(>90%) KPO4 20.0 mM 53.4 KCl 25.0 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 1.0, 1.0, 2.0, 6.0, 5.0, 9.0 1L63, 2LZM 25.588749885559082, 46.15444416469998, 22.488571166992188, 18.553750157356262, 32.19444444444444, 15.333333492279053, 25.15374982357025, 30.945555051167805, 16.635714530944824, 16.804999947547913, 28.960000144110786, 13.519999980926514 in pocket 12487988 10.1016/s0301-4622(02)00193-x 2002 ProTherm 245 133 164 E128K Endolysin Enterobacteria phage T4 2.25 78.5 Unknown 46.85 Unknown CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 46.15444416469998, 30.945555051167805 7306671 10.1002/bip.1981.360200921 1981 ProTherm 250 133 164 E128K Endolysin Enterobacteria phage T4 2.25 -5.0 Unknown 54.0 Unknown CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 46.15444416469998, 30.945555051167805 7306671 10.1002/bip.1981.360200921 1981 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 477 133 164 E128K Endolysin Enterobacteria phage T4 5.3 yes 51.5 Unknown NaCl 0.2 M CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 46.15444416469998, 30.945555051167805 6726809 10.1016/0022-2836(84)90474-1 1984 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7796 133 164 E128K Endolysin Enterobacteria phage T4 1.16 1.19 yes Unknown 47.0 NaCl 0.2 M CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 46.15444416469998, 30.945555051167805 6726809 10.1016/0022-2836(84)90474-1 1984 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 582 333 164 E128A Endolysin Enterobacteria phage T4 2.4 85.0 0.6 yes 41.35 Unknown KCl 0.2 M CD Thermal 2.02 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 46.15444416469998, 30.945555051167805 1304917 10.1002/pro.5560010608 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3498 333 164 E128A Endolysin Enterobacteria phage T4 85.0 0.6 yes 41.4 HCl KCl 0.20 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 46.15444416469998, 30.945555051167805 1998663 10.1021/bi00222a001 1991 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8068 333 164 E128A Endolysin Enterobacteria phage T4 -0.16 yes HCl 40.8 KCl 0.20 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 46.15444416469998, 30.945555051167805 1998663 10.1021/bi00222a001 1991 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8070 333 164 E128A Endolysin Enterobacteria phage T4 2.4 -0.16 yes Unknown 40.75 KCl 0.2 M CD Thermal 2.02 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0 1L63, 2LZM 46.15444416469998, 30.945555051167805 1304917 10.1002/pro.5560010608 1992 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14518 6746 164 E128A, V131A Endolysin Enterobacteria phage T4 2.4 93.0 1.5 yes 42.25 Unknown KCl 0.2 M CD Thermal 2.02 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0, 2.0 1L63, 2LZM 46.15444416469998, 22.488571166992188, 30.945555051167805, 16.635714530944824 in pocket 1304917 10.1002/pro.5560010608 1992 ProTherm 14718 6746 164 E128A, V131A Endolysin Enterobacteria phage T4 93.0 1.5 yes 42.3 HCl KCl 0.20 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0, 2.0 1L63, 2LZM 46.15444416469998, 22.488571166992188, 30.945555051167805, 16.635714530944824 in pocket 1998663 10.1021/bi00222a001 1991 ProTherm 15099 6746 164 E128A, V131A Endolysin Enterobacteria phage T4 -0.41 yes HCl 40.8 KCl 0.20 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0, 2.0 1L63, 2LZM 46.15444416469998, 22.488571166992188, 30.945555051167805, 16.635714530944824 in pocket 1998663 10.1021/bi00222a001 1991 ProTherm 15103 6746 164 E128A, V131A Endolysin Enterobacteria phage T4 2.4 -0.44 yes Unknown 40.75 KCl 0.2 M CD Thermal 2.02 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 1.0, 2.0 1L63, 2LZM 46.15444416469998, 22.488571166992188, 30.945555051167805, 16.635714530944824 in pocket 1304917 10.1002/pro.5560010608 1992 ProTherm 14520 6748 164 E128A, V131A, N132A Endolysin Enterobacteria phage T4 2.4 88.3 3.4 yes 44.15 Unknown KCl 0.2 M CD Thermal 2.02 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 1.0, 2.0, 6.0 1L63, 2LZM 46.15444416469998, 22.488571166992188, 18.553750157356262, 30.945555051167805, 16.635714530944824, 16.804999947547913 in pocket 1304917 10.1002/pro.5560010608 1992 ProTherm 14720 6748 164 E128A, V131A, N132A Endolysin Enterobacteria phage T4 88.3 3.4 yes 44.2 HCl KCl 0.20 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 1.0, 2.0, 6.0 1L63, 2LZM 46.15444416469998, 22.488571166992188, 18.553750157356262, 30.945555051167805, 16.635714530944824, 16.804999947547913 in pocket 1998663 10.1021/bi00222a001 1991 ProTherm 15101 6748 164 E128A, V131A, N132A Endolysin Enterobacteria phage T4 -0.94 yes HCl 40.8 KCl 0.20 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 1.0, 2.0, 6.0 1L63, 2LZM 46.15444416469998, 22.488571166992188, 18.553750157356262, 30.945555051167805, 16.635714530944824, 16.804999947547913 in pocket 1998663 10.1021/bi00222a001 1991 ProTherm 15105 6748 164 E128A, V131A, N132A Endolysin Enterobacteria phage T4 2.4 -0.91 yes Unknown 40.75 KCl 0.2 M CD Thermal 2.02 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 1.0, 2.0, 6.0 1L63, 2LZM 46.15444416469998, 22.488571166992188, 18.553750157356262, 30.945555051167805, 16.635714530944824, 16.804999947547913 in pocket 1304917 10.1002/pro.5560010608 1992 ProTherm 15783 6748 164 E128A, V131A, N132A Endolysin Enterobacteria phage T4 1.8 137.0 2.2 yes(>90%) 55.6 KPO4 20.0 mM KCl 25.0 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 1.0, 2.0, 6.0 1L63, 2LZM 46.15444416469998, 22.488571166992188, 18.553750157356262, 30.945555051167805, 16.635714530944824, 16.804999947547913 in pocket 12487988 10.1016/s0301-4622(02)00193-x 2002 ProTherm 16775 6748 164 E128A, V131A, N132A Endolysin Enterobacteria phage T4 1.8 -0.9 yes(>90%) KPO4 20.0 mM 53.4 KCl 25.0 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 1.0, 2.0, 6.0 1L63, 2LZM 46.15444416469998, 22.488571166992188, 18.553750157356262, 30.945555051167805, 16.635714530944824, 16.804999947547913 in pocket 12487988 10.1016/s0301-4622(02)00193-x 2002 ProTherm 14522 6750 164 E128A, V131A, N132A, L133A Endolysin Enterobacteria phage T4 2.4 63.9 -10.3 yes 30.45 Unknown KCl 0.2 M CD Thermal 2.02 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 1.0, 2.0, 6.0, 7.0 1L63, 2LZM 46.15444416469998, 22.488571166992188, 18.553750157356262, 17.339999794960022, 30.945555051167805, 16.635714530944824, 16.804999947547913, 14.184999942779541 in pocket 1304917 10.1002/pro.5560010608 1992 ProTherm 15107 6750 164 E128A, V131A, N132A, L133A Endolysin Enterobacteria phage T4 2.4 2.59 yes Unknown 40.75 KCl 0.2 M CD Thermal 2.02 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 1.0, 2.0, 6.0, 7.0 1L63, 2LZM 46.15444416469998, 22.488571166992188, 18.553750157356262, 17.339999794960022, 30.945555051167805, 16.635714530944824, 16.804999947547913, 14.184999942779541 in pocket 1304917 10.1002/pro.5560010608 1992 ProTherm 15785 6750 164 E128A, V131A, N132A, L133A Endolysin Enterobacteria phage T4 1.8 102.0 -7.0 yes(>90%) 46.4 KPO4 20.0 mM KCl 25.0 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 1.0, 2.0, 6.0, 7.0 1L63, 2LZM 46.15444416469998, 22.488571166992188, 18.553750157356262, 17.339999794960022, 30.945555051167805, 16.635714530944824, 16.804999947547913, 14.184999942779541 in pocket 12487988 10.1016/s0301-4622(02)00193-x 2002 ProTherm 16777 6750 164 E128A, V131A, N132A, L133A Endolysin Enterobacteria phage T4 1.8 2.5 yes(>90%) KPO4 20.0 mM 53.4 KCl 25.0 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 1.0, 2.0, 6.0, 7.0 1L63, 2LZM 46.15444416469998, 22.488571166992188, 18.553750157356262, 17.339999794960022, 30.945555051167805, 16.635714530944824, 16.804999947547913, 14.184999942779541 in pocket 12487988 10.1016/s0301-4622(02)00193-x 2002 ProTherm 15788 7394 164 E128A, V131A, N132A, K135A, S136A, Y139A, N140A, Q141A Endolysin Enterobacteria phage T4 1.8 102.0 -0.9 yes(>90%) 52.5 KPO4 20.0 mM KCl 25.0 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 1.0, 2.0, 6.0, 5.0, 9.0, 7.0, 4.0, 9.0 1L63, 2LZM 46.15444416469998, 22.488571166992188, 18.553750157356262, 32.19444444444444, 15.333333492279053, 26.602500200271606, 21.761250138282776, 27.74111090766059, 30.945555051167805, 16.635714530944824, 16.804999947547913, 28.960000144110786, 13.519999980926514, 22.97166673342387, 20.59750008583069, 25.478888723585342 in tunnel in pocket 12487988 10.1016/s0301-4622(02)00193-x 2002 ProTherm 16781 7394 164 E128A, V131A, N132A, K135A, S136A, Y139A, N140A, Q141A Endolysin Enterobacteria phage T4 1.8 0.5 yes(>90%) KPO4 20.0 mM 53.4 KCl 25.0 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 1.0, 2.0, 6.0, 5.0, 9.0, 7.0, 4.0, 9.0 1L63, 2LZM 46.15444416469998, 22.488571166992188, 18.553750157356262, 32.19444444444444, 15.333333492279053, 26.602500200271606, 21.761250138282776, 27.74111090766059, 30.945555051167805, 16.635714530944824, 16.804999947547913, 28.960000144110786, 13.519999980926514, 22.97166673342387, 20.59750008583069, 25.478888723585342 in tunnel in pocket 12487988 10.1016/s0301-4622(02)00193-x 2002 ProTherm 308 170 164 A129L Endolysin Enterobacteria phage T4 2.5 112.0 -3.2 yes 62.1 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.293999671936035, 17.94600009918213 in pocket 8676387 10.1006/jmbi.1996.0338 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3784 170 164 A129L Endolysin Enterobacteria phage T4 94.0 -2.9 yes 49.1 phosphoric acid,Potassium phosphate, 3 mM,17 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.293999671936035, 17.94600009918213 in pocket 10623513 10.1006/jmbi.1999.3300 2000 ProTherm EASE-MM_S543.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6779 170 164 A129L Endolysin Enterobacteria phage T4 2.5 1.3 yes Acetic acid,Sodium acetate 1.4 mM,8.6 mM 65.3 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.293999671936035, 17.94600009918213 in pocket 8676387 10.1006/jmbi.1996.0338 1996 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 309 171 164 A129M Endolysin Enterobacteria phage T4 2.5 110.0 -5.2 yes 60.1 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.293999671936035, 17.94600009918213 in pocket 8676387 10.1006/jmbi.1996.0338 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 2046 171 164 A129M Endolysin Enterobacteria phage T4 109.0 -5.2 Yes(80%) 2.0 60.1 acetic acid, sodium acetate 1.4 mM, 8.6 mM Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.293999671936035, 17.94600009918213 in pocket 10545167 10.1021/bi9915519 1999 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 3785 171 164 A129M Endolysin Enterobacteria phage T4 85.0 -5.5 yes 46.2 phosphoric acid,Potassium phosphate, 3 mM,17 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.293999671936035, 17.94600009918213 in pocket 10623513 10.1006/jmbi.1999.3300 2000 ProTherm EASE-MM_S543.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6780 171 164 A129M Endolysin Enterobacteria phage T4 2.5 1.9 yes Acetic acid,Sodium acetate 1.4 mM,8.6 mM 65.3 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.293999671936035, 17.94600009918213 in pocket 8676387 10.1006/jmbi.1996.0338 1996 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 6813 171 164 A129M Endolysin Enterobacteria phage T4 1.9 Yes(80%) 2.0 acetic acid, sodium acetate 1.4 mM, 8.6 mM 65.3 Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.293999671936035, 17.94600009918213 in pocket 10545167 10.1021/bi9915519 1999 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 708 435 164 A129V Endolysin Enterobacteria phage T4 78.0 -2.9 yes 38.5 Unknown KCl 0.2 M CD Thermal 1.99 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.293999671936035, 17.94600009918213 in pocket 2682639 10.1073/pnas.86.21.8237 1989 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, HotMuSiC_S1626.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 710 435 164 A129V Endolysin Enterobacteria phage T4 -1.9 yes 50.2 Unknown KCl 0.2 M CD Thermal 2.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.293999671936035, 17.94600009918213 in pocket 2682639 10.1073/pnas.86.21.8237 1989 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7463 435 164 A129V Endolysin Enterobacteria phage T4 0.7 yes Unknown 52.1 KCl 0.2 M CD Thermal 2.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.293999671936035, 17.94600009918213 in pocket 2682639 10.1073/pnas.86.21.8237 1989 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8056 435 164 A129V Endolysin Enterobacteria phage T4 0.8 yes Unknown 41.4 KCl 0.2 M CD Thermal 1.99 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.293999671936035, 17.94600009918213 in pocket 2682639 10.1073/pnas.86.21.8237 1989 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 3786 1966 164 A129F Endolysin Enterobacteria phage T4 94.0 -2.3 yes 49.4 phosphoric acid,Potassium phosphate, 3 mM,17 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.293999671936035, 17.94600009918213 in pocket 10623513 10.1006/jmbi.1999.3300 2000 ProTherm STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3787 1967 164 A129W Endolysin Enterobacteria phage T4 80.0 -5.1 yes 46.6 phosphoric acid,Potassium phosphate, 3 mM,17 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.293999671936035, 17.94600009918213 in pocket 10623513 10.1006/jmbi.1999.3300 2000 ProTherm STRUM_Q3421.csv, EASE-MM_S543.csv, PoPMuSiC-2.0_S2648.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 14479 6720 164 A129M, F153A Endolysin Enterobacteria phage T4 2.5 94.0 -12.7 yes 52.6 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0, 7.0 1L63, 2LZM 17.293999671936035, 18.75727298042991, 17.94600009918213, 15.220908858559348 in pocket 8676387 10.1006/jmbi.1996.0338 1996 ProTherm 14910 6720 164 A129M, F153A Endolysin Enterobacteria phage T4 2.5 4.3 yes Acetic acid,Sodium acetate 1.4 mM,8.6 mM 65.3 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0, 7.0 1L63, 2LZM 17.293999671936035, 18.75727298042991, 17.94600009918213, 15.220908858559348 in pocket 8676387 10.1006/jmbi.1996.0338 1996 ProTherm 422 236 164 A130S Endolysin Enterobacteria phage T4 107.0 -2.89 yes 48.66 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 17.739999961853027, 19.56800022125244 in pocket 8218201 10.1021/bi00093a013 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7591 236 164 A130S Endolysin Enterobacteria phage T4 1.0 yes Potassium phosphate 20 mM 51.55 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 17.739999961853027, 19.56800022125244 in pocket 8218201 10.1021/bi00093a013 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 10026 4336 164 A130G Endolysin Enterobacteria phage T4 2.1 12.8 2.6 Unknown Potassium phosphate 20 mM 25.0 NaCl 100 mM CD Urea 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 17.739999961853027, 19.56800022125244 in pocket 17400925 10.1110/ps.062632807 2007 ProTherm SAAFEC_S1262.csv 583 334 164 V131A Endolysin Enterobacteria phage T4 2.4 88.7 1.0 yes 41.25 Unknown KCl 0.2 M CD Thermal 2.02 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 22.488571166992188, 16.635714530944824 in pocket 1304917 10.1002/pro.5560010608 1992 ProTherm M47andM8_S2760.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 903 334 164 V131A Endolysin Enterobacteria phage T4 1.8 123.0 0.72 Unknown 54.14 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 22.488571166992188, 16.635714530944824 in pocket 8771182 10.1093/protein/8.10.1017 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 910 334 164 V131A Endolysin Enterobacteria phage T4 2.5 140.0 0.87 Unknown 67.38 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 22.488571166992188, 16.635714530944824 in pocket 8771182 10.1093/protein/8.10.1017 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 949 334 164 V131A Endolysin Enterobacteria phage T4 128.0 0.66 yes 53.74 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 22.488571166992188, 16.635714530944824 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 993 334 164 V131A Endolysin Enterobacteria phage T4 84.8 0.56 Unknown 42.03 Unknown KCl 0.2 M CD Thermal 2.03 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 22.488571166992188, 16.635714530944824 in pocket 2326253 10.1002/prot.340070208 1990 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 996 334 164 V131A Endolysin Enterobacteria phage T4 106.3 0.9 Unknown 52.0 Unknown KCl 0.2 M CD Thermal 2.83 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 22.488571166992188, 16.635714530944824 in pocket 2326253 10.1002/prot.340070208 1990 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3499 334 164 V131A Endolysin Enterobacteria phage T4 88.7 1.0 yes 41.8 HCl KCl 0.20 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 22.488571166992188, 16.635714530944824 in pocket 1998663 10.1021/bi00222a001 1991 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6725 334 164 V131A Endolysin Enterobacteria phage T4 2.5 -0.39 Unknown Acetic acid, Sodium acetate 1.4 mM, 8.6 mM 66.51 NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 22.488571166992188, 16.635714530944824 in pocket 8771182 10.1093/protein/8.10.1017 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, potapov_with_uniprot_mapping.csv 7340 334 164 V131A Endolysin Enterobacteria phage T4 1.8 -0.33 Unknown KH2PO4, H3PO4 17 mM, 3 mM 53.42 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 22.488571166992188, 16.635714530944824 in pocket 8771182 10.1093/protein/8.10.1017 1995 ProTherm capriotti_S1615_map.csv 7387 334 164 V131A Endolysin Enterobacteria phage T4 2.4 -0.26 yes KH2PO4, H3PO4 17 mM, 3 mM 53.08 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 22.488571166992188, 16.635714530944824 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm capriotti_S1615_map.csv 7611 334 164 V131A Endolysin Enterobacteria phage T4 -0.3 Unknown K2HPO4, NaH2PO4 1.05 M, 1.26 M 51.1 KCl 0.2 M CD Thermal 2.83 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 22.488571166992188, 16.635714530944824 in pocket 2326253 10.1002/prot.340070208 1990 ProTherm capriotti_S1615_map.csv 8052 334 164 V131A Endolysin Enterobacteria phage T4 -0.15 Unknown K2HPO4, NaH2PO4 1.05 M, 1.26 M 41.47 KCl 0.2 M CD Thermal 2.03 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 22.488571166992188, 16.635714530944824 in pocket 2326253 10.1002/prot.340070208 1990 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 8069 334 164 V131A Endolysin Enterobacteria phage T4 -0.26 yes HCl 40.8 KCl 0.20 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 22.488571166992188, 16.635714530944824 in pocket 1998663 10.1021/bi00222a001 1991 ProTherm capriotti_S1615_map.csv 8071 334 164 V131A Endolysin Enterobacteria phage T4 2.4 -0.27 yes Unknown 40.75 KCl 0.2 M CD Thermal 2.02 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 22.488571166992188, 16.635714530944824 in pocket 1304917 10.1002/pro.5560010608 1992 ProTherm capriotti_S1615_map.csv 950 565 164 V131L Endolysin Enterobacteria phage T4 121.0 0.23 yes 53.31 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 22.488571166992188, 16.635714530944824 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7388 565 164 V131L Endolysin Enterobacteria phage T4 2.4 -0.09 yes KH2PO4, H3PO4 17 mM, 3 mM 53.08 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 22.488571166992188, 16.635714530944824 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 951 566 164 V131M Endolysin Enterobacteria phage T4 126.0 0.32 yes 53.4 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 22.488571166992188, 16.635714530944824 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7389 566 164 V131M Endolysin Enterobacteria phage T4 2.4 -0.12 yes KH2PO4, H3PO4 17 mM, 3 mM 53.08 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 22.488571166992188, 16.635714530944824 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 952 567 164 V131I Endolysin Enterobacteria phage T4 127.0 0.41 yes 53.49 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 22.488571166992188, 16.635714530944824 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7390 567 164 V131I Endolysin Enterobacteria phage T4 2.4 -0.16 yes KH2PO4, H3PO4 17 mM, 3 mM 53.08 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 22.488571166992188, 16.635714530944824 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 953 568 164 V131T Endolysin Enterobacteria phage T4 122.0 -0.33 yes 52.75 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 22.488571166992188, 16.635714530944824 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 994 568 164 V131T Endolysin Enterobacteria phage T4 82.4 -0.41 Unknown 41.06 Unknown KCl 0.2 M CD Thermal 2.03 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 22.488571166992188, 16.635714530944824 in pocket 2326253 10.1002/prot.340070208 1990 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 997 568 164 V131T Endolysin Enterobacteria phage T4 106.3 -0.1 Unknown 50.95 Unknown KCl 0.2 M CD Thermal 2.83 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 22.488571166992188, 16.635714530944824 in pocket 2326253 10.1002/prot.340070208 1990 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7391 568 164 V131T Endolysin Enterobacteria phage T4 2.4 0.12 yes KH2PO4, H3PO4 17 mM, 3 mM 53.08 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 22.488571166992188, 16.635714530944824 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, potapov_with_uniprot_mapping.csv 7612 568 164 V131T Endolysin Enterobacteria phage T4 0.05 Unknown K2HPO4, NaH2PO4 1.05 M, 1.26 M 51.1 KCl 0.2 M CD Thermal 2.83 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 22.488571166992188, 16.635714530944824 in pocket 2326253 10.1002/prot.340070208 1990 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 8053 568 164 V131T Endolysin Enterobacteria phage T4 0.11 Unknown K2HPO4, NaH2PO4 1.05 M, 1.26 M 41.47 KCl 0.2 M CD Thermal 2.03 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 22.488571166992188, 16.635714530944824 in pocket 2326253 10.1002/prot.340070208 1990 ProTherm capriotti_S1615_map.csv 954 569 164 V131E Endolysin Enterobacteria phage T4 128.0 0.52 yes 53.6 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 22.488571166992188, 16.635714530944824 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7392 569 164 V131E Endolysin Enterobacteria phage T4 2.4 -0.2 yes KH2PO4, H3PO4 17 mM, 3 mM 53.08 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 22.488571166992188, 16.635714530944824 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 955 570 164 V131S Endolysin Enterobacteria phage T4 124.0 -0.12 yes 52.96 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 22.488571166992188, 16.635714530944824 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7393 570 164 V131S Endolysin Enterobacteria phage T4 2.4 0.05 yes KH2PO4, H3PO4 17 mM, 3 mM 53.08 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 22.488571166992188, 16.635714530944824 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 956 571 164 V131D Endolysin Enterobacteria phage T4 123.0 0.22 yes 53.3 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 22.488571166992188, 16.635714530944824 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7394 571 164 V131D Endolysin Enterobacteria phage T4 2.4 -0.08 yes KH2PO4, H3PO4 17 mM, 3 mM 53.08 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 22.488571166992188, 16.635714530944824 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 957 572 164 V131G Endolysin Enterobacteria phage T4 123.0 -1.8 yes 51.28 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 22.488571166992188, 16.635714530944824 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7395 572 164 V131G Endolysin Enterobacteria phage T4 2.4 0.68 yes KH2PO4, H3PO4 17 mM, 3 mM 53.08 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 2.0 1L63, 2LZM 22.488571166992188, 16.635714530944824 in pocket 8289284 10.1006/jmbi.1994.1016 1994 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14519 6747 164 V131A, N132A Endolysin Enterobacteria phage T4 2.4 82.0 2.3 yes 43.05 Unknown KCl 0.2 M CD Thermal 2.02 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 2.0, 6.0 1L63, 2LZM 22.488571166992188, 18.553750157356262, 16.635714530944824, 16.804999947547913 in pocket 1304917 10.1002/pro.5560010608 1992 ProTherm 14719 6747 164 V131A, N132A Endolysin Enterobacteria phage T4 82.0 2.3 yes 43.1 HCl KCl 0.20 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 2.0, 6.0 1L63, 2LZM 22.488571166992188, 18.553750157356262, 16.635714530944824, 16.804999947547913 in pocket 1998663 10.1021/bi00222a001 1991 ProTherm 15100 6747 164 V131A, N132A Endolysin Enterobacteria phage T4 -0.62 yes HCl 40.8 KCl 0.20 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 2.0, 6.0 1L63, 2LZM 22.488571166992188, 18.553750157356262, 16.635714530944824, 16.804999947547913 in pocket 1998663 10.1021/bi00222a001 1991 ProTherm 15104 6747 164 V131A, N132A Endolysin Enterobacteria phage T4 2.4 -0.57 yes Unknown 40.75 KCl 0.2 M CD Thermal 2.02 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 2.0, 6.0 1L63, 2LZM 22.488571166992188, 18.553750157356262, 16.635714530944824, 16.804999947547913 in pocket 1304917 10.1002/pro.5560010608 1992 ProTherm 921 538 164 N132M Endolysin Enterobacteria phage T4 3.5 134.0 3.6 yes 70.08 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 6.0 1L63, 2LZM 18.553750157356262, 16.804999947547913 in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6736 538 164 N132M Endolysin Enterobacteria phage T4 3.5 -1.5 yes Acetic acid, Sodium acetate 1.4 mM, 8.6 mM 66.48 NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 6.0 1L63, 2LZM 18.553750157356262, 16.804999947547913 in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 922 539 164 N132F Endolysin Enterobacteria phage T4 3.5 134.0 3.3 yes 69.78 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 6.0 1L63, 2LZM 18.553750157356262, 16.804999947547913 in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6737 539 164 N132F Endolysin Enterobacteria phage T4 3.5 -1.3 yes Acetic acid, Sodium acetate 1.4 mM, 8.6 mM 66.48 NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 6.0 1L63, 2LZM 18.553750157356262, 16.804999947547913 in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 923 540 164 N132I Endolysin Enterobacteria phage T4 3.5 140.0 3.0 yes 69.48 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 6.0 1L63, 2LZM 18.553750157356262, 16.804999947547913 in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6738 540 164 N132I Endolysin Enterobacteria phage T4 3.5 -1.2 yes Acetic acid, Sodium acetate 1.4 mM, 8.6 mM 66.48 NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme binding site 6.0 1L63, 2LZM 18.553750157356262, 16.804999947547913 in pocket 7831309 10.1073/pnas.92.2.452 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 42 42 164 L133A Endolysin Enterobacteria phage T4 2.5 91.5 -8.9 yes 42.9 Potassium phosphate 0.020 M KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 17.339999794960022, 14.184999942779541 in pocket 1553543 10.1126/science.1553543 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 584 42 164 L133A Endolysin Enterobacteria phage T4 2.4 53.0 -17.0 yes 23.75 Unknown KCl 0.2 M CD Thermal 2.02 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 17.339999794960022, 14.184999942779541 in pocket 1304917 10.1002/pro.5560010608 1992 ProTherm M47andM8_S2760.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7503 42 164 L133A Endolysin Enterobacteria phage T4 2.5 4.3 yes Potassium phosphate 0.020 M 51.8 KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 17.339999794960022, 14.184999942779541 in pocket 1553543 10.1126/science.1553543 1992 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, potapov_with_uniprot_mapping.csv 8072 42 164 L133A Endolysin Enterobacteria phage T4 2.4 4.19 yes Unknown 40.75 KCl 0.2 M CD Thermal 2.02 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 17.339999794960022, 14.184999942779541 in pocket 1304917 10.1002/pro.5560010608 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 305 168 164 L133M Endolysin Enterobacteria phage T4 2.5 128.0 -1.0 Unknown 64.3 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 0.1 M CD Thermal 5.42 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 17.339999794960022, 14.184999942779541 in pocket 8901549 10.1073/pnas.93.22.12155 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6776 168 164 L133M Endolysin Enterobacteria phage T4 2.5 0.4 Unknown Acetic acid,Sodium acetate 1.4 mM,8.6 mM 65.3 NaCl 0.1 M CD Thermal 5.42 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 17.339999794960022, 14.184999942779541 in pocket 8901549 10.1073/pnas.93.22.12155 1996 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 596 340 164 L133D Endolysin Enterobacteria phage T4 1.8 47.9 -14.9 yes 36.7 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 17.339999794960022, 14.184999942779541 in pocket 1747370 10.1021/bi00113a006 1991 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 597 340 164 L133D Endolysin Enterobacteria phage T4 1.8 59.1 -15.0 yes 49.6 Potassium phosphate 20 mM KCl 25 mM CD Thermal 4.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 17.339999794960022, 14.184999942779541 in pocket 1747370 10.1021/bi00113a006 1991 ProTherm STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 599 340 164 L133D Endolysin Enterobacteria phage T4 1.8 50.8 -17.9 yes(50-75%) 44.0 Potassium phosphate 20 mM KCl 25 mM CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 17.339999794960022, 14.184999942779541 in pocket 1747370 10.1021/bi00113a006 1991 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 601 340 164 L133D Endolysin Enterobacteria phage T4 1.8 47.1 -19.0 yes(20%) 28.9 Potassium phosphate 20 mM KCl 25 mM CD Thermal 10.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 17.339999794960022, 14.184999942779541 in pocket 1747370 10.1021/bi00113a006 1991 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7005 340 164 L133D Endolysin Enterobacteria phage T4 1.8 5.5 yes Potassium phosphate 20 mM 64.6 KCl 25 mM CD Thermal 4.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 17.339999794960022, 14.184999942779541 in pocket 1747370 10.1021/bi00113a006 1991 ProTherm capriotti_S1615_map.csv 7075 340 164 L133D Endolysin Enterobacteria phage T4 1.8 5.7 yes(50-75%) Potassium phosphate 20 mM 61.9 KCl 25 mM CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 17.339999794960022, 14.184999942779541 in pocket 1747370 10.1021/bi00113a006 1991 ProTherm capriotti_S1615_map.csv 7581 340 164 L133D Endolysin Enterobacteria phage T4 1.8 4.9 yes Potassium phosphate 20 mM 51.6 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 17.339999794960022, 14.184999942779541 in pocket 1747370 10.1021/bi00113a006 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 707 434 164 L133F Endolysin Enterobacteria phage T4 83.0 -0.7 yes 40.7 Unknown KCl 0.2 M CD Thermal 1.99 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 17.339999794960022, 14.184999942779541 in pocket 2682639 10.1073/pnas.86.21.8237 1989 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 709 434 164 L133F Endolysin Enterobacteria phage T4 -0.8 yes 51.3 Unknown KCl 0.2 M CD Thermal 2.86 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 17.339999794960022, 14.184999942779541 in pocket 2682639 10.1073/pnas.86.21.8237 1989 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 1429 434 164 L133F Endolysin Enterobacteria phage T4 130.0 -0.7 Unknown 64.8 sodium chloride, acetic acid, sodium acetate 0.10 M, 1.4 mM, 8.6 mM CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 17.339999794960022, 14.184999942779541 in pocket 12963380 10.1016/s0022-2836(03)00856-8 2003 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7085 434 164 L133F Endolysin Enterobacteria phage T4 2.5 0.3 Unknown sodium chloride, acetic acid, sodium acetate 0.10 M, 1.4 mM, 8.6 mM 61.0 CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 17.339999794960022, 14.184999942779541 in pocket 12963380 10.1016/s0022-2836(03)00856-8 2003 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 7462 434 164 L133F Endolysin Enterobacteria phage T4 0.3 yes Unknown 52.1 KCl 0.2 M CD Thermal 2.86 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 17.339999794960022, 14.184999942779541 in pocket 2682639 10.1073/pnas.86.21.8237 1989 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 8055 434 164 L133F Endolysin Enterobacteria phage T4 0.2 yes Unknown 41.4 KCl 0.2 M CD Thermal 1.99 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 17.339999794960022, 14.184999942779541 in pocket 2682639 10.1073/pnas.86.21.8237 1989 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 423 237 164 A134S Endolysin Enterobacteria phage T4 111.0 -0.44 yes 51.11 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 16.299999809265138, 18.686000251770018 in pocket 8218201 10.1021/bi00093a013 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7592 237 164 A134S Endolysin Enterobacteria phage T4 0.1 yes Potassium phosphate 20 mM 51.55 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 16.299999809265138, 18.686000251770018 in pocket 8218201 10.1021/bi00093a013 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 71 57 164 K135E Endolysin Enterobacteria phage T4 -0.7 yes 50.2 Potassium phosphate 20 mM KCl 25 mM CD Thermal 2.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 32.19444444444444, 28.960000144110786 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm HotMuSiC_S1626.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 76 57 164 K135E Endolysin Enterobacteria phage T4 -2.3 yes 64.4 Potassium phosphate 20 mM KCl 25 mM CD Thermal 5.3 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 32.19444444444444, 28.960000144110786 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6712 57 164 K135E Endolysin Enterobacteria phage T4 1.0 yes Potassium phosphate 20 mM 66.7 KCl 25 mM CD Thermal 5.3 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 32.19444444444444, 28.960000144110786 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm capriotti_S1615_map.csv 7616 57 164 K135E Endolysin Enterobacteria phage T4 0.2 yes Potassium phosphate 20 mM 50.9 KCl 25 mM CD Thermal 2.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 32.19444444444444, 28.960000144110786 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 11154 57 164 K135E Endolysin Enterobacteria phage T4 1.0 Unknown Potassium phosphate 20 mM 25.0 KCl 25 mM CD Thermal 5.3 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 32.19444444444444, 28.960000144110786 in pocket 10933506 10.1110/ps.9.7.1395 2000 ProTherm capriotti_S1615_map.csv 3627 1882 164 K135C Endolysin Enterobacteria phage T4 -2.6 yes 33.8 Potassium phosphate 20 mM KCl 25 mM CD Thermal 2.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 32.19444444444444, 28.960000144110786 in pocket 1510962 10.1021/bi00149a004 1992 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, Broom_S605.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 14445 6704 164 K135E, K147E Endolysin Enterobacteria phage T4 -0.9 yes 50.0 Potassium phosphate 20 mM KCl 25 mM CD Thermal 2.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0, 3.0 1L63, 2LZM 32.19444444444444, 33.90444416469998, 28.960000144110786, 28.260000122918022 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm 14453 6704 164 K135E, K147E Endolysin Enterobacteria phage T4 -3.7 yes 63.0 Potassium phosphate 20 mM KCl 25 mM CD Thermal 5.3 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0, 3.0 1L63, 2LZM 32.19444444444444, 33.90444416469998, 28.960000144110786, 28.260000122918022 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm 14890 6704 164 K135E, K147E Endolysin Enterobacteria phage T4 1.5 yes Potassium phosphate 20 mM 66.7 KCl 25 mM CD Thermal 5.3 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0, 3.0 1L63, 2LZM 32.19444444444444, 33.90444416469998, 28.960000144110786, 28.260000122918022 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm 15037 6704 164 K135E, K147E Endolysin Enterobacteria phage T4 0.3 yes Potassium phosphate 20 mM 50.9 KCl 25 mM CD Thermal 2.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0, 3.0 1L63, 2LZM 32.19444444444444, 33.90444416469998, 28.960000144110786, 28.260000122918022 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm 244 132 164 W138Y Endolysin Enterobacteria phage T4 2.1 104.0 Unknown 46.85 Unknown CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 16.036428587777273, 14.857142925262451 in tunnel in pocket 7306671 10.1002/bip.1981.360200921 1981 ProTherm 249 132 164 W138Y Endolysin Enterobacteria phage T4 2.1 -3.0 Unknown 34.0 Unknown CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 16.036428587777273, 14.857142925262451 in tunnel in pocket 7306671 10.1002/bip.1981.360200921 1981 ProTherm EASE-MM_S1676.csv, HotMuSiC_S1626.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 572 132 164 W138Y Endolysin Enterobacteria phage T4 83.8 -6.3 yes 36.3 Sodium phosphate 0.2 M NaCl 0.5 M CD Thermal 2.2 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 16.036428587777273, 14.857142925262451 in tunnel in pocket 911878 10.1016/0005-2795(77)90166-0 1977 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 573 132 164 W138Y Endolysin Enterobacteria phage T4 1.71 83.8 -6.3 yes 36.3 Sodium phosphate 0.2 M NaCl 0.5 M CD Thermal 2.2 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 16.036428587777273, 14.857142925262451 in tunnel in pocket 911878 10.1016/0005-2795(77)90166-0 1977 ProTherm khan_protherm_data_mapped.csv, M47andM8_S2760.csv, potapov_with_uniprot_mapping.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 12618 132 164 W138Y Endolysin Enterobacteria phage T4 4.9 2.87 Unknown imidazole,MOPS, 0.05 M,0.05 M, 22.0 Gel electrophoresis Urea 7.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 16.036428587777273, 14.857142925262451 in tunnel in pocket 1988046 10.1021/bi00216a038 1991 ProTherm SAAFEC_S1262.csv 3621 1877 164 T142C Endolysin Enterobacteria phage T4 -0.5 yes 35.9 Potassium phosphate 20 mM KCl 25 mM CD Thermal 2.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 16.76714297703334, 13.06571442740304 in tunnel in pocket 1510962 10.1021/bi00149a004 1992 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 2999 1600 164 P143A Endolysin Enterobacteria phage T4 -5.0 yes 36.9 phosphate 50 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 18.821428843906947, 14.97000013078962 7074100 10.1021/bi00535a054 1982 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4656 1600 164 P143A Endolysin Enterobacteria phage T4 -5.0 yes 2.0 36.9 Phosphate buffer 50 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 18.821428843906947, 14.97000013078962 1737005 10.1021/bi00120a025 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 13901 1600 164 P143A Endolysin Enterobacteria phage T4 3.01 17.2 yes 2.0 Phosphate buffer 50 mM 12.0 CD GdnHCl 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 18.821428843906947, 14.97000013078962 1737005 10.1021/bi00120a025 1992 ProTherm 822 507 164 N144H Endolysin Enterobacteria phage T4 -2.3 yes 37.2 HCl 0.01 N KCl 200 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 21.59874975681305, 17.32000035047531 1911773 10.1021/bi00105a002 1991 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 827 507 164 N144H Endolysin Enterobacteria phage T4 0.7 yes 63.1 HCl 0.01 N KCl 200 mM CD Thermal 6.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 21.59874975681305, 17.32000035047531 1911773 10.1021/bi00105a002 1991 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7066 507 164 N144H Endolysin Enterobacteria phage T4 -0.3 yes HCl 0.01 N 62.4 KCl 200 mM CD Thermal 6.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 21.59874975681305, 17.32000035047531 1911773 10.1021/bi00105a002 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 8161 507 164 N144H Endolysin Enterobacteria phage T4 0.6 yes HCl 0.01 N 39.5 KCl 200 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 21.59874975681305, 17.32000035047531 1911773 10.1021/bi00105a002 1991 ProTherm capriotti_S1615_map.csv 901 528 164 N144D Endolysin Enterobacteria phage T4 1.8 125.0 0.94 Unknown 54.36 KH2PO4,H3PO4, 17 mM,3 mM, KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 21.59874975681305, 17.32000035047531 8771182 10.1093/protein/8.10.1017 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 908 528 164 N144D Endolysin Enterobacteria phage T4 2.5 142.0 0.99 Unknown 67.5 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 21.59874975681305, 17.32000035047531 8771182 10.1093/protein/8.10.1017 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3298 528 164 N144D Endolysin Enterobacteria phage T4 -0.2 yes 40.7 HCl 0.01 N KCl 200 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 21.59874975681305, 17.32000035047531 1911773 10.1021/bi00105a002 1991 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3303 528 164 N144D Endolysin Enterobacteria phage T4 1.4 yes 67.5 phosphate 10 mM KCl 150 mM CD Thermal 6.9 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 21.59874975681305, 17.32000035047531 1911773 10.1021/bi00105a002 1991 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6723 528 164 N144D Endolysin Enterobacteria phage T4 2.5 -0.41 Unknown Acetic acid, Sodium acetate 1.4 mM, 8.6 mM 66.51 NaCl 100 mM CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 21.59874975681305, 17.32000035047531 8771182 10.1093/protein/8.10.1017 1995 ProTherm capriotti_S1615_map.csv 6753 528 164 N144D Endolysin Enterobacteria phage T4 -0.5 yes phosphate 10 mM 66.1 KCl 150 mM CD Thermal 6.9 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 21.59874975681305, 17.32000035047531 1911773 10.1021/bi00105a002 1991 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, potapov_with_uniprot_mapping.csv 7338 528 164 N144D Endolysin Enterobacteria phage T4 1.8 -0.4 Unknown KH2PO4, H3PO4 17 mM, 3 mM 53.42 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 21.59874975681305, 17.32000035047531 8771182 10.1093/protein/8.10.1017 1995 ProTherm capriotti_S1615_map.csv 8067 528 164 N144D Endolysin Enterobacteria phage T4 0.1 yes HCl 0.01 N 40.9 KCl 200 mM CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 21.59874975681305, 17.32000035047531 1911773 10.1021/bi00105a002 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 3410 1774 164 N144E Endolysin Enterobacteria phage T4 83.0 0.9 yes 39.4 HCl 10 mM KCl 0.15 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 21.59874975681305, 17.32000035047531 1854726 10.1021/bi00243a015 1991 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3411 1774 164 N144E Endolysin Enterobacteria phage T4 136.0 1.4 yes 66.8 acetate 10 mM KCl 0.15 M CD Thermal 5.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 21.59874975681305, 17.32000035047531 1854726 10.1021/bi00243a015 1991 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3412 1774 164 N144E Endolysin Enterobacteria phage T4 138.0 1.5 yes 64.5 Potassium phosphate 10 mM KCl 0.15 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 21.59874975681305, 17.32000035047531 1854726 10.1021/bi00243a015 1991 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6717 1774 164 N144E Endolysin Enterobacteria phage T4 -0.5 yes acetate 10 mM 66.7 KCl 0.15 M CD Thermal 5.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 21.59874975681305, 17.32000035047531 1854726 10.1021/bi00243a015 1991 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 7022 1774 164 N144E Endolysin Enterobacteria phage T4 -0.5 yes Potassium phosphate 10 mM 64.5 KCl 0.15 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 21.59874975681305, 17.32000035047531 1854726 10.1021/bi00243a015 1991 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 8080 1774 164 N144E Endolysin Enterobacteria phage T4 -0.2 yes HCl 10 mM 40.4 KCl 0.15 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 21.59874975681305, 17.32000035047531 1854726 10.1021/bi00243a015 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 14548 6769 164 N144E, K147M Endolysin Enterobacteria phage T4 86.0 1.1 yes 39.6 HCl 10 mM KCl 0.15 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0, 3.0 1L63, 2LZM 21.59874975681305, 33.90444416469998, 17.32000035047531, 28.260000122918022 in pocket 1854726 10.1021/bi00243a015 1991 ProTherm 14549 6769 164 N144E, K147M Endolysin Enterobacteria phage T4 139.0 1.2 yes 66.6 HCl 10 mM KCl 0.15 M CD Thermal 5.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0, 3.0 1L63, 2LZM 21.59874975681305, 33.90444416469998, 17.32000035047531, 28.260000122918022 in pocket 1854726 10.1021/bi00243a015 1991 ProTherm 14550 6769 164 N144E, K147M Endolysin Enterobacteria phage T4 134.0 1.2 yes 64.2 HCl 10 mM KCl 0.15 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0, 3.0 1L63, 2LZM 21.59874975681305, 33.90444416469998, 17.32000035047531, 28.260000122918022 in pocket 1854726 10.1021/bi00243a015 1991 ProTherm 14907 6769 164 N144E, K147M Endolysin Enterobacteria phage T4 -0.5 yes HCl 10 mM 65.4 KCl 0.15 M CD Thermal 5.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0, 3.0 1L63, 2LZM 21.59874975681305, 33.90444416469998, 17.32000035047531, 28.260000122918022 in pocket 1854726 10.1021/bi00243a015 1991 ProTherm 14936 6769 164 N144E, K147M Endolysin Enterobacteria phage T4 -0.4 yes HCl 10 mM 63.0 KCl 0.15 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0, 3.0 1L63, 2LZM 21.59874975681305, 33.90444416469998, 17.32000035047531, 28.260000122918022 in pocket 1854726 10.1021/bi00243a015 1991 ProTherm 15143 6769 164 N144E, K147M Endolysin Enterobacteria phage T4 -0.3 yes HCl 10 mM 28.5 KCl 0.15 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0, 3.0 1L63, 2LZM 21.59874975681305, 33.90444416469998, 17.32000035047531, 28.260000122918022 in pocket 1854726 10.1021/bi00243a015 1991 ProTherm 248 135 164 A146T Endolysin Enterobacteria phage T4 2.5 56.8 Unknown 46.85 Unknown CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.489999771118164, 15.284000205993653 7306671 10.1002/bip.1981.360200921 1981 ProTherm 253 135 164 A146T Endolysin Enterobacteria phage T4 2.5 -9.0 Unknown 50.0 Unknown CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.489999771118164, 15.284000205993653 7306671 10.1002/bip.1981.360200921 1981 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 480 135 164 A146T Endolysin Enterobacteria phage T4 -9.4 yes 47.4 Unknown NaCl 0.2 M CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.489999771118164, 15.284000205993653 6726809 10.1016/0022-2836(84)90474-1 1984 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 623 135 164 A146T Endolysin Enterobacteria phage T4 -9.0 yes 42.6 HCl CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.489999771118164, 15.284000205993653 3323816 10.1016/0076-6879(87)54093-9 1987 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 817 135 164 A146T Endolysin Enterobacteria phage T4 -6.0 yes 59.0 Unknown KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.489999771118164, 15.284000205993653 3277175 10.1073/pnas.85.2.401 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6645 135 164 A146T Endolysin Enterobacteria phage T4 1.5 yes Unknown 70.0 KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.489999771118164, 15.284000205993653 3277175 10.1073/pnas.85.2.401 1988 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 7797 135 164 A146T Endolysin Enterobacteria phage T4 2.29 0.06 yes Unknown 47.0 NaCl 0.2 M CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.489999771118164, 15.284000205993653 6726809 10.1016/0022-2836(84)90474-1 1984 ProTherm capriotti_S1615_map.csv 12620 135 164 A146T Endolysin Enterobacteria phage T4 4.9 2.87 Unknown imidazole,MOPS, 0.05 M,0.05 M, 22.0 Gel electrophoresis Urea 7.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.489999771118164, 15.284000205993653 1988046 10.1021/bi00216a038 1991 ProTherm SAAFEC_S1262.csv 3620 1876 164 A146C Endolysin Enterobacteria phage T4 -4.1 yes 32.3 Potassium phosphate 20 mM KCl 25 mM CD Thermal 2.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.489999771118164, 15.284000205993653 1510962 10.1021/bi00149a004 1992 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3628 1876 164 A146C Endolysin Enterobacteria phage T4 yes 58.3 Potassium acetate 100 mM CD Thermal 5.3 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.489999771118164, 15.284000205993653 1510962 10.1021/bi00149a004 1992 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 12619 5836 164 A146I Endolysin Enterobacteria phage T4 4.2 4.31 Unknown imidazole,MOPS, 0.05 M,0.05 M, 22.0 Gel electrophoresis Urea 7.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.489999771118164, 15.284000205993653 1988046 10.1021/bi00216a038 1991 ProTherm SAAFEC_S1262.csv 12621 5837 164 A146V Endolysin Enterobacteria phage T4 4.1 4.31 Unknown imidazole,MOPS, 0.05 M,0.05 M, 22.0 Gel electrophoresis Urea 7.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 9.0 1L63, 2LZM 17.489999771118164, 15.284000205993653 1988046 10.1021/bi00216a038 1991 ProTherm SAAFEC_S1262.csv 72 58 164 K147E Endolysin Enterobacteria phage T4 0.2 yes 51.1 Potassium phosphate 20 mM KCl 25 mM CD Thermal 2.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 33.90444416469998, 28.260000122918022 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 77 58 164 K147E Endolysin Enterobacteria phage T4 -1.6 yes 65.1 Potassium phosphate 20 mM KCl 25 mM CD Thermal 5.3 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 33.90444416469998, 28.260000122918022 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6713 58 164 K147E Endolysin Enterobacteria phage T4 0.7 yes Potassium phosphate 20 mM 66.7 KCl 25 mM CD Thermal 5.3 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 33.90444416469998, 28.260000122918022 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm capriotti_S1615_map.csv 7617 58 164 K147E Endolysin Enterobacteria phage T4 -0.1 yes Potassium phosphate 20 mM 50.9 KCl 25 mM CD Thermal 2.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 33.90444416469998, 28.260000122918022 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 11155 58 164 K147E Endolysin Enterobacteria phage T4 0.7 Unknown Potassium phosphate 20 mM 25.0 KCl 25 mM CD Thermal 5.3 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 33.90444416469998, 28.260000122918022 in pocket 10933506 10.1110/ps.9.7.1395 2000 ProTherm capriotti_S1615_map.csv 387 206 164 V149A Endolysin Enterobacteria phage T4 107.0 -8.9 Unknown 56.4 sodium acetate 0.010 M NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.521428653172084, 9.985714299338204 11316887 10.1110/ps.02101 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 2035 206 164 V149A Endolysin Enterobacteria phage T4 106.0 -9.0 Yes(80%) 2.0 56.3 acetic acid, sodium acetate 1.4 mM, 8.6 mM Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.521428653172084, 9.985714299338204 10545167 10.1021/bi9915519 1999 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 3136 206 164 V149A Endolysin Enterobacteria phage T4 1.8 66.0 -11.0 Unknown 40.7 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.521428653172084, 9.985714299338204 9514271 10.1002/pro.5560070117 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6802 206 164 V149A Endolysin Enterobacteria phage T4 3.2 Yes(80%) 2.0 acetic acid, sodium acetate 1.4 mM, 8.6 mM 65.3 Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.521428653172084, 9.985714299338204 10545167 10.1021/bi9915519 1999 ProTherm khan_protherm_data_mapped.csv 7120 206 164 V149A Endolysin Enterobacteria phage T4 3.1 Unknown sodium acetate 0.010 M 59.0 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.521428653172084, 9.985714299338204 11316887 10.1110/ps.02101 2001 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 7570 206 164 V149A Endolysin Enterobacteria phage T4 1.8 3.2 Unknown Potassium phosphate 20 mM 51.65 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.521428653172084, 9.985714299338204 9514271 10.1002/pro.5560070117 1998 ProTherm capriotti_S1615_map.csv 12622 206 164 V149A Endolysin Enterobacteria phage T4 4.9 2.87 Unknown imidazole,MOPS, 0.05 M,0.05 M, 22.0 Gel electrophoresis Urea 7.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.521428653172084, 9.985714299338204 1988046 10.1021/bi00216a038 1991 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 388 207 164 V149S Endolysin Enterobacteria phage T4 94.0 -13.2 Unknown 52.1 sodium acetate 0.010 M NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.521428653172084, 9.985714299338204 11316887 10.1110/ps.02101 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7121 207 164 V149S Endolysin Enterobacteria phage T4 4.4 Unknown sodium acetate 0.010 M 59.0 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.521428653172084, 9.985714299338204 11316887 10.1110/ps.02101 2001 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 389 208 164 V149C Endolysin Enterobacteria phage T4 113.0 -5.5 Unknown 59.8 sodium acetate 0.010 M NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.521428653172084, 9.985714299338204 11316887 10.1110/ps.02101 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 992 208 164 V149C Endolysin Enterobacteria phage T4 109.8 -5.1 yes 49.0 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.521428653172084, 9.985714299338204 1920439 10.1016/0022-2836(91)80079-a 1991 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7122 208 164 V149C Endolysin Enterobacteria phage T4 2.0 Unknown sodium acetate 0.010 M 59.0 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.521428653172084, 9.985714299338204 11316887 10.1110/ps.02101 2001 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8096 208 164 V149C Endolysin Enterobacteria phage T4 2.41 2.2 yes Potassium phosphate 20 mM 40.0 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.521428653172084, 9.985714299338204 1920439 10.1016/0022-2836(91)80079-a 1991 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 390 209 164 V149T Endolysin Enterobacteria phage T4 110.0 -8.3 Unknown 57.0 sodium acetate 0.010 M NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.521428653172084, 9.985714299338204 11316887 10.1110/ps.02101 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 426 209 164 V149T Endolysin Enterobacteria phage T4 77.0 -10.08 yes 41.47 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.521428653172084, 9.985714299338204 8218201 10.1021/bi00093a013 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7123 209 164 V149T Endolysin Enterobacteria phage T4 3.0 Unknown sodium acetate 0.010 M 59.0 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.521428653172084, 9.985714299338204 11316887 10.1110/ps.02101 2001 ProTherm capriotti_S1615_map.csv 7595 209 164 V149T Endolysin Enterobacteria phage T4 2.8 yes Potassium phosphate 20 mM 51.55 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.521428653172084, 9.985714299338204 8218201 10.1021/bi00093a013 1993 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 391 210 164 V149I Endolysin Enterobacteria phage T4 123.0 -0.05 Unknown 65.25 sodium acetate 0.010 M NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.521428653172084, 9.985714299338204 11316887 10.1110/ps.02101 2001 ProTherm khan_protherm_data_mapped.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 1430 210 164 V149I Endolysin Enterobacteria phage T4 128.0 -0.3 Unknown 65.2 sodium chloride, acetic acid, sodium acetate 0.10 M, 1.4 mM, 8.6 mM CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.521428653172084, 9.985714299338204 12963380 10.1016/s0022-2836(03)00856-8 2003 ProTherm khan_protherm_data_mapped.csv 7086 210 164 V149I Endolysin Enterobacteria phage T4 2.5 0.0 Unknown sodium chloride, acetic acid, sodium acetate 0.10 M, 1.4 mM, 8.6 mM 61.0 CD Thermal 5.35 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.521428653172084, 9.985714299338204 12963380 10.1016/s0022-2836(03)00856-8 2003 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 7124 210 164 V149I Endolysin Enterobacteria phage T4 0.1 Unknown sodium acetate 0.010 M 59.0 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.521428653172084, 9.985714299338204 11316887 10.1110/ps.02101 2001 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 392 211 164 V149G Endolysin Enterobacteria phage T4 85.0 -15.3 Unknown 50.0 sodium acetate 0.010 M NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.521428653172084, 9.985714299338204 11316887 10.1110/ps.02101 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7125 211 164 V149G Endolysin Enterobacteria phage T4 4.9 Unknown sodium acetate 0.010 M 59.0 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.521428653172084, 9.985714299338204 11316887 10.1110/ps.02101 2001 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 2047 1145 164 V149M Endolysin Enterobacteria phage T4 111.0 -7.8 Yes(80%) 2.0 57.5 acetic acid, sodium acetate 1.4 mM, 8.6 mM Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.521428653172084, 9.985714299338204 10545167 10.1021/bi9915519 1999 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 6814 1145 164 V149M Endolysin Enterobacteria phage T4 2.8 Yes(80%) 2.0 acetic acid, sodium acetate 1.4 mM, 8.6 mM 65.3 Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 15.521428653172084, 9.985714299338204 10545167 10.1021/bi9915519 1999 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 10027 4337 164 I150V Endolysin Enterobacteria phage T4 2.1 12.8 2.5 Unknown Potassium phosphate 20 mM 25.0 NaCl 100 mM CD Urea 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 16.21000027656555, 15.111250042915344 in pocket 17400925 10.1110/ps.062632807 2007 ProTherm SAAFEC_S1262.csv 198 104 164 T151S Endolysin Enterobacteria phage T4 3.5 141.0 0.93 Unknown 66.08 Sodium acetate 10 mM NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 19.020000185285294, 14.727142878941127 in pocket 7507755 10.1002/pro.5560021221 1993 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 210 104 164 T151S Endolysin Enterobacteria phage T4 3.5 0.97 Unknown 63.16 Potassium phosphate 0.01 M KCl 0.15 M CD Thermal 6.78 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 19.020000185285294, 14.727142878941127 in pocket 7507755 10.1002/pro.5560021221 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 1229 104 164 T151S Endolysin Enterobacteria phage T4 0.93 yes 66.03 Sodium acetate 10 mM NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 19.020000185285294, 14.727142878941127 in pocket 8298466 10.1002/pro.5560021222 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6827 104 164 T151S Endolysin Enterobacteria phage T4 3.5 -0.39 Unknown Sodium acetate 10 mM 65.15 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 19.020000185285294, 14.727142878941127 in pocket 7507755 10.1002/pro.5560021221 1993 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 393 212 164 T152A Endolysin Enterobacteria phage T4 115.0 -4.0 Unknown 61.3 sodium acetate 0.010 M NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.934285708836146, 14.574285643441337 11316887 10.1110/ps.02101 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7126 212 164 T152A Endolysin Enterobacteria phage T4 1.5 Unknown sodium acetate 0.010 M 59.0 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.934285708836146, 14.574285643441337 11316887 10.1110/ps.02101 2001 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 394 213 164 T152S Endolysin Enterobacteria phage T4 117.0 -5.5 Unknown 59.8 sodium acetate 0.010 M NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.934285708836146, 14.574285643441337 11316887 10.1110/ps.02101 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 991 213 164 T152S Endolysin Enterobacteria phage T4 106.6 -6.6 yes 47.5 Potassium phosphate 20 mM KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.934285708836146, 14.574285643441337 1920439 10.1016/0022-2836(91)80079-a 1991 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7127 213 164 T152S Endolysin Enterobacteria phage T4 2.0 Unknown sodium acetate 0.010 M 59.0 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.934285708836146, 14.574285643441337 11316887 10.1110/ps.02101 2001 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 8095 213 164 T152S Endolysin Enterobacteria phage T4 2.41 2.6 yes Potassium phosphate 20 mM 40.0 KCl 25 mM CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.934285708836146, 14.574285643441337 1920439 10.1016/0022-2836(91)80079-a 1991 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, potapov_with_uniprot_mapping.csv 395 214 164 T152C Endolysin Enterobacteria phage T4 127.0 -1.4 Unknown 63.9 sodium acetate 0.010 M NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.934285708836146, 14.574285643441337 11316887 10.1110/ps.02101 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7128 214 164 T152C Endolysin Enterobacteria phage T4 0.5 Unknown sodium acetate 0.010 M 59.0 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.934285708836146, 14.574285643441337 11316887 10.1110/ps.02101 2001 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 396 215 164 T152V Endolysin Enterobacteria phage T4 127.0 0.8 Unknown 66.1 sodium acetate 0.010 M NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.934285708836146, 14.574285643441337 11316887 10.1110/ps.02101 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7129 215 164 T152V Endolysin Enterobacteria phage T4 -0.2 Unknown sodium acetate 0.010 M 59.0 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.934285708836146, 14.574285643441337 11316887 10.1110/ps.02101 2001 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 397 216 164 T152I Endolysin Enterobacteria phage T4 125.0 -1.0 Unknown 64.3 sodium acetate 0.010 M NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.934285708836146, 14.574285643441337 11316887 10.1110/ps.02101 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7130 216 164 T152I Endolysin Enterobacteria phage T4 0.4 Unknown sodium acetate 0.010 M 59.0 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 14.934285708836146, 14.574285643441337 11316887 10.1110/ps.02101 2001 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 43 43 164 F153A Endolysin Enterobacteria phage T4 2.5 74.9 -12.3 yes 39.5 Potassium phosphate 0.020 M KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 18.75727298042991, 15.220908858559348 in pocket 1553543 10.1126/science.1553543 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 310 43 164 F153A Endolysin Enterobacteria phage T4 2.5 117.0 -9.3 yes 55.6 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 18.75727298042991, 15.220908858559348 in pocket 8676387 10.1006/jmbi.1996.0338 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 963 43 164 F153A Endolysin Enterobacteria phage T4 75.0 -12.3 yes 39.46 KH2PO4 20 mM KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 18.75727298042991, 15.220908858559348 in pocket 8433369 10.1006/jmbi.1993.1077 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 973 43 164 F153A Endolysin Enterobacteria phage T4 117.0 -9.3 yes 55.58 KH2PO4 10 mM KCl 20 mM CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 18.75727298042991, 15.220908858559348 in pocket 8433369 10.1006/jmbi.1993.1077 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 2036 43 164 F153A Endolysin Enterobacteria phage T4 108.0 -9.7 Yes(80%) 2.0 55.6 acetic acid, sodium acetate 1.4 mM, 8.6 mM Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 18.75727298042991, 15.220908858559348 in pocket 10545167 10.1021/bi9915519 1999 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 6781 43 164 F153A Endolysin Enterobacteria phage T4 2.5 3.4 yes Acetic acid,Sodium acetate 1.4 mM,8.6 mM 65.3 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 18.75727298042991, 15.220908858559348 in pocket 8676387 10.1006/jmbi.1996.0338 1996 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 6803 43 164 F153A Endolysin Enterobacteria phage T4 3.4 Yes(80%) 2.0 acetic acid, sodium acetate 1.4 mM, 8.6 mM 65.3 Sodium Chloride 0.10 M CD, Fluorescence Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 18.75727298042991, 15.220908858559348 in pocket 10545167 10.1021/bi9915519 1999 ProTherm khan_protherm_data_mapped.csv 6976 43 164 F153A Endolysin Enterobacteria phage T4 3.5 3.8 yes KH2PO4 10 mM 64.88 KCl 20 mM CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 18.75727298042991, 15.220908858559348 in pocket 8433369 10.1006/jmbi.1993.1077 1993 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, potapov_with_uniprot_mapping.csv 7504 43 164 F153A Endolysin Enterobacteria phage T4 2.5 3.5 yes Potassium phosphate 0.020 M 51.8 KCl 0.025 M CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 18.75727298042991, 15.220908858559348 in pocket 1553543 10.1126/science.1553543 1992 ProTherm capriotti_S1615_map.csv 7514 43 164 F153A Endolysin Enterobacteria phage T4 2.5 3.5 yes KH2PO4 20 mM 51.76 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 18.75727298042991, 15.220908858559348 in pocket 8433369 10.1006/jmbi.1993.1077 1993 ProTherm capriotti_S1615_map.csv 199 105 164 F153L Endolysin Enterobacteria phage T4 3.5 137.0 0.88 Unknown 66.03 Sodium acetate 10 mM NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 18.75727298042991, 15.220908858559348 in pocket 7507755 10.1002/pro.5560021221 1993 ProTherm AUTOMUTE_S1749.csv, AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, Saraboji_S1791.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 211 105 164 F153L Endolysin Enterobacteria phage T4 3.5 0.51 Unknown 62.7 Potassium phosphate 0.01 M KCl 0.15 M CD Thermal 6.78 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 18.75727298042991, 15.220908858559348 in pocket 7507755 10.1002/pro.5560021221 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 966 105 164 F153L Endolysin Enterobacteria phage T4 115.0 0.6 yes 52.36 KH2PO4 20 mM KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 18.75727298042991, 15.220908858559348 in pocket 8433369 10.1006/jmbi.1993.1077 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 976 105 164 F153L Endolysin Enterobacteria phage T4 135.0 0.8 yes 65.68 KH2PO4 10 mM KCl 20 mM CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 18.75727298042991, 15.220908858559348 in pocket 8433369 10.1006/jmbi.1993.1077 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6828 105 164 F153L Endolysin Enterobacteria phage T4 3.5 -0.35 Unknown Sodium acetate 10 mM 65.15 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 18.75727298042991, 15.220908858559348 in pocket 7507755 10.1002/pro.5560021221 1993 ProTherm capriotti_S1615_map.csv 6979 105 164 F153L Endolysin Enterobacteria phage T4 3.5 -0.3 yes KH2PO4 10 mM 64.88 KCl 20 mM CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 18.75727298042991, 15.220908858559348 in pocket 8433369 10.1006/jmbi.1993.1077 1993 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, potapov_with_uniprot_mapping.csv 7517 105 164 F153L Endolysin Enterobacteria phage T4 2.5 -0.2 yes KH2PO4 20 mM 51.76 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 18.75727298042991, 15.220908858559348 in pocket 8433369 10.1006/jmbi.1993.1077 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 306 169 164 F153M Endolysin Enterobacteria phage T4 2.5 128.0 -1.6 Unknown 63.7 Acetic acid,Sodium acetate, 1.4 mM,8.6 mM, NaCl 0.1 M CD Thermal 5.42 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 18.75727298042991, 15.220908858559348 in pocket 8901549 10.1073/pnas.93.22.12155 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 967 169 164 F153M Endolysin Enterobacteria phage T4 107.0 -2.4 yes 49.36 KH2PO4 20 mM KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 18.75727298042991, 15.220908858559348 in pocket 8433369 10.1006/jmbi.1993.1077 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 977 169 164 F153M Endolysin Enterobacteria phage T4 132.0 -1.6 yes 63.28 KH2PO4 10 mM KCl 20 mM CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 18.75727298042991, 15.220908858559348 in pocket 8433369 10.1006/jmbi.1993.1077 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6777 169 164 F153M Endolysin Enterobacteria phage T4 2.5 0.6 Unknown Acetic acid,Sodium acetate 1.4 mM,8.6 mM 65.3 NaCl 0.1 M CD Thermal 5.42 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 18.75727298042991, 15.220908858559348 in pocket 8901549 10.1073/pnas.93.22.12155 1996 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 6980 169 164 F153M Endolysin Enterobacteria phage T4 3.5 0.6 yes KH2PO4 10 mM 64.88 KCl 20 mM CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 18.75727298042991, 15.220908858559348 in pocket 8433369 10.1006/jmbi.1993.1077 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 7518 169 164 F153M Endolysin Enterobacteria phage T4 2.5 0.8 yes KH2PO4 20 mM 51.76 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 18.75727298042991, 15.220908858559348 in pocket 8433369 10.1006/jmbi.1993.1077 1993 ProTherm capriotti_S1615_map.csv 964 576 164 F153V Endolysin Enterobacteria phage T4 85.0 -6.1 yes 45.66 KH2PO4 20 mM KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 18.75727298042991, 15.220908858559348 in pocket 8433369 10.1006/jmbi.1993.1077 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 974 576 164 F153V Endolysin Enterobacteria phage T4 123.0 -4.5 yes 60.38 KH2PO4 10 mM KCl 20 mM CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 18.75727298042991, 15.220908858559348 in pocket 8433369 10.1006/jmbi.1993.1077 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6977 576 164 F153V Endolysin Enterobacteria phage T4 3.5 1.8 yes KH2PO4 10 mM 64.88 KCl 20 mM CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 18.75727298042991, 15.220908858559348 in pocket 8433369 10.1006/jmbi.1993.1077 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 7515 576 164 F153V Endolysin Enterobacteria phage T4 2.5 1.8 yes KH2PO4 20 mM 51.76 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 18.75727298042991, 15.220908858559348 in pocket 8433369 10.1006/jmbi.1993.1077 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 965 577 164 F153I Endolysin Enterobacteria phage T4 107.0 -1.5 yes 50.26 KH2PO4 20 mM KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 18.75727298042991, 15.220908858559348 in pocket 8433369 10.1006/jmbi.1993.1077 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 975 577 164 F153I Endolysin Enterobacteria phage T4 128.0 -0.5 yes 64.38 KH2PO4 10 mM KCl 20 mM CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 18.75727298042991, 15.220908858559348 in pocket 8433369 10.1006/jmbi.1993.1077 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6978 577 164 F153I Endolysin Enterobacteria phage T4 3.5 0.2 yes KH2PO4 10 mM 64.88 KCl 20 mM CD Thermal 5.7 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 18.75727298042991, 15.220908858559348 in pocket 8433369 10.1006/jmbi.1993.1077 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 7516 577 164 F153I Endolysin Enterobacteria phage T4 2.5 0.5 yes KH2PO4 20 mM 51.76 KCl 25 mM CD Thermal 3.01 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 18.75727298042991, 15.220908858559348 in pocket 8433369 10.1006/jmbi.1993.1077 1993 ProTherm capriotti_S1615_map.csv 12623 5838 164 F153C Endolysin Enterobacteria phage T4 4.7 3.11 Unknown imidazole,MOPS, 0.05 M,0.05 M, 22.0 Gel electrophoresis Urea 7.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 18.75727298042991, 15.220908858559348 in pocket 1988046 10.1021/bi00216a038 1991 ProTherm SAAFEC_S1262.csv 73 59 164 R154E Endolysin Enterobacteria phage T4 0.6 yes 51.5 Potassium phosphate 20 mM KCl 25 mM CD Thermal 2.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 47.28545448996804, 31.00090928511186 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm AUTOMUTE_S1749.csv, HotMuSiC_S1626.csv, Saraboji_S1791.csv 78 59 164 R154E Endolysin Enterobacteria phage T4 -2.6 yes 64.1 Potassium phosphate 20 mM KCl 25 mM CD Thermal 5.3 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 47.28545448996804, 31.00090928511186 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6714 59 164 R154E Endolysin Enterobacteria phage T4 1.1 yes Potassium phosphate 20 mM 66.7 KCl 25 mM CD Thermal 5.3 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 47.28545448996804, 31.00090928511186 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm capriotti_S1615_map.csv 7618 59 164 R154E Endolysin Enterobacteria phage T4 -0.2 yes Potassium phosphate 20 mM 50.9 KCl 25 mM CD Thermal 2.8 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 47.28545448996804, 31.00090928511186 in pocket 1942034 10.1016/0022-2836(91)80181-s 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 15490 7188 164 T155A, T157I Endolysin Enterobacteria phage T4 4.2 4.31 Unknown imidazole,MOPS, 0.05 M,0.05 M, 22.0 Gel electrophoresis Urea 7.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0, 5.0 1L63, 2LZM 22.82285717555455, 19.707142966134207, 21.235714503696986, 17.16714300428118 1988046 10.1021/bi00216a038 1991 ProTherm 624 361 164 G156D Endolysin Enterobacteria phage T4 -5.0 yes 46.6 HCl CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 18.390000104904175, 21.240000247955322 3323816 10.1016/0076-6879(87)54093-9 1987 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 828 361 164 G156D Endolysin Enterobacteria phage T4 -5.1 yes 36.8 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 18.390000104904175, 21.240000247955322 3680274 10.2210/pdb1l16/pdb 1987 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 829 361 164 G156D Endolysin Enterobacteria phage T4 -6.1 yes 58.6 Unknown KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 18.390000104904175, 21.240000247955322 3680274 10.2210/pdb1l16/pdb 1987 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7004 361 164 G156D Endolysin Enterobacteria phage T4 2.3 yes Unknown 64.7 KCl 0.2 M CD Thermal 6.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 18.390000104904175, 21.240000247955322 3680274 10.2210/pdb1l16/pdb 1987 ProTherm capriotti_S1615_map.csv 8051 361 164 G156D Endolysin Enterobacteria phage T4 1.4 yes Unknown 41.9 KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 18.390000104904175, 21.240000247955322 3680274 10.2210/pdb1l16/pdb 1987 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 12624 361 164 G156D Endolysin Enterobacteria phage T4 4.3 4.07 Unknown imidazole,MOPS, 0.05 M,0.05 M, 22.0 Gel electrophoresis Urea 7.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 8.0 1L63, 2LZM 18.390000104904175, 21.240000247955322 1988046 10.1021/bi00216a038 1991 ProTherm SAAFEC_S1262.csv 625 362 164 T157I Endolysin Enterobacteria phage T4 -11.0 yes 40.6 HCl CD Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 3323816 10.1016/0076-6879(87)54093-9 1987 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 638 362 164 T157I Endolysin Enterobacteria phage T4 -11.0 yes 31.0 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 3118211 10.1038/330041a0 1987 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 689 362 164 T157I Endolysin Enterobacteria phage T4 -5.8 yes 57.0 Sodium acetate 20 mM KCl 0.2 M CD Thermal 4.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 3681997 10.1016/0022-2836(87)90126-4 1987 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 690 362 164 T157I Endolysin Enterobacteria phage T4 -3.0 yes 61.5 Potassium phosphate 20 mM KCl 0.2 M CD Thermal 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 3681997 10.1016/0022-2836(87)90126-4 1987 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 856 362 164 T157I Endolysin Enterobacteria phage T4 yes 38.8 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm 863 362 164 T157I Endolysin Enterobacteria phage T4 yes 46.2 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm 870 362 164 T157I Endolysin Enterobacteria phage T4 yes 53.6 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm 7020 362 164 T157I Endolysin Enterobacteria phage T4 1.2 yes Potassium phosphate 20 mM 64.5 KCl 0.2 M CD Thermal 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 3681997 10.1016/0022-2836(87)90126-4 1987 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 7060 362 164 T157I Endolysin Enterobacteria phage T4 2.1 yes Sodium acetate 20 mM 62.8 KCl 0.2 M CD Thermal 4.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 3681997 10.1016/0022-2836(87)90126-4 1987 ProTherm capriotti_S1615_map.csv 7323 362 164 T157I Endolysin Enterobacteria phage T4 3.11 1.5 yes Potassium phosphate 20 mM 53.6 KCl 25 mM DSC Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm capriotti_S1615_map.csv 7841 362 164 T157I Endolysin Enterobacteria phage T4 3.11 1.9 yes Potassium phosphate 20 mM 46.2 KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 8028 362 164 T157I Endolysin Enterobacteria phage T4 2.9 yes Unknown 42.0 KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 3118211 10.1038/330041a0 1987 ProTherm capriotti_S1615_map.csv 8205 362 164 T157I Endolysin Enterobacteria phage T4 2.1 yes Potassium phosphate 20 mM 38.8 KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm capriotti_S1615_map.csv 626 363 164 T157N Endolysin Enterobacteria phage T4 -1.7 yes 40.3 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 3118211 10.1038/330041a0 1987 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 858 363 164 T157N Endolysin Enterobacteria phage T4 yes 38.8 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm 865 363 164 T157N Endolysin Enterobacteria phage T4 yes 46.2 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm 872 363 164 T157N Endolysin Enterobacteria phage T4 yes 53.6 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm 7325 363 164 T157N Endolysin Enterobacteria phage T4 3.37 1.2 yes Potassium phosphate 20 mM 53.6 KCl 25 mM DSC Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm capriotti_S1615_map.csv 7843 363 164 T157N Endolysin Enterobacteria phage T4 3.37 1.1 yes Potassium phosphate 20 mM 46.2 KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm capriotti_S1615_map.csv 8016 363 164 T157N Endolysin Enterobacteria phage T4 0.45 yes Unknown 42.0 KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 3118211 10.1038/330041a0 1987 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 8207 363 164 T157N Endolysin Enterobacteria phage T4 1.0 yes Potassium phosphate 20 mM 38.8 KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 627 364 164 T157S Endolysin Enterobacteria phage T4 -2.5 yes 39.5 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 3118211 10.1038/330041a0 1987 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8017 364 164 T157S Endolysin Enterobacteria phage T4 0.66 yes Unknown 42.0 KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 3118211 10.1038/330041a0 1987 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 628 365 164 T157D Endolysin Enterobacteria phage T4 -4.2 yes 37.8 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 3118211 10.1038/330041a0 1987 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8018 365 164 T157D Endolysin Enterobacteria phage T4 1.1 yes Unknown 42.0 KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 3118211 10.1038/330041a0 1987 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 12625 365 164 T157D Endolysin Enterobacteria phage T4 5.1 2.39 Unknown imidazole,MOPS, 0.05 M,0.05 M, 22.0 Gel electrophoresis Urea 7.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1988046 10.1021/bi00216a038 1991 ProTherm SAAFEC_S1262.csv 629 366 164 T157G Endolysin Enterobacteria phage T4 -4.2 yes 37.8 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 3118211 10.1038/330041a0 1987 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8019 366 164 T157G Endolysin Enterobacteria phage T4 1.1 yes Unknown 42.0 KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 3118211 10.1038/330041a0 1987 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 630 367 164 T157C Endolysin Enterobacteria phage T4 -4.9 yes 37.1 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 3118211 10.1038/330041a0 1987 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8020 367 164 T157C Endolysin Enterobacteria phage T4 1.3 yes Unknown 42.0 KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 3118211 10.1038/330041a0 1987 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 631 368 164 T157L Endolysin Enterobacteria phage T4 -5.0 yes 37.0 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 3118211 10.1038/330041a0 1987 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 857 368 164 T157L Endolysin Enterobacteria phage T4 yes 38.8 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm 864 368 164 T157L Endolysin Enterobacteria phage T4 yes 46.2 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm 871 368 164 T157L Endolysin Enterobacteria phage T4 yes 53.6 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm 7324 368 164 T157L Endolysin Enterobacteria phage T4 1.74 1.7 yes Potassium phosphate 20 mM 53.6 KCl 25 mM DSC Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 7842 368 164 T157L Endolysin Enterobacteria phage T4 1.74 1.7 yes Potassium phosphate 20 mM 46.2 KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 8021 368 164 T157L Endolysin Enterobacteria phage T4 1.3 yes Unknown 42.0 KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 3118211 10.1038/330041a0 1987 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 8206 368 164 T157L Endolysin Enterobacteria phage T4 1.7 yes Potassium phosphate 20 mM 38.8 KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 632 369 164 T157R Endolysin Enterobacteria phage T4 -5.1 yes 36.9 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 3118211 10.1038/330041a0 1987 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 859 369 164 T157R Endolysin Enterobacteria phage T4 yes 38.8 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm 866 369 164 T157R Endolysin Enterobacteria phage T4 yes 46.2 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm 873 369 164 T157R Endolysin Enterobacteria phage T4 yes 53.6 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm 7326 369 164 T157R Endolysin Enterobacteria phage T4 2.65 -0.3 yes Potassium phosphate 20 mM 53.6 KCl 25 mM DSC Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 7844 369 164 T157R Endolysin Enterobacteria phage T4 2.65 0.6 yes Potassium phosphate 20 mM 46.2 KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 8022 369 164 T157R Endolysin Enterobacteria phage T4 1.3 yes Unknown 42.0 KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 3118211 10.1038/330041a0 1987 ProTherm capriotti_S1615_map.csv 8208 369 164 T157R Endolysin Enterobacteria phage T4 1.1 yes Potassium phosphate 20 mM 38.8 KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm capriotti_S1615_map.csv 633 370 164 T157A Endolysin Enterobacteria phage T4 -5.4 yes 36.6 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 3118211 10.1038/330041a0 1987 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 854 370 164 T157A Endolysin Enterobacteria phage T4 yes 38.8 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm 861 370 164 T157A Endolysin Enterobacteria phage T4 yes 46.2 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm 868 370 164 T157A Endolysin Enterobacteria phage T4 yes 53.6 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm 7321 370 164 T157A Endolysin Enterobacteria phage T4 2.43 0.5 yes Potassium phosphate 20 mM 53.6 KCl 25 mM DSC Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 7839 370 164 T157A Endolysin Enterobacteria phage T4 0.9 yes Potassium phosphate 20 mM 46.2 KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm capriotti_S1615_map.csv 8023 370 164 T157A Endolysin Enterobacteria phage T4 1.4 yes Unknown 42.0 KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 3118211 10.1038/330041a0 1987 ProTherm capriotti_S1615_map.csv 8203 370 164 T157A Endolysin Enterobacteria phage T4 1.1 yes Potassium phosphate 20 mM 38.8 KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm capriotti_S1615_map.csv 634 371 164 T157E Endolysin Enterobacteria phage T4 -5.8 yes 36.2 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 3118211 10.1038/330041a0 1987 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 855 371 164 T157E Endolysin Enterobacteria phage T4 yes 38.8 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm 862 371 164 T157E Endolysin Enterobacteria phage T4 yes 46.2 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm 869 371 164 T157E Endolysin Enterobacteria phage T4 yes 53.6 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm 7322 371 164 T157E Endolysin Enterobacteria phage T4 2.3 0.8 yes Potassium phosphate 20 mM 53.6 KCl 25 mM DSC Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 7840 371 164 T157E Endolysin Enterobacteria phage T4 1.3 yes Potassium phosphate 20 mM 46.2 KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 8024 371 164 T157E Endolysin Enterobacteria phage T4 1.5 yes Unknown 42.0 KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 3118211 10.1038/330041a0 1987 ProTherm capriotti_S1615_map.csv 8204 371 164 T157E Endolysin Enterobacteria phage T4 1.5 yes Potassium phosphate 20 mM 38.8 KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm capriotti_S1615_map.csv 635 372 164 T157V Endolysin Enterobacteria phage T4 -6.0 yes 36.0 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 3118211 10.1038/330041a0 1987 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 860 372 164 T157V Endolysin Enterobacteria phage T4 yes 38.8 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm 867 372 164 T157V Endolysin Enterobacteria phage T4 yes 46.2 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm 874 372 164 T157V Endolysin Enterobacteria phage T4 yes 53.6 Potassium phosphate 20 mM KCl 25 mM DSC Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm 7327 372 164 T157V Endolysin Enterobacteria phage T4 2.45 1.2 yes Potassium phosphate 20 mM 53.6 KCl 25 mM DSC Thermal 3.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 7845 372 164 T157V Endolysin Enterobacteria phage T4 2.45 1.6 yes Potassium phosphate 20 mM 46.2 KCl 25 mM DSC Thermal 2.5 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm capriotti_S1615_map.csv 8025 372 164 T157V Endolysin Enterobacteria phage T4 1.6 yes Unknown 42.0 KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 3118211 10.1038/330041a0 1987 ProTherm capriotti_S1615_map.csv 8209 372 164 T157V Endolysin Enterobacteria phage T4 1.7 yes Potassium phosphate 20 mM 38.8 KCl 25 mM DSC Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1993203 10.1021/bi00221a022 1991 ProTherm capriotti_S1615_map.csv 636 373 164 T157H Endolysin Enterobacteria phage T4 -7.9 yes 34.1 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 3118211 10.1038/330041a0 1987 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8026 373 164 T157H Endolysin Enterobacteria phage T4 2.1 yes Unknown 42.0 KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 3118211 10.1038/330041a0 1987 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 637 374 164 T157F Endolysin Enterobacteria phage T4 -9.2 yes 32.8 Unknown KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 3118211 10.1038/330041a0 1987 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8027 374 164 T157F Endolysin Enterobacteria phage T4 2.4 yes Unknown 42.0 KCl 0.2 M CD Thermal 2.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 3118211 10.1038/330041a0 1987 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 12626 374 164 T157F Endolysin Enterobacteria phage T4 4.3 4.07 Unknown imidazole,MOPS, 0.05 M,0.05 M, 22.0 Gel electrophoresis Urea 7.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 5.0 1L63, 2LZM 19.707142966134207, 17.16714300428118 1988046 10.1021/bi00216a038 1991 ProTherm SAAFEC_S1262.csv 3622 1878 164 D159C Endolysin Enterobacteria phage T4 0.7 yes 37.1 Potassium phosphate 20 mM KCl 25 mM CD Thermal 2.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 3.0 1L63, 2LZM 32.237499475479126, 33.25375032424927 1510962 10.1021/bi00149a004 1992 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3032 1617 164 A160T Endolysin Enterobacteria phage T4 -5.5 Unknown 60.0 Unknown CD Thermal 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 17.749999809265137, 16.23600025177002 3689874 10.1002/bip.360261104 1987 ProTherm AUTOMUTE_S1962.csv, AUTOMUTE_S1749.csv, Broom_S605.csv, Saraboji_S1791.csv, Saraboji_S2204.csv, STRUM_Q306.csv, STRUM_Q3421.csv 6766 1617 164 A160T Endolysin Enterobacteria phage T4 1.65 Unknown Unknown 65.5 CD Thermal 6.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 17.749999809265137, 16.23600025177002 3689874 10.1002/bip.360261104 1987 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 12627 1617 164 A160T Endolysin Enterobacteria phage T4 4.0 4.55 Unknown imidazole,MOPS, 0.05 M,0.05 M, 22.0 Gel electrophoresis Urea 7.0 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 6.0 1L63, 2LZM 17.749999809265137, 16.23600025177002 1988046 10.1021/bi00216a038 1991 ProTherm SAAFEC_S1262.csv 200 106 164 N163D Endolysin Enterobacteria phage T4 3.5 141.0 -0.5 Unknown 64.75 Sodium acetate 10 mM NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 63.36874961853027 7507755 10.1002/pro.5560021221 1993 ProTherm Saraboji_S1791.csv 212 106 164 N163D Endolysin Enterobacteria phage T4 3.5 -0.49 Unknown 61.7 Potassium phosphate 0.01 M KCl 0.15 M CD Thermal 6.78 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 63.36874961853027 7507755 10.1002/pro.5560021221 1993 ProTherm Saraboji_S1791.csv 6829 106 164 N163D Endolysin Enterobacteria phage T4 3.5 0.21 Unknown Sodium acetate 10 mM 65.15 NaCl 0.10 M CD Thermal 5.4 3.2.1.17 P00720 IPR034690:Endolysin_T4_type, IPR002196:Glyco_hydro_24, IPR023346:Lysozyme-like_dom_sf, IPR023347:Lysozyme_dom_sf, IPR052619:Phage_lysozyme-like, IPR001165:T4-type_lysozyme 7.0 1L63, 2LZM 63.36874961853027 7507755 10.1002/pro.5560021221 1993 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 17467 48 148 Lysozyme C Homo sapiens yes 57.5 glycine hydrochloride 0.05 M DSC Thermal 2.2 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 11015217 10.1021/bi000849s 2000 ProTherm 17468 48 148 Lysozyme C Homo sapiens yes 80.1 sodium acetate 0.02 M DSC Thermal 4.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 11015217 10.1021/bi000849s 2000 ProTherm 17469 48 148 Lysozyme C Homo sapiens yes 56.2 glycine hydrochloride 0.05 M KCl 0.2 M DSC Thermal 2.3 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 11015217 10.1021/bi000849s 2000 ProTherm 17470 48 148 Lysozyme C Homo sapiens yes 77.7 sodium acetate 0.02 M KCl 0.2 M DSC Thermal 4.5 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 11015217 10.1021/bi000849s 2000 ProTherm 17535 48 148 Lysozyme C Homo sapiens yes 71.4 glycine-HCl 0.05 M DSC Thermal 3.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1525170 10.1021/bi00150a028 1992 ProTherm 18120 48 148 Lysozyme C Homo sapiens 1.58 yes 68.8 glycine-HCl 50 mM DSC Thermal 2.8 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1643041 10.1021/bi00146a008 1992 ProTherm 18132 48 148 Lysozyme C Homo sapiens 1.58 114.01 yes 64.9 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 11087397 10.1021/bi0015717 2000 ProTherm 18133 48 148 Lysozyme C Homo sapiens yes 64.9 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 11087397 10.1021/bi0015717 2000 ProTherm 18377 48 148 Lysozyme C Homo sapiens 1.67 81.82 yes 49.2 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 18378 48 148 Lysozyme C Homo sapiens 96.4 97.4 yes 57.8 glycine 0.05 M DSC Thermal 3.14 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 18379 48 148 Lysozyme C Homo sapiens 91.6 95.0 yes 55.4 glycine 0.05 M DSC Thermal 3.04 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 18380 48 148 Lysozyme C Homo sapiens 85.9 89.2 yes 52.0 glycine 0.05 M DSC Thermal 2.81 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 18381 48 148 Lysozyme C Homo sapiens 82.5 85.4 yes 49.2 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 18382 48 148 Lysozyme C Homo sapiens 75.4 79.8 yes 45.5 glycine 0.05 M DSC Thermal 2.53 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 18383 48 148 Lysozyme C Homo sapiens 1.58 114.1 120.1 yes 64.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9649316 10.1021/bi980431i 1998 ProTherm 18402 48 148 Lysozyme C Homo sapiens 1.58 yes 64.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9398521 10.1006/jmbi.1997.1365 1997 ProTherm 19121 48 148 Lysozyme C Homo sapiens 1.58 114.01 yes 64.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10350481 10.1021/bi9901228 1999 ProTherm 19354 48 148 Lysozyme C Homo sapiens 1.58 114.01 yes 64.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10469827 10.1093/protein/12.8.663 1999 ProTherm 19388 48 148 Lysozyme C Homo sapiens 1.58 114.01 119.98 yes 64.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10556244 10.1093/protein/12.10.841 1999 ProTherm 19691 48 148 Lysozyme C Homo sapiens 1.58 114.1 120.1 yes 64.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7473760 10.1006/jmbi.1995.0599 1995 ProTherm 19697 48 148 Lysozyme C Homo sapiens 1.94 90.58 96.32 yes 55.6 glycine-HCl 50 mM DSC Thermal 2.63 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10810162 10.1093/protein/13.4.299 2000 ProTherm 19698 48 148 Lysozyme C Homo sapiens 1.63 95.12 95.6 yes 56.4 glycine-HCl 50 mM DSC Thermal 2.64 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10810162 10.1093/protein/13.4.299 2000 ProTherm 19699 48 148 Lysozyme C Homo sapiens 1.94 92.02 96.32 yes 56.8 glycine-HCl 50 mM DSC Thermal 2.68 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10810162 10.1093/protein/13.4.299 2000 ProTherm 19700 48 148 Lysozyme C Homo sapiens 1.77 97.51 98.95 yes 58.2 glycine-HCl 50 mM DSC Thermal 2.75 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10810162 10.1093/protein/13.4.299 2000 ProTherm 19701 48 148 Lysozyme C Homo sapiens 1.31 97.99 101.1 yes 59.0 glycine-HCl 50 mM DSC Thermal 2.78 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10810162 10.1093/protein/13.4.299 2000 ProTherm 19702 48 148 Lysozyme C Homo sapiens 1.67 98.47 103.01 yes 60.3 glycine-HCl 50 mM DSC Thermal 2.84 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10810162 10.1093/protein/13.4.299 2000 ProTherm 19703 48 148 Lysozyme C Homo sapiens 1.7 98.95 98.95 yes 60.5 glycine-HCl 50 mM DSC Thermal 2.87 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10810162 10.1093/protein/13.4.299 2000 ProTherm 19704 48 148 Lysozyme C Homo sapiens 1.46 102.06 102.06 yes 62.5 glycine-HCl 50 mM DSC Thermal 2.93 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10810162 10.1093/protein/13.4.299 2000 ProTherm 19705 48 148 Lysozyme C Homo sapiens 1.79 102.06 102.06 yes 62.8 glycine-HCl 50 mM DSC Thermal 3.03 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10810162 10.1093/protein/13.4.299 2000 ProTherm 19709 48 148 Lysozyme C Homo sapiens 1.58 114.1 120.1 yes 64.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9010773 10.1093/oxfordjournals.jbchem.a021544 1996 ProTherm 19721 48 148 Lysozyme C Homo sapiens 1.58 114.1 120.1 yes 64.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9020766 10.1021/bi9621829 1997 ProTherm 19740 48 148 Lysozyme C Homo sapiens yes 64.9 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10913274 10.1021/bi9928694 2000 ProTherm 19741 48 148 Lysozyme C Homo sapiens 1.58 114.01 yes 64.9 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10913274 10.1021/bi9928694 2000 ProTherm 19865 48 148 Lysozyme C Homo sapiens 1.55 114.01 yes 64.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10561612 10.1046/j.1432-1327.1999.00918.x 1999 ProTherm 20134 48 148 Lysozyme C Homo sapiens 1.58 120.1 yes glycine-HCl 50 mM 68.8 DSC Thermal 2.8 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1643041 10.1021/bi00146a008 1992 ProTherm 20135 48 148 Lysozyme C Homo sapiens 1.58 114.1 120.1 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9398521 10.1006/jmbi.1997.1365 1997 ProTherm 20145 48 148 Lysozyme C Homo sapiens 1.55 4.6 100.6 yes glycine-HCl 0.05 M 57.0 DSC Thermal 3.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1525170 10.1021/bi00150a028 1992 ProTherm 20664 48 148 Lysozyme C Homo sapiens 2.97 9.7 5.52 yes (100%) glycine-HCl 40 mM 25.0 CD GdnHCl 3.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1911779 10.1021/bi00105a011 1991 ProTherm 21305 48 148 Lysozyme C Homo sapiens 2.9 9.49 3.23 yes glycine-HCl 50 mM 25.0 DSC GdnHCl 3.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10810162 10.1093/protein/13.4.299 2000 ProTherm 21306 48 148 Lysozyme C Homo sapiens 3.8 12.86 3.37 yes glycine-HCl 50 mM 25.0 DSC GdnHCl 4.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10810162 10.1093/protein/13.4.299 2000 ProTherm 21307 48 148 Lysozyme C Homo sapiens 4.0 12.05 3.01 yes Sodium phosphate 50 mM 25.0 DSC GdnHCl 7.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10810162 10.1093/protein/13.4.299 2000 ProTherm 21308 48 148 Lysozyme C Homo sapiens 2.1 6.19 3.01 yes glycine-HCl 50 mM 25.0 DSC GdnHCl 3.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10810162 10.1093/protein/13.4.299 2000 ProTherm 21309 48 148 Lysozyme C Homo sapiens 2.8 8.25 2.96 yes glycine-HCl 50 mM 25.0 DSC GdnHCl 4.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10810162 10.1093/protein/13.4.299 2000 ProTherm 21310 48 148 Lysozyme C Homo sapiens 2.9 8.51 2.96 yes Sodium phosphate 50 mM 25.0 DSC GdnHCl 7.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10810162 10.1093/protein/13.4.299 2000 ProTherm 21767 48 148 Lysozyme C Homo sapiens 4.12 14.7 3.6 yes Sodium acetate 20 mM 20.0 CD GdnHCl 5.2 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10727242 10.1021/bi9921945 2000 ProTherm 21995 48 148 Lysozyme C Homo sapiens 14.0 yes glycine-HCl 40 mM 10.0 CD GdnHCl 4.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1537844 1992 ProTherm 21996 48 148 Lysozyme C Homo sapiens 11.8 yes glycine-HCl 40 mM 10.0 Fluorescence GdnHCl 3.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1537844 1992 ProTherm 21997 48 148 Lysozyme C Homo sapiens 3.96 14.34 yes glycine-HCl 40 mM 10.0 CD GdnHCl 4.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10913274 10.1021/bi9928694 2000 ProTherm 22332 48 148 Lysozyme C Homo sapiens 1.58 yes 64.9 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 11599030 10.1002/prot.1147 2001 ProTherm 22333 48 148 Lysozyme C Homo sapiens 1.58 114.01 yes 64.9 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 11599030 10.1002/prot.1147 2001 ProTherm 22488 48 148 Lysozyme C Homo sapiens 1.58 114.01 Unknown 64.9 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 11927576 10.1074/jbc.M110728200 2002 ProTherm 27285 48 148 Lysozyme C Homo sapiens 4.0 13.98 3.54 yes Gly-HCl 40 mM 10.0 CD GdnHCl 4.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 11121116 10.1046/j.1432-1327.2001.01863.x 2001 ProTherm 4242 2158 148 K19M Lysozyme C Homo sapiens 88.43 90.11 yes 61.7 glycine 0.05 M DSC Thermal 2.5 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 20.721111085679794 in pocket 10561612 10.1046/j.1432-1327.1999.00918.x 1999 ProTherm 4243 2158 148 K19M Lysozyme C Homo sapiens 92.26 101.1 yes 64.7 glycine 0.05 M DSC Thermal 2.78 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 20.721111085679794 in pocket 10561612 10.1046/j.1432-1327.1999.00918.x 1999 ProTherm 4244 2158 148 K19M Lysozyme C Homo sapiens 95.36 97.51 yes 69.1 glycine 0.05 M DSC Thermal 2.95 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 20.721111085679794 in pocket 10561612 10.1046/j.1432-1327.1999.00918.x 1999 ProTherm 4245 2158 148 K19M Lysozyme C Homo sapiens 98.47 106.12 yes 70.1 glycine 0.05 M DSC Thermal 3.22 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 20.721111085679794 in pocket 10561612 10.1046/j.1432-1327.1999.00918.x 1999 ProTherm 4249 2158 148 K19M Lysozyme C Homo sapiens 1.03 91.78 -0.5 yes 64.4 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 20.721111085679794 in pocket 10561612 10.1046/j.1432-1327.1999.00918.x 1999 ProTherm 4251 2158 148 K19M Lysozyme C Homo sapiens yes 64.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 20.721111085679794 in pocket 10561612 10.1046/j.1432-1327.1999.00918.x 1999 ProTherm 6937 2158 148 K19M Lysozyme C Homo sapiens 0.12 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 20.721111085679794 in pocket 10561612 10.1046/j.1432-1327.1999.00918.x 1999 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 4246 2159 148 K19A Lysozyme C Homo sapiens 90.58 98.71 yes 60.9 glycine 0.05 M DSC Thermal 2.58 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 20.721111085679794 in pocket 10561612 10.1046/j.1432-1327.1999.00918.x 1999 ProTherm 4247 2159 148 K19A Lysozyme C Homo sapiens 95.12 99.43 yes 63.7 glycine 0.05 M DSC Thermal 2.77 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 20.721111085679794 in pocket 10561612 10.1046/j.1432-1327.1999.00918.x 1999 ProTherm 4248 2159 148 K19A Lysozyme C Homo sapiens 99.19 110.42 yes 66.3 glycine 0.05 M DSC Thermal 2.97 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 20.721111085679794 in pocket 10561612 10.1046/j.1432-1327.1999.00918.x 1999 ProTherm 4250 2159 148 K19A Lysozyme C Homo sapiens 1.6 96.8 -2.2 yes 62.7 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 20.721111085679794 in pocket 10561612 10.1046/j.1432-1327.1999.00918.x 1999 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4252 2159 148 K19A Lysozyme C Homo sapiens yes 64.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 20.721111085679794 in pocket 10561612 10.1046/j.1432-1327.1999.00918.x 1999 ProTherm 6938 2159 148 K19A Lysozyme C Homo sapiens 0.6 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 20.721111085679794 in pocket 10561612 10.1046/j.1432-1327.1999.00918.x 1999 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1100 670 148 V20G Lysozyme C Homo sapiens 95.6 yes 56.63 glycine-HCl 0.05 M DSC Thermal 2.65 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11087397 10.1021/bi0015717 2000 ProTherm 1101 670 148 V20G Lysozyme C Homo sapiens 99.67 yes 59.46 glycine-HCl 0.05 M DSC Thermal 2.83 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11087397 10.1021/bi0015717 2000 ProTherm 1102 670 148 V20G Lysozyme C Homo sapiens 104.92 yes 63.75 glycine-HCl 0.05 M DSC Thermal 3.08 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11087397 10.1021/bi0015717 2000 ProTherm 1103 670 148 V20G Lysozyme C Homo sapiens 108.03 yes 65.7 glycine-HCl 0.05 M DSC Thermal 3.19 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11087397 10.1021/bi0015717 2000 ProTherm 1104 670 148 V20G Lysozyme C Homo sapiens 112.09 yes 69.03 glycine-HCl 0.05 M DSC Thermal 3.4 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11087397 10.1021/bi0015717 2000 ProTherm 1166 670 148 V20G Lysozyme C Homo sapiens 1.31 106.6 -7.5 yes 57.4 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11087397 10.1021/bi0015717 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 1181 670 148 V20G Lysozyme C Homo sapiens yes 64.9 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11087397 10.1021/bi0015717 2000 ProTherm 6939 670 148 V20G Lysozyme C Homo sapiens 2.29 yes glycine-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11087397 10.1021/bi0015717 2000 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1105 671 148 V20I Lysozyme C Homo sapiens 108.03 yes 65.06 glycine-HCl 0.05 M DSC Thermal 2.5 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11087397 10.1021/bi0015717 2000 ProTherm 1106 671 148 V20I Lysozyme C Homo sapiens 114.01 yes 67.98 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11087397 10.1021/bi0015717 2000 ProTherm 1107 671 148 V20I Lysozyme C Homo sapiens 119.02 yes 72.23 glycine-HCl 0.05 M DSC Thermal 2.92 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11087397 10.1021/bi0015717 2000 ProTherm 1108 671 148 V20I Lysozyme C Homo sapiens 125.0 yes 75.47 glycine-HCl 0.05 M DSC Thermal 3.13 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11087397 10.1021/bi0015717 2000 ProTherm 1167 671 148 V20I Lysozyme C Homo sapiens 1.58 108.03 3.4 yes 68.3 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11087397 10.1021/bi0015717 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 1182 671 148 V20I Lysozyme C Homo sapiens yes 64.9 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11087397 10.1021/bi0015717 2000 ProTherm 6940 671 148 V20I Lysozyme C Homo sapiens -1.1 yes glycine-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11087397 10.1021/bi0015717 2000 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1109 672 148 V20L Lysozyme C Homo sapiens 105.16 yes 61.34 glycine-HCl 0.05 M DSC Thermal 2.49 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11087397 10.1021/bi0015717 2000 ProTherm 1110 672 148 V20L Lysozyme C Homo sapiens 108.99 yes 64.55 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11087397 10.1021/bi0015717 2000 ProTherm 1111 672 148 V20L Lysozyme C Homo sapiens 116.16 yes 70.39 glycine-HCl 0.05 M DSC Thermal 3.05 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11087397 10.1021/bi0015717 2000 ProTherm HotMuSiC_S1626.csv 1168 672 148 V20L Lysozyme C Homo sapiens 1.22 109.46 -0.2 yes 64.7 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11087397 10.1021/bi0015717 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 1183 672 148 V20L Lysozyme C Homo sapiens yes 64.9 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11087397 10.1021/bi0015717 2000 ProTherm 6941 672 148 V20L Lysozyme C Homo sapiens 0.05 yes glycine-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11087397 10.1021/bi0015717 2000 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1112 673 148 V20M Lysozyme C Homo sapiens 106.12 yes 60.62 glycine-HCl 0.05 M DSC Thermal 2.52 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11087397 10.1021/bi0015717 2000 ProTherm 1113 673 148 V20M Lysozyme C Homo sapiens 112.09 yes 64.55 glycine-HCl 0.05 M DSC Thermal 2.73 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11087397 10.1021/bi0015717 2000 ProTherm 1114 673 148 V20M Lysozyme C Homo sapiens 118.07 yes 68.26 glycine-HCl 0.05 M DSC Thermal 2.94 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11087397 10.1021/bi0015717 2000 ProTherm 1115 673 148 V20M Lysozyme C Homo sapiens 121.89 yes 70.56 glycine-HCl 0.05 M DSC Thermal 3.09 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11087397 10.1021/bi0015717 2000 ProTherm 1116 673 148 V20M Lysozyme C Homo sapiens 126.91 yes 74.24 glycine-HCl 0.05 M DSC Thermal 3.31 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11087397 10.1021/bi0015717 2000 ProTherm 1169 673 148 V20M Lysozyme C Homo sapiens 1.55 112.57 -1.0 yes 63.9 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11087397 10.1021/bi0015717 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 1184 673 148 V20M Lysozyme C Homo sapiens yes 64.9 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11087397 10.1021/bi0015717 2000 ProTherm 6942 673 148 V20M Lysozyme C Homo sapiens 0.31 yes glycine-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11087397 10.1021/bi0015717 2000 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1117 674 148 V20F Lysozyme C Homo sapiens 106.12 yes 61.97 glycine-HCl 0.05 M DSC Thermal 2.68 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11087397 10.1021/bi0015717 2000 ProTherm 1118 674 148 V20F Lysozyme C Homo sapiens 109.94 yes 65.05 glycine-HCl 0.05 M DSC Thermal 2.87 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11087397 10.1021/bi0015717 2000 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv 1119 674 148 V20F Lysozyme C Homo sapiens 115.92 yes 68.6 glycine-HCl 0.05 M DSC Thermal 3.09 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11087397 10.1021/bi0015717 2000 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv 1120 674 148 V20F Lysozyme C Homo sapiens 120.94 yes 71.22 glycine-HCl 0.05 M DSC Thermal 3.22 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11087397 10.1021/bi0015717 2000 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 1170 674 148 V20F Lysozyme C Homo sapiens 1.63 110.18 -2.7 yes 62.2 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11087397 10.1021/bi0015717 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 1185 674 148 V20F Lysozyme C Homo sapiens yes 64.9 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11087397 10.1021/bi0015717 2000 ProTherm 6943 674 148 V20F Lysozyme C Homo sapiens 0.86 yes glycine-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11087397 10.1021/bi0015717 2000 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1254 718 148 V20S Lysozyme C Homo sapiens 103.01 103.01 Unknown 59.4 Gly-HCl 0.05 M DSC Thermal 2.65 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11927576 10.1074/jbc.M110728200 2002 ProTherm 1255 718 148 V20S Lysozyme C Homo sapiens 108.03 107.07 Unknown 62.9 Gly-HCl 0.05 M DSC Thermal 2.83 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11927576 10.1074/jbc.M110728200 2002 ProTherm 1256 718 148 V20S Lysozyme C Homo sapiens 114.96 114.01 Unknown 67.1 Gly-HCl 0.05 M DSC Thermal 3.09 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11927576 10.1074/jbc.M110728200 2002 ProTherm 1257 718 148 V20S Lysozyme C Homo sapiens 118.07 119.02 Unknown 69.4 Gly-HCl 0.05 M DSC Thermal 3.24 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11927576 10.1074/jbc.M110728200 2002 ProTherm 1258 718 148 V20S Lysozyme C Homo sapiens 124.04 125.96 Unknown 73.0 Gly-HCl 0.05 M DSC Thermal 3.45 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11927576 10.1074/jbc.M110728200 2002 ProTherm 1317 718 148 V20S Lysozyme C Homo sapiens -4.4 Unknown 60.5 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11927576 10.1074/jbc.M110728200 2002 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6954 718 148 V20S Lysozyme C Homo sapiens 1.55 1.41 111.14 Unknown Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11927576 10.1074/jbc.M110728200 2002 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1259 719 148 V20Y Lysozyme C Homo sapiens 108.03 110.18 Unknown 65.9 Gly-HCl 0.05 M DSC Thermal 2.83 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11927576 10.1074/jbc.M110728200 2002 ProTherm 1260 719 148 V20Y Lysozyme C Homo sapiens 111.14 112.09 Unknown 67.4 Gly-HCl 0.05 M DSC Thermal 2.91 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11927576 10.1074/jbc.M110728200 2002 ProTherm 1261 719 148 V20Y Lysozyme C Homo sapiens 119.02 119.98 Unknown 72.3 Gly-HCl 0.05 M DSC Thermal 3.2 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11927576 10.1074/jbc.M110728200 2002 ProTherm 1262 719 148 V20Y Lysozyme C Homo sapiens 119.98 119.98 Unknown 72.0 Gly-HCl 0.05 M DSC Thermal 3.21 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11927576 10.1074/jbc.M110728200 2002 ProTherm 1263 719 148 V20Y Lysozyme C Homo sapiens 121.18 122.13 Unknown 73.0 Gly-HCl 0.05 M DSC Thermal 3.24 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11927576 10.1074/jbc.M110728200 2002 ProTherm 1318 719 148 V20Y Lysozyme C Homo sapiens -1.2 Unknown 63.7 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11927576 10.1074/jbc.M110728200 2002 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6955 719 148 V20Y Lysozyme C Homo sapiens 1.82 0.36 106.12 Unknown Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11927576 10.1074/jbc.M110728200 2002 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1264 720 148 V20D Lysozyme C Homo sapiens 103.01 99.9 Unknown 59.6 Gly-HCl 0.05 M DSC Thermal 2.66 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11927576 10.1074/jbc.M110728200 2002 ProTherm 1265 720 148 V20D Lysozyme C Homo sapiens 112.09 108.03 Unknown 64.9 Gly-HCl 0.05 M DSC Thermal 2.96 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11927576 10.1074/jbc.M110728200 2002 ProTherm 1266 720 148 V20D Lysozyme C Homo sapiens 113.05 108.99 Unknown 65.7 Gly-HCl 0.05 M DSC Thermal 3.01 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11927576 10.1074/jbc.M110728200 2002 ProTherm 1267 720 148 V20D Lysozyme C Homo sapiens 115.92 113.05 Unknown 68.0 Gly-HCl 0.05 M DSC Thermal 3.14 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11927576 10.1074/jbc.M110728200 2002 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 1268 720 148 V20D Lysozyme C Homo sapiens 119.98 118.07 Unknown 70.2 Gly-HCl 0.05 M DSC Thermal 3.3 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11927576 10.1074/jbc.M110728200 2002 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, EASE-MM_S1676.csv, PON-TStab_dataset.csv, HotMuSiC_S1626.csv 1319 720 148 V20D Lysozyme C Homo sapiens -4.5 Unknown 60.4 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6956 720 148 V20D Lysozyme C Homo sapiens 1.58 1.43 111.38 Unknown Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11927576 10.1074/jbc.M110728200 2002 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1269 721 148 V20N Lysozyme C Homo sapiens 103.97 99.9 Unknown 59.1 Gly-HCl 0.05 M DSC Thermal 2.6 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv, AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 1270 721 148 V20N Lysozyme C Homo sapiens 109.94 104.92 Unknown 62.7 Gly-HCl 0.05 M DSC Thermal 2.82 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv 1271 721 148 V20N Lysozyme C Homo sapiens 113.05 108.99 Unknown 64.3 Gly-HCl 0.05 M DSC Thermal 2.91 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11927576 10.1074/jbc.M110728200 2002 ProTherm 1272 721 148 V20N Lysozyme C Homo sapiens 117.11 110.9 Unknown 66.3 Gly-HCl 0.05 M DSC Thermal 3.01 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11927576 10.1074/jbc.M110728200 2002 ProTherm 1320 721 148 V20N Lysozyme C Homo sapiens -4.1 Unknown 60.8 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6957 721 148 V20N Lysozyme C Homo sapiens 1.7 1.34 113.77 Unknown Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11927576 10.1074/jbc.M110728200 2002 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1273 722 148 V20R Lysozyme C Homo sapiens 103.01 109.94 Unknown 62.1 Gly-HCl 0.05 M DSC Thermal 2.6 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv 1274 722 148 V20R Lysozyme C Homo sapiens 108.03 114.96 Unknown 66.4 Gly-HCl 0.05 M DSC Thermal 2.88 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv 1275 722 148 V20R Lysozyme C Homo sapiens 112.09 119.98 Unknown 68.6 Gly-HCl 0.05 M DSC Thermal 2.99 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv 1276 722 148 V20R Lysozyme C Homo sapiens 114.01 123.09 Unknown 70.7 Gly-HCl 0.05 M DSC Thermal 3.15 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv 1277 722 148 V20R Lysozyme C Homo sapiens 119.98 125.96 Unknown 74.1 Gly-HCl 0.05 M DSC Thermal 3.3 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv 1321 722 148 V20R Lysozyme C Homo sapiens -1.3 Unknown 63.6 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6958 722 148 V20R Lysozyme C Homo sapiens 1.41 0.38 106.36 Unknown Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 11927576 10.1074/jbc.M110728200 2002 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3189 1723 148 V20A Lysozyme C Homo sapiens 1.44 65.55 -7.9 yes 41.3 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 9677301 10.1006/jmbi.1998.1906 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3220 1723 148 V20A Lysozyme C Homo sapiens 65.1 70.6 yes 48.3 glycine 0.05 M DSC Thermal 3.1 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3221 1723 148 V20A Lysozyme C Homo sapiens 62.0 67.5 yes 47.3 glycine 0.05 M DSC Thermal 3.02 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3222 1723 148 V20A Lysozyme C Homo sapiens 54.5 60.3 yes 41.4 glycine 0.05 M DSC Thermal 2.71 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 4165 1723 148 V20A Lysozyme C Homo sapiens 1.56 111.96 114.2 -4.6 yes 60.3 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 9020766 10.1021/bi9621829 1997 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6888 1723 148 V20A Lysozyme C Homo sapiens 1.56 1.51 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 9020766 10.1021/bi9621829 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 7743 1723 148 V20A Lysozyme C Homo sapiens 1.44 1.51 yes glycine 0.05 M 49.2 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.771428516932897 9677301 10.1006/jmbi.1998.1906 1998 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 44 44 148 E25Q Lysozyme C Homo sapiens 0.3 yes 57.8 glycine hydrochloride 0.05 M DSC Thermal 2.2 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 17.856666882832844 11015217 10.1021/bi000849s 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 50 44 148 E25Q Lysozyme C Homo sapiens -3.9 yes 76.2 sodium acetate 0.02 M DSC Thermal 4.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 17.856666882832844 11015217 10.1021/bi000849s 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 56 44 148 E25Q Lysozyme C Homo sapiens -1.6 yes 54.6 glycine hydrochloride 0.05 M KCl 0.2 M DSC Thermal 2.3 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 17.856666882832844 11015217 10.1021/bi000849s 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 60 44 148 E25Q Lysozyme C Homo sapiens -2.2 yes 75.5 sodium acetate 0.02 M KCl 0.2 M DSC Thermal 4.5 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 17.856666882832844 11015217 10.1021/bi000849s 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6837 44 148 E25Q Lysozyme C Homo sapiens 1.43 3.99 yes sodium acetate 0.02 M 65.0 DSC Thermal 4.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 17.856666882832844 11015217 10.1021/bi000849s 2000 ProTherm 6843 44 148 E25Q Lysozyme C Homo sapiens 1.29 2.77 yes sodium acetate 0.02 M 65.0 KCl 0.2 M DSC Thermal 4.5 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 17.856666882832844 11015217 10.1021/bi000849s 2000 ProTherm 311 172 148 L26T Lysozyme C Homo sapiens 1.39 -12.4 yes 52.5 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 1LZ1 9.892500102519989 11294653 10.1021/bi002792f 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6847 172 148 L26T Lysozyme C Homo sapiens 1.39 106.6 yes Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 1LZ1 9.892500102519989 11294653 10.1021/bi002792f 2001 ProTherm 6855 172 148 L26T Lysozyme C Homo sapiens 3.73 yes Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 1LZ1 9.892500102519989 11294653 10.1021/bi002792f 2001 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 312 173 148 A27S Lysozyme C Homo sapiens 1.27 -0.1 yes 64.8 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 9.739999771118164 11294653 10.1021/bi002792f 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6848 173 148 A27S Lysozyme C Homo sapiens 1.27 106.12 yes Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 9.739999771118164 11294653 10.1021/bi002792f 2001 ProTherm 6856 173 148 A27S Lysozyme C Homo sapiens 0.02 yes Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 9.739999771118164 11294653 10.1021/bi002792f 2001 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3712 1937 148 T29A Lysozyme C Homo sapiens 119.26 119.98 yes 73.4 glycine-HCl 0.05 M DSC Thermal 3.22 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 11.71142850603376 in pocket 10504240 10.1021/bi9910169 1999 ProTherm 3713 1937 148 T29A Lysozyme C Homo sapiens 115.92 119.02 yes 71.4 glycine-HCl 0.05 M DSC Thermal 3.02 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 11.71142850603376 in pocket 10504240 10.1021/bi9910169 1999 ProTherm 3714 1937 148 T29A Lysozyme C Homo sapiens 114.96 115.92 yes 68.5 glycine-HCl 0.05 M DSC Thermal 2.82 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 11.71142850603376 in pocket 10504240 10.1021/bi9910169 1999 ProTherm 3715 1937 148 T29A Lysozyme C Homo sapiens 112.09 114.96 yes 66.8 glycine-HCl 0.05 M DSC Thermal 2.74 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 11.71142850603376 in pocket 10504240 10.1021/bi9910169 1999 ProTherm 3716 1937 148 T29A Lysozyme C Homo sapiens 104.92 110.9 yes 63.7 glycine-HCl 0.05 M DSC Thermal 2.58 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 11.71142850603376 in pocket 10504240 10.1021/bi9910169 1999 ProTherm 3736 1942 148 T29V Lysozyme C Homo sapiens 117.11 120.94 yes 73.0 glycine-HCl 0.05 M DSC Thermal 3.19 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 11.71142850603376 in pocket 10504240 10.1021/bi9910169 1999 ProTherm STRUM_Q3421.csv 3737 1942 148 T29V Lysozyme C Homo sapiens 114.01 117.11 yes 68.7 glycine-HCl 0.05 M DSC Thermal 2.81 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 11.71142850603376 in pocket 10504240 10.1021/bi9910169 1999 ProTherm STRUM_Q3421.csv 3738 1942 148 T29V Lysozyme C Homo sapiens 109.94 112.09 yes 66.2 glycine-HCl 0.05 M DSC Thermal 2.71 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 11.71142850603376 in pocket 10504240 10.1021/bi9910169 1999 ProTherm STRUM_Q3421.csv 3739 1942 148 T29V Lysozyme C Homo sapiens 103.97 107.07 yes 62.9 glycine-HCl 0.05 M DSC Thermal 2.51 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 11.71142850603376 in pocket 10504240 10.1021/bi9910169 1999 ProTherm STRUM_Q3421.csv 505 287 148 G34A Lysozyme C Homo sapiens 96.32 yes 60.3 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 12.737500190734863 11599030 10.1002/prot.1147 2001 ProTherm 529 287 148 G34A Lysozyme C Homo sapiens 103.49 -4.6 yes 60.3 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 12.737500190734863 11599030 10.1002/prot.1147 2001 ProTherm 6872 287 148 G34A Lysozyme C Homo sapiens 1.58 1.39 yes Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 12.737500190734863 11599030 10.1002/prot.1147 2001 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 45 45 148 D36N Lysozyme C Homo sapiens -1.5 yes 56.0 glycine hydrochloride 0.05 M DSC Thermal 2.2 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 19.09249985218048 11015217 10.1021/bi000849s 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 51 45 148 D36N Lysozyme C Homo sapiens -4.6 yes 75.5 sodium acetate 0.02 M DSC Thermal 4.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 19.09249985218048 11015217 10.1021/bi000849s 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6838 45 148 D36N Lysozyme C Homo sapiens 1.7 3.73 yes sodium acetate 0.02 M 65.0 DSC Thermal 4.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 19.09249985218048 11015217 10.1021/bi000849s 2000 ProTherm 506 288 148 G37A Lysozyme C Homo sapiens 102.06 yes 59.4 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 13.932499647140503 11599030 10.1002/prot.1147 2001 ProTherm 530 288 148 G37A Lysozyme C Homo sapiens 110.66 -5.5 yes 59.4 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 13.932499647140503 11599030 10.1002/prot.1147 2001 ProTherm 6873 288 148 G37A Lysozyme C Homo sapiens 1.58 1.77 yes Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 13.932499647140503 11599030 10.1002/prot.1147 2001 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3262 1732 148 Y38F Lysozyme C Homo sapiens 1.35 111.5 119.9 -1.5 yes 63.4 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 13.37916668256124 9649316 10.1021/bi980431i 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3268 1732 148 Y38F Lysozyme C Homo sapiens 0.6 122.0 129.19 yes 72.0 glycine 0.05 M DSC Thermal 3.18 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 13.37916668256124 9649316 10.1021/bi980431i 1998 ProTherm 3269 1732 148 Y38F Lysozyme C Homo sapiens 1.24 119.1 127.03 yes 69.8 glycine 0.05 M DSC Thermal 3.06 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 13.37916668256124 9649316 10.1021/bi980431i 1998 ProTherm 3270 1732 148 Y38F Lysozyme C Homo sapiens 1.7 115.1 123.21 yes 66.8 glycine 0.05 M DSC Thermal 2.89 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 13.37916668256124 9649316 10.1021/bi980431i 1998 ProTherm 3271 1732 148 Y38F Lysozyme C Homo sapiens 1.27 109.1 118.18 yes 64.3 glycine 0.05 M DSC Thermal 2.74 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 13.37916668256124 9649316 10.1021/bi980431i 1998 ProTherm 3272 1732 148 Y38F Lysozyme C Homo sapiens 1.67 106.2 114.11 yes 61.1 glycine 0.05 M DSC Thermal 2.58 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 13.37916668256124 9649316 10.1021/bi980431i 1998 ProTherm 6897 1732 148 Y38F Lysozyme C Homo sapiens 1.35 0.5 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 13.37916668256124 9649316 10.1021/bi980431i 1998 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 332 188 148 R39A Lysozyme C Homo sapiens 98.71 107.07 yes 66.1 Gly-HCl 0.05 M DSC Thermal 2.51 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 41.366363525390625 11455596 10.1002/prot.1088 2001 ProTherm HotMuSiC_S1626.csv 333 188 148 R39A Lysozyme C Homo sapiens 106.12 113.05 yes 69.8 Gly-HCl 0.05 M DSC Thermal 2.71 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 41.366363525390625 11455596 10.1002/prot.1088 2001 ProTherm HotMuSiC_S1626.csv 334 188 148 R39A Lysozyme C Homo sapiens 108.99 113.05 yes 72.4 Gly-HCl 0.05 M DSC Thermal 2.87 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 41.366363525390625 11455596 10.1002/prot.1088 2001 ProTherm 335 188 148 R39A Lysozyme C Homo sapiens 119.98 129.06 yes 77.6 Gly-HCl 0.05 M DSC Thermal 3.23 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 41.366363525390625 11455596 10.1002/prot.1088 2001 ProTherm 363 188 148 R39A Lysozyme C Homo sapiens 1.82 96.56 4.5 yes 69.4 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 41.366363525390625 11455596 10.1002/prot.1088 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6863 188 148 R39A Lysozyme C Homo sapiens -1.31 yes Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 41.366363525390625 11455596 10.1002/prot.1088 2001 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 336 189 148 R39G Lysozyme C Homo sapiens 102.06 107.07 yes 64.6 Gly-HCl 0.05 M DSC Thermal 2.5 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 41.366363525390625 11455596 10.1002/prot.1088 2001 ProTherm 337 189 148 R39G Lysozyme C Homo sapiens 108.99 113.05 yes 68.2 Gly-HCl 0.05 M DSC Thermal 2.69 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 41.366363525390625 11455596 10.1002/prot.1088 2001 ProTherm HotMuSiC_S1626.csv 338 189 148 R39G Lysozyme C Homo sapiens 113.05 115.92 yes 70.9 Gly-HCl 0.05 M DSC Thermal 2.81 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 41.366363525390625 11455596 10.1002/prot.1088 2001 ProTherm HotMuSiC_S1626.csv 364 189 148 R39G Lysozyme C Homo sapiens 1.74 102.77 3.7 yes 68.6 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 41.366363525390625 11455596 10.1002/prot.1088 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6864 189 148 R39G Lysozyme C Homo sapiens -1.15 yes Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 41.366363525390625 11455596 10.1002/prot.1088 2001 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 507 289 148 G40A Lysozyme C Homo sapiens 76.96 yes 57.7 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 10.767500162124634 11599030 10.1002/prot.1147 2001 ProTherm 531 289 148 G40A Lysozyme C Homo sapiens 88.43 -7.2 yes 57.7 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 10.767500162124634 11599030 10.1002/prot.1147 2001 ProTherm 6874 289 148 G40A Lysozyme C Homo sapiens 1.58 1.79 yes Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 10.767500162124634 11599030 10.1002/prot.1147 2001 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3184 1718 148 I41V Lysozyme C Homo sapiens 1.82 80.86 -1.6 yes 47.6 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 10.84499990940094 9677301 10.1006/jmbi.1998.1906 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3198 1718 148 I41V Lysozyme C Homo sapiens 91.1 95.0 yes 55.0 glycine 0.05 M DSC Thermal 3.09 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 10.84499990940094 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3199 1718 148 I41V Lysozyme C Homo sapiens 85.4 89.2 yes 52.3 glycine 0.05 M DSC Thermal 2.96 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 10.84499990940094 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3200 1718 148 I41V Lysozyme C Homo sapiens 83.5 85.9 yes 49.6 glycine 0.05 M DSC Thermal 2.78 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 10.84499990940094 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3201 1718 148 I41V Lysozyme C Homo sapiens 76.3 80.4 yes 46.7 glycine 0.05 M DSC Thermal 2.66 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 10.84499990940094 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3202 1718 148 I41V Lysozyme C Homo sapiens 69.9 74.6 yes 43.5 glycine 0.05 M DSC Thermal 2.49 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 10.84499990940094 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 4153 1718 148 I41V Lysozyme C Homo sapiens 1.39 112.0 120.3 -1.1 yes 63.8 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 10.84499990940094 7473760 10.1006/jmbi.1995.0599 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6882 1718 148 I41V Lysozyme C Homo sapiens 1.39 0.36 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 10.84499990940094 7473760 10.1006/jmbi.1995.0599 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 7738 1718 148 I41V Lysozyme C Homo sapiens 1.82 0.41 yes glycine 0.05 M 49.2 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 10.84499990940094 9677301 10.1006/jmbi.1998.1906 1998 ProTherm capriotti_S1615_map.csv 3328 1753 148 I41A Lysozyme C Homo sapiens 1.08 105.0 111.0 yes 62.0 glycine 0.05 M DSC Thermal 2.96 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 10.84499990940094 9398521 10.1006/jmbi.1997.1365 1997 ProTherm 3329 1753 148 I41A Lysozyme C Homo sapiens 1.51 98.1 103.1 yes 56.2 glycine 0.05 M DSC Thermal 2.67 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 10.84499990940094 9398521 10.1006/jmbi.1997.1365 1997 ProTherm 3356 1753 148 I41A Lysozyme C Homo sapiens 1.2 -8.1 yes 56.8 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 10.84499990940094 9398521 10.1006/jmbi.1997.1365 1997 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6903 1753 148 I41A Lysozyme C Homo sapiens 1.2 2.54 108.6 115.5 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 10.84499990940094 9398521 10.1006/jmbi.1997.1365 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 3636 1888 148 S42A Lysozyme C Homo sapiens 1.41 118.07 123.09 yes 70.3 glycine 0.05 M -- DSC Thermal 3.09 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 11.015000184377035 10350481 10.1021/bi9901228 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 3637 1888 148 S42A Lysozyme C Homo sapiens 1.55 112.09 117.11 yes 65.7 glycine 0.05 M DSC Thermal 2.82 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 11.015000184377035 10350481 10.1021/bi9901228 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, Broom_S605.csv 3638 1888 148 S42A Lysozyme C Homo sapiens 1.67 106.12 110.9 yes 62.5 glycine 0.05 M DSC Thermal 2.66 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 11.015000184377035 10350481 10.1021/bi9901228 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 3639 1888 148 S42A Lysozyme C Homo sapiens 1.46 101.1 104.92 yes 58.8 glycine 0.05 M DSC Thermal 2.46 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 11.015000184377035 10350481 10.1021/bi9901228 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 3660 1888 148 S42A Lysozyme C Homo sapiens 1.51 110.18 -1.6 yes 63.3 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 11.015000184377035 10350481 10.1021/bi9901228 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3878 2016 148 N45L Lysozyme C Homo sapiens yes 65.3 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 11.426249980926514 10469827 10.1093/protein/12.8.663 1999 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, SVM-WIN31_SVM-3D12_S499.csv, M47andM8_S1810.csv 3905 2016 148 N45L Lysozyme C Homo sapiens 0.4 yes 65.3 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 11.426249980926514 10469827 10.1093/protein/12.8.663 1999 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, EASE-MM_S1676.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 313 174 148 A50S Lysozyme C Homo sapiens 1.65 -1.0 yes 63.9 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 1LZ1 11.534000205993653 11294653 10.1021/bi002792f 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6849 174 148 A50S Lysozyme C Homo sapiens 1.65 110.66 yes Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 1LZ1 11.534000205993653 11294653 10.1021/bi002792f 2001 ProTherm 6857 174 148 A50S Lysozyme C Homo sapiens 0.33 yes Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 1LZ1 11.534000205993653 11294653 10.1021/bi002792f 2001 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3879 2017 148 A50L Lysozyme C Homo sapiens 94.89 97.75 yes 63.1 glycine 0.05 M DSC Thermal 2.61 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 1LZ1 11.534000205993653 10469827 10.1093/protein/12.8.663 1999 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, SVM-WIN31_SVM-3D12_S499.csv, iPTREE-STAB_S1859.csv 3880 2017 148 A50L Lysozyme C Homo sapiens 102.06 103.97 yes 66.9 glycine 0.05 M DSC Thermal 2.83 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 1LZ1 11.534000205993653 10469827 10.1093/protein/12.8.663 1999 ProTherm 3881 2017 148 A50L Lysozyme C Homo sapiens 108.03 110.9 yes 73.2 glycine 0.05 M DSC Thermal 3.23 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 1LZ1 11.534000205993653 10469827 10.1093/protein/12.8.663 1999 ProTherm 3906 2017 148 A50L Lysozyme C Homo sapiens 1.27 98.23 -0.3 yes 64.6 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 1LZ1 11.534000205993653 10469827 10.1093/protein/12.8.663 1999 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, EASE-MM_S1676.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3915 2017 148 A50L Lysozyme C Homo sapiens yes 64.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 1LZ1 11.534000205993653 10469827 10.1093/protein/12.8.663 1999 ProTherm 6909 2017 148 A50L Lysozyme C Homo sapiens 0.1 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 1LZ1 11.534000205993653 10469827 10.1093/protein/12.8.663 1999 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3882 2018 148 E53L Lysozyme C Homo sapiens 94.89 104.92 yes 61.2 glycine 0.05 M DSC Thermal 2.56 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf active site 8.0 1LZ1 15.47888904147678 in tunnel in pocket 10469827 10.1093/protein/12.8.663 1999 ProTherm 3883 2018 148 E53L Lysozyme C Homo sapiens 104.92 109.94 yes 70.8 glycine 0.05 M DSC Thermal 3.25 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf active site 8.0 1LZ1 15.47888904147678 in tunnel in pocket 10469827 10.1093/protein/12.8.663 1999 ProTherm 3907 2018 148 E53L Lysozyme C Homo sapiens 1.05 98.95 -1.8 yes 63.1 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf active site 8.0 1LZ1 15.47888904147678 in tunnel in pocket 10469827 10.1093/protein/12.8.663 1999 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, M47andM8_S1810.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3916 2018 148 E53L Lysozyme C Homo sapiens yes 64.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf active site 8.0 1LZ1 15.47888904147678 in tunnel in pocket 10469827 10.1093/protein/12.8.663 1999 ProTherm 6910 2018 148 E53L Lysozyme C Homo sapiens 0.53 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf active site 8.0 1LZ1 15.47888904147678 in tunnel in pocket 10469827 10.1093/protein/12.8.663 1999 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3640 1889 148 S54A Lysozyme C Homo sapiens 1.22 114.01 119.02 yes 68.7 glycine 0.05 M DSC Thermal 3.09 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 12.480000178019205 10350481 10.1021/bi9901228 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 3641 1889 148 S54A Lysozyme C Homo sapiens 1.24 107.07 113.05 yes 64.0 glycine 0.05 M DSC Thermal 2.84 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 12.480000178019205 10350481 10.1021/bi9901228 1999 ProTherm EASE-MM_S238.csv, PON-TStab_dataset.csv 3642 1889 148 S54A Lysozyme C Homo sapiens 1.31 103.97 108.99 yes 60.8 glycine 0.05 M DSC Thermal 2.67 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 12.480000178019205 10350481 10.1021/bi9901228 1999 ProTherm 3643 1889 148 S54A Lysozyme C Homo sapiens 1.31 98.47 103.01 yes 57.1 glycine 0.05 M DSC Thermal 2.47 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 12.480000178019205 10350481 10.1021/bi9901228 1999 ProTherm 3661 1889 148 S54A Lysozyme C Homo sapiens 1.31 108.75 -3.5 yes 61.4 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 12.480000178019205 10350481 10.1021/bi9901228 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 508 290 148 G55A Lysozyme C Homo sapiens 97.04 yes 58.1 Gly-HCl 0.05 M DSC Thermal 2.38 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 14.75249981880188 11599030 10.1002/prot.1147 2001 ProTherm 509 290 148 G55A Lysozyme C Homo sapiens 103.97 yes 62.4 Gly-HCl 0.05 M DSC Thermal 2.6 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 14.75249981880188 11599030 10.1002/prot.1147 2001 ProTherm HotMuSiC_S1626.csv 510 290 148 G55A Lysozyme C Homo sapiens 119.02 yes 72.4 Gly-HCl 0.05 M DSC Thermal 3.18 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 14.75249981880188 11599030 10.1002/prot.1147 2001 ProTherm HotMuSiC_S1626.csv 532 290 148 G55A Lysozyme C Homo sapiens 1.53 107.55 -0.9 yes 64.0 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 14.75249981880188 11599030 10.1002/prot.1147 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6875 290 148 G55A Lysozyme C Homo sapiens 1.53 0.29 yes Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 14.75249981880188 11599030 10.1002/prot.1147 2001 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3884 2019 148 G55Q Lysozyme C Homo sapiens 102.06 108.03 yes 60.7 glycine 0.05 M DSC Thermal 2.48 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 14.75249981880188 10469827 10.1093/protein/12.8.663 1999 ProTherm 3885 2019 148 G55Q Lysozyme C Homo sapiens 108.03 110.9 yes 64.5 glycine 0.05 M DSC Thermal 2.73 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 14.75249981880188 10469827 10.1093/protein/12.8.663 1999 ProTherm 3886 2019 148 G55Q Lysozyme C Homo sapiens 113.05 118.07 yes 70.1 glycine 0.05 M DSC Thermal 3.09 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 14.75249981880188 10469827 10.1093/protein/12.8.663 1999 ProTherm 3908 2019 148 G55Q Lysozyme C Homo sapiens 1.15 107.55 -0.8 yes 64.1 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 14.75249981880188 10469827 10.1093/protein/12.8.663 1999 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, M47andM8_S1810.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3917 2019 148 G55Q Lysozyme C Homo sapiens yes 64.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 14.75249981880188 10469827 10.1093/protein/12.8.663 1999 ProTherm 4204 2019 148 G55Q Lysozyme C Homo sapiens -0.8 yes 64.1 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 14.75249981880188 10913274 10.1021/bi9928694 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4208 2019 148 G55Q Lysozyme C Homo sapiens 1.15 107.55 yes 64.9 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 14.75249981880188 10913274 10.1021/bi9928694 2000 ProTherm 6911 2019 148 G55Q Lysozyme C Homo sapiens 0.26 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 14.75249981880188 10469827 10.1093/protein/12.8.663 1999 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 6936 2019 148 G55Q Lysozyme C Homo sapiens 1.15 0.26 107.55 yes glycine-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 14.75249981880188 10913274 10.1021/bi9928694 2000 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14096 2019 148 G55Q Lysozyme C Homo sapiens 3.79 0.86 13.48 yes glycine-HCl 40 mM 10.0 CD GdnHCl 4.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 14.75249981880188 10913274 10.1021/bi9928694 2000 ProTherm 339 190 148 Y56A Lysozyme C Homo sapiens 87.95 89.15 yes 56.3 Gly-HCl 0.05 M DSC Thermal 2.72 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 13.084999958674112 11455596 10.1002/prot.1088 2001 ProTherm HotMuSiC_S1626.csv 340 190 148 Y56A Lysozyme C Homo sapiens 94.41 96.32 yes 61.7 Gly-HCl 0.05 M DSC Thermal 3.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 13.084999958674112 11455596 10.1002/prot.1088 2001 ProTherm HotMuSiC_S1626.csv 341 190 148 Y56A Lysozyme C Homo sapiens 96.32 97.51 yes 65.0 Gly-HCl 0.05 M DSC Thermal 3.18 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 13.084999958674112 11455596 10.1002/prot.1088 2001 ProTherm 365 190 148 Y56A Lysozyme C Homo sapiens 0.98 96.8 -8.9 yes 56.0 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 13.084999958674112 11455596 10.1002/prot.1088 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6865 190 148 Y56A Lysozyme C Homo sapiens 2.49 yes Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 13.084999958674112 11455596 10.1002/prot.1088 2001 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 342 191 148 Y56G Lysozyme C Homo sapiens 85.8 87.0 yes 53.0 Gly-HCl 0.05 M DSC Thermal 2.5 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 13.084999958674112 11455596 10.1002/prot.1088 2001 ProTherm 343 191 148 Y56G Lysozyme C Homo sapiens 90.11 92.26 yes 58.5 Gly-HCl 0.05 M DSC Thermal 2.78 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 13.084999958674112 11455596 10.1002/prot.1088 2001 ProTherm HotMuSiC_S1626.csv 344 191 148 Y56G Lysozyme C Homo sapiens 97.75 99.67 yes 65.6 Gly-HCl 0.05 M DSC Thermal 3.24 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 13.084999958674112 11455596 10.1002/prot.1088 2001 ProTherm HotMuSiC_S1626.csv 366 191 148 Y56G Lysozyme C Homo sapiens 0.96 96.8 -8.2 yes 56.7 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 13.084999958674112 11455596 10.1002/prot.1088 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6866 191 148 Y56G Lysozyme C Homo sapiens 2.32 yes Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 13.084999958674112 11455596 10.1002/prot.1088 2001 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3263 1733 148 Y56F Lysozyme C Homo sapiens 1.29 113.6 117.2 -0.6 yes 64.3 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 13.084999958674112 9649316 10.1021/bi980431i 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3273 1733 148 Y56F Lysozyme C Homo sapiens 1.12 123.2 126.18 Yes 72.4 glycine 0.05 M DSC Thermal 3.25 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 13.084999958674112 9649316 10.1021/bi980431i 1998 ProTherm 3274 1733 148 Y56F Lysozyme C Homo sapiens 0.96 121.1 124.16 yes 70.3 glycine 0.05 M DSC Thermal 3.1 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 13.084999958674112 9649316 10.1021/bi980431i 1998 ProTherm 3275 1733 148 Y56F Lysozyme C Homo sapiens 1.46 117.2 121.05 yes 67.2 glycine 0.05 M DSC Thermal 2.92 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 13.084999958674112 9649316 10.1021/bi980431i 1998 ProTherm 3276 1733 148 Y56F Lysozyme C Homo sapiens 1.03 113.2 117.22 yes 64.6 glycine 0.05 M DSC Thermal 2.71 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 13.084999958674112 9649316 10.1021/bi980431i 1998 ProTherm 6898 1733 148 Y56F Lysozyme C Homo sapiens 1.29 0.19 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 13.084999958674112 9649316 10.1021/bi980431i 1998 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 3717 1938 148 T58A Lysozyme C Homo sapiens 117.11 120.94 yes 68.6 glycine-HCl 0.05 M DSC Thermal 3.1 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 12.362857137407575 in pocket 10504240 10.1021/bi9910169 1999 ProTherm 3718 1938 148 T58A Lysozyme C Homo sapiens 114.01 117.11 yes 66.5 glycine-HCl 0.05 M DSC Thermal 3.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 12.362857137407575 in pocket 10504240 10.1021/bi9910169 1999 ProTherm 3719 1938 148 T58A Lysozyme C Homo sapiens 107.07 114.01 yes 63.3 glycine-HCl 0.05 M DSC Thermal 2.85 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 12.362857137407575 in pocket 10504240 10.1021/bi9910169 1999 ProTherm 3720 1938 148 T58A Lysozyme C Homo sapiens 99.9 102.06 yes 59.4 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 12.362857137407575 in pocket 10504240 10.1021/bi9910169 1999 ProTherm 3721 1938 148 T58A Lysozyme C Homo sapiens 97.51 103.01 yes 56.6 glycine-HCl 0.05 M DSC Thermal 2.5 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 12.362857137407575 in pocket 10504240 10.1021/bi9910169 1999 ProTherm 3740 1943 148 T58V Lysozyme C Homo sapiens 114.96 122.85 yes 68.7 glycine-HCl 0.05 M DSC Thermal 3.1 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 12.362857137407575 in pocket 10504240 10.1021/bi9910169 1999 ProTherm STRUM_Q3421.csv 3741 1943 148 T58V Lysozyme C Homo sapiens 112.09 119.02 yes 66.3 glycine-HCl 0.05 M DSC Thermal 3.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 12.362857137407575 in pocket 10504240 10.1021/bi9910169 1999 ProTherm STRUM_Q3421.csv 3742 1943 148 T58V Lysozyme C Homo sapiens 109.94 113.05 yes 63.2 glycine-HCl 0.05 M DSC Thermal 2.85 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 12.362857137407575 in pocket 10504240 10.1021/bi9910169 1999 ProTherm STRUM_Q3421.csv 3743 1943 148 T58V Lysozyme C Homo sapiens 92.97 99.9 yes 59.2 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 12.362857137407575 in pocket 10504240 10.1021/bi9910169 1999 ProTherm STRUM_Q3421.csv 3744 1943 148 T58V Lysozyme C Homo sapiens 96.56 103.97 yes 57.0 glycine-HCl 0.05 M DSC Thermal 2.5 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 12.362857137407575 in pocket 10504240 10.1021/bi9910169 1999 ProTherm STRUM_Q3421.csv, AUTOMUTE_S1962.csv, Saraboji_S2204.csv 3722 1939 148 T61A Lysozyme C Homo sapiens 114.01 114.01 yes 69.7 glycine-HCl 0.05 M DSC Thermal 3.08 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 20.52999986921038 10504240 10.1021/bi9910169 1999 ProTherm 3723 1939 148 T61A Lysozyme C Homo sapiens 110.9 112.09 yes 67.1 glycine-HCl 0.05 M DSC Thermal 2.9 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 20.52999986921038 10504240 10.1021/bi9910169 1999 ProTherm 3724 1939 148 T61A Lysozyme C Homo sapiens 108.03 108.99 yes 64.5 glycine-HCl 0.05 M DSC Thermal 2.74 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 20.52999986921038 10504240 10.1021/bi9910169 1999 ProTherm 3725 1939 148 T61A Lysozyme C Homo sapiens 103.97 104.92 yes 61.1 glycine-HCl 0.05 M DSC Thermal 2.54 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 20.52999986921038 10504240 10.1021/bi9910169 1999 ProTherm HotMuSiC_S1626.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv 3745 1944 148 T61V Lysozyme C Homo sapiens 113.05 120.94 yes 75.4 glycine-HCl 0.05 M DSC Thermal 3.2 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 20.52999986921038 10504240 10.1021/bi9910169 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 3746 1944 148 T61V Lysozyme C Homo sapiens 108.03 118.07 yes 73.0 glycine-HCl 0.05 M DSC Thermal 3.02 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 20.52999986921038 10504240 10.1021/bi9910169 1999 ProTherm STRUM_Q306.csv, STRUM_Q3421.csv 3747 1944 148 T61V Lysozyme C Homo sapiens 104.92 114.01 yes 68.4 glycine-HCl 0.05 M DSC Thermal 2.71 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 20.52999986921038 10504240 10.1021/bi9910169 1999 ProTherm AUTOMUTE_S1925.csv, AUTOMUTE_S1962.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 3748 1944 148 T61V Lysozyme C Homo sapiens 99.9 112.09 yes 65.0 glycine-HCl 0.05 M DSC Thermal 2.51 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 20.52999986921038 10504240 10.1021/bi9910169 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv 3264 1734 148 Y63F Lysozyme C Homo sapiens 1.1 112.2 118.1 0.2 yes 65.1 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 22.899999856948853 9649316 10.1021/bi980431i 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3277 1734 148 Y63F Lysozyme C Homo sapiens 1.63 121.1 127.03 yes 72.5 glycine 0.05 M DSC Thermal 3.13 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 22.899999856948853 9649316 10.1021/bi980431i 1998 ProTherm 3278 1734 148 Y63F Lysozyme C Homo sapiens 0.65 116.0 122.0 yes 68.7 glycine 0.05 M DSC Thermal 2.89 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 22.899999856948853 9649316 10.1021/bi980431i 1998 ProTherm 3279 1734 148 Y63F Lysozyme C Homo sapiens 1.15 111.0 117.22 yes 64.9 glycine 0.05 M DSC Thermal 2.71 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 22.899999856948853 9649316 10.1021/bi980431i 1998 ProTherm 3280 1734 148 Y63F Lysozyme C Homo sapiens 1.34 112.2 117.22 yes 64.6 glycine 0.05 M DSC Thermal 2.67 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 22.899999856948853 9649316 10.1021/bi980431i 1998 ProTherm 3281 1734 148 Y63F Lysozyme C Homo sapiens 0.89 109.1 115.07 yes 61.4 glycine 0.05 M DSC Thermal 2.48 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 22.899999856948853 9649316 10.1021/bi980431i 1998 ProTherm 6899 1734 148 Y63F Lysozyme C Homo sapiens 1.1 -0.07 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 22.899999856948853 9649316 10.1021/bi980431i 1998 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 1051 634 148 A65P Lysozyme C Homo sapiens 1.56 0.3 yes 69.1 glycine-HCl 50 mM DSC Thermal 2.8 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 36.68800010681152 1643041 10.1021/bi00146a008 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6704 634 148 A65P Lysozyme C Homo sapiens 1.56 -0.1 119.4 yes glycine-HCl 50 mM 68.8 DSC Thermal 2.8 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 36.68800010681152 1643041 10.1021/bi00146a008 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 9881 634 148 A65P Lysozyme C Homo sapiens 3.3 -1.1 10.8 5.5 yes (100%) glycine-HCl 40 mM 25.0 CD GdnHCl 3.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 36.68800010681152 1911779 10.1021/bi00105a011 1991 ProTherm 511 291 148 G66A Lysozyme C Homo sapiens 94.89 yes 61.1 Gly-HCl 0.05 M DSC Thermal 2.4 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 2.0 1LZ1 28.632500171661377 11599030 10.1002/prot.1147 2001 ProTherm HotMuSiC_S1626.csv 512 291 148 G66A Lysozyme C Homo sapiens 102.06 yes 66.0 Gly-HCl 0.05 M DSC Thermal 2.68 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 2.0 1LZ1 28.632500171661377 11599030 10.1002/prot.1147 2001 ProTherm 513 291 148 G66A Lysozyme C Homo sapiens 117.11 yes 75.1 Gly-HCl 0.05 M DSC Thermal 3.2 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 2.0 1LZ1 28.632500171661377 11599030 10.1002/prot.1147 2001 ProTherm 533 291 148 G66A Lysozyme C Homo sapiens 1.6 100.62 1.5 yes 66.4 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 2.0 1LZ1 28.632500171661377 11599030 10.1002/prot.1147 2001 ProTherm 6876 291 148 G66A Lysozyme C Homo sapiens 1.6 -0.45 yes Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 2.0 1LZ1 28.632500171661377 11599030 10.1002/prot.1147 2001 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 46 46 148 D67N Lysozyme C Homo sapiens 0.0 yes 57.5 glycine hydrochloride 0.05 M DSC Thermal 2.2 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 27.632500052452087 in tunnel in pocket 11015217 10.1021/bi000849s 2000 ProTherm khan_protherm_data_mapped.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 52 46 148 D67N Lysozyme C Homo sapiens -2.7 yes 77.4 sodium acetate 0.02 M DSC Thermal 4.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 27.632500052452087 in tunnel in pocket 11015217 10.1021/bi000849s 2000 ProTherm khan_protherm_data_mapped.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6839 46 148 D67N Lysozyme C Homo sapiens 1.0 4.42 yes sodium acetate 0.02 M 65.0 DSC Thermal 4.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 27.632500052452087 in tunnel in pocket 11015217 10.1021/bi000849s 2000 ProTherm khan_protherm_data_mapped.csv 345 192 148 R68A Lysozyme C Homo sapiens 101.1 108.03 yes 62.8 Gly-HCl 0.05 M DSC Thermal 2.5 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 38.71181817488237 11455596 10.1002/prot.1088 2001 ProTherm 346 192 148 R68A Lysozyme C Homo sapiens 106.12 113.05 yes 66.6 Gly-HCl 0.05 M DSC Thermal 2.71 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 38.71181817488237 11455596 10.1002/prot.1088 2001 ProTherm 347 192 148 R68A Lysozyme C Homo sapiens 108.99 117.11 yes 69.1 Gly-HCl 0.05 M DSC Thermal 2.84 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 38.71181817488237 11455596 10.1002/prot.1088 2001 ProTherm 348 192 148 R68A Lysozyme C Homo sapiens 114.01 120.94 yes 70.9 Gly-HCl 0.05 M DSC Thermal 3.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 38.71181817488237 11455596 10.1002/prot.1088 2001 ProTherm 367 192 148 R68A Lysozyme C Homo sapiens 1.51 103.97 1.4 yes 66.3 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 38.71181817488237 11455596 10.1002/prot.1088 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6867 192 148 R68A Lysozyme C Homo sapiens -0.43 yes Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 38.71181817488237 11455596 10.1002/prot.1088 2001 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3887 2020 148 R68G Lysozyme C Homo sapiens 99.9 110.9 yes 63.7 glycine 0.05 M DSC Thermal 2.58 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 38.71181817488237 10469827 10.1093/protein/12.8.663 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv 3888 2020 148 R68G Lysozyme C Homo sapiens 102.06 114.01 yes 67.3 glycine 0.05 M DSC Thermal 2.78 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 38.71181817488237 10469827 10.1093/protein/12.8.663 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv 3889 2020 148 R68G Lysozyme C Homo sapiens 113.05 123.09 yes 73.0 glycine 0.05 M DSC Thermal 3.11 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 38.71181817488237 10469827 10.1093/protein/12.8.663 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv 3909 2020 148 R68G Lysozyme C Homo sapiens 1.46 100.38 0.9 yes 65.8 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 38.71181817488237 10469827 10.1093/protein/12.8.663 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv, STRUM_Q3421.csv 3918 2020 148 R68G Lysozyme C Homo sapiens yes 64.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 38.71181817488237 10469827 10.1093/protein/12.8.663 1999 ProTherm 4201 2020 148 R68G Lysozyme C Homo sapiens 0.9 yes 65.8 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 38.71181817488237 10913274 10.1021/bi9928694 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4205 2020 148 R68G Lysozyme C Homo sapiens 1.46 100.38 yes 64.9 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 38.71181817488237 10913274 10.1021/bi9928694 2000 ProTherm 6912 2020 148 R68G Lysozyme C Homo sapiens -0.26 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 38.71181817488237 10469827 10.1093/protein/12.8.663 1999 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 6933 2020 148 R68G Lysozyme C Homo sapiens 1.46 -0.26 100.38 yes glycine-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 38.71181817488237 10913274 10.1021/bi9928694 2000 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14093 2020 148 R68G Lysozyme C Homo sapiens 4.11 -0.53 14.87 yes glycine-HCl 40 mM 10.0 CD GdnHCl 4.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 38.71181817488237 10913274 10.1021/bi9928694 2000 ProTherm 3644 1890 148 S69A Lysozyme C Homo sapiens 1.36 119.98 125.96 yes 70.8 glycine 0.05 M DSC Thermal 3.11 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 15.693333148956299 in tunnel 10350481 10.1021/bi9901228 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q306.csv, STRUM_Q3421.csv 3645 1890 148 S69A Lysozyme C Homo sapiens 1.55 114.96 120.94 yes 66.7 glycine 0.05 M DSC Thermal 2.86 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 15.693333148956299 in tunnel 10350481 10.1021/bi9901228 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, Broom_S605.csv 3646 1890 148 S69A Lysozyme C Homo sapiens 1.43 110.9 118.07 yes 64.2 glycine 0.05 M DSC Thermal 2.69 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 15.693333148956299 in tunnel 10350481 10.1021/bi9901228 1999 ProTherm AUTOMUTE_S1925.csv, AUTOMUTE_S1962.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 3647 1890 148 S69A Lysozyme C Homo sapiens 1.48 106.12 113.05 yes 61.0 glycine 0.05 M DSC Thermal 2.51 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 15.693333148956299 in tunnel 10350481 10.1021/bi9901228 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 3662 1890 148 S69A Lysozyme C Homo sapiens 1.43 111.85 -0.7 yes 64.2 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 15.693333148956299 in tunnel 10350481 10.1021/bi9901228 1999 ProTherm AUTOMUTE_S1962.csv, Broom_S605.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3726 1940 148 T70A Lysozyme C Homo sapiens 108.99 118.07 yes 68.9 glycine-HCl 0.05 M DSC Thermal 3.1 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 11.66714266368321 10504240 10.1021/bi9910169 1999 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, HotMuSiC_S1626.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, PoPMuSiC-2.0_S2648.csv, AUTOMUTE_S1962.csv, Saraboji_S2204.csv 3727 1940 148 T70A Lysozyme C Homo sapiens 108.03 114.01 yes 66.9 glycine-HCl 0.05 M DSC Thermal 3.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 11.66714266368321 10504240 10.1021/bi9910169 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 3728 1940 148 T70A Lysozyme C Homo sapiens 104.92 112.09 yes 64.4 glycine-HCl 0.05 M DSC Thermal 2.85 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 11.66714266368321 10504240 10.1021/bi9910169 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 3729 1940 148 T70A Lysozyme C Homo sapiens 103.01 108.99 yes 61.9 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 11.66714266368321 10504240 10.1021/bi9910169 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 3730 1940 148 T70A Lysozyme C Homo sapiens 98.71 103.97 yes 58.8 glycine-HCl 0.05 M DSC Thermal 2.5 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 11.66714266368321 10504240 10.1021/bi9910169 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 3749 1945 148 T70V Lysozyme C Homo sapiens 110.9 114.01 yes 68.7 glycine-HCl 0.05 M DSC Thermal 3.1 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 11.66714266368321 10504240 10.1021/bi9910169 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv 3750 1945 148 T70V Lysozyme C Homo sapiens 107.07 113.05 yes 66.6 glycine-HCl 0.05 M DSC Thermal 3.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 11.66714266368321 10504240 10.1021/bi9910169 1999 ProTherm 3751 1945 148 T70V Lysozyme C Homo sapiens 104.92 109.94 yes 64.2 glycine-HCl 0.05 M DSC Thermal 2.85 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 11.66714266368321 10504240 10.1021/bi9910169 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 3752 1945 148 T70V Lysozyme C Homo sapiens 102.06 107.07 yes 62.1 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 11.66714266368321 10504240 10.1021/bi9910169 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 3753 1945 148 T70V Lysozyme C Homo sapiens 98.71 103.97 yes 58.8 glycine-HCl 0.05 M DSC Thermal 2.5 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 11.66714266368321 10504240 10.1021/bi9910169 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 3265 1735 148 Y72F Lysozyme C Homo sapiens 1.67 110.3 117.3 -3.0 yes 61.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 1LZ1 11.801666816075643 9649316 10.1021/bi980431i 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3282 1735 148 Y72F Lysozyme C Homo sapiens 1.12 117.2 124.16 yes 69.1 glycine 0.05 M DSC Thermal 3.13 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 1LZ1 11.801666816075643 9649316 10.1021/bi980431i 1998 ProTherm 3283 1735 148 Y72F Lysozyme C Homo sapiens 1.34 114.1 120.1 yes 67.0 glycine 0.05 M DSC Thermal 2.99 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 1LZ1 11.801666816075643 9649316 10.1021/bi980431i 1998 ProTherm 3284 1735 148 Y72F Lysozyme C Homo sapiens 1.91 108.1 114.11 yes 64.0 glycine 0.05 M DSC Thermal 2.82 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 1LZ1 11.801666816075643 9649316 10.1021/bi980431i 1998 ProTherm 3285 1735 148 Y72F Lysozyme C Homo sapiens 0.89 105.0 112.2 yes 61.7 glycine 0.05 M DSC Thermal 2.69 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 1LZ1 11.801666816075643 9649316 10.1021/bi980431i 1998 ProTherm 6900 1735 148 Y72F Lysozyme C Homo sapiens 1.67 0.96 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 1LZ1 11.801666816075643 9649316 10.1021/bi980431i 1998 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 3185 1719 148 I74V Lysozyme C Homo sapiens 1.29 71.77 -6.3 yes 42.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 9677301 10.1006/jmbi.1998.1906 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3203 1719 148 I74V Lysozyme C Homo sapiens 74.4 78.2 yes 50.5 glycine 0.05 M DSC Thermal 3.1 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3204 1719 148 I74V Lysozyme C Homo sapiens 69.4 73.0 yes 48.2 glycine 0.05 M DSC Thermal 3.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3205 1719 148 I74V Lysozyme C Homo sapiens 66.7 71.1 yes 45.3 glycine 0.05 M DSC Thermal 2.8 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3206 1719 148 I74V Lysozyme C Homo sapiens 63.6 65.3 -6.6 yes 42.6 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 9677301 10.1006/jmbi.1998.1906 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4017 1719 148 I74V Lysozyme C Homo sapiens 1.34 113.53 117.04 -3.6 yes 61.3 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4032 1719 148 I74V Lysozyme C Homo sapiens yes 64.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 4154 1719 148 I74V Lysozyme C Homo sapiens 1.34 113.6 117.1 -3.6 yes 61.3 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 7473760 10.1006/jmbi.1995.0599 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6883 1719 148 I74V Lysozyme C Homo sapiens 1.34 1.2 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 7473760 10.1006/jmbi.1995.0599 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 6919 1719 148 I74V Lysozyme C Homo sapiens 1.2 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 7739 1719 148 I74V Lysozyme C Homo sapiens 1.29 1.34 yes glycine 0.05 M 49.2 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 9677301 10.1006/jmbi.1998.1906 1998 ProTherm capriotti_S1615_map.csv 3330 1754 148 I74A Lysozyme C Homo sapiens 1.44 98.8 102.2 yes 60.2 glycine 0.05 M DSC Thermal 3.08 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 9398521 10.1006/jmbi.1997.1365 1997 ProTherm 3331 1754 148 I74A Lysozyme C Homo sapiens 1.6 96.9 102.2 yes 58.5 glycine 0.05 M DSC Thermal 2.96 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 9398521 10.1006/jmbi.1997.1365 1997 ProTherm 3332 1754 148 I74A Lysozyme C Homo sapiens 1.46 90.7 92.1 yes 54.2 glycine 0.05 M DSC Thermal 2.81 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 9398521 10.1006/jmbi.1997.1365 1997 ProTherm 3333 1754 148 I74A Lysozyme C Homo sapiens 1.53 89.0 91.4 yes 52.3 glycine 0.05 M DSC Thermal 2.67 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 9398521 10.1006/jmbi.1997.1365 1997 ProTherm 3334 1754 148 I74A Lysozyme C Homo sapiens 1.22 82.8 84.0 yes 48.2 glycine 0.05 M DSC Thermal 2.5 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 9398521 10.1006/jmbi.1997.1365 1997 ProTherm 3357 1754 148 I74A Lysozyme C Homo sapiens 1.34 -12.5 yes 52.4 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 9398521 10.1006/jmbi.1997.1365 1997 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4016 1754 148 I74A Lysozyme C Homo sapiens 1.34 105.16 110.66 -12.5 yes 52.4 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4031 1754 148 I74A Lysozyme C Homo sapiens yes 64.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 6904 1754 148 I74A Lysozyme C Homo sapiens 1.34 3.71 105.3 110.8 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 9398521 10.1006/jmbi.1997.1365 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 6918 1754 148 I74A Lysozyme C Homo sapiens 3.7 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 3350 1757 148 I74G Lysozyme C Homo sapiens yes 62.7 glycine 0.05 M DSC Thermal 2.73 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 9398521 10.1006/jmbi.1997.1365 1997 ProTherm 4015 1757 148 I74G Lysozyme C Homo sapiens -2.7 yes 62.2 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3975 2049 148 I74L Lysozyme C Homo sapiens 1.41 103.01 113.05 yes 61.2 glycine 0.05 M DSC Thermal 2.48 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 3976 2049 148 I74L Lysozyme C Homo sapiens 1.55 104.92 119.02 yes 64.0 glycine 0.05 M DSC Thermal 2.65 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 3977 2049 148 I74L Lysozyme C Homo sapiens 1.27 112.09 125.0 yes 68.7 glycine 0.05 M DSC Thermal 2.96 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 3978 2049 148 I74L Lysozyme C Homo sapiens 1.15 115.92 125.96 yes 70.3 glycine 0.05 M DSC Thermal 3.1 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 4018 2049 148 I74L Lysozyme C Homo sapiens 1.41 107.31 119.24 -0.3 yes 64.6 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4033 2049 148 I74L Lysozyme C Homo sapiens yes 64.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 6920 2049 148 I74L Lysozyme C Homo sapiens 0.1 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm khan_protherm_data_mapped.csv 3979 2050 148 I74M Lysozyme C Homo sapiens 1.39 92.5 103.01 yes 56.3 glycine 0.05 M DSC Thermal 2.54 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 3980 2050 148 I74M Lysozyme C Homo sapiens 1.63 97.28 107.07 yes 59.2 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 3981 2050 148 I74M Lysozyme C Homo sapiens 1.72 101.1 109.94 yes 61.3 glycine 0.05 M DSC Thermal 2.83 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 3982 2050 148 I74M Lysozyme C Homo sapiens 1.43 104.92 113.05 yes 64.2 glycine 0.05 M DSC Thermal 3.02 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 3983 2050 148 I74M Lysozyme C Homo sapiens 1.53 107.07 115.92 yes 65.9 glycine 0.05 M DSC Thermal 3.11 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 4019 2050 148 I74M Lysozyme C Homo sapiens 1.53 105.88 115.08 -5.8 yes 59.1 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4034 2050 148 I74M Lysozyme C Homo sapiens yes 64.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 6921 2050 148 I74M Lysozyme C Homo sapiens 1.77 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm khan_protherm_data_mapped.csv 3984 2051 148 I74F Lysozyme C Homo sapiens 1.89 76.0 79.35 yes 50.8 glycine 0.05 M DSC Thermal 2.75 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 3985 2051 148 I74F Lysozyme C Homo sapiens 1.77 86.04 89.63 yes 56.3 glycine 0.05 M DSC Thermal 3.06 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 4020 2051 148 I74F Lysozyme C Homo sapiens 1.82 101.58 105.81 -15.0 yes 49.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4035 2051 148 I74F Lysozyme C Homo sapiens yes 64.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 6922 2051 148 I74F Lysozyme C Homo sapiens 4.09 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 4021 2058 148 I74T Lysozyme C Homo sapiens 1.08 101.58 108.03 -12.5 yes 52.4 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4036 2058 148 I74T Lysozyme C Homo sapiens yes 64.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 4158 2058 148 I74T Lysozyme C Homo sapiens 1.24 101.67 108.16 -12.5 yes 52.4 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 9010773 10.1093/oxfordjournals.jbchem.a021544 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4159 2058 148 I74T Lysozyme C Homo sapiens 1.15 97.61 103.3 yes 60.52 glycine 0.05 M DSC Thermal 3.11 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 9010773 10.1093/oxfordjournals.jbchem.a021544 1996 ProTherm 4160 2058 148 I74T Lysozyme C Homo sapiens 1.2 93.3 102.2 yes 57.96 glycine 0.05 M DSC Thermal 2.98 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 9010773 10.1093/oxfordjournals.jbchem.a021544 1996 ProTherm 4161 2058 148 I74T Lysozyme C Homo sapiens 1.0 87.8 90.9 yes 51.78 glycine 0.05 M DSC Thermal 2.67 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 9010773 10.1093/oxfordjournals.jbchem.a021544 1996 ProTherm 6887 2058 148 I74T Lysozyme C Homo sapiens 1.24 3.64 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 9010773 10.1093/oxfordjournals.jbchem.a021544 1996 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 6923 2058 148 I74T Lysozyme C Homo sapiens 3.63 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 13912 2058 148 I74T Lysozyme C Homo sapiens 2.7 6.67 7.31 2.96 yes GdnHCl 40 mM 10.0 CD GdnHCl 4.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 12.167500019073486 in pocket 11121116 10.1046/j.1432-1327.2001.01863.x 2001 ProTherm 349 193 148 Q76A Lysozyme C Homo sapiens 97.04 103.01 yes 64.5 Gly-HCl 0.05 M DSC Thermal 2.5 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 12.982222345140245 in tunnel in pocket 11455596 10.1002/prot.1088 2001 ProTherm M47andM8_S2760.csv, EASE-MM_S1676.csv, PON-TStab_dataset.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S499.csv 350 193 148 Q76A Lysozyme C Homo sapiens 103.97 113.05 yes 67.8 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 12.982222345140245 in tunnel in pocket 11455596 10.1002/prot.1088 2001 ProTherm EASE-MM_S1676.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S499.csv 351 193 148 Q76A Lysozyme C Homo sapiens 114.96 123.09 yes 75.1 Gly-HCl 0.05 M DSC Thermal 3.1 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 12.982222345140245 in tunnel in pocket 11455596 10.1002/prot.1088 2001 ProTherm 368 193 148 Q76A Lysozyme C Homo sapiens 1.65 98.23 3.1 yes 68.0 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 12.982222345140245 in tunnel in pocket 11455596 10.1002/prot.1088 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6868 193 148 Q76A Lysozyme C Homo sapiens -0.91 yes Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 12.982222345140245 in tunnel in pocket 11455596 10.1002/prot.1088 2001 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3890 2021 148 Q76G Lysozyme C Homo sapiens 113.05 120.94 yes 68.3 glycine 0.05 M DSC Thermal 2.59 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 12.982222345140245 in tunnel in pocket 10469827 10.1093/protein/12.8.663 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv 3891 2021 148 Q76G Lysozyme C Homo sapiens 119.02 126.91 yes 72.5 glycine 0.05 M DSC Thermal 2.78 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 12.982222345140245 in tunnel in pocket 10469827 10.1093/protein/12.8.663 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv 3892 2021 148 Q76G Lysozyme C Homo sapiens 126.91 135.04 yes 78.7 glycine 0.05 M DSC Thermal 3.15 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 12.982222345140245 in tunnel in pocket 10469827 10.1093/protein/12.8.663 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv 3910 2021 148 Q76G Lysozyme C Homo sapiens 1.34 108.75 5.7 yes 70.6 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 12.982222345140245 in tunnel in pocket 10469827 10.1093/protein/12.8.663 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S1791.csv 3919 2021 148 Q76G Lysozyme C Homo sapiens yes 64.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 12.982222345140245 in tunnel in pocket 10469827 10.1093/protein/12.8.663 1999 ProTherm 4202 2021 148 Q76G Lysozyme C Homo sapiens 5.7 yes 70.6 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 12.982222345140245 in tunnel in pocket 10913274 10.1021/bi9928694 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4206 2021 148 Q76G Lysozyme C Homo sapiens 1.34 108.75 yes 64.9 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 12.982222345140245 in tunnel in pocket 10913274 10.1021/bi9928694 2000 ProTherm 6913 2021 148 Q76G Lysozyme C Homo sapiens -1.86 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 12.982222345140245 in tunnel in pocket 10469827 10.1093/protein/12.8.663 1999 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 6934 2021 148 Q76G Lysozyme C Homo sapiens 1.34 -1.86 108.75 yes glycine-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 12.982222345140245 in tunnel in pocket 10913274 10.1021/bi9928694 2000 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14094 2021 148 Q76G Lysozyme C Homo sapiens 4.26 -2.06 16.4 yes glycine-HCl 40 mM 10.0 CD GdnHCl 4.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 12.982222345140245 in tunnel in pocket 10913274 10.1021/bi9928694 2000 ProTherm 1381 773 148 I77A Lysozyme C Homo sapiens 1.63 -5.8 yes 43.4 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 12646687 10.1093/proeng/gzg001 2003 ProTherm 3335 773 148 I77A Lysozyme C Homo sapiens 1.87 116.0 122.0 yes 66.5 glycine 0.05 M DSC Thermal 3.12 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 9398521 10.1006/jmbi.1997.1365 1997 ProTherm 3336 773 148 I77A Lysozyme C Homo sapiens 1.63 115.1 120.1 yes 64.5 glycine 0.05 M DSC Thermal 2.98 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 9398521 10.1006/jmbi.1997.1365 1997 ProTherm 3337 773 148 I77A Lysozyme C Homo sapiens 1.2 110.0 115.1 yes 61.5 glycine 0.05 M DSC Thermal 2.8 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 9398521 10.1006/jmbi.1997.1365 1997 ProTherm 3338 773 148 I77A Lysozyme C Homo sapiens 1.2 106.2 114.1 yes 59.1 glycine 0.05 M DSC Thermal 2.66 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 9398521 10.1006/jmbi.1997.1365 1997 ProTherm 3339 773 148 I77A Lysozyme C Homo sapiens 0.84 101.2 108.1 yes 55.9 glycine 0.05 M DSC Thermal 2.49 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 9398521 10.1006/jmbi.1997.1365 1997 ProTherm 3358 773 148 I77A Lysozyme C Homo sapiens 1.46 -5.2 yes 59.7 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 9398521 10.1006/jmbi.1997.1365 1997 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4023 773 148 I77A Lysozyme C Homo sapiens 1.46 114.72 120.7 -5.2 yes 59.7 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4038 773 148 I77A Lysozyme C Homo sapiens yes 64.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 6905 773 148 I77A Lysozyme C Homo sapiens 1.46 1.72 114.8 120.9 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 9398521 10.1006/jmbi.1997.1365 1997 ProTherm capriotti_S1615_map.csv 6925 773 148 I77A Lysozyme C Homo sapiens 1.72 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm capriotti_S1615_map.csv 7752 773 148 I77A Lysozyme C Homo sapiens 1.63 1.31 75.76 yes Gly-HCl 0.05 M 49.2 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 12646687 10.1093/proeng/gzg001 2003 ProTherm khan_protherm_data_mapped.csv 7789 773 148 I77A Lysozyme C Homo sapiens 72.66 74.81 yes Gly-HCl 0.05 M 47.2 DSC Thermal 2.9 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 12646687 10.1093/proeng/gzg001 2003 ProTherm 8349 773 148 I77A Lysozyme C Homo sapiens 55.69 58.08 yes Gly-HCl 0.05 M 36.7 DSC Thermal 2.35 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 12646687 10.1093/proeng/gzg001 2003 ProTherm 3186 1720 148 I77V Lysozyme C Homo sapiens 1.67 71.29 -4.4 yes 44.8 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 9677301 10.1006/jmbi.1998.1906 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3207 1720 148 I77V Lysozyme C Homo sapiens 75.4 78.7 yes 52.0 glycine 0.05 M DSC Thermal 3.1 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3208 1720 148 I77V Lysozyme C Homo sapiens 74.2 76.1 yes 50.3 glycine 0.05 M DSC Thermal 3.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3209 1720 148 I77V Lysozyme C Homo sapiens 67.5 71.1 -5.1 yes 46.9 glycine 0.05 M DSC Thermal 2.81 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 9677301 10.1006/jmbi.1998.1906 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3210 1720 148 I77V Lysozyme C Homo sapiens 62.9 67.0 yes 44.3 glycine 0.05 M DSC Thermal 2.68 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 4024 1720 148 I77V Lysozyme C Homo sapiens 1.2 110.18 117.11 -3.4 yes 61.5 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4039 1720 148 I77V Lysozyme C Homo sapiens yes 64.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 4155 1720 148 I77V Lysozyme C Homo sapiens 1.2 110.3 117.3 -3.4 yes 61.5 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 7473760 10.1006/jmbi.1995.0599 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6884 1720 148 I77V Lysozyme C Homo sapiens 1.2 1.1 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 7473760 10.1006/jmbi.1995.0599 1995 ProTherm capriotti_S1615_map.csv 6926 1720 148 I77V Lysozyme C Homo sapiens 1.1 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm capriotti_S1615_map.csv 7740 1720 148 I77V Lysozyme C Homo sapiens 1.67 0.93 yes glycine 0.05 M 49.2 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 9677301 10.1006/jmbi.1998.1906 1998 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 3351 1758 148 I77G Lysozyme C Homo sapiens 0.81 100.2 102.2 yes 60.4 glycine 0.05 M DSC Thermal 3.16 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 9398521 10.1006/jmbi.1997.1365 1997 ProTherm 3352 1758 148 I77G Lysozyme C Homo sapiens 0.86 98.6 100.0 yes 59.2 glycine 0.05 M DSC Thermal 3.02 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 9398521 10.1006/jmbi.1997.1365 1997 ProTherm 3353 1758 148 I77G Lysozyme C Homo sapiens 0.65 94.7 97.6 yes 54.6 glycine 0.05 M DSC Thermal 2.82 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 9398521 10.1006/jmbi.1997.1365 1997 ProTherm 3354 1758 148 I77G Lysozyme C Homo sapiens 0.62 90.9 92.8 yes 52.0 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 9398521 10.1006/jmbi.1997.1365 1997 ProTherm 3355 1758 148 I77G Lysozyme C Homo sapiens 0.79 84.4 89.7 yes 48.1 glycine 0.05 M DSC Thermal 2.49 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 9398521 10.1006/jmbi.1997.1365 1997 ProTherm 3361 1758 148 I77G Lysozyme C Homo sapiens 1.24 -12.7 yes 52.2 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 9398521 10.1006/jmbi.1997.1365 1997 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4022 1758 148 I77G Lysozyme C Homo sapiens 1.24 106.12 109.39 -12.7 yes 52.2 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4037 1758 148 I77G Lysozyme C Homo sapiens yes 64.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 6908 1758 148 I77G Lysozyme C Homo sapiens 1.24 3.83 106.2 109.5 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 9398521 10.1006/jmbi.1997.1365 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 6924 1758 148 I77G Lysozyme C Homo sapiens 3.82 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 3986 2052 148 I77L Lysozyme C Homo sapiens 1.12 108.99 117.11 yes 61.4 glycine 0.05 M DSC Thermal 2.51 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm khan_protherm_data_mapped.csv 3987 2052 148 I77L Lysozyme C Homo sapiens 1.17 113.05 121.89 yes 64.5 glycine 0.05 M DSC Thermal 2.66 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm khan_protherm_data_mapped.csv 3988 2052 148 I77L Lysozyme C Homo sapiens 1.17 115.92 125.96 yes 67.0 glycine 0.05 M DSC Thermal 2.83 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm khan_protherm_data_mapped.csv 3989 2052 148 I77L Lysozyme C Homo sapiens 1.31 119.02 128.11 yes 69.8 glycine 0.05 M DSC Thermal 2.96 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm khan_protherm_data_mapped.csv 3990 2052 148 I77L Lysozyme C Homo sapiens 1.24 123.09 131.93 yes 72.1 glycine 0.05 M DSC Thermal 3.17 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm khan_protherm_data_mapped.csv 4025 2052 148 I77L Lysozyme C Homo sapiens 1.27 113.53 122.08 0.0 yes 64.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm khan_protherm_data_mapped.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4040 2052 148 I77L Lysozyme C Homo sapiens yes 64.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm khan_protherm_data_mapped.csv 6927 2052 148 I77L Lysozyme C Homo sapiens 0.0 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm khan_protherm_data_mapped.csv 3991 2053 148 I77M Lysozyme C Homo sapiens 1.31 96.08 103.97 yes 57.4 glycine 0.05 M DSC Thermal 2.47 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 3992 2053 148 I77M Lysozyme C Homo sapiens 1.0 98.47 108.03 yes 59.9 glycine 0.05 M DSC Thermal 2.65 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 3993 2053 148 I77M Lysozyme C Homo sapiens 1.2 103.01 109.94 yes 62.0 glycine 0.05 M DSC Thermal 2.8 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 3994 2053 148 I77M Lysozyme C Homo sapiens 1.1 106.12 114.01 yes 64.8 glycine 0.05 M DSC Thermal 2.95 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 3995 2053 148 I77M Lysozyme C Homo sapiens 1.15 107.07 117.11 yes 66.5 glycine 0.05 M DSC Thermal 3.13 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 4026 2053 148 I77M Lysozyme C Homo sapiens 1.27 105.64 114.72 -4.2 yes 60.7 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4041 2053 148 I77M Lysozyme C Homo sapiens yes 64.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 6928 2053 148 I77M Lysozyme C Homo sapiens 1.29 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm khan_protherm_data_mapped.csv 3996 2054 148 I77F Lysozyme C Homo sapiens 1.41 99.9 108.03 yes 59.8 glycine 0.05 M DSC Thermal 2.54 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 3997 2054 148 I77F Lysozyme C Homo sapiens 1.58 103.97 112.09 yes 62.8 glycine 0.05 M DSC Thermal 2.73 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 3998 2054 148 I77F Lysozyme C Homo sapiens 1.2 108.03 115.92 yes 65.4 glycine 0.05 M DSC Thermal 2.9 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 3999 2054 148 I77F Lysozyme C Homo sapiens 1.29 110.9 119.98 yes 68.0 glycine 0.05 M DSC Thermal 3.05 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 4000 2054 148 I77F Lysozyme C Homo sapiens 1.36 114.01 123.09 yes 69.8 glycine 0.05 M DSC Thermal 3.15 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 4027 2054 148 I77F Lysozyme C Homo sapiens 1.39 107.07 115.13 -2.6 yes 62.3 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4042 2054 148 I77F Lysozyme C Homo sapiens yes 64.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 6929 2054 148 I77F Lysozyme C Homo sapiens 0.81 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 4001 2055 148 I77S Lysozyme C Homo sapiens 1.27 87.0 92.73 yes 50.2 glycine 0.05 M DSC Thermal 2.51 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 4002 2055 148 I77S Lysozyme C Homo sapiens 1.2 90.82 96.8 yes 53.1 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 4003 2055 148 I77S Lysozyme C Homo sapiens 1.55 94.65 99.9 yes 55.3 glycine 0.05 M DSC Thermal 2.84 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 4004 2055 148 I77S Lysozyme C Homo sapiens 1.48 98.23 103.97 yes 58.2 glycine 0.05 M DSC Thermal 3.04 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 4005 2055 148 I77S Lysozyme C Homo sapiens 1.24 99.9 106.12 yes 60.0 glycine 0.05 M DSC Thermal 3.17 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 4028 2055 148 I77S Lysozyme C Homo sapiens 1.34 106.84 113.65 -11.8 yes 53.1 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4043 2055 148 I77S Lysozyme C Homo sapiens yes 64.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 6930 2055 148 I77S Lysozyme C Homo sapiens 3.59 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm khan_protherm_data_mapped.csv 4006 2056 148 I77T Lysozyme C Homo sapiens 1.65 90.34 98.71 yes 52.9 glycine 0.05 M DSC Thermal 2.4 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 4007 2056 148 I77T Lysozyme C Homo sapiens 1.67 103.97 104.92 yes 56.9 glycine 0.05 M DSC Thermal 2.62 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 4008 2056 148 I77T Lysozyme C Homo sapiens 1.27 106.12 109.94 yes 59.5 glycine 0.05 M DSC Thermal 2.79 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 4009 2056 148 I77T Lysozyme C Homo sapiens 1.17 106.12 109.94 yes 59.5 glycine 0.05 M DSC Thermal 2.8 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 4010 2056 148 I77T Lysozyme C Homo sapiens 1.39 107.07 107.07 yes 62.9 glycine 0.05 M DSC Thermal 2.99 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 4011 2056 148 I77T Lysozyme C Homo sapiens 1.2 110.9 119.02 yes 64.9 glycine 0.05 M DSC Thermal 3.15 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 4029 2056 148 I77T Lysozyme C Homo sapiens 1.53 112.33 118.24 -6.9 yes 58.0 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4044 2056 148 I77T Lysozyme C Homo sapiens yes 64.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 6931 2056 148 I77T Lysozyme C Homo sapiens 2.22 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm khan_protherm_data_mapped.csv 4012 2057 148 I77Y Lysozyme C Homo sapiens 1.55 79.35 84.37 yes 51.4 glycine 0.05 M DSC Thermal 2.71 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 4013 2057 148 I77Y Lysozyme C Homo sapiens 1.17 82.7 88.67 yes 54.2 glycine 0.05 M DSC Thermal 2.89 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 4014 2057 148 I77Y Lysozyme C Homo sapiens 1.27 90.58 97.04 yes 59.5 glycine 0.05 M DSC Thermal 3.18 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 4030 2057 148 I77Y Lysozyme C Homo sapiens 1.34 97.75 105.11 -13.8 yes 51.1 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4045 2057 148 I77Y Lysozyme C Homo sapiens yes 64.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm 6932 2057 148 I77Y Lysozyme C Homo sapiens 3.78 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 13.046249985694885 in tunnel in pocket 10556244 10.1093/protein/12.10.841 1999 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3648 1891 148 S79A Lysozyme C Homo sapiens 1.31 113.05 118.07 yes 68.3 glycine 0.05 M DSC Thermal 3.1 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 13.820000012715658 10350481 10.1021/bi9901228 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 3649 1891 148 S79A Lysozyme C Homo sapiens 1.15 107.07 110.9 yes 63.6 glycine 0.05 M DSC Thermal 2.84 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 13.820000012715658 10350481 10.1021/bi9901228 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 3650 1891 148 S79A Lysozyme C Homo sapiens 1.34 102.06 106.12 yes 60.7 glycine 0.05 M DSC Thermal 2.71 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 13.820000012715658 10350481 10.1021/bi9901228 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, Broom_S605.csv 3651 1891 148 S79A Lysozyme C Homo sapiens 1.1 98.95 103.01 yes 57.0 glycine 0.05 M DSC Thermal 2.51 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 13.820000012715658 10350481 10.1021/bi9901228 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 3663 1891 148 S79A Lysozyme C Homo sapiens 1.27 108.51 -4.3 yes 60.6 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 13.820000012715658 10350481 10.1021/bi9901228 1999 ProTherm AUTOMUTE_S1962.csv, Broom_S605.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3266 1736 148 Y81F Lysozyme C Homo sapiens 1.53 110.8 116.6 -0.7 yes 64.2 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 39.912500063578285 in tunnel in pocket 9649316 10.1021/bi980431i 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3286 1736 148 Y81F Lysozyme C Homo sapiens 0.67 123.2 129.19 yes 72.7 glycine 0.05 M DSC Thermal 3.17 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 39.912500063578285 in tunnel in pocket 9649316 10.1021/bi980431i 1998 ProTherm 3287 1736 148 Y81F Lysozyme C Homo sapiens 0.6 117.2 122.0 yes 69.5 glycine 0.05 M DSC Thermal 3.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 39.912500063578285 in tunnel in pocket 9649316 10.1021/bi980431i 1998 ProTherm 3288 1736 148 Y81F Lysozyme C Homo sapiens 1.17 111.0 116.03 yes 65.0 glycine 0.05 M DSC Thermal 2.73 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 39.912500063578285 in tunnel in pocket 9649316 10.1021/bi980431i 1998 ProTherm 3289 1736 148 Y81F Lysozyme C Homo sapiens 1.53 106.2 112.2 yes 61.9 glycine 0.05 M DSC Thermal 2.58 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 39.912500063578285 in tunnel in pocket 9649316 10.1021/bi980431i 1998 ProTherm 6901 1736 148 Y81F Lysozyme C Homo sapiens 1.53 0.24 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 39.912500063578285 in tunnel in pocket 9649316 10.1021/bi980431i 1998 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 15599 7276 148 W82C, C83A Lysozyme C Homo sapiens 3.79 2.2 12.5 3.3 yes Sodium acetate 20 mM 20.0 CD GdnHCl 5.2 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0, 9.0 1LZ1 15.115714209420341, 13.204999923706055 in tunnel in pocket 10727242 10.1021/bi9921945 2000 ProTherm 47 47 148 D85N Lysozyme C Homo sapiens -0.7 yes 56.8 glycine hydrochloride 0.05 M DSC Thermal 2.2 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 12.585000157356262 11015217 10.1021/bi000849s 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 53 47 148 D85N Lysozyme C Homo sapiens -6.1 yes 74.0 sodium acetate 0.02 M DSC Thermal 4.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 12.585000157356262 11015217 10.1021/bi000849s 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 57 47 148 D85N Lysozyme C Homo sapiens -1.0 yes 55.2 glycine hydrochloride 0.05 M KCl 0.2 M DSC Thermal 2.3 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 12.585000157356262 11015217 10.1021/bi000849s 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 61 47 148 D85N Lysozyme C Homo sapiens -5.2 yes 72.5 sodium acetate 0.02 M KCl 0.2 M DSC Thermal 4.5 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 12.585000157356262 11015217 10.1021/bi000849s 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6840 47 148 D85N Lysozyme C Homo sapiens 2.25 3.18 yes sodium acetate 0.02 M 65.0 DSC Thermal 4.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 12.585000157356262 11015217 10.1021/bi000849s 2000 ProTherm 6844 47 148 D85N Lysozyme C Homo sapiens 1.7 2.37 yes sodium acetate 0.02 M 65.0 KCl 0.2 M DSC Thermal 4.5 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 12.585000157356262 11015217 10.1021/bi000849s 2000 ProTherm 13913 6475 148 D85H Lysozyme C Homo sapiens 3.1 4.54 9.44 3.2 yes GdnHCl 40 mM 10.0 CD GdnHCl 4.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 12.585000157356262 11121116 10.1046/j.1432-1327.2001.01863.x 2001 ProTherm 514 292 148 G86A Lysozyme C Homo sapiens 103.01 yes 62.8 Gly-HCl 0.05 M DSC Thermal 2.6 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 16.329999923706055 11599030 10.1002/prot.1147 2001 ProTherm 515 292 148 G86A Lysozyme C Homo sapiens 108.99 yes 64.9 Gly-HCl 0.05 M DSC Thermal 2.72 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 16.329999923706055 11599030 10.1002/prot.1147 2001 ProTherm M47andM8_S2760.csv 516 292 148 G86A Lysozyme C Homo sapiens 114.01 yes 69.2 Gly-HCl 0.05 M DSC Thermal 3.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 16.329999923706055 11599030 10.1002/prot.1147 2001 ProTherm 534 292 148 G86A Lysozyme C Homo sapiens 1.65 107.55 -0.4 yes 64.5 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 16.329999923706055 11599030 10.1002/prot.1147 2001 ProTherm 6877 292 148 G86A Lysozyme C Homo sapiens 1.65 0.12 yes Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 16.329999923706055 11599030 10.1002/prot.1147 2001 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3731 1941 148 T88A Lysozyme C Homo sapiens 109.94 113.05 yes 67.1 glycine-HCl 0.05 M DSC Thermal 3.1 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 18.277142797197616 10504240 10.1021/bi9910169 1999 ProTherm STRUM_Q3421.csv 3732 1941 148 T88A Lysozyme C Homo sapiens 107.07 109.94 yes 64.7 glycine-HCl 0.05 M DSC Thermal 3.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 18.277142797197616 10504240 10.1021/bi9910169 1999 ProTherm STRUM_Q3421.csv 3733 1941 148 T88A Lysozyme C Homo sapiens 103.01 106.12 yes 62.2 glycine-HCl 0.05 M DSC Thermal 2.85 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 18.277142797197616 10504240 10.1021/bi9910169 1999 ProTherm STRUM_Q3421.csv 3734 1941 148 T88A Lysozyme C Homo sapiens 101.1 103.97 yes 60.0 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 18.277142797197616 10504240 10.1021/bi9910169 1999 ProTherm STRUM_Q3421.csv 3735 1941 148 T88A Lysozyme C Homo sapiens 98.47 99.9 yes 57.3 glycine-HCl 0.05 M DSC Thermal 2.5 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 18.277142797197616 10504240 10.1021/bi9910169 1999 ProTherm STRUM_Q3421.csv 3754 1946 148 T88V Lysozyme C Homo sapiens 119.02 123.09 yes 70.3 glycine-HCl 0.05 M DSC Thermal 3.1 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 18.277142797197616 10504240 10.1021/bi9910169 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 3755 1946 148 T88V Lysozyme C Homo sapiens 114.96 120.94 yes 67.6 glycine-HCl 0.05 M DSC Thermal 3.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 18.277142797197616 10504240 10.1021/bi9910169 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 3756 1946 148 T88V Lysozyme C Homo sapiens 112.09 117.11 yes 65.3 glycine-HCl 0.05 M DSC Thermal 2.85 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 18.277142797197616 10504240 10.1021/bi9910169 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 3757 1946 148 T88V Lysozyme C Homo sapiens 107.07 110.9 yes 62.6 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 18.277142797197616 10504240 10.1021/bi9910169 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv 3758 1946 148 T88V Lysozyme C Homo sapiens 102.06 106.12 yes 59.5 glycine-HCl 0.05 M DSC Thermal 2.5 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 18.277142797197616 10504240 10.1021/bi9910169 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, HotMuSiC_S1626.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 1048 631 148 P89G Lysozyme C Homo sapiens 1.58 -4.7 yes 64.1 glycine-HCl 50 mM DSC Thermal 2.8 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1.0 1LZ1 29.662857055664062 1643041 10.1021/bi00146a008 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6701 631 148 P89G Lysozyme C Homo sapiens 1.58 1.6 120.7 yes glycine-HCl 50 mM 68.8 DSC Thermal 2.8 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1.0 1LZ1 29.662857055664062 1643041 10.1021/bi00146a008 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 9879 631 148 P89G Lysozyme C Homo sapiens 2.63 1.2 8.5 5.43 yes (100%) glycine-HCl 40 mM 25.0 CD GdnHCl 3.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1.0 1LZ1 29.662857055664062 1911779 10.1021/bi00105a011 1991 ProTherm 14594 6797 148 P89G, P121G Lysozyme C Homo sapiens 1.58 -4.5 yes 64.3 glycine-HCl 50 mM DSC Thermal 2.8 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1.0, 5.0 1LZ1 29.662857055664062, 60.60857173374721 1643041 10.1021/bi00146a008 1992 ProTherm 14885 6797 148 P89G, P121G Lysozyme C Homo sapiens 1.58 1.6 120.5 yes glycine-HCl 50 mM 68.8 DSC Thermal 2.8 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1.0, 5.0 1LZ1 29.662857055664062, 60.60857173374721 1643041 10.1021/bi00146a008 1992 ProTherm 15245 6797 148 P89G, P121G Lysozyme C Homo sapiens 2.64 1.1 8.6 5.48 yes (100%) glycine-HCl 40 mM 25.0 CD GdnHCl 3.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1.0, 5.0 1LZ1 29.662857055664062, 60.60857173374721 1911779 10.1021/bi00105a011 1991 ProTherm 517 293 148 G90A Lysozyme C Homo sapiens 99.9 yes 58.2 Gly-HCl 0.05 M DSC Thermal 2.38 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 2.0 1LZ1 54.83749961853027 11599030 10.1002/prot.1147 2001 ProTherm 518 293 148 G90A Lysozyme C Homo sapiens 106.12 yes 62.6 Gly-HCl 0.05 M DSC Thermal 2.64 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 2.0 1LZ1 54.83749961853027 11599030 10.1002/prot.1147 2001 ProTherm 519 293 148 G90A Lysozyme C Homo sapiens 119.98 yes 72.2 Gly-HCl 0.05 M DSC Thermal 3.16 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 2.0 1LZ1 54.83749961853027 11599030 10.1002/prot.1147 2001 ProTherm 535 293 148 G90A Lysozyme C Homo sapiens 1.43 109.46 -1.1 yes 63.8 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 2.0 1LZ1 54.83749961853027 11599030 10.1002/prot.1147 2001 ProTherm 6878 293 148 G90A Lysozyme C Homo sapiens 1.43 0.36 yes Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 2.0 1LZ1 54.83749961853027 11599030 10.1002/prot.1147 2001 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1121 675 148 V92G Lysozyme C Homo sapiens 108.03 yes 61.28 glycine-HCl 0.05 M DSC Thermal 2.53 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11087397 10.1021/bi0015717 2000 ProTherm 1122 675 148 V92G Lysozyme C Homo sapiens 114.96 yes 65.5 glycine-HCl 0.05 M DSC Thermal 2.78 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11087397 10.1021/bi0015717 2000 ProTherm 1123 675 148 V92G Lysozyme C Homo sapiens 120.94 yes 68.71 glycine-HCl 0.05 M DSC Thermal 2.95 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11087397 10.1021/bi0015717 2000 ProTherm 1124 675 148 V92G Lysozyme C Homo sapiens 124.04 yes 70.82 glycine-HCl 0.05 M DSC Thermal 3.09 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11087397 10.1021/bi0015717 2000 ProTherm 1125 675 148 V92G Lysozyme C Homo sapiens 129.06 yes 74.04 glycine-HCl 0.05 M DSC Thermal 3.3 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11087397 10.1021/bi0015717 2000 ProTherm 1171 675 148 V92G Lysozyme C Homo sapiens 1.48 114.01 -0.7 yes 64.2 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11087397 10.1021/bi0015717 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 1186 675 148 V92G Lysozyme C Homo sapiens yes 64.9 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11087397 10.1021/bi0015717 2000 ProTherm 6944 675 148 V92G Lysozyme C Homo sapiens 0.22 yes glycine-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11087397 10.1021/bi0015717 2000 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1126 676 148 V92I Lysozyme C Homo sapiens 89.87 yes 66.07 glycine-HCl 0.05 M DSC Thermal 2.67 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11087397 10.1021/bi0015717 2000 ProTherm 1127 676 148 V92I Lysozyme C Homo sapiens 92.5 yes 68.29 glycine-HCl 0.05 M DSC Thermal 2.8 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11087397 10.1021/bi0015717 2000 ProTherm 1128 676 148 V92I Lysozyme C Homo sapiens 96.56 yes 71.67 glycine-HCl 0.05 M DSC Thermal 3.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11087397 10.1021/bi0015717 2000 ProTherm 1172 676 148 V92I Lysozyme C Homo sapiens 1.2 88.43 1.7 yes 66.6 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11087397 10.1021/bi0015717 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 1187 676 148 V92I Lysozyme C Homo sapiens yes 64.9 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11087397 10.1021/bi0015717 2000 ProTherm 6945 676 148 V92I Lysozyme C Homo sapiens -0.45 yes glycine-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11087397 10.1021/bi0015717 2000 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1129 677 148 V92L Lysozyme C Homo sapiens 100.14 yes 62.35 glycine-HCl 0.05 M DSC Thermal 2.5 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11087397 10.1021/bi0015717 2000 ProTherm 1130 677 148 V92L Lysozyme C Homo sapiens 103.97 yes 65.28 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11087397 10.1021/bi0015717 2000 ProTherm 1131 677 148 V92L Lysozyme C Homo sapiens 107.07 yes 67.51 glycine-HCl 0.05 M DSC Thermal 2.83 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11087397 10.1021/bi0015717 2000 ProTherm 1132 677 148 V92L Lysozyme C Homo sapiens 112.09 yes 71.61 glycine-HCl 0.05 M DSC Thermal 3.05 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11087397 10.1021/bi0015717 2000 ProTherm 1133 677 148 V92L Lysozyme C Homo sapiens 114.01 yes 73.32 glycine-HCl 0.05 M DSC Thermal 3.15 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11087397 10.1021/bi0015717 2000 ProTherm 1173 677 148 V92L Lysozyme C Homo sapiens 1.27 103.49 0.6 yes 65.5 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11087397 10.1021/bi0015717 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 1188 677 148 V92L Lysozyme C Homo sapiens yes 64.9 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11087397 10.1021/bi0015717 2000 ProTherm 6946 677 148 V92L Lysozyme C Homo sapiens -0.19 yes glycine-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11087397 10.1021/bi0015717 2000 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1134 678 148 V92M Lysozyme C Homo sapiens 107.07 yes 63.42 glycine-HCl 0.05 M DSC Thermal 2.5 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11087397 10.1021/bi0015717 2000 ProTherm HotMuSiC_S1626.csv 1135 678 148 V92M Lysozyme C Homo sapiens 113.05 yes 66.86 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11087397 10.1021/bi0015717 2000 ProTherm 1136 678 148 V92M Lysozyme C Homo sapiens 117.11 yes 69.38 glycine-HCl 0.05 M DSC Thermal 2.83 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11087397 10.1021/bi0015717 2000 ProTherm 1137 678 148 V92M Lysozyme C Homo sapiens 123.09 yes 73.23 glycine-HCl 0.05 M DSC Thermal 3.1 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11087397 10.1021/bi0015717 2000 ProTherm 1138 678 148 V92M Lysozyme C Homo sapiens 125.0 yes 74.95 glycine-HCl 0.05 M DSC Thermal 3.2 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11087397 10.1021/bi0015717 2000 ProTherm 1174 678 148 V92M Lysozyme C Homo sapiens 1.58 109.46 2.0 yes 66.9 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11087397 10.1021/bi0015717 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 1189 678 148 V92M Lysozyme C Homo sapiens yes 64.9 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11087397 10.1021/bi0015717 2000 ProTherm 6947 678 148 V92M Lysozyme C Homo sapiens -0.65 yes glycine-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11087397 10.1021/bi0015717 2000 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1139 679 148 V92F Lysozyme C Homo sapiens 108.03 yes 63.65 glycine-HCl 0.05 M DSC Thermal 2.68 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11087397 10.1021/bi0015717 2000 ProTherm 1140 679 148 V92F Lysozyme C Homo sapiens 112.09 yes 66.32 glycine-HCl 0.05 M DSC Thermal 2.84 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11087397 10.1021/bi0015717 2000 ProTherm 1141 679 148 V92F Lysozyme C Homo sapiens 117.11 yes 70.5 glycine-HCl 0.05 M DSC Thermal 3.1 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11087397 10.1021/bi0015717 2000 ProTherm 1142 679 148 V92F Lysozyme C Homo sapiens 119.98 yes 72.44 glycine-HCl 0.05 M DSC Thermal 3.23 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11087397 10.1021/bi0015717 2000 ProTherm 1143 679 148 V92F Lysozyme C Homo sapiens 124.04 yes 75.6 glycine-HCl 0.05 M DSC Thermal 3.4 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11087397 10.1021/bi0015717 2000 ProTherm 1175 679 148 V92F Lysozyme C Homo sapiens 1.34 109.7 -0.9 yes 64.0 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11087397 10.1021/bi0015717 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 1190 679 148 V92F Lysozyme C Homo sapiens yes 64.9 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11087397 10.1021/bi0015717 2000 ProTherm 6948 679 148 V92F Lysozyme C Homo sapiens 0.29 yes glycine-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11087397 10.1021/bi0015717 2000 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1278 723 148 V92S Lysozyme C Homo sapiens 104.92 109.94 Unknown 62.1 Gly-HCl 0.05 M DSC Thermal 2.61 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv 1279 723 148 V92S Lysozyme C Homo sapiens 108.99 114.96 Unknown 66.0 Gly-HCl 0.05 M DSC Thermal 2.83 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv 1280 723 148 V92S Lysozyme C Homo sapiens 117.11 121.89 Unknown 72.2 Gly-HCl 0.05 M DSC Thermal 3.28 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11927576 10.1074/jbc.M110728200 2002 ProTherm 1322 723 148 V92S Lysozyme C Homo sapiens 1.22 108.03 0.0 Unknown 64.9 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3893 723 148 V92S Lysozyme C Homo sapiens 104.92 109.94 yes 62.1 glycine 0.05 M DSC Thermal 2.61 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 10469827 10.1093/protein/12.8.663 1999 ProTherm 3894 723 148 V92S Lysozyme C Homo sapiens 108.99 114.96 yes 66.0 glycine 0.05 M DSC Thermal 2.83 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 10469827 10.1093/protein/12.8.663 1999 ProTherm 3895 723 148 V92S Lysozyme C Homo sapiens 117.11 121.89 yes 72.2 glycine 0.05 M DSC Thermal 3.28 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 10469827 10.1093/protein/12.8.663 1999 ProTherm 3911 723 148 V92S Lysozyme C Homo sapiens 1.22 108.03 -1.2 yes 63.7 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 10469827 10.1093/protein/12.8.663 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3920 723 148 V92S Lysozyme C Homo sapiens yes 64.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 10469827 10.1093/protein/12.8.663 1999 ProTherm 6914 723 148 V92S Lysozyme C Homo sapiens 0.38 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 10469827 10.1093/protein/12.8.663 1999 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 6959 723 148 V92S Lysozyme C Homo sapiens 1.22 0.38 108.03 Unknown Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11927576 10.1074/jbc.M110728200 2002 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1281 724 148 V92Y Lysozyme C Homo sapiens 103.97 103.97 Unknown 63.3 Gly-HCl 0.05 M DSC Thermal 2.67 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv 1282 724 148 V92Y Lysozyme C Homo sapiens 110.18 111.14 Unknown 66.9 Gly-HCl 0.05 M DSC Thermal 2.82 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11927576 10.1074/jbc.M110728200 2002 ProTherm 1283 724 148 V92Y Lysozyme C Homo sapiens 114.96 116.16 Unknown 70.0 Gly-HCl 0.05 M DSC Thermal 3.02 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11927576 10.1074/jbc.M110728200 2002 ProTherm 1284 724 148 V92Y Lysozyme C Homo sapiens 119.98 119.98 Unknown 73.3 Gly-HCl 0.05 M DSC Thermal 3.21 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11927576 10.1074/jbc.M110728200 2002 ProTherm 1285 724 148 V92Y Lysozyme C Homo sapiens 122.13 123.09 Unknown 74.1 Gly-HCl 0.05 M DSC Thermal 3.26 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11927576 10.1074/jbc.M110728200 2002 ProTherm 1323 724 148 V92Y Lysozyme C Homo sapiens -0.9 Unknown 64.0 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6960 724 148 V92Y Lysozyme C Homo sapiens 1.65 0.24 106.6 Unknown Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11927576 10.1074/jbc.M110728200 2002 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1286 725 148 V92D Lysozyme C Homo sapiens 103.01 109.94 Unknown 61.7 Gly-HCl 0.05 M DSC Thermal 2.6 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11927576 10.1074/jbc.M110728200 2002 ProTherm 1287 725 148 V92D Lysozyme C Homo sapiens 107.07 114.96 Unknown 65.9 Gly-HCl 0.05 M DSC Thermal 2.83 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv 1288 725 148 V92D Lysozyme C Homo sapiens 112.09 118.07 Unknown 68.1 Gly-HCl 0.05 M DSC Thermal 2.98 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv 1289 725 148 V92D Lysozyme C Homo sapiens 114.96 123.09 Unknown 70.1 Gly-HCl 0.05 M DSC Thermal 3.1 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv 1290 725 148 V92D Lysozyme C Homo sapiens 119.98 126.91 Unknown 72.5 Gly-HCl 0.05 M DSC Thermal 3.25 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv 1324 725 148 V92D Lysozyme C Homo sapiens -1.4 Unknown 63.5 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6961 725 148 V92D Lysozyme C Homo sapiens 1.58 0.43 106.84 Unknown Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11927576 10.1074/jbc.M110728200 2002 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1291 726 148 V92N Lysozyme C Homo sapiens 109.94 114.01 Unknown 63.0 Gly-HCl 0.05 M DSC Thermal 2.65 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv 1292 726 148 V92N Lysozyme C Homo sapiens 114.01 115.92 Unknown 66.2 Gly-HCl 0.05 M DSC Thermal 2.84 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv 1293 726 148 V92N Lysozyme C Homo sapiens 120.94 123.09 Unknown 71.5 Gly-HCl 0.05 M DSC Thermal 3.18 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv 1325 726 148 V92N Lysozyme C Homo sapiens -1.0 Unknown 63.9 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6962 726 148 V92N Lysozyme C Homo sapiens 1.1 0.33 115.44 Unknown Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11927576 10.1074/jbc.M110728200 2002 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1294 727 148 V92R Lysozyme C Homo sapiens 102.06 100.14 Unknown 63.8 Gly-HCl 0.05 M DSC Thermal 2.66 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv 1295 727 148 V92R Lysozyme C Homo sapiens 108.03 105.16 Unknown 67.3 Gly-HCl 0.05 M DSC Thermal 2.85 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv 1296 727 148 V92R Lysozyme C Homo sapiens 112.09 108.99 Unknown 69.5 Gly-HCl 0.05 M DSC Thermal 3.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv 1297 727 148 V92R Lysozyme C Homo sapiens 117.11 114.01 Unknown 72.8 Gly-HCl 0.05 M DSC Thermal 3.18 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv 1298 727 148 V92R Lysozyme C Homo sapiens 118.07 116.16 Unknown 73.2 Gly-HCl 0.05 M DSC Thermal 3.22 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv 1326 727 148 V92R Lysozyme C Homo sapiens -0.3 Unknown 64.6 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6963 727 148 V92R Lysozyme C Homo sapiens 1.67 0.07 103.97 Unknown Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 11927576 10.1074/jbc.M110728200 2002 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3190 1724 148 V92A Lysozyme C Homo sapiens 1.53 73.68 -1.9 yes 47.3 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 9677301 10.1006/jmbi.1998.1906 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3223 1724 148 V92A Lysozyme C Homo sapiens 82.5 86.4 yes 54.8 glycine 0.05 M DSC Thermal 3.16 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3224 1724 148 V92A Lysozyme C Homo sapiens 79.2 86.4 yes 52.8 glycine 0.05 M DSC Thermal 3.03 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3225 1724 148 V92A Lysozyme C Homo sapiens 74.4 80.9 yes 50.1 glycine 0.05 M DSC Thermal 2.85 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3226 1724 148 V92A Lysozyme C Homo sapiens 71.5 75.6 yes 47.5 glycine 0.05 M DSC Thermal 2.69 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3227 1724 148 V92A Lysozyme C Homo sapiens 65.6 69.9 yes 43.9 glycine 0.05 M DSC Thermal 2.51 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 4166 1724 148 V92A Lysozyme C Homo sapiens 1.48 113.9 119.8 -1.1 yes 63.8 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 9020766 10.1021/bi9621829 1997 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6889 1724 148 V92A Lysozyme C Homo sapiens 1.48 0.36 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 9020766 10.1021/bi9621829 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 7744 1724 148 V92A Lysozyme C Homo sapiens 1.53 0.43 yes glycine 0.05 M 49.2 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 46.39571462358747 9677301 10.1006/jmbi.1998.1906 1998 ProTherm capriotti_S1615_map.csv 7164 3555 148 C95A Lysozyme C Homo sapiens 4.6 0.0 94.8 yes glycine-HCl 0.05 M 57.0 DSC Thermal 3.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 1LZ1 14.90499989191691 in pocket 1525170 10.1021/bi00150a028 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14459 6709 148 C95A, C113A Lysozyme C Homo sapiens -14.5 yes 56.9 glycine-HCl 0.05 M DSC Thermal 3.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0, 9.0 1LZ1 14.90499989191691, 10.931666692097982 in pocket 1525170 10.1021/bi00150a028 1992 ProTherm 14971 6709 148 C95A, C113A Lysozyme C Homo sapiens 4.6 0.0 90.8 yes glycine-HCl 0.05 M 57.0 DSC Thermal 3.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0, 9.0 1LZ1 14.90499989191691, 10.931666692097982 in pocket 1525170 10.1021/bi00150a028 1992 ProTherm 15619 6709 148 C95A, C113A Lysozyme C Homo sapiens 5.8 8.2 yes glycine-HCl 40 mM 10.0 CD GdnHCl 4.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0, 9.0 1LZ1 14.90499989191691, 10.931666692097982 in pocket 1537844 1992 ProTherm 15620 6709 148 C95A, C113A Lysozyme C Homo sapiens 5.7 6.1 yes glycine-HCl 40 mM 10.0 Fluorescence GdnHCl 3.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0, 9.0 1LZ1 14.90499989191691, 10.931666692097982 in pocket 1537844 1992 ProTherm 352 194 148 H96A Lysozyme C Homo sapiens 97.51 107.07 yes 61.1 Gly-HCl 0.05 M DSC Thermal 2.5 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 34.32999973297119 in pocket 11455596 10.1002/prot.1088 2001 ProTherm 353 194 148 H96A Lysozyme C Homo sapiens 103.01 112.09 yes 64.3 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 34.32999973297119 in pocket 11455596 10.1002/prot.1088 2001 ProTherm 354 194 148 H96A Lysozyme C Homo sapiens 109.94 117.11 yes 69.5 Gly-HCl 0.05 M DSC Thermal 3.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 34.32999973297119 in pocket 11455596 10.1002/prot.1088 2001 ProTherm EASE-MM_S1676.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, SVM-WIN31_SVM-3D12_S499.csv 355 194 148 H96A Lysozyme C Homo sapiens 114.96 124.04 yes 72.4 Gly-HCl 0.05 M DSC Thermal 3.23 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 34.32999973297119 in pocket 11455596 10.1002/prot.1088 2001 ProTherm 369 194 148 H96A Lysozyme C Homo sapiens 1.51 103.49 -0.5 yes 64.4 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 34.32999973297119 in pocket 11455596 10.1002/prot.1088 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6869 194 148 H96A Lysozyme C Homo sapiens 0.14 yes Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 34.32999973297119 in pocket 11455596 10.1002/prot.1088 2001 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3896 2022 148 H96G Lysozyme C Homo sapiens 103.01 108.03 yes 61.5 glycine 0.05 M DSC Thermal 2.53 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 34.32999973297119 in pocket 10469827 10.1093/protein/12.8.663 1999 ProTherm 3897 2022 148 H96G Lysozyme C Homo sapiens 109.94 112.09 yes 65.2 glycine 0.05 M DSC Thermal 2.75 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 34.32999973297119 in pocket 10469827 10.1093/protein/12.8.663 1999 ProTherm 3898 2022 148 H96G Lysozyme C Homo sapiens 118.07 119.98 yes 71.0 glycine 0.05 M DSC Thermal 3.1 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 34.32999973297119 in pocket 10469827 10.1093/protein/12.8.663 1999 ProTherm 3912 2022 148 H96G Lysozyme C Homo sapiens 1.58 108.75 -0.5 yes 64.4 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 34.32999973297119 in pocket 10469827 10.1093/protein/12.8.663 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3921 2022 148 H96G Lysozyme C Homo sapiens yes 64.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 34.32999973297119 in pocket 10469827 10.1093/protein/12.8.663 1999 ProTherm 4203 2022 148 H96G Lysozyme C Homo sapiens -0.5 yes 64.4 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 34.32999973297119 in pocket 10913274 10.1021/bi9928694 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4207 2022 148 H96G Lysozyme C Homo sapiens 1.58 108.75 yes 64.9 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 34.32999973297119 in pocket 10913274 10.1021/bi9928694 2000 ProTherm 6915 2022 148 H96G Lysozyme C Homo sapiens 0.12 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 34.32999973297119 in pocket 10469827 10.1093/protein/12.8.663 1999 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 6935 2022 148 H96G Lysozyme C Homo sapiens 1.58 0.12 108.75 yes glycine-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 34.32999973297119 in pocket 10913274 10.1021/bi9928694 2000 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14095 2022 148 H96G Lysozyme C Homo sapiens 3.81 0.53 13.81 yes glycine-HCl 40 mM 10.0 CD GdnHCl 4.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 34.32999973297119 in pocket 10913274 10.1021/bi9928694 2000 ProTherm 3652 1892 148 S98A Lysozyme C Homo sapiens 1.39 129.06 135.04 yes 73.6 glycine 0.05 M DSC Thermal 3.11 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 13.389999866485596 10350481 10.1021/bi9901228 1999 ProTherm AUTOMUTE_S1925.csv, AUTOMUTE_S1962.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, Broom_S605.csv 3653 1892 148 S98A Lysozyme C Homo sapiens 1.34 121.89 129.06 yes 69.1 glycine 0.05 M DSC Thermal 2.85 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 13.389999866485596 10350481 10.1021/bi9901228 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 3654 1892 148 S98A Lysozyme C Homo sapiens 1.34 119.02 125.96 yes 66.2 glycine 0.05 M DSC Thermal 2.69 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 13.389999866485596 10350481 10.1021/bi9901228 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 3655 1892 148 S98A Lysozyme C Homo sapiens 1.41 113.05 119.98 yes 62.7 glycine 0.05 M DSC Thermal 2.5 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 13.389999866485596 10350481 10.1021/bi9901228 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 3664 1892 148 S98A Lysozyme C Homo sapiens 1.43 116.4 1.4 yes 66.3 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 13.389999866485596 10350481 10.1021/bi9901228 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3656 1893 148 S100A Lysozyme C Homo sapiens 1.41 125.0 132.89 yes 73.5 glycine 0.05 M DSC Thermal 3.12 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 13.989999930063883 10350481 10.1021/bi9901228 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, Broom_S605.csv 3657 1893 148 S100A Lysozyme C Homo sapiens 1.2 119.98 128.11 yes 68.9 glycine 0.05 M DSC Thermal 2.85 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 13.989999930063883 10350481 10.1021/bi9901228 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 3658 1893 148 S100A Lysozyme C Homo sapiens 1.27 115.92 123.09 yes 66.0 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 13.989999930063883 10350481 10.1021/bi9901228 1999 ProTherm AUTOMUTE_S1925.csv, AUTOMUTE_S1962.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 3659 1893 148 S100A Lysozyme C Homo sapiens 1.41 110.9 117.11 yes 62.5 glycine 0.05 M DSC Thermal 2.51 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 13.989999930063883 10350481 10.1021/bi9901228 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 3665 1893 148 S100A Lysozyme C Homo sapiens 1.27 114.48 1.1 yes 66.0 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 13.989999930063883 10350481 10.1021/bi9901228 1999 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3187 1721 148 I107V Lysozyme C Homo sapiens 1.84 78.47 -2.7 yes 46.5 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 13.331249952316284 in pocket 9677301 10.1006/jmbi.1998.1906 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3211 1721 148 I107V Lysozyme C Homo sapiens 87.3 88.3 yes 53.8 glycine 0.05 M DSC Thermal 3.1 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 13.331249952316284 in pocket 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3212 1721 148 I107V Lysozyme C Homo sapiens 82.3 88.0 yes 51.8 glycine 0.05 M DSC Thermal 2.96 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 13.331249952316284 in pocket 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3213 1721 148 I107V Lysozyme C Homo sapiens 77.3 82.3 yes 48.4 glycine 0.05 M DSC Thermal 2.78 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 13.331249952316284 in pocket 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3214 1721 148 I107V Lysozyme C Homo sapiens 71.8 76.6 yes 45.5 glycine 0.05 M DSC Thermal 2.66 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 13.331249952316284 in pocket 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3215 1721 148 I107V Lysozyme C Homo sapiens 66.0 72.0 yes 42.5 glycine 0.05 M DSC Thermal 2.49 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 13.331249952316284 in pocket 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 4156 1721 148 I107V Lysozyme C Homo sapiens 1.91 115.8 121.8 -1.4 yes 63.5 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 13.331249952316284 in pocket 7473760 10.1006/jmbi.1995.0599 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6885 1721 148 I107V Lysozyme C Homo sapiens 1.91 0.48 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 13.331249952316284 in pocket 7473760 10.1006/jmbi.1995.0599 1995 ProTherm capriotti_S1615_map.csv 7741 1721 148 I107V Lysozyme C Homo sapiens 1.84 0.35 yes glycine 0.05 M 49.2 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 13.331249952316284 in pocket 9677301 10.1006/jmbi.1998.1906 1998 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 3340 1755 148 I107A Lysozyme C Homo sapiens 1.51 106.2 110.0 yes 62.9 glycine 0.05 M DSC Thermal 3.09 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 13.331249952316284 in pocket 9398521 10.1006/jmbi.1997.1365 1997 ProTherm 3341 1755 148 I107A Lysozyme C Homo sapiens 1.67 103.1 108.1 yes 61.1 glycine 0.05 M DSC Thermal 2.95 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 13.331249952316284 in pocket 9398521 10.1006/jmbi.1997.1365 1997 ProTherm 3342 1755 148 I107A Lysozyme C Homo sapiens 1.08 97.8 103.1 yes 57.7 glycine 0.05 M DSC Thermal 2.8 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 13.331249952316284 in pocket 9398521 10.1006/jmbi.1997.1365 1997 ProTherm 3343 1755 148 I107A Lysozyme C Homo sapiens 1.39 93.1 98.1 yes 55.4 glycine 0.05 M DSC Thermal 2.66 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 13.331249952316284 in pocket 9398521 10.1006/jmbi.1997.1365 1997 ProTherm 3344 1755 148 I107A Lysozyme C Homo sapiens 1.72 89.5 95.5 yes 52.6 glycine 0.05 M DSC Thermal 2.5 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 13.331249952316284 in pocket 9398521 10.1006/jmbi.1997.1365 1997 ProTherm 3359 1755 148 I107A Lysozyme C Homo sapiens 1.65 -8.7 yes 56.2 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 13.331249952316284 in pocket 9398521 10.1006/jmbi.1997.1365 1997 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6906 1755 148 I107A Lysozyme C Homo sapiens 1.65 2.7 109.6 113.0 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 13.331249952316284 in pocket 9398521 10.1006/jmbi.1997.1365 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 1050 633 148 D109P Lysozyme C Homo sapiens 1.57 -1.1 yes 67.7 glycine-HCl 50 mM DSC Thermal 2.8 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.31125009059906 in pocket 1643041 10.1021/bi00146a008 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6703 633 148 D109P Lysozyme C Homo sapiens 1.57 0.4 115.4 yes glycine-HCl 50 mM 68.8 DSC Thermal 2.8 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.31125009059906 in pocket 1643041 10.1021/bi00146a008 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 9882 633 148 D109P Lysozyme C Homo sapiens 2.78 0.8 8.9 5.42 yes (100%) glycine-HCl 40 mM 25.0 CD GdnHCl 3.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 17.31125009059906 in pocket 1911779 10.1021/bi00105a011 1991 ProTherm 314 175 148 A110S Lysozyme C Homo sapiens 2.01 2.6 yes 67.5 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 1LZ1 12.656000137329102 in pocket 11294653 10.1021/bi002792f 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6850 175 148 A110S Lysozyme C Homo sapiens 2.01 103.73 yes Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 1LZ1 12.656000137329102 in pocket 11294653 10.1021/bi002792f 2001 ProTherm 6858 175 148 A110S Lysozyme C Homo sapiens -0.81 yes Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 1LZ1 12.656000137329102 in pocket 11294653 10.1021/bi002792f 2001 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 315 176 148 V111T Lysozyme C Homo sapiens 1.12 -2.3 yes 62.6 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 1LZ1 10.895714214869908 11294653 10.1021/bi002792f 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6851 176 148 V111T Lysozyme C Homo sapiens 1.12 100.62 yes Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 1LZ1 10.895714214869908 11294653 10.1021/bi002792f 2001 ProTherm 6859 176 148 V111T Lysozyme C Homo sapiens 0.67 yes Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 1LZ1 10.895714214869908 11294653 10.1021/bi002792f 2001 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3191 1725 148 V111A Lysozyme C Homo sapiens 1.53 76.32 -4.4 yes 44.8 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 1LZ1 10.895714214869908 9677301 10.1006/jmbi.1998.1906 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3228 1725 148 V111A Lysozyme C Homo sapiens 81.8 86.4 yes 52.5 glycine 0.05 M DSC Thermal 3.16 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 1LZ1 10.895714214869908 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3229 1725 148 V111A Lysozyme C Homo sapiens 77.5 83.0 yes 50.1 glycine 0.05 M DSC Thermal 3.02 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 1LZ1 10.895714214869908 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3230 1725 148 V111A Lysozyme C Homo sapiens 73.2 79.9 yes 47.7 glycine 0.05 M DSC Thermal 2.88 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 1LZ1 10.895714214869908 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3231 1725 148 V111A Lysozyme C Homo sapiens 71.1 77.3 -4.0 yes 45.2 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 1LZ1 10.895714214869908 9677301 10.1006/jmbi.1998.1906 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3232 1725 148 V111A Lysozyme C Homo sapiens 64.1 71.1 yes 41.2 glycine 0.05 M DSC Thermal 2.5 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 1LZ1 10.895714214869908 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 4167 1725 148 V111A Lysozyme C Homo sapiens 1.53 111.5 119.8 -2.3 yes 62.6 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 1LZ1 10.895714214869908 9020766 10.1021/bi9621829 1997 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6890 1725 148 V111A Lysozyme C Homo sapiens 1.53 0.74 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 1LZ1 10.895714214869908 9020766 10.1021/bi9621829 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 7745 1725 148 V111A Lysozyme C Homo sapiens 1.53 1.0 yes glycine 0.05 M 49.2 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 1LZ1 10.895714214869908 9677301 10.1006/jmbi.1998.1906 1998 ProTherm capriotti_S1615_map.csv 316 177 148 A114S Lysozyme C Homo sapiens 1.29 -3.3 yes 61.6 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 11.730000114440918 11294653 10.1021/bi002792f 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6852 177 148 A114S Lysozyme C Homo sapiens 1.29 103.25 yes Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 11.730000114440918 11294653 10.1021/bi002792f 2001 ProTherm 6860 177 148 A114S Lysozyme C Homo sapiens 1.0 yes Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 11.730000114440918 11294653 10.1021/bi002792f 2001 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3899 2023 148 A114M Lysozyme C Homo sapiens 95.12 97.99 yes 62.5 glycine 0.05 M DSC Thermal 2.56 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 11.730000114440918 10469827 10.1093/protein/12.8.663 1999 ProTherm 3900 2023 148 A114M Lysozyme C Homo sapiens 101.1 103.01 yes 66.5 glycine 0.05 M DSC Thermal 2.77 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 11.730000114440918 10469827 10.1093/protein/12.8.663 1999 ProTherm 3901 2023 148 A114M Lysozyme C Homo sapiens 108.99 112.09 yes 72.9 glycine 0.05 M DSC Thermal 3.19 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 11.730000114440918 10469827 10.1093/protein/12.8.663 1999 ProTherm 3913 2023 148 A114M Lysozyme C Homo sapiens 1.31 98.71 0.1 yes 65.0 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 11.730000114440918 10469827 10.1093/protein/12.8.663 1999 ProTherm AUTOMUTE_S1962.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3922 2023 148 A114M Lysozyme C Homo sapiens yes 64.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 11.730000114440918 10469827 10.1093/protein/12.8.663 1999 ProTherm 6916 2023 148 A114M Lysozyme C Homo sapiens -0.02 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 11.730000114440918 10469827 10.1093/protein/12.8.663 1999 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 317 178 148 V117T Lysozyme C Homo sapiens 1.41 -1.6 yes 63.3 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 13.637142862592425 in tunnel in pocket 11294653 10.1021/bi002792f 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6853 178 148 V117T Lysozyme C Homo sapiens 1.41 104.45 yes Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 13.637142862592425 in tunnel in pocket 11294653 10.1021/bi002792f 2001 ProTherm 6861 178 148 V117T Lysozyme C Homo sapiens 0.5 yes Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 13.637142862592425 in tunnel in pocket 11294653 10.1021/bi002792f 2001 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3192 1726 148 V117A Lysozyme C Homo sapiens 1.27 66.99 -4.4 yes 44.8 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 13.637142862592425 in tunnel in pocket 9677301 10.1006/jmbi.1998.1906 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3233 1726 148 V117A Lysozyme C Homo sapiens 70.6 73.7 yes 52.6 glycine 0.05 M DSC Thermal 3.1 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 13.637142862592425 in tunnel in pocket 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3234 1726 148 V117A Lysozyme C Homo sapiens 68.9 72.2 yes 51.0 glycine 0.05 M DSC Thermal 3.02 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 13.637142862592425 in tunnel in pocket 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3235 1726 148 V117A Lysozyme C Homo sapiens 67.2 70.6 yes 48.2 glycine 0.05 M DSC Thermal 2.85 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 13.637142862592425 in tunnel in pocket 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3236 1726 148 V117A Lysozyme C Homo sapiens 62.2 65.8 yes 45.3 glycine 0.05 M DSC Thermal 2.72 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 13.637142862592425 in tunnel in pocket 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3237 1726 148 V117A Lysozyme C Homo sapiens 56.0 59.6 yes 41.4 glycine 0.05 M DSC Thermal 2.54 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 13.637142862592425 in tunnel in pocket 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 4168 1726 148 V117A Lysozyme C Homo sapiens 1.58 110.8 116.6 -3.0 yes 61.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 13.637142862592425 in tunnel in pocket 9020766 10.1021/bi9621829 1997 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6891 1726 148 V117A Lysozyme C Homo sapiens 1.58 0.98 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 13.637142862592425 in tunnel in pocket 9020766 10.1021/bi9621829 1997 ProTherm capriotti_S1615_map.csv 7746 1726 148 V117A Lysozyme C Homo sapiens 1.27 0.89 yes glycine 0.05 M 49.2 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 13.637142862592425 in tunnel in pocket 9677301 10.1006/jmbi.1998.1906 1998 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 318 179 148 V118T Lysozyme C Homo sapiens 1.53 -0.9 yes 64.0 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 16.83714267185756 11294653 10.1021/bi002792f 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6854 179 148 V118T Lysozyme C Homo sapiens 1.53 106.84 yes Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 16.83714267185756 11294653 10.1021/bi002792f 2001 ProTherm 6862 179 148 V118T Lysozyme C Homo sapiens 0.29 yes Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 16.83714267185756 11294653 10.1021/bi002792f 2001 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3193 1727 148 V118A Lysozyme C Homo sapiens 1.84 72.25 -2.6 yes 46.6 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 16.83714267185756 9677301 10.1006/jmbi.1998.1906 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3238 1727 148 V118A Lysozyme C Homo sapiens 81.8 84.7 yes 54.4 glycine 0.05 M DSC Thermal 3.15 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 16.83714267185756 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3239 1727 148 V118A Lysozyme C Homo sapiens 77.8 81.6 yes 52.0 glycine 0.05 M DSC Thermal 3.02 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 16.83714267185756 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3240 1727 148 V118A Lysozyme C Homo sapiens 72.5 79.2 yes 49.9 glycine 0.05 M DSC Thermal 2.9 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 16.83714267185756 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3241 1727 148 V118A Lysozyme C Homo sapiens 68.9 73.4 yes 46.8 glycine 0.05 M DSC Thermal 2.72 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 16.83714267185756 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3242 1727 148 V118A Lysozyme C Homo sapiens 61.5 70.1 yes 43.5 glycine 0.05 M DSC Thermal 2.51 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 16.83714267185756 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 4169 1727 148 V118A Lysozyme C Homo sapiens 1.0 110.3 119.9 -0.8 yes 64.1 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 16.83714267185756 9020766 10.1021/bi9621829 1997 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6892 1727 148 V118A Lysozyme C Homo sapiens 1.0 0.26 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 16.83714267185756 9020766 10.1021/bi9621829 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 7747 1727 148 V118A Lysozyme C Homo sapiens 1.84 0.57 yes glycine 0.05 M 49.2 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 16.83714267185756 9677301 10.1006/jmbi.1998.1906 1998 ProTherm capriotti_S1615_map.csv 3902 2024 148 V118F Lysozyme C Homo sapiens 79.11 85.09 yes 56.8 glycine 0.05 M DSC Thermal 2.62 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 16.83714267185756 10469827 10.1093/protein/12.8.663 1999 ProTherm 3903 2024 148 V118F Lysozyme C Homo sapiens 84.61 92.02 yes 61.0 glycine 0.05 M DSC Thermal 2.83 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 16.83714267185756 10469827 10.1093/protein/12.8.663 1999 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 3904 2024 148 V118F Lysozyme C Homo sapiens 89.39 95.36 yes 67.6 glycine 0.05 M DSC Thermal 3.26 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 16.83714267185756 10469827 10.1093/protein/12.8.663 1999 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, EASE-MM_S1676.csv, M47andM8_S1810.csv, STRUM_Q3421.csv 3914 2024 148 V118F Lysozyme C Homo sapiens 0.93 87.24 -6.5 yes 58.4 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 16.83714267185756 10469827 10.1093/protein/12.8.663 1999 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3923 2024 148 V118F Lysozyme C Homo sapiens yes 64.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 16.83714267185756 10469827 10.1093/protein/12.8.663 1999 ProTherm 6917 2024 148 V118F Lysozyme C Homo sapiens 1.65 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 16.83714267185756 10469827 10.1093/protein/12.8.663 1999 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 48 48 148 D120N Lysozyme C Homo sapiens 0.6 yes 58.1 glycine hydrochloride 0.05 M DSC Thermal 2.2 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 31.25374937057495 11015217 10.1021/bi000849s 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 54 48 148 D120N Lysozyme C Homo sapiens -1.8 yes 78.3 sodium acetate 0.02 M DSC Thermal 4.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 31.25374937057495 11015217 10.1021/bi000849s 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 58 48 148 D120N Lysozyme C Homo sapiens 0.5 yes 56.7 glycine hydrochloride 0.05 M KCl 0.2 M DSC Thermal 2.3 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 31.25374937057495 11015217 10.1021/bi000849s 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 62 48 148 D120N Lysozyme C Homo sapiens 0.2 yes 77.9 sodium acetate 0.02 M KCl 0.2 M DSC Thermal 4.5 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 31.25374937057495 11015217 10.1021/bi000849s 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6841 48 148 D120N Lysozyme C Homo sapiens 0.67 4.76 yes sodium acetate 0.02 M 65.0 DSC Thermal 4.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 31.25374937057495 11015217 10.1021/bi000849s 2000 ProTherm 6845 48 148 D120N Lysozyme C Homo sapiens -0.07 4.13 yes sodium acetate 0.02 M 65.0 KCl 0.2 M DSC Thermal 4.5 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 1LZ1 31.25374937057495 11015217 10.1021/bi000849s 2000 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1049 632 148 P121G Lysozyme C Homo sapiens 1.58 -0.1 yes 68.7 glycine-HCl 50 mM DSC Thermal 2.8 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 60.60857173374721 1643041 10.1021/bi00146a008 1992 ProTherm HotMuSiC_S1626.csv, Saraboji_S1791.csv 6702 632 148 P121G Lysozyme C Homo sapiens 1.58 0.1 119.7 yes glycine-HCl 50 mM 68.8 DSC Thermal 2.8 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 60.60857173374721 1643041 10.1021/bi00146a008 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 9880 632 148 P121G Lysozyme C Homo sapiens 2.95 0.0 9.7 5.55 yes (100%) glycine-HCl 40 mM 25.0 CD GdnHCl 3.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 60.60857173374721 1911779 10.1021/bi00105a011 1991 ProTherm 520 294 148 G123A Lysozyme C Homo sapiens 90.82 yes 56.1 Gly-HCl 0.05 M DSC Thermal 2.3 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 18.59499979019165 11599030 10.1002/prot.1147 2001 ProTherm 521 294 148 G123A Lysozyme C Homo sapiens 97.51 yes 61.3 Gly-HCl 0.05 M DSC Thermal 2.65 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 18.59499979019165 11599030 10.1002/prot.1147 2001 ProTherm 522 294 148 G123A Lysozyme C Homo sapiens 112.09 yes 71.8 Gly-HCl 0.05 M DSC Thermal 3.2 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 18.59499979019165 11599030 10.1002/prot.1147 2001 ProTherm 536 294 148 G123A Lysozyme C Homo sapiens 1.36 102.53 -2.1 yes 62.8 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 18.59499979019165 11599030 10.1002/prot.1147 2001 ProTherm M47andM8_S2760.csv 6879 294 148 G123A Lysozyme C Homo sapiens 5.7 0.62 yes Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 18.59499979019165 11599030 10.1002/prot.1147 2001 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3188 1722 148 I124V Lysozyme C Homo sapiens 1.72 70.33 -4.7 yes 44.5 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 19.34999990463257 9677301 10.1006/jmbi.1998.1906 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3216 1722 148 I124V Lysozyme C Homo sapiens 73.7 78.0 yes 51.3 glycine 0.05 M DSC Thermal 3.1 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 19.34999990463257 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3217 1722 148 I124V Lysozyme C Homo sapiens 70.6 75.6 yes 49.5 glycine 0.05 M DSC Thermal 3.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 19.34999990463257 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3218 1722 148 I124V Lysozyme C Homo sapiens 66.0 69.9 yes 46.0 glycine 0.05 M DSC Thermal 2.79 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 19.34999990463257 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3219 1722 148 I124V Lysozyme C Homo sapiens 59.8 66.7 -5.6 yes 43.6 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 19.34999990463257 9677301 10.1006/jmbi.1998.1906 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4157 1722 148 I124V Lysozyme C Homo sapiens 1.41 109.3 113.8 -2.2 yes 62.7 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 19.34999990463257 7473760 10.1006/jmbi.1995.0599 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6886 1722 148 I124V Lysozyme C Homo sapiens 1.41 0.72 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 19.34999990463257 7473760 10.1006/jmbi.1995.0599 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 7742 1722 148 I124V Lysozyme C Homo sapiens 1.72 0.98 yes glycine 0.05 M 49.2 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 19.34999990463257 9677301 10.1006/jmbi.1998.1906 1998 ProTherm capriotti_S1615_map.csv 3345 1756 148 I124A Lysozyme C Homo sapiens 1.58 112.2 119.1 yes 69.7 glycine 0.05 M DSC Thermal 3.1 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 19.34999990463257 9398521 10.1006/jmbi.1997.1365 1997 ProTherm 3346 1756 148 I124A Lysozyme C Homo sapiens 1.17 109.1 114.1 yes 67.4 glycine 0.05 M DSC Thermal 2.96 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 19.34999990463257 9398521 10.1006/jmbi.1997.1365 1997 ProTherm 3347 1756 148 I124A Lysozyme C Homo sapiens 0.98 104.1 111.0 yes 64.1 glycine 0.05 M DSC Thermal 2.8 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 19.34999990463257 9398521 10.1006/jmbi.1997.1365 1997 ProTherm 3348 1756 148 I124A Lysozyme C Homo sapiens 1.36 100.0 108.1 yes 61.3 glycine 0.05 M DSC Thermal 2.66 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 19.34999990463257 9398521 10.1006/jmbi.1997.1365 1997 ProTherm 3349 1756 148 I124A Lysozyme C Homo sapiens 1.15 96.4 102.2 yes 57.7 glycine 0.05 M DSC Thermal 2.51 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 19.34999990463257 9398521 10.1006/jmbi.1997.1365 1997 ProTherm 3360 1756 148 I124A Lysozyme C Homo sapiens 1.34 -3.0 yes 61.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 19.34999990463257 9398521 10.1006/jmbi.1997.1365 1997 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6907 1756 148 I124A Lysozyme C Homo sapiens 1.34 0.93 105.5 112.2 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 1LZ1 19.34999990463257 9398521 10.1006/jmbi.1997.1365 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 1052 635 148 V128P Lysozyme C Homo sapiens 1.57 1.2 yes 70.0 glycine-HCl 50 mM DSC Thermal 2.8 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 1643041 10.1021/bi00146a008 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6705 635 148 V128P Lysozyme C Homo sapiens 1.57 -0.5 120.3 yes glycine-HCl 50 mM 68.8 DSC Thermal 2.8 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 1643041 10.1021/bi00146a008 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 9883 635 148 V128P Lysozyme C Homo sapiens 3.05 -2.4 12.1 6.69 yes (100%) glycine-HCl 40 mM 25.0 CD GdnHCl 3.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 1911779 10.1021/bi00105a011 1991 ProTherm 1144 680 148 V128G Lysozyme C Homo sapiens 99.9 yes 64.6 glycine-HCl 0.05 M DSC Thermal 2.6 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11087397 10.1021/bi0015717 2000 ProTherm 1145 680 148 V128G Lysozyme C Homo sapiens 103.97 yes 67.11 glycine-HCl 0.05 M DSC Thermal 2.73 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11087397 10.1021/bi0015717 2000 ProTherm 1146 680 148 V128G Lysozyme C Homo sapiens 109.94 yes 70.59 glycine-HCl 0.05 M DSC Thermal 2.94 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11087397 10.1021/bi0015717 2000 ProTherm 1147 680 148 V128G Lysozyme C Homo sapiens 114.96 yes 73.44 glycine-HCl 0.05 M DSC Thermal 3.11 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11087397 10.1021/bi0015717 2000 ProTherm 1148 680 148 V128G Lysozyme C Homo sapiens 121.89 yes 76.63 glycine-HCl 0.05 M DSC Thermal 3.3 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11087397 10.1021/bi0015717 2000 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv 1176 680 148 V128G Lysozyme C Homo sapiens 1.82 99.9 1.6 yes 66.5 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11087397 10.1021/bi0015717 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 1191 680 148 V128G Lysozyme C Homo sapiens yes 64.9 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11087397 10.1021/bi0015717 2000 ProTherm 6949 680 148 V128G Lysozyme C Homo sapiens -0.48 yes glycine-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11087397 10.1021/bi0015717 2000 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1149 681 148 V128I Lysozyme C Homo sapiens 107.07 yes 64.89 glycine-HCl 0.05 M DSC Thermal 2.53 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11087397 10.1021/bi0015717 2000 ProTherm 1150 681 148 V128I Lysozyme C Homo sapiens 110.9 yes 67.27 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11087397 10.1021/bi0015717 2000 ProTherm 1151 681 148 V128I Lysozyme C Homo sapiens 117.11 yes 70.93 glycine-HCl 0.05 M DSC Thermal 2.9 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11087397 10.1021/bi0015717 2000 ProTherm 1152 681 148 V128I Lysozyme C Homo sapiens 123.09 yes 74.86 glycine-HCl 0.05 M DSC Thermal 3.13 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11087397 10.1021/bi0015717 2000 ProTherm 1153 681 148 V128I Lysozyme C Homo sapiens 126.91 yes 76.82 glycine-HCl 0.05 M DSC Thermal 3.23 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11087397 10.1021/bi0015717 2000 ProTherm 1177 681 148 V128I Lysozyme C Homo sapiens 1.65 106.84 2.7 yes 67.6 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11087397 10.1021/bi0015717 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 1192 681 148 V128I Lysozyme C Homo sapiens yes 64.9 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11087397 10.1021/bi0015717 2000 ProTherm 6950 681 148 V128I Lysozyme C Homo sapiens -0.86 yes glycine-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11087397 10.1021/bi0015717 2000 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1154 682 148 V128L Lysozyme C Homo sapiens 105.16 yes 61.92 glycine-HCl 0.05 M DSC Thermal 2.5 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11087397 10.1021/bi0015717 2000 ProTherm 1155 682 148 V128L Lysozyme C Homo sapiens 108.03 yes 65.02 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11087397 10.1021/bi0015717 2000 ProTherm 1156 682 148 V128L Lysozyme C Homo sapiens 111.14 yes 67.01 glycine-HCl 0.05 M DSC Thermal 2.82 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11087397 10.1021/bi0015717 2000 ProTherm 1157 682 148 V128L Lysozyme C Homo sapiens 114.96 yes 70.53 glycine-HCl 0.05 M DSC Thermal 3.03 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11087397 10.1021/bi0015717 2000 ProTherm 1158 682 148 V128L Lysozyme C Homo sapiens 121.18 yes 74.52 glycine-HCl 0.05 M DSC Thermal 3.25 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11087397 10.1021/bi0015717 2000 ProTherm 1178 682 148 V128L Lysozyme C Homo sapiens 1.29 108.51 0.2 yes 65.1 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11087397 10.1021/bi0015717 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 1193 682 148 V128L Lysozyme C Homo sapiens yes 64.9 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11087397 10.1021/bi0015717 2000 ProTherm 6951 682 148 V128L Lysozyme C Homo sapiens -0.07 yes glycine-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11087397 10.1021/bi0015717 2000 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1159 683 148 V128M Lysozyme C Homo sapiens 108.99 yes 62.8 glycine-HCl 0.05 M DSC Thermal 2.48 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11087397 10.1021/bi0015717 2000 ProTherm 1160 683 148 V128M Lysozyme C Homo sapiens 114.01 yes 66.34 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11087397 10.1021/bi0015717 2000 ProTherm 1161 683 148 V128M Lysozyme C Homo sapiens 118.07 yes 69.11 glycine-HCl 0.05 M DSC Thermal 2.85 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11087397 10.1021/bi0015717 2000 ProTherm 1162 683 148 V128M Lysozyme C Homo sapiens 123.09 yes 72.79 glycine-HCl 0.05 M DSC Thermal 3.06 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11087397 10.1021/bi0015717 2000 ProTherm 1179 683 148 V128M Lysozyme C Homo sapiens 1.41 111.85 1.6 yes 66.5 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11087397 10.1021/bi0015717 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 1194 683 148 V128M Lysozyme C Homo sapiens yes 64.9 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11087397 10.1021/bi0015717 2000 ProTherm 6952 683 148 V128M Lysozyme C Homo sapiens -0.53 yes glycine-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11087397 10.1021/bi0015717 2000 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1163 684 148 V128F Lysozyme C Homo sapiens 101.1 yes 65.11 glycine-HCl 0.05 M DSC Thermal 2.72 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11087397 10.1021/bi0015717 2000 ProTherm 1164 684 148 V128F Lysozyme C Homo sapiens 103.01 yes 66.29 glycine-HCl 0.05 M DSC Thermal 2.8 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11087397 10.1021/bi0015717 2000 ProTherm 1165 684 148 V128F Lysozyme C Homo sapiens 110.18 yes 70.49 glycine-HCl 0.05 M DSC Thermal 3.04 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11087397 10.1021/bi0015717 2000 ProTherm 1180 684 148 V128F Lysozyme C Homo sapiens 1.7 100.62 -0.2 yes 64.7 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11087397 10.1021/bi0015717 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 1195 684 148 V128F Lysozyme C Homo sapiens yes 64.9 glycine-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11087397 10.1021/bi0015717 2000 ProTherm 6953 684 148 V128F Lysozyme C Homo sapiens 0.05 yes glycine-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11087397 10.1021/bi0015717 2000 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1299 728 148 V128Y Lysozyme C Homo sapiens 106.12 105.16 Unknown 63.3 Gly-HCl 0.05 M DSC Thermal 2.66 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv 1300 728 148 V128Y Lysozyme C Homo sapiens 111.14 111.14 Unknown 67.3 Gly-HCl 0.05 M DSC Thermal 2.85 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11927576 10.1074/jbc.M110728200 2002 ProTherm 1301 728 148 V128Y Lysozyme C Homo sapiens 114.01 114.01 Unknown 69.3 Gly-HCl 0.05 M DSC Thermal 2.98 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11927576 10.1074/jbc.M110728200 2002 ProTherm 1302 728 148 V128Y Lysozyme C Homo sapiens 119.98 121.18 Unknown 72.2 Gly-HCl 0.05 M DSC Thermal 3.18 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11927576 10.1074/jbc.M110728200 2002 ProTherm 1303 728 148 V128Y Lysozyme C Homo sapiens 125.0 125.0 Unknown 75.4 Gly-HCl 0.05 M DSC Thermal 3.38 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv 1327 728 148 V128Y Lysozyme C Homo sapiens -0.5 Unknown 64.4 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6964 728 148 V128Y Lysozyme C Homo sapiens 0.14 107.79 Unknown Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11927576 10.1074/jbc.M110728200 2002 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1304 729 148 V128D Lysozyme C Homo sapiens 90.34 108.03 Unknown 63.9 Gly-HCl 0.05 M DSC Thermal 2.63 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv 1305 729 148 V128D Lysozyme C Homo sapiens 96.8 112.09 Unknown 67.9 Gly-HCl 0.05 M DSC Thermal 2.84 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv 1306 729 148 V128D Lysozyme C Homo sapiens 103.01 119.98 Unknown 70.4 Gly-HCl 0.05 M DSC Thermal 3.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv 1307 729 148 V128D Lysozyme C Homo sapiens 105.16 122.13 Unknown 72.4 Gly-HCl 0.05 M DSC Thermal 3.13 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv 1308 729 148 V128D Lysozyme C Homo sapiens 108.03 125.0 Unknown 75.5 Gly-HCl 0.05 M DSC Thermal 3.34 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv 1328 729 148 V128D Lysozyme C Homo sapiens 0.5 Unknown 65.4 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6965 729 148 V128D Lysozyme C Homo sapiens -0.17 92.26 Unknown Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11927576 10.1074/jbc.M110728200 2002 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1309 730 148 V128N Lysozyme C Homo sapiens 108.03 108.99 Unknown 64.0 Gly-HCl 0.05 M DSC Thermal 2.64 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv 1310 730 148 V128N Lysozyme C Homo sapiens 113.05 114.96 Unknown 67.2 Gly-HCl 0.05 M DSC Thermal 2.83 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv 1311 730 148 V128N Lysozyme C Homo sapiens 118.07 118.07 Unknown 70.6 Gly-HCl 0.05 M DSC Thermal 3.04 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv 1312 730 148 V128N Lysozyme C Homo sapiens 119.98 121.89 Unknown 71.7 Gly-HCl 0.05 M DSC Thermal 3.13 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv 1329 730 148 V128N Lysozyme C Homo sapiens 0.2 Unknown 65.1 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6966 730 148 V128N Lysozyme C Homo sapiens -0.07 109.23 Unknown Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11927576 10.1074/jbc.M110728200 2002 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1313 731 148 V128R Lysozyme C Homo sapiens 106.12 108.99 Unknown 68.2 Gly-HCl 0.05 M DSC Thermal 2.72 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv 1314 731 148 V128R Lysozyme C Homo sapiens 108.03 110.18 Unknown 69.3 Gly-HCl 0.05 M DSC Thermal 2.8 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv 1315 731 148 V128R Lysozyme C Homo sapiens 114.01 116.16 Unknown 72.8 Gly-HCl 0.05 M DSC Thermal 3.01 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv 1316 731 148 V128R Lysozyme C Homo sapiens 117.11 119.98 Unknown 75.0 Gly-HCl 0.05 M DSC Thermal 3.15 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11927576 10.1074/jbc.M110728200 2002 ProTherm 1330 731 148 V128R Lysozyme C Homo sapiens 2.9 Unknown 67.8 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11927576 10.1074/jbc.M110728200 2002 ProTherm HotMuSiC_S1626.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6967 731 148 V128R Lysozyme C Homo sapiens -0.88 100.62 Unknown Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 11927576 10.1074/jbc.M110728200 2002 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3194 1728 148 V128A Lysozyme C Homo sapiens 1.51 80.86 0.3 yes 49.5 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 9677301 10.1006/jmbi.1998.1906 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3243 1728 148 V128A Lysozyme C Homo sapiens 93.3 93.3 yes 57.2 glycine 0.05 M DSC Thermal 3.13 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3244 1728 148 V128A Lysozyme C Homo sapiens 89.0 93.1 yes 55.0 glycine 0.05 M DSC Thermal 3.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3245 1728 148 V128A Lysozyme C Homo sapiens 85.9 87.6 yes 52.5 glycine 0.05 M DSC Thermal 2.87 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3246 1728 148 V128A Lysozyme C Homo sapiens 83.0 83.5 yes 50.0 glycine 0.05 M DSC Thermal 2.73 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3247 1728 148 V128A Lysozyme C Homo sapiens 76.8 78.0 yes 46.8 glycine 0.05 M DSC Thermal 2.55 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 4170 1728 148 V128A Lysozyme C Homo sapiens 1.24 115.8 121.88 1.5 yes 66.4 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 9020766 10.1021/bi9621829 1997 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6893 1728 148 V128A Lysozyme C Homo sapiens 1.24 -0.53 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 9020766 10.1021/bi9621829 1997 ProTherm capriotti_S1615_map.csv 7748 1728 148 V128A Lysozyme C Homo sapiens 1.51 -0.07 yes glycine 0.05 M 49.2 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 29.57285717555455 in tunnel in pocket 9677301 10.1006/jmbi.1998.1906 1998 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 356 195 148 N136A Lysozyme C Homo sapiens 99.9 106.12 yes 62.1 Gly-HCl 0.05 M DSC Thermal 2.51 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 52.84750056266785 11455596 10.1002/prot.1088 2001 ProTherm HotMuSiC_S1626.csv, M47andM8_S2760.csv, SVM-WIN31_SVM-3D12_S499.csv 357 195 148 N136A Lysozyme C Homo sapiens 107.07 112.09 yes 66.2 Gly-HCl 0.05 M DSC Thermal 2.74 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 52.84750056266785 11455596 10.1002/prot.1088 2001 ProTherm HotMuSiC_S1626.csv 358 195 148 N136A Lysozyme C Homo sapiens 108.99 117.11 yes 68.6 Gly-HCl 0.05 M DSC Thermal 2.87 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 52.84750056266785 11455596 10.1002/prot.1088 2001 ProTherm HotMuSiC_S1626.csv 359 195 148 N136A Lysozyme C Homo sapiens 110.9 118.07 yes 70.9 Gly-HCl 0.05 M DSC Thermal 3.02 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 52.84750056266785 11455596 10.1002/prot.1088 2001 ProTherm 370 195 148 N136A Lysozyme C Homo sapiens 1.24 104.21 0.6 yes 65.5 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 52.84750056266785 11455596 10.1002/prot.1088 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6870 195 148 N136A Lysozyme C Homo sapiens -0.19 yes Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 52.84750056266785 11455596 10.1002/prot.1088 2001 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 360 196 148 N136G Lysozyme C Homo sapiens 103.01 109.94 yes 65.7 Gly-HCl 0.05 M DSC Thermal 2.74 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 52.84750056266785 11455596 10.1002/prot.1088 2001 ProTherm 361 196 148 N136G Lysozyme C Homo sapiens 107.07 114.96 yes 69.3 Gly-HCl 0.05 M DSC Thermal 2.95 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 52.84750056266785 11455596 10.1002/prot.1088 2001 ProTherm 362 196 148 N136G Lysozyme C Homo sapiens 113.05 119.02 yes 71.6 Gly-HCl 0.05 M DSC Thermal 3.1 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 52.84750056266785 11455596 10.1002/prot.1088 2001 ProTherm 371 196 148 N136G Lysozyme C Homo sapiens 1.65 101.1 0.2 yes 65.1 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 52.84750056266785 11455596 10.1002/prot.1088 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6871 196 148 N136G Lysozyme C Homo sapiens -0.05 yes Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 52.84750056266785 11455596 10.1002/prot.1088 2001 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 49 49 148 D138N Lysozyme C Homo sapiens 0.3 yes 57.8 glycine hydrochloride 0.05 M DSC Thermal 2.2 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 56.29750061035156 11015217 10.1021/bi000849s 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 55 49 148 D138N Lysozyme C Homo sapiens -1.8 yes 78.3 sodium acetate 0.02 M DSC Thermal 4.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 56.29750061035156 11015217 10.1021/bi000849s 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 59 49 148 D138N Lysozyme C Homo sapiens 0.7 yes 56.9 glycine hydrochloride 0.05 M KCl 0.2 M DSC Thermal 2.3 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 56.29750061035156 11015217 10.1021/bi000849s 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 63 49 148 D138N Lysozyme C Homo sapiens 0.1 yes 77.8 sodium acetate 0.02 M KCl 0.2 M DSC Thermal 4.5 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 56.29750061035156 11015217 10.1021/bi000849s 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6842 49 148 D138N Lysozyme C Homo sapiens 0.67 4.76 yes sodium acetate 0.02 M 65.0 DSC Thermal 4.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 56.29750061035156 11015217 10.1021/bi000849s 2000 ProTherm 6846 49 148 D138N Lysozyme C Homo sapiens -0.05 4.13 yes sodium acetate 0.02 M 65.0 KCl 0.2 M DSC Thermal 4.5 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 56.29750061035156 11015217 10.1021/bi000849s 2000 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3195 1729 148 V139A Lysozyme C Homo sapiens 1.37 65.31 -9.3 yes 39.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 24.542857306344168 9677301 10.1006/jmbi.1998.1906 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3248 1729 148 V139A Lysozyme C Homo sapiens 67.2 72.5 -7.7 yes 50.1 glycine 0.05 M DSC Thermal 3.14 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 24.542857306344168 9677301 10.1006/jmbi.1998.1906 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3249 1729 148 V139A Lysozyme C Homo sapiens 61.5 67.5 yes 47.0 glycine 0.05 M DSC Thermal 3.0 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 24.542857306344168 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3250 1729 148 V139A Lysozyme C Homo sapiens 57.9 62.7 yes 43.6 glycine 0.05 M DSC Thermal 2.86 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 24.542857306344168 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3251 1729 148 V139A Lysozyme C Homo sapiens 53.6 56.9 yes 40.3 glycine 0.05 M DSC Thermal 2.72 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 24.542857306344168 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 4171 1729 148 V139A Lysozyme C Homo sapiens 1.53 110.0 112.3 -4.5 yes 60.4 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 24.542857306344168 9020766 10.1021/bi9621829 1997 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6894 1729 148 V139A Lysozyme C Homo sapiens 1.53 1.44 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 24.542857306344168 9020766 10.1021/bi9621829 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 7749 1729 148 V139A Lysozyme C Homo sapiens 1.37 1.75 yes glycine 0.05 M 49.2 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 24.542857306344168 9677301 10.1006/jmbi.1998.1906 1998 ProTherm capriotti_S1615_map.csv 3267 1737 148 Y142F Lysozyme C Homo sapiens 1.46 114.1 118.9 -1.1 yes 63.8 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 22.901666800181072 9649316 10.1021/bi980431i 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3290 1737 148 Y142F Lysozyme C Homo sapiens 1.82 121.1 125.12 yes 69.7 glycine 0.05 M DSC Thermal 3.06 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 22.901666800181072 9649316 10.1021/bi980431i 1998 ProTherm 3291 1737 148 Y142F Lysozyme C Homo sapiens 1.53 113.2 118.18 yes 64.0 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 22.901666800181072 9649316 10.1021/bi980431i 1998 ProTherm 3292 1737 148 Y142F Lysozyme C Homo sapiens 1.08 112.2 116.03 yes 63.4 glycine 0.05 M DSC Thermal 2.68 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 22.901666800181072 9649316 10.1021/bi980431i 1998 ProTherm 3293 1737 148 Y142F Lysozyme C Homo sapiens 1.48 108.1 112.2 yes 60.8 glycine 0.05 M DSC Thermal 2.53 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 22.901666800181072 9649316 10.1021/bi980431i 1998 ProTherm 6902 1737 148 Y142F Lysozyme C Homo sapiens 1.46 0.36 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 22.901666800181072 9649316 10.1021/bi980431i 1998 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 3196 1730 148 V143A Lysozyme C Homo sapiens 1.56 77.99 -7.0 yes 42.2 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 20.082857131958008 9677301 10.1006/jmbi.1998.1906 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3252 1730 148 V143A Lysozyme C Homo sapiens 81.1 82.8 yes 50.8 glycine 0.05 M DSC Thermal 3.17 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 20.082857131958008 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3253 1730 148 V143A Lysozyme C Homo sapiens 76.3 78.0 yes 47.9 glycine 0.05 M DSC Thermal 3.02 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 20.082857131958008 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3254 1730 148 V143A Lysozyme C Homo sapiens 72.2 76.3 yes 45.9 glycine 0.05 M DSC Thermal 2.87 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 20.082857131958008 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3255 1730 148 V143A Lysozyme C Homo sapiens 67.2 70.6 yes 42.8 glycine 0.05 M DSC Thermal 2.72 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 20.082857131958008 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3256 1730 148 V143A Lysozyme C Homo sapiens 62.4 64.1 -6.8 yes 38.7 glycine 0.05 M DSC Thermal 2.53 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 20.082857131958008 9677301 10.1006/jmbi.1998.1906 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4172 1730 148 V143A Lysozyme C Homo sapiens 1.29 112.9 116.4 -4.0 yes 60.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 20.082857131958008 9020766 10.1021/bi9621829 1997 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6895 1730 148 V143A Lysozyme C Homo sapiens 1.29 1.32 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 20.082857131958008 9020766 10.1021/bi9621829 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 7750 1730 148 V143A Lysozyme C Homo sapiens 1.56 1.6 yes glycine 0.05 M 49.2 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 20.082857131958008 9677301 10.1006/jmbi.1998.1906 1998 ProTherm capriotti_S1615_map.csv 523 295 148 G145A Lysozyme C Homo sapiens 94.17 yes 54.6 Gly-HCl 0.05 M DSC Thermal 2.2 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 23.59000015258789 11599030 10.1002/prot.1147 2001 ProTherm 524 295 148 G145A Lysozyme C Homo sapiens 103.97 yes 61.6 Gly-HCl 0.05 M DSC Thermal 2.6 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 23.59000015258789 11599030 10.1002/prot.1147 2001 ProTherm 525 295 148 G145A Lysozyme C Homo sapiens 118.07 yes 71.1 Gly-HCl 0.05 M DSC Thermal 3.16 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 23.59000015258789 11599030 10.1002/prot.1147 2001 ProTherm M47andM8_S2760.csv 537 295 148 G145A Lysozyme C Homo sapiens 1.46 108.99 -1.7 yes 63.2 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 23.59000015258789 11599030 10.1002/prot.1147 2001 ProTherm M47andM8_S2760.csv 6880 295 148 G145A Lysozyme C Homo sapiens 1.46 0.55 yes Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 1LZ1 23.59000015258789 11599030 10.1002/prot.1147 2001 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 526 296 148 G147A Lysozyme C Homo sapiens 99.67 yes 64.9 Gly-HCl 0.05 M DSC Thermal 2.67 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 32.427499294281006 11599030 10.1002/prot.1147 2001 ProTherm 527 296 148 G147A Lysozyme C Homo sapiens 102.06 yes 67.1 Gly-HCl 0.05 M DSC Thermal 2.79 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 32.427499294281006 11599030 10.1002/prot.1147 2001 ProTherm M47andM8_S2760.csv 528 296 148 G147A Lysozyme C Homo sapiens 103.01 yes 67.2 Gly-HCl 0.05 M DSC Thermal 2.8 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 32.427499294281006 11599030 10.1002/prot.1147 2001 ProTherm 538 296 148 G147A Lysozyme C Homo sapiens 1.29 99.67 0.5 yes 65.4 Gly-HCl 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 32.427499294281006 11599030 10.1002/prot.1147 2001 ProTherm 6881 296 148 G147A Lysozyme C Homo sapiens 1.29 -0.14 yes Gly-HCl 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 1LZ1 32.427499294281006 11599030 10.1002/prot.1147 2001 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3197 1731 148 V148A Lysozyme C Homo sapiens 1.87 78.23 -4.8 yes 44.4 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 41.82249999046326 9677301 10.1006/jmbi.1998.1906 1998 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3257 1731 148 V148A Lysozyme C Homo sapiens 84.2 90.2 yes 52.5 glycine 0.05 M DSC Thermal 3.09 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 41.82249999046326 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3258 1731 148 V148A Lysozyme C Homo sapiens 80.1 86.1 yes 49.9 glycine 0.05 M DSC Thermal 2.97 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 41.82249999046326 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3259 1731 148 V148A Lysozyme C Homo sapiens 73.0 79.2 yes 47.0 glycine 0.05 M DSC Thermal 2.82 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 41.82249999046326 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3260 1731 148 V148A Lysozyme C Homo sapiens 69.9 73.0 yes 43.8 glycine 0.05 M DSC Thermal 2.69 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 41.82249999046326 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 3261 1731 148 V148A Lysozyme C Homo sapiens 61.0 67.7 yes 40.4 glycine 0.05 M DSC Thermal 2.5 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 41.82249999046326 9677301 10.1006/jmbi.1998.1906 1998 ProTherm 4173 1731 148 V148A Lysozyme C Homo sapiens 1.51 111.0 119.4 -2.6 yes 62.3 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 41.82249999046326 9020766 10.1021/bi9621829 1997 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6896 1731 148 V148A Lysozyme C Homo sapiens 1.51 0.84 yes glycine 0.05 M 64.9 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 41.82249999046326 9020766 10.1021/bi9621829 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 7751 1731 148 V148A Lysozyme C Homo sapiens 1.87 1.12 yes glycine 0.05 M 49.2 DSC Thermal 2.7 3.2.1.17 P61626 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 1LZ1 41.82249999046326 9677301 10.1006/jmbi.1998.1906 1998 ProTherm capriotti_S1615_map.csv 17439 55 147 Lysozyme C Gallus gallus 93.69 yes 74.8 sodium acetate 240 mM NMR Thermal 3.8 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1409571 10.1002/prot.340140210 1992 ProTherm 17471 55 147 Lysozyme C Gallus gallus yes 74.8 phosphate 66 mM CD Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10813830 2000 ProTherm 17472 55 147 Lysozyme C Gallus gallus 1.58 114.24 yes 65.6 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 11112507 10.1093/protein/13.10.691 2000 ProTherm 17794 55 147 Lysozyme C Gallus gallus 0.38 79.11 84.37 yes 52.65 HCl-glycine 0.2 M DSC Thermal 2.3 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17795 55 147 Lysozyme C Gallus gallus 1.29 76.72 82.22 yes 53.15 HCl-glycine 0.2 M DSC Thermal 2.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17796 55 147 Lysozyme C Gallus gallus 1.4 99.9 95.36 yes 53.65 HCl-glycine 0.2 M DSC Thermal 2.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17797 55 147 Lysozyme C Gallus gallus 2.72 88.67 90.34 yes 56.15 HCl-glycine 0.2 M DSC Thermal 2.6 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17798 55 147 Lysozyme C Gallus gallus 1.2 84.61 90.34 yes 56.35 HCl-glycine 0.2 M DSC Thermal 2.6 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17799 55 147 Lysozyme C Gallus gallus 3.39 94.89 95.6 yes 56.65 HCl-glycine 0.2 M DSC Thermal 2.6 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17800 55 147 Lysozyme C Gallus gallus 1.96 98.71 94.41 yes 56.65 HCl-glycine 0.2 M DSC Thermal 2.6 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17801 55 147 Lysozyme C Gallus gallus 1.73 90.11 92.73 yes 56.65 HCl-glycine 0.2 M DSC Thermal 2.7 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17802 55 147 Lysozyme C Gallus gallus 2.39 97.51 95.6 yes 56.65 HCl-glycine 0.2 M DSC Thermal 2.6 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17803 55 147 Lysozyme C Gallus gallus 2.24 94.41 90.82 yes 56.65 HCl-glycine 0.2 M DSC Thermal 2.6 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17804 55 147 Lysozyme C Gallus gallus 2.8 81.5 90.11 yes 56.95 HCl-glycine 0.2 M DSC Thermal 2.6 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17805 55 147 Lysozyme C Gallus gallus 1.81 81.98 90.58 yes 57.45 HCl-glycine 0.2 M DSC Thermal 2.6 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17806 55 147 Lysozyme C Gallus gallus 0.22 93.93 96.08 yes 58.15 HCl-glycine 0.2 M DSC Thermal 2.7 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17807 55 147 Lysozyme C Gallus gallus 0.44 115.92 103.49 yes 58.35 HCl-glycine 0.2 M DSC Thermal 2.6 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17808 55 147 Lysozyme C Gallus gallus 0.76 97.75 98.23 yes 58.95 HCl-glycine 0.2 M DSC Thermal 2.7 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17809 55 147 Lysozyme C Gallus gallus 0.77 92.5 93.45 yes 59.65 HCl-glycine 0.2 M DSC Thermal 2.6 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17810 55 147 Lysozyme C Gallus gallus 0.33 114.96 104.21 yes 60.15 HCl-glycine 0.2 M DSC Thermal 2.8 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17811 55 147 Lysozyme C Gallus gallus 0.58 100.38 99.19 yes 60.45 HCl-glycine 0.2 M DSC Thermal 2.6 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17812 55 147 Lysozyme C Gallus gallus 0.75 92.26 93.69 yes 60.65 HCl-glycine 0.2 M DSC Thermal 2.6 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17813 55 147 Lysozyme C Gallus gallus 0.74 89.15 93.69 yes 60.85 HCl-glycine 0.2 M DSC Thermal 2.6 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17814 55 147 Lysozyme C Gallus gallus 1.14 105.4 102.29 yes 60.85 HCl-glycine 0.2 M DSC Thermal 2.6 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17815 55 147 Lysozyme C Gallus gallus 1.46 104.92 104.45 yes 61.55 HCl-glycine 0.2 M DSC Thermal 2.6 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17816 55 147 Lysozyme C Gallus gallus 0.65 94.17 99.43 yes 61.65 HCl-glycine 0.2 M DSC Thermal 2.6 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17817 55 147 Lysozyme C Gallus gallus 0.65 92.26 97.28 yes 61.65 HCl-glycine 0.2 M DSC Thermal 2.6 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17818 55 147 Lysozyme C Gallus gallus 1.46 98.47 100.38 yes 61.85 HCl-glycine 0.2 M DSC Thermal 2.6 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17819 55 147 Lysozyme C Gallus gallus 0.0 88.43 96.8 yes 62.15 HCl-glycine 0.2 M DSC Thermal 2.6 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17820 55 147 Lysozyme C Gallus gallus 1.18 92.73 98.95 yes 62.35 HCl-glycine 0.2 M DSC Thermal 2.6 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17821 55 147 Lysozyme C Gallus gallus 0.33 98.47 101.58 yes 62.65 HCl-glycine 0.2 M DSC Thermal 2.6 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17822 55 147 Lysozyme C Gallus gallus 1.18 111.38 105.4 yes 63.15 HCl-glycine 0.2 M DSC Thermal 3.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17823 55 147 Lysozyme C Gallus gallus 1.77 108.03 103.25 yes 63.55 HCl-glycine 0.2 M DSC Thermal 3.1 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17824 55 147 Lysozyme C Gallus gallus 2.58 88.91 97.99 yes 64.05 HCl-glycine 0.2 M DSC Thermal 3.2 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17825 55 147 Lysozyme C Gallus gallus 1.73 108.27 104.68 yes 65.15 HCl-glycine 0.2 M DSC Thermal 3.3 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17826 55 147 Lysozyme C Gallus gallus 1.69 115.68 108.99 yes 65.75 HCl-glycine 0.2 M DSC Thermal 3.1 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17827 55 147 Lysozyme C Gallus gallus 1.4 106.6 106.84 yes 67.15 HCl-glycine 0.2 M DSC Thermal 3.2 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17828 55 147 Lysozyme C Gallus gallus 1.15 109.7 110.42 yes 69.15 HCl-glycine 0.2 M DSC Thermal 3.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17829 55 147 Lysozyme C Gallus gallus 2.05 127.15 116.16 yes 70.85 HCl-glycine 0.2 M DSC Thermal 3.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17830 55 147 Lysozyme C Gallus gallus 1.77 122.61 114.48 yes 70.95 HCl-glycine 0.2 M DSC Thermal 3.6 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17831 55 147 Lysozyme C Gallus gallus 1.56 127.87 117.11 yes 72.55 HCl-glycine 0.2 M DSC Thermal 3.6 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17832 55 147 Lysozyme C Gallus gallus 0.97 117.11 114.96 yes 72.75 HCl-glycine 0.2 M DSC Thermal 3.7 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17833 55 147 Lysozyme C Gallus gallus 4.8 114.24 117.83 yes 73.35 HCl-glycine 0.2 M DSC Thermal 3.7 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17834 55 147 Lysozyme C Gallus gallus 2.84 112.57 115.44 yes 73.55 HCl-glycine 0.2 M DSC Thermal 3.7 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17835 55 147 Lysozyme C Gallus gallus 1.6 114.72 116.16 yes 73.85 HCl-glycine 0.2 M DSC Thermal 3.7 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17836 55 147 Lysozyme C Gallus gallus 2.8 123.57 120.94 yes 73.85 HCl-glycine 0.2 M DSC Thermal 3.8 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17837 55 147 Lysozyme C Gallus gallus 2.24 105.4 112.33 yes 73.85 HCl-glycine 0.2 M DSC Thermal 3.7 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17838 55 147 Lysozyme C Gallus gallus 1.1 130.02 121.18 yes 74.05 HCl-glycine 0.2 M DSC Thermal 3.7 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17839 55 147 Lysozyme C Gallus gallus 2.09 126.2 119.74 yes 74.45 HCl-glycine 0.2 M DSC Thermal 3.8 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17840 55 147 Lysozyme C Gallus gallus 3.9 120.46 118.79 yes 74.95 HCl-glycine 0.2 M DSC Thermal 3.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17841 55 147 Lysozyme C Gallus gallus 1.68 110.42 117.11 yes 75.55 HCl-glycine 0.2 M DSC Thermal 3.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17842 55 147 Lysozyme C Gallus gallus 0.73 94.17 82.22 yes 52.65 HCl-glycine 0.1 M DSC Thermal 2.2 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17843 55 147 Lysozyme C Gallus gallus 2.36 113.29 111.38 yes 56.85 HCl-glycine 0.1 M DSC Thermal 2.3 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17844 55 147 Lysozyme C Gallus gallus 1.98 113.77 114.96 yes 75.65 HCl-glycine 0.1 M DSC Thermal 3.8 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17845 55 147 Lysozyme C Gallus gallus 1.39 103.49 101.34 yes 61.15 HCl-glycine 0.2 M DSC Thermal 3.3 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17846 55 147 Lysozyme C Gallus gallus 5.83 105.16 107.79 yes 63.05 HCl-glycine 0.2 M DSC Thermal 3.3 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17847 55 147 Lysozyme C Gallus gallus 4.02 123.33 125.72 yes 69.15 phosphoric acid-sodium phosphate 0.2 M DSC Thermal 3.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17848 55 147 Lysozyme C Gallus gallus 4.25 116.4 115.68 yes 72.35 phosphoric acid-sodium phosphate 0.2 M DSC Thermal 3.6 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 17849 55 147 Lysozyme C Gallus gallus 1.96 117.35 130.98 yes 76.95 phosphoric acid-sodium phosphate 0.2 M DSC Thermal 4.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf DOI: 10.1016/0040-6031(89)85164-0 ProTherm 18023 55 147 Lysozyme C Gallus gallus 1.48 117.11 yes 72.5 glycine 0.05 M DSC Thermal 3.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1446966 10.1111/j.1399-3011.1992.tb01456.x 1992 ProTherm 18117 55 147 Lysozyme C Gallus gallus yes 74.0 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8535242 10.1002/pro.5560041011 1995 ProTherm 18301 55 147 Lysozyme C Gallus gallus 102.5 Unknown 55.0 Unknown DSC Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8364147 10.1016/0301-4622(93)80030-m 1993 ProTherm 18349 55 147 Lysozyme C Gallus gallus 1.64 140.0 Unknown 79.0 acetate 30 mM DSC Thermal 4.6 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1322462 10.1016/0022-2836(92)90963-k 1992 ProTherm 18350 55 147 Lysozyme C Gallus gallus 1.55 91.2 89.5 yes 52.0 glycine 0.04 M DSC Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 427107 10.1021/bi00574a010 1979 ProTherm 18430 55 147 Lysozyme C Gallus gallus yes 61.0 Sodium phosphate 0.01 M NaCl 0.15 M CD Thermal 7.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 2125474 10.1021/bi00491a010 1990 ProTherm 18431 55 147 Lysozyme C Gallus gallus yes 48.7 Sodium phosphate 0.01 M NaCl 0.15 M CD Thermal 7.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 2125474 10.1021/bi00491a010 1990 ProTherm 18432 55 147 Lysozyme C Gallus gallus yes 57.9 Sodium phosphate 0.01 M NaCl 0.15 M CD Thermal 7.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 2125474 10.1021/bi00491a010 1990 ProTherm 19338 55 147 Lysozyme C Gallus gallus yes 74.3 Unknown CD Thermal 3.8 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9990012 10.1073/pnas.96.4.1262 1999 ProTherm 19393 55 147 Lysozyme C Gallus gallus 1.51 129.19 Unknown 77.5 glycine-HCl 50 mM DSC Thermal 3.8 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1613799 10.1016/0022-2836(92)90094-z 1992 ProTherm 19693 55 147 Lysozyme C Gallus gallus yes 74.8 Potassium phosphate 66 mM CD Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10813830 2000 ProTherm 19722 55 147 Lysozyme C Gallus gallus yes 65.6 glycine-HCl 50 mM DSC Thermal 2.7 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10964991 10.1093/oxfordjournals.protein.a029827 2000 ProTherm 19725 55 147 Lysozyme C Gallus gallus Unknown 68.2 Sodium acetate 0.1 M DSC Thermal 3.1 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10653703 10.1006/jmbi.1999.3442 2000 ProTherm 19726 55 147 Lysozyme C Gallus gallus Unknown 59.5 Sodium acetate 0.1 M DSC Thermal 3.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10653703 10.1006/jmbi.1999.3442 2000 ProTherm 19727 55 147 Lysozyme C Gallus gallus Unknown 39.6 Sodium acetate 0.1 M DSC Thermal 3.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10653703 10.1006/jmbi.1999.3442 2000 ProTherm 19728 55 147 Lysozyme C Gallus gallus Unknown 75.9 Sodium acetate 0.1 M DSC Thermal 3.7 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10653703 10.1006/jmbi.1999.3442 2000 ProTherm 19729 55 147 Lysozyme C Gallus gallus Unknown 68.7 Sodium acetate 0.1 M DSC Thermal 4.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10653703 10.1006/jmbi.1999.3442 2000 ProTherm 19730 55 147 Lysozyme C Gallus gallus Unknown 48.8 Sodium acetate 0.1 M DSC Thermal 4.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10653703 10.1006/jmbi.1999.3442 2000 ProTherm 20289 55 147 Lysozyme C Gallus gallus 3.69 10.4 yes potassium phosphate 0.05 M 35.0 Fluorescence GdnHCl 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8771183 10.1093/protein/8.10.1023 1995 ProTherm 20290 55 147 Lysozyme C Gallus gallus 3.62 10.1 2.9 yes acetate 0.1 M 35.0 CD GdnHCl 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8475043 10.1093/protein/6.2.183 1993 ProTherm 20291 55 147 Lysozyme C Gallus gallus 2.71 7.34 2.71 Unknown Sodium acetate 0.1 M 35.0 CD GdnHCl 3.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1420152 10.1021/bi00157a021 1992 ProTherm 20292 55 147 Lysozyme C Gallus gallus 3.26 8.83 2.71 Unknown Sodium acetate 0.1 M 35.0 CD GdnHCl 4.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1420152 10.1021/bi00157a021 1992 ProTherm 20293 55 147 Lysozyme C Gallus gallus 3.69 9.99 2.71 Unknown Sodium acetate 0.1 M 35.0 CD GdnHCl 4.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1420152 10.1021/bi00157a021 1992 ProTherm 20294 55 147 Lysozyme C Gallus gallus 3.63 9.84 2.71 Unknown Sodium acetate 0.1 M 35.0 CD GdnHCl 5.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1420152 10.1021/bi00157a021 1992 ProTherm 20295 55 147 Lysozyme C Gallus gallus 3.61 9.78 2.71 Unknown Sodium acetate 0.1 M 35.0 CD GdnHCl 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1420152 10.1021/bi00157a021 1992 ProTherm 20296 55 147 Lysozyme C Gallus gallus 2.71 7.02 2.59 Unknown Sodium acetate 0.1 M 35.0 CD GdnHCl 3.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1390669 10.1021/bi00152a018 1992 ProTherm 20297 55 147 Lysozyme C Gallus gallus 3.26 8.44 2.59 Unknown Sodium acetate 0.1 M 35.0 CD GdnHCl 4.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1390669 10.1021/bi00152a018 1992 ProTherm 20298 55 147 Lysozyme C Gallus gallus 3.69 9.56 2.59 Unknown Sodium acetate 0.1 M 35.0 CD GdnHCl 4.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1390669 10.1021/bi00152a018 1992 ProTherm 20299 55 147 Lysozyme C Gallus gallus 3.63 9.4 2.59 Unknown Sodium acetate 0.1 M 35.0 CD GdnHCl 5.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1390669 10.1021/bi00152a018 1992 ProTherm 20300 55 147 Lysozyme C Gallus gallus 3.61 9.35 2.59 Unknown Sodium acetate 0.1 M 35.0 CD GdnHCl 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1390669 10.1021/bi00152a018 1992 ProTherm 20301 55 147 Lysozyme C Gallus gallus 2.71 7.02 2.59 yes Sodium acetate 0.1 M 35.0 Fluorescence GdnHCl 3.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1610799 10.1021/bi00139a017 1992 ProTherm 20302 55 147 Lysozyme C Gallus gallus 3.26 8.44 2.59 yes Sodium acetate 0.1 M 35.0 Fluorescence GdnHCl 4.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1610799 10.1021/bi00139a017 1992 ProTherm 20303 55 147 Lysozyme C Gallus gallus 3.69 9.56 2.59 yes Sodium acetate 0.1 M 35.0 Fluorescence GdnHCl 4.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1610799 10.1021/bi00139a017 1992 ProTherm 20304 55 147 Lysozyme C Gallus gallus 3.63 9.4 2.59 yes Sodium acetate 0.1 M 35.0 Fluorescence GdnHCl 5.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1610799 10.1021/bi00139a017 1992 ProTherm 20305 55 147 Lysozyme C Gallus gallus 3.61 9.35 2.59 yes Sodium acetate 0.1 M 35.0 Fluorescence GdnHCl 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1610799 10.1021/bi00139a017 1992 ProTherm 20306 55 147 Lysozyme C Gallus gallus 3.62 9.8 2.7 yes acetate 0.1 M 35.0 Fluorescence GdnHCl 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8720127 10.1093/oxfordjournals.jbchem.a124999 1995 ProTherm 20490 55 147 Lysozyme C Gallus gallus 1.5 3.6 1.7 yes Sodium phosphate 0.01 M 25.0 NaCl 0.15 M CD Thermal 7.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 2125474 10.1021/bi00491a010 1990 ProTherm 20491 55 147 Lysozyme C Gallus gallus 1.5 5.0 48.8 yes Sodium phosphate 0.01 M 25.0 NaCl 0.15 M CD Thermal 7.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 2125474 10.1021/bi00491a010 1990 ProTherm 20492 55 147 Lysozyme C Gallus gallus 1.5 4.8 24.4 yes Sodium phosphate 0.01 M 25.0 NaCl 0.15 M CD Thermal 7.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 2125474 10.1021/bi00491a010 1990 ProTherm 20570 55 147 Lysozyme C Gallus gallus 10.99 yes glycine 0.05 M 25.0 DSC Thermal 3.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1446966 10.1111/j.1399-3011.1992.tb01456.x 1992 ProTherm 20571 55 147 Lysozyme C Gallus gallus 9.01 yes(>90%) glycine 0.04 M 25.0 DSC Thermal 1.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4368360 10.1016/0022-2836(74)90188-0 1974 ProTherm 20572 55 147 Lysozyme C Gallus gallus 17.59 yes(>90%) glycine 0.04 M 25.0 DSC Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4368360 10.1016/0022-2836(74)90188-0 1974 ProTherm 20595 55 147 Lysozyme C Gallus gallus 4.12 10.2 2.4 yes Sodium acetate 0.1 M 25.0 CD GdnHCl 5.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8535241 10.1002/pro.5560041010 1995 ProTherm 20938 55 147 Lysozyme C Gallus gallus 2.06 4.18 2.03 yes HCl 25.0 KCl 0.1-1.0 M Absorbance GdnHCl 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10029541 10.1021/bi982078m 1999 ProTherm 20939 55 147 Lysozyme C Gallus gallus 3.32 4.09 1.23 yes HCl 25.0 KCl 0.1 M Absorbance Urea 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10029541 10.1021/bi982078m 1999 ProTherm 20940 55 147 Lysozyme C Gallus gallus 3.98 4.38 1.1 yes HCl 25.0 KCl 0.30-0.50 M Absorbance Urea 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10029541 10.1021/bi982078m 1999 ProTherm 20941 55 147 Lysozyme C Gallus gallus 4.68 5.29 1.13 yes HCl 25.0 KCl 0.75-1.00 M Absorbance Urea 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10029541 10.1021/bi982078m 1999 ProTherm 20942 55 147 Lysozyme C Gallus gallus 2.33 2.56 1.1 yes HCl 25.0 KCl 0.1 M Absorbance Urea 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10029541 10.1021/bi982078m 1999 ProTherm 20943 55 147 Lysozyme C Gallus gallus 1.72 1.72 1.0 yes HCl 25.0 KCl 0.1 M Absorbance Urea 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10029541 10.1021/bi982078m 1999 ProTherm 20944 55 147 Lysozyme C Gallus gallus 0.66 0.7 1.06 yes HCl 25.0 KCl 0.1 M Absorbance Urea 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10029541 10.1021/bi982078m 1999 ProTherm 20945 55 147 Lysozyme C Gallus gallus 0.27 0.3 1.12 yes HCl 25.0 KCl 0.1 M Absorbance Urea 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10029541 10.1021/bi982078m 1999 ProTherm 21210 55 147 Lysozyme C Gallus gallus 12.92 Unknown glycine-HCl 50 mM 25.0 DSC Thermal 3.8 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1613799 10.1016/0022-2836(92)90094-z 1992 ProTherm 21273 55 147 Lysozyme C Gallus gallus 4.21 8.89 2.11 yes Unknown 25.0 KCl 0.1 M Absorbance GdnHCl 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1445206 10.1042/bj2870481 1992 ProTherm 21274 55 147 Lysozyme C Gallus gallus 4.05 8.58 2.11 yes Unknown 25.0 KCl 0.1 M Absorbance GdnHCl 6.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1445206 10.1042/bj2870481 1992 ProTherm 21275 55 147 Lysozyme C Gallus gallus 2.13 4.08 1.91 yes Unknown 25.0 KCl 0.1 M Absorbance GdnHCl 2.03 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1445206 10.1042/bj2870481 1992 ProTherm 21276 55 147 Lysozyme C Gallus gallus 1.59 2.72 1.71 yes Unknown 25.0 KCl 0.1 M Absorbance GdnHCl 0.64 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1445206 10.1042/bj2870481 1992 ProTherm 21277 55 147 Lysozyme C Gallus gallus 1.52 2.61 1.71 yes Unknown 25.0 KCl 0.1 M Absorbance GdnHCl 0.34 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1445206 10.1042/bj2870481 1992 ProTherm 21602 55 147 Lysozyme C Gallus gallus 12.67 Unknown sodium carbonate 50 mM 20.0 CD Thermal 9.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7664875 10.1016/0014-5793(95)00846-2 1995 ProTherm 21659 55 147 Lysozyme C Gallus gallus 11.09 2.63 Unknown NaOAc 20 mM 20.0 CD GdnHCl 5.2 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10493816 10.1021/bi9909703 1999 ProTherm 21660 55 147 Lysozyme C Gallus gallus 11.83 2.8 Unknown NaOAc 20 mM 20.0 NaCl 0.85 M CD GdnHCl 5.2 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10493816 10.1021/bi9909703 1999 ProTherm 21893 55 147 Lysozyme C Gallus gallus 20.0 Unknown Unknown 20.0 Absorbance LiCl 5.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4672958 10.1016/0022-2836(72)90544-x 1972 ProTherm 21956 55 147 Lysozyme C Gallus gallus 12.31 2.77 Unknown NaOAc 20 mM 10.0 NaCl 0.85 M CD GdnHCl 5.2 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 10493816 10.1021/bi9909703 1999 ProTherm 22107 55 147 Lysozyme C Gallus gallus Unknown 66.0 glycine hydrochloride 0.05 M DSC Thermal 2.7 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 11266617 10.1110/ps.37401 2001 ProTherm 22161 55 147 Lysozyme C Gallus gallus 129.78 Yes 86.0 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22162 55 147 Lysozyme C Gallus gallus 128.82 Yes 86.2 Cacodylic acid 0.05 M KCl 0.1 M CD Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22163 55 147 Lysozyme C Gallus gallus 1.6 126.91 Yes 83.0 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22164 55 147 Lysozyme C Gallus gallus 1.64 123.33 Yes 79.5 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22165 55 147 Lysozyme C Gallus gallus 120.46 Yes 76.8 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22166 55 147 Lysozyme C Gallus gallus 118.55 Yes 73.8 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22167 55 147 Lysozyme C Gallus gallus 118.55 Yes 73.6 Cacodylic acid 0.05 M KCl 0.1 M CD Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22168 55 147 Lysozyme C Gallus gallus 133.84 Yes 87.1 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22169 55 147 Lysozyme C Gallus gallus 136.71 Yes 88.3 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22170 55 147 Lysozyme C Gallus gallus 140.77 Yes 90.0 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22171 55 147 Lysozyme C Gallus gallus 144.84 Yes 91.9 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22172 55 147 Lysozyme C Gallus gallus 146.75 Yes 91.7 Cacodylic acid 0.05 M KCl 0.1 M CD Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22173 55 147 Lysozyme C Gallus gallus 1.56 132.89 Yes 87.6 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22174 55 147 Lysozyme C Gallus gallus 1.6 136.95 Yes 88.3 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22175 55 147 Lysozyme C Gallus gallus 1.57 139.82 Yes 89.3 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22176 55 147 Lysozyme C Gallus gallus 1.59 142.69 Yes 90.0 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22177 55 147 Lysozyme C Gallus gallus 140.77 Yes 89.8 Cacodylic acid 0.05 M KCl 0.1 M CD Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22178 55 147 Lysozyme C Gallus gallus 1.59 128.82 Yes 84.0 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22179 55 147 Lysozyme C Gallus gallus 1.58 127.87 Yes 82.5 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22180 55 147 Lysozyme C Gallus gallus 1.52 125.0 Yes 81.0 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22181 55 147 Lysozyme C Gallus gallus 1.52 121.89 Yes 79.0 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22182 55 147 Lysozyme C Gallus gallus 122.85 Yes 79.1 Cacodylic acid 0.05 M KCl 0.1 M CD Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22183 55 147 Lysozyme C Gallus gallus 1.62 127.87 Yes 85.8 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22184 55 147 Lysozyme C Gallus gallus 1.62 125.0 Yes 83.7 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22185 55 147 Lysozyme C Gallus gallus 1.62 122.85 Yes 82.5 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22186 55 147 Lysozyme C Gallus gallus 1.6 121.18 Yes 81.0 Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22187 55 147 Lysozyme C Gallus gallus 119.98 Yes 81.2 Cacodylic acid 0.05 M KCl 0.1 M CD Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22215 55 147 Lysozyme C Gallus gallus 1.62 Yes Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22216 55 147 Lysozyme C Gallus gallus 1.61 Yes Cacodylic acid 0.05 M KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 22664 55 147 Lysozyme C Gallus gallus 3.27 93.52 yes 56.25 Sodium phosphate 50 mM KCl 0.5 M CD Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 12589765 10.1016/s0022-2836(02)01443-2 2003 ProTherm 22665 55 147 Lysozyme C Gallus gallus 1.96 89.36 yes 56.45 Sodium phosphate 50 mM KCl 0.5 M CD Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 12589765 10.1016/s0022-2836(02)01443-2 2003 ProTherm 22666 55 147 Lysozyme C Gallus gallus 2.29 97.44 yes 56.25 Sodium phosphate 50 mM KCl 0.5 M CD Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 12589765 10.1016/s0022-2836(02)01443-2 2003 ProTherm 22667 55 147 Lysozyme C Gallus gallus 4.37 94.81 yes 56.75 Sodium phosphate 50 mM KCl 0.5 M CD Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 12589765 10.1016/s0022-2836(02)01443-2 2003 ProTherm 22668 55 147 Lysozyme C Gallus gallus 4.57 99.19 yes 56.55 Sodium phosphate 50 mM KCl 0.5 M CD Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 12589765 10.1016/s0022-2836(02)01443-2 2003 ProTherm 22669 55 147 Lysozyme C Gallus gallus 3.97 96.1 yes 56.65 Sodium phosphate 50 mM KCl 0.5 M CD Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 12589765 10.1016/s0022-2836(02)01443-2 2003 ProTherm 22670 55 147 Lysozyme C Gallus gallus 2.2 92.57 yes 57.65 Sodium phosphate 50 mM KCl 0.5 M CD Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 12589765 10.1016/s0022-2836(02)01443-2 2003 ProTherm 22671 55 147 Lysozyme C Gallus gallus 2.56 95.63 yes 57.35 Sodium phosphate 50 mM KCl 0.5 M CD Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 12589765 10.1016/s0022-2836(02)01443-2 2003 ProTherm 22672 55 147 Lysozyme C Gallus gallus 1.82 94.17 yes 58.55 Sodium phosphate 50 mM KCl 0.5 M CD Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 12589765 10.1016/s0022-2836(02)01443-2 2003 ProTherm 22673 55 147 Lysozyme C Gallus gallus 0.17 96.51 yes 58.75 Sodium phosphate 50 mM KCl 0.5 M CD Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 12589765 10.1016/s0022-2836(02)01443-2 2003 ProTherm 22674 55 147 Lysozyme C Gallus gallus 0.19 90.56 yes 59.35 Sodium phosphate 50 mM KCl 0.5 M CD Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 12589765 10.1016/s0022-2836(02)01443-2 2003 ProTherm 22675 55 147 Lysozyme C Gallus gallus 3.18 98.61 yes 59.05 Sodium phosphate 50 mM KCl 0.5 M CD Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 12589765 10.1016/s0022-2836(02)01443-2 2003 ProTherm 22676 55 147 Lysozyme C Gallus gallus 4.13 97.87 yes 58.65 Sodium phosphate 50 mM KCl 0.5 M CD Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 12589765 10.1016/s0022-2836(02)01443-2 2003 ProTherm 22677 55 147 Lysozyme C Gallus gallus 1.03 95.6 yes 59.25 Sodium phosphate 50 mM KCl 0.5 M CD Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 12589765 10.1016/s0022-2836(02)01443-2 2003 ProTherm 22678 55 147 Lysozyme C Gallus gallus 3.56 95.72 yes 59.05 Sodium phosphate 50 mM KCl 0.5 M CD Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 12589765 10.1016/s0022-2836(02)01443-2 2003 ProTherm 22679 55 147 Lysozyme C Gallus gallus 0.86 98.59 yes 58.95 Sodium phosphate 50 mM KCl 0.5 M CD Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 12589765 10.1016/s0022-2836(02)01443-2 2003 ProTherm 23092 55 147 Lysozyme C Gallus gallus 117.11 Yes 74.3 Sodium citrate 11 mM DSC Thermal 6.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 15741330 10.1110/ps.041085005 2005 ProTherm 23093 55 147 Lysozyme C Gallus gallus 112.09 Yes 73.7 Sodium citrate 11 mM DSC Thermal 6.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 15741330 10.1110/ps.041085005 2005 ProTherm 23094 55 147 Lysozyme C Gallus gallus 108.03 Yes 73.9 Sodium citrate 11 mM DSC Thermal 6.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 15741330 10.1110/ps.041085005 2005 ProTherm 23224 55 147 Lysozyme C Gallus gallus Unknown 77.7 Phosphate 10 mM DSC Thermal 7.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16834343 10.1021/bi060525p 2006 ProTherm 23225 55 147 Lysozyme C Gallus gallus Unknown 73.2 Phosphate 10 mM DSC Thermal 4.2 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16834343 10.1021/bi060525p 2006 ProTherm 23234 55 147 Lysozyme C Gallus gallus Unknown 75.0 Phosphate 10 mM Absorbance Thermal 7.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16834343 10.1021/bi060525p 2006 ProTherm 23235 55 147 Lysozyme C Gallus gallus Unknown 73.3 Phosphate 10 mM Absorbance Thermal 4.2 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16834343 10.1021/bi060525p 2006 ProTherm 23243 55 147 Lysozyme C Gallus gallus Unknown 69.3 Phosphate 10 mM Optical Density Thermal 4.2 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16834343 10.1021/bi060525p 2006 ProTherm 23251 55 147 Lysozyme C Gallus gallus Unknown 80.0 Phosphate 10 mM Fluorescence Thermal 7.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16834343 10.1021/bi060525p 2006 ProTherm 23252 55 147 Lysozyme C Gallus gallus Unknown 75.0 Phosphate 10 mM Fluorescence Thermal 4.2 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16834343 10.1021/bi060525p 2006 ProTherm 23259 55 147 Lysozyme C Gallus gallus Unknown 80.0 Phosphate 10 mM CD Thermal 7.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16834343 10.1021/bi060525p 2006 ProTherm 23260 55 147 Lysozyme C Gallus gallus Unknown 74.0 Phosphate 10 mM CD Thermal 4.2 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16834343 10.1021/bi060525p 2006 ProTherm 23584 55 147 Lysozyme C Gallus gallus 170.36 unknown 74.25 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23585 55 147 Lysozyme C Gallus gallus 196.63 unknown 76.65 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23586 55 147 Lysozyme C Gallus gallus 215.75 unknown 78.95 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23587 55 147 Lysozyme C Gallus gallus 196.77 unknown 81.35 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23588 55 147 Lysozyme C Gallus gallus 229.06 unknown 84.05 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23589 55 147 Lysozyme C Gallus gallus 183.27 unknown 74.25 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23590 55 147 Lysozyme C Gallus gallus 179.85 unknown 77.65 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23591 55 147 Lysozyme C Gallus gallus 199.35 unknown 80.35 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23592 55 147 Lysozyme C Gallus gallus 224.16 unknown 82.45 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23593 55 147 Lysozyme C Gallus gallus 134.06 unknown 76.35 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23594 55 147 Lysozyme C Gallus gallus 137.67 unknown 78.65 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23595 55 147 Lysozyme C Gallus gallus 161.66 unknown 80.05 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23596 55 147 Lysozyme C Gallus gallus 184.85 unknown 81.15 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23597 55 147 Lysozyme C Gallus gallus 223.09 unknown 75.65 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23598 55 147 Lysozyme C Gallus gallus 197.94 unknown 77.75 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23599 55 147 Lysozyme C Gallus gallus 190.82 unknown 80.25 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23600 55 147 Lysozyme C Gallus gallus 225.17 unknown 80.25 Acetic acid-Sodium acetate 0.04 M Absorbance Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17581805 10.1016/j.bbapap.2007.05.008 2007 ProTherm 23683 55 147 Lysozyme C Gallus gallus 1.55 112.81 Yes 77.05 Acetate 50 mM DSC Thermal 4.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17143859 10.1002/bip.20645 2007 ProTherm 23684 55 147 Lysozyme C Gallus gallus 110.66 Yes 77.05 Acetate 50 mM DSC Thermal 4.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17143859 10.1002/bip.20645 2007 ProTherm 23685 55 147 Lysozyme C Gallus gallus 111.14 Yes 76.45 Acetate 50 mM DSC Thermal 5.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17143859 10.1002/bip.20645 2007 ProTherm 23686 55 147 Lysozyme C Gallus gallus 108.27 Yes 75.65 Acetate 50 mM DSC Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17143859 10.1002/bip.20645 2007 ProTherm 23687 55 147 Lysozyme C Gallus gallus 107.07 Yes 74.05 Phosphate 50 mM DSC Thermal 6.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17143859 10.1002/bip.20645 2007 ProTherm 23688 55 147 Lysozyme C Gallus gallus 105.16 Yes 73.05 Phosphate 50 mM DSC Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17143859 10.1002/bip.20645 2007 ProTherm 23689 55 147 Lysozyme C Gallus gallus 1.7 130.02 Yes 79.95 Acetate 50 mM DSC Thermal 4.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17143859 10.1002/bip.20645 2007 ProTherm 23690 55 147 Lysozyme C Gallus gallus 126.67 Yes 79.15 Acetate 50 mM DSC Thermal 4.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17143859 10.1002/bip.20645 2007 ProTherm 23691 55 147 Lysozyme C Gallus gallus 125.24 Yes 78.85 Acetate 50 mM DSC Thermal 5.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17143859 10.1002/bip.20645 2007 ProTherm 23692 55 147 Lysozyme C Gallus gallus 123.09 Yes 76.65 Phosphate 50 mM DSC Thermal 6.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17143859 10.1002/bip.20645 2007 ProTherm 23798 55 147 Lysozyme C Gallus gallus 2.71 89.87 Yes 59.3 KCl-HCl 0.1 M CD Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 18201812 10.1016/j.bpc.2007.12.006 2008 ProTherm 23801 55 147 Lysozyme C Gallus gallus 2.69 88.91 Yes 60.0 KCl-HCl 0.1 M CD Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 18201812 10.1016/j.bpc.2007.12.006 2008 ProTherm 23808 55 147 Lysozyme C Gallus gallus 48.04 Yes 38.5 KCl-HCl 0.1 M CD Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 18201812 10.1016/j.bpc.2007.12.006 2008 ProTherm 23809 55 147 Lysozyme C Gallus gallus 40.87 Yes 36.1 KCl-HCl 0.1 M CD Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 18201812 10.1016/j.bpc.2007.12.006 2008 ProTherm 23810 55 147 Lysozyme C Gallus gallus 34.89 Yes 33.5 KCl-HCl 0.1 M CD Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 18201812 10.1016/j.bpc.2007.12.006 2008 ProTherm 23811 55 147 Lysozyme C Gallus gallus 28.92 Yes 31.7 KCl-HCl 0.1 M CD Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 18201812 10.1016/j.bpc.2007.12.006 2008 ProTherm 23820 55 147 Lysozyme C Gallus gallus 65.01 Yes 38.5 KCl-HCl 0.1 M CD Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 18201812 10.1016/j.bpc.2007.12.006 2008 ProTherm 23821 55 147 Lysozyme C Gallus gallus 61.9 Yes 35.4 KCl-HCl 0.1 M CD Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 18201812 10.1016/j.bpc.2007.12.006 2008 ProTherm 23822 55 147 Lysozyme C Gallus gallus 56.88 Yes 32.6 KCl-HCl 0.1 M CD Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 18201812 10.1016/j.bpc.2007.12.006 2008 ProTherm 23823 55 147 Lysozyme C Gallus gallus 51.86 Yes 28.6 KCl-HCl 0.1 M CD Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 18201812 10.1016/j.bpc.2007.12.006 2008 ProTherm 24029 55 147 Lysozyme C Gallus gallus 183.27 Unknown 74.25 Acetate 0.04 M Absorbance Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24030 55 147 Lysozyme C Gallus gallus 179.85 Unknown 77.65 Acetate 0.04 M Absorbance Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24031 55 147 Lysozyme C Gallus gallus 199.35 Unknown 80.35 Acetate 0.04 M Absorbance Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24032 55 147 Lysozyme C Gallus gallus 224.16 Unknown 82.45 Acetate 0.04 M Absorbance Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24033 55 147 Lysozyme C Gallus gallus 196.63 Unknown 76.65 Acetate 0.04 M Absorbance Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24034 55 147 Lysozyme C Gallus gallus 215.75 Unknown 78.95 Acetate 0.04 M Absorbance Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24035 55 147 Lysozyme C Gallus gallus 198.92 Unknown 81.35 Acetate 0.04 M Absorbance Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24036 55 147 Lysozyme C Gallus gallus 229.06 Unknown 84.05 Acetate 0.04 M Absorbance Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24037 55 147 Lysozyme C Gallus gallus 223.09 Unknown 75.65 Acetate 0.04 M Absorbance Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24038 55 147 Lysozyme C Gallus gallus 197.94 Unknown 77.75 Acetate 0.04 M Absorbance Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24039 55 147 Lysozyme C Gallus gallus 190.82 Unknown 80.25 Acetate 0.04 M Absorbance Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24040 55 147 Lysozyme C Gallus gallus 225.17 Unknown 80.25 Acetate 0.04 M Absorbance Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24041 55 147 Lysozyme C Gallus gallus 189.36 Unknown 72.95 Acetate 0.04 M Absorbance Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24042 55 147 Lysozyme C Gallus gallus 144.41 Unknown 72.15 Acetate 0.04 M Absorbance Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24043 55 147 Lysozyme C Gallus gallus 160.68 Unknown 70.55 Acetate 0.04 M Absorbance Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24044 55 147 Lysozyme C Gallus gallus 143.64 Unknown 69.45 Acetate 0.04 M Absorbance Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24045 55 147 Lysozyme C Gallus gallus 202.06 Unknown 68.05 Acetate 0.04 M Absorbance Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24046 55 147 Lysozyme C Gallus gallus 186.11 Unknown 64.85 Acetate 0.04 M Absorbance Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24047 55 147 Lysozyme C Gallus gallus 133.44 Unknown 62.95 Acetate 0.04 M Absorbance Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 24048 55 147 Lysozyme C Gallus gallus 91.2 Unknown 61.45 Acetate 0.04 M Absorbance Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 19573978 10.1016/j.bpc.2009.06.004 2009 ProTherm 25046 55 147 Lysozyme C Gallus gallus yes 2.0 57.5 KCl-HCl 100000.0 UV?visible spectrophotometer Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 31760012 10.1016/j.ijbiomac.2019.10.135 2020 ProTherm 25047 55 147 Lysozyme C Gallus gallus yes 2.0 57.9 KCl-HCl 100000.0 UV?visible spectrophotometer Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 31760012 10.1016/j.ijbiomac.2019.10.135 2020 ProTherm 25048 55 147 Lysozyme C Gallus gallus yes 2.0 58.4 KCl-HCl 100000.0 UV?visible spectrophotometer Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 31760012 10.1016/j.ijbiomac.2019.10.135 2020 ProTherm 25049 55 147 Lysozyme C Gallus gallus yes 2.0 59.8 KCl-HCl 100000.0 UV?visible spectrophotometer Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 31760012 10.1016/j.ijbiomac.2019.10.135 2020 ProTherm 25050 55 147 Lysozyme C Gallus gallus yes 2.0 61.4 KCl-HCl 100000.0 UV?visible spectrophotometer Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 31760012 10.1016/j.ijbiomac.2019.10.135 2020 ProTherm 25051 55 147 Lysozyme C Gallus gallus yes 2.0 61.9 KCl-HCl 100000.0 UV?visible spectrophotometer Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 31760012 10.1016/j.ijbiomac.2019.10.135 2020 ProTherm 25052 55 147 Lysozyme C Gallus gallus yes 2.0 60.4 KCl-HCl 100000.0 UV?visible spectrophotometer Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 31760012 10.1016/j.ijbiomac.2019.10.135 2020 ProTherm 25053 55 147 Lysozyme C Gallus gallus yes 2.0 63.1 KCl-HCl 100000.0 UV?visible spectrophotometer Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 31760012 10.1016/j.ijbiomac.2019.10.135 2020 ProTherm 25054 55 147 Lysozyme C Gallus gallus yes 2.0 85.6 KCL 100000.0 UV?visible spectrophotometer Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 31760012 10.1016/j.ijbiomac.2019.10.135 2020 ProTherm 25055 55 147 Lysozyme C Gallus gallus yes 2.0 85.7 KCL 100000.0 UV?visible spectrophotometer Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 31760012 10.1016/j.ijbiomac.2019.10.135 2020 ProTherm 25056 55 147 Lysozyme C Gallus gallus yes 2.0 85.9 KCL 100000.0 UV?visible spectrophotometer Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 31760012 10.1016/j.ijbiomac.2019.10.135 2020 ProTherm 25057 55 147 Lysozyme C Gallus gallus yes 2.0 87.0 KCL 100000.0 UV?visible spectrophotometer Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 31760012 10.1016/j.ijbiomac.2019.10.135 2020 ProTherm 25058 55 147 Lysozyme C Gallus gallus yes 2.0 87.2 KCL 100000.0 UV?visible spectrophotometer Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 31760012 10.1016/j.ijbiomac.2019.10.135 2020 ProTherm 25059 55 147 Lysozyme C Gallus gallus yes 2.0 88.3 KCL 100000.0 UV?visible spectrophotometer Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 31760012 10.1016/j.ijbiomac.2019.10.135 2020 ProTherm 25060 55 147 Lysozyme C Gallus gallus yes 2.0 89.9 KCL 100000.0 UV?visible spectrophotometer Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 31760012 10.1016/j.ijbiomac.2019.10.135 2020 ProTherm 25061 55 147 Lysozyme C Gallus gallus yes 2.0 63.8 KCl-HCl 100000.0 UV?visible spectrophotometer Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 31760012 10.1016/j.ijbiomac.2019.10.135 2020 ProTherm 25062 55 147 Lysozyme C Gallus gallus yes 2.0 65.4 KCl-HCl 100000.0 UV?visible spectrophotometer Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 31760012 10.1016/j.ijbiomac.2019.10.135 2020 ProTherm 25063 55 147 Lysozyme C Gallus gallus yes 2.0 67.3 KCl-HCl 100000.0 UV?visible spectrophotometer Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 31760012 10.1016/j.ijbiomac.2019.10.135 2020 ProTherm 25064 55 147 Lysozyme C Gallus gallus yes 2.0 68.6 KCl-HCl 100000.0 UV?visible spectrophotometer Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 31760012 10.1016/j.ijbiomac.2019.10.135 2020 ProTherm 25065 55 147 Lysozyme C Gallus gallus yes 2.0 60.1 KCl-HCl 100000.0 UV?visible spectrophotometer Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 31760012 10.1016/j.ijbiomac.2019.10.135 2020 ProTherm 25066 55 147 Lysozyme C Gallus gallus yes 2.0 63.3 KCl-HCl 100000.0 UV?visible spectrophotometer Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 31760012 10.1016/j.ijbiomac.2019.10.135 2020 ProTherm 25067 55 147 Lysozyme C Gallus gallus yes 2.0 65.7 KCl-HCl 100000.0 UV?visible spectrophotometer Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 31760012 10.1016/j.ijbiomac.2019.10.135 2020 ProTherm 25068 55 147 Lysozyme C Gallus gallus yes 2.0 67.6 KCl-HCl 100000.0 UV?visible spectrophotometer Thermal 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 31760012 10.1016/j.ijbiomac.2019.10.135 2020 ProTherm 25372 55 147 Lysozyme C Gallus gallus 3.4 Unknown sodium acetate 0.1 M 35.0 HCl Fluorescence GdnHCl 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 11477222 10.1093/protein/14.6.421 2001 ProTherm 25508 55 147 Lysozyme C Gallus gallus 10.3 Yes Acetate 50 mM 27.0 DSC Thermal 4.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17143859 10.1002/bip.20645 2007 ProTherm 25509 55 147 Lysozyme C Gallus gallus 9.99 Yes Acetate 50 mM 27.0 DSC Thermal 4.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17143859 10.1002/bip.20645 2007 ProTherm 25510 55 147 Lysozyme C Gallus gallus 10.01 Yes Acetate 50 mM 27.0 DSC Thermal 5.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17143859 10.1002/bip.20645 2007 ProTherm 25511 55 147 Lysozyme C Gallus gallus 9.58 Yes Acetate 50 mM 27.0 DSC Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17143859 10.1002/bip.20645 2007 ProTherm 25512 55 147 Lysozyme C Gallus gallus 9.87 Yes Phosphate 50 mM 27.0 DSC Thermal 6.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17143859 10.1002/bip.20645 2007 ProTherm 25513 55 147 Lysozyme C Gallus gallus 9.32 Yes Phosphate 50 mM 27.0 DSC Thermal 6.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17143859 10.1002/bip.20645 2007 ProTherm 25514 55 147 Lysozyme C Gallus gallus 9.01 Yes Phosphate 50 mM 27.0 DSC Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17143859 10.1002/bip.20645 2007 ProTherm 25515 55 147 Lysozyme C Gallus gallus 12.4 Yes Acetate 50 mM 27.0 DSC Thermal 4.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17143859 10.1002/bip.20645 2007 ProTherm 25516 55 147 Lysozyme C Gallus gallus 11.85 Yes Acetate 50 mM 27.0 DSC Thermal 4.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17143859 10.1002/bip.20645 2007 ProTherm 25517 55 147 Lysozyme C Gallus gallus 11.64 Yes Acetate 50 mM 27.0 DSC Thermal 5.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17143859 10.1002/bip.20645 2007 ProTherm 25518 55 147 Lysozyme C Gallus gallus 11.76 Yes Acetate 50 mM 27.0 DSC Thermal 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17143859 10.1002/bip.20645 2007 ProTherm 25519 55 147 Lysozyme C Gallus gallus 11.21 Yes Phosphate 50 mM 27.0 DSC Thermal 6.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17143859 10.1002/bip.20645 2007 ProTherm 25520 55 147 Lysozyme C Gallus gallus 10.68 Yes Phosphate 50 mM 27.0 DSC Thermal 7.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17143859 10.1002/bip.20645 2007 ProTherm 25577 55 147 Lysozyme C Gallus gallus 13.19 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25578 55 147 Lysozyme C Gallus gallus 13.22 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25579 55 147 Lysozyme C Gallus gallus 12.56 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25580 55 147 Lysozyme C Gallus gallus 11.79 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25581 55 147 Lysozyme C Gallus gallus 11.21 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25582 55 147 Lysozyme C Gallus gallus 10.74 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25583 55 147 Lysozyme C Gallus gallus 10.78 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25584 55 147 Lysozyme C Gallus gallus 13.87 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25585 55 147 Lysozyme C Gallus gallus 14.43 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25586 55 147 Lysozyme C Gallus gallus 15.19 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25587 55 147 Lysozyme C Gallus gallus 15.55 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25588 55 147 Lysozyme C Gallus gallus 15.52 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25589 55 147 Lysozyme C Gallus gallus 13.71 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25590 55 147 Lysozyme C Gallus gallus 15.0 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25591 55 147 Lysozyme C Gallus gallus 15.53 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25592 55 147 Lysozyme C Gallus gallus 15.49 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25593 55 147 Lysozyme C Gallus gallus 12.93 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25594 55 147 Lysozyme C Gallus gallus 12.71 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25595 55 147 Lysozyme C Gallus gallus 12.0 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25596 55 147 Lysozyme C Gallus gallus 11.61 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25597 55 147 Lysozyme C Gallus gallus 11.64 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25598 55 147 Lysozyme C Gallus gallus 12.81 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25599 55 147 Lysozyme C Gallus gallus 12.76 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25600 55 147 Lysozyme C Gallus gallus 11.9 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25601 55 147 Lysozyme C Gallus gallus 11.54 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M Absorbance Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 25602 55 147 Lysozyme C Gallus gallus 11.58 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 17962089 10.1016/j.bbapap.2007.09.006 2007 ProTherm 26016 55 147 Lysozyme C Gallus gallus 5.79 2.53 yes Unknown 25.0 KCl 0.6 M CD GdnHCl 2.2 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 12402357 10.1002/prot.10215 2002 ProTherm 26017 55 147 Lysozyme C Gallus gallus 4.84 2.48 yes Unknown 25.0 KCl 0.6 M CD GdnHCl 0.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 12402357 10.1002/prot.10215 2002 ProTherm 26018 55 147 Lysozyme C Gallus gallus 3.63 1.26 yes 3.0 Unknown 25.0 KCl 0.6 M CD GdnHCl 0.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 12402357 10.1002/prot.10215 2002 ProTherm 26019 55 147 Lysozyme C Gallus gallus 1.21 1.21 yes 3.0 Unknown 25.0 KCl 0.6 M CD GdnHCl 0.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 12402357 10.1002/prot.10215 2002 ProTherm 26143 55 147 Lysozyme C Gallus gallus 2.0 4.1 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 1.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26144 55 147 Lysozyme C Gallus gallus 2.0 4.09 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 1.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26145 55 147 Lysozyme C Gallus gallus 2.6 6.47 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26146 55 147 Lysozyme C Gallus gallus 3.9 11.91 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 4.8 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26147 55 147 Lysozyme C Gallus gallus 4.3 13.39 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 6.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26148 55 147 Lysozyme C Gallus gallus 2.4 4.69 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 1.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26149 55 147 Lysozyme C Gallus gallus 2.4 4.68 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 1.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26150 55 147 Lysozyme C Gallus gallus 2.9 7.33 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26151 55 147 Lysozyme C Gallus gallus 4.4 12.22 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 4.8 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26152 55 147 Lysozyme C Gallus gallus 4.8 13.84 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 6.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26153 55 147 Lysozyme C Gallus gallus 2.9 5.39 1.86 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 1.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26154 55 147 Lysozyme C Gallus gallus 3.3 8.49 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26155 55 147 Lysozyme C Gallus gallus 4.7 12.49 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 4.8 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26156 55 147 Lysozyme C Gallus gallus 5.3 13.68 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 6.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26157 55 147 Lysozyme C Gallus gallus 3.4 6.21 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 1.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26158 55 147 Lysozyme C Gallus gallus 3.7 9.34 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26159 55 147 Lysozyme C Gallus gallus 5.2 12.72 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 4.8 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26160 55 147 Lysozyme C Gallus gallus 3.7 6.49 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 1.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26161 55 147 Lysozyme C Gallus gallus 3.9 9.6 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26162 55 147 Lysozyme C Gallus gallus 2.5 4.74 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 1.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26163 55 147 Lysozyme C Gallus gallus 2.5 4.72 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 1.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26164 55 147 Lysozyme C Gallus gallus 2.8 6.92 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26165 55 147 Lysozyme C Gallus gallus 4.3 12.18 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 4.8 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26166 55 147 Lysozyme C Gallus gallus 4.7 13.92 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 6.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26167 55 147 Lysozyme C Gallus gallus 2.8 5.46 1.95 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 1.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26168 55 147 Lysozyme C Gallus gallus 3.1 7.77 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26169 55 147 Lysozyme C Gallus gallus 4.5 12.3 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 4.8 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26170 55 147 Lysozyme C Gallus gallus 5.1 13.66 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 6.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26171 55 147 Lysozyme C Gallus gallus 3.5 9.25 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26172 55 147 Lysozyme C Gallus gallus 4.8 12.42 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 4.8 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26173 55 147 Lysozyme C Gallus gallus 3.5 6.29 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 1.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26174 55 147 Lysozyme C Gallus gallus 3.7 9.09 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26175 55 147 Lysozyme C Gallus gallus 2.2 4.29 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 1.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26176 55 147 Lysozyme C Gallus gallus 2.9 6.89 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26177 55 147 Lysozyme C Gallus gallus 4.1 12.14 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 4.8 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26178 55 147 Lysozyme C Gallus gallus 2.5 4.6 1.84 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 1.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26179 55 147 Lysozyme C Gallus gallus 2.5 4.65 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 1.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26180 55 147 Lysozyme C Gallus gallus 3.0 7.29 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26181 55 147 Lysozyme C Gallus gallus 4.4 12.29 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 4.8 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26182 55 147 Lysozyme C Gallus gallus 4.6 13.74 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 6.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26183 55 147 Lysozyme C Gallus gallus 2.8 4.92 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 1.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26184 55 147 Lysozyme C Gallus gallus 3.3 7.89 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26185 55 147 Lysozyme C Gallus gallus 4.6 12.39 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 4.8 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26186 55 147 Lysozyme C Gallus gallus 4.8 13.67 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 6.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26187 55 147 Lysozyme C Gallus gallus 3.0 5.43 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 1.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26188 55 147 Lysozyme C Gallus gallus 3.4 8.62 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26189 55 147 Lysozyme C Gallus gallus 2.2 4.2 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 1.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26190 55 147 Lysozyme C Gallus gallus 2.7 6.79 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26191 55 147 Lysozyme C Gallus gallus 4.0 12.19 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 4.8 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26192 55 147 Lysozyme C Gallus gallus 4.5 13.59 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 6.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26193 55 147 Lysozyme C Gallus gallus 2.4 4.73 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 1.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26194 55 147 Lysozyme C Gallus gallus 2.4 4.74 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 1.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26195 55 147 Lysozyme C Gallus gallus 2.9 7.19 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26196 55 147 Lysozyme C Gallus gallus 4.3 12.34 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 4.8 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26197 55 147 Lysozyme C Gallus gallus 4.9 13.69 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 6.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26198 55 147 Lysozyme C Gallus gallus 2.9 5.0 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 1.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26199 55 147 Lysozyme C Gallus gallus 3.4 8.01 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26200 55 147 Lysozyme C Gallus gallus 4.5 12.44 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 4.8 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26201 55 147 Lysozyme C Gallus gallus 5.0 13.71 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 6.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26202 55 147 Lysozyme C Gallus gallus 3.2 5.54 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 1.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26203 55 147 Lysozyme C Gallus gallus 3.5 8.49 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26204 55 147 Lysozyme C Gallus gallus 2.1 4.24 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 1.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26205 55 147 Lysozyme C Gallus gallus 2.8 6.89 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26206 55 147 Lysozyme C Gallus gallus 4.1 12.13 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 4.8 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26207 55 147 Lysozyme C Gallus gallus 4.5 13.49 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 6.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26208 55 147 Lysozyme C Gallus gallus 2.4 4.7 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 1.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26209 55 147 Lysozyme C Gallus gallus 2.9 7.29 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26210 55 147 Lysozyme C Gallus gallus 4.4 12.27 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 4.8 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26211 55 147 Lysozyme C Gallus gallus 5.8 13.64 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 6.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26212 55 147 Lysozyme C Gallus gallus 2.8 4.93 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 1.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26213 55 147 Lysozyme C Gallus gallus 3.2 8.09 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26214 55 147 Lysozyme C Gallus gallus 4.6 12.37 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 4.8 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26215 55 147 Lysozyme C Gallus gallus 4.9 13.67 Yes Cacodylic acid 0.05 M 25.0 CD GdnHCl 6.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26216 55 147 Lysozyme C Gallus gallus 3.1 5.48 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 1.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26217 55 147 Lysozyme C Gallus gallus 3.4 8.69 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 2.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26302 55 147 Lysozyme C Gallus gallus 2.0 3.5 1.78 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 1.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26303 55 147 Lysozyme C Gallus gallus 0.8 1.2 1.57 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 1.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26304 55 147 Lysozyme C Gallus gallus 1.9 3.1 1.65 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 1.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26305 55 147 Lysozyme C Gallus gallus 0.8 1.31 1.6 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 1.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26306 55 147 Lysozyme C Gallus gallus 1.7 3.25 1.95 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 1.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26307 55 147 Lysozyme C Gallus gallus 0.4 0.69 1.61 Yes Glycine hydrochloride 0.05 M 25.0 CD GdnHCl 1.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26320 55 147 Lysozyme C Gallus gallus 4.8 5.66 1.19 Yes Glycine hydrochloride 0.05 M 25.0 CD Urea 1.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26321 55 147 Lysozyme C Gallus gallus 4.4 5.49 1.24 Yes Glycine hydrochloride 0.05 M 25.0 CD Urea 1.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26322 55 147 Lysozyme C Gallus gallus 4.2 4.76 1.13 Yes Glycine hydrochloride 0.05 M 25.0 CD Urea 1.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16226834 10.1016/j.bpc.2005.09.016 2006 ProTherm 26336 55 147 Lysozyme C Gallus gallus 4.51 14.2 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26337 55 147 Lysozyme C Gallus gallus 4.62 13.92 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26338 55 147 Lysozyme C Gallus gallus 4.92 14.12 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26339 55 147 Lysozyme C Gallus gallus 4.85 13.98 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26340 55 147 Lysozyme C Gallus gallus 5.4 14.09 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26341 55 147 Lysozyme C Gallus gallus 4.8 13.99 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26342 55 147 Lysozyme C Gallus gallus 4.72 14.14 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26343 55 147 Lysozyme C Gallus gallus 5.2 14.39 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26344 55 147 Lysozyme C Gallus gallus 4.7 14.18 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26345 55 147 Lysozyme C Gallus gallus 5.05 14.29 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26346 55 147 Lysozyme C Gallus gallus 4.98 14.35 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26347 55 147 Lysozyme C Gallus gallus 5.23 14.24 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26348 55 147 Lysozyme C Gallus gallus 4.75 14.26 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26349 55 147 Lysozyme C Gallus gallus 4.95 14.27 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26350 55 147 Lysozyme C Gallus gallus 4.92 13.94 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26351 55 147 Lysozyme C Gallus gallus 5.15 14.4 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26352 55 147 Lysozyme C Gallus gallus 4.75 14.31 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26353 55 147 Lysozyme C Gallus gallus 4.85 14.26 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26354 55 147 Lysozyme C Gallus gallus 4.9 13.75 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26355 55 147 Lysozyme C Gallus gallus 5.1 14.13 Yes Cacodylic acid 0.05 M 25.0 KCl 0.1 M CD GdnHCl 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 15990095 10.1016/j.febslet.2005.06.005 2005 ProTherm 26492 55 147 Lysozyme C Gallus gallus 4.15 Yes KCl-HCl 0.1 M 25.0 CD GdnHCl 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 18201812 10.1016/j.bpc.2007.12.006 2008 ProTherm 26495 55 147 Lysozyme C Gallus gallus 4.19 Yes KCl-HCl 0.1 M 25.0 CD Urea 2.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 18201812 10.1016/j.bpc.2007.12.006 2008 ProTherm 26965 55 147 Lysozyme C Gallus gallus 9.7 yes Acetic acid/sodium acetate 20.0 Absorbance GdnHCl 4.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 11455591 10.1002/prot.1083 2001 ProTherm 26966 55 147 Lysozyme C Gallus gallus 9.68 yes Acetic acid/sodium acetate 20.0 Absorbance GdnHCl 4.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 11455591 10.1002/prot.1083 2001 ProTherm 26967 55 147 Lysozyme C Gallus gallus 2.51 yes Acetic acid/sodium acetate 20.0 Absorbance GdnHCl 4.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 11455591 10.1002/prot.1083 2001 ProTherm 27116 55 147 Lysozyme C Gallus gallus 4.0 10.56 2.58 Yes HEPES/NaOH 50 mM 20.0 Fluorescence GdnHCl 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 15741330 10.1110/ps.041085005 2005 ProTherm 27117 55 147 Lysozyme C Gallus gallus 4.4 10.33 2.34 Yes HEPES/NaOH 50 mM 20.0 Fluorescence GdnHCl 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 15741330 10.1110/ps.041085005 2005 ProTherm 27118 55 147 Lysozyme C Gallus gallus 4.0 12.91 3.11 Yes HEPES/NaOH 50 mM 20.0 Fluorescence GdnHCl 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 15741330 10.1110/ps.041085005 2005 ProTherm 27130 55 147 Lysozyme C Gallus gallus 5.71 2.4 Unknown None 20.0 HCl 10 mM CD GdnHCl 2.2 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16411236 10.1002/prot.20782 2006 ProTherm 27131 55 147 Lysozyme C Gallus gallus 4.37 1.74 Unknown 3.0 None 20.0 HCl 10 mM CD GdnHCl 2.2 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16411236 10.1002/prot.20782 2006 ProTherm 27132 55 147 Lysozyme C Gallus gallus 8.41 3.68 Unknown 3.0 None 20.0 HCl 10 mM CD GdnHCl 2.2 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16411236 10.1002/prot.20782 2006 ProTherm 27133 55 147 Lysozyme C Gallus gallus 4.02 2.51 Unknown 3.0 None 20.0 HCl 10 mM CD GdnHCl 2.2 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16411236 10.1002/prot.20782 2006 ProTherm 27134 55 147 Lysozyme C Gallus gallus 8.22 4.71 Unknown 3.0 None 20.0 HCl 10 mM CD GdnHCl 2.2 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 16411236 10.1002/prot.20782 2006 ProTherm 999 584 147 F21Y Lysozyme C Gallus gallus -1.2 yes 72.8 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 4LYZ 6.459090969779274 in pocket 8535242 10.1002/pro.5560041011 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6571 584 147 F21Y Lysozyme C Gallus gallus 2.25 0.45 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 4LYZ 6.459090969779274 in pocket 8535242 10.1002/pro.5560041011 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14810 6952 147 C24S, C145A Lysozyme C Gallus gallus Unknown 28.1 Sodium acetate 0.1 M DSC Thermal 3.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0, 9.0 4LYZ 5.84333336353302, 6.236666639645894 10653703 10.1006/jmbi.1999.3442 2000 ProTherm 14814 6952 147 C24S, C145A Lysozyme C Gallus gallus Unknown 36.4 Sodium acetate 0.1 M DSC Thermal 3.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0, 9.0 4LYZ 5.84333336353302, 6.236666639645894 10653703 10.1006/jmbi.1999.3442 2000 ProTherm 236 124 147 M30L Lysozyme C Gallus gallus -1.8 Unknown 64.2 glycine hydrochloride 0.05 M DSC Thermal 2.7 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 4LYZ 7.431249976158142 in pocket 11266617 10.1110/ps.37401 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6754 124 147 M30L Lysozyme C Gallus gallus 0.57 Unknown glycine hydrochloride 0.05 M 66.0 DSC Thermal 2.7 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 4LYZ 7.431249976158142 in pocket 11266617 10.1110/ps.37401 2001 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 237 125 147 M30F Lysozyme C Gallus gallus 0.8 Unknown 66.8 glycine hydrochloride 0.05 M DSC Thermal 2.7 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 4LYZ 7.431249976158142 in pocket 11266617 10.1110/ps.37401 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6755 125 147 M30F Lysozyme C Gallus gallus -0.28 Unknown glycine hydrochloride 0.05 M 66.0 DSC Thermal 2.7 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 4LYZ 7.431249976158142 in pocket 11266617 10.1110/ps.37401 2001 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 15651 7294 147 M30L, L74F Lysozyme C Gallus gallus 3.5 Unknown 69.5 glycine hydrochloride 0.05 M DSC Thermal 2.7 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0, 9.0 4LYZ 7.431249976158142, 7.168749988079071 in pocket 11266617 10.1110/ps.37401 2001 ProTherm 16738 7294 147 M30L, L74F Lysozyme C Gallus gallus -1.12 Unknown glycine hydrochloride 0.05 M 66.0 DSC Thermal 2.7 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0, 9.0 4LYZ 7.431249976158142, 7.168749988079071 in pocket 11266617 10.1110/ps.37401 2001 ProTherm 15652 7295 147 M30F, L74F Lysozyme C Gallus gallus 4.4 Unknown 70.4 glycine hydrochloride 0.05 M DSC Thermal 2.7 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0, 9.0 4LYZ 7.431249976158142, 7.168749988079071 in pocket 11266617 10.1110/ps.37401 2001 ProTherm 16739 7295 147 M30F, L74F Lysozyme C Gallus gallus -1.49 Unknown glycine hydrochloride 0.05 M 66.0 DSC Thermal 2.7 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0, 9.0 4LYZ 7.431249976158142, 7.168749988079071 in pocket 11266617 10.1110/ps.37401 2001 ProTherm 12715 5873 147 K31D Lysozyme C Gallus gallus 6.69 5.98 Unknown sodium carbonate 50 mM 20.0 CD Thermal 9.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 4LYZ 6.444444391462538 7664875 10.1016/0014-5793(95)00846-2 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1000 585 147 H33L Lysozyme C Gallus gallus 2.0 yes 76.0 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 4LYZ 5.296000003814697 in pocket 8535242 10.1002/pro.5560041011 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6572 585 147 H33L Lysozyme C Gallus gallus 2.25 -0.76 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 4LYZ 5.296000003814697 in pocket 8535242 10.1002/pro.5560041011 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14803 6945 147 H33A, T107A, N111A, I116A, S118A Lysozyme C Gallus gallus yes 64.5 Potassium phosphate 66 mM CD Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0, 4.0, 1.0, 8.0, 3.0 4LYZ 5.296000003814697, 6.284285681588309, 6.173750102519989, 6.627499938011169, 5.761666536331177 in pocket 10813830 2000 ProTherm 1001 586 147 N37K Lysozyme C Gallus gallus -2.8 yes 71.2 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 4LYZ 4.400000035762787 8535242 10.1002/pro.5560041011 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6573 586 147 N37K Lysozyme C Gallus gallus 2.25 1.06 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 4LYZ 4.400000035762787 8535242 10.1002/pro.5560041011 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1002 587 147 R39Q Lysozyme C Gallus gallus -0.4 yes 73.6 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 2.0 4LYZ 5.303636355833574 8535242 10.1002/pro.5560041011 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6574 587 147 R39Q Lysozyme C Gallus gallus 2.25 0.15 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 2.0 4LYZ 5.303636355833574 8535242 10.1002/pro.5560041011 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14811 6953 147 C48A, C133A Lysozyme C Gallus gallus Unknown 38.5 Sodium acetate 0.1 M DSC Thermal 3.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0, 9.0 4LYZ 8.288333257039389, 8.621666510899862 10653703 10.1006/jmbi.1999.3442 2000 ProTherm 14815 6953 147 C48A, C133A Lysozyme C Gallus gallus Unknown 47.9 Sodium acetate 0.1 M DSC Thermal 3.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0, 9.0 4LYZ 8.288333257039389, 8.621666510899862 10653703 10.1006/jmbi.1999.3442 2000 ProTherm 1012 597 147 A49V Lysozyme C Gallus gallus 3.1 yes 77.1 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 4LYZ 7.3059999465942385 in pocket 8535242 10.1002/pro.5560041011 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6584 597 147 A49V Lysozyme C Gallus gallus 2.25 -1.2 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 4LYZ 7.3059999465942385 in pocket 8535242 10.1002/pro.5560041011 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1013 598 147 A49I Lysozyme C Gallus gallus 3.6 yes 77.6 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 4LYZ 7.3059999465942385 in pocket 8535242 10.1002/pro.5560041011 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6585 598 147 A49I Lysozyme C Gallus gallus 2.25 -1.4 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 4LYZ 7.3059999465942385 in pocket 8535242 10.1002/pro.5560041011 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1014 599 147 A49L Lysozyme C Gallus gallus 4.7 yes 78.7 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 4LYZ 7.3059999465942385 in pocket 8535242 10.1002/pro.5560041011 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6586 599 147 A49L Lysozyme C Gallus gallus 2.25 -1.8 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 4LYZ 7.3059999465942385 in pocket 8535242 10.1002/pro.5560041011 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1003 588 147 F52Y Lysozyme C Gallus gallus 0.5 yes 74.5 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 4LYZ 5.934545397758484 8535242 10.1002/pro.5560041011 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6575 588 147 F52Y Lysozyme C Gallus gallus 2.25 -0.19 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 4LYZ 5.934545397758484 8535242 10.1002/pro.5560041011 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8362 3644 147 E53Q Lysozyme C Gallus gallus 2.02 0.53 6.49 3.21 Unknown Sodium acetate 0.1 M 35.0 CD GdnHCl 3.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf active site 8.0 4LYZ 5.920000102784899 in pocket 1390669 10.1021/bi00152a018 1992 ProTherm 8365 3644 147 E53Q Lysozyme C Gallus gallus 2.48 0.47 7.97 3.21 Unknown Sodium acetate 0.1 M 35.0 CD GdnHCl 4.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf active site 8.0 4LYZ 5.920000102784899 in pocket 1390669 10.1021/bi00152a018 1992 ProTherm 8368 3644 147 E53Q Lysozyme C Gallus gallus 2.84 0.43 9.13 3.21 Unknown Sodium acetate 0.1 M 35.0 CD GdnHCl 4.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf active site 8.0 4LYZ 5.920000102784899 in pocket 1390669 10.1021/bi00152a018 1992 ProTherm 8371 3644 147 E53Q Lysozyme C Gallus gallus 2.97 -0.15 9.55 3.21 Unknown Sodium acetate 0.1 M 35.0 CD GdnHCl 5.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf active site 8.0 4LYZ 5.920000102784899 in pocket 1390669 10.1021/bi00152a018 1992 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 8374 3644 147 E53Q Lysozyme C Gallus gallus 3.06 -0.48 9.83 3.21 Unknown Sodium acetate 0.1 M 35.0 CD GdnHCl 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf active site 8.0 4LYZ 5.920000102784899 in pocket 1390669 10.1021/bi00152a018 1992 ProTherm 8363 3645 147 E53A Lysozyme C Gallus gallus 3.03 -1.46 8.48 2.8 Unknown Sodium acetate 0.1 M 35.0 CD GdnHCl 3.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf active site 8.0 4LYZ 5.920000102784899 in pocket 1390669 10.1021/bi00152a018 1992 ProTherm 8366 3645 147 E53A Lysozyme C Gallus gallus 3.42 -1.14 9.58 2.8 Unknown Sodium acetate 0.1 M 35.0 CD GdnHCl 4.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf active site 8.0 4LYZ 5.920000102784899 in pocket 1390669 10.1021/bi00152a018 1992 ProTherm SAAFEC_S983.csv 8369 3645 147 E53A Lysozyme C Gallus gallus 3.72 -0.86 10.42 2.8 Unknown Sodium acetate 0.1 M 35.0 CD GdnHCl 4.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf active site 8.0 4LYZ 5.920000102784899 in pocket 1390669 10.1021/bi00152a018 1992 ProTherm 8372 3645 147 E53A Lysozyme C Gallus gallus 3.91 -1.55 10.95 2.8 Unknown Sodium acetate 0.1 M 35.0 CD GdnHCl 5.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf active site 8.0 4LYZ 5.920000102784899 in pocket 1390669 10.1021/bi00152a018 1992 ProTherm 8375 3645 147 E53A Lysozyme C Gallus gallus 3.97 -1.77 11.12 2.8 Unknown Sodium acetate 0.1 M 35.0 CD GdnHCl 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf active site 8.0 4LYZ 5.920000102784899 in pocket 1390669 10.1021/bi00152a018 1992 ProTherm 8364 3646 147 E53H Lysozyme C Gallus gallus 1.11 3.43 3.59 3.24 Unknown Sodium acetate 0.1 M 35.0 CD GdnHCl 3.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf active site 8.0 4LYZ 5.920000102784899 in pocket 1390669 10.1021/bi00152a018 1992 ProTherm 8367 3646 147 E53H Lysozyme C Gallus gallus 1.64 3.13 5.31 3.24 Unknown Sodium acetate 0.1 M 35.0 CD GdnHCl 4.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf active site 8.0 4LYZ 5.920000102784899 in pocket 1390669 10.1021/bi00152a018 1992 ProTherm 8370 3646 147 E53H Lysozyme C Gallus gallus 2.1 2.76 6.8 3.24 Unknown Sodium acetate 0.1 M 35.0 CD GdnHCl 4.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf active site 8.0 4LYZ 5.920000102784899 in pocket 1390669 10.1021/bi00152a018 1992 ProTherm 8373 3646 147 E53H Lysozyme C Gallus gallus 2.42 1.56 7.84 3.24 Unknown Sodium acetate 0.1 M 35.0 CD GdnHCl 5.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf active site 8.0 4LYZ 5.920000102784899 in pocket 1390669 10.1021/bi00152a018 1992 ProTherm 8376 3646 147 E53H Lysozyme C Gallus gallus 2.7 0.61 8.74 3.24 Unknown Sodium acetate 0.1 M 35.0 CD GdnHCl 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf active site 8.0 4LYZ 5.920000102784899 in pocket 1390669 10.1021/bi00152a018 1992 ProTherm 1026 611 147 T58S Lysozyme C Gallus gallus -0.7 yes 73.3 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 4LYZ 5.998571498053415 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6598 611 147 T58S Lysozyme C Gallus gallus 0.27 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 4LYZ 5.998571498053415 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1029 614 147 T58I Lysozyme C Gallus gallus -5.8 yes 68.2 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 4LYZ 5.998571498053415 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6601 614 147 T58I Lysozyme C Gallus gallus 2.2 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 4LYZ 5.998571498053415 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14583 6786 147 T58S, S109T Lysozyme C Gallus gallus 1.6 yes 75.6 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0, 7.0 4LYZ 5.998571498053415, 6.329999844233195 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm 14872 6786 147 T58S, S109T Lysozyme C Gallus gallus -0.61 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0, 7.0 4LYZ 5.998571498053415, 6.329999844233195 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm 14585 6788 147 T58S, I73V, S109T Lysozyme C Gallus gallus -0.8 yes 73.2 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0, 8.0, 7.0 4LYZ 5.998571498053415, 6.290000110864639, 6.329999844233195 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm 14874 6788 147 T58S, I73V, S109T Lysozyme C Gallus gallus 0.3 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0, 8.0, 7.0 4LYZ 5.998571498053415, 6.290000110864639, 6.329999844233195 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm 14586 6789 147 T58S, S109V Lysozyme C Gallus gallus -1.4 yes 72.6 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0, 7.0 4LYZ 5.998571498053415, 6.329999844233195 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm 14875 6789 147 T58S, S109V Lysozyme C Gallus gallus 0.53 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0, 7.0 4LYZ 5.998571498053415, 6.329999844233195 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm 14587 6790 147 T58S, S109A Lysozyme C Gallus gallus -2.3 yes 71.7 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0, 7.0 4LYZ 5.998571498053415, 6.329999844233195 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm 14876 6790 147 T58S, S109A Lysozyme C Gallus gallus 0.87 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0, 7.0 4LYZ 5.998571498053415, 6.329999844233195 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm 14590 6793 147 T58S, I73V Lysozyme C Gallus gallus -3.5 yes 70.5 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0, 8.0 4LYZ 5.998571498053415, 6.290000110864639 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm 14879 6793 147 T58S, I73V Lysozyme C Gallus gallus 1.33 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0, 8.0 4LYZ 5.998571498053415, 6.290000110864639 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm 14591 6794 147 T58S, I73V, S109A Lysozyme C Gallus gallus -4.4 yes 69.6 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0, 8.0, 7.0 4LYZ 5.998571498053415, 6.290000110864639, 6.329999844233195 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm 14880 6794 147 T58S, I73V, S109A Lysozyme C Gallus gallus 1.67 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0, 8.0, 7.0 4LYZ 5.998571498053415, 6.290000110864639, 6.329999844233195 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm 8357 3643 147 N64D Lysozyme C Gallus gallus 2.88 -0.46 7.8 2.71 Unknown Sodium acetate 0.1 M 35.0 CD GdnHCl 3.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 4LYZ 3.8812500089406967 1420152 10.1021/bi00157a021 1992 ProTherm 8358 3643 147 N64D Lysozyme C Gallus gallus 3.27 -0.03 8.86 2.71 Unknown Sodium acetate 0.1 M 35.0 CD GdnHCl 4.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 4LYZ 3.8812500089406967 1420152 10.1021/bi00157a021 1992 ProTherm 8359 3643 147 N64D Lysozyme C Gallus gallus 3.43 0.69 9.3 2.71 Unknown Sodium acetate 0.1 M 35.0 CD GdnHCl 4.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 4LYZ 3.8812500089406967 1420152 10.1021/bi00157a021 1992 ProTherm SAAFEC_S983.csv 8360 3643 147 N64D Lysozyme C Gallus gallus 3.35 0.76 9.08 2.71 Unknown Sodium acetate 0.1 M 35.0 CD GdnHCl 5.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 4LYZ 3.8812500089406967 1420152 10.1021/bi00157a021 1992 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 8361 3643 147 N64D Lysozyme C Gallus gallus 3.3 0.84 8.94 2.71 Unknown Sodium acetate 0.1 M 35.0 CD GdnHCl 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 4LYZ 3.8812500089406967 1420152 10.1021/bi00157a021 1992 ProTherm SAAFEC_S1262.csv 64 50 147 G67A Lysozyme C Gallus gallus 1.7 116.16 -5.7 yes 59.9 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 4LYZ 5.162499964237213 11112507 10.1093/protein/13.10.691 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6758 50 147 G67A Lysozyme C Gallus gallus 1.89 yes glycine 0.05 M 65.6 DSC Thermal 2.7 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 4LYZ 5.162499964237213 11112507 10.1093/protein/13.10.691 2000 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8350 50 147 G67A Lysozyme C Gallus gallus 3.01 -1.92 8.48 yes potassium phosphate 0.05 M 35.0 Fluorescence GdnHCl 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 4LYZ 5.162499964237213 8771183 10.1093/protein/8.10.1023 1995 ProTherm SAAFEC_S1262.csv 12716 5874 147 G67N Lysozyme C Gallus gallus 0.96 11.71 Unknown sodium carbonate 50 mM 20.0 CD Thermal 9.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 4LYZ 5.162499964237213 7664875 10.1016/0014-5793(95)00846-2 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1027 612 147 I73L Lysozyme C Gallus gallus -1.2 yes 72.8 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 4LYZ 6.290000110864639 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6599 612 147 I73L Lysozyme C Gallus gallus 0.45 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 4LYZ 6.290000110864639 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1028 613 147 I73V Lysozyme C Gallus gallus -2.4 yes 71.6 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 4LYZ 6.290000110864639 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm khan_protherm_data_mapped.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6600 613 147 I73V Lysozyme C Gallus gallus 0.91 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 4LYZ 6.290000110864639 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1030 615 147 I73M Lysozyme C Gallus gallus -6.0 yes 68.0 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 4LYZ 6.290000110864639 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6602 615 147 I73M Lysozyme C Gallus gallus 2.27 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 4LYZ 6.290000110864639 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1032 617 147 I73F Lysozyme C Gallus gallus -6.5 yes 67.5 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 4LYZ 6.290000110864639 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6604 617 147 I73F Lysozyme C Gallus gallus 2.46 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 4LYZ 6.290000110864639 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1034 619 147 I73A Lysozyme C Gallus gallus -11.6 yes 62.4 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 4LYZ 6.290000110864639 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6606 619 147 I73A Lysozyme C Gallus gallus 4.4 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 4LYZ 6.290000110864639 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, potapov_with_uniprot_mapping.csv 1035 620 147 I73T Lysozyme C Gallus gallus -13.1 yes 60.9 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 4LYZ 6.290000110864639 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm EASE-MM_S1676.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S1396.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6607 620 147 I73T Lysozyme C Gallus gallus 4.96 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 4LYZ 6.290000110864639 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8868 620 147 I73T Lysozyme C Gallus gallus 2.57 3.3 6.9 2.6 yes Sodium acetate 0.1 M 25.0 CD GdnHCl 5.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 4LYZ 6.290000110864639 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm SAAFEC_S1262.csv 14582 6785 147 I73L, S109T Lysozyme C Gallus gallus 3.3 yes 77.3 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0, 7.0 4LYZ 6.290000110864639, 6.329999844233195 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm 14871 6785 147 I73L, S109T Lysozyme C Gallus gallus -1.25 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0, 7.0 4LYZ 6.290000110864639, 6.329999844233195 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm 14584 6787 147 I73V, S109T Lysozyme C Gallus gallus 0.0 yes 74.0 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0, 7.0 4LYZ 6.290000110864639, 6.329999844233195 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm 14873 6787 147 I73V, S109T Lysozyme C Gallus gallus 0.0 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0, 7.0 4LYZ 6.290000110864639, 6.329999844233195 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm 14588 6791 147 I73V, S109A Lysozyme C Gallus gallus -3.3 yes 70.7 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0, 7.0 4LYZ 6.290000110864639, 6.329999844233195 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm 14877 6791 147 I73V, S109A Lysozyme C Gallus gallus 1.25 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0, 7.0 4LYZ 6.290000110864639, 6.329999844233195 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm 14589 6792 147 I73V, S109V Lysozyme C Gallus gallus -3.3 yes 70.7 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0, 7.0 4LYZ 6.290000110864639, 6.329999844233195 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm 14878 6792 147 I73V, S109V Lysozyme C Gallus gallus 1.25 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0, 7.0 4LYZ 6.290000110864639, 6.329999844233195 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm 14592 6795 147 I73A, S109T Lysozyme C Gallus gallus -7.3 yes 66.7 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0, 7.0 4LYZ 6.290000110864639, 6.329999844233195 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm 14881 6795 147 I73A, S109T Lysozyme C Gallus gallus 2.77 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0, 7.0 4LYZ 6.290000110864639, 6.329999844233195 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm 8352 3638 147 I76M Lysozyme C Gallus gallus 2.98 1.18 Unknown sodium acetate 0.1 M 35.0 HCl Fluorescence GdnHCl 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 4LYZ 6.002499938011169 in pocket 11477222 10.1093/protein/14.6.421 2001 ProTherm SAAFEC_S1262.csv 14812 6954 147 C82A, C98A Lysozyme C Gallus gallus Unknown 37.5 Sodium acetate 0.1 M DSC Thermal 3.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0, 9.0 4LYZ 6.4083333015441895, 8.671666542689005 in pocket 10653703 10.1006/jmbi.1999.3442 2000 ProTherm 14816 6954 147 C82A, C98A Lysozyme C Gallus gallus Unknown 47.2 Sodium acetate 0.1 M DSC Thermal 3.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0, 9.0 4LYZ 6.4083333015441895, 8.671666542689005 in pocket 10653703 10.1006/jmbi.1999.3442 2000 ProTherm 65 51 147 G85A Lysozyme C Gallus gallus 1.74 115.92 -2.9 yes 62.7 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 4LYZ 6.057499885559082 11112507 10.1093/protein/13.10.691 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6759 51 147 G85A Lysozyme C Gallus gallus 0.98 yes glycine 0.05 M 65.6 DSC Thermal 2.7 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 4LYZ 6.057499885559082 11112507 10.1093/protein/13.10.691 2000 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8351 51 147 G85A Lysozyme C Gallus gallus 3.24 -1.27 9.13 yes potassium phosphate 0.05 M 35.0 Fluorescence GdnHCl 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 4LYZ 6.057499885559082 8771183 10.1093/protein/8.10.1023 1995 ProTherm SAAFEC_S1262.csv 1004 589 147 R86K Lysozyme C Gallus gallus -0.1 yes 73.9 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 4LYZ 6.1499999869953506 8535242 10.1002/pro.5560041011 1995 ProTherm AUTOMUTE_S1749.csv, AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, HotMuSiC_S1626.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, Saraboji_S1791.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 6576 589 147 R86K Lysozyme C Gallus gallus 2.25 0.04 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 4LYZ 6.1499999869953506 8535242 10.1002/pro.5560041011 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 12717 5875 147 P88N Lysozyme C Gallus gallus 2.15 10.52 Unknown sodium carbonate 50 mM 20.0 CD Thermal 9.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1.0 4LYZ 4.788571425846645 7664875 10.1016/0014-5793(95)00846-2 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 15132 6994 147 P88G, G89P Lysozyme C Gallus gallus 3.25 1.0 8.8 2.7 yes acetate 0.1 M 35.0 Fluorescence GdnHCl 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1.0, 1.0 4LYZ 4.788571425846645, 4.027499854564667 8720127 10.1093/oxfordjournals.jbchem.a124999 1995 ProTherm 66 52 147 G89A Lysozyme C Gallus gallus 2.29 111.85 -1.2 yes 64.4 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1.0 4LYZ 4.027499854564667 11112507 10.1093/protein/13.10.691 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6760 52 147 G89A Lysozyme C Gallus gallus 0.38 yes glycine 0.05 M 65.6 DSC Thermal 2.7 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1.0 4LYZ 4.027499854564667 11112507 10.1093/protein/13.10.691 2000 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1005 590 147 R91K Lysozyme C Gallus gallus 0.6 yes 74.6 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 4LYZ 3.116363671692935 8535242 10.1002/pro.5560041011 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6577 590 147 R91K Lysozyme C Gallus gallus 2.25 -0.23 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 4LYZ 3.116363671692935 8535242 10.1002/pro.5560041011 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14813 6955 147 C94A, C112A Lysozyme C Gallus gallus Unknown 41.5 Sodium acetate 0.1 M DSC Thermal 2.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0, 9.0 4LYZ 8.256666660308838, 8.298333168029785 in pocket 10653703 10.1006/jmbi.1999.3442 2000 ProTherm 14817 6955 147 C94A, C112A Lysozyme C Gallus gallus Unknown 51.3 Sodium acetate 0.1 M DSC Thermal 3.9 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0, 9.0 4LYZ 8.256666660308838, 8.298333168029785 in pocket 10653703 10.1006/jmbi.1999.3442 2000 ProTherm 1006 591 147 N95H Lysozyme C Gallus gallus -1.0 yes 73.0 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 4LYZ 5.086250007152557 8535242 10.1002/pro.5560041011 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6578 591 147 N95H Lysozyme C Gallus gallus 2.25 0.38 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 4LYZ 5.086250007152557 8535242 10.1002/pro.5560041011 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8353 3639 147 I96M Lysozyme C Gallus gallus 3.08 0.9 Unknown sodium acetate 0.1 M 35.0 HCl Fluorescence GdnHCl 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 6.0 4LYZ 5.0612499713897705 in pocket 11477222 10.1093/protein/14.6.421 2001 ProTherm SAAFEC_S1262.csv 14802 6944 147 T107A, N111A, I116A, S118A Lysozyme C Gallus gallus yes 66.0 Potassium phosphate 66 mM CD Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0, 1.0, 8.0, 3.0 4LYZ 6.284285681588309, 6.173750102519989, 6.627499938011169, 5.761666536331177 in pocket 10813830 2000 ProTherm 14805 6947 147 T107A, N111A, S118A Lysozyme C Gallus gallus yes 74.6 Potassium phosphate 66 mM CD Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0, 1.0, 3.0 4LYZ 6.284285681588309, 6.173750102519989, 5.761666536331177 in pocket 10813830 2000 ProTherm 14806 6948 147 T107A, N111A, I116A Lysozyme C Gallus gallus yes 66.9 Potassium phosphate 66 mM CD Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0, 1.0, 8.0 4LYZ 6.284285681588309, 6.173750102519989, 6.627499938011169 in pocket 10813830 2000 ProTherm 1023 608 147 S109T Lysozyme C Gallus gallus 2.6 yes 76.6 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 4LYZ 6.329999844233195 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6595 608 147 S109T Lysozyme C Gallus gallus -0.99 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 4LYZ 6.329999844233195 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1024 609 147 S109V Lysozyme C Gallus gallus -0.2 yes 73.8 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 4LYZ 6.329999844233195 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm HotMuSiC_S1626.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6596 609 147 S109V Lysozyme C Gallus gallus 0.08 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 4LYZ 6.329999844233195 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1025 610 147 S109A Lysozyme C Gallus gallus -0.4 yes 73.6 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 4LYZ 6.329999844233195 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm AUTOMUTE_S1925.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6597 610 147 S109A Lysozyme C Gallus gallus 0.15 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 4LYZ 6.329999844233195 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm AUTOMUTE_S1925.csv, capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1031 616 147 S109D Lysozyme C Gallus gallus -6.1 yes 67.9 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 4LYZ 6.329999844233195 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6603 616 147 S109D Lysozyme C Gallus gallus 2.31 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 4LYZ 6.329999844233195 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1033 618 147 S109Y Lysozyme C Gallus gallus -8.1 yes 65.9 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 4LYZ 6.329999844233195 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6605 618 147 S109Y Lysozyme C Gallus gallus 3.07 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 4LYZ 6.329999844233195 in pocket 8535241 10.1002/pro.5560041010 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14804 6946 147 N111A, I116A, S118A Lysozyme C Gallus gallus yes 65.4 Potassium phosphate 66 mM CD Thermal 7.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 1.0, 8.0, 3.0 4LYZ 6.173750102519989, 6.627499938011169, 5.761666536331177 in pocket 10813830 2000 ProTherm 12718 5876 147 C112A Lysozyme C Gallus gallus 4.78 7.89 Unknown sodium carbonate 50 mM 20.0 CD Thermal 9.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 4LYZ 8.298333168029785 in pocket 7664875 10.1016/0014-5793(95)00846-2 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8354 3640 147 I116M Lysozyme C Gallus gallus 3.08 0.9 Unknown sodium acetate 0.1 M 35.0 HCl Fluorescence GdnHCl 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 8.0 4LYZ 6.627499938011169 11477222 10.1093/protein/14.6.421 2001 ProTherm SAAFEC_S1262.csv 1007 592 147 D119G Lysozyme C Gallus gallus 1.2 yes 75.2 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf binding site 4.0 4LYZ 3.1012499928474426 8535242 10.1002/pro.5560041011 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6579 592 147 D119G Lysozyme C Gallus gallus 2.25 -0.45 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf binding site 4.0 4LYZ 3.1012499928474426 8535242 10.1002/pro.5560041011 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1015 600 147 D119S Lysozyme C Gallus gallus 2.3 yes 76.3 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf binding site 4.0 4LYZ 3.1012499928474426 8535242 10.1002/pro.5560041011 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6587 600 147 D119S Lysozyme C Gallus gallus 2.25 -0.87 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf binding site 4.0 4LYZ 3.1012499928474426 8535242 10.1002/pro.5560041011 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1016 601 147 D119A Lysozyme C Gallus gallus 2.0 yes 76.0 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf binding site 4.0 4LYZ 3.1012499928474426 8535242 10.1002/pro.5560041011 1995 ProTherm AUTOMUTE_S1749.csv, HotMuSiC_S1626.csv, Saraboji_S1791.csv 6588 601 147 D119A Lysozyme C Gallus gallus 2.25 -0.76 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf binding site 4.0 4LYZ 3.1012499928474426 8535242 10.1002/pro.5560041011 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1017 602 147 D119F Lysozyme C Gallus gallus 1.9 yes 75.9 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf binding site 4.0 4LYZ 3.1012499928474426 8535242 10.1002/pro.5560041011 1995 ProTherm HotMuSiC_S1626.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6589 602 147 D119F Lysozyme C Gallus gallus 2.25 -0.72 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf binding site 4.0 4LYZ 3.1012499928474426 8535242 10.1002/pro.5560041011 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1018 603 147 D119R Lysozyme C Gallus gallus 0.7 yes 74.7 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf binding site 4.0 4LYZ 3.1012499928474426 8535242 10.1002/pro.5560041011 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6590 603 147 D119R Lysozyme C Gallus gallus 2.25 -0.27 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf binding site 4.0 4LYZ 3.1012499928474426 8535242 10.1002/pro.5560041011 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1019 604 147 D119K Lysozyme C Gallus gallus 0.5 yes 74.5 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf binding site 4.0 4LYZ 3.1012499928474426 8535242 10.1002/pro.5560041011 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6591 604 147 D119K Lysozyme C Gallus gallus 2.25 -0.19 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf binding site 4.0 4LYZ 3.1012499928474426 8535242 10.1002/pro.5560041011 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1020 605 147 D119N Lysozyme C Gallus gallus 0.1 yes 74.1 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf binding site 4.0 4LYZ 3.1012499928474426 8535242 10.1002/pro.5560041011 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6592 605 147 D119N Lysozyme C Gallus gallus 2.25 -0.04 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf binding site 4.0 4LYZ 3.1012499928474426 8535242 10.1002/pro.5560041011 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1021 606 147 D119E Lysozyme C Gallus gallus 0.0 yes 74.0 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf binding site 4.0 4LYZ 3.1012499928474426 8535242 10.1002/pro.5560041011 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6593 606 147 D119E Lysozyme C Gallus gallus 2.25 0.0 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf binding site 4.0 4LYZ 3.1012499928474426 8535242 10.1002/pro.5560041011 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1022 607 147 D119Q Lysozyme C Gallus gallus -0.2 yes 73.8 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf binding site 4.0 4LYZ 3.1012499928474426 8535242 10.1002/pro.5560041011 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6594 607 147 D119Q Lysozyme C Gallus gallus 2.25 0.08 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf binding site 4.0 4LYZ 3.1012499928474426 8535242 10.1002/pro.5560041011 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8355 3641 147 D119P Lysozyme C Gallus gallus 2.7 2.4 7.7 2.7 yes acetate 0.1 M 35.0 CD GdnHCl 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf binding site 4.0 4LYZ 3.1012499928474426 8475043 10.1093/protein/6.2.183 1993 ProTherm SAAFEC_S1262.csv 15131 6993 147 D119G, G120P Lysozyme C Gallus gallus 3.95 -0.9 11.0 2.8 yes acetate 0.1 M 35.0 CD GdnHCl 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf binding site 4.0, 3.0 4LYZ 3.1012499928474426, 5.4049999713897705 8475043 10.1093/protein/6.2.183 1993 ProTherm 67 53 147 G120A Lysozyme C Gallus gallus 2.01 113.29 0.0 yes 65.6 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 4LYZ 5.4049999713897705 11112507 10.1093/protein/13.10.691 2000 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6761 53 147 G120A Lysozyme C Gallus gallus -0.02 yes glycine 0.05 M 65.6 DSC Thermal 2.7 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 4LYZ 5.4049999713897705 11112507 10.1093/protein/13.10.691 2000 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1008 593 147 G120V Lysozyme C Gallus gallus -0.1 yes 73.9 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 4LYZ 5.4049999713897705 8535242 10.1002/pro.5560041011 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6580 593 147 G120V Lysozyme C Gallus gallus 2.25 0.04 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 4LYZ 5.4049999713897705 8535242 10.1002/pro.5560041011 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1009 594 147 G120R Lysozyme C Gallus gallus 1.0 yes 75.0 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 4LYZ 5.4049999713897705 8535242 10.1002/pro.5560041011 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6581 594 147 G120R Lysozyme C Gallus gallus 2.25 -0.38 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 4LYZ 5.4049999713897705 8535242 10.1002/pro.5560041011 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8356 3642 147 G120P Lysozyme C Gallus gallus 3.5 0.1 10.0 2.7 yes acetate 0.1 M 35.0 CD GdnHCl 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 4LYZ 5.4049999713897705 8475043 10.1093/protein/6.2.183 1993 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 15130 6992 147 G120A, G122A Lysozyme C Gallus gallus 2.98 -2.0 8.4 yes potassium phosphate 0.05 M 35.0 Fluorescence GdnHCl 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0, 8.0 4LYZ 5.4049999713897705, 6.289999902248383 8771183 10.1093/protein/8.10.1023 1995 ProTherm 12719 5877 147 N121D Lysozyme C Gallus gallus -0.24 12.91 Unknown sodium carbonate 50 mM 20.0 CD Thermal 9.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 4LYZ 4.957500010728836 7664875 10.1016/0014-5793(95)00846-2 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 12720 5878 147 M123T Lysozyme C Gallus gallus 0.24 12.43 Unknown sodium carbonate 50 mM 20.0 CD Thermal 9.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 7.0 4LYZ 7.536249905824661 in pocket 7664875 10.1016/0014-5793(95)00846-2 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8377 3647 147 W126Y Lysozyme C Gallus gallus 1.76 1.41 5.61 3.19 yes Sodium acetate 0.1 M 35.0 Fluorescence GdnHCl 3.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 4LYZ 6.242857115609305 in pocket 1610799 10.1021/bi00139a017 1992 ProTherm 8379 3647 147 W126Y Lysozyme C Gallus gallus 2.2 1.42 7.02 3.19 yes Sodium acetate 0.1 M 35.0 Fluorescence GdnHCl 4.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 4LYZ 6.242857115609305 in pocket 1610799 10.1021/bi00139a017 1992 ProTherm 8381 3647 147 W126Y Lysozyme C Gallus gallus 2.57 1.36 8.2 3.19 yes Sodium acetate 0.1 M 35.0 Fluorescence GdnHCl 4.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 4LYZ 6.242857115609305 in pocket 1610799 10.1021/bi00139a017 1992 ProTherm 8383 3647 147 W126Y Lysozyme C Gallus gallus 2.55 1.27 8.13 3.19 yes Sodium acetate 0.1 M 35.0 Fluorescence GdnHCl 5.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 4LYZ 6.242857115609305 in pocket 1610799 10.1021/bi00139a017 1992 ProTherm 8385 3647 147 W126Y Lysozyme C Gallus gallus 2.52 1.31 8.04 3.19 yes Sodium acetate 0.1 M 35.0 Fluorescence GdnHCl 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 4LYZ 6.242857115609305 in pocket 1610799 10.1021/bi00139a017 1992 ProTherm 8378 3648 147 W126Q Lysozyme C Gallus gallus 1.18 3.59 3.43 2.91 yes Sodium acetate 0.1 M 35.0 Fluorescence GdnHCl 3.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 4LYZ 6.242857115609305 in pocket 1610799 10.1021/bi00139a017 1992 ProTherm 8380 3648 147 W126Q Lysozyme C Gallus gallus 1.66 3.61 4.83 2.91 yes Sodium acetate 0.1 M 35.0 Fluorescence GdnHCl 4.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 4LYZ 6.242857115609305 in pocket 1610799 10.1021/bi00139a017 1992 ProTherm 8382 3648 147 W126Q Lysozyme C Gallus gallus 1.91 4.0 5.56 2.91 yes Sodium acetate 0.1 M 35.0 Fluorescence GdnHCl 4.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 4LYZ 6.242857115609305 in pocket 1610799 10.1021/bi00139a017 1992 ProTherm 8384 3648 147 W126Q Lysozyme C Gallus gallus 2.01 3.55 5.85 2.91 yes Sodium acetate 0.1 M 35.0 Fluorescence GdnHCl 5.0 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 4LYZ 6.242857115609305 in pocket 1610799 10.1021/bi00139a017 1992 ProTherm 8386 3648 147 W126Q Lysozyme C Gallus gallus 2.03 3.44 5.91 2.91 yes Sodium acetate 0.1 M 35.0 Fluorescence GdnHCl 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 9.0 4LYZ 6.242857115609305 in pocket 1610799 10.1021/bi00139a017 1992 ProTherm 1010 595 147 R132H Lysozyme C Gallus gallus 1.8 yes 75.8 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 4LYZ 6.356363599950617 8535242 10.1002/pro.5560041011 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6582 595 147 R132H Lysozyme C Gallus gallus 2.25 -0.68 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 4.0 4LYZ 6.356363599950617 8535242 10.1002/pro.5560041011 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 68 54 147 G135A Lysozyme C Gallus gallus 1.53 110.9 -4.6 yes 61.0 glycine 0.05 M DSC Thermal 2.7 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 4LYZ 5.25 11112507 10.1093/protein/13.10.691 2000 ProTherm EASE-MM_S543.csv, PoPMuSiC-2.0_S2648.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6762 54 147 G135A Lysozyme C Gallus gallus 1.46 yes glycine 0.05 M 65.6 DSC Thermal 2.7 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 4LYZ 5.25 11112507 10.1093/protein/13.10.691 2000 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 15133 6995 147 G135P, T136G Lysozyme C Gallus gallus 2.58 2.6 7.2 2.8 yes acetate 0.1 M 35.0 Fluorescence GdnHCl 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0, 3.0 4LYZ 5.25, 6.919999923024859 8720127 10.1093/oxfordjournals.jbchem.a124999 1995 ProTherm 8387 3649 147 T136P Lysozyme C Gallus gallus 2.77 2.0 7.8 2.8 yes acetate 0.1 M 35.0 Fluorescence GdnHCl 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 3.0 4LYZ 6.919999923024859 8720127 10.1093/oxfordjournals.jbchem.a124999 1995 ProTherm 1011 596 147 Q139H Lysozyme C Gallus gallus -1.2 yes 72.8 Potassium phosphate 66 mM CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 4LYZ 3.8355555799272327 8535242 10.1002/pro.5560041011 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6583 596 147 Q139H Lysozyme C Gallus gallus 2.25 0.45 yes Potassium phosphate 66 mM 74.0 CD Thermal 6.4 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0 4LYZ 3.8355555799272327 8535242 10.1002/pro.5560041011 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 15134 6996 147 Q139P, A140G Lysozyme C Gallus gallus 2.59 2.8 7.0 2.7 yes acetate 0.1 M 35.0 Fluorescence GdnHCl 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0, 3.0 4LYZ 3.8355555799272327, 5.567999982833863 8720127 10.1093/oxfordjournals.jbchem.a124999 1995 ProTherm 15135 6997 147 Q139G, A140P Lysozyme C Gallus gallus 2.88 1.7 8.1 2.8 yes acetate 0.1 M 35.0 Fluorescence GdnHCl 5.5 3.2.1.17 P00698 IPR001916:Glyco_hydro_22, IPR019799:Glyco_hydro_22_CS, IPR000974:Glyco_hydro_22_lys, IPR023346:Lysozyme-like_dom_sf 5.0, 3.0 4LYZ 3.8355555799272327, 5.567999982833863 8720127 10.1093/oxfordjournals.jbchem.a124999 1995 ProTherm 17475 66 268 Tryptophan synthase alpha chain Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) Unknown 46.0 sodium N,N-bis(2-hydroxyethyl)glycine 0.05 M Enzyme activity Thermal 7.8 4.2.1.20 P00929 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 3126743 10.1016/s0006-291x(88)80333-4 1988 ProTherm 17726 66 268 Tryptophan synthase alpha chain Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 3.03 3.68 Unknown 46.2 sodium tetraborate 1 mM DSC Thermal 9.01 4.2.1.20 P00929 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA DOI: 10.1016/0040-6031(90)80386-D ProTherm 19567 66 268 Tryptophan synthase alpha chain Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) yes(>70%) 47.6 Sodium tetraborate 1 mM DSC Thermal 9.0 4.2.1.20 P00929 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8797836 10.1111/j.1432-1033.1996.0063h.x 1996 ProTherm 20683 66 268 Tryptophan synthase alpha chain Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 13.17 yes Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P00929 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 1540577 10.1021/bi00123a002 1992 ProTherm 20684 66 268 Tryptophan synthase alpha chain Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 2.75 7.35 2.68 yes 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P00929 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 1540577 10.1021/bi00123a002 1992 ProTherm 20685 66 268 Tryptophan synthase alpha chain Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 3.64 5.81 1.6 yes 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P00929 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 1540577 10.1021/bi00123a002 1992 ProTherm 20709 66 268 Tryptophan synthase alpha chain Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 2.75 7.4 2.7 Unknown 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P00929 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8504078 10.1021/bi00072a011 1993 ProTherm 20710 66 268 Tryptophan synthase alpha chain Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 3.63 5.8 1.6 Unknown 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P00929 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8504078 10.1021/bi00072a011 1993 ProTherm 21251 66 268 Tryptophan synthase alpha chain Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 9.7 yes Potassium phosphate 0.01 M 25.0 CD GdnHCl 7.0 4.2.1.20 P00929 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 6367660 10.1016/0003-9861(84)90174-7 1984 ProTherm 10505 4430 268 A18G Tryptophan synthase alpha chain Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 1.88 4.1 3.3 1.7 Unknown 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P00929 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8.0 2WSY 26.655999755859376, 26.655999755859376 in pocket 8504078 10.1021/bi00072a011 1993 ProTherm 10506 4431 268 A18V Tryptophan synthase alpha chain Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 3.77 0.0 5.8 1.5 Unknown 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P00929 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8.0 2WSY 26.655999755859376, 26.655999755859376 in pocket 8504078 10.1021/bi00072a011 1993 ProTherm 10507 4431 268 A18V Tryptophan synthase alpha chain Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 2.24 4.1 3.3 1.5 Unknown 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P00929 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8.0 2WSY 26.655999755859376, 26.655999755859376 in pocket 8504078 10.1021/bi00072a011 1993 ProTherm 10508 4431 268 A18V Tryptophan synthase alpha chain Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 3.78 -0.1 5.9 1.6 Unknown 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P00929 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8.0 2WSY 26.655999755859376, 26.655999755859376 in pocket 8504078 10.1021/bi00072a011 1993 ProTherm potapov_with_uniprot_mapping.csv 15294 7090 268 A18G, I232V Tryptophan synthase alpha chain Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 2.08 5.5 1.9 0.9 Unknown 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P00929 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8.0, 9.0 2WSY 26.655999755859376, 27.332499980926514, 26.655999755859376, 27.332499980926514 in pocket 8504078 10.1021/bi00072a011 1993 ProTherm 15295 7090 268 A18G, I232V Tryptophan synthase alpha chain Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 3.46 0.2 5.6 1.6 Unknown 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P00929 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8.0, 9.0 2WSY 26.655999755859376, 27.332499980926514, 26.655999755859376, 27.332499980926514 in pocket 8504078 10.1021/bi00072a011 1993 ProTherm 15296 7091 268 A18V, I232V Tryptophan synthase alpha chain Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 2.12 3.0 4.4 2.1 Unknown 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P00929 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8.0, 9.0 2WSY 26.655999755859376, 27.332499980926514, 26.655999755859376, 27.332499980926514 in pocket 8504078 10.1021/bi00072a011 1993 ProTherm 15297 7091 268 A18V, I232V Tryptophan synthase alpha chain Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 3.73 -1.0 6.8 1.8 Unknown 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P00929 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8.0, 9.0 2WSY 26.655999755859376, 27.332499980926514, 26.655999755859376, 27.332499980926514 in pocket 8504078 10.1021/bi00072a011 1993 ProTherm 10289 4343 268 F22L Tryptophan synthase alpha chain Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 1.05 12.11 yes Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P00929 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8.0 2WSY 24.617272637107156, 24.617272637107156 in pocket 1540577 10.1021/bi00123a002 1992 ProTherm 10292 4343 268 F22L Tryptophan synthase alpha chain Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 2.1 0.97 6.38 2.96 yes 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P00929 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8.0 2WSY 24.617272637107156, 24.617272637107156 in pocket 1540577 10.1021/bi00123a002 1992 ProTherm 10293 4343 268 F22L Tryptophan synthase alpha chain Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 3.3 0.08 5.73 1.7 yes 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P00929 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8.0 2WSY 24.617272637107156, 24.617272637107156 in pocket 1540577 10.1021/bi00123a002 1992 ProTherm 10290 4344 268 F22I Tryptophan synthase alpha chain Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 4.58 8.58 yes Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P00929 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8.0 2WSY 24.617272637107156, 24.617272637107156 in pocket 1540577 10.1021/bi00123a002 1992 ProTherm 10294 4344 268 F22I Tryptophan synthase alpha chain Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 2.0 4.19 3.16 1.57 yes 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P00929 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8.0 2WSY 24.617272637107156, 24.617272637107156 in pocket 1540577 10.1021/bi00123a002 1992 ProTherm 10295 4344 268 F22I Tryptophan synthase alpha chain Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 3.6 0.38 5.43 1.51 yes 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P00929 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8.0 2WSY 24.617272637107156, 24.617272637107156 in pocket 1540577 10.1021/bi00123a002 1992 ProTherm 10291 4345 268 F22V Tryptophan synthase alpha chain Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 3.44 9.72 yes Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P00929 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8.0 2WSY 24.617272637107156, 24.617272637107156 in pocket 1540577 10.1021/bi00123a002 1992 ProTherm 10296 4345 268 F22V Tryptophan synthase alpha chain Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 1.8 3.5 3.85 2.04 yes 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P00929 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8.0 2WSY 24.617272637107156, 24.617272637107156 in pocket 1540577 10.1021/bi00123a002 1992 ProTherm 10297 4345 268 F22V Tryptophan synthase alpha chain Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 3.3 -0.06 5.87 1.74 yes 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P00929 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 8.0 2WSY 24.617272637107156, 24.617272637107156 in pocket 1540577 10.1021/bi00123a002 1992 ProTherm 79 60 268 C81S Tryptophan synthase alpha chain Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) -5.0 Unknown 41.0 sodium N,N-bis(2-hydroxyethyl)glycine 0.05 M Enzyme activity Thermal 7.8 4.2.1.20 P00929 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 7.0 2WSY 39.56000073750814, 39.56000073750814 in pocket 3126743 10.1016/s0006-291x(88)80333-4 1988 ProTherm Saraboji_S1791.csv 80 61 268 C118S Tryptophan synthase alpha chain Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) -5.0 Unknown 41.0 sodium N,N-bis(2-hydroxyethyl)glycine 0.05 M Enzyme activity Thermal 7.8 4.2.1.20 P00929 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 7.0 2WSY 22.883333206176758, 22.883333206176758 3126743 10.1016/s0006-291x(88)80333-4 1988 ProTherm Saraboji_S1791.csv 10513 4434 268 Y175Q Tryptophan synthase alpha chain Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 2.05 1.4 6.0 2.9 Unknown 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P00929 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 2WSY 16.004166841506958, 16.004166841506958 in pocket 8504078 10.1021/bi00072a011 1993 ProTherm 10514 4434 268 Y175Q Tryptophan synthase alpha chain Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 2.91 -2.1 7.9 2.7 Unknown 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P00929 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 2WSY 16.004166841506958, 16.004166841506958 in pocket 8504078 10.1021/bi00072a011 1993 ProTherm potapov_with_uniprot_mapping.csv 15298 7092 268 Y175Q, L209V Tryptophan synthase alpha chain Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 2.23 3.8 3.6 1.6 Unknown 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P00929 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0, 7.0 2WSY 16.004166841506958, 17.586249947547913, 16.004166841506958, 17.586249947547913 in pocket 8504078 10.1021/bi00072a011 1993 ProTherm 15299 7092 268 Y175Q, L209V Tryptophan synthase alpha chain Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 4.32 -3.9 9.7 2.2 Unknown 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P00929 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0, 7.0 2WSY 16.004166841506958, 17.586249947547913, 16.004166841506958, 17.586249947547913 in pocket 8504078 10.1021/bi00072a011 1993 ProTherm 10511 4433 268 L209V Tryptophan synthase alpha chain Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 2.3 3.4 4.0 1.7 Unknown 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P00929 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 7.0 2WSY 17.586249947547913, 17.586249947547913 in pocket 8504078 10.1021/bi00072a011 1993 ProTherm 10512 4433 268 L209V Tryptophan synthase alpha chain Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 3.44 2.0 3.8 1.1 Unknown 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P00929 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 7.0 2WSY 17.586249947547913, 17.586249947547913 in pocket 8504078 10.1021/bi00072a011 1993 ProTherm 10509 4432 268 I232V Tryptophan synthase alpha chain Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 2.31 3.9 3.5 1.5 Unknown 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P00929 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 2WSY 27.332499980926514, 27.332499980926514 in pocket 8504078 10.1021/bi00072a011 1993 ProTherm 10510 4432 268 I232V Tryptophan synthase alpha chain Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 3.28 1.5 4.3 1.3 Unknown 3.0 Potassium phosphate 10 mM 25.0 CD Urea 7.8 4.2.1.20 P00929 IPR013785:Aldolase_TIM, IPR011060:RibuloseP-bd_barrel, IPR018204:Trp_synthase_alpha_AS, IPR002028:Trp_synthase_suA 9.0 2WSY 27.332499980926514, 27.332499980926514 in pocket 8504078 10.1021/bi00072a011 1993 ProTherm 22084 69 68 Inhibitor of trypsin and hageman factor Cucurbita maxima 0.42 64.0 yes 70.9 dialyzate DSC Thermal 2.5 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 11266603 10.1110/ps.26801 2001 ProTherm 5041726 4889221 67 1S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.88212493353374 0.19125037767673 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 2.319090973247181 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041742 4889221 67 1S Inhibitor of trypsin and hageman factor Cucurbita maxima -1.06232575142351 0.173048732877202 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 2.319090973247181 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041727 4889222 68 S1A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0267042266655911 0.0634396861833577 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 2.319090973247181 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041728 4889223 68 S1C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0717334439118515 0.0498280428907811 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 2.319090973247181 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041729 4889224 68 S1D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0270038192631129 0.157546930197504 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 2.319090973247181 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041730 4889225 68 S1E Inhibitor of trypsin and hageman factor Cucurbita maxima 0.125964742257128 0.143780155518769 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 2.319090973247181 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041731 4889226 68 S1F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0178073161644109 0.0712674649630213 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 2.319090973247181 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041732 4889227 68 S1G Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0396127990056591 0.0422393084149059 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 2.319090973247181 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041733 4889228 68 S1H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.493157395490188 0.120026511083906 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 2.319090973247181 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041734 4889229 68 S1I Inhibitor of trypsin and hageman factor Cucurbita maxima 0.062095738981844 0.15342586757826 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 2.319090973247181 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041735 4889230 68 S1K Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0328076386223113 0.0719568248308866 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 2.319090973247181 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041736 4889231 68 S1L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.285336578234852 0.0519801973539516 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 2.319090973247181 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041737 4889232 68 S1M Inhibitor of trypsin and hageman factor Cucurbita maxima 0.110644134619895 0.0730048861060549 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 2.319090973247181 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041738 4889233 68 S1N Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0296488710250169 0.0791172048697285 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 2.319090973247181 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041739 4889234 68 S1P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.485513915640261 0.0996222759022382 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 2.319090973247181 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041740 4889235 68 S1Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.136198843382022 0.124867765517914 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 2.319090973247181 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041741 4889236 68 S1R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.219968712294489 0.061161163022746 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 2.319090973247181 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043081 4890563 68 S1T Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0325755218350421 0.0605259637385769 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 2.319090973247181 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043082 4890564 68 S1V Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0424575791659111 0.056210183924493 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 2.319090973247181 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043083 4890565 68 S1W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.514202920772497 0.0607831815272601 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 2.319090973247181 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043084 4890566 68 S1Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.112147675607818 0.10908751266124 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 2.319090973247181 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041743 4889237 68 S2A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.112681724154031 0.0442624941127468 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 1.5718182216991077 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041744 4889238 68 S2C Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0358467491160909 0.0637262784414375 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 1.5718182216991077 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041745 4889239 68 S2D Inhibitor of trypsin and hageman factor Cucurbita maxima 0.150809335592156 0.0614817450956438 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 1.5718182216991077 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041746 4889240 68 S2E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.105851102898281 0.0752236526891068 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 1.5718182216991077 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041747 4889241 68 S2F Inhibitor of trypsin and hageman factor Cucurbita maxima 0.214732319515642 0.057548292219226 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 1.5718182216991077 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041748 4889242 68 S2G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.363810135848968 0.0548936229051672 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 1.5718182216991077 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041749 4889243 68 S2H Inhibitor of trypsin and hageman factor Cucurbita maxima 0.212603682621538 0.0700626618790234 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 1.5718182216991077 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041750 4889244 68 S2I Inhibitor of trypsin and hageman factor Cucurbita maxima 0.178406941985492 0.0647018616996198 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 1.5718182216991077 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041751 4889245 68 S2K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0757545523641748 0.075804475466987 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 1.5718182216991077 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041752 4889246 68 S2L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0657815376410852 0.0446014296060332 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 1.5718182216991077 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041753 4889247 68 S2M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.159650735993435 0.0629076349211282 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 1.5718182216991077 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041754 4889248 68 S2N Inhibitor of trypsin and hageman factor Cucurbita maxima 0.292847715528937 0.087215597635604 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 1.5718182216991077 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041755 4889249 68 S2P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0419105752641297 0.0464243650925937 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 1.5718182216991077 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041756 4889250 68 S2Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0152855202159017 0.0767952182905394 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 1.5718182216991077 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041757 4889251 68 S2R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0853938767136283 0.0450444038019546 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 1.5718182216991077 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043077 4890559 68 S2T Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0638923948895047 0.0456150332340992 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 1.5718182216991077 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043078 4890560 68 S2V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0599266166015889 0.0474335513042818 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 1.5718182216991077 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043079 4890561 68 S2W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0919118600485408 0.054474184271862 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 1.5718182216991077 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043080 4890562 68 S2Y Inhibitor of trypsin and hageman factor Cucurbita maxima 0.132654743924311 0.0587384665475612 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 1.5718182216991077 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 15646 7289 68 C3S, C48S Inhibitor of trypsin and hageman factor Cucurbita maxima 0.59 50.0 -21.7 yes 49.2 dialyzate DSC Thermal 2.5 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0, 6.0 1TIN 0.732999986410141, 0.5439999878406525 in pocket 11266603 10.1110/ps.26801 2001 ProTherm 5041758 4889252 67 3C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.816019071161482 0.103354947757668 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.732999986410141 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041759 4889253 68 C3A Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0510512983596894 0.0377769891345025 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.732999986410141 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043059 4890541 68 C3D Inhibitor of trypsin and hageman factor Cucurbita maxima 0.297140976415946 0.0703722768835614 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.732999986410141 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043060 4890542 68 C3E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.419444661144259 0.0643366466274336 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.732999986410141 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043061 4890543 68 C3F Inhibitor of trypsin and hageman factor Cucurbita maxima 0.186785638263932 0.0738838350071807 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.732999986410141 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043062 4890544 68 C3G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.102209568370566 0.0337793532673725 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.732999986410141 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043063 4890545 68 C3H Inhibitor of trypsin and hageman factor Cucurbita maxima 0.102915905152291 0.079757406360631 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.732999986410141 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043064 4890546 68 C3I Inhibitor of trypsin and hageman factor Cucurbita maxima 0.191033015599969 0.0742537104086617 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.732999986410141 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043065 4890547 68 C3K Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0401256151635793 0.0561173821934588 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.732999986410141 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043066 4890548 68 C3L Inhibitor of trypsin and hageman factor Cucurbita maxima 0.175579255697171 0.0359241843559369 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.732999986410141 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043067 4890549 68 C3M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.00418979797795491 0.0525489374634092 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.732999986410141 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043068 4890550 68 C3N Inhibitor of trypsin and hageman factor Cucurbita maxima 0.210957272851373 0.0738948920432874 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.732999986410141 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043069 4890551 68 C3P Inhibitor of trypsin and hageman factor Cucurbita maxima 0.108839381615004 0.0456894815447447 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.732999986410141 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043070 4890552 68 C3Q Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0126998471670199 0.0552166521007835 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.732999986410141 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043071 4890553 68 C3R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0313906466070056 0.0332803381618426 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.732999986410141 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043072 4890554 68 C3S Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0539761498147745 0.0384461332496161 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.732999986410141 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043073 4890555 68 C3T Inhibitor of trypsin and hageman factor Cucurbita maxima 0.111705754034537 0.0413771924792444 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.732999986410141 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043074 4890556 68 C3V Inhibitor of trypsin and hageman factor Cucurbita maxima 0.115025563898967 0.0339720731782288 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.732999986410141 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043075 4890557 68 C3W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.250952524749545 0.0533579364412397 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.732999986410141 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043076 4890558 68 C3Y Inhibitor of trypsin and hageman factor Cucurbita maxima 0.17758283742294 0.0478984056562744 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.732999986410141 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 85 66 68 P4G Inhibitor of trypsin and hageman factor Cucurbita maxima 0.56 45.0 -4.2 yes 66.7 dialyzate DSC Thermal 2.5 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 0.7828571455819267 in pocket 11266603 10.1110/ps.26801 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 5041766 66 68 P4G Inhibitor of trypsin and hageman factor Cucurbita maxima -4.94822608519472E-4 0.0395495786698398 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 0.7828571455819267 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041760 4889254 67 4P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.81838477306894 0.0963469101048273 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 0.7828571455819267 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041761 4889255 68 P4A Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0516630790393134 0.044901714955207 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 0.7828571455819267 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041762 4889256 68 P4C Inhibitor of trypsin and hageman factor Cucurbita maxima 0.10773007929445 0.0769557297479684 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 0.7828571455819267 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041763 4889257 68 P4D Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0484800201503281 0.0711021672214517 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 0.7828571455819267 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041764 4889258 68 P4E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.197055906423121 0.0563649104557897 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 0.7828571455819267 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041765 4889259 68 P4F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.142237838431888 0.0698823935043524 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 0.7828571455819267 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041767 4889260 68 P4H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.220804692599646 0.0762982724431907 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 0.7828571455819267 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041768 4889261 68 P4I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0423856049683083 0.095678899583326 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 0.7828571455819267 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041769 4889262 68 P4K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.443595063343407 0.0612028630734822 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 0.7828571455819267 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041770 4889263 68 P4L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.162762900297781 0.0385544904041071 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 0.7828571455819267 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041771 4889264 68 P4M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0563665928526586 0.0523510713974243 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 0.7828571455819267 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041772 4889265 68 P4N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0776042892425676 0.0825743504999601 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 0.7828571455819267 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043052 4890534 68 P4Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.04140855523585 0.0529010352380822 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 0.7828571455819267 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043053 4890535 68 P4R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0934453602962161 0.0401860195089176 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 0.7828571455819267 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043054 4890536 68 P4S Inhibitor of trypsin and hageman factor Cucurbita maxima 0.00451997960945791 0.0401550256200748 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 0.7828571455819267 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043055 4890537 68 P4T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0612239515133799 0.0524913311150028 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 0.7828571455819267 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043056 4890538 68 P4V Inhibitor of trypsin and hageman factor Cucurbita maxima 0.102945594508802 0.0387290998074916 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 0.7828571455819267 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043057 4890539 68 P4W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.146818366335079 0.0486652457478591 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 0.7828571455819267 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043058 4890540 68 P4Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.335095849779824 0.0820057633356724 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 0.7828571455819267 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041773 4889266 67 5G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.928144020916407 0.114717604300974 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.5700000013623919 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041774 4889267 68 G5A Inhibitor of trypsin and hageman factor Cucurbita maxima 0.15929509348953 0.0475768339381597 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.5700000013623919 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041775 4889268 68 G5C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.530878352711857 0.0736465900583324 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.5700000013623919 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041776 4889269 68 G5D Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0647902730046002 0.0473025132807712 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.5700000013623919 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041777 4889270 68 G5E Inhibitor of trypsin and hageman factor Cucurbita maxima 0.114931997442084 0.052497268986305 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.5700000013623919 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041778 4889271 68 G5F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.00932335762197701 0.0812320766985407 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.5700000013623919 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043038 4890520 68 G5H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.279396007900208 0.121660325369491 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.5700000013623919 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043039 4890521 68 G5I Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0282678661085126 0.0864471921052215 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.5700000013623919 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043040 4890522 68 G5K Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0323982853734452 0.0767604367595478 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.5700000013623919 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043041 4890523 68 G5L Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0259772872698025 0.0406389711279816 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.5700000013623919 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043042 4890524 68 G5M Inhibitor of trypsin and hageman factor Cucurbita maxima 0.107069716031444 0.0670722329331474 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.5700000013623919 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043043 4890525 68 G5N Inhibitor of trypsin and hageman factor Cucurbita maxima 0.107811050266753 0.188155937018543 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.5700000013623919 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043044 4890526 68 G5P Inhibitor of trypsin and hageman factor Cucurbita maxima 0.11407460481314 0.0655106447548575 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.5700000013623919 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043045 4890527 68 G5Q Inhibitor of trypsin and hageman factor Cucurbita maxima 0.106471430513871 0.0685083161043673 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.5700000013623919 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043046 4890528 68 G5R Inhibitor of trypsin and hageman factor Cucurbita maxima 0.123683160193118 0.0365097394373094 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.5700000013623919 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043047 4890529 68 G5S Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0480625698042317 0.0397108188660195 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.5700000013623919 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043048 4890530 68 G5T Inhibitor of trypsin and hageman factor Cucurbita maxima 0.158672516680265 0.0537810547553974 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.5700000013623919 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043049 4890531 68 G5V Inhibitor of trypsin and hageman factor Cucurbita maxima 0.189100508394333 0.0445062167393794 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.5700000013623919 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043050 4890532 68 G5W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0311738243367271 0.0408652310149208 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.5700000013623919 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043051 4890533 68 G5Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.189293579179403 0.0626001161650954 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.5700000013623919 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041779 4889272 67 6K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.831629464911813 0.0941836356281271 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.3118181824684143 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041780 4889273 68 K6A Inhibitor of trypsin and hageman factor Cucurbita maxima 0.247642521369537 0.0501341671467353 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.3118181824684143 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041781 4889274 68 K6C Inhibitor of trypsin and hageman factor Cucurbita maxima 0.143022627088999 0.0544075451616565 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.3118181824684143 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041782 4889275 68 K6D Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0679121538256231 0.0817673847932118 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.3118181824684143 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041783 4889276 68 K6E Inhibitor of trypsin and hageman factor Cucurbita maxima 0.091846273560975 0.0720375888773716 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.3118181824684143 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041784 4889277 68 K6F Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0629162448345163 0.0546149208184997 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.3118181824684143 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041785 4889278 68 K6G Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0690592425999181 0.0438004647480101 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.3118181824684143 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041786 4889279 68 K6H Inhibitor of trypsin and hageman factor Cucurbita maxima 0.112244660839088 0.0707357555782304 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.3118181824684143 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041787 4889280 68 K6I Inhibitor of trypsin and hageman factor Cucurbita maxima 0.110461500093478 0.0646374717830894 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.3118181824684143 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043027 4890509 68 K6L Inhibitor of trypsin and hageman factor Cucurbita maxima 0.108290578358282 0.035204190470217 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.3118181824684143 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043028 4890510 68 K6M Inhibitor of trypsin and hageman factor Cucurbita maxima 0.145529128520518 0.0436205742378765 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.3118181824684143 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043029 4890511 68 K6N Inhibitor of trypsin and hageman factor Cucurbita maxima 0.187823866064353 0.074840354099773 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.3118181824684143 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043030 4890512 68 K6P Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0673606515364913 0.0586954529677188 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.3118181824684143 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043031 4890513 68 K6Q Inhibitor of trypsin and hageman factor Cucurbita maxima 0.152322593096755 0.0686655437390307 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.3118181824684143 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043032 4890514 68 K6R Inhibitor of trypsin and hageman factor Cucurbita maxima 0.205322592856542 0.0402005403032839 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.3118181824684143 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043033 4890515 68 K6S Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0702297229884342 0.0405407983224513 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.3118181824684143 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043034 4890516 68 K6T Inhibitor of trypsin and hageman factor Cucurbita maxima 0.223450194200285 0.0516718778849704 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.3118181824684143 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043035 4890517 68 K6V Inhibitor of trypsin and hageman factor Cucurbita maxima 0.168018366238993 0.0460421731065479 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.3118181824684143 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043036 4890518 68 K6W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0602316072639308 0.0482750106452312 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.3118181824684143 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043037 4890519 68 K6Y Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0964220331735751 0.060056314105669 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.3118181824684143 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041788 4889281 67 7S Inhibitor of trypsin and hageman factor Cucurbita maxima -1.09404747933949 0.130854039468036 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6354545463215221 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041804 4889281 67 7S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.849374793298539 0.113011635882293 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6354545463215221 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041789 4889282 68 S7A Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0929060936206768 0.0458132861613962 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6354545463215221 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041790 4889283 68 S7C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0120331861617237 0.063558785486841 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6354545463215221 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041791 4889284 68 S7D Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0334113222047051 0.0760235019470671 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6354545463215221 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041792 4889285 68 S7E Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0939425220661576 0.0562282944319648 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6354545463215221 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041793 4889286 68 S7F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0899206938718583 0.0563499938033365 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6354545463215221 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041794 4889287 68 S7G Inhibitor of trypsin and hageman factor Cucurbita maxima 0.117453793390593 0.0400400378426296 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6354545463215221 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041795 4889288 68 S7H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0701265299826213 0.0798023902341328 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6354545463215221 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041796 4889289 68 S7I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.254840211033062 0.0746810392133791 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6354545463215221 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041797 4889290 68 S7K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0632371597880781 0.0595490039738655 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6354545463215221 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041798 4889291 68 S7L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0567534541647738 0.0371782897652928 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6354545463215221 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041799 4889292 68 S7M Inhibitor of trypsin and hageman factor Cucurbita maxima 0.00382632828006051 0.0518596225794174 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6354545463215221 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041800 4889293 68 S7N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0519518755071949 0.081614133732966 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6354545463215221 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041801 4889294 68 S7P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.284429073570827 0.0614713988047383 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6354545463215221 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041802 4889295 68 S7Q Inhibitor of trypsin and hageman factor Cucurbita maxima 0.00329191986285947 0.0535785463536671 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6354545463215221 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041803 4889296 68 S7R Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0157146663691084 0.0358146486239601 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6354545463215221 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043023 4890505 68 S7T Inhibitor of trypsin and hageman factor Cucurbita maxima 0.052767882972517 0.0543388727803687 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6354545463215221 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043024 4890506 68 S7V Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0463477845463442 0.0412770763703789 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6354545463215221 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043025 4890507 68 S7W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0657566165751652 0.0473744514912752 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6354545463215221 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043026 4890508 68 S7Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.116342151908617 0.06615760282356 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6354545463215221 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041805 4889297 68 S8A Inhibitor of trypsin and hageman factor Cucurbita maxima 0.191128381411793 0.0520198821271548 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.42363636602054944 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041806 4889298 68 S8C Inhibitor of trypsin and hageman factor Cucurbita maxima 0.10442016588219 0.0596270150072923 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.42363636602054944 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041807 4889299 68 S8D Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0959308092749359 0.0821419835014105 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.42363636602054944 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041808 4889300 68 S8E Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0675135967063973 0.0645425018293524 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.42363636602054944 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041809 4889301 68 S8F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.012676455552799 0.0538839778579694 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.42363636602054944 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041810 4889302 68 S8G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.222825458165093 0.0436733313247194 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.42363636602054944 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041811 4889303 68 S8H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0643227106234228 0.0962092594519119 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.42363636602054944 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041812 4889304 68 S8I Inhibitor of trypsin and hageman factor Cucurbita maxima 0.138431572959409 0.0693094249107857 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.42363636602054944 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041813 4889305 68 S8K Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0544259885497922 0.0676725517218032 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.42363636602054944 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041814 4889306 68 S8L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0254833643387531 0.0398427385734508 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.42363636602054944 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041815 4889307 68 S8M Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0300663213711134 0.0551577592135949 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.42363636602054944 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041816 4889308 68 S8N Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0955925305462026 0.0793264518557093 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.42363636602054944 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041817 4889309 68 S8P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.239489464200582 0.0627208978654476 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.42363636602054944 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041818 4889310 68 S8Q Inhibitor of trypsin and hageman factor Cucurbita maxima 0.162979272729325 0.0624819885132797 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.42363636602054944 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041819 4889311 68 S8R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.148161494830095 0.0428537881269401 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.42363636602054944 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043019 4890501 68 S8T Inhibitor of trypsin and hageman factor Cucurbita maxima 0.129662416658974 0.0512419490123646 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.42363636602054944 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043020 4890502 68 S8V Inhibitor of trypsin and hageman factor Cucurbita maxima 0.145997860482407 0.0456163647567549 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.42363636602054944 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043021 4890503 68 S8W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.108549955372894 0.0596614096769717 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.42363636602054944 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043022 4890504 68 S8Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0247276352639233 0.0623381840664693 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.42363636602054944 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041820 4889312 67 9W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.828353559307921 0.0912133504608052 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.25708332906166714 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041821 4889313 68 W9A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.725701979396326 0.0642107277687275 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.25708332906166714 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041822 4889314 68 W9C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.803842836282023 0.117059554723224 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.25708332906166714 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041823 4889315 68 W9D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.866966366805635 0.130264300886427 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.25708332906166714 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041824 4889316 68 W9E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.654202451626684 0.0943860630588851 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.25708332906166714 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041825 4889317 68 W9F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.260851136145862 0.0714235769976219 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.25708332906166714 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041826 4889318 68 W9G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.820740848427469 0.0765777302589331 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.25708332906166714 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041827 4889319 68 W9H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.92044574171178 0.155417033754942 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.25708332906166714 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041828 4889320 68 W9I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.745689034135139 0.123097560127872 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.25708332906166714 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041829 4889321 68 W9K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.636801699710982 0.0989847644469711 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.25708332906166714 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041830 4889322 68 W9L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.397100991240435 0.0417846654021982 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.25708332906166714 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041831 4889323 68 W9M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.371453705666642 0.0628913867460194 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.25708332906166714 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041832 4889324 68 W9N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.561479082500171 0.123906820012169 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.25708332906166714 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041833 4889325 68 W9P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.903984648932882 0.133023251816038 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.25708332906166714 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041834 4889326 68 W9Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.667733600776016 0.0913315680803679 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.25708332906166714 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041835 4889327 68 W9R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.818539787497027 0.0724856282574493 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.25708332906166714 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041836 4889328 68 W9S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.764348344863673 0.0710599003739095 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.25708332906166714 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041837 4889329 68 W9T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.654672623072524 0.0727098638700809 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.25708332906166714 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041838 4889330 68 W9V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.657748260471587 0.0580799026394953 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.25708332906166714 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043018 4890500 68 W9Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.209171862912088 0.0898683596334264 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.25708332906166714 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041839 4889331 67 10P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.986772510890031 0.138208093075852 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.31857143129621235 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041840 4889332 68 P10A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.130901542438453 0.076692187226671 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.31857143129621235 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041841 4889333 68 P10C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.730991093274917 0.15446832386279 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.31857143129621235 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041842 4889334 68 P10D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.331576491452539 0.219071014114888 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.31857143129621235 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041843 4889335 68 P10E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.145983915481621 0.0732243264377713 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.31857143129621235 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041844 4889336 68 P10F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.542912708454291 0.0988488231812487 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.31857143129621235 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041845 4889337 68 P10G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.3691760821835 0.0556260503335231 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.31857143129621235 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041846 4889338 68 P10H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.751199918510094 0.172931504902857 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.31857143129621235 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041847 4889339 68 P10I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.508654519847042 0.168456509166901 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.31857143129621235 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041848 4889340 68 P10K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.421746935790079 0.0640607065505991 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.31857143129621235 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041849 4889341 68 P10L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.731830222451219 0.0688869723579558 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.31857143129621235 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041850 4889342 68 P10M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.546135623055199 0.084575647044955 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.31857143129621235 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041851 4889343 68 P10N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.143834136166971 0.140616169792149 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.31857143129621235 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043011 4890493 68 P10Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.424214121316157 0.164368824581795 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.31857143129621235 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043012 4890494 68 P10R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.467160315316045 0.0642338674732568 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.31857143129621235 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043013 4890495 68 P10S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.423141885707369 0.0603953665570266 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.31857143129621235 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043014 4890496 68 P10T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.27919627950186 0.0598227938215467 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.31857143129621235 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043015 4890497 68 P10V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.383527197379023 0.0661919255190418 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.31857143129621235 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043016 4890498 68 P10W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.553476361436459 0.0766598618151726 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.31857143129621235 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043017 4890499 68 P10Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.52447579799635 0.134742265558035 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.31857143129621235 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041852 4889344 67 11H Inhibitor of trypsin and hageman factor Cucurbita maxima -1.05498906159087 0.236437848189969 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 1.0423529323409586 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041853 4889345 68 H11A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0240321845795859 0.0424991532618015 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 1.0423529323409586 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041854 4889346 68 H11C Inhibitor of trypsin and hageman factor Cucurbita maxima -8.25004240022474E-4 0.0739678738796567 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 1.0423529323409586 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041855 4889347 68 H11D Inhibitor of trypsin and hageman factor Cucurbita maxima 0.096722525448567 0.0888203793292303 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 1.0423529323409586 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041856 4889348 68 H11E Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0330235612151198 0.0644752779287914 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 1.0423529323409586 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041857 4889349 68 H11F Inhibitor of trypsin and hageman factor Cucurbita maxima 0.00934494988125773 0.0602841304346314 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 1.0423529323409586 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041858 4889350 68 H11G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0556558476513307 0.0546876417484026 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 1.0423529323409586 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042998 4890480 68 H11I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.584467551246769 0.0905349036806515 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 1.0423529323409586 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042999 4890481 68 H11K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.131366045916233 0.0675004344250108 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 1.0423529323409586 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043000 4890482 68 H11L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.189510581385175 0.0415836774553923 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 1.0423529323409586 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043001 4890483 68 H11M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.172255577219619 0.0648906860070308 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 1.0423529323409586 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043002 4890484 68 H11N Inhibitor of trypsin and hageman factor Cucurbita maxima 0.16489738509544 0.0747591851984264 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 1.0423529323409586 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043003 4890485 68 H11P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.505942082242632 0.0800664455715882 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 1.0423529323409586 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043004 4890486 68 H11Q Inhibitor of trypsin and hageman factor Cucurbita maxima 0.207466524267636 0.0845750982416983 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 1.0423529323409586 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043005 4890487 68 H11R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.132541654466328 0.0480749403694448 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 1.0423529323409586 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043006 4890488 68 H11S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.00300582242738835 0.0443500957080041 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 1.0423529323409586 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043007 4890489 68 H11T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.12097369152436 0.0638828313179984 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 1.0423529323409586 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043008 4890490 68 H11V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.466093117901089 0.054048016051081 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 1.0423529323409586 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043009 4890491 68 H11W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.130525837126967 0.0802385718651553 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 1.0423529323409586 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5043010 4890492 68 H11Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.120379454555401 0.0485701768296005 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 1.0423529323409586 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041859 4889351 67 12L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.856925336465811 0.103702313228849 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5547368463717008 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041860 4889352 68 L12A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.819031191331161 0.20390758013167 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5547368463717008 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041861 4889353 68 L12C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.437784946241918 0.100282279294256 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5547368463717008 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041862 4889354 68 L12D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.655731543454756 0.145334708219243 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5547368463717008 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041863 4889355 68 L12E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.649016530753906 0.104382919234931 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5547368463717008 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041864 4889356 68 L12F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.463937400715137 0.0655715889066777 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5547368463717008 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041865 4889357 68 L12G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.906654531792959 0.13420164936629 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5547368463717008 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041866 4889358 68 L12H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.855639787328878 0.160723601376452 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5547368463717008 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041867 4889359 68 L12I Inhibitor of trypsin and hageman factor Cucurbita maxima -1.08083661536949 0.161883375603075 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5547368463717008 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041868 4889360 68 L12K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.802662009602601 0.111158480229514 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5547368463717008 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042988 4890470 68 L12M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.278984855296402 0.0603826901014738 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5547368463717008 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042989 4890471 68 L12N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.848517760540583 0.189899781858713 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5547368463717008 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042990 4890472 68 L12P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.794829957354955 0.0910183003853015 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5547368463717008 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042991 4890473 68 L12Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.920960078324625 0.151303978265181 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5547368463717008 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042992 4890474 68 L12R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.899224509419573 0.108352476168221 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5547368463717008 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042993 4890475 68 L12S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.751394968585598 0.0715130049381434 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5547368463717008 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042994 4890476 68 L12T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.622876581797521 0.0893116752020673 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5547368463717008 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042995 4890477 68 L12V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.402091772069963 0.0568552436737337 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5547368463717008 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042996 4890478 68 L12W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.575724665528459 0.0819864562571654 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5547368463717008 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042997 4890479 68 L12Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.688379039487401 0.0976378573065811 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5547368463717008 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041869 4889361 67 13V Inhibitor of trypsin and hageman factor Cucurbita maxima -1.01588708145914 0.198506186504818 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.34437499940395355 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041870 4889362 68 V13A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.770791205129838 0.120602394632476 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.34437499940395355 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041871 4889363 68 V13C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.385948049515394 0.091767911653335 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.34437499940395355 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041872 4889364 68 V13D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.843178714562405 0.172183243151028 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.34437499940395355 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041873 4889365 68 V13E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.873201491543969 0.222847950101843 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.34437499940395355 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041874 4889366 68 V13F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.667999455468412 0.0957274821667079 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.34437499940395355 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041875 4889367 68 V13G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.337490071463082 0.128312450615185 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.34437499940395355 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041876 4889368 68 V13H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.582303107189358 0.175134095284997 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.34437499940395355 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041877 4889369 68 V13I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.175996526107773 0.109697224082683 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.34437499940395355 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041878 4889370 68 V13K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.666290608081827 0.138839756627564 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.34437499940395355 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041879 4889371 68 V13L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.320127915710844 0.0536176463365148 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.34437499940395355 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041880 4889372 68 V13M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.527050854851085 0.0914135286978881 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.34437499940395355 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041881 4889373 68 V13N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.868252365781304 0.220095476850017 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.34437499940395355 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041882 4889374 68 V13P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.909349605622197 0.124697006734101 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.34437499940395355 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041883 4889375 68 V13Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.850286166575685 0.170554916898011 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.34437499940395355 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041884 4889376 68 V13R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.859773535400449 0.127757799454909 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.34437499940395355 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041885 4889377 68 V13S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.800312951728339 0.0879097797747087 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.34437499940395355 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041886 4889378 68 V13T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.553904068105714 0.0915253586074135 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.34437499940395355 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042986 4890468 68 V13W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.803453905711726 0.168504192072812 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.34437499940395355 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042987 4890469 68 V13Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.992885306482764 0.203384687586085 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.34437499940395355 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041887 4889379 67 14G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.750040324218965 0.106704357010863 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.4299999986376081 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041888 4889380 68 G14A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.761336854468224 0.0967058814153714 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.4299999986376081 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041889 4889381 68 G14C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.717065075683986 0.138550600288694 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.4299999986376081 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041890 4889382 68 G14D Inhibitor of trypsin and hageman factor Cucurbita maxima -1.01239152859772 0.23630631534385 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.4299999986376081 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041891 4889383 68 G14E Inhibitor of trypsin and hageman factor Cucurbita maxima -1.15402339826644 0.269964149175345 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.4299999986376081 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041892 4889384 68 G14F Inhibitor of trypsin and hageman factor Cucurbita maxima -1.15434062454237 0.272563677257265 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.4299999986376081 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042972 4890454 68 G14H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.252291694663692 0.160610961757204 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.4299999986376081 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042973 4890455 68 G14I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.679703359676103 0.106146646947188 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.4299999986376081 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042974 4890456 68 G14K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.815381019899733 0.134645010423524 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.4299999986376081 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042975 4890457 68 G14L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.881094370985364 0.073761595829327 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.4299999986376081 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042976 4890458 68 G14M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.830396996745612 0.106993513349732 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.4299999986376081 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042977 4890459 68 G14N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.648767140159212 0.193176587140076 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.4299999986376081 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042978 4890460 68 G14P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.867328756890566 0.147861902232573 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.4299999986376081 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042979 4890461 68 G14Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.842677504243848 0.146463353605403 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.4299999986376081 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042980 4890462 68 G14R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.888946360085746 0.087813991114474 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.4299999986376081 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042981 4890463 68 G14S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.86018063945564 0.0870851264088995 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.4299999986376081 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042982 4890464 68 G14T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.745759029042308 0.0984250750928621 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.4299999986376081 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042983 4890465 68 G14V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.966963816309976 0.12248631925473 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.4299999986376081 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042984 4890466 68 G14W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.692791057800455 0.15576628854881 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.4299999986376081 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042985 4890467 68 G14Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.70660947396597 0.148576156176034 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.4299999986376081 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041893 4889385 67 15V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.75148286707442 0.0841310534295877 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.4793749935925007 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041894 4889386 68 V15A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.202080335190028 0.0594673582434598 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.4793749935925007 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041895 4889387 68 V15C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.144667327471971 0.0641633237628313 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.4793749935925007 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041896 4889388 68 V15D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.642788063628851 0.155417933432412 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.4793749935925007 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041897 4889389 68 V15E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.318393247580869 0.0820667884584649 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.4793749935925007 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041898 4889390 68 V15F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.267799435214693 0.0617319004161871 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.4793749935925007 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041899 4889391 68 V15G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.657235714216908 0.0776897586022209 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.4793749935925007 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041900 4889392 68 V15H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.083354397856805 0.0800053484745981 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.4793749935925007 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041901 4889393 68 V15I Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0174591409835072 0.0594527474813464 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.4793749935925007 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041902 4889394 68 V15K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.104089534411952 0.0799245574377889 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.4793749935925007 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041903 4889395 68 V15L Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0507319128578267 0.0348218005551278 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.4793749935925007 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041904 4889396 68 V15M Inhibitor of trypsin and hageman factor Cucurbita maxima 0.112500169240578 0.0559439423707854 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.4793749935925007 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041905 4889397 68 V15N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.644501949209268 0.117266030702597 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.4793749935925007 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041906 4889398 68 V15P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.879599547872126 0.0982920127950438 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.4793749935925007 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041907 4889399 68 V15Q Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0370658120879889 0.0570765373410383 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.4793749935925007 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041908 4889400 68 V15R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.14152979226297 0.039492557111789 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.4793749935925007 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041909 4889401 68 V15S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.352648287316974 0.0504129681979246 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.4793749935925007 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041910 4889402 68 V15T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.198579510218626 0.0527202900343521 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.4793749935925007 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042970 4890452 68 V15W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.255402959290569 0.0501895692853401 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.4793749935925007 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042971 4890453 68 V15Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0818984498070466 0.0684688112666581 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.4793749935925007 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041911 4889403 67 16G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.817661612318526 0.0969695768818388 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.6299999867166791 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041917 4889403 67 16G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.874519806934361 0.099465282183717 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.6299999867166791 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041912 4889404 68 G16A Inhibitor of trypsin and hageman factor Cucurbita maxima 0.105986504357522 0.0419085150027232 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.6299999867166791 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041913 4889405 68 G16C Inhibitor of trypsin and hageman factor Cucurbita maxima 0.112172686641485 0.058623748673357 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.6299999867166791 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041914 4889406 68 G16D Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0486356643526442 0.0659137002614334 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.6299999867166791 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041915 4889407 68 G16E Inhibitor of trypsin and hageman factor Cucurbita maxima 0.104970768493852 0.0494044387507896 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.6299999867166791 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041916 4889408 68 G16F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.138364457020144 0.058595282878205 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.6299999867166791 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042956 4890438 68 G16H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0192728907630987 0.0875676414296289 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.6299999867166791 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042957 4890439 68 G16I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.144913659163267 0.0992331653964479 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.6299999867166791 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042958 4890440 68 G16K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.109354356998852 0.0663398414918904 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.6299999867166791 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042959 4890441 68 G16L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0540337291728569 0.0388080914893607 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.6299999867166791 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042960 4890442 68 G16M Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0363019859159288 0.0582441207681008 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.6299999867166791 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042961 4890443 68 G16N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.139769573292846 0.0950980678086711 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.6299999867166791 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042962 4890444 68 G16P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0275724154241753 0.062135225826004 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.6299999867166791 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042963 4890445 68 G16Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0612203528034998 0.0577397345880749 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.6299999867166791 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042964 4890446 68 G16R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.149229861825762 0.0441457159771362 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.6299999867166791 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042965 4890447 68 G16S Inhibitor of trypsin and hageman factor Cucurbita maxima 0.00638771003725132 0.0428528074784977 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.6299999867166791 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042966 4890448 68 G16T Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0481534372287053 0.0503888478449529 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.6299999867166791 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042967 4890449 68 G16V Inhibitor of trypsin and hageman factor Cucurbita maxima 0.00600174840260614 0.0378699348139319 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.6299999867166791 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042968 4890450 68 G16W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.164824601188115 0.0583240031306653 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.6299999867166791 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042969 4890451 68 G16Y Inhibitor of trypsin and hageman factor Cucurbita maxima 0.036891274658802 0.0756894696959924 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.6299999867166791 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041918 4889409 68 G17A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.40513906962872 0.0525536337798027 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.537142847265516 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041919 4889410 68 G17C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.644868297875066 0.115003341865458 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.537142847265516 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041920 4889411 68 G17D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.873438268660533 0.281615512218786 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.537142847265516 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041921 4889412 68 G17E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.960946313205353 0.15029669936973 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.537142847265516 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041922 4889413 68 G17F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.819271945022142 0.135256701135401 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.537142847265516 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042942 4890424 68 G17H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.651203466748068 0.190039591737556 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.537142847265516 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042943 4890425 68 G17I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.95741785778933 0.152874995063357 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.537142847265516 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042944 4890426 68 G17K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.811275791603961 0.147540897311264 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.537142847265516 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042945 4890427 68 G17L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.872546049516724 0.0613438425330367 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.537142847265516 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042946 4890428 68 G17M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.858481598553478 0.098652513557287 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.537142847265516 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042947 4890429 68 G17N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.96083491846982 0.165538675196082 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.537142847265516 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042948 4890430 68 G17P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.783453355810863 0.10054246601859 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.537142847265516 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042949 4890431 68 G17Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.762376341817103 0.0916101082250908 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.537142847265516 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042950 4890432 68 G17R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.902371572212982 0.0784909573763863 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.537142847265516 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042951 4890433 68 G17S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.626978481286653 0.0546449700459989 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.537142847265516 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042952 4890434 68 G17T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.83823741599373 0.085432373912571 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.537142847265516 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042953 4890435 68 G17V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.691932585558547 0.059130294079311 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.537142847265516 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042954 4890436 68 G17W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.253278640848321 0.0570010993851758 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.537142847265516 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042955 4890437 68 G17Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.774796929097424 0.180131893598791 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.537142847265516 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041923 4889414 67 18S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.824885662531922 0.142433428313873 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.5300000039013949 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041924 4889415 68 S18A Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0521264129363816 0.0449858977760782 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.5300000039013949 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041925 4889416 68 S18C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0707620621474543 0.055459924888681 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.5300000039013949 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041926 4889417 68 S18D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0230317432329066 0.0696211991412517 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.5300000039013949 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041927 4889418 68 S18E Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0761091152551157 0.0557488563081829 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.5300000039013949 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041928 4889419 68 S18F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0737803900916761 0.0584318024851249 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.5300000039013949 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041929 4889420 68 S18G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0549136137385515 0.0372383072493188 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.5300000039013949 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041930 4889421 68 S18H Inhibitor of trypsin and hageman factor Cucurbita maxima 0.18674425310031 0.0891882484499531 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.5300000039013949 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041931 4889422 68 S18I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.243181200731126 0.0970650326614095 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.5300000039013949 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041932 4889423 68 S18K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.233202608007722 0.0702189898362168 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.5300000039013949 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041933 4889424 68 S18L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0265638769802656 0.0428544988721414 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.5300000039013949 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041934 4889425 68 S18M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.108069527603895 0.0725020563680521 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.5300000039013949 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041935 4889426 68 S18N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.119573523477744 0.0909371494775044 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.5300000039013949 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041936 4889427 68 S18P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0062329655124054 0.057487761919042 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.5300000039013949 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041937 4889428 68 S18Q Inhibitor of trypsin and hageman factor Cucurbita maxima 0.232178865014569 0.0611707895716754 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.5300000039013949 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041938 4889429 68 S18R Inhibitor of trypsin and hageman factor Cucurbita maxima 5.67696483592313E-4 0.0395663216675571 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.5300000039013949 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042938 4890420 68 S18T Inhibitor of trypsin and hageman factor Cucurbita maxima 0.10544399884309 0.0570187060732644 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.5300000039013949 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042939 4890421 68 S18V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0228446103191392 0.0410863177564073 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.5300000039013949 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042940 4890422 68 S18W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.103287561915162 0.0576671486097924 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.5300000039013949 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042941 4890423 68 S18Y Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0479690033473481 0.0516213969821268 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.5300000039013949 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041939 4889430 67 19V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.842007964270648 0.111228115265695 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.28124999813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041940 4889431 68 V19A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0959853297296201 0.0426417611375768 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.28124999813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041941 4889432 68 V19C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.615361755825809 0.0985034370005022 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.28124999813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041942 4889433 68 V19D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0867729923074455 0.0766750573676415 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.28124999813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041943 4889434 68 V19E Inhibitor of trypsin and hageman factor Cucurbita maxima 0.103246086783794 0.0571902925603495 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.28124999813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041944 4889435 68 V19F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0453554402968952 0.0504388249284134 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.28124999813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041945 4889436 68 V19G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.737965662925873 0.0958537968835009 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.28124999813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041946 4889437 68 V19H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.353407974972671 0.110636037522665 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.28124999813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041947 4889438 68 V19I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0138100491650436 0.0639410134599856 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.28124999813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041948 4889439 68 V19K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0836451736151204 0.0694724914522296 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.28124999813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041949 4889440 68 V19L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.134143800104967 0.0348408827142673 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.28124999813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041950 4889441 68 V19M Inhibitor of trypsin and hageman factor Cucurbita maxima 0.046848904897154 0.0578806150831077 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.28124999813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041951 4889442 68 V19N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.23337651566268 0.0808166236364278 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.28124999813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041952 4889443 68 V19P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.883051187476241 0.103731012940143 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.28124999813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041953 4889444 68 V19Q Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0019666949494974 0.0868472246954981 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.28124999813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041954 4889445 68 V19R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.177522019225965 0.052740559767752 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.28124999813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041955 4889446 68 V19S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.207895400517602 0.0443348371781123 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.28124999813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041956 4889447 68 V19T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.00326582921622857 0.0630455104934111 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.28124999813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042936 4890418 68 V19W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.00616459002468274 0.0659677168967343 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.28124999813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042937 4890419 68 V19Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0974930092339054 0.078540025785602 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.28124999813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041957 4889448 67 20A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.520391712121124 0.0776870145859373 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.28899999856948855 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042917 4890399 68 A20C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.553503081857319 0.0851977110380616 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.28899999856948855 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042918 4890400 68 A20D Inhibitor of trypsin and hageman factor Cucurbita maxima -1.08041862521691 0.217316373145078 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.28899999856948855 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042919 4890401 68 A20E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.775362376387341 0.119053959738798 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.28899999856948855 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042920 4890402 68 A20F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.868275937331019 0.118130530783554 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.28899999856948855 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042921 4890403 68 A20G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.928745995111608 0.110860417083692 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.28899999856948855 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042922 4890404 68 A20H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.962788026310229 0.192172187212528 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.28899999856948855 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042923 4890405 68 A20I Inhibitor of trypsin and hageman factor Cucurbita maxima -1.08392277899495 0.228798866727393 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.28899999856948855 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042924 4890406 68 A20K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.836207923556824 0.133016054396278 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.28899999856948855 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042925 4890407 68 A20L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.778705667833739 0.0494763859580683 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.28899999856948855 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042926 4890408 68 A20M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.608610216219675 0.0820060872195616 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.28899999856948855 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042927 4890409 68 A20N Inhibitor of trypsin and hageman factor Cucurbita maxima -1.07169490262871 0.242909318199681 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.28899999856948855 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042928 4890410 68 A20P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.877808829835767 0.100293255359391 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.28899999856948855 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042929 4890411 68 A20Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.59926760549984 0.0907309434013722 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.28899999856948855 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042930 4890412 68 A20R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.812163413395898 0.0743702366345807 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.28899999856948855 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042931 4890413 68 A20S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.788596452036068 0.0714010130866734 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.28899999856948855 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042932 4890414 68 A20T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.769279926915672 0.115704550485603 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.28899999856948855 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042933 4890415 68 A20V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.529965719886253 0.0549589844733653 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.28899999856948855 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042934 4890416 68 A20W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.915952761423198 0.101765577539104 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.28899999856948855 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042935 4890417 68 A20Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.802503036593646 0.195160915767986 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.28899999856948855 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041958 4889449 67 21K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.846998025358199 0.0882506045906822 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.330909090963277 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041959 4889450 68 K21A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.118658371555224 0.0558049961823131 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.330909090963277 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041960 4889451 68 K21C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.613473332816205 0.102574927391147 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.330909090963277 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041961 4889452 68 K21D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.97795625647404 0.215735279959237 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.330909090963277 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041962 4889453 68 K21E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.980083121003527 0.120344277166323 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.330909090963277 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041963 4889454 68 K21F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.77008495831586 0.106036526424856 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.330909090963277 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041964 4889455 68 K21G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.712263317090913 0.0816582719096459 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.330909090963277 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041965 4889456 68 K21H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.886012943701147 0.188400919193634 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.330909090963277 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041966 4889457 68 K21I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.82939241688257 0.155054913573253 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.330909090963277 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042906 4890388 68 K21L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.568224414331762 0.0473531021449112 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.330909090963277 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042907 4890389 68 K21M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.652183935254912 0.0660332134165529 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.330909090963277 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042908 4890390 68 K21N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.624804050809325 0.108089590411476 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.330909090963277 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042909 4890391 68 K21P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.798986017427784 0.087748926439841 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.330909090963277 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042910 4890392 68 K21Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.188389583257511 0.0678039676098513 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.330909090963277 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042911 4890393 68 K21R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.450592124931114 0.0486905266847671 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.330909090963277 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042912 4890394 68 K21S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.605953648586155 0.0569706093157163 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.330909090963277 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042913 4890395 68 K21T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.642352079926871 0.0984312828674053 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.330909090963277 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042914 4890396 68 K21V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.634803066211298 0.0708023497045624 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.330909090963277 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042915 4890397 68 K21W Inhibitor of trypsin and hageman factor Cucurbita maxima -1.02107364110293 0.111641786966417 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.330909090963277 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042916 4890398 68 K21Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.749139567135966 0.122291719017961 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.330909090963277 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041967 4889458 67 22A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.788287772696099 0.110283273986664 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.22599999904632567 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042887 4890369 68 A22C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.254624558343494 0.0794269278355629 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.22599999904632567 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042888 4890370 68 A22D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0778916462264969 0.0971248612131669 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.22599999904632567 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042889 4890371 68 A22E Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0902178573402109 0.0745649628261951 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.22599999904632567 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042890 4890372 68 A22F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.158211342009125 0.0721714968720117 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.22599999904632567 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042891 4890373 68 A22G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0999987909234481 0.0482882988814637 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.22599999904632567 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042892 4890374 68 A22H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.141557232425806 0.132684973087305 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.22599999904632567 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042893 4890375 68 A22I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.136906259776711 0.112496300627457 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.22599999904632567 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042894 4890376 68 A22K Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0134447801122091 0.0800799587271881 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.22599999904632567 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042895 4890377 68 A22L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0650662040846601 0.0393762288149134 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.22599999904632567 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042896 4890378 68 A22M Inhibitor of trypsin and hageman factor Cucurbita maxima 4.45340347667475E-4 0.0516066872554917 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.22599999904632567 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042897 4890379 68 A22N Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0163903241491051 0.0832551994189588 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.22599999904632567 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042898 4890380 68 A22P Inhibitor of trypsin and hageman factor Cucurbita maxima -1.07093278584385 0.18088735277038 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.22599999904632567 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042899 4890381 68 A22Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.127834092104368 0.0600759720583893 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.22599999904632567 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042900 4890382 68 A22R Inhibitor of trypsin and hageman factor Cucurbita maxima 0.00200088269335873 0.0417689840238955 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.22599999904632567 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042901 4890383 68 A22S Inhibitor of trypsin and hageman factor Cucurbita maxima 0.00369227633702525 0.0481534912093536 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.22599999904632567 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042902 4890384 68 A22T Inhibitor of trypsin and hageman factor Cucurbita maxima 0.00101393650872985 0.0537562596443232 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.22599999904632567 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042903 4890385 68 A22V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0041079273281817 0.0458269432653914 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.22599999904632567 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042904 4890386 68 A22W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.142954971343253 0.0568576907964521 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.22599999904632567 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042905 4890387 68 A22Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.256082305748193 0.116345210812015 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.22599999904632567 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041968 4889459 67 23I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.615510112640618 0.115241216588535 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.19105263289652372 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041976 4889459 67 23I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.952273352669208 0.128950861747923 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.19105263289652372 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041969 4889460 68 I23A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.373474921070823 0.0475506263334575 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.19105263289652372 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041970 4889461 68 I23C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.260581052969358 0.077881344919465 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.19105263289652372 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041971 4889462 68 I23D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.752583532491261 0.156874691191894 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.19105263289652372 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041972 4889463 68 I23E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.195232889965589 0.051068725112284 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.19105263289652372 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041973 4889464 68 I23F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0735710351443989 0.074999363095827 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.19105263289652372 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041974 4889465 68 I23G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.707924442556173 0.065386930105953 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.19105263289652372 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041975 4889466 68 I23H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.229328866724991 0.117869264446255 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.19105263289652372 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042875 4890357 68 I23K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.515470656295524 0.0871206996560647 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.19105263289652372 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042876 4890358 68 I23L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.100245482485732 0.037919471055432 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.19105263289652372 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042877 4890359 68 I23M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.122440705606999 0.0523435770840989 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.19105263289652372 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042878 4890360 68 I23N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.54375102792087 0.155322747556083 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.19105263289652372 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042879 4890361 68 I23P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.959739604154635 0.125211262375973 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.19105263289652372 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042880 4890362 68 I23Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.582058754788496 0.0806532422078694 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.19105263289652372 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042881 4890363 68 I23R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.660421652073798 0.0532606273260807 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.19105263289652372 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042882 4890364 68 I23S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.632816038550978 0.06581487069135 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.19105263289652372 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042883 4890365 68 I23T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.514923562425996 0.114422959929538 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.19105263289652372 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042884 4890366 68 I23V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0600903579011353 0.0377444208100872 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.19105263289652372 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042885 4890367 68 I23W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.219256167738221 0.0582612776174544 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.19105263289652372 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042886 4890368 68 I23Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.122948033732352 0.0837255148131945 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.19105263289652372 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041977 4889467 68 I24A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.730037075285692 0.0880903270493954 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.1563157878423992 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041978 4889468 68 I24C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.678055420454239 0.088521524467234 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.1563157878423992 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041979 4889469 68 I24D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.754226163616052 0.202825358102964 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.1563157878423992 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041980 4889470 68 I24E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.716388878097508 0.14638598134298 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.1563157878423992 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041981 4889471 68 I24F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.985505783005771 0.133938853577293 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.1563157878423992 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041982 4889472 68 I24G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.948188178184243 0.0938190863172688 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.1563157878423992 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041983 4889473 68 I24H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.849618066086437 0.119967582209619 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.1563157878423992 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042863 4890345 68 I24K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.91545024657231 0.131912689947026 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.1563157878423992 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042864 4890346 68 I24L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.638091387364278 0.050735331632213 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.1563157878423992 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042865 4890347 68 I24M Inhibitor of trypsin and hageman factor Cucurbita maxima -1.09544746745061 0.148777593961575 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.1563157878423992 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042866 4890348 68 I24N Inhibitor of trypsin and hageman factor Cucurbita maxima -1.0113643938205 0.228146780497111 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.1563157878423992 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042867 4890349 68 I24P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.776738343110013 0.123368093143112 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.1563157878423992 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042868 4890350 68 I24Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.947723458783871 0.140352564293428 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.1563157878423992 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042869 4890351 68 I24R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.831634323170152 0.0625389830810065 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.1563157878423992 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042870 4890352 68 I24S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.744796734020358 0.061156178809562 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.1563157878423992 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042871 4890353 68 I24T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.627425980860249 0.0733833084435012 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.1563157878423992 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042872 4890354 68 I24V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.297247768131639 0.0490965331334447 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.1563157878423992 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042873 4890355 68 I24W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.846724613375056 0.0851375406088657 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.1563157878423992 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042874 4890356 68 I24Y Inhibitor of trypsin and hageman factor Cucurbita maxima -1.07972884250063 0.184982054839752 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.1563157878423992 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041984 4889474 67 25E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.868497707827383 0.107990086083291 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.49600000580151876 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041985 4889475 68 E25A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.831329062604569 0.107107502485186 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.49600000580151876 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041986 4889476 68 E25C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.766662855123086 0.0941364025609503 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.49600000580151876 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041987 4889477 68 E25D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.917593989051136 0.161870150344265 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.49600000580151876 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042847 4890329 68 E25F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.912307466243658 0.140020223435997 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.49600000580151876 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042848 4890330 68 E25G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.894263013091695 0.0856830330524975 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.49600000580151876 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042849 4890331 68 E25H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.696500248073917 0.122710788783504 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.49600000580151876 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042850 4890332 68 E25I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.573243804904836 0.0988929073772805 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.49600000580151876 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042851 4890333 68 E25K Inhibitor of trypsin and hageman factor Cucurbita maxima -1.00294656157211 0.178907612497567 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.49600000580151876 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042852 4890334 68 E25L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.685970153061381 0.0513332032981503 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.49600000580151876 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042853 4890335 68 E25M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.593962297426788 0.0875235572335972 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.49600000580151876 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042854 4890336 68 E25N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.927082833346951 0.153432705127032 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.49600000580151876 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042855 4890337 68 E25P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.786047845698951 0.0860949053982797 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.49600000580151876 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042856 4890338 68 E25Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.527230610409598 0.0737535347191955 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.49600000580151876 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042857 4890339 68 E25R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.697250039277444 0.0551818255859184 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.49600000580151876 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042858 4890340 68 E25S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.700543218688762 0.0581188676707225 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.49600000580151876 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042859 4890341 68 E25T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.692103704213348 0.0697107620333938 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.49600000580151876 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042860 4890342 68 E25V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.671190251583639 0.0672192132414271 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.49600000580151876 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042861 4890343 68 E25W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.887916607247093 0.095908227370438 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.49600000580151876 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042862 4890344 68 E25Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.66272086781622 0.141245944021174 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.49600000580151876 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041988 4889478 67 26R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.904034212164707 0.171214830322282 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6849999849994978 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041989 4889479 68 R26A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0884685244674742 0.0577218310064212 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6849999849994978 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041990 4889480 68 R26C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.241697722550784 0.148690775085717 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6849999849994978 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041991 4889481 68 R26D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.291404183028265 0.095756271845749 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6849999849994978 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041992 4889482 68 R26E Inhibitor of trypsin and hageman factor Cucurbita maxima 0.024162637812741 0.0846968246033941 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6849999849994978 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041993 4889483 68 R26F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.189447603962273 0.0798635593053205 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6849999849994978 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041994 4889484 68 R26G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0109031912593592 0.0758403636012667 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6849999849994978 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041995 4889485 68 R26H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.396674903990626 0.113471281101734 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6849999849994978 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041996 4889486 68 R26I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.362579826908694 0.1292652990237 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6849999849994978 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041997 4889487 68 R26K Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0863492442190587 0.0965812760857715 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6849999849994978 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041998 4889488 68 R26L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.354134824400713 0.0477313805339623 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6849999849994978 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5041999 4889489 68 R26M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0152216431155292 0.0868687179902572 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6849999849994978 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042000 4889490 68 R26N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.195099917635517 0.134913564148329 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6849999849994978 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042001 4889491 68 R26P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.842560726108238 0.153874536732567 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6849999849994978 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042002 4889492 68 R26Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.315419903510149 0.0915330958336558 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6849999849994978 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042842 4890324 68 R26S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.175315200359716 0.0611699258813042 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6849999849994978 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042843 4890325 68 R26T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.198541543829391 0.0717671818169778 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6849999849994978 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042844 4890326 68 R26V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.317464060689817 0.0649850351833135 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6849999849994978 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042845 4890327 68 R26W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.502510802339664 0.134670021457191 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6849999849994978 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042846 4890328 68 R26Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.280272023852782 0.0933792340021685 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.6849999849994978 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042003 4889493 67 27Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.745605184194932 0.136029344146667 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.3982352912425995 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042004 4889494 68 Q27A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.184822721959809 0.0561163025804948 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.3982352912425995 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042005 4889495 68 Q27C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.393227339925451 0.0554835324254948 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.3982352912425995 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042006 4889496 68 Q27D Inhibitor of trypsin and hageman factor Cucurbita maxima 0.112910422166914 0.0764181454692982 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.3982352912425995 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042007 4889497 68 Q27E Inhibitor of trypsin and hageman factor Cucurbita maxima 0.110668425911586 0.0791715543856933 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.3982352912425995 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042008 4889498 68 Q27F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.325888640519228 0.0590165478567744 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.3982352912425995 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042009 4889499 68 Q27G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.251975098161987 0.0438601133642735 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.3982352912425995 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042010 4889500 68 Q27H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.174610752900678 0.0784928916829468 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.3982352912425995 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042011 4889501 68 Q27I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.374224802242098 0.0754228682712968 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.3982352912425995 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042012 4889502 68 Q27K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.277708842740651 0.0615338993985817 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.3982352912425995 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042013 4889503 68 Q27L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.330073580238845 0.0374616521812551 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.3982352912425995 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042014 4889504 68 Q27M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.197129050201435 0.0588139494872972 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.3982352912425995 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042015 4889505 68 Q27N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0185315565277894 0.0838830123510989 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.3982352912425995 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042016 4889506 68 Q27P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.786455939399359 0.0852901259077837 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.3982352912425995 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042836 4890318 68 Q27R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.476398653417103 0.0407932658140926 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.3982352912425995 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042837 4890319 68 Q27S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0850395837259283 0.0380333882166879 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.3982352912425995 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042838 4890320 68 Q27T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.420760349476438 0.057440744774458 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.3982352912425995 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042839 4890321 68 Q27V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.337270460192646 0.0496422774867682 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.3982352912425995 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042840 4890322 68 Q27W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.447722873543677 0.0497486463540504 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.3982352912425995 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042841 4890323 68 Q27Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.174018495222154 0.126867118759574 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.3982352912425995 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042017 4889507 67 28N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.870649196529225 0.0819909456477409 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.33999999506132944 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042018 4889508 68 N28A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.286259017544879 0.0499606373563149 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.33999999506132944 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042019 4889509 68 N28C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0731553841532424 0.0678266484788709 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.33999999506132944 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042020 4889510 68 N28D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.195512059884541 0.0777467081860742 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.33999999506132944 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042021 4889511 68 N28E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.349104547730251 0.0533540678281186 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.33999999506132944 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042022 4889512 68 N28F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.272139029491409 0.05887436282941 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.33999999506132944 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042023 4889513 68 N28G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.865926789489009 0.0927389335467443 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.33999999506132944 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042024 4889514 68 N28H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.47006204506015 0.140012306274261 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.33999999506132944 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042025 4889515 68 N28I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.309683559961203 0.100425777850727 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.33999999506132944 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042026 4889516 68 N28K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.509104988356289 0.0770858321069103 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.33999999506132944 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042027 4889517 68 N28L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.181075025490629 0.0348113193126019 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.33999999506132944 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042028 4889518 68 N28M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.195215976029152 0.0521567320671219 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.33999999506132944 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042828 4890310 68 N28P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.916106066464092 0.115405677630057 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.33999999506132944 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042829 4890311 68 N28Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.592231857780922 0.073684763373386 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.33999999506132944 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042830 4890312 68 N28R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.409072189624473 0.0416995739070822 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.33999999506132944 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042831 4890313 68 N28S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.292789686332119 0.0481438916507483 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.33999999506132944 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042832 4890314 68 N28T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.397199685858898 0.0586000781591203 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.33999999506132944 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042833 4890315 68 N28V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.215961638810698 0.0481527624706028 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.33999999506132944 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042834 4890316 68 N28W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.486688354609645 0.0666059390972027 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.33999999506132944 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042835 4890317 68 N28Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.148881866580352 0.0717826472726877 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.33999999506132944 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042029 4889519 67 29P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.947955755506634 0.133759008051033 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.29785713979176115 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042030 4889520 68 P29A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.133981228386132 0.0574493366942968 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.29785713979176115 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042031 4889521 68 P29C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.524042783230022 0.0799698831887293 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.29785713979176115 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042032 4889522 68 P29D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.306258307897284 0.0960228462801205 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.29785713979176115 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042033 4889523 68 P29E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.264567523839085 0.072305278911806 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.29785713979176115 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042034 4889524 68 P29F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.857067575473824 0.145904653896511 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.29785713979176115 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042035 4889525 68 P29G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.374324396538031 0.0411102671706596 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.29785713979176115 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042036 4889526 68 P29H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.295823488728826 0.0907177181425627 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.29785713979176115 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042037 4889527 68 P29I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.517187060972858 0.0961407939964422 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.29785713979176115 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042038 4889528 68 P29K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.125946568772233 0.0603504636544971 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.29785713979176115 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042039 4889529 68 P29L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.494097468478628 0.0402258032466425 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.29785713979176115 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042040 4889530 68 P29M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.501700822713391 0.0723462952076649 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.29785713979176115 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042041 4889531 68 P29N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.385202576763723 0.118296881147763 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.29785713979176115 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042821 4890303 68 P29Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.187104753862554 0.075503119501624 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.29785713979176115 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042822 4890304 68 P29R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.183022467342268 0.03518398371424 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.29785713979176115 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042823 4890305 68 P29S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.176312582802997 0.0465646518004963 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.29785713979176115 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042824 4890306 68 P29T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.190480073826885 0.0593647590247769 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.29785713979176115 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042825 4890307 68 P29V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.419674168866865 0.048392625480889 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.29785713979176115 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042826 4890308 68 P29W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.809758395583 0.0700964627615726 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.29785713979176115 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042827 4890309 68 P29Y Inhibitor of trypsin and hageman factor Cucurbita maxima -1.05334975927271 0.242477832885052 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.29785713979176115 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042042 4889532 67 30N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.790210743320552 0.0960831246706129 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.4514285751751491 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042043 4889533 68 N30A Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0384072311958117 0.0782979135816407 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.4514285751751491 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042044 4889534 68 N30C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0102032421876716 0.059326774641992 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.4514285751751491 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042045 4889535 68 N30D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0170758783812722 0.0884150656322047 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.4514285751751491 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042046 4889536 68 N30E Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0158208283105727 0.0830114947858756 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.4514285751751491 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042047 4889537 68 N30F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.102032961683198 0.0610995621063727 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.4514285751751491 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042048 4889538 68 N30G Inhibitor of trypsin and hageman factor Cucurbita maxima 0.107883024464356 0.0473797236012496 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.4514285751751491 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042049 4889539 68 N30H Inhibitor of trypsin and hageman factor Cucurbita maxima 0.105928924999439 0.090370082768141 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.4514285751751491 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042050 4889540 68 N30I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.333250071482299 0.0864297743494016 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.4514285751751491 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042051 4889541 68 N30K Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0763502288170851 0.0503509444331403 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.4514285751751491 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042052 4889542 68 N30L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.05868956008029 0.0344303418911407 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.4514285751751491 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042053 4889543 68 N30M Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0235940416516787 0.0482690637771543 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.4514285751751491 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042813 4890295 68 N30P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.669906861672634 0.0654681349943984 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.4514285751751491 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042814 4890296 68 N30Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0741392714344732 0.0494931829364339 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.4514285751751491 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042815 4890297 68 N30R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0804487994995785 0.0340186764711766 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.4514285751751491 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042816 4890298 68 N30S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0520400438992584 0.0392297973098904 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.4514285751751491 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042817 4890299 68 N30T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0295517058582532 0.0461182948172876 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.4514285751751491 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042818 4890300 68 N30V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.314283340962253 0.0595649102715357 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.4514285751751491 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042819 4890301 68 N30W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.106866928729698 0.04731485685566 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.4514285751751491 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042820 4890302 68 N30Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.16269029632595 0.0820430459700307 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.4514285751751491 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042054 4889544 67 31V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.893234609769247 0.109888945351547 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.25437500327825546 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042055 4889545 68 V31A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.508364373862956 0.0585466013303014 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.25437500327825546 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042056 4889546 68 V31C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.250740200866616 0.0531836059378709 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.25437500327825546 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042057 4889547 68 V31D Inhibitor of trypsin and hageman factor Cucurbita maxima -1.07375012584126 0.20866948301282 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.25437500327825546 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042058 4889548 68 V31E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.938603320308826 0.119507037312708 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.25437500327825546 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042059 4889549 68 V31F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0468713968339049 0.0557721579546568 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.25437500327825546 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042060 4889550 68 V31G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.727883427357921 0.0624663161317517 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.25437500327825546 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042061 4889551 68 V31H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.737687212748897 0.117233822249169 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.25437500327825546 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042062 4889552 68 V31I Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0837743672998173 0.0636567513665532 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.25437500327825546 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042063 4889553 68 V31K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.734997357048985 0.111610028351725 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.25437500327825546 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042064 4889554 68 V31L Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0983356471523405 0.0352639560445514 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.25437500327825546 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042065 4889555 68 V31M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.181492565804473 0.0553147799224402 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.25437500327825546 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042066 4889556 68 V31N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.631306379756259 0.149409347481034 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.25437500327825546 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042067 4889557 68 V31P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.602483592584228 0.0968358848097915 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.25437500327825546 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042068 4889558 68 V31Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.453411174315723 0.071913487367155 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.25437500327825546 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042069 4889559 68 V31R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.800367202279782 0.0563690309786024 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.25437500327825546 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042070 4889560 68 V31S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.763343585065138 0.0570178513796679 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.25437500327825546 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042071 4889561 68 V31T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.468235429892737 0.0582938459418697 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.25437500327825546 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042811 4890293 68 V31W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.412663612117108 0.047000320615361 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.25437500327825546 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042812 4890294 68 V31Y Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0168617551434036 0.0588963149596789 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.25437500327825546 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042072 4889562 67 32K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.937721015610737 0.125769962084865 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.39454545216126874 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042073 4889563 68 K32A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.534118900991177 0.0641997067197195 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.39454545216126874 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042074 4889564 68 K32C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.23517020263469 0.0634038160426274 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.39454545216126874 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042075 4889565 68 K32D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.325016763083017 0.0907099809163204 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.39454545216126874 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042076 4889566 68 K32E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0448309283318646 0.064247461599829 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.39454545216126874 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042077 4889567 68 K32F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.3143990394849 0.0663065804158232 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.39454545216126874 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042078 4889568 68 K32G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.560190384492092 0.0551115697722833 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.39454545216126874 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042079 4889569 68 K32H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.372501560015992 0.0865033409761264 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.39454545216126874 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042080 4889570 68 K32I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.134581043355404 0.0739512748303346 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.39454545216126874 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042800 4890282 68 K32L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.36619734004796 0.0420176548766132 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.39454545216126874 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042801 4890283 68 K32M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.132166758864564 0.0573653607992437 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.39454545216126874 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042802 4890284 68 K32N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.225522331349271 0.0923974159791188 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.39454545216126874 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042803 4890285 68 K32P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.766127636996162 0.0874626580656505 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.39454545216126874 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042804 4890286 68 K32Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.150848741465343 0.0570471448780922 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.39454545216126874 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042805 4890287 68 K32R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.137628520849655 0.0362370471961417 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.39454545216126874 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042806 4890288 68 K32S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.184678413693615 0.041714922404721 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.39454545216126874 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042807 4890289 68 K32T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0607606176163116 0.0523624433206455 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.39454545216126874 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042808 4890290 68 K32V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.10049415333845 0.0462152170711346 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.39454545216126874 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042809 4890291 68 K32W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.575696055784912 0.071092099830562 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.39454545216126874 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042810 4890292 68 K32Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.360740076450219 0.0844646088516033 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.39454545216126874 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042081 4889571 67 33A Inhibitor of trypsin and hageman factor Cucurbita maxima -1.12984096754935 0.171267101583291 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.2669999927282333 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042781 4890263 68 A33C Inhibitor of trypsin and hageman factor Cucurbita maxima 0.104692768155611 0.0542010241984099 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.2669999927282333 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042782 4890264 68 A33D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.651542015380042 0.121973323161316 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.2669999927282333 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042783 4890265 68 A33E Inhibitor of trypsin and hageman factor Cucurbita maxima -1.09303579202443 0.230125081285972 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.2669999927282333 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042784 4890266 68 A33F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.886846665815854 0.126868918114514 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.2669999927282333 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042785 4890267 68 A33G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.090113224850446 0.041303643846069 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.2669999927282333 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042786 4890268 68 A33H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.883390914685701 0.160135212311049 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.2669999927282333 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042787 4890269 68 A33I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.846494385910474 0.186053570706564 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.2669999927282333 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042788 4890270 68 A33K Inhibitor of trypsin and hageman factor Cucurbita maxima -1.01398634186497 0.165941910638152 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.2669999927282333 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042789 4890271 68 A33L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.853391223428018 0.0702868525077815 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.2669999927282333 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042790 4890272 68 A33M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.930092254484219 0.135040508639351 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.2669999927282333 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042791 4890273 68 A33N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.718253279718662 0.129960119933808 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.2669999927282333 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042792 4890274 68 A33P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.622185629500534 0.0809807517972864 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.2669999927282333 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042793 4890275 68 A33Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.999750196453347 0.152877694095767 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.2669999927282333 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042794 4890276 68 A33R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.809478146051084 0.0598353533190284 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.2669999927282333 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042795 4890277 68 A33S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.651203376780321 0.070278341558915 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.2669999927282333 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042796 4890278 68 A33T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.365982587035862 0.0563504706323956 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.2669999927282333 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042797 4890279 68 A33V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0355165674845881 0.0466072515287025 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.2669999927282333 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042798 4890280 68 A33W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.909018047484165 0.101839890898128 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.2669999927282333 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042799 4890281 68 A33Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.632061389089112 0.117495268521962 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.2669999927282333 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042082 4889572 67 34V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.845177977836318 0.185055558489054 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.35937499813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042083 4889573 68 V34A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.313559460469863 0.0811832242119178 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.35937499813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042084 4889574 68 V34C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.22719051331421 0.100598156053986 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.35937499813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042085 4889575 68 V34D Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0519149887309234 0.0776401323929738 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.35937499813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042086 4889576 68 V34E Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0245557968671465 0.0855885939084679 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.35937499813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042087 4889577 68 V34F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.452484506521586 0.0760401459802628 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.35937499813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042088 4889578 68 V34G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.900157106088237 0.137620243816931 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.35937499813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042089 4889579 68 V34H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.264106978942173 0.153179625854711 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.35937499813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042090 4889580 68 V34I Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0946721604943562 0.0624928746106672 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.35937499813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042091 4889581 68 V34K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.225706855198375 0.07758109555739 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.35937499813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042092 4889582 68 V34L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.296381378727995 0.0487479530976795 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.35937499813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042093 4889583 68 V34M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0486392630625245 0.0871030929679761 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.35937499813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042094 4889584 68 V34N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.225744731619863 0.114014686293636 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.35937499813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042095 4889585 68 V34P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.424115156794453 0.123054645512552 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.35937499813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042096 4889586 68 V34Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.297919737234008 0.0854328327480807 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.35937499813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042097 4889587 68 V34R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.393993325323439 0.0667931529819424 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.35937499813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042098 4889588 68 V34S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.127022403090902 0.0476217278439144 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.35937499813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042099 4889589 68 V34T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.138333598082922 0.068003192188816 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.35937499813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042779 4890261 68 V34W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.494767818161551 0.159582090602471 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.35937499813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042780 4890262 68 V34Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.289044778863097 0.0805186414615774 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.35937499813735485 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042100 4889590 67 35I Inhibitor of trypsin and hageman factor Cucurbita maxima NA NA P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.25631579443028096 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042101 4889591 68 I35A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.542560034886038 0.510870425455739 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.25631579443028096 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042102 4889592 68 I35C Inhibitor of trypsin and hageman factor Cucurbita maxima NA NA P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.25631579443028096 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042103 4889593 68 I35D Inhibitor of trypsin and hageman factor Cucurbita maxima NA NA P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.25631579443028096 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042104 4889594 68 I35E Inhibitor of trypsin and hageman factor Cucurbita maxima NA NA P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.25631579443028096 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042105 4889595 68 I35F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.273258408199627 1.14539198258666 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.25631579443028096 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042106 4889596 68 I35G Inhibitor of trypsin and hageman factor Cucurbita maxima NA NA P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.25631579443028096 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042107 4889597 68 I35H Inhibitor of trypsin and hageman factor Cucurbita maxima NA NA P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.25631579443028096 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042767 4890249 68 I35K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.729200015367571 0.802039432793337 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.25631579443028096 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042768 4890250 68 I35L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.323867695018288 0.114826555242596 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.25631579443028096 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042769 4890251 68 I35M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.477021140258621 0.404502277915428 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.25631579443028096 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042770 4890252 68 I35N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0968761003927021 1.02845910245122 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.25631579443028096 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042771 4890253 68 I35P Inhibitor of trypsin and hageman factor Cucurbita maxima NA NA P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.25631579443028096 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042772 4890254 68 I35Q Inhibitor of trypsin and hageman factor Cucurbita maxima NA NA P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.25631579443028096 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042773 4890255 68 I35R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.977105566442248 0.349801167995299 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.25631579443028096 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042774 4890256 68 I35S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.994214444993121 0.746147059935134 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.25631579443028096 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042775 4890257 68 I35T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.724755698633343 0.322328886673539 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.25631579443028096 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042776 4890258 68 I35V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.259006347493555 0.190195775746354 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.25631579443028096 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042777 4890259 68 I35W Inhibitor of trypsin and hageman factor Cucurbita maxima NA NA P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.25631579443028096 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042778 4890260 68 I35Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.661688847790343 0.835340994346698 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.25631579443028096 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042108 4889598 67 36L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.929630396058202 0.0926665095104064 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.23947368483794362 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042109 4889599 68 L36A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.546663193923628 0.0573880146779392 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.23947368483794362 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042110 4889600 68 L36C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0967637306766948 0.0667769138036083 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.23947368483794362 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042111 4889601 68 L36D Inhibitor of trypsin and hageman factor Cucurbita maxima -1.07983374489364 0.288809963043418 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.23947368483794362 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042112 4889602 68 L36E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.702808606558311 0.078917674400424 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.23947368483794362 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042113 4889603 68 L36F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.243886277964393 0.0745257638788257 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.23947368483794362 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042114 4889604 68 L36G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.704758837410107 0.0620678939641465 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.23947368483794362 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042115 4889605 68 L36H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.357862907901046 0.139192610131312 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.23947368483794362 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042116 4889606 68 L36I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0115284671010338 0.0886729581789903 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.23947368483794362 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042117 4889607 68 L36K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.736942909577937 0.0923717751712228 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.23947368483794362 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042757 4890239 68 L36M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.210499067115884 0.0637559498043993 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.23947368483794362 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042758 4890240 68 L36N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.571127673527566 0.115498614312712 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.23947368483794362 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042759 4890241 68 L36P Inhibitor of trypsin and hageman factor Cucurbita maxima -1.00002775594963 0.134216494044546 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.23947368483794362 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042760 4890242 68 L36Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.323956403216833 0.0612951249980343 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.23947368483794362 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042761 4890243 68 L36R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.474574287443366 0.043119687803209 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.23947368483794362 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042762 4890244 68 L36S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.548062102421786 0.0508603418166744 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.23947368483794362 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042763 4890245 68 L36T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.275980832223954 0.0523568833138807 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.23947368483794362 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042764 4890246 68 L36V Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0139108130416875 0.0415106506351495 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.23947368483794362 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042765 4890247 68 L36W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.735574320210519 0.0575870953085087 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.23947368483794362 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042766 4890248 68 L36Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.115875939043645 0.0852644041289154 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.23947368483794362 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042118 4889608 67 37E Inhibitor of trypsin and hageman factor Cucurbita maxima -1.0844272281524 0.20152181541663 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.664000008503596 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042122 4889608 67 37E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.770984455850402 0.0820742107975927 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.664000008503596 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042119 4889609 68 E37A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.168551874978724 0.0424977137778494 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.664000008503596 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042120 4889610 68 E37C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.102185097143381 0.0718268214364665 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.664000008503596 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042121 4889611 68 E37D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.270482453365832 0.0749310056016537 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.664000008503596 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042741 4890223 68 E37F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.294991916843272 0.0761964739374561 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.664000008503596 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042742 4890224 68 E37G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.571035636522381 0.0573670252025633 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.664000008503596 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042743 4890225 68 E37H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.303080017298891 0.131943818787489 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.664000008503596 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042744 4890226 68 E37I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.142109454456914 0.0751176346960379 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.664000008503596 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042745 4890227 68 E37K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.202126398676494 0.0680821478835863 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.664000008503596 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042746 4890228 68 E37L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0618699199368653 0.0367818648816711 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.664000008503596 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042747 4890229 68 E37M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.100880474844083 0.0589283344808375 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.664000008503596 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042748 4890230 68 E37N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.154444932248569 0.0953357625962545 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.664000008503596 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042749 4890231 68 E37P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.163595731731793 0.0619987447537996 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.664000008503596 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042750 4890232 68 E37Q Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0337505006109083 0.0697409642060628 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.664000008503596 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042751 4890233 68 E37R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0940603798147323 0.0413405666094393 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.664000008503596 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042752 4890234 68 E37S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.223839934480305 0.0482088753544089 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.664000008503596 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042753 4890235 68 E37T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.061456967978119 0.0506014056440235 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.664000008503596 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042754 4890236 68 E37V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0747551906304595 0.0405087068270951 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.664000008503596 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042755 4890237 68 E37W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.487362033099208 0.0636724417416306 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.664000008503596 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042756 4890238 68 E37Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.362849100375476 0.113345236288182 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.664000008503596 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 15647 7290 68 E38C, W54C Inhibitor of trypsin and hageman factor Cucurbita maxima 0.33 43.0 2.7 yes 73.6 dialyzate DSC Thermal 2.5 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0, 5.0 1TIN 0.8286666591962178, 0.3258333330353101 in tunnel in pocket 11266603 10.1110/ps.26801 2001 ProTherm 5042123 4889612 68 E38A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.235416714261479 0.0451474708529218 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.8286666591962178 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042124 4889613 68 E38C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.218743531515795 0.0623378241954813 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.8286666591962178 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042125 4889614 68 E38D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.288067819098386 0.0774276015842273 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.8286666591962178 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042725 4890207 68 E38F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.601413696136862 0.0877817196836238 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.8286666591962178 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042726 4890208 68 E38G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.70671725532688 0.0590206503860378 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.8286666591962178 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042727 4890209 68 E38H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.216589973555771 0.0748429721612108 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.8286666591962178 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042728 4890210 68 E38I Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0356992020110051 0.0668157618767644 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.8286666591962178 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042729 4890211 68 E38K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.214238306616846 0.0674858686467709 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.8286666591962178 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042730 4890212 68 E38L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.222624740121528 0.0404814465997531 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.8286666591962178 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042731 4890213 68 E38M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.183630469376518 0.051442891975297 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.8286666591962178 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042732 4890214 68 E38N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.594546637943576 0.122404448604957 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.8286666591962178 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042733 4890215 68 E38P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.413379575447762 0.0626054602492674 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.8286666591962178 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042734 4890216 68 E38Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0579905106860725 0.0602110856208392 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.8286666591962178 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042735 4890217 68 E38R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.324909071689854 0.0405502179455626 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.8286666591962178 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042736 4890218 68 E38S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.332996182500255 0.0385529969395069 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.8286666591962178 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042737 4890219 68 E38T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.275104906239127 0.0490338076202338 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.8286666591962178 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042738 4890220 68 E38V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0844691882099258 0.0427395110946962 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.8286666591962178 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042739 4890221 68 E38W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.235933578968015 0.0451749919867302 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.8286666591962178 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042740 4890222 68 E38Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.328380297272491 0.0611206415494956 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.8286666591962178 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042126 4889615 67 39G Inhibitor of trypsin and hageman factor Cucurbita maxima -1.03135618985958 0.152285436417243 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5014285700661796 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042127 4889616 68 G39A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.589855179808329 0.0637592516207143 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5014285700661796 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042128 4889617 68 G39C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.689913799283534 0.0911186144232105 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5014285700661796 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042129 4889618 68 G39D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.357821252834183 0.069326527779491 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5014285700661796 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042130 4889619 68 G39E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.658688963234256 0.0772826545470299 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5014285700661796 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042131 4889620 68 G39F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.633960248357369 0.0774731072706617 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5014285700661796 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042711 4890193 68 G39H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.499695981439164 0.090624781459908 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5014285700661796 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042712 4890194 68 G39I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.700649290662479 0.105168247698524 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5014285700661796 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042713 4890195 68 G39K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.395315671268897 0.0951779591680103 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5014285700661796 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042714 4890196 68 G39L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.672018584630301 0.0483773399606731 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5014285700661796 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042715 4890197 68 G39M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.899132859275701 0.111182501617964 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5014285700661796 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042716 4890198 68 G39N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.19433060343089 0.0730959064756984 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5014285700661796 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042717 4890199 68 G39P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.957170330426677 0.119220939877237 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5014285700661796 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042718 4890200 68 G39Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.40695344918254 0.091539033704958 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5014285700661796 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042719 4890201 68 G39R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.724342836642344 0.0571451737352273 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5014285700661796 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042720 4890202 68 G39S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.556669496713109 0.0586094797886822 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5014285700661796 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042721 4890203 68 G39T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.741054435615998 0.106788296918817 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5014285700661796 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042722 4890204 68 G39V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.849710013123874 0.0605226529254872 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5014285700661796 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042723 4890205 68 G39W Inhibitor of trypsin and hageman factor Cucurbita maxima -1.02366395648755 0.143774937389443 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5014285700661796 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042724 4890206 68 G39Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.794753304834508 0.143219206616202 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5014285700661796 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042132 4889621 67 40T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.676672886086035 0.0740398300837102 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.7249999982970101 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042133 4889622 68 T40A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.178713642035027 0.0513180077456814 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.7249999982970101 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042134 4889623 68 T40C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.288528094092056 0.0597040184019526 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.7249999982970101 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042135 4889624 68 T40D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.389137496114417 0.105009364657316 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.7249999982970101 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042136 4889625 68 T40E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.31619362613438 0.0773170852038081 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.7249999982970101 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042137 4889626 68 T40F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.557720499933604 0.0864885052946456 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.7249999982970101 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042138 4889627 68 T40G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.591833390629443 0.0705655006138009 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.7249999982970101 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042139 4889628 68 T40H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.165682263720299 0.0713596369198265 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.7249999982970101 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042140 4889629 68 T40I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.316302757011495 0.0784375435249902 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.7249999982970101 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042141 4889630 68 T40K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.257336276205928 0.0670948688182935 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.7249999982970101 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042142 4889631 68 T40L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.379816747557103 0.0389203172569729 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.7249999982970101 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042143 4889632 68 T40M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.28523635416469 0.0567875789312123 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.7249999982970101 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042144 4889633 68 T40N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.644035196537814 0.15523934745461 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.7249999982970101 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042145 4889634 68 T40P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.900853321498424 0.111351011208102 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.7249999982970101 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042146 4889635 68 T40Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.113039525883864 0.0595559674774836 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.7249999982970101 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042147 4889636 68 T40R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.444923796998902 0.0412617098791907 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.7249999982970101 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042148 4889637 68 T40S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.170980644276832 0.0397809217344847 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.7249999982970101 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042708 4890190 68 T40V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.294848778157789 0.050179483900901 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.7249999982970101 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042709 4890191 68 T40W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.635775347653166 0.0564424176698332 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.7249999982970101 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042710 4890192 68 T40Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.337659930569425 0.0772283320213892 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.7249999982970101 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042149 4889638 67 41P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.573276283261505 0.0712558681204326 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 1.0757142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042150 4889639 68 P41A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0957605003298582 0.0417413009481425 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 1.0757142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042151 4889640 68 P41C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.343654931391005 0.109778285022733 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 1.0757142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042152 4889641 68 P41D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0947280304652456 0.0840269247592058 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 1.0757142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042153 4889642 68 P41E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.036608775933211 0.0510058376571285 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 1.0757142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042154 4889643 68 P41F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.233791806782848 0.0778244043323864 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 1.0757142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042155 4889644 68 P41G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.304843565075654 0.0433610532748701 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 1.0757142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042156 4889645 68 P41H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.16255606444742 0.0908947746686657 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 1.0757142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042157 4889646 68 P41I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0776812116662556 0.0773214036556643 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 1.0757142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042158 4889647 68 P41K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0208356305285502 0.0555344631670735 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 1.0757142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042159 4889648 68 P41L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.20897483354615 0.0362478883096556 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 1.0757142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042160 4889649 68 P41M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.115290069075158 0.054978480484141 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 1.0757142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042161 4889650 68 P41N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.214686615900164 0.0790906823779119 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 1.0757142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042701 4890183 68 P41Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0173277880728821 0.0591088997490736 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 1.0757142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042702 4890184 68 P41R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0676444997782876 0.0448812652863131 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 1.0757142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042703 4890185 68 P41S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0900840753004168 0.0469733662783587 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 1.0757142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042704 4890186 68 P41T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0942408551152214 0.0566268695447399 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 1.0757142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042705 4890187 68 P41V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0157974366963518 0.0360574085956997 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 1.0757142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042706 4890188 68 P41W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.400314639163402 0.0563434171610305 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 1.0757142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042707 4890189 68 P41Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.382099679137318 0.0893419853360328 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 2.0 1TIN 1.0757142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 15648 7291 68 V42C, R52C Inhibitor of trypsin and hageman factor Cucurbita maxima 0.15 47.0 16.9 yes 87.8 dialyzate DSC Thermal 2.5 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0, 5.0 1TIN 0.8581250011920929, 0.34833332896232605 in tunnel in pocket 11266603 10.1110/ps.26801 2001 ProTherm 5042162 4889651 67 42V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.860332594980329 0.18681361823325 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.8581250011920929 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042163 4889652 68 V42A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.051750347753907 0.0634881338151191 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.8581250011920929 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042164 4889653 68 V42C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.272069124551987 0.12793971423935 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.8581250011920929 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042165 4889654 68 V42D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.156177980959098 0.0992221893313134 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.8581250011920929 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042166 4889655 68 V42E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.238535896050092 0.0780296207633015 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.8581250011920929 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042167 4889656 68 V42F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.533073385803249 0.107014835705772 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.8581250011920929 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042168 4889657 68 V42G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.614464057646208 0.0776873654601506 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.8581250011920929 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042169 4889658 68 V42H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0729897535310089 0.0976456845005704 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.8581250011920929 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042170 4889659 68 V42I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.535527076167277 0.179108870347614 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.8581250011920929 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042171 4889660 68 V42K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.469525567384768 0.138804849141726 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.8581250011920929 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042172 4889661 68 V42L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.38592024948157 0.0643455174472882 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.8581250011920929 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042173 4889662 68 V42M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.305035376312265 0.0917184293924831 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.8581250011920929 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042174 4889663 68 V42N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.430747849006796 0.245333859013679 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.8581250011920929 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042175 4889664 68 V42P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.472659683819383 0.107241554428221 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.8581250011920929 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042176 4889665 68 V42Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.460209497150298 0.15243595245798 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.8581250011920929 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042177 4889666 68 V42R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.496262272407027 0.0612367089399049 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.8581250011920929 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042178 4889667 68 V42S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.233669990453405 0.0758092977382264 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.8581250011920929 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042179 4889668 68 V42T Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0240906636151381 0.0863620106423586 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.8581250011920929 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042699 4890181 68 V42W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.504620815910138 0.10819998083705 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.8581250011920929 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042700 4890182 68 V42Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.341929350003478 0.0965095717914097 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.8581250011920929 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 86 67 68 T43A Inhibitor of trypsin and hageman factor Cucurbita maxima 0.34 58.0 0.8 yes 71.7 dialyzate DSC Thermal 2.5 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.3064285857336861 in tunnel 11266603 10.1110/ps.26801 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 5042181 67 68 T43A Inhibitor of trypsin and hageman factor Cucurbita maxima 0.00798643690150427 0.0414190724654746 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.3064285857336861 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042180 4889669 67 43T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.791248791185479 0.0698628165226044 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.3064285857336861 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042182 4889670 68 T43C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.34446365146882 0.0608739499872119 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.3064285857336861 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042183 4889671 68 T43D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0569576809504719 0.065469916355789 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.3064285857336861 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042184 4889672 68 T43E Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0666283140758824 0.0519861172317044 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.3064285857336861 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042185 4889673 68 T43F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.360148538513671 0.0553506500631705 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.3064285857336861 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042186 4889674 68 T43G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0797517293957952 0.0480003481104041 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.3064285857336861 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042187 4889675 68 T43H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.163924833750332 0.0638299212859856 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.3064285857336861 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042188 4889676 68 T43I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.142999955216755 0.0519957437806338 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.3064285857336861 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042189 4889677 68 T43K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0544115937102718 0.0530679074152244 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.3064285857336861 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042190 4889678 68 T43L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.230207491742227 0.0331612298615846 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.3064285857336861 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042191 4889679 68 T43M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.117738001503377 0.0481479132090393 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.3064285857336861 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042192 4889680 68 T43N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.172492912136214 0.0777109280130908 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.3064285857336861 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042193 4889681 68 T43P Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0138100491650435 0.0405743652888583 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.3064285857336861 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042194 4889682 68 T43Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0765157694715718 0.0507127407309404 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.3064285857336861 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042195 4889683 68 T43R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.186932465627042 0.0365393298292989 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.3064285857336861 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042196 4889684 68 T43S Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0329102018538953 0.0347945223342363 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.3064285857336861 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042696 4890178 68 T43V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0976740243408765 0.0391183542616771 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.3064285857336861 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042697 4890179 68 T43W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.34130236477461 0.0495891335386132 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.3064285857336861 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042698 4890180 68 T43Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.586721513212449 0.0865565029178308 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.3064285857336861 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042197 4889685 67 44K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.960337061069258 0.095197032330375 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 1.0 1TIN 1.4872727394104004 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042198 4889686 68 K44A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.108060620796941 0.0456362296352933 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 1.0 1TIN 1.4872727394104004 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042199 4889687 68 K44C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.303759003885526 0.0754848290586581 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 1.0 1TIN 1.4872727394104004 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042200 4889688 68 K44D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0453347477150844 0.0745092458004758 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 1.0 1TIN 1.4872727394104004 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042201 4889689 68 K44E Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0298683923277056 0.0473186444978089 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 1.0 1TIN 1.4872727394104004 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042202 4889690 68 K44F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.430937680952973 0.0671066725867004 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 1.0 1TIN 1.4872727394104004 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042203 4889691 68 K44G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0474453910597875 0.0387924011142833 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 1.0 1TIN 1.4872727394104004 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042204 4889692 68 K44H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0862643146658875 0.0900774176871385 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 1.0 1TIN 1.4872727394104004 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042205 4889693 68 K44I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.340594588508933 0.0937069865045024 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 1.0 1TIN 1.4872727394104004 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042685 4890167 68 K44L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.349982902844247 0.0354358754123005 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 1.0 1TIN 1.4872727394104004 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042686 4890168 68 K44M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.234146189738295 0.0453073435393471 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 1.0 1TIN 1.4872727394104004 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042687 4890169 68 K44N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.218192389097651 0.0955849732554543 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 1.0 1TIN 1.4872727394104004 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042688 4890170 68 K44P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0178981835888845 0.0450124472582189 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 1.0 1TIN 1.4872727394104004 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042689 4890171 68 K44Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0227537428946657 0.0457606280390751 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 1.0 1TIN 1.4872727394104004 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042690 4890172 68 K44R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.102196792950492 0.0381186146634244 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 1.0 1TIN 1.4872727394104004 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042691 4890173 68 K44S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0509928193241371 0.0358219090211433 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 1.0 1TIN 1.4872727394104004 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042692 4890174 68 K44T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0485537937028712 0.0460559651621636 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 1.0 1TIN 1.4872727394104004 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042693 4890175 68 K44V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.301420112366675 0.0450100271258245 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 1.0 1TIN 1.4872727394104004 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042694 4890176 68 K44W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.525808220329472 0.0570375633130363 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 1.0 1TIN 1.4872727394104004 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042695 4890177 68 K44Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.241766997715977 0.0669705243951599 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 1.0 1TIN 1.4872727394104004 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042206 4889694 67 45D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.786443343914779 0.0715504135273475 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.8241666853427887 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042207 4889695 68 D45A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.391560777379957 0.0647508761281873 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.8241666853427887 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042208 4889696 68 D45C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.518803061644535 0.0823559807844331 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.8241666853427887 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042668 4890150 68 D45E Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0444296721802287 0.06682955393238 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.8241666853427887 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042669 4890151 68 D45F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.676106898989636 0.0866715896597977 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.8241666853427887 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042670 4890152 68 D45G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.247370638838093 0.0576102979904609 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.8241666853427887 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042671 4890153 68 D45H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.178236812975909 0.0828775777944608 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.8241666853427887 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042672 4890154 68 D45I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.449801668305941 0.074762019182457 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.8241666853427887 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042673 4890155 68 D45K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.430373043372779 0.0560907877274446 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.8241666853427887 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042674 4890156 68 D45L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.48590275624281 0.0373283019866465 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.8241666853427887 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042675 4890157 68 D45M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.390743150495189 0.0532908654858486 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.8241666853427887 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042676 4890158 68 D45N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.127808271360978 0.0628067630831878 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.8241666853427887 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042677 4890159 68 D45P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.464722369307743 0.0515187707731198 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.8241666853427887 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042678 4890160 68 D45Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.174337071014293 0.0480827225795606 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.8241666853427887 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042679 4890161 68 D45R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.501578106706478 0.0496993980093407 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.8241666853427887 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042680 4890162 68 D45S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.272477937994371 0.0369422233939302 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.8241666853427887 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042681 4890163 68 D45T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.301513678823559 0.0461858785888367 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.8241666853427887 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042682 4890164 68 D45V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.524632971650365 0.0522516750305348 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.8241666853427887 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042683 4890165 68 D45W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.460195912020501 0.0596884179946222 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.8241666853427887 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042684 4890166 68 D45Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.402829237692151 0.0843680014848709 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 1.8241666853427887 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042209 4889697 67 46F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.890922645597074 0.100095506251477 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 1.8395000278949738 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042210 4889698 68 F46A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.167893940844887 0.0387699091775324 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 1.8395000278949738 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042211 4889699 68 F46C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.13122920497304 0.0603935042246636 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 1.8395000278949738 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042212 4889700 68 F46D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.154732559135739 0.074611746054637 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 1.8395000278949738 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042213 4889701 68 F46E Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0329093021764253 0.0549016930120735 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 1.8395000278949738 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042653 4890135 68 F46G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.215325206968395 0.0436294000738576 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 1.8395000278949738 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042654 4890136 68 F46H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.128639393407796 0.076051787806725 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 1.8395000278949738 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042655 4890137 68 F46I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.201637334003783 0.0716186720569991 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 1.8395000278949738 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042656 4890138 68 F46K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.201729011137979 0.0534815791159467 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 1.8395000278949738 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042657 4890139 68 F46L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.177286303728816 0.0325975189491846 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 1.8395000278949738 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042658 4890140 68 F46M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0987445505624717 0.0518641209667676 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 1.8395000278949738 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042659 4890141 68 F46N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.157475765709624 0.0977346626023569 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 1.8395000278949738 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042660 4890142 68 F46P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.296305355981777 0.0557984105432325 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 1.8395000278949738 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042661 4890143 68 F46Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.140254859320183 0.0522053506376026 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 1.8395000278949738 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042662 4890144 68 F46R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.280308280854824 0.04296292800083 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 1.8395000278949738 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042663 4890145 68 F46S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.114928848570939 0.0404173715703372 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 1.8395000278949738 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042664 4890146 68 F46T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.152843056513171 0.0448852238671812 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 1.8395000278949738 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042665 4890147 68 F46V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0739217294222186 0.0356337054911866 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 1.8395000278949738 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042666 4890148 68 F46W Inhibitor of trypsin and hageman factor Cucurbita maxima 0.016543269319011 0.0542818422255432 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 1.8395000278949738 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042667 4890149 68 F46Y Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0014475810492869 0.0660766498448062 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 1.8395000278949738 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042214 4889702 67 47R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.697638879879994 0.086807593902943 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 1.0216666708389919 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042215 4889703 68 R47A Inhibitor of trypsin and hageman factor Cucurbita maxima 0.11915508348643 0.0436824810445897 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 1.0216666708389919 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042216 4889704 68 R47C Inhibitor of trypsin and hageman factor Cucurbita maxima 0.00481687317456952 0.053095122658693 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 1.0216666708389919 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042217 4889705 68 R47D Inhibitor of trypsin and hageman factor Cucurbita maxima 0.121539228782024 0.0724770993150333 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 1.0216666708389919 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042218 4889706 68 R47E Inhibitor of trypsin and hageman factor Cucurbita maxima 0.142586283516032 0.060623092918242 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 1.0216666708389919 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042219 4889707 68 R47F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.129726743598081 0.0590650134820852 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 1.0216666708389919 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042220 4889708 68 R47G Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0986190455554016 0.0344925545881936 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 1.0216666708389919 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042221 4889709 68 R47H Inhibitor of trypsin and hageman factor Cucurbita maxima 0.145458054000385 0.0627422831989104 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 1.0216666708389919 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042222 4889710 68 R47I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.204802489311114 0.0667455780373269 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 1.0216666708389919 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042223 4889711 68 R47K Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0844122386260724 0.0794988300589681 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 1.0216666708389919 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042224 4889712 68 R47L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.165618476587674 0.035908359029239 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 1.0216666708389919 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042225 4889713 68 R47M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0106764725369102 0.0649837396477566 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 1.0216666708389919 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042226 4889714 68 R47N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.120903066842962 0.0813977073207743 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 1.0216666708389919 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042227 4889715 68 R47P Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0824293494821144 0.0459885703228832 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 1.0216666708389919 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042228 4889716 68 R47Q Inhibitor of trypsin and hageman factor Cucurbita maxima 0.132293973258827 0.057599393899524 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 1.0216666708389919 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042648 4890130 68 R47S Inhibitor of trypsin and hageman factor Cucurbita maxima 0.021038057959308 0.0393978030806448 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 1.0216666708389919 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042649 4890131 68 R47T Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0649207262377553 0.0526193462222141 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 1.0216666708389919 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042650 4890132 68 R47V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0887793630333715 0.0396848721677837 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 1.0216666708389919 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042651 4890133 68 R47W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0552473940799346 0.041235520268038 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 1.0216666708389919 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042652 4890134 68 R47Y Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0299664571719395 0.0597800231546212 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 1.0216666708389919 in tunnel 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042229 4889717 67 48C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.81024089261018 0.0988380270516083 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.5439999878406525 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042230 4889718 68 C48A Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0183327278069115 0.042341988604561 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.5439999878406525 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042630 4890112 68 C48D Inhibitor of trypsin and hageman factor Cucurbita maxima 0.00859281951630822 0.0706110782744329 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.5439999878406525 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042631 4890113 68 C48E Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0876114917095184 0.0527446622970154 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.5439999878406525 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042632 4890114 68 C48F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0813644912285806 0.0690425175957503 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.5439999878406525 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042633 4890115 68 C48G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.101954059969076 0.0399754499970558 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.5439999878406525 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042634 4890116 68 C48H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0952691864634719 0.0942469729220176 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.5439999878406525 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042635 4890117 68 C48I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.194678508708553 0.0670255396724526 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.5439999878406525 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042636 4890118 68 C48K Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0158361228275632 0.0491573693239685 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.5439999878406525 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042637 4890119 68 C48L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.162337352854455 0.0368966727236223 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.5439999878406525 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042638 4890120 68 C48M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0418170088072459 0.048143720712029 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.5439999878406525 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042639 4890121 68 C48N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.00346555761457643 0.0968631450371336 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.5439999878406525 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042640 4890122 68 C48P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.00928197245835544 0.0474627458381845 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.5439999878406525 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042641 4890123 68 C48Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0131235952554066 0.061827293218335 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.5439999878406525 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042642 4890124 68 C48R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.062751873760741 0.0362573619134151 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.5439999878406525 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042643 4890125 68 C48S Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0156948734647677 0.0388286941034245 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.5439999878406525 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042644 4890126 68 C48T Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0245791884813674 0.0462731922873036 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.5439999878406525 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042645 4890127 68 C48V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0234869800327445 0.0373889222545774 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.5439999878406525 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042646 4890128 68 C48W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.146059398421357 0.0497499688799314 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.5439999878406525 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042647 4890129 68 C48Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.228335442862577 0.0731992794170055 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.5439999878406525 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042231 4889719 67 49N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.646348807119757 0.0662093792619605 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5642857125827244 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042232 4889720 68 N49A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.419907365267098 0.0470517461795482 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5642857125827244 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042233 4889721 68 N49C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.495636546726618 0.0816049570227716 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5642857125827244 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042234 4889722 68 N49D Inhibitor of trypsin and hageman factor Cucurbita maxima 0.1338891014132 0.0727195623932079 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5642857125827244 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042235 4889723 68 N49E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.130783594722132 0.0506797585548889 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5642857125827244 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042236 4889724 68 N49F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.762907331459918 0.106499230547695 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5642857125827244 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042237 4889725 68 N49G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.263063802915667 0.0355294508659589 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5642857125827244 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042238 4889726 68 N49H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.354484439065569 0.0766792768549759 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5642857125827244 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042239 4889727 68 N49I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.840148330940085 0.151013292474613 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5642857125827244 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042240 4889728 68 N49K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.62582203586667 0.0725951010120032 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5642857125827244 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042241 4889729 68 N49L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.732419691129586 0.0497352771468457 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5642857125827244 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042242 4889730 68 N49M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.789308636721348 0.0873491547560308 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5642857125827244 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042622 4890104 68 N49P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.485716523006513 0.0561192625193712 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5642857125827244 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042623 4890105 68 N49Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.401152508791246 0.0608256912877192 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5642857125827244 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042624 4890106 68 N49R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.543662679593313 0.0386867160018782 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5642857125827244 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042625 4890107 68 N49S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.156100608696675 0.0386634863296019 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5642857125827244 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042626 4890108 68 N49T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.119550401766764 0.0471782588253846 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5642857125827244 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042627 4890109 68 N49V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.75216833133884 0.0574184867538493 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5642857125827244 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042628 4890110 68 N49W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.689446326870104 0.0570585977722858 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5642857125827244 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042629 4890111 68 N49Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.604536116764367 0.104689619284466 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.5642857125827244 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 81 62 68 R50A Inhibitor of trypsin and hageman factor Cucurbita maxima 0.13 31.0 -8.3 yes 62.6 dialyzate DSC Thermal 2.5 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5266666685541471 in pocket 11266603 10.1110/ps.26801 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 5042244 62 68 R50A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0150597011709228 0.0542515410883524 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5266666685541471 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 82 63 68 R50K Inhibitor of trypsin and hageman factor Cucurbita maxima 0.23 35.0 -11.7 yes 59.2 dialyzate DSC Thermal 2.5 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5266666685541471 in pocket 11266603 10.1110/ps.26801 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 5042252 63 68 R50K Inhibitor of trypsin and hageman factor Cucurbita maxima 0.00970122215939176 0.0675654990996437 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5266666685541471 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042243 4889731 67 50R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.718358272079415 0.100139770383003 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5266666685541471 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042245 4889732 68 R50C Inhibitor of trypsin and hageman factor Cucurbita maxima 0.140040196275832 0.0865579334050082 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5266666685541471 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042246 4889733 68 R50D Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0413968594287393 0.107307770690016 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5266666685541471 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042247 4889734 68 R50E Inhibitor of trypsin and hageman factor Cucurbita maxima 0.182904429658199 0.0694606157096251 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5266666685541471 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042248 4889735 68 R50F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.172654044371098 0.102932459217739 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5266666685541471 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042249 4889736 68 R50G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0696310775998728 0.0644133981124023 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5266666685541471 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042250 4889737 68 R50H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0575361735637047 0.127662523610832 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5266666685541471 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042251 4889738 68 R50I Inhibitor of trypsin and hageman factor Cucurbita maxima 0.106243812113952 0.0755228674220912 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5266666685541471 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042253 4889739 68 R50L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0120988626170363 0.0432301142158812 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5266666685541471 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042254 4889740 68 R50M Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0505996602697316 0.0605803762319647 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5266666685541471 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042255 4889741 68 R50N Inhibitor of trypsin and hageman factor Cucurbita maxima 0.189628619069244 0.135039429026387 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5266666685541471 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042256 4889742 68 R50P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.563108128495164 0.0691820575713527 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5266666685541471 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042257 4889743 68 R50Q Inhibitor of trypsin and hageman factor Cucurbita maxima 0.200403156450388 0.0682485432316693 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5266666685541471 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042617 4890099 68 R50S Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0176129858308832 0.0433441483352082 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5266666685541471 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042618 4890100 68 R50T Inhibitor of trypsin and hageman factor Cucurbita maxima 0.138338906179995 0.0629743100184325 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5266666685541471 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042619 4890101 68 R50V Inhibitor of trypsin and hageman factor Cucurbita maxima 0.116817721419278 0.0585380903814349 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5266666685541471 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042620 4890102 68 R50W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0238828381195601 0.0683316464395765 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5266666685541471 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042621 4890103 68 R50Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0679272684071197 0.0766905498136755 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.5266666685541471 in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042258 4889744 67 51V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.999811023647097 0.138277098337804 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22500000149011612 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042259 4889745 68 V51A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.372772272966726 0.0531375874352786 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22500000149011612 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042260 4889746 68 V51C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.334366571222613 0.0664091076603084 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22500000149011612 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042261 4889747 68 V51D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.642547939712098 0.141802574471884 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22500000149011612 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042262 4889748 68 V51E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.881454817766959 0.118074300941676 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22500000149011612 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042263 4889749 68 V51F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.959544404732671 0.115174910358993 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22500000149011612 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042264 4889750 68 V51G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.890259367379066 0.0765951300212035 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22500000149011612 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042265 4889751 68 V51H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.812549285062797 0.141680848110189 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22500000149011612 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042266 4889752 68 V51I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.47917874676726 0.0693128706754959 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22500000149011612 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042267 4889753 68 V51K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.933562445437767 0.119495611408838 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22500000149011612 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042268 4889754 68 V51L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.693168292563641 0.0525522302829495 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22500000149011612 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042269 4889755 68 V51M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.602585526041583 0.0677186062114943 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22500000149011612 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042270 4889756 68 V51N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.882096161848249 0.184994020550103 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22500000149011612 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042271 4889757 68 V51P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.833140653158232 0.0818553732497813 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22500000149011612 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042272 4889758 68 V51Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.637698678148607 0.0840707210584471 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22500000149011612 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042273 4889759 68 V51R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.753011329128263 0.0597252867773442 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22500000149011612 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042274 4889760 68 V51S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.74222023768167 0.0577772691321247 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22500000149011612 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042275 4889761 68 V51T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.715548759275988 0.0762732794030731 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22500000149011612 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042615 4890097 68 V51W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.82085339807897 0.102484689740903 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22500000149011612 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042616 4890098 68 V51Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.681892364928446 0.095959958824965 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22500000149011612 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 83 64 68 R52A Inhibitor of trypsin and hageman factor Cucurbita maxima 0.24 43.0 -5.2 yes 65.7 dialyzate DSC Thermal 2.5 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.34833332896232605 in tunnel in pocket 11266603 10.1110/ps.26801 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 5042277 64 68 R52A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.00666661005296245 0.0489988551505229 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.34833332896232605 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 84 65 68 R52Q Inhibitor of trypsin and hageman factor Cucurbita maxima 0.27 42.0 -3.4 yes 67.5 dialyzate DSC Thermal 2.5 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.34833332896232605 in tunnel in pocket 11266603 10.1110/ps.26801 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 5042290 65 68 R52Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0818566148046899 0.0469383328376755 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.34833332896232605 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042276 4889762 67 52R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.844573034705466 0.0943784158003898 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.34833332896232605 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042278 4889763 68 R52C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0397198606245934 0.0587512599611851 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.34833332896232605 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042279 4889764 68 R52D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.273425118434824 0.101148128891418 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.34833332896232605 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042280 4889765 68 R52E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0589873533228718 0.0647041918642672 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.34833332896232605 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042281 4889766 68 R52F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0601263449999367 0.0406917821954726 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.34833332896232605 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042282 4889767 68 R52G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.307935576604672 0.0584242361976019 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.34833332896232605 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042283 4889768 68 R52H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.138004675999877 0.080491660134251 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.34833332896232605 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042284 4889769 68 R52I Inhibitor of trypsin and hageman factor Cucurbita maxima 0.13845766360604 0.0510806818258608 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.34833332896232605 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042285 4889770 68 R52K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.248118720654427 0.0663591215800732 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.34833332896232605 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042286 4889771 68 R52L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.010391274778909 0.033228264829877 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.34833332896232605 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042287 4889772 68 R52M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0419969443012531 0.044633773011081 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.34833332896232605 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042288 4889773 68 R52N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0929304748801149 0.0655867934559213 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.34833332896232605 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042289 4889774 68 R52P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0977197279563544 0.0422282423820244 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.34833332896232605 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042610 4890092 68 R52S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.29065430185699 0.0402580206968445 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.34833332896232605 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042611 4890093 68 R52T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0330181631502997 0.0419368188559306 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.34833332896232605 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042612 4890094 68 R52V Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0508992528672534 0.0378736054980096 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.34833332896232605 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042613 4890095 68 R52W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.213007187966849 0.0448914136481751 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.34833332896232605 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042614 4890096 68 R52Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.246052521376744 0.056993946949289 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.34833332896232605 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042291 4889775 67 53I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.926715036200426 0.116163296027574 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.20157894649003683 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042292 4889776 68 I53A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.758076963123297 0.0797326562334303 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.20157894649003683 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042293 4889777 68 I53C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.655278375913099 0.0908603170215633 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.20157894649003683 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042294 4889778 68 I53D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.544326371662958 0.142555604514304 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.20157894649003683 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042295 4889779 68 I53E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.756346433509684 0.122236838692289 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.20157894649003683 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042296 4889780 68 I53F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.660146620671208 0.150794940752635 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.20157894649003683 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042297 4889781 68 I53G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.791532819362769 0.0854336514545784 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.20157894649003683 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042298 4889782 68 I53H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.295146031593889 0.114028991165409 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.20157894649003683 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042598 4890080 68 I53K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.856265602977034 0.108637943829463 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.20157894649003683 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042599 4890081 68 I53L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.51176182589305 0.0439887132618403 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.20157894649003683 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042600 4890082 68 I53M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.730930455013437 0.0880157347903548 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.20157894649003683 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042601 4890083 68 I53N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.756304328604087 0.178453185407452 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.20157894649003683 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042602 4890084 68 I53P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.866415044451998 0.0898443112546523 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.20157894649003683 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042603 4890085 68 I53Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.897320459012314 0.0970049342064112 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.20157894649003683 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042604 4890086 68 I53R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.936765855031124 0.0611897097888703 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.20157894649003683 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042605 4890087 68 I53S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.865067687472873 0.0728618553818687 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.20157894649003683 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042606 4890088 68 I53T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.833483700177556 0.114477390416475 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.20157894649003683 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042607 4890089 68 I53V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.157586066167451 0.0484028818040474 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.20157894649003683 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042608 4890090 68 I53W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.834899162741163 0.0744231556633681 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.20157894649003683 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042609 4890091 68 I53Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.695129859351559 0.118539254258191 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.20157894649003683 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042299 4889783 67 54W Inhibitor of trypsin and hageman factor Cucurbita maxima -1.00505119507132 0.107427337825783 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.3258333330353101 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042300 4889784 68 W54A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.839241456050289 0.0838145109085304 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.3258333330353101 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042301 4889785 68 W54C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.405565156878528 0.0609142285475454 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.3258333330353101 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042302 4889786 68 W54D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.483686850634113 0.0812414243474544 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.3258333330353101 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042303 4889787 68 W54E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.286794595542791 0.0603009813936452 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.3258333330353101 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042304 4889788 68 W54F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.185309267535604 0.066295955224902 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.3258333330353101 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042305 4889789 68 W54G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.87001222488044 0.060381394565917 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.3258333330353101 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042306 4889790 68 W54H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.282166204798194 0.0910736305497087 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.3258333330353101 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042307 4889791 68 W54I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.230102049542739 0.0628687778511974 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.3258333330353101 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042308 4889792 68 W54K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.745868519790411 0.0878053632075364 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.3258333330353101 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042309 4889793 68 W54L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.356911229073242 0.0408225773060664 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.3258333330353101 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042310 4889794 68 W54M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.155827016778037 0.0539582822202196 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.3258333330353101 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042311 4889795 68 W54N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.575650082266193 0.100695321220749 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.3258333330353101 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042312 4889796 68 W54P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.622111136206015 0.0597646656602077 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.3258333330353101 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042313 4889797 68 W54Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.537935062915826 0.0625850735577964 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.3258333330353101 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042314 4889798 68 W54R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.653905468093825 0.0421923002670965 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.3258333330353101 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042315 4889799 68 W54S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.610303139315041 0.0475831316804499 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.3258333330353101 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042316 4889800 68 W54T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.489067461711407 0.0600721664226911 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.3258333330353101 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042317 4889801 68 W54V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.180193881376477 0.0373602135465086 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.3258333330353101 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042597 4890079 68 W54Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.32059493828554 0.0750430244434478 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.3258333330353101 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042318 4889802 67 55V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.698070095291381 0.114358363087189 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.24062500335276127 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042319 4889803 68 V55A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.86881934252292 0.100908274877907 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.24062500335276127 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042320 4889804 68 V55C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.31288398262536 0.054063868368103 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.24062500335276127 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042321 4889805 68 V55D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.943993575928598 0.177710591623685 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.24062500335276127 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042322 4889806 68 V55E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.839740956981653 0.172759036731851 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.24062500335276127 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042323 4889807 68 V55F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.869647225730847 0.093417200391404 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.24062500335276127 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042324 4889808 68 V55G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.910960541109719 0.0930478827899544 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.24062500335276127 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042325 4889809 68 V55H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.646248942920583 0.170857388463437 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.24062500335276127 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042326 4889810 68 V55I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.169330365893546 0.0582159068826405 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.24062500335276127 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042327 4889811 68 V55K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.958602756408981 0.139285276910725 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.24062500335276127 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042328 4889812 68 V55L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.708337664418161 0.0460680748209103 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.24062500335276127 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042329 4889813 68 V55M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.847268918244427 0.088830986526602 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.24062500335276127 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042330 4889814 68 V55N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.729234023175938 0.177725796172928 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.24062500335276127 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042331 4889815 68 V55P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.868181651132159 0.0941471986905907 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.24062500335276127 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042332 4889816 68 V55Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.89595057410934 0.118451625672609 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.24062500335276127 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042333 4889817 68 V55R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.951981335355983 0.0788535633839093 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.24062500335276127 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042334 4889818 68 V55S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.755269699513546 0.0652584741567813 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.24062500335276127 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042335 4889819 68 V55T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.32834251081875 0.0546907816227731 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.24062500335276127 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042595 4890077 68 V55W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.7002988662879 0.0886046096815917 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.24062500335276127 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042596 4890078 68 V55Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.949313260847621 0.179288356002886 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 8.0 1TIN 0.24062500335276127 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042336 4889820 67 56N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.902544094364636 0.0840538071220104 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.4507142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042337 4889821 68 N56A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.691413291722842 0.0955625712864504 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.4507142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042338 4889822 68 N56C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.690940511212339 0.16011326018078 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.4507142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042339 4889823 68 N56D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0817201337324856 0.0806504172206134 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.4507142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042340 4889824 68 N56E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.644929925781764 0.101063649176982 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.4507142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042341 4889825 68 N56F Inhibitor of trypsin and hageman factor Cucurbita maxima -1.08165073351212 0.177089544266119 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.4507142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042342 4889826 68 N56G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.689846953247511 0.126001359130159 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.4507142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042343 4889827 68 N56H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.948158767727748 0.152978727875652 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.4507142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042344 4889828 68 N56I Inhibitor of trypsin and hageman factor Cucurbita maxima -1.11034882538681 0.204761284082987 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.4507142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042345 4889829 68 N56K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.73558718559834 0.0862519081135756 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.4507142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042346 4889830 68 N56L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.842041162369292 0.0512229118370987 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.4507142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042347 4889831 68 N56M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.682024527548794 0.0606219143407562 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.4507142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042587 4890069 68 N56P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.611829262207462 0.058022233313666 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.4507142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042588 4890070 68 N56Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.908867486459555 0.0974553127479109 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.4507142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042589 4890071 68 N56R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.886076065072444 0.0902071511783176 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.4507142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042590 4890072 68 N56S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.317495279498027 0.0398844566177364 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.4507142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042591 4890073 68 N56T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.785031570028799 0.0797634341996802 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.4507142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042592 4890074 68 N56V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.628959031269189 0.0585503529853515 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.4507142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042593 4890075 68 N56W Inhibitor of trypsin and hageman factor Cucurbita maxima -1.24568127936519 0.22163086642038 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.4507142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042594 4890076 68 N56Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.483501427107539 0.0943366707657801 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 6.0 1TIN 0.4507142901420593 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042348 4889832 67 57K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.278632001792654 0.132311157098505 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7277272777123884 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042349 4889833 68 K57A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.246690572638493 0.0846043107691504 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7277272777123884 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042350 4889834 68 K57C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.472685684498267 0.220257778665611 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7277272777123884 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042351 4889835 68 K57D Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0623854351271955 0.115778144102652 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7277272777123884 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042352 4889836 68 K57E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0144776098478099 0.126823214499036 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7277272777123884 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042353 4889837 68 K57F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.639819397880975 0.144270209836698 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7277272777123884 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042354 4889838 68 K57G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.398415869862892 0.0736842505572281 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7277272777123884 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042355 4889839 68 K57H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.494429269529577 0.282460039459908 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7277272777123884 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042356 4889840 68 K57I Inhibitor of trypsin and hageman factor Cucurbita maxima -1.12418793413413 0.66808357531186 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7277272777123884 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042576 4890058 68 K57L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.512740585012702 0.0831046743814471 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7277272777123884 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042577 4890059 68 K57M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.670071052810915 0.246079151829857 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7277272777123884 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042578 4890060 68 K57N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.106811418629797 0.188729031566955 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7277272777123884 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042579 4890061 68 K57P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.37091569853956 0.110276616373386 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7277272777123884 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042580 4890062 68 K57Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0831595277167952 0.0955897415460455 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7277272777123884 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042581 4890063 68 K57R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.119268532815402 0.0604854872492 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7277272777123884 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042582 4890064 68 K57S Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0243578678237387 0.0503292262190137 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7277272777123884 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042583 4890065 68 K57T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.225358320146483 0.0883157232459634 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7277272777123884 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042584 4890066 68 K57V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.730826632233395 0.10224276646921 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7277272777123884 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042585 4890067 68 K57W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.564272491076884 0.0808133398136622 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7277272777123884 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042586 4890068 68 K57Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.44269574574436 0.1716256230551 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7277272777123884 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042357 4889841 67 58R Inhibitor of trypsin and hageman factor Cucurbita maxima -1.05201580748789 0.20283570439387 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.7266666541496912 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042358 4889842 68 R58A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0136562043176675 0.0604977588498913 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.7266666541496912 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042359 4889843 68 R58C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.135622509994717 0.072274294019738 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.7266666541496912 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042360 4889844 68 R58D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0026540485366045 0.131271309878638 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.7266666541496912 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042361 4889845 68 R58E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.121859513961357 0.0999026154019012 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.7266666541496912 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042362 4889846 68 R58F Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0814891865259275 0.0733638484198244 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.7266666541496912 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042363 4889847 68 R58G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0870471240325652 0.0495551707141193 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.7266666541496912 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042364 4889848 68 R58H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0794659918313119 0.0914717378301994 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.7266666541496912 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042365 4889849 68 R58I Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0120808690676354 0.0876324362010209 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.7266666541496912 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042366 4889850 68 R58K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.108712976930464 0.0830220300090497 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.7266666541496912 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042367 4889851 68 R58L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0657594955430693 0.0447068448151973 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.7266666541496912 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042368 4889852 68 R58M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0359160242812838 0.0741329287083094 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.7266666541496912 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042369 4889853 68 R58N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0639569917318535 0.094536399164128 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.7266666541496912 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042370 4889854 68 R58P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.728060573851771 0.108450810915696 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.7266666541496912 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042371 4889855 68 R58Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.00297883210328726 0.0648468357271413 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.7266666541496912 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042571 4890053 68 R58S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.00600984549983657 0.0552188293202609 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.7266666541496912 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042572 4890054 68 R58T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0762638597799618 0.0759214335380916 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.7266666541496912 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042573 4890055 68 R58V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.122271116403898 0.0630048360749908 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.7266666541496912 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042574 4890056 68 R58W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.122370080925602 0.0637049740789471 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.7266666541496912 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042575 4890057 68 R58Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0561893563910617 0.0923428955244347 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.7266666541496912 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042372 4889856 67 59G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.789187180262893 0.0811838000054986 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.4271428499902998 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042373 4889857 68 G59A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.769735613554245 0.0674757652687824 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.4271428499902998 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042374 4889858 68 G59C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.421104746011968 0.0832036658934752 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.4271428499902998 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042375 4889859 68 G59D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.851624166909121 0.110573240035256 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.4271428499902998 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042376 4889860 68 G59E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.42363517886419 0.071123687506535 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.4271428499902998 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042377 4889861 68 G59F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.838072415145725 0.134517885997008 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.4271428499902998 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042557 4890039 68 G59H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.361128467214033 0.0815432301515525 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.4271428499902998 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042558 4890040 68 G59I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.761003074126841 0.145134889853149 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.4271428499902998 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042559 4890041 68 G59K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.839982340446863 0.132216061189922 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.4271428499902998 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042560 4890042 68 G59L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.960779893116139 0.0708806576315543 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.4271428499902998 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042561 4890043 68 G59M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.749921656760667 0.0730274230266793 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.4271428499902998 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042562 4890044 68 G59N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.679162743484358 0.157382289220488 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.4271428499902998 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042563 4890045 68 G59P Inhibitor of trypsin and hageman factor Cucurbita maxima -1.03760803060531 0.123434219437159 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.4271428499902998 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042564 4890046 68 G59Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.236691287333278 0.0672816328642981 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.4271428499902998 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042565 4890047 68 G59R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.534795728351885 0.0601102767603218 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.4271428499902998 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042566 4890048 68 G59S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.595638036682476 0.057748857317621 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.4271428499902998 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042567 4890049 68 G59T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.954521405553264 0.0999169202736748 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.4271428499902998 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042568 4890050 68 G59V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.960663116779884 0.0791942982321358 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.4271428499902998 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042569 4890051 68 G59W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.801556485927422 0.133945781093812 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.4271428499902998 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042570 4890052 68 G59Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.897622192842215 0.153853574247515 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.4271428499902998 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042378 4889862 67 60L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.898861885418501 0.180810610282186 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2910526300731458 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042379 4889863 68 L60A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.29990793447504 0.127794776198927 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2910526300731458 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042380 4889864 68 L60C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.24414907375339 0.0978544096736186 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2910526300731458 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042381 4889865 68 L60D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.123504394279822 0.158443638731888 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2910526300731458 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042382 4889866 68 L60E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.274458038138172 0.0971911674427085 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2910526300731458 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042383 4889867 68 L60F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0857271172485293 0.0645631044434162 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2910526300731458 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042384 4889868 68 L60G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.504879473182773 0.153096765559721 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2910526300731458 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042385 4889869 68 L60H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.369283593641169 0.128309841550522 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2910526300731458 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042386 4889870 68 L60I Inhibitor of trypsin and hageman factor Cucurbita maxima 0.00657214391860864 0.087385780625836 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2910526300731458 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042387 4889871 68 L60K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.23167981392194 0.0843495311064111 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2910526300731458 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042547 4890029 68 L60M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.180129014630887 0.0844920040305659 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2910526300731458 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042548 4890030 68 L60N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.377704034954219 0.111688570194859 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2910526300731458 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042549 4890031 68 L60P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.967116337731793 0.218673806511867 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2910526300731458 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042550 4890032 68 L60Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0879981730861398 0.10449762811236 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2910526300731458 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042551 4890033 68 L60R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.138577860516037 0.0597490562561026 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2910526300731458 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042552 4890034 68 L60S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.229586894223397 0.0639486157346073 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2910526300731458 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042553 4890035 68 L60T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.154387892696969 0.0918410554316489 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2910526300731458 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042554 4890036 68 L60V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.069406158232364 0.0771653635952614 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2910526300731458 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042555 4890037 68 L60W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.368736859642629 0.0960053925372018 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2910526300731458 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042556 4890038 68 L60Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.106329371441352 0.0819225251761447 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2910526300731458 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042388 4889872 67 61V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.742638587705237 0.0863724828881098 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22875000163912773 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042406 4889872 67 61V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.769227655654663 0.0790323203004307 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22875000163912773 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042389 4889873 68 V61A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.817948159592732 0.0779280561737092 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22875000163912773 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042390 4889874 68 V61C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.200953489158809 0.0929084327820989 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22875000163912773 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042391 4889875 68 V61D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.849505426467188 0.119432993856924 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22875000163912773 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042392 4889876 68 V61E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.927751608594302 0.0836084217904694 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22875000163912773 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042393 4889877 68 V61F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.90656158611353 0.133950099545668 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22875000163912773 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042394 4889878 68 V61G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.73318099820473 0.0578281368962806 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22875000163912773 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042395 4889879 68 V61H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.90559435186227 0.149319019863042 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22875000163912773 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042396 4889880 68 V61I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.583224017047686 0.0996075211917296 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22875000163912773 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042397 4889881 68 V61K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.800071028456646 0.112043762860029 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22875000163912773 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042398 4889882 68 V61L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.757345075501424 0.057040424287391 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22875000163912773 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042399 4889883 68 V61M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.943108923072312 0.164531756171618 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22875000163912773 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042400 4889884 68 V61N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.990377563496337 0.198887019977884 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22875000163912773 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042401 4889885 68 V61P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.812487747123846 0.0995332078327047 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22875000163912773 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042402 4889886 68 V61Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.735148862734939 0.0940359085875473 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22875000163912773 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042403 4889887 68 V61R Inhibitor of trypsin and hageman factor Cucurbita maxima -1.02487951971409 0.104069021765635 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22875000163912773 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042404 4889888 68 V61S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.822628641662844 0.0685359092123733 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22875000163912773 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042405 4889889 68 V61T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.478697599256285 0.0633269386028129 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22875000163912773 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042545 4890027 68 V61W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.822247718222031 0.0926222453788807 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22875000163912773 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042546 4890028 68 V61Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.850566775978589 0.144327159420551 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.22875000163912773 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042407 4889890 68 V62A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.291105939946948 0.0506664343315577 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.2512499988079071 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042408 4889891 68 V62C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.116985151396452 0.0685016135072156 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.2512499988079071 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042409 4889892 68 V62D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.646618980264008 0.131510264214679 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.2512499988079071 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042410 4889893 68 V62E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.791140020179352 0.0820054484485579 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.2512499988079071 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042411 4889894 68 V62F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.844880814367965 0.10052357279172 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.2512499988079071 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042412 4889895 68 V62G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.839434976674094 0.0623674595713442 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.2512499988079071 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042413 4889896 68 V62H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.728017479300956 0.196188167503272 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.2512499988079071 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042414 4889897 68 V62I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.146163401136893 0.0642972857381196 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.2512499988079071 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042415 4889898 68 V62K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.299288776440161 0.0557218120034336 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.2512499988079071 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042416 4889899 68 V62L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.321853767001613 0.036701100835186 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.2512499988079071 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042417 4889900 68 V62M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.180650917531255 0.0513537699251153 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.2512499988079071 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042418 4889901 68 V62N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.322026145204872 0.0907431790149647 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.2512499988079071 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042419 4889902 68 V62P Inhibitor of trypsin and hageman factor Cucurbita maxima -1.02129855147366 0.139941231754128 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.2512499988079071 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042420 4889903 68 V62Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.220568527263762 0.0604123974515344 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.2512499988079071 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042421 4889904 68 V62R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.656918667876468 0.0617909282549961 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.2512499988079071 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042422 4889905 68 V62S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.148022044822239 0.0442851929753158 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.2512499988079071 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042423 4889906 68 V62T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0563593954328984 0.059878420879519 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.2512499988079071 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042543 4890025 68 V62W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.950918303447714 0.12218906581863 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.2512499988079071 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042544 4890026 68 V62Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.974132402307022 0.164364955968673 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.2512499988079071 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042424 4889907 67 63S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.985783441466573 0.124024407857503 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.3436363691633398 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042425 4889908 68 S63A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.079088397197138 0.0579376906218068 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.3436363691633398 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042426 4889909 68 S63C Inhibitor of trypsin and hageman factor Cucurbita maxima 0.00111380070790378 0.0556279036691113 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.3436363691633398 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042427 4889910 68 S63D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.158053898451869 0.061649786853497 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.3436363691633398 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042428 4889911 68 S63E Inhibitor of trypsin and hageman factor Cucurbita maxima 0.0220735867273188 0.0595603399099879 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.3436363691633398 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042429 4889912 68 S63F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.349827618512918 0.0549217468228805 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.3436363691633398 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042430 4889913 68 S63G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.380063978925869 0.0604672687804318 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.3436363691633398 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042431 4889914 68 S63H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0875622793519076 0.0634858126472464 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.3436363691633398 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042432 4889915 68 S63I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.185197617561573 0.0533404287176728 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.3436363691633398 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042433 4889916 68 S63K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.00932965536426731 0.0616516941697334 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.3436363691633398 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042434 4889917 68 S63L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.125938831545991 0.036692391957276 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.3436363691633398 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042435 4889918 68 S63M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.271674526013629 0.062235566854237 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.3436363691633398 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042436 4889919 68 S63N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.206632883123901 0.0689323430927697 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.3436363691633398 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042437 4889920 68 S63P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.84745497154523 0.10277330627329 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.3436363691633398 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042438 4889921 68 S63Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0531394497676417 0.0592123896484517 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.3436363691633398 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042439 4889922 68 S63R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0309579017439185 0.0436035163530447 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.3436363691633398 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042539 4890021 68 S63T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.057898743584129 0.0566858973835489 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.3436363691633398 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042540 4890022 68 S63V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0873376298876397 0.0385898747190036 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.3436363691633398 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042541 4890023 68 S63W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.344876063621085 0.0786480320658797 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.3436363691633398 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042542 4890024 68 S63Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0842801659734713 0.0501212477782656 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 4.0 1TIN 0.3436363691633398 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042440 4889923 67 64P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.989133651432716 0.104053367377657 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2692857107945851 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042453 4889923 67 64P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.970200268357775 0.172872216157581 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2692857107945851 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042441 4889924 68 P64A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.167295745295061 0.0625101844051906 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2692857107945851 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042442 4889925 68 P64C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.385141938502242 0.07051433595608 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2692857107945851 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042443 4889926 68 P64D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.642535434195265 0.118432822413486 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2692857107945851 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042444 4889927 68 P64E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.195477602237438 0.0518294743873965 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2692857107945851 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042445 4889928 68 P64F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.739601366534144 0.10736858888699 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2692857107945851 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042446 4889929 68 P64G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.648826878743222 0.0771054630693064 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2692857107945851 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042447 4889930 68 P64H Inhibitor of trypsin and hageman factor Cucurbita maxima -1.06176444264996 0.232790285823205 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2692857107945851 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042448 4889931 68 P64I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.277804118584728 0.0698461095119859 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2692857107945851 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042449 4889932 68 P64K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.543594843912072 0.0791087389047355 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2692857107945851 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042450 4889933 68 P64L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.813013698572829 0.054589271013829 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2692857107945851 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042451 4889934 68 P64M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.568975645019241 0.0561506252759766 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2692857107945851 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042452 4889935 68 P64N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.687345040171089 0.155310781845731 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2692857107945851 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042532 4890014 68 P64Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.492344986734746 0.0645706077535163 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2692857107945851 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042533 4890015 68 P64R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.791753150375181 0.067654873059517 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2692857107945851 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042534 4890016 68 P64S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.36370019526213 0.0487630766759507 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2692857107945851 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042535 4890017 68 P64T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.124153691509947 0.0640593660311687 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2692857107945851 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042536 4890018 68 P64V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0978471222861114 0.0463549639725552 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2692857107945851 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042537 4890019 68 P64W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.990637192420639 0.119130792194739 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2692857107945851 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042538 4890020 68 P64Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.509404760889305 0.104090703992663 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 1TIN 0.2692857107945851 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042454 4889936 68 P65A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.88097318443015 0.11905449954528 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.2799999990633556 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042455 4889937 68 P65C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.722440108760966 0.147752141581229 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.2799999990633556 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042456 4889938 68 P65D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.796747529914589 0.231404512616109 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.2799999990633556 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042457 4889939 68 P65E Inhibitor of trypsin and hageman factor Cucurbita maxima -1.16215684246654 0.243102209049257 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.2799999990633556 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042458 4889940 68 P65F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.721678891653569 0.160560579818882 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.2799999990633556 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042459 4889941 68 P65G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.526646539796051 0.0884265994973705 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.2799999990633556 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042460 4889942 68 P65H Inhibitor of trypsin and hageman factor Cucurbita maxima -1.17475871475708 0.258231005449878 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.2799999990633556 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042461 4889943 68 P65I Inhibitor of trypsin and hageman factor Cucurbita maxima -1.00397340845254 0.187330662875279 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.2799999990633556 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042462 4889944 68 P65K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.852947142628809 0.147742694967793 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.2799999990633556 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042463 4889945 68 P65L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.687304914555926 0.0771376535291843 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.2799999990633556 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042464 4889946 68 P65M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.495849230480534 0.115207838554397 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.2799999990633556 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042465 4889947 68 P65N Inhibitor of trypsin and hageman factor Cucurbita maxima -1.07672643884763 0.340701290256879 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.2799999990633556 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042525 4890007 68 P65Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.85427119796146 0.138343584502839 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.2799999990633556 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042526 4890008 68 P65R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.90514322658847 0.0868914078560515 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.2799999990633556 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042527 4890009 68 P65S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.952148531417015 0.101587261464543 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.2799999990633556 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042528 4890010 68 P65T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.692109192245915 0.114627906457212 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.2799999990633556 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042529 4890011 68 P65V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.989951953075587 0.149349428961529 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.2799999990633556 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042530 4890012 68 P65W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.891236255169579 0.131240450941416 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.2799999990633556 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042531 4890013 68 P65Y Inhibitor of trypsin and hageman factor Cucurbita maxima -1.13012985398498 0.279835950183056 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 0.2799999990633556 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042466 4889948 67 66R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.696387698422415 0.162813552139344 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7266666616002718 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042467 4889949 68 R66A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.068240626069933 0.0555339863380144 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7266666616002718 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042468 4889950 68 R66C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.124104389184589 0.0666193712818304 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7266666616002718 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042469 4889951 68 R66D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.492984657415941 0.117335305867789 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7266666616002718 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042470 4889952 68 R66E Inhibitor of trypsin and hageman factor Cucurbita maxima 0.00549433030950619 0.0715199144611133 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7266666616002718 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042471 4889953 68 R66F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.279962084964355 0.0619451599636843 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7266666616002718 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042472 4889954 68 R66G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.31506678010316 0.0427518186824862 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7266666616002718 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042473 4889955 68 R66H Inhibitor of trypsin and hageman factor Cucurbita maxima 0.137660549367588 0.144384019036657 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7266666616002718 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042474 4889956 68 R66I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0292881003595328 0.0659544376572766 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7266666616002718 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042475 4889957 68 R66K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0657430314453677 0.0931185974390992 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7266666616002718 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042476 4889958 68 R66L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0817643978640114 0.042292659288879 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7266666616002718 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042477 4889959 68 R66M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.091867595917015 0.070683313378502 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7266666616002718 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042478 4889960 68 R66N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.295162855562579 0.111955144629231 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7266666616002718 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042479 4889961 68 R66P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.370828159921726 0.0794585964825081 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7266666616002718 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042480 4889962 68 R66Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0785345557465843 0.0730158351808653 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7266666616002718 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042520 4890002 68 R66S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0785872768463283 0.0411190210324431 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7266666616002718 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042521 4890003 68 R66T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.00195499914238698 0.0557940561042775 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7266666616002718 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042522 4890004 68 R66V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.00559599386362036 0.0516856519470367 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7266666616002718 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042523 4890005 68 R66W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.478132961676091 0.0789147864357452 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7266666616002718 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042524 4890006 68 R66Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0861604918858453 0.0713760650304293 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 3.0 1TIN 0.7266666616002718 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042481 4889963 67 67I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.627046406935641 0.123701783516748 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.47157894310198334 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042482 4889964 68 I67A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0472231707246887 0.0480467534743085 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.47157894310198334 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042483 4889965 68 I67C Inhibitor of trypsin and hageman factor Cucurbita maxima 0.100673908896963 0.0621850859513933 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.47157894310198334 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042484 4889966 68 I67D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.450239721266101 0.0793111033580705 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.47157894310198334 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042485 4889967 68 I67E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.430047989902855 0.120337349649804 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.47157894310198334 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042486 4889968 68 I67F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.396679222442483 0.0540343139632123 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.47157894310198334 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042487 4889969 68 I67G Inhibitor of trypsin and hageman factor Cucurbita maxima -0.46938827660284 0.0641978443873566 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.47157894310198334 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042488 4889970 68 I67H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.691419949336121 0.140593228016663 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.47157894310198334 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042508 4889990 68 I67K Inhibitor of trypsin and hageman factor Cucurbita maxima 0.11888967863277 0.108988638107283 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.47157894310198334 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042509 4889991 68 I67L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0378143437430584 0.0427076715090316 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.47157894310198334 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042510 4889992 68 I67M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0734162006518058 0.0758429456756057 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.47157894310198334 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042511 4889993 68 I67N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.28943110036873 0.102539480098828 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.47157894310198334 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042512 4889994 68 I67P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.633183196926499 0.0695549648859077 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.47157894310198334 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042513 4889995 68 I67Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.172316845255329 0.0773173551070492 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.47157894310198334 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042514 4889996 68 I67R Inhibitor of trypsin and hageman factor Cucurbita maxima 0.00112639619248426 0.0542092382537113 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.47157894310198334 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042515 4889997 68 I67S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.239729768052829 0.0480909816187355 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.47157894310198334 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042516 4889998 68 I67T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0449083005942876 0.0585906855263332 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.47157894310198334 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042517 4889999 68 I67V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0639168661166898 0.0442885847593778 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.47157894310198334 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042518 4890000 68 I67W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.480693623691305 0.120383593071763 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.47157894310198334 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042519 4890001 68 I67Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.322292089865015 0.0885496933688208 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 1TIN 0.47157894310198334 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042489 4889971 68 G68A Inhibitor of trypsin and hageman factor Cucurbita maxima -0.273458946307698 0.0661891545124341 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 1.282499998807907 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042490 4889972 68 G68C Inhibitor of trypsin and hageman factor Cucurbita maxima -0.170729364359451 0.0669942578868194 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 1.282499998807907 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042491 4889973 68 G68D Inhibitor of trypsin and hageman factor Cucurbita maxima -0.0612734337742318 0.0669968489579331 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 1.282499998807907 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042492 4889974 68 G68E Inhibitor of trypsin and hageman factor Cucurbita maxima -0.129737989566457 0.157562494617736 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 1.282499998807907 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042493 4889975 68 G68F Inhibitor of trypsin and hageman factor Cucurbita maxima -0.558827912931471 0.126702657718051 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 1.282499998807907 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042494 4889976 68 G68H Inhibitor of trypsin and hageman factor Cucurbita maxima -0.578697649728191 0.184461411487843 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 1.282499998807907 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042495 4889977 68 G68I Inhibitor of trypsin and hageman factor Cucurbita maxima -0.379199658780406 0.103889716045857 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 1.282499998807907 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042496 4889978 68 G68K Inhibitor of trypsin and hageman factor Cucurbita maxima -0.776854851342383 0.216509272486709 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 1.282499998807907 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042497 4889979 68 G68L Inhibitor of trypsin and hageman factor Cucurbita maxima -0.424814116220924 0.0749459042605575 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 1.282499998807907 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042498 4889980 68 G68M Inhibitor of trypsin and hageman factor Cucurbita maxima -0.322520068135922 0.113034937528767 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 1.282499998807907 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042499 4889981 68 G68N Inhibitor of trypsin and hageman factor Cucurbita maxima -0.220887103055901 0.105679354469252 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 1.282499998807907 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042500 4889982 68 G68P Inhibitor of trypsin and hageman factor Cucurbita maxima -0.301708908834556 0.0793750434358659 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 1.282499998807907 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042501 4889983 68 G68Q Inhibitor of trypsin and hageman factor Cucurbita maxima -0.549803248229546 0.16991362679737 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 1.282499998807907 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042502 4889984 68 G68R Inhibitor of trypsin and hageman factor Cucurbita maxima -0.574371460645779 0.0683789964648244 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 1.282499998807907 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042503 4889985 68 G68S Inhibitor of trypsin and hageman factor Cucurbita maxima -0.235410776390177 0.0515993638808856 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 1.282499998807907 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042504 4889986 68 G68T Inhibitor of trypsin and hageman factor Cucurbita maxima -0.257672845547468 0.0646323256279608 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 1.282499998807907 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042505 4889987 68 G68V Inhibitor of trypsin and hageman factor Cucurbita maxima -0.179590827568312 0.0569184010321301 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 1.282499998807907 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042506 4889988 68 G68W Inhibitor of trypsin and hageman factor Cucurbita maxima -0.415502004567322 0.0840564521737723 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 1.282499998807907 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5042507 4889989 68 G68Y Inhibitor of trypsin and hageman factor Cucurbita maxima -0.382577048002918 0.129009070880234 P19873 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 9.0 1TIN 1.282499998807907 in tunnel in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 18222 76 100 Pancreatic trypsin inhibitor Bos taurus 70.0 Unknown 87.0 glycine-HCl 10 mM NaCl 0.1 N DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 7686069 10.1002/pro.5560020410 1993 ProTherm 18282 76 100 Pancreatic trypsin inhibitor Bos taurus 43.0 Unknown 39.2 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 7540212 10.1006/jmbi.1995.0304 1995 ProTherm 18283 76 100 Pancreatic trypsin inhibitor Bos taurus 70.0 Unknown 87.0 glycine-HCl 10 mM NaCl 0.1 N DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 7690587 10.1021/bi00088a012 1993 ProTherm 18289 76 100 Pancreatic trypsin inhibitor Bos taurus 70.0 70.0 no 104.0 Potassium phosphate 10 mM NaCl 0.1 M DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9154914 10.1021/bi962423c 1997 ProTherm 18295 76 100 Pancreatic trypsin inhibitor Bos taurus 67.2 67.9 yes 86.0 glycine-HCl 10 mM DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 7507751 10.1002/pro.5560021204 1993 ProTherm 18296 76 100 Pancreatic trypsin inhibitor Bos taurus 69.4 70.1 yes 90.0 glycine-HCl 10 mM DSC Thermal 2.5 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 7507751 10.1002/pro.5560021204 1993 ProTherm 18297 76 100 Pancreatic trypsin inhibitor Bos taurus 71.8 74.6 yes 100.5 glycine-HCl 10 mM DSC Thermal 3.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 7507751 10.1002/pro.5560021204 1993 ProTherm 18298 76 100 Pancreatic trypsin inhibitor Bos taurus 77.3 75.8 yes 101.5 Sodium acetate-Acetic acid 10 mM DSC Thermal 3.5 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 7507751 10.1002/pro.5560021204 1993 ProTherm 18299 76 100 Pancreatic trypsin inhibitor Bos taurus 76.8 77.99 yes 104.0 Sodium acetate-Acetic acid 10 mM DSC Thermal 4.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 7507751 10.1002/pro.5560021204 1993 ProTherm 18300 76 100 Pancreatic trypsin inhibitor Bos taurus 74.6 77.5 yes 104.5 Sodium acetate-Acetic acid 10 mM DSC Thermal 4.9 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 7507751 10.1002/pro.5560021204 1993 ProTherm 18354 76 100 Pancreatic trypsin inhibitor Bos taurus 51.0 yes 72.6 citrate 5 mM CD Thermal 4.6 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 7683491 10.1021/bi00068a012 1993 ProTherm 19459 76 100 Pancreatic trypsin inhibitor Bos taurus 2.97 145.08 yes 65.7 MES-NaOH 30 mM Absorbance Thermal 5.8 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 7519988 10.1111/j.1432-1033.1994.tb19071.x 1994 ProTherm 19706 76 100 Pancreatic trypsin inhibitor Bos taurus yes 38.0 acetate 20 mM CD Thermal 4.7 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 10772865 10.1006/jmbi.2000.3622 2000 ProTherm 19707 76 100 Pancreatic trypsin inhibitor Bos taurus yes 39.0 acetate 20 mM CD Thermal 4.7 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 10772865 10.1006/jmbi.2000.3622 2000 ProTherm 19708 76 100 Pancreatic trypsin inhibitor Bos taurus yes 20.0 acetate 20 mM CD Thermal 4.7 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 10772865 10.1006/jmbi.2000.3622 2000 ProTherm 20340 76 100 Pancreatic trypsin inhibitor Bos taurus 6.6 Unknown HCl 30.0 NMR Urea 3.5 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 7690588 10.1021/bi00088a013 1993 ProTherm 20524 76 100 Pancreatic trypsin inhibitor Bos taurus 0.7 9.0 Unknown glycine-HCl 10 mM 25.0 NaCl 0.1 M DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 7690587 10.1021/bi00088a012 1993 ProTherm 20645 76 100 Pancreatic trypsin inhibitor Bos taurus 9.0 Unknown glycine-HCl 10 mM 25.0 NaCl 0.1 N DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 7686069 10.1002/pro.5560020410 1993 ProTherm 20723 76 100 Pancreatic trypsin inhibitor Bos taurus yes Tris-HCl 0.1 M 25.0 KCl 0.2 M HPLC GSSG, GSH 8.7 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 7681323 10.1021/bi00062a015 1993 ProTherm 20767 76 100 Pancreatic trypsin inhibitor Bos taurus 11.8 no Potassium phosphate 1 mM 25.0 NaCl 0.1 M DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 2443162 10.1021/bi00386a044 1987 ProTherm 20768 76 100 Pancreatic trypsin inhibitor Bos taurus 14.3 no Potassium phosphate 1 mM 25.0 NaCl 0.1 M DSC Thermal 5.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 2443162 10.1021/bi00386a044 1987 ProTherm 2943 1553 100 R36A Pancreatic trypsin inhibitor Bos taurus 41.0 -3.9 Unknown 35.3 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 3.0 1BPI 17.62363624572754 7540212 10.1006/jmbi.1995.0304 1995 ProTherm AUTOMUTE_S1962.csv, Broom_S605.csv, EASE-MM_S543.csv, HotMuSiC_S1626.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8162 1553 100 R36A Pancreatic trypsin inhibitor Bos taurus 0.5 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 3.0 1BPI 17.62363624572754 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 2944 1554 100 P37A Pancreatic trypsin inhibitor Bos taurus 37.0 -9.8 Unknown 29.4 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 15.695714133126396 7540212 10.1006/jmbi.1995.0304 1995 ProTherm AUTOMUTE_S1962.csv, Broom_S605.csv, EASE-MM_S543.csv, HotMuSiC_S1626.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8163 1554 100 P37A Pancreatic trypsin inhibitor Bos taurus 1.3 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 15.695714133126396 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 2945 1555 100 D38A Pancreatic trypsin inhibitor Bos taurus 44.0 1.4 Unknown 40.6 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 4.0 1BPI 19.335000097751617 7540212 10.1006/jmbi.1995.0304 1995 ProTherm AUTOMUTE_S1962.csv, EASE-MM_S543.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv, Broom_S605.csv, HotMuSiC_S1626.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8164 1555 100 D38A Pancreatic trypsin inhibitor Bos taurus -0.2 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 4.0 1BPI 19.335000097751617 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 2946 1556 100 F39A Pancreatic trypsin inhibitor Bos taurus -21.0 Unknown 18.0 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 4.0 1BPI 11.619090990586715 7540212 10.1006/jmbi.1995.0304 1995 ProTherm AUTOMUTE_S1962.csv, EASE-MM_S543.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv, HotMuSiC_S1626.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8165 1556 100 F39A Pancreatic trypsin inhibitor Bos taurus 3.0 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 4.0 1BPI 11.619090990586715 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 11321 4816 100 F39L Pancreatic trypsin inhibitor Bos taurus 2.2 yes Tris-HCl 0.1 M 25.0 KCl 0.2 M Gel electrophoresis Urea 8.7 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 4.0 1BPI 11.619090990586715 9232657 10.1002/pro.5560060720 1997 ProTherm 749 456 100 L41M Pancreatic trypsin inhibitor Bos taurus 77.3 78.1 yes 99.3 acetate/Na 10 mM DSC Thermal 4.3 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 3.0 1BPI 9.81124997138977 11910035 10.1110/ps.4460102 2002 ProTherm 8850 456 100 L41M Pancreatic trypsin inhibitor Bos taurus 12.4 yes GlyGly/HCl 10 mM 25.0 DSC Thermal 4.3 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 3.0 1BPI 9.81124997138977 11910035 10.1110/ps.4460102 2002 ProTherm 2947 1557 100 L41A Pancreatic trypsin inhibitor Bos taurus 40.0 -4.6 Unknown 34.6 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 3.0 1BPI 9.81124997138977 7540212 10.1006/jmbi.1995.0304 1995 ProTherm AUTOMUTE_S1962.csv, Broom_S605.csv, EASE-MM_S543.csv, HotMuSiC_S1626.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8166 1557 100 L41A Pancreatic trypsin inhibitor Bos taurus 0.6 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 3.0 1BPI 9.81124997138977 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 2948 1558 100 E42A Pancreatic trypsin inhibitor Bos taurus 42.0 -11.2 Unknown 28.0 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 6.0 1BPI 12.68111096488105 in pocket 7540212 10.1006/jmbi.1995.0304 1995 ProTherm AUTOMUTE_S1962.csv, EASE-MM_S543.csv, HotMuSiC_S1626.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv, Broom_S605.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8167 1558 100 E42A Pancreatic trypsin inhibitor Bos taurus 1.5 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 6.0 1BPI 12.68111096488105 in pocket 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 2949 1559 100 P43A Pancreatic trypsin inhibitor Bos taurus 40.0 -2.5 Unknown 36.7 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 6.0 1BPI 8.315714154924665 in pocket 7540212 10.1006/jmbi.1995.0304 1995 ProTherm AUTOMUTE_S1962.csv, Broom_S605.csv, EASE-MM_S543.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv, HotMuSiC_S1626.csv, Saraboji_S2204.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8168 1559 100 P43A Pancreatic trypsin inhibitor Bos taurus 0.3 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 6.0 1BPI 8.315714154924665 in pocket 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 2950 1560 100 P44A Pancreatic trypsin inhibitor Bos taurus 42.0 -5.5 Unknown 33.7 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 2.0 1BPI 6.23571423121861 in pocket 7540212 10.1006/jmbi.1995.0304 1995 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, Broom_S605.csv, HotMuSiC_S1626.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8169 1560 100 P44A Pancreatic trypsin inhibitor Bos taurus 0.8 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 2.0 1BPI 6.23571423121861 in pocket 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 2951 1561 100 Y45A Pancreatic trypsin inhibitor Bos taurus 32.0 -9.0 Unknown 30.2 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 4.0 1BPI 6.699166735013326 in pocket 7540212 10.1006/jmbi.1995.0304 1995 ProTherm AUTOMUTE_S1962.csv, Broom_S605.csv, HotMuSiC_S1626.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, EASE-MM_S1676.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8170 1561 100 Y45A Pancreatic trypsin inhibitor Bos taurus 1.2 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 4.0 1BPI 6.699166735013326 in pocket 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 11322 4817 100 Y45L Pancreatic trypsin inhibitor Bos taurus 2.9 yes Tris-HCl 0.1 M 25.0 KCl 0.2 M Gel electrophoresis Urea 8.7 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 4.0 1BPI 6.699166735013326 in pocket 9232657 10.1002/pro.5560060720 1997 ProTherm 750 457 100 T46M Pancreatic trypsin inhibitor Bos taurus 76.1 79.3 yes 97.9 acetate/Na 10 mM DSC Thermal 4.3 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 4.0 1BPI 4.46857145854405 11910035 10.1110/ps.4460102 2002 ProTherm 8851 457 100 T46M Pancreatic trypsin inhibitor Bos taurus 13.1 yes GlyGly/HCl 10 mM 25.0 DSC Thermal 4.3 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 4.0 1BPI 4.46857145854405 11910035 10.1110/ps.4460102 2002 ProTherm 2952 1562 100 T46A Pancreatic trypsin inhibitor Bos taurus 42.0 -0.2 Unknown 39.0 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 4.0 1BPI 4.46857145854405 7540212 10.1006/jmbi.1995.0304 1995 ProTherm AUTOMUTE_S1962.csv, capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv, Saraboji_S2204.csv, AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3563 1562 100 T46A Pancreatic trypsin inhibitor Bos taurus -0.3 yes 93.9 NaH2PO4 10 mM CD Thermal 3.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 4.0 1BPI 4.46857145854405 8784199 10.1021/bi960515w 1996 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8171 1562 100 T46A Pancreatic trypsin inhibitor Bos taurus 0.0 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 4.0 1BPI 4.46857145854405 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 2953 1563 100 G47A Pancreatic trypsin inhibitor Bos taurus 34.0 -13.1 Unknown 26.1 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0 1BPI 6.229999899864197 7540212 10.1006/jmbi.1995.0304 1995 ProTherm AUTOMUTE_S1962.csv, Broom_S605.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3556 1563 100 G47A Pancreatic trypsin inhibitor Bos taurus -16.1 yes 78.1 NaH2PO4 10 mM CD Thermal 3.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0 1BPI 6.229999899864197 8784199 10.1021/bi960515w 1996 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8172 1563 100 G47A Pancreatic trypsin inhibitor Bos taurus 1.8 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0 1BPI 6.229999899864197 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 10548 4459 100 G47D Pancreatic trypsin inhibitor Bos taurus 4.3 yes Tris-HCl 0.1 M 25.0 KCl 0.2 M HPLC GSSG, GSH 8.7 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0 1BPI 6.229999899864197 7681323 10.1021/bi00062a015 1993 ProTherm SAAFEC_S1262.csv 10549 4460 100 G47V Pancreatic trypsin inhibitor Bos taurus 4.1 yes Tris-HCl 0.1 M 25.0 KCl 0.2 M HPLC GSSG, GSH 8.7 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0 1BPI 6.229999899864197 7681323 10.1021/bi00062a015 1993 ProTherm SAAFEC_S1262.csv 2954 1564 100 P48A Pancreatic trypsin inhibitor Bos taurus 36.0 -9.0 Unknown 30.2 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 4.0 1BPI 7.6371427944728305 7540212 10.1006/jmbi.1995.0304 1995 ProTherm AUTOMUTE_S1962.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, Broom_S605.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3564 1564 100 P48A Pancreatic trypsin inhibitor Bos taurus 0.0 yes 94.2 NaH2PO4 10 mM CD Thermal 3.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 4.0 1BPI 7.6371427944728305 8784199 10.1021/bi960515w 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8173 1564 100 P48A Pancreatic trypsin inhibitor Bos taurus 1.2 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 4.0 1BPI 7.6371427944728305 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 10550 1564 100 P48A Pancreatic trypsin inhibitor Bos taurus 1.6 yes Tris-HCl 0.1 M 25.0 KCl 0.2 M HPLC GSSG, GSH 8.7 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 4.0 1BPI 7.6371427944728305 7681323 10.1021/bi00062a015 1993 ProTherm SAAFEC_S1262.csv 10551 4461 100 P48S Pancreatic trypsin inhibitor Bos taurus 1.4 yes Tris-HCl 0.1 M 25.0 KCl 0.2 M HPLC GSSG, GSH 8.7 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 4.0 1BPI 7.6371427944728305 7681323 10.1021/bi00062a015 1993 ProTherm SAAFEC_S1262.csv 14807 6949 100 C49A, C65A, C73A, C86A, M87L Pancreatic trypsin inhibitor Bos taurus yes 40.0 acetate 20 mM CD Thermal 4.7 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0, 9.0, 9.0, 9.0, 5.0 1BPI 6.463333288828532, 5.143333355585734, 5.973333438237508, 4.758333444595337, 7.647499978542328 10772865 10.1006/jmbi.2000.3622 2000 ProTherm 15304 7095 100 C49A, C73A Pancreatic trypsin inhibitor Bos taurus 5.38 6.9 1.28 yes Potassium phosphate 10 mM 25.0 Absorbance GdnHCl 7.8 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0, 9.0 1BPI 6.463333288828532, 5.973333438237508 1693524 10.1021/bi00470a021 1990 ProTherm 87 68 100 K50W Pancreatic trypsin inhibitor Bos taurus 0.22 65.12 65.84 yes 75.6 glycine-HCl 10 mM DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 88 68 100 K50W Pancreatic trypsin inhibitor Bos taurus 0.43 66.0 69.0 yes 78.8 glycine-HCl 10 mM DSC Thermal 2.5 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 135 68 100 K50W Pancreatic trypsin inhibitor Bos taurus 40.4 yes 54.4 glycine-HCl 10 mM CD Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 89 69 100 K50I Pancreatic trypsin inhibitor Bos taurus 0.36 65.12 67.61 yes 76.5 glycine-HCl 10 mM DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 90 69 100 K50I Pancreatic trypsin inhibitor Bos taurus 0.37 67.49 69.28 yes 79.8 glycine-HCl 10 mM DSC Thermal 2.5 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 91 69 100 K50I Pancreatic trypsin inhibitor Bos taurus 0.43 68.54 70.23 yes 85.6 glycine-HCl 10 mM DSC Thermal 3.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 92 70 100 K50F Pancreatic trypsin inhibitor Bos taurus 0.24 65.24 67.61 yes 77.2 glycine-HCl 10 mM DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 93 70 100 K50F Pancreatic trypsin inhibitor Bos taurus 0.55 66.24 67.61 yes 80.2 glycine-HCl 10 mM DSC Thermal 2.5 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 94 70 100 K50F Pancreatic trypsin inhibitor Bos taurus 0.43 68.8 74.3 yes 85.8 glycine-HCl 10 mM DSC Thermal 3.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 139 70 100 K50F Pancreatic trypsin inhibitor Bos taurus 41.7 yes 56.3 glycine-HCl 10 mM CD Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 95 71 100 K50Y Pancreatic trypsin inhibitor Bos taurus 0.4 65.9 64.32 yes 77.3 glycine-HCl 10 mM DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 96 71 100 K50Y Pancreatic trypsin inhibitor Bos taurus 0.36 67.2 66.2 yes 80.5 glycine-HCl 10 mM DSC Thermal 2.5 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 97 71 100 K50Y Pancreatic trypsin inhibitor Bos taurus 0.4 70.06 69.3 yes 85.1 glycine-HCl 10 mM DSC Thermal 3.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 98 72 100 K50L Pancreatic trypsin inhibitor Bos taurus 0.33 66.4 63.3 yes 77.7 glycine-HCl 10 mM DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 99 72 100 K50L Pancreatic trypsin inhibitor Bos taurus 0.25 67.9 69.0 yes 81.7 glycine-HCl 10 mM DSC Thermal 2.5 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 100 72 100 K50L Pancreatic trypsin inhibitor Bos taurus 0.27 69.52 73.1 yes 87.0 glycine-HCl 10 mM DSC Thermal 3.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 101 73 100 K50V Pancreatic trypsin inhibitor Bos taurus 0.29 66.91 68.56 yes 77.9 glycine-HCl 10 mM DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 102 73 100 K50V Pancreatic trypsin inhibitor Bos taurus 0.57 68.2 70.71 yes 80.3 glycine-HCl 10 mM DSC Thermal 2.5 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 103 73 100 K50V Pancreatic trypsin inhibitor Bos taurus 0.41 70.02 73.58 yes 85.4 glycine-HCl 10 mM DSC Thermal 3.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 104 74 100 K50M Pancreatic trypsin inhibitor Bos taurus 0.4 66.0 63.8 yes 78.8 glycine-HCl 10 mM DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm PON-TStab_dataset.csv 105 74 100 K50M Pancreatic trypsin inhibitor Bos taurus 0.31 67.9 70.7 yes 80.0 glycine-HCl 10 mM DSC Thermal 2.5 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 106 74 100 K50M Pancreatic trypsin inhibitor Bos taurus 0.32 70.0 69.9 yes 86.8 glycine-HCl 10 mM DSC Thermal 3.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm HotMuSiC_S1626.csv 141 74 100 K50M Pancreatic trypsin inhibitor Bos taurus 45.1 yes 58.8 glycine-HCl 10 mM CD Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv 107 75 100 K50E Pancreatic trypsin inhibitor Bos taurus 0.2 71.7 79.1 yes 77.2 glycine-HCl 10 mM DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 108 76 100 K50Q Pancreatic trypsin inhibitor Bos taurus 0.32 66.5 65.2 yes 79.5 glycine-HCl 10 mM DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm HotMuSiC_S1626.csv 109 76 100 K50Q Pancreatic trypsin inhibitor Bos taurus 0.23 68.1 68.7 yes 82.8 glycine-HCl 10 mM DSC Thermal 2.5 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm HotMuSiC_S1626.csv 110 76 100 K50Q Pancreatic trypsin inhibitor Bos taurus 0.36 70.2 67.0 yes 88.2 glycine-HCl 10 mM DSC Thermal 3.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 111 77 100 K50A Pancreatic trypsin inhibitor Bos taurus 0.42 67.3 66.3 yes 79.6 glycine-HCl 10 mM DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 2955 77 100 K50A Pancreatic trypsin inhibitor Bos taurus 37.0 -2.6 Unknown 36.6 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 7540212 10.1006/jmbi.1995.0304 1995 ProTherm PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv, HotMuSiC_S1626.csv, M47andM8_S2760.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3560 77 100 K50A Pancreatic trypsin inhibitor Bos taurus -4.2 yes 90.0 NaH2PO4 10 mM CD Thermal 3.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 8784199 10.1021/bi960515w 1996 ProTherm Broom_S605.csv, PoPMuSiC-2.0_S2648.csv, AUTOMUTE_S1749.csv, HotMuSiC_S1626.csv, Saraboji_S1791.csv 8174 77 100 K50A Pancreatic trypsin inhibitor Bos taurus 0.4 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 112 78 100 K50T Pancreatic trypsin inhibitor Bos taurus 0.24 67.5 70.4 yes 80.8 glycine-HCl 10 mM DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 113 78 100 K50T Pancreatic trypsin inhibitor Bos taurus 0.3 68.7 66.0 yes 84.4 glycine-HCl 10 mM DSC Thermal 2.5 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 114 78 100 K50T Pancreatic trypsin inhibitor Bos taurus 0.26 73.2 73.3 yes 90.6 glycine-HCl 10 mM DSC Thermal 3.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 142 78 100 K50T Pancreatic trypsin inhibitor Bos taurus 44.3 yes 60.1 glycine-HCl 10 mM CD Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 6462 78 100 K50T Pancreatic trypsin inhibitor Bos taurus 0.29 yes glycine-HCl 10 mM 89.0 DSC Thermal 3.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 6480 78 100 K50T Pancreatic trypsin inhibitor Bos taurus 0.23 yes glycine-HCl 10 mM 83.0 DSC Thermal 2.5 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 115 79 100 K50S Pancreatic trypsin inhibitor Bos taurus 0.45 68.49 69.71 yes 81.4 glycine-HCl 10 mM DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 116 79 100 K50S Pancreatic trypsin inhibitor Bos taurus 0.43 68.99 70.0 yes 84.6 glycine-HCl 10 mM DSC Thermal 2.5 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 117 79 100 K50S Pancreatic trypsin inhibitor Bos taurus 0.41 72.15 76.45 yes 90.4 glycine-HCl 10 mM DSC Thermal 3.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 6463 79 100 K50S Pancreatic trypsin inhibitor Bos taurus 0.27 yes glycine-HCl 10 mM 89.0 DSC Thermal 3.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 6481 79 100 K50S Pancreatic trypsin inhibitor Bos taurus 0.29 yes glycine-HCl 10 mM 83.0 DSC Thermal 2.5 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 6512 79 100 K50S Pancreatic trypsin inhibitor Bos taurus 0.08 yes glycine-HCl 10 mM 81.0 DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 118 80 100 K50G Pancreatic trypsin inhibitor Bos taurus 0.24 67.75 68.25 yes 81.5 glycine-HCl 10 mM DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 119 80 100 K50G Pancreatic trypsin inhibitor Bos taurus 0.29 68.25 68.56 yes 84.7 glycine-HCl 10 mM DSC Thermal 2.5 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 120 80 100 K50G Pancreatic trypsin inhibitor Bos taurus 0.19 70.95 72.15 yes 89.8 glycine-HCl 10 mM DSC Thermal 3.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 6464 80 100 K50G Pancreatic trypsin inhibitor Bos taurus 0.13 yes glycine-HCl 10 mM 89.0 DSC Thermal 3.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 6482 80 100 K50G Pancreatic trypsin inhibitor Bos taurus 0.3 yes glycine-HCl 10 mM 83.0 DSC Thermal 2.5 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 6513 80 100 K50G Pancreatic trypsin inhibitor Bos taurus 0.09 yes glycine-HCl 10 mM 81.0 DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 121 81 100 K50D Pancreatic trypsin inhibitor Bos taurus 0.33 67.85 70.71 yes 82.0 glycine-HCl 10 mM DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 122 81 100 K50D Pancreatic trypsin inhibitor Bos taurus 0.28 70.2 76.0 yes 84.4 glycine-HCl 10 mM DSC Thermal 2.5 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm M47andM8_S1810.csv, M47andM8_S2760.csv, Saraboji_S1396.csv 123 81 100 K50D Pancreatic trypsin inhibitor Bos taurus 0.36 71.2 76.0 yes 89.4 glycine-HCl 10 mM DSC Thermal 3.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm EASE-MM_S1676.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S1396.csv 138 81 100 K50D Pancreatic trypsin inhibitor Bos taurus 46.5 yes 61.4 glycine-HCl 10 mM CD Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 6465 81 100 K50D Pancreatic trypsin inhibitor Bos taurus 0.06 yes glycine-HCl 10 mM 89.0 DSC Thermal 3.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 6483 81 100 K50D Pancreatic trypsin inhibitor Bos taurus 0.27 yes glycine-HCl 10 mM 83.0 DSC Thermal 2.5 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 6514 81 100 K50D Pancreatic trypsin inhibitor Bos taurus 0.19 yes glycine-HCl 10 mM 81.0 DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 124 82 100 K50N Pancreatic trypsin inhibitor Bos taurus 0.36 67.99 70.47 yes 82.3 glycine-HCl 10 mM DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 125 82 100 K50N Pancreatic trypsin inhibitor Bos taurus 0.43 69.52 72.38 yes 84.9 glycine-HCl 10 mM DSC Thermal 2.5 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 6484 82 100 K50N Pancreatic trypsin inhibitor Bos taurus 0.36 yes glycine-HCl 10 mM 83.0 DSC Thermal 2.5 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 6515 82 100 K50N Pancreatic trypsin inhibitor Bos taurus 0.25 yes glycine-HCl 10 mM 81.0 DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 129 84 100 K50R Pancreatic trypsin inhibitor Bos taurus 0.31 68.44 67.85 yes 83.6 glycine-HCl 10 mM DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 130 84 100 K50R Pancreatic trypsin inhibitor Bos taurus 0.41 70.47 73.58 yes 87.3 glycine-HCl 10 mM DSC Thermal 2.5 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 131 84 100 K50R Pancreatic trypsin inhibitor Bos taurus 0.33 72.29 76.21 yes 93.3 glycine-HCl 10 mM DSC Thermal 3.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 137 84 100 K50R Pancreatic trypsin inhibitor Bos taurus 44.3 yes 59.2 glycine-HCl 10 mM CD Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 6467 84 100 K50R Pancreatic trypsin inhibitor Bos taurus 0.87 yes glycine-HCl 10 mM 89.0 DSC Thermal 3.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 6486 84 100 K50R Pancreatic trypsin inhibitor Bos taurus 0.85 yes glycine-HCl 10 mM 83.0 DSC Thermal 2.5 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 6517 84 100 K50R Pancreatic trypsin inhibitor Bos taurus 0.45 yes glycine-HCl 10 mM 81.0 DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 132 85 100 K50H Pancreatic trypsin inhibitor Bos taurus 0.33 69.9 69.28 yes 86.7 glycine-HCl 10 mM DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 133 85 100 K50H Pancreatic trypsin inhibitor Bos taurus 0.29 71.74 74.3 yes 90.4 glycine-HCl 10 mM DSC Thermal 2.5 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 134 85 100 K50H Pancreatic trypsin inhibitor Bos taurus 0.33 73.27 75.49 yes 95.5 glycine-HCl 10 mM DSC Thermal 3.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 136 85 100 K50H Pancreatic trypsin inhibitor Bos taurus 41.0 yes 61.5 glycine-HCl 10 mM CD Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 6468 85 100 K50H Pancreatic trypsin inhibitor Bos taurus 1.3 yes glycine-HCl 10 mM 89.0 DSC Thermal 3.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 6487 85 100 K50H Pancreatic trypsin inhibitor Bos taurus 1.48 yes glycine-HCl 10 mM 83.0 DSC Thermal 2.5 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 6518 85 100 K50H Pancreatic trypsin inhibitor Bos taurus 1.09 yes glycine-HCl 10 mM 81.0 DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 18.9155560069614 11274462 10.1110/ps.38101 2001 ProTherm 10552 4462 100 A51T Pancreatic trypsin inhibitor Bos taurus 1.7 yes Tris-HCl 0.1 M 25.0 KCl 0.2 M HPLC GSSG, GSH 8.7 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 8.0 1BPI 5.415999984741211 7681323 10.1021/bi00062a015 1993 ProTherm SAAFEC_S1262.csv 10553 4463 100 A51V Pancreatic trypsin inhibitor Bos taurus 1.3 yes Tris-HCl 0.1 M 25.0 KCl 0.2 M HPLC GSSG, GSH 8.7 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 8.0 1BPI 5.415999984741211 7681323 10.1021/bi00062a015 1993 ProTherm SAAFEC_S1262.csv 2956 1565 100 R52A Pancreatic trypsin inhibitor Bos taurus 41.0 -1.9 Unknown 37.3 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 1.0 1BPI 6.841818245974454 7540212 10.1006/jmbi.1995.0304 1995 ProTherm M47andM8_S2760.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3561 1565 100 R52A Pancreatic trypsin inhibitor Bos taurus -4.7 yes 89.5 NaH2PO4 10 mM CD Thermal 3.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 1.0 1BPI 6.841818245974454 8784199 10.1021/bi960515w 1996 ProTherm Saraboji_S2204.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8175 1565 100 R52A Pancreatic trypsin inhibitor Bos taurus 0.3 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 1.0 1BPI 6.841818245974454 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 2957 1566 100 I53A Pancreatic trypsin inhibitor Bos taurus 33.0 -10.9 Unknown 28.3 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 4.0 1BPI 5.328750014305115 7540212 10.1006/jmbi.1995.0304 1995 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, EASE-MM_S1676.csv, Broom_S605.csv, AUTOMUTE_S1749.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S1791.csv, STRUM_Q3421.csv 3554 1566 100 I53A Pancreatic trypsin inhibitor Bos taurus 0.2 yes 94.4 NaH2PO4 10 mM CD Thermal 3.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 4.0 1BPI 5.328750014305115 8784199 10.1021/bi960515w 1996 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8176 1566 100 I53A Pancreatic trypsin inhibitor Bos taurus 1.5 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 4.0 1BPI 5.328750014305115 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 2958 1567 100 I54A Pancreatic trypsin inhibitor Bos taurus 35.0 -15.1 Unknown 24.1 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 3.0 1BPI 7.347500026226044 7540212 10.1006/jmbi.1995.0304 1995 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, Broom_S605.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv, STRUM_Q3421.csv 3562 1567 100 I54A Pancreatic trypsin inhibitor Bos taurus -4.8 yes 89.4 NaH2PO4 10 mM CD Thermal 3.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 3.0 1BPI 7.347500026226044 8784199 10.1021/bi960515w 1996 ProTherm PoPMuSiC-2.0_S2648.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8177 1567 100 I54A Pancreatic trypsin inhibitor Bos taurus 2.1 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 3.0 1BPI 7.347500026226044 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 2959 1568 100 R55A Pancreatic trypsin inhibitor Bos taurus 38.0 -13.2 Unknown 26.0 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 7.0 1BPI 4.503636360168457 7540212 10.1006/jmbi.1995.0304 1995 ProTherm M47andM8_S2760.csv, M47andM8_S1810.csv, AUTOMUTE_S1749.csv, EASE-MM_S1676.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S1791.csv, STRUM_Q3421.csv 3565 1568 100 R55A Pancreatic trypsin inhibitor Bos taurus 0.0 yes 94.2 NaH2PO4 10 mM CD Thermal 3.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 7.0 1BPI 4.503636360168457 8784199 10.1021/bi960515w 1996 ProTherm Broom_S605.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8178 1568 100 R55A Pancreatic trypsin inhibitor Bos taurus 1.8 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 7.0 1BPI 4.503636360168457 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 11323 4818 100 Y56L Pancreatic trypsin inhibitor Bos taurus 3.4 yes Tris-HCl 0.1 M 25.0 KCl 0.2 M Gel electrophoresis Urea 8.7 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 7.0 1BPI 4.456666688124339 9232657 10.1002/pro.5560060720 1997 ProTherm 12785 5934 100 Y56A Pancreatic trypsin inhibitor Bos taurus 5.86 3.9 5.1 0.88 yes (>90%) glycine 20 mM 20.0 CD GdnHCl 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 7.0 1BPI 4.456666688124339 11841216 10.1021/bi0116947 2002 ProTherm SAAFEC_S1262.csv 751 458 100 F57M Pancreatic trypsin inhibitor Bos taurus 68.4 68.6 yes 84.0 acetate/Na 10 mM DSC Thermal 4.3 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 6.0 1BPI 4.535454598340121 11910035 10.1110/ps.4460102 2002 ProTherm 8852 458 100 F57M Pancreatic trypsin inhibitor Bos taurus 8.8 yes GlyGly/HCl 10 mM 25.0 DSC Thermal 4.3 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 6.0 1BPI 4.535454598340121 11910035 10.1110/ps.4460102 2002 ProTherm 1506 873 100 F57A Pancreatic trypsin inhibitor Bos taurus 68.0 -9.0 Unknown 78.0 glycine-HCl 10 mM NaCl 0.1 N DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 6.0 1BPI 4.535454598340121 7686069 10.1002/pro.5560020410 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 2960 873 100 F57A Pancreatic trypsin inhibitor Bos taurus 37.0 -14.7 Unknown 24.5 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 6.0 1BPI 4.535454598340121 7540212 10.1006/jmbi.1995.0304 1995 ProTherm AUTOMUTE_S1962.csv, Broom_S605.csv, Saraboji_S2204.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8179 873 100 F57A Pancreatic trypsin inhibitor Bos taurus 2.0 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 6.0 1BPI 4.535454598340121 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, potapov_with_uniprot_mapping.csv 9239 873 100 F57A Pancreatic trypsin inhibitor Bos taurus 1.2 7.8 Unknown glycine-HCl 10 mM 25.0 NaCl 0.1 N DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 6.0 1BPI 4.535454598340121 7686069 10.1002/pro.5560020410 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 12786 873 100 F57A Pancreatic trypsin inhibitor Bos taurus 8.19 1.0 8.0 0.97 yes (>90%) glycine 20 mM 20.0 CD GdnHCl 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 6.0 1BPI 4.535454598340121 11841216 10.1021/bi0116947 2002 ProTherm 11324 4819 100 F57L Pancreatic trypsin inhibitor Bos taurus 5.6 yes Tris-HCl 0.1 M 25.0 KCl 0.2 M Gel electrophoresis Urea 8.7 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 6.0 1BPI 4.535454598340121 9232657 10.1002/pro.5560060720 1997 ProTherm 1507 874 100 Y58A Pancreatic trypsin inhibitor Bos taurus 45.0 -33.0 Unknown 54.0 glycine-HCl 10 mM NaCl 0.1 N DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 8.0 1BPI 5.35833336909612 7686069 10.1002/pro.5560020410 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 9240 874 100 Y58A Pancreatic trypsin inhibitor Bos taurus 5.9 3.1 Unknown glycine-HCl 10 mM 25.0 NaCl 0.1 N DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 8.0 1BPI 5.35833336909612 7686069 10.1002/pro.5560020410 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 12787 874 100 Y58A Pancreatic trypsin inhibitor Bos taurus 3.53 6.0 3.0 0.85 yes (>90%) glycine 20 mM 20.0 CD GdnHCl 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 8.0 1BPI 5.35833336909612 11841216 10.1021/bi0116947 2002 ProTherm SAAFEC_S1262.csv 11325 4820 100 Y58L Pancreatic trypsin inhibitor Bos taurus 7.1 yes Tris-HCl 0.1 M 25.0 KCl 0.2 M Gel electrophoresis Urea 8.7 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 8.0 1BPI 5.35833336909612 9232657 10.1002/pro.5560060720 1997 ProTherm 2961 1569 100 N59A Pancreatic trypsin inhibitor Bos taurus 40.0 -15.8 Unknown 23.4 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 8.0 1BPI 5.075000017881393 7540212 10.1006/jmbi.1995.0304 1995 ProTherm AUTOMUTE_S1962.csv, Broom_S605.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8180 1569 100 N59A Pancreatic trypsin inhibitor Bos taurus 2.2 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 8.0 1BPI 5.075000017881393 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 2962 1570 100 K61A Pancreatic trypsin inhibitor Bos taurus 44.0 -0.1 Unknown 39.1 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 3.0 1BPI 6.95888884862264 7540212 10.1006/jmbi.1995.0304 1995 ProTherm AUTOMUTE_S1962.csv, capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv, Saraboji_S2204.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8181 1570 100 K61A Pancreatic trypsin inhibitor Bos taurus 0.0 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 3.0 1BPI 6.95888884862264 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 2963 1571 100 G63A Pancreatic trypsin inhibitor Bos taurus 43.0 -7.3 Unknown 31.9 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 4.0 1BPI 5.412500023841858 7540212 10.1006/jmbi.1995.0304 1995 ProTherm Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1962.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8182 1571 100 G63A Pancreatic trypsin inhibitor Bos taurus 1.0 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 4.0 1BPI 5.412500023841858 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 752 459 100 L64M Pancreatic trypsin inhibitor Bos taurus 78.9 80.0 yes 100.8 acetate/Na 10 mM DSC Thermal 4.3 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 3.0 1BPI 5.892500013113022 11910035 10.1110/ps.4460102 2002 ProTherm HotMuSiC_S1626.csv 8853 459 100 L64M Pancreatic trypsin inhibitor Bos taurus 13.3 yes GlyGly/HCl 10 mM 25.0 DSC Thermal 4.3 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 3.0 1BPI 5.892500013113022 11910035 10.1110/ps.4460102 2002 ProTherm 2964 1572 100 L64A Pancreatic trypsin inhibitor Bos taurus 42.0 0.3 Unknown 39.5 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 3.0 1BPI 5.892500013113022 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1962.csv, Broom_S605.csv, PoPMuSiC-2.0_S2648.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8183 1572 100 L64A Pancreatic trypsin inhibitor Bos taurus 0.0 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 3.0 1BPI 5.892500013113022 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14672 6843 100 C65A, C86A Pancreatic trypsin inhibitor Bos taurus 59.4 64.8 -33.0 no 71.0 Potassium phosphate 10 mM NaCl 0.1 M DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0, 9.0 1BPI 5.143333355585734, 4.758333444595337 9154914 10.1021/bi962423c 1997 ProTherm 14865 6843 100 C65A, C86A Pancreatic trypsin inhibitor Bos taurus 6.14 no Potassium phosphate 10 mM 105.0 NaCl 0.1 M DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0, 9.0 1BPI 5.143333355585734, 4.758333444595337 9154914 10.1021/bi962423c 1997 ProTherm 15604 6843 100 C65A, C86A Pancreatic trypsin inhibitor Bos taurus 4.99 6.0 1.2 yes Potassium phosphate 10 mM 15.0 Absorbance GdnHCl 7.8 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0, 9.0 1BPI 5.143333355585734, 4.758333444595337 1693524 10.1021/bi00470a021 1990 ProTherm 14673 6844 100 C65V, C86A Pancreatic trypsin inhibitor Bos taurus 59.5 58.9 -32.0 no 72.0 Potassium phosphate 10 mM NaCl 0.1 M DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0, 9.0 1BPI 5.143333355585734, 4.758333444595337 9154914 10.1021/bi962423c 1997 ProTherm 14866 6844 100 C65V, C86A Pancreatic trypsin inhibitor Bos taurus 5.95 no Potassium phosphate 10 mM 105.0 NaCl 0.1 M DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0, 9.0 1BPI 5.143333355585734, 4.758333444595337 9154914 10.1021/bi962423c 1997 ProTherm 15603 6844 100 C65V, C86A Pancreatic trypsin inhibitor Bos taurus 5.41 7.8 1.5 yes Potassium phosphate 10 mM 15.0 Absorbance GdnHCl 7.8 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0, 9.0 1BPI 5.143333355585734, 4.758333444595337 1693524 10.1021/bi00470a021 1990 ProTherm 14674 6845 100 C65G, C86A Pancreatic trypsin inhibitor Bos taurus 51.9 54.6 -47.0 no 57.0 Potassium phosphate 10 mM NaCl 0.1 M DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0, 9.0 1BPI 5.143333355585734, 4.758333444595337 9154914 10.1021/bi962423c 1997 ProTherm 14867 6845 100 C65G, C86A Pancreatic trypsin inhibitor Bos taurus 8.74 no Potassium phosphate 10 mM 105.0 NaCl 0.1 M DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0, 9.0 1BPI 5.143333355585734, 4.758333444595337 9154914 10.1021/bi962423c 1997 ProTherm 14675 6846 100 C65T, C86A Pancreatic trypsin inhibitor Bos taurus 52.4 53.9 -42.0 no 62.0 Potassium phosphate 10 mM NaCl 0.1 M DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0, 9.0 1BPI 5.143333355585734, 4.758333444595337 9154914 10.1021/bi962423c 1997 ProTherm 14868 6846 100 C65T, C86A Pancreatic trypsin inhibitor Bos taurus 7.81 no Potassium phosphate 10 mM 105.0 NaCl 0.1 M DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0, 9.0 1BPI 5.143333355585734, 4.758333444595337 9154914 10.1021/bi962423c 1997 ProTherm 15303 6846 100 C65T, C86A Pancreatic trypsin inhibitor Bos taurus 3.81 4.6 1.21 yes Potassium phosphate 10 mM 25.0 Absorbance GdnHCl 7.8 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0, 9.0 1BPI 5.143333355585734, 4.758333444595337 1693524 10.1021/bi00470a021 1990 ProTherm 14676 6847 100 C65S, C86A Pancreatic trypsin inhibitor Bos taurus 55.7 56.6 -43.0 no 61.0 Potassium phosphate 10 mM NaCl 0.1 M DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0, 9.0 1BPI 5.143333355585734, 4.758333444595337 9154914 10.1021/bi962423c 1997 ProTherm 14869 6847 100 C65S, C86A Pancreatic trypsin inhibitor Bos taurus 8.0 no Potassium phosphate 10 mM 105.0 NaCl 0.1 M DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0, 9.0 1BPI 5.143333355585734, 4.758333444595337 9154914 10.1021/bi962423c 1997 ProTherm 14677 6848 100 C65A, C86S Pancreatic trypsin inhibitor Bos taurus 50.4 57.5 -48.0 no 56.0 Potassium phosphate 10 mM NaCl 0.1 M DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0, 9.0 1BPI 5.143333355585734, 4.758333444595337 9154914 10.1021/bi962423c 1997 ProTherm 14870 6848 100 C65A, C86S Pancreatic trypsin inhibitor Bos taurus 8.93 no Potassium phosphate 10 mM 105.0 NaCl 0.1 M DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0, 9.0 1BPI 5.143333355585734, 4.758333444595337 9154914 10.1021/bi962423c 1997 ProTherm 2965 1573 100 Q66A Pancreatic trypsin inhibitor Bos taurus 39.0 -7.5 Unknown 31.7 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 5.97888888253106 7540212 10.1006/jmbi.1995.0304 1995 ProTherm AUTOMUTE_S1925.csv, AUTOMUTE_S1962.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, Broom_S605.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8184 1573 100 Q66A Pancreatic trypsin inhibitor Bos taurus 1.0 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 5.97888888253106 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 753 460 100 T67M Pancreatic trypsin inhibitor Bos taurus 64.8 67.5 yes 91.0 acetate/Na 10 mM DSC Thermal 4.3 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 3.0 1BPI 4.832857097898211 11910035 10.1110/ps.4460102 2002 ProTherm HotMuSiC_S1626.csv 8854 460 100 T67M Pancreatic trypsin inhibitor Bos taurus 9.3 yes GlyGly/HCl 10 mM 25.0 DSC Thermal 4.3 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 3.0 1BPI 4.832857097898211 11910035 10.1110/ps.4460102 2002 ProTherm 2966 1574 100 T67A Pancreatic trypsin inhibitor Bos taurus 40.0 -0.4 Unknown 38.8 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 3.0 1BPI 4.832857097898211 7540212 10.1006/jmbi.1995.0304 1995 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8185 1574 100 T67A Pancreatic trypsin inhibitor Bos taurus 0.1 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 3.0 1BPI 4.832857097898211 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3555 1842 100 F68A Pancreatic trypsin inhibitor Bos taurus -16.5 yes 77.7 NaH2PO4 10 mM CD Thermal 3.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0 1BPI 4.789090850136497 8784199 10.1021/bi960515w 1996 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 10554 4464 100 F68I Pancreatic trypsin inhibitor Bos taurus 2.4 yes Tris-HCl 0.1 M 25.0 KCl 0.2 M HPLC GSSG, GSH 8.7 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0 1BPI 4.789090850136497 7681323 10.1021/bi00062a015 1993 ProTherm SAAFEC_S1262.csv 10555 4465 100 F68L Pancreatic trypsin inhibitor Bos taurus 1.3 yes Tris-HCl 0.1 M 25.0 KCl 0.2 M HPLC GSSG, GSH 8.7 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0 1BPI 4.789090850136497 7681323 10.1021/bi00062a015 1993 ProTherm SAAFEC_S1262.csv 11326 4465 100 F68L Pancreatic trypsin inhibitor Bos taurus 4.1 yes Tris-HCl 0.1 M 25.0 KCl 0.2 M Gel electrophoresis Urea 8.7 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0 1BPI 4.789090850136497 9232657 10.1002/pro.5560060720 1997 ProTherm 2967 1575 100 V69A Pancreatic trypsin inhibitor Bos taurus 41.0 -9.0 Unknown 30.2 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 4.0 1BPI 6.002857106072562 7540212 10.1006/jmbi.1995.0304 1995 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3566 1575 100 V69A Pancreatic trypsin inhibitor Bos taurus 0.0 yes 94.2 NaH2PO4 10 mM CD Thermal 3.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 4.0 1BPI 6.002857106072562 8784199 10.1021/bi960515w 1996 ProTherm STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8186 1575 100 V69A Pancreatic trypsin inhibitor Bos taurus 1.2 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 4.0 1BPI 6.002857106072562 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1508 875 100 Y70G Pancreatic trypsin inhibitor Bos taurus 38.0 -18.0 Unknown 69.0 glycine-HCl 10 mM NaCl 0.1 N DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0 1BPI 5.239166657129924 7686069 10.1002/pro.5560020410 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 2984 875 100 Y70G Pancreatic trypsin inhibitor Bos taurus 38.0 -18.0 Unknown 69.0 glycine-HCl 10 mM NaCl 0.1 N DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0 1BPI 5.239166657129924 7690587 10.1021/bi00088a012 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8762 875 100 Y70G Pancreatic trypsin inhibitor Bos taurus 0.7 5.0 4.0 Unknown glycine-HCl 10 mM 25.0 NaCl 0.1 M DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0 1BPI 5.239166657129924 7690587 10.1021/bi00088a012 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 9241 875 100 Y70G Pancreatic trypsin inhibitor Bos taurus 5.0 4.0 Unknown glycine-HCl 10 mM 25.0 NaCl 0.1 N DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0 1BPI 5.239166657129924 7686069 10.1002/pro.5560020410 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 10559 875 100 Y70G Pancreatic trypsin inhibitor Bos taurus 5.0 yes Tris-HCl 0.1 M 25.0 KCl 0.2 M HPLC GSSG, GSH 8.7 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0 1BPI 5.239166657129924 7681323 10.1021/bi00062a015 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 2968 1576 100 Y70A Pancreatic trypsin inhibitor Bos taurus 29.0 -8.3 Unknown 30.9 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0 1BPI 5.239166657129924 7540212 10.1006/jmbi.1995.0304 1995 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, SVM-WIN31_SVM-3D12_S499.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3557 1576 100 Y70A Pancreatic trypsin inhibitor Bos taurus -16.2 yes 78.0 NaH2PO4 10 mM CD Thermal 3.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0 1BPI 5.239166657129924 8784199 10.1021/bi960515w 1996 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8187 1576 100 Y70A Pancreatic trypsin inhibitor Bos taurus 1.1 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0 1BPI 5.239166657129924 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 10556 1576 100 Y70A Pancreatic trypsin inhibitor Bos taurus 4.7 yes Tris-HCl 0.1 M 25.0 KCl 0.2 M HPLC GSSG, GSH 8.7 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0 1BPI 5.239166657129924 7681323 10.1021/bi00062a015 1993 ProTherm SAAFEC_S1262.csv 10557 4466 100 Y70D Pancreatic trypsin inhibitor Bos taurus 3.8 yes Tris-HCl 0.1 M 25.0 KCl 0.2 M HPLC GSSG, GSH 8.7 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0 1BPI 5.239166657129924 7681323 10.1021/bi00062a015 1993 ProTherm SAAFEC_S1262.csv 10558 4467 100 Y70F Pancreatic trypsin inhibitor Bos taurus 0.6 yes Tris-HCl 0.1 M 25.0 KCl 0.2 M HPLC GSSG, GSH 8.7 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0 1BPI 5.239166657129924 7681323 10.1021/bi00062a015 1993 ProTherm SAAFEC_S1262.csv 10560 4468 100 Y70L Pancreatic trypsin inhibitor Bos taurus 3.7 yes Tris-HCl 0.1 M 25.0 KCl 0.2 M HPLC GSSG, GSH 8.7 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0 1BPI 5.239166657129924 7681323 10.1021/bi00062a015 1993 ProTherm SAAFEC_S1262.csv 11327 4468 100 Y70L Pancreatic trypsin inhibitor Bos taurus 6.5 yes Tris-HCl 0.1 M 25.0 KCl 0.2 M Gel electrophoresis Urea 8.7 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0 1BPI 5.239166657129924 9232657 10.1002/pro.5560060720 1997 ProTherm 10561 4469 100 Y70N Pancreatic trypsin inhibitor Bos taurus 3.7 yes Tris-HCl 0.1 M 25.0 KCl 0.2 M HPLC GSSG, GSH 8.7 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0 1BPI 5.239166657129924 7681323 10.1021/bi00062a015 1993 ProTherm SAAFEC_S1262.csv 2969 1577 100 G71A Pancreatic trypsin inhibitor Bos taurus 31.0 -15.4 Unknown 23.8 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 8.0 1BPI 5.137500047683716 7540212 10.1006/jmbi.1995.0304 1995 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3559 1577 100 G71A Pancreatic trypsin inhibitor Bos taurus -11.7 yes 82.5 NaH2PO4 10 mM CD Thermal 3.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 8.0 1BPI 5.137500047683716 8784199 10.1021/bi960515w 1996 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8188 1577 100 G71A Pancreatic trypsin inhibitor Bos taurus 2.1 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 8.0 1BPI 5.137500047683716 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3078 1645 100 G71S Pancreatic trypsin inhibitor Bos taurus 51.0 -4.5 yes 67.9 citrate 5 mM CD Thermal 4.6 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 8.0 1BPI 5.137500047683716 7683491 10.1021/bi00068a012 1993 ProTherm AUTOMUTE_S1962.csv, STRUM_Q3421.csv, Saraboji_S2204.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6609 1645 100 G71S Pancreatic trypsin inhibitor Bos taurus 0.7 yes citrate 5 mM 72.6 CD Thermal 4.6 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 8.0 1BPI 5.137500047683716 7683491 10.1021/bi00068a012 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 10562 4470 100 G71D Pancreatic trypsin inhibitor Bos taurus 2.8 yes Tris-HCl 0.1 M 25.0 KCl 0.2 M HPLC GSSG, GSH 8.7 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 8.0 1BPI 5.137500047683716 7681323 10.1021/bi00062a015 1993 ProTherm SAAFEC_S1262.csv 2970 1578 100 G72A Pancreatic trypsin inhibitor Bos taurus 34.0 -17.2 Unknown 22.0 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0 1BPI 6.757499933242798 7540212 10.1006/jmbi.1995.0304 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 2985 1578 100 G72A Pancreatic trypsin inhibitor Bos taurus 47.0 -21.0 Unknown 66.0 glycine-HCl 10 mM NaCl 0.1 N DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0 1BPI 6.757499933242798 7690587 10.1021/bi00088a012 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3558 1578 100 G72A Pancreatic trypsin inhibitor Bos taurus -4.2 yes 90.0 NaH2PO4 10 mM CD Thermal 3.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0 1BPI 6.757499933242798 8784199 10.1021/bi960515w 1996 ProTherm AUTOMUTE_S1925.csv, AUTOMUTE_S1962.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8189 1578 100 G72A Pancreatic trypsin inhibitor Bos taurus 2.3 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0 1BPI 6.757499933242798 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 8763 1578 100 G72A Pancreatic trypsin inhibitor Bos taurus 0.7 4.9 4.1 Unknown glycine-HCl 10 mM 25.0 NaCl 0.1 M DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0 1BPI 6.757499933242798 7690587 10.1021/bi00088a012 1993 ProTherm capriotti_S1615_map.csv 10563 1578 100 G72A Pancreatic trypsin inhibitor Bos taurus 2.2 yes Tris-HCl 0.1 M 25.0 KCl 0.2 M HPLC GSSG, GSH 8.7 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0 1BPI 6.757499933242798 7681323 10.1021/bi00062a015 1993 ProTherm 12788 1578 100 G72A Pancreatic trypsin inhibitor Bos taurus 5.94 2.7 6.3 1.06 yes (>90%) glycine 20 mM 20.0 CD GdnHCl 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0 1BPI 6.757499933242798 11841216 10.1021/bi0116947 2002 ProTherm 10564 4471 100 G72D Pancreatic trypsin inhibitor Bos taurus 1.7 yes Tris-HCl 0.1 M 25.0 KCl 0.2 M HPLC GSSG, GSH 8.7 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0 1BPI 6.757499933242798 7681323 10.1021/bi00062a015 1993 ProTherm SAAFEC_S1262.csv 754 461 100 R74M Pancreatic trypsin inhibitor Bos taurus 75.0 74.8 yes 100.8 acetate/Na 10 mM DSC Thermal 4.3 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 2.0 1BPI 15.30727278102528 11910035 10.1110/ps.4460102 2002 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, HotMuSiC_S1626.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 8855 461 100 R74M Pancreatic trypsin inhibitor Bos taurus 12.4 yes GlyGly/HCl 10 mM 25.0 DSC Thermal 4.3 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 2.0 1BPI 15.30727278102528 11910035 10.1110/ps.4460102 2002 ProTherm 2971 1579 100 R74A Pancreatic trypsin inhibitor Bos taurus 41.0 0.0 Unknown 39.2 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 2.0 1BPI 15.30727278102528 7540212 10.1006/jmbi.1995.0304 1995 ProTherm AUTOMUTE_S1962.csv, capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, EASE-MM_S543.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S1791.csv 3567 1579 100 R74A Pancreatic trypsin inhibitor Bos taurus 0.0 yes 94.2 NaH2PO4 10 mM CD Thermal 3.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 2.0 1BPI 15.30727278102528 8784199 10.1021/bi960515w 1996 ProTherm AUTOMUTE_S1962.csv, capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv, Saraboji_S2204.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8190 1579 100 R74A Pancreatic trypsin inhibitor Bos taurus 0.0 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 2.0 1BPI 15.30727278102528 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 2972 1580 100 K76A Pancreatic trypsin inhibitor Bos taurus 34.0 -3.0 Unknown 36.2 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 8.0 1BPI 9.518888738420275 in pocket 7540212 10.1006/jmbi.1995.0304 1995 ProTherm Broom_S605.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1962.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8191 1580 100 K76A Pancreatic trypsin inhibitor Bos taurus 0.4 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 8.0 1BPI 9.518888738420275 in pocket 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 2973 1581 100 R77A Pancreatic trypsin inhibitor Bos taurus 40.0 -3.6 Unknown 35.6 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 4.0 1BPI 13.063636302947998 7540212 10.1006/jmbi.1995.0304 1995 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, EASE-MM_S543.csv, PoPMuSiC-2.0_S2648.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8192 1581 100 R77A Pancreatic trypsin inhibitor Bos taurus 0.5 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 4.0 1BPI 13.063636302947998 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1509 876 100 N78G Pancreatic trypsin inhibitor Bos taurus 46.0 -32.0 Unknown 55.0 glycine-HCl 10 mM NaCl 0.1 N DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0 1BPI 4.597499966621399 in pocket 7686069 10.1002/pro.5560020410 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 2986 876 100 N78G Pancreatic trypsin inhibitor Bos taurus 46.0 -32.0 Unknown 55.0 glycine-HCl 10 mM NaCl 0.1 N DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0 1BPI 4.597499966621399 in pocket 7690587 10.1021/bi00088a012 1993 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8764 876 100 N78G Pancreatic trypsin inhibitor Bos taurus 0.7 5.7 3.3 Unknown glycine-HCl 10 mM 25.0 NaCl 0.1 M DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0 1BPI 4.597499966621399 in pocket 7690587 10.1021/bi00088a012 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 9242 876 100 N78G Pancreatic trypsin inhibitor Bos taurus 5.7 3.3 Unknown glycine-HCl 10 mM 25.0 NaCl 0.1 N DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0 1BPI 4.597499966621399 in pocket 7686069 10.1002/pro.5560020410 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 2974 1582 100 N79A Pancreatic trypsin inhibitor Bos taurus -29.0 Unknown 15.0 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 8.0 1BPI 4.507500052452087 in pocket 7540212 10.1006/jmbi.1995.0304 1995 ProTherm AUTOMUTE_S1962.csv, Broom_S605.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8193 1582 100 N79A Pancreatic trypsin inhibitor Bos taurus 3.3 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 8.0 1BPI 4.507500052452087 in pocket 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 2987 1592 100 N79G Pancreatic trypsin inhibitor Bos taurus 49.0 -21.0 Unknown 66.0 glycine-HCl 10 mM NaCl 0.1 N DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 8.0 1BPI 4.507500052452087 in pocket 7690587 10.1021/bi00088a012 1993 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8765 1592 100 N79G Pancreatic trypsin inhibitor Bos taurus 0.7 4.7 4.3 Unknown glycine-HCl 10 mM 25.0 NaCl 0.1 M DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 8.0 1BPI 4.507500052452087 in pocket 7690587 10.1021/bi00088a012 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1510 877 100 F80A Pancreatic trypsin inhibitor Bos taurus 36.0 -38.0 Unknown 49.0 glycine-HCl 10 mM NaCl 0.1 N DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0 1BPI 5.1918182373046875 7686069 10.1002/pro.5560020410 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 9243 877 100 F80A Pancreatic trypsin inhibitor Bos taurus 6.9 2.1 Unknown glycine-HCl 10 mM 25.0 NaCl 0.1 N DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0 1BPI 5.1918182373046875 7686069 10.1002/pro.5560020410 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 12789 877 100 F80A Pancreatic trypsin inhibitor Bos taurus 2.7 6.8 2.2 0.83 yes (>90%) glycine 20 mM 20.0 CD GdnHCl 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0 1BPI 5.1918182373046875 11841216 10.1021/bi0116947 2002 ProTherm 11328 4821 100 F80L Pancreatic trypsin inhibitor Bos taurus 6.3 yes Tris-HCl 0.1 M 25.0 KCl 0.2 M Gel electrophoresis Urea 8.7 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 9.0 1BPI 5.1918182373046875 9232657 10.1002/pro.5560060720 1997 ProTherm 758 465 100 K81M Pancreatic trypsin inhibitor Bos taurus 80.2 82.2 yes 100.0 acetate/Na 10 mM DSC Thermal 4.3 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 4.0 1BPI 7.976666609446208 11910035 10.1110/ps.4460102 2002 ProTherm 8856 465 100 K81M Pancreatic trypsin inhibitor Bos taurus 13.8 yes GlyGly/HCl 10 mM 25.0 DSC Thermal 4.3 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 4.0 1BPI 7.976666609446208 11910035 10.1110/ps.4460102 2002 ProTherm 2975 1583 100 K81A Pancreatic trypsin inhibitor Bos taurus 42.0 0.6 Unknown 39.8 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 4.0 1BPI 7.976666609446208 7540212 10.1006/jmbi.1995.0304 1995 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q306.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3568 1583 100 K81A Pancreatic trypsin inhibitor Bos taurus 0.0 yes 94.2 NaH2PO4 10 mM CD Thermal 3.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 4.0 1BPI 7.976666609446208 8784199 10.1021/bi960515w 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8194 1583 100 K81A Pancreatic trypsin inhibitor Bos taurus -0.1 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 4.0 1BPI 7.976666609446208 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 2976 1584 100 S82A Pancreatic trypsin inhibitor Bos taurus 42.0 -11.9 Unknown 27.3 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 7.0 1BPI 5.271666685740153 7540212 10.1006/jmbi.1995.0304 1995 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q306.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8195 1584 100 S82A Pancreatic trypsin inhibitor Bos taurus 1.6 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 7.0 1BPI 5.271666685740153 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 755 462 100 E84M Pancreatic trypsin inhibitor Bos taurus 77.8 76.0 yes 98.0 acetate/Na 10 mM DSC Thermal 4.3 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 7.600000116560194 11910035 10.1110/ps.4460102 2002 ProTherm 8857 462 100 E84M Pancreatic trypsin inhibitor Bos taurus 12.6 yes GlyGly/HCl 10 mM 25.0 DSC Thermal 4.3 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 7.600000116560194 11910035 10.1110/ps.4460102 2002 ProTherm 2977 1585 100 E84A Pancreatic trypsin inhibitor Bos taurus 43.0 -1.3 Unknown 37.9 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 7.600000116560194 7540212 10.1006/jmbi.1995.0304 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8196 1585 100 E84A Pancreatic trypsin inhibitor Bos taurus 0.2 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 7.600000116560194 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 2978 1586 100 D85A Pancreatic trypsin inhibitor Bos taurus 44.0 -2.6 Unknown 36.6 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 6.866249918937683 7540212 10.1006/jmbi.1995.0304 1995 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, EASE-MM_S1676.csv, PON-TStab_dataset.csv, AUTOMUTE_S1749.csv, AUTOMUTE_S1962.csv, Saraboji_S1791.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 8197 1586 100 D85A Pancreatic trypsin inhibitor Bos taurus 0.4 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 6.866249918937683 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 126 83 100 M87L Pancreatic trypsin inhibitor Bos taurus 0.22 68.0 63.0 yes 83.3 glycine-HCl 10 mM DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 7.647499978542328 11274462 10.1110/ps.38101 2001 ProTherm 127 83 100 M87L Pancreatic trypsin inhibitor Bos taurus 0.3 70.0 67.8 yes 86.3 glycine-HCl 10 mM DSC Thermal 2.5 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 7.647499978542328 11274462 10.1110/ps.38101 2001 ProTherm 128 83 100 M87L Pancreatic trypsin inhibitor Bos taurus 0.35 71.0 69.8 yes 91.7 glycine-HCl 10 mM DSC Thermal 3.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 7.647499978542328 11274462 10.1110/ps.38101 2001 ProTherm 140 83 100 M87L Pancreatic trypsin inhibitor Bos taurus 45.0 yes 58.9 glycine-HCl 10 mM CD Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 7.647499978542328 11274462 10.1110/ps.38101 2001 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv 6466 83 100 M87L Pancreatic trypsin inhibitor Bos taurus 0.49 yes glycine-HCl 10 mM 89.0 DSC Thermal 3.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 7.647499978542328 11274462 10.1110/ps.38101 2001 ProTherm 6485 83 100 M87L Pancreatic trypsin inhibitor Bos taurus 0.6 yes glycine-HCl 10 mM 83.0 DSC Thermal 2.5 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 7.647499978542328 11274462 10.1110/ps.38101 2001 ProTherm 6516 83 100 M87L Pancreatic trypsin inhibitor Bos taurus 0.44 yes glycine-HCl 10 mM 81.0 DSC Thermal 2.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 7.647499978542328 11274462 10.1110/ps.38101 2001 ProTherm 2979 1587 100 M87A Pancreatic trypsin inhibitor Bos taurus 38.0 -12.1 Unknown 27.1 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 7.647499978542328 7540212 10.1006/jmbi.1995.0304 1995 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S499.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8198 1587 100 M87A Pancreatic trypsin inhibitor Bos taurus 1.7 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 7.647499978542328 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 756 463 100 R88M Pancreatic trypsin inhibitor Bos taurus 75.1 77.8 yes 97.3 acetate/Na 10 mM DSC Thermal 4.3 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 4.0 1BPI 8.863636363636363 11910035 10.1110/ps.4460102 2002 ProTherm 8858 463 100 R88M Pancreatic trypsin inhibitor Bos taurus 12.8 yes GlyGly/HCl 10 mM 25.0 DSC Thermal 4.3 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 4.0 1BPI 8.863636363636363 11910035 10.1110/ps.4460102 2002 ProTherm 2980 1588 100 R88A Pancreatic trypsin inhibitor Bos taurus 45.0 -0.9 Unknown 38.3 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 4.0 1BPI 8.863636363636363 7540212 10.1006/jmbi.1995.0304 1995 ProTherm AUTOMUTE_S1925.csv, AUTOMUTE_S1962.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, Broom_S605.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8199 1588 100 R88A Pancreatic trypsin inhibitor Bos taurus 0.1 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 4.0 1BPI 8.863636363636363 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 757 464 100 T89M Pancreatic trypsin inhibitor Bos taurus 78.2 76.8 yes 98.6 acetate/Na 10 mM DSC Thermal 4.3 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 8.158571379525322 11910035 10.1110/ps.4460102 2002 ProTherm 8859 464 100 T89M Pancreatic trypsin inhibitor Bos taurus 12.0 yes GlyGly/HCl 10 mM 25.0 DSC Thermal 4.3 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 8.158571379525322 11910035 10.1110/ps.4460102 2002 ProTherm 2981 1589 100 T89A Pancreatic trypsin inhibitor Bos taurus 43.0 -0.7 Unknown 38.5 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 8.158571379525322 7540212 10.1006/jmbi.1995.0304 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8200 1589 100 T89A Pancreatic trypsin inhibitor Bos taurus 0.1 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 8.158571379525322 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 2982 1590 100 G91A Pancreatic trypsin inhibitor Bos taurus 43.0 -1.4 Unknown 37.8 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 4.0 1BPI 8.299999833106995 7540212 10.1006/jmbi.1995.0304 1995 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, SVM-WIN31_SVM-3D12_S499.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8201 1590 100 G91A Pancreatic trypsin inhibitor Bos taurus 0.2 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 4.0 1BPI 8.299999833106995 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 2983 1591 100 G92A Pancreatic trypsin inhibitor Bos taurus 44.0 -1.5 Unknown 37.7 phosphate 10 mM NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 10.902499914169312 7540212 10.1006/jmbi.1995.0304 1995 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S499.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8202 1591 100 G92A Pancreatic trypsin inhibitor Bos taurus 0.2 Unknown phosphate 10 mM 39.0 NaCl 150 mM DSC Thermal 7.0 P00974 IPR002223:Kunitz_BPTI, IPR036880:Kunitz_BPTI_sf, IPR020901:Prtase_inh_Kunz-CS, IPR050098:TFPI/VKTCI-like 5.0 1BPI 10.902499914169312 7540212 10.1006/jmbi.1995.0304 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 17510 95 84 Hordeum vulgare no 74.3 acetate 10 mM CD Thermal 4.15 Q40059 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7908135 10.1093/protein/7.1.103 1994 ProTherm 20472 95 84 Hordeum vulgare 4.05 7.16 1.76 yes MES-NaOH 50 mM 25.0 DSC GdnHCl 6.3 Q40059 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7908135 10.1093/protein/7.1.103 1994 ProTherm 20533 95 84 Hordeum vulgare 0.79 1.94 yes glycine-HCl 10 mM 25.0 DSC Thermal 2.2 Q40059 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 1931967 10.1021/bi00107a010 1991 ProTherm 20534 95 84 Hordeum vulgare 0.79 2.79 yes glycine-HCl 10 mM 25.0 DSC Thermal 2.5 Q40059 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 1931967 10.1021/bi00107a010 1991 ProTherm 20535 95 84 Hordeum vulgare 0.79 3.73 yes glycine-HCl 10 mM 25.0 DSC Thermal 2.8 Q40059 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 1931967 10.1021/bi00107a010 1991 ProTherm 20536 95 84 Hordeum vulgare 0.79 5.2 yes glycine-HCl 10 mM 25.0 DSC Thermal 3.2 Q40059 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 1931967 10.1021/bi00107a010 1991 ProTherm 20537 95 84 Hordeum vulgare 0.79 6.48 yes glycine-HCl 10 mM 25.0 DSC Thermal 3.5 Q40059 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 1931967 10.1021/bi00107a010 1991 ProTherm 26328 95 84 Hordeum vulgare 7.41 1.96 unknown Sodium phosphate 20 mM 25.0 Fluorescence GdnHCl 6.3 Q40059 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 16452617 10.1110/ps.051851506 2006 ProTherm 26329 95 84 Hordeum vulgare 7.27 2.01 unknown Sodium phosphate 20 mM 25.0 Fluorescence GdnHCl 6.3 Q40059 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 16452617 10.1110/ps.051851506 2006 ProTherm 26330 95 84 Hordeum vulgare 7.22 1.96 unknown Sodium phosphate 20 mM 25.0 Fluorescence GdnHCl 6.3 Q40059 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 16452617 10.1110/ps.051851506 2006 ProTherm 143 86 84 K44A Hordeum vulgare 1.3 no 73.0 acetate 10 mM CD Thermal 4.15 Q40059 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 7908135 10.1093/protein/7.1.103 1994 ProTherm AUTOMUTE_S1749.csv 145 86 84 K44A Hordeum vulgare no 74.3 acetate 10 mM CD Thermal 4.15 Q40059 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 7908135 10.1093/protein/7.1.103 1994 ProTherm EASE-MM_S1676.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, Saraboji_S1396.csv 6569 86 84 K44A Hordeum vulgare -0.26 no acetate 10 mM 74.3 CD Thermal 4.15 Q40059 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 7908135 10.1093/protein/7.1.103 1994 ProTherm khan_protherm_data_mapped.csv 8602 86 84 K44A Hordeum vulgare 3.69 6.52 1.76 yes MES-NaOH 50 mM 25.0 DSC GdnHCl 6.3 Q40059 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 7908135 10.1093/protein/7.1.103 1994 ProTherm 8604 86 84 K44A Hordeum vulgare -0.64 yes MES-NaOH 50 mM 25.0 DSC GdnHCl 6.3 Q40059 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 7.0 7908135 10.1093/protein/7.1.103 1994 ProTherm 144 87 84 P45A Hordeum vulgare 9.1 no 65.2 acetate 10 mM CD Thermal 4.15 Q40059 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 7908135 10.1093/protein/7.1.103 1994 ProTherm AUTOMUTE_S1749.csv 146 87 84 P45A Hordeum vulgare no 74.3 acetate 10 mM CD Thermal 4.15 Q40059 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 7908135 10.1093/protein/7.1.103 1994 ProTherm 6570 87 84 P45A Hordeum vulgare -1.82 no acetate 10 mM 74.3 CD Thermal 4.15 Q40059 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 7908135 10.1093/protein/7.1.103 1994 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, khan_protherm_data_mapped.csv 8603 87 84 P45A Hordeum vulgare 2.96 5.23 1.95 yes MES-NaOH 50 mM 25.0 DSC GdnHCl 6.3 Q40059 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 7908135 10.1093/protein/7.1.103 1994 ProTherm 8605 87 84 P45A Hordeum vulgare -1.93 yes MES-NaOH 50 mM 25.0 DSC GdnHCl 6.3 Q40059 IPR000864:Prot_inh_pot1, IPR036354:Prot_inh_pot1_sf 5.0 7908135 10.1093/protein/7.1.103 1994 ProTherm 17696 117 231 Thermonuclease Staphylococcus aureus 2.2 79.0 112.3 yes 51.5 phosphate 0.05 M NaCl 0.1 M DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8518730 10.1002/pro.5560020408 1993 ProTherm 17697 117 231 Thermonuclease Staphylococcus aureus 2.2 53.0 88.2 yes 47.0 phosphate 0.05 M NaCl 0.1 M DSC Thermal 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8518730 10.1002/pro.5560020408 1993 ProTherm 17942 117 231 Thermonuclease Staphylococcus aureus 73.9 Unknown 52.5 cacodylate/pdTp 10 mM/0.1 mM CaCl2 10 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 1652762 10.1073/pnas.88.17.7715 1991 ProTherm 17969 117 231 Thermonuclease Staphylococcus aureus 2.0 93.0 yes 58.2 phosphate 10 mM NaCl 0.1 M DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7756977 10.1002/pro.5560031203 1994 ProTherm 17970 117 231 Thermonuclease Staphylococcus aureus 2.05 59.0 yes 43.6 acetate 10 mM NaCl 0.1 M DSC Thermal 4.1 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7756977 10.1002/pro.5560031203 1994 ProTherm 17971 117 231 Thermonuclease Staphylococcus aureus 1.36 33.0 yes 33.1 glycine-HCl 10 mM NaCl 0.1 M DSC Thermal 3.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7756977 10.1002/pro.5560031203 1994 ProTherm 17972 117 231 Thermonuclease Staphylococcus aureus 1.05 38.0 yes 3.0 33.9 glycine-HCl 10 mM NaCl 0.5 M DSC Thermal 3.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7756977 10.1002/pro.5560031203 1994 ProTherm 17973 117 231 Thermonuclease Staphylococcus aureus 0.51 21.5 yes 3.0 60.4 glycine-HCl 10 mM NaCl 0.5 M DSC Thermal 3.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7756977 10.1002/pro.5560031203 1994 ProTherm 18285 117 231 Thermonuclease Staphylococcus aureus yes 53.4 Sodium phosphate,Sodium sulfate, 10 mM,10 mM, Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8355268 10.1006/jmbi.1993.1425 1993 ProTherm 18290 117 231 Thermonuclease Staphylococcus aureus 2.15 77.5 yes 54.1 Sodium phosphate 20 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8069224 10.1002/pro.5560030610 1994 ProTherm 18291 117 231 Thermonuclease Staphylococcus aureus 1.32 43.06 yes 42.5 glycine-HCl 20 mM NaCl 100 mM CD Thermal 4.1 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8069224 10.1002/pro.5560030610 1994 ProTherm 18313 117 231 Thermonuclease Staphylococcus aureus yes 54.1 Sodium phosphate 20 mM NaCl 100 mM DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7849061 10.1021/bi00006a025 1995 ProTherm 18331 117 231 Thermonuclease Staphylococcus aureus 77.5 yes 54.1 Sodium phosphate 20 mM NaCl 100 mM DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8075087 10.1021/bi00201a035 1994 ProTherm 18332 117 231 Thermonuclease Staphylococcus aureus 73.2 yes 50.8 Sodium acetate 20 mM NaCl 100 mM DSC Thermal 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8069223 10.1002/pro.5560030609 1994 ProTherm 18333 117 231 Thermonuclease Staphylococcus aureus 78.5 yes 53.4 Sodium acetate 20 mM NaCl 100 mM DSC Thermal 6.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8069223 10.1002/pro.5560030609 1994 ProTherm 18334 117 231 Thermonuclease Staphylococcus aureus 77.5 yes 54.1 Sodium phosphate 20 mM NaCl 100 mM DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8069223 10.1002/pro.5560030609 1994 ProTherm 18335 117 231 Thermonuclease Staphylococcus aureus 83.7 yes 53.5 Sodium phosphate 20 mM NaCl 100 mM DSC Thermal 8.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8069223 10.1002/pro.5560030609 1994 ProTherm 18517 117 231 Thermonuclease Staphylococcus aureus 82.6 yes 50.6 Tris-HCl 0.01 M NaCl 0.1 M Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 1991099 10.1021/bi00219a005 1991 ProTherm 18541 117 231 Thermonuclease Staphylococcus aureus 62.2 yes 47.8 Unknown NaCl 0.3 M NMR Thermal 5.31 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 2372535 10.1021/bi00471a003 1990 ProTherm 18816 117 231 Thermonuclease Staphylococcus aureus 78.7 yes 53.1 PIPES 0.05 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8672513 10.1021/bi9530090 1996 ProTherm 18940 117 231 Thermonuclease Staphylococcus aureus 81.0 yes 53.0 cacodylate 10 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 2373696 1990 ProTherm 19631 117 231 Thermonuclease Staphylococcus aureus 86.0 yes 53.5 NaOH 25 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8648619 10.1006/jmbi.1996.0180 1996 ProTherm 19888 117 231 Thermonuclease Staphylococcus aureus yes 53.0 Sodium phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8580845 10.1002/pro.5560041211 1995 ProTherm 20167 117 231 Thermonuclease Staphylococcus aureus 0.61 yes Bis-tris 50 mM 45.0 Absorbance Pressure 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 10194332 10.1021/bi982608e 1999 ProTherm 20177 117 231 Thermonuclease Staphylococcus aureus 0.0 1.4 yes Unknown 40.0 NaCl 0.3 M NMR Thermal 5.31 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 2372535 10.1021/bi00471a003 1990 ProTherm 20179 117 231 Thermonuclease Staphylococcus aureus 1.2 yes Bis-tris 10 mM 40.0 Fluorescence Pressure 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 10194332 10.1021/bi982608e 1999 ProTherm 20180 117 231 Thermonuclease Staphylococcus aureus 2.1 yes Bis-tris 50 mM 40.0 Absorbance Pressure 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 10194332 10.1021/bi982608e 1999 ProTherm 20231 117 231 Thermonuclease Staphylococcus aureus 6.44 yes succinate 50 mM 37.0 NMR Urea 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8218167 10.1021/bi00092a011 1993 ProTherm 20232 117 231 Thermonuclease Staphylococcus aureus 6.13 yes succinate 50 mM 37.0 Fluorescence Urea 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8218167 10.1021/bi00092a011 1993 ProTherm 20287 117 231 Thermonuclease Staphylococcus aureus 3.1 yes Bis-tris 50 mM 36.0 Absorbance Pressure 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 10194332 10.1021/bi982608e 1999 ProTherm 20312 117 231 Thermonuclease Staphylococcus aureus 0.61 5.88 Unknown phosphate 25 mM 35.0 NaCl 0.1 M Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 10460179 10.1021/bi9909400 1999 ProTherm 20329 117 231 Thermonuclease Staphylococcus aureus 2.1 yes Bis-tris 10 mM 30.0 Fluorescence Pressure 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 10194332 10.1021/bi982608e 1999 ProTherm 20350 117 231 Thermonuclease Staphylococcus aureus 0.72 5.78 Unknown phosphate 25 mM 30.0 NaCl 0.1 M Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 10460179 10.1021/bi9909400 1999 ProTherm 20637 117 231 Thermonuclease Staphylococcus aureus 4.0 yes Bis-tris 50 mM 25.0 Absorbance Pressure 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 10194332 10.1021/bi982608e 1999 ProTherm 21082 117 231 Thermonuclease Staphylococcus aureus 0.8 6.0 Unknown phosphate 25 mM 25.0 NaCl 0.1 M Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 10460179 10.1021/bi9909400 1999 ProTherm 21083 117 231 Thermonuclease Staphylococcus aureus 0.77 6.5 Unknown phosphate 25 mM 25.0 NaCl 0.1 M DSC GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 10460179 10.1021/bi9909400 1999 ProTherm 21207 117 231 Thermonuclease Staphylococcus aureus 3.8 5.9 Unknown Sodium acetate 50 mM 25.0 NaCl 100 mM Fluorescence GdnHCl 5.6 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 10467101 10.1038/12338 1999 ProTherm 21208 117 231 Thermonuclease Staphylococcus aureus 4.0 5.5 Unknown Sodium acetate 50 mM 25.0 NaCl 100 mM Fluorescence GdnHCl 5.2 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 10467101 10.1038/12338 1999 ProTherm 21361 117 231 Thermonuclease Staphylococcus aureus 4.5 Unknown phosphate 10 mM 25.0 DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8637910 10.1073/pnas.93.6.2539 1996 ProTherm 21362 117 231 Thermonuclease Staphylococcus aureus 5.2 Unknown phosphate 10 mM 25.0 DSC Thermal 3.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8637910 10.1073/pnas.93.6.2539 1996 ProTherm 21581 117 231 Thermonuclease Staphylococcus aureus 3.2 yes Bis-tris 10 mM 21.0 Fluorescence Pressure 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 10194332 10.1021/bi982608e 1999 ProTherm 21591 117 231 Thermonuclease Staphylococcus aureus 3.2 Unknown Bis-Tris 10 mM 21.0 Fluorescence Pressure 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9792110 10.1002/pro.5560071020 1998 ProTherm 21645 117 231 Thermonuclease Staphylococcus aureus 0.84 5.6 1.0 Unknown Tris-HCl 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 1920420 10.1016/0022-2836(91)80195-z 1991 ProTherm 21646 117 231 Thermonuclease Staphylococcus aureus 0.83 5.2 0.95 Unknown Tris-HCl 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 8.8 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 1920420 10.1016/0022-2836(91)80195-z 1991 ProTherm 21647 117 231 Thermonuclease Staphylococcus aureus 0.74 4.5 0.91 Unknown ethanolamine-HCl 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 9.6 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 1920420 10.1016/0022-2836(91)80195-z 1991 ProTherm 21648 117 231 Thermonuclease Staphylococcus aureus 5.6 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8639591 10.1021/bi960171+ 1996 ProTherm 21661 117 231 Thermonuclease Staphylococcus aureus 4.6 yes Bis-tris 50 mM 20.0 Absorbance Pressure 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 10194332 10.1021/bi982608e 1999 ProTherm 21662 117 231 Thermonuclease Staphylococcus aureus 0.8 5.5 1.0 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 1610820 10.1021/bi00140a005 1992 ProTherm 21669 117 231 Thermonuclease Staphylococcus aureus 5.6 yes Na3PO4 25 mM 20.0 NaCl 0.1 M Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3167015 10.1021/bi00413a027 1988 ProTherm 21670 117 231 Thermonuclease Staphylococcus aureus 0.0 6.8 yes Na2HPO4 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 2381904 10.1002/prot.340070402 1990 ProTherm 21672 117 231 Thermonuclease Staphylococcus aureus 0.84 5.0 1.0 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9315853 10.1021/bi970876r 1997 ProTherm 21673 117 231 Thermonuclease Staphylococcus aureus 0.79 5.33 6.72 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8355268 10.1006/jmbi.1993.1425 1993 ProTherm 21674 117 231 Thermonuclease Staphylococcus aureus 0.8 5.02 6.15 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM CD GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8355268 10.1006/jmbi.1993.1425 1993 ProTherm 21675 117 231 Thermonuclease Staphylococcus aureus 0.82 5.6 1.0 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3449854 10.1002/prot.340010113 1986 ProTherm 21676 117 231 Thermonuclease Staphylococcus aureus 2.56 6.1 1.0 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence Urea 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3449854 10.1002/prot.340010113 1986 ProTherm 21680 117 231 Thermonuclease Staphylococcus aureus 0.83 5.5 1.0 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9578580 10.1021/bi9725069 1998 ProTherm 21707 117 231 Thermonuclease Staphylococcus aureus 5.48 6.85 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 2261461 10.1021/bi00487a007 1990 ProTherm 21708 117 231 Thermonuclease Staphylococcus aureus 0.85 5.5 1.0 Unknown Potassium phosphate 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 2015219 10.1021/bi00229a005 1991 ProTherm 21718 117 231 Thermonuclease Staphylococcus aureus 5.32 5.83 yes PIPES 0.05 mM 20.0 CD GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8672513 10.1021/bi9530090 1996 ProTherm 21725 117 231 Thermonuclease Staphylococcus aureus 0.83 5.6 1.0 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7577991 10.1021/bi00042a029 1995 ProTherm 21746 117 231 Thermonuclease Staphylococcus aureus 0.84 5.72 Unknown phosphate 25 mM 20.0 NaCl 0.1 M Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 10460179 10.1021/bi9909400 1999 ProTherm 21751 117 231 Thermonuclease Staphylococcus aureus 5.5 6.8 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 10467101 10.1038/12338 1999 ProTherm 21763 117 231 Thermonuclease Staphylococcus aureus 0.83 5.5 6.6 yes NaOH 25 mM 20.0 Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8648619 10.1006/jmbi.1996.0180 1996 ProTherm 21794 117 231 Thermonuclease Staphylococcus aureus 5.66 Unknown Tris-HCl 0.01 M 20.0 NaCl 0.1 M Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8161701 10.1016/s0006-3495(94)80799-4 1994 ProTherm 21795 117 231 Thermonuclease Staphylococcus aureus 0.8 5.4 1.0 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM CD GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm 21824 117 231 Thermonuclease Staphylococcus aureus 0.84 5.5 6.6 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8580845 10.1002/pro.5560041211 1995 ProTherm 21909 117 231 Thermonuclease Staphylococcus aureus 0.9 5.65 Unknown phosphate 25 mM 15.2 NaCl 0.1 M Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 10460179 10.1021/bi9909400 1999 ProTherm 21912 117 231 Thermonuclease Staphylococcus aureus 4.5 yes Bis-tris 50 mM 15.0 Absorbance Pressure 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 10194332 10.1021/bi982608e 1999 ProTherm 21957 117 231 Thermonuclease Staphylococcus aureus 3.2 yes Bis-tris 10 mM 10.0 Fluorescence Pressure 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 10194332 10.1021/bi982608e 1999 ProTherm 21958 117 231 Thermonuclease Staphylococcus aureus 4.15 yes Bis-tris 50 mM 10.0 Absorbance Pressure 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 10194332 10.1021/bi982608e 1999 ProTherm 22016 117 231 Thermonuclease Staphylococcus aureus 3.0 yes Bis-tris 50 mM 5.0 Absorbance Pressure 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 10194332 10.1021/bi982608e 1999 ProTherm 22040 117 231 Thermonuclease Staphylococcus aureus 3.7 yes Sodium cacodylate 50 mM 4.5 NaCl 50 mM CD Urea 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 2001357 10.1021/bi00224a018 1991 ProTherm 22064 117 231 Thermonuclease Staphylococcus aureus 2.6 yes Bis-tris 10 mM 2.0 Fluorescence Pressure 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 10194332 10.1021/bi982608e 1999 ProTherm 22067 117 231 Thermonuclease Staphylococcus aureus 2.2 yes Bis-tris 50 mM 0.5 Absorbance Pressure 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 10194332 10.1021/bi982608e 1999 ProTherm 22068 117 231 Thermonuclease Staphylococcus aureus 0.3 4.6 Unknown cacodylate/pdTp 10 mM/0.1 mM 0.0 CaCl2 10 mM CD GdnSCN 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 1652762 10.1073/pnas.88.17.7715 1991 ProTherm 22072 117 231 Thermonuclease Staphylococcus aureus 0.3 4.6 14.0 yes cacodylate 10 mM 0.0 Fluorescence GdnSCN 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8448112 10.1021/bi00061a010 1993 ProTherm 22083 117 231 Thermonuclease Staphylococcus aureus 2.0 yes Bis-tris 50 mM -4.5 Absorbance Pressure 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 10194332 10.1021/bi982608e 1999 ProTherm 22374 117 231 Thermonuclease Staphylococcus aureus 2.2 84.1 Unknown 52.0 phosphate DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 11598114 10.1074/jbc.M106620200 2001 ProTherm 22814 117 231 Thermonuclease Staphylococcus aureus 85.2 yes 66.3 sodium phosphate 25mM NaCl 50 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 15066439 10.1016/j.jmb.2004.02.044 2004 ProTherm 22959 117 231 Thermonuclease Staphylococcus aureus 71.0 Unknown 51.2 MOPS 10 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 12211005 10.1002/prot.10216 2002 ProTherm 23011 117 231 Thermonuclease Staphylococcus aureus 79.59 Unknown 50.7 MOPS 10 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 15573380 10.1002/prot.20333 2005 ProTherm 23477 117 231 Thermonuclease Staphylococcus aureus 89.0 Unknown 52.7 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 23478 117 231 Thermonuclease Staphylococcus aureus 82.4 Unknown 53.0 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 24056 117 231 Thermonuclease Staphylococcus aureus Unknown 53.0 MOPS 25 mM Potassium chloride 100 mM Quantitative cysteine reactivity Thermal 7.6 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 20194783 10.1073/pnas.0910421107 2010 ProTherm 25308 117 231 Thermonuclease Staphylococcus aureus 2.25 Unknown MOPS 10 mM 40.0 CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 12211005 10.1002/prot.10216 2002 ProTherm 25541 117 231 Thermonuclease Staphylococcus aureus 2.3 4.6 2.0 Unknown Tris-HCl 100 mM 25.0 Fluorescence Urea 7.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 11329280 10.1021/bi000861k 2001 ProTherm 25542 117 231 Thermonuclease Staphylococcus aureus 4.5 5.6 1.2 Unknown Tris-HCl 100 mM 25.0 KCl 2.6 M Fluorescence Urea 7.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 11329280 10.1021/bi000861k 2001 ProTherm 25543 117 231 Thermonuclease Staphylococcus aureus 4.2 6.9 1.7 Unknown Tris-HCl 100 mM 25.0 Na2SO4 0.4 M Fluorescence Urea 7.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 11329280 10.1021/bi000861k 2001 ProTherm 26552 117 231 Thermonuclease Staphylococcus aureus 0.82 Unknown Phosphate 25.0 Fluorescence GdnHCl 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 20688426 10.1016/j.bpc.2010.07.001 2010 ProTherm 26553 117 231 Thermonuclease Staphylococcus aureus 0.8 Unknown Phosphate 25.0 CD GdnHCl 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 20688426 10.1016/j.bpc.2010.07.001 2010 ProTherm 26554 117 231 Thermonuclease Staphylococcus aureus 0.4 Unknown Tris-HCl 25 mM 25.0 Calcium chloride 10 mM Fluorescence Activity 8.8 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 20688426 10.1016/j.bpc.2010.07.001 2010 ProTherm 26968 117 231 Thermonuclease Staphylococcus aureus 0.82 5.4 1.0 Unknown sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 11438757 10.1093/protein/14.5.343 2001 ProTherm 26970 117 231 Thermonuclease Staphylococcus aureus 0.82 5.4 6.53 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 11705393 10.1021/bi011269d 2001 ProTherm 27056 117 231 Thermonuclease Staphylococcus aureus 0.82 5.4 6.53 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 12549934 10.1021/bi0266434 2003 ProTherm 27084 117 231 Thermonuclease Staphylococcus aureus 6.1 yes sodium phosphate 25mM 20.0 NaCl 50 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 15066439 10.1016/j.jmb.2004.02.044 2004 ProTherm 27092 117 231 Thermonuclease Staphylococcus aureus 0.82 5.4 1.0 Unknown Sodium phosphate, sodium chloride 25 mM, 100 mM 20.0 Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 15504416 10.1016/j.jmb.2004.09.008 2004 ProTherm 13547 6345 231 S28G Thermonuclease Staphylococcus aureus 4.71 0.96 Unknown Tris-HCl 0.01 M 20.0 NaCl 0.1 M Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 8161701 10.1016/s0006-3495(94)80799-4 1994 ProTherm 14373 6345 231 S28G Thermonuclease Staphylococcus aureus 0.04 0.96 Unknown cacodylate/pdTp 10 mM/0.1 mM 0.0 CaCl2 10 mM CD GdnSCN 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 1652762 10.1073/pnas.88.17.7715 1991 ProTherm 13081 6165 231 T86G Thermonuclease Staphylococcus aureus 0.79 0.2 5.3 0.99 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 2.0 1STN 1610820 10.1021/bi00140a005 1992 ProTherm 13082 6166 231 T86A Thermonuclease Staphylococcus aureus 0.78 0.2 5.3 0.99 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 2.0 1STN 1610820 10.1021/bi00140a005 1992 ProTherm 12852 5979 231 K87A Thermonuclease Staphylococcus aureus 0.83 -0.3 5.9 1.04 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 1.0 1STN 8639591 10.1021/bi960171+ 1996 ProTherm 12853 5980 231 K87G Thermonuclease Staphylococcus aureus 0.82 -0.3 5.9 1.04 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 1.0 1STN 8639591 10.1021/bi960171+ 1996 ProTherm 12854 5981 231 K88A Thermonuclease Staphylococcus aureus 0.81 -0.3 5.9 1.05 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 1.0 1STN 52.706666734483505 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 12855 5982 231 K88G Thermonuclease Staphylococcus aureus 0.83 -0.3 5.9 1.02 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 1.0 1STN 52.706666734483505 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 3004 1601 231 L89A Thermonuclease Staphylococcus aureus -3.2 yes 50.9 Sodium phosphate 20 mM NaCl 100 mM DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 2.0 1STN 27.631250143051147 7849061 10.1021/bi00006a025 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 13403 1601 231 L89A Thermonuclease Staphylococcus aureus 0.6 1.6 3.88 0.89 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 2.0 1STN 27.631250143051147 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12755 5911 231 L89I Thermonuclease Staphylococcus aureus 0.72 0.9 4.5 6.3 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 2.0 1STN 27.631250143051147 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv 12756 5912 231 L89V Thermonuclease Staphylococcus aureus 0.68 1.4 4.0 5.9 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 2.0 1STN 27.631250143051147 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv 13404 6282 231 L89G Thermonuclease Staphylococcus aureus 0.6 1.5 3.98 0.89 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 2.0 1STN 27.631250143051147 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 15525 7216 231 L89A, V105F Thermonuclease Staphylococcus aureus 3.65 0.71 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 2.0, 6.0 1STN 27.631250143051147, 12.74000004359654 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15526 7217 231 L89A, L119A Thermonuclease Staphylococcus aureus 1.65 0.88 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 2.0, 9.0 1STN 27.631250143051147, 12.043750047683716 in tunnel in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15527 7218 231 L89A, E157V Thermonuclease Staphylococcus aureus 3.64 0.73 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 2.0, 8.0 1STN 27.631250143051147, 12.881110933091906 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15528 7219 231 L89A, G161S Thermonuclease Staphylococcus aureus 2.77 0.8 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 2.0, 6.0 1STN 27.631250143051147, 12.882500171661377 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15555 7245 231 L89A, I97V Thermonuclease Staphylococcus aureus 2.08 0.96 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 2.0, 4.0 1STN 27.631250143051147, 17.287500143051147 8399139 10.1021/bi00089a032 1993 ProTherm 15556 7246 231 L89A, I154V Thermonuclease Staphylococcus aureus 2.41 1.01 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 2.0, 8.0 1STN 27.631250143051147, 10.5625 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15557 7247 231 L89A, Y167A Thermonuclease Staphylococcus aureus 1.6 0.95 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 2.0, 9.0 1STN 27.631250143051147, 18.133333285649616 in tunnel in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15558 7248 231 L89A, I174V Thermonuclease Staphylococcus aureus 1.54 0.96 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 2.0, 8.0 1STN 27.631250143051147, 9.303750038146973 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15559 7249 231 L89A, Y195A Thermonuclease Staphylococcus aureus 1.1 0.96 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 2.0, 9.0 1STN 27.631250143051147, 33.795000076293945 in tunnel in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15560 7250 231 L89A, A212G Thermonuclease Staphylococcus aureus 2.46 0.87 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 2.0, 4.0 1STN 27.631250143051147, 13.848000144958496 8399139 10.1021/bi00089a032 1993 ProTherm 12898 6023 231 H90A Thermonuclease Staphylococcus aureus 0.72 0.4 5.2 1.04 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 45.828000450134276 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 12899 6024 231 H90G Thermonuclease Staphylococcus aureus 0.67 0.8 4.8 1.03 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 45.828000450134276 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12856 5983 231 K91A Thermonuclease Staphylococcus aureus 0.6 1.4 4.2 0.99 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 26.537777582804363 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12857 5984 231 K91G Thermonuclease Staphylococcus aureus 0.53 1.9 3.7 0.99 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 26.537777582804363 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13330 6242 231 K91F Thermonuclease Staphylococcus aureus 0.7 1.2 4.3 0.93 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 26.537777582804363 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv 12828 5958 231 E92A Thermonuclease Staphylococcus aureus 0.6 1.3 4.3 1.03 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 30.232222663031685 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12829 5959 231 E92G Thermonuclease Staphylococcus aureus 0.52 1.8 3.8 1.03 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 30.232222663031685 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12916 6041 231 E92K Thermonuclease Staphylococcus aureus 0.55 2.2 3.2 5.81 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 30.232222663031685 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv 12917 6042 231 E92Q Thermonuclease Staphylococcus aureus 0.72 1.3 4.1 5.74 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 30.232222663031685 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv 13024 6113 231 P93G Thermonuclease Staphylococcus aureus 0.67 1.0 4.5 0.99 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 1.0 1STN 16.984285763331822 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13025 6114 231 P93A Thermonuclease Staphylococcus aureus 0.75 0.4 5.1 1.0 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 1.0 1STN 16.984285763331822 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 13331 6243 231 P93F Thermonuclease Staphylococcus aureus 0.79 0.6 4.9 0.94 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 1.0 1STN 16.984285763331822 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 12998 6087 231 A94G Thermonuclease Staphylococcus aureus 0.46 2.4 3.1 0.99 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 12.417999839782714 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12999 6088 231 A94V Thermonuclease Staphylococcus aureus 0.7 1.1 4.4 0.92 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 12.417999839782714 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm SAAFEC_S1262.csv 2408 1244 231 T95S Thermonuclease Staphylococcus aureus 85.0 -1.6 Unknown 51.1 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 14.648571423121862 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv 2503 1244 231 T95S Thermonuclease Staphylococcus aureus 86.0 -0.5 Unknown 52.5 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 14.648571423121862 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 13510 1244 231 T95S Thermonuclease Staphylococcus aureus 0.77 0.3 5.3 1.02 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 14.648571423121862 in pocket 7577991 10.1021/bi00042a029 1995 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 2416 1252 231 T95V Thermonuclease Staphylococcus aureus 87.0 -1.6 Unknown 51.1 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 14.648571423121862 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, HotMuSiC_S1626.csv 2511 1252 231 T95V Thermonuclease Staphylococcus aureus 80.0 -0.6 Unknown 52.4 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 14.648571423121862 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm STRUM_Q306.csv, STRUM_Q3421.csv 13518 1252 231 T95V Thermonuclease Staphylococcus aureus 0.81 0.4 5.2 0.96 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 14.648571423121862 in pocket 7577991 10.1021/bi00042a029 1995 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 2424 1260 231 T95C Thermonuclease Staphylococcus aureus 80.0 -3.8 Unknown 48.9 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 14.648571423121862 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1925.csv, AUTOMUTE_S1962.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, EASE-MM_S1676.csv, HotMuSiC_S1626.csv, PON-TStab_dataset.csv 2519 1260 231 T95C Thermonuclease Staphylococcus aureus 78.0 -2.9 Unknown 50.1 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 14.648571423121862 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm Broom_S605.csv, STRUM_Q3421.csv, EASE-MM_S543.csv, PoPMuSiC-2.0_S2648.csv 13526 1260 231 T95C Thermonuclease Staphylococcus aureus 0.68 1.4 4.2 0.92 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 14.648571423121862 in pocket 7577991 10.1021/bi00042a029 1995 ProTherm SAAFEC_S1262.csv 12777 5933 231 T95I Thermonuclease Staphylococcus aureus 0.82 0.1 5.3 6.5 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 14.648571423121862 in pocket 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 13083 6167 231 T95G Thermonuclease Staphylococcus aureus 0.62 1.1 4.4 1.03 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 14.648571423121862 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13084 6168 231 T95A Thermonuclease Staphylococcus aureus 0.69 0.7 4.8 1.02 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 14.648571423121862 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12757 5913 231 L96I Thermonuclease Staphylococcus aureus 0.56 1.5 3.9 7.05 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 14.039999961853027 in pocket 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv 12758 5914 231 L96V Thermonuclease Staphylococcus aureus 0.55 1.5 3.9 7.14 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 14.039999961853027 in pocket 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv 13405 6283 231 L96A Thermonuclease Staphylococcus aureus 0.4 2.3 3.18 1.05 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 14.039999961853027 in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13406 6284 231 L96G Thermonuclease Staphylococcus aureus 0.2 3.7 1.78 1.18 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 14.039999961853027 in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12744 5901 231 I97L Thermonuclease Staphylococcus aureus 0.72 0.6 4.8 6.65 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 17.287500143051147 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 12745 5902 231 I97M Thermonuclease Staphylococcus aureus 0.82 0.3 5.1 6.18 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 17.287500143051147 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 13436 6304 231 I97V Thermonuclease Staphylococcus aureus 0.6 0.8 4.68 1.05 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 17.287500143051147 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13437 6305 231 I97A Thermonuclease Staphylococcus aureus 0.3 2.7 2.28 1.05 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 17.287500143051147 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13584 6305 231 I97A Thermonuclease Staphylococcus aureus 0.39 2.6 2.8 1.07 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 17.287500143051147 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm SAAFEC_S1262.csv 13438 6306 231 I97G Thermonuclease Staphylococcus aureus 0.2 3.3 2.18 1.12 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 17.287500143051147 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13585 6306 231 I97G Thermonuclease Staphylococcus aureus 0.28 3.3 2.1 1.15 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 17.287500143051147 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 15514 7206 231 I97V, I154V Thermonuclease Staphylococcus aureus 2.01 1.12 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0, 8.0 1STN 17.287500143051147, 10.5625 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15515 7207 231 I97V, Y167V Thermonuclease Staphylococcus aureus 1.06 1.09 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0, 9.0 1STN 17.287500143051147, 18.133333285649616 in tunnel in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15516 7208 231 I97V, Y195A Thermonuclease Staphylococcus aureus 0.62 1.08 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0, 9.0 1STN 17.287500143051147, 33.795000076293945 in tunnel in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15561 7251 231 V105F, I97V Thermonuclease Staphylococcus aureus 2.59 0.96 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0, 6.0 1STN 17.287500143051147, 12.74000004359654 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15567 7257 231 L119A, I97V Thermonuclease Staphylococcus aureus 2.17 1.01 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0, 9.0 1STN 17.287500143051147, 12.043750047683716 in tunnel in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15573 7263 231 E157V, I97V Thermonuclease Staphylococcus aureus 2.83 0.87 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0, 8.0 1STN 17.287500143051147, 12.881110933091906 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15579 7269 231 G161S, I97V Thermonuclease Staphylococcus aureus 3.1 0.95 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0, 6.0 1STN 17.287500143051147, 12.882500171661377 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 12858 5985 231 K98A Thermonuclease Staphylococcus aureus 0.81 0.2 5.4 0.96 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 27.371111128065323 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 13576 5985 231 K98A Thermonuclease Staphylococcus aureus 0.81 0.2 5.2 0.96 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 27.371111128065323 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 12859 5986 231 K98G Thermonuclease Staphylococcus aureus 0.68 0.7 4.9 1.03 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 27.371111128065323 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13577 5986 231 K98G Thermonuclease Staphylococcus aureus 0.68 0.7 4.7 1.03 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 27.371111128065323 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13332 6244 231 K98F Thermonuclease Staphylococcus aureus 0.79 0.5 5.0 0.96 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 27.371111128065323 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 13000 6089 231 A99G Thermonuclease Staphylococcus aureus 0.9 0.3 5.2 0.86 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 17.077999877929688 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 13001 6090 231 A99V Thermonuclease Staphylococcus aureus 0.51 1.9 3.6 1.05 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 17.077999877929688 1610820 10.1021/bi00140a005 1992 ProTherm SAAFEC_S1262.csv 3444 1792 231 I100M Thermonuclease Staphylococcus aureus 59.8 -2.1 yes 45.7 Unknown NaCl 0.3 M NMR Thermal 5.42 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 19.413749933242798 2372535 10.1021/bi00471a003 1990 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, Broom_S605.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8092 1792 231 I100M Thermonuclease Staphylococcus aureus 0.0 0.2 1.2 yes Unknown 40.0 NaCl 0.3 M NMR Thermal 5.42 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 19.413749933242798 2372535 10.1021/bi00471a003 1990 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 12747 1792 231 I100M Thermonuclease Staphylococcus aureus 0.69 0.7 4.7 6.75 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 19.413749933242798 11705391 10.1021/bi011267t 2001 ProTherm 13301 1792 231 I100M Thermonuclease Staphylococcus aureus 0.5 1.07 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 19.413749933242798 8399139 10.1021/bi00089a032 1993 ProTherm SAAFEC_S983.csv 13314 1792 231 I100M Thermonuclease Staphylococcus aureus 0.68 0.6 5.0 1.07 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 19.413749933242798 3449854 10.1002/prot.340010113 1986 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 13320 1792 231 I100M Thermonuclease Staphylococcus aureus 2.18 0.7 5.4 1.04 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence Urea 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 19.413749933242798 3449854 10.1002/prot.340010113 1986 ProTherm 12746 5903 231 I100L Thermonuclease Staphylococcus aureus 0.81 0.2 5.2 6.45 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 19.413749933242798 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 13123 6189 231 I100G Thermonuclease Staphylococcus aureus -2.6 1.06 yes Na2HPO4 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 19.413749933242798 2381904 10.1002/prot.340070402 1990 ProTherm 13441 6189 231 I100G Thermonuclease Staphylococcus aureus 0.4 2.5 2.98 1.05 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 19.413749933242798 2261461 10.1021/bi00487a007 1990 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13439 6307 231 I100V Thermonuclease Staphylococcus aureus 0.6 1.1 4.38 0.94 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 19.413749933242798 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13440 6308 231 I100A Thermonuclease Staphylococcus aureus 0.3 2.5 2.98 1.12 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 19.413749933242798 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 15512 7204 231 I100M, A172S Thermonuclease Staphylococcus aureus 2.8 2.8 yes Na3PO4 25 mM 20.0 NaCl 0.1 M Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 8.0 1STN 19.413749933242798, 7.815999984741211 in pocket 3167015 10.1021/bi00413a027 1988 ProTherm 15522 7204 231 I100M, A172S Thermonuclease Staphylococcus aureus 2.7 1.16 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 8.0 1STN 19.413749933242798, 7.815999984741211 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15589 7204 231 I100M, A172S Thermonuclease Staphylococcus aureus 0.35 2.8 2.8 1.16 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 8.0 1STN 19.413749933242798, 7.815999984741211 in pocket 3449854 10.1002/prot.340010113 1986 ProTherm 15594 7204 231 I100M, A172S Thermonuclease Staphylococcus aureus 1.2 2.9 3.2 1.12 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence Urea 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 8.0 1STN 19.413749933242798, 7.815999984741211 in pocket 3449854 10.1002/prot.340010113 1986 ProTherm 15520 7212 231 I100M, T115S Thermonuclease Staphylococcus aureus 2.0 1.09 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 7.0 1STN 19.413749933242798, 12.604285648890905 8399139 10.1021/bi00089a032 1993 ProTherm 15521 7213 231 I100M, A151T Thermonuclease Staphylococcus aureus 3.3 1.26 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 6.0 1STN 19.413749933242798, 15.82599983215332 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15588 7213 231 I100M, A151T Thermonuclease Staphylococcus aureus 0.26 3.4 2.2 1.26 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 6.0 1STN 19.413749933242798, 15.82599983215332 in pocket 3449854 10.1002/prot.340010113 1986 ProTherm 15593 7213 231 I100M, A151T Thermonuclease Staphylococcus aureus 0.91 3.8 2.3 1.08 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence Urea 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 6.0 1STN 19.413749933242798, 15.82599983215332 in pocket 3449854 10.1002/prot.340010113 1986 ProTherm 2439 1275 231 D101F Thermonuclease Staphylococcus aureus 99.0 -4.6 Unknown 48.1 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 16.81374990940094 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, Broom_S605.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 2534 1275 231 D101F Thermonuclease Staphylococcus aureus 88.0 -4.5 Unknown 48.5 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 16.81374990940094 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv, Broom_S605.csv 13333 1275 231 D101F Thermonuclease Staphylococcus aureus 0.67 1.5 4.0 0.9 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 16.81374990940094 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv 12812 5944 231 D101A Thermonuclease Staphylococcus aureus 0.79 0.1 5.5 1.0 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 16.81374990940094 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 13572 5944 231 D101A Thermonuclease Staphylococcus aureus 0.79 0.1 5.3 1.0 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 16.81374990940094 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 12813 5945 231 D101G Thermonuclease Staphylococcus aureus 0.74 0.5 5.1 1.0 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 16.81374990940094 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13573 5945 231 D101G Thermonuclease Staphylococcus aureus 0.73 0.3 5.1 1.04 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 16.81374990940094 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm SAAFEC_S983.csv 12918 6043 231 D101K Thermonuclease Staphylococcus aureus 0.74 0.3 5.1 6.93 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 16.81374990940094 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 12919 6044 231 D101N Thermonuclease Staphylococcus aureus 0.87 0.2 5.2 5.94 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 16.81374990940094 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 13036 6124 231 G102A Thermonuclease Staphylococcus aureus 0.81 0.3 5.2 0.94 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 10.09000015258789 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 13037 6125 231 G102V Thermonuclease Staphylococcus aureus 0.5 2.3 3.2 0.93 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 10.09000015258789 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm SAAFEC_S1262.csv 13155 6201 231 G102E Thermonuclease Staphylococcus aureus 1.3 3.2 6.3 4.7 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 3.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 10.09000015258789 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm SAAFEC_S983.csv 13156 6201 231 G102E Thermonuclease Staphylococcus aureus 1.6 3.5 8.2 5.1 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 4.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 10.09000015258789 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13157 6201 231 G102E Thermonuclease Staphylococcus aureus 1.5 3.7 8.0 5.2 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 6.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 10.09000015258789 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm SAAFEC_S1262.csv 13158 6201 231 G102E Thermonuclease Staphylococcus aureus 1.5 4.1 7.8 5.1 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 10.09000015258789 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13159 6201 231 G102E Thermonuclease Staphylococcus aureus 1.5 3.8 7.8 5.2 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 9.1 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 10.09000015258789 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm SAAFEC_S1262.csv 4334 2192 231 D103K Thermonuclease Staphylococcus aureus Unknown 61.2 Sodium phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS binding site 9.0 1STN 13.87625002861023 in tunnel in pocket 11023780 10.1006/jmbi.2000.4140 2000 ProTherm 12920 2192 231 D103K Thermonuclease Staphylococcus aureus 1.02 -1.0 6.4 6.34 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS binding site 9.0 1STN 13.87625002861023 in tunnel in pocket 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv 13619 2192 231 D103K Thermonuclease Staphylococcus aureus 6.4 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS binding site 9.0 1STN 13.87625002861023 in tunnel in pocket 11023780 10.1006/jmbi.2000.4140 2000 ProTherm 4335 2193 231 D103N Thermonuclease Staphylococcus aureus Unknown 60.5 Sodium phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS binding site 9.0 1STN 13.87625002861023 in tunnel in pocket 11023780 10.1006/jmbi.2000.4140 2000 ProTherm 12921 2193 231 D103N Thermonuclease Staphylococcus aureus 1.05 -1.4 6.8 6.47 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS binding site 9.0 1STN 13.87625002861023 in tunnel in pocket 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv 13620 2193 231 D103N Thermonuclease Staphylococcus aureus 6.8 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS binding site 9.0 1STN 13.87625002861023 in tunnel in pocket 11023780 10.1006/jmbi.2000.4140 2000 ProTherm 12814 5946 231 D103A Thermonuclease Staphylococcus aureus 0.94 -0.7 6.3 0.96 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS binding site 9.0 1STN 13.87625002861023 in tunnel in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13570 5946 231 D103A Thermonuclease Staphylococcus aureus 0.94 -0.7 6.1 0.96 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS binding site 9.0 1STN 13.87625002861023 in tunnel in pocket 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12815 5947 231 D103G Thermonuclease Staphylococcus aureus 0.89 -0.3 5.9 0.96 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS binding site 9.0 1STN 13.87625002861023 in tunnel in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 13571 5947 231 D103G Thermonuclease Staphylococcus aureus 0.89 -0.3 5.7 0.96 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS binding site 9.0 1STN 13.87625002861023 in tunnel in pocket 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 2409 1245 231 T104S Thermonuclease Staphylococcus aureus 89.0 -2.8 Unknown 49.9 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 11.005714280264717 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv 2504 1245 231 T104S Thermonuclease Staphylococcus aureus 83.0 -1.5 Unknown 51.5 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 11.005714280264717 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 13511 1245 231 T104S Thermonuclease Staphylococcus aureus 0.7 0.6 5.0 1.06 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 11.005714280264717 in tunnel in pocket 7577991 10.1021/bi00042a029 1995 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 2417 1253 231 T104V Thermonuclease Staphylococcus aureus 76.0 -3.6 Unknown 49.1 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 11.005714280264717 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, HotMuSiC_S1626.csv, AUTOMUTE_S1962.csv, Saraboji_S2204.csv 2512 1253 231 T104V Thermonuclease Staphylococcus aureus 77.0 -1.7 Unknown 51.3 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 11.005714280264717 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm STRUM_Q306.csv, STRUM_Q3421.csv 13519 1253 231 T104V Thermonuclease Staphylococcus aureus 0.71 0.9 4.7 0.99 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 11.005714280264717 in tunnel in pocket 7577991 10.1021/bi00042a029 1995 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 2425 1261 231 T104C Thermonuclease Staphylococcus aureus 74.0 -3.8 Unknown 48.9 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 11.005714280264717 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv 2520 1261 231 T104C Thermonuclease Staphylococcus aureus 79.0 -1.8 Unknown 51.2 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 11.005714280264717 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm Broom_S605.csv, STRUM_Q3421.csv 13527 1261 231 T104C Thermonuclease Staphylococcus aureus 0.68 0.9 4.7 1.02 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 11.005714280264717 in tunnel in pocket 7577991 10.1021/bi00042a029 1995 ProTherm SAAFEC_S1262.csv 2432 1268 231 T104I Thermonuclease Staphylococcus aureus 74.0 -3.0 Unknown 49.7 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 11.005714280264717 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm HotMuSiC_S1626.csv 2527 1268 231 T104I Thermonuclease Staphylococcus aureus 78.0 -3.6 Unknown 49.4 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 11.005714280264717 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm Broom_S605.csv, EASE-MM_S238.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv 12778 1268 231 T104I Thermonuclease Staphylococcus aureus 0.74 0.7 4.7 6.4 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 11.005714280264717 in tunnel in pocket 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv 13085 6169 231 T104G Thermonuclease Staphylococcus aureus 0.41 2.4 3.1 1.1 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 11.005714280264717 in tunnel in pocket 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13086 6170 231 T104A Thermonuclease Staphylococcus aureus 0.54 1.6 3.9 1.07 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 11.005714280264717 in tunnel in pocket 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 2380 1217 231 V105T Thermonuclease Staphylococcus aureus 67.0 -14.7 Unknown 38.0 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 12.74000004359654 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm PoPMuSiC-2.0_S2648.csv, Broom_S605.csv 2475 1217 231 V105T Thermonuclease Staphylococcus aureus 68.0 -14.0 Unknown 39.0 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 12.74000004359654 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm Broom_S605.csv, AUTOMUTE_S1962.csv, Saraboji_S2204.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv 13478 1217 231 V105T Thermonuclease Staphylococcus aureus 0.31 3.2 2.4 1.17 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 12.74000004359654 in pocket 7577991 10.1021/bi00042a029 1995 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 3005 1602 231 V105A Thermonuclease Staphylococcus aureus -12.5 yes 41.6 Sodium phosphate 20 mM NaCl 100 mM DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 12.74000004359654 in pocket 7849061 10.1021/bi00006a025 1995 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 11078 1602 231 V105A Thermonuclease Staphylococcus aureus 1.7 8.2 Unknown Sodium acetate 50 mM 25.0 NaCl 100 mM Fluorescence GdnHCl 5.6 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 12.74000004359654 in pocket 10467101 10.1038/12338 1999 ProTherm 11079 1602 231 V105A Thermonuclease Staphylococcus aureus 2.2 7.7 Unknown Sodium acetate 50 mM 25.0 NaCl 100 mM Fluorescence GdnHCl 5.2 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 12.74000004359654 in pocket 10467101 10.1038/12338 1999 ProTherm 13421 1602 231 V105A Thermonuclease Staphylococcus aureus 0.3 2.9 2.58 1.18 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 12.74000004359654 in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13544 1602 231 V105A Thermonuclease Staphylococcus aureus 2.6 8.1 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 12.74000004359654 in pocket 10467101 10.1038/12338 1999 ProTherm 3442 1790 231 V105F Thermonuclease Staphylococcus aureus 28.7 -10.2 yes 37.6 Unknown NaCl 0.3 M NMR Thermal 5.35 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 12.74000004359654 in pocket 2372535 10.1021/bi00471a003 1990 ProTherm Broom_S605.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S499.csv, AUTOMUTE_S1962.csv, Saraboji_S2204.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 13293 1790 231 V105F Thermonuclease Staphylococcus aureus 2.3 0.84 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 12.74000004359654 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm SAAFEC_S1262.csv 12726 5884 231 V105I Thermonuclease Staphylococcus aureus 0.86 0.2 5.2 6.08 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 12.74000004359654 in pocket 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 12727 5885 231 V105L Thermonuclease Staphylococcus aureus 0.83 0.1 5.3 6.39 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 12.74000004359654 in pocket 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 13160 6202 231 V105E Thermonuclease Staphylococcus aureus 1.0 4.4 5.0 5.0 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 3.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 12.74000004359654 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13161 6202 231 V105E Thermonuclease Staphylococcus aureus 1.2 5.1 6.7 5.7 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 12.74000004359654 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13162 6202 231 V105E Thermonuclease Staphylococcus aureus 1.0 6.0 5.7 5.6 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 6.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 12.74000004359654 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13163 6202 231 V105E Thermonuclease Staphylococcus aureus 0.7 7.5 4.4 5.9 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 12.74000004359654 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13164 6202 231 V105E Thermonuclease Staphylococcus aureus 0.7 7.5 0.0 6.0 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 9.1 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 12.74000004359654 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13487 6335 231 V105S Thermonuclease Staphylococcus aureus 0.11 4.7 0.9 1.3 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 12.74000004359654 in pocket 7577991 10.1021/bi00042a029 1995 ProTherm SAAFEC_S1262.csv 15529 7220 231 V105F, L119A Thermonuclease Staphylococcus aureus 3.17 0.73 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 9.0 1STN 12.74000004359654, 12.043750047683716 in tunnel in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15530 7221 231 V105F, E157V Thermonuclease Staphylococcus aureus 4.79 0.58 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 8.0 1STN 12.74000004359654, 12.881110933091906 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15531 7222 231 V105F, G161S Thermonuclease Staphylococcus aureus 4.75 0.59 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 6.0 1STN 12.74000004359654, 12.882500171661377 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15545 7235 231 V105F, T115S Thermonuclease Staphylococcus aureus 2.72 1.03 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0 1STN 12.74000004359654, 12.604285648890905 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15546 7236 231 V105F, A151T Thermonuclease Staphylococcus aureus 4.0 1.17 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 6.0 1STN 12.74000004359654, 15.82599983215332 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15547 7237 231 V105F, A172S Thermonuclease Staphylococcus aureus 3.31 1.06 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 8.0 1STN 12.74000004359654, 7.815999984741211 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15562 7252 231 V105F, I154V Thermonuclease Staphylococcus aureus 2.9 0.95 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 8.0 1STN 12.74000004359654, 10.5625 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15563 7253 231 V105F, Y167A Thermonuclease Staphylococcus aureus 2.51 0.86 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 9.0 1STN 12.74000004359654, 18.133333285649616 in tunnel in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15564 7254 231 V105F, I174V Thermonuclease Staphylococcus aureus 2.01 0.96 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 8.0 1STN 12.74000004359654, 9.303750038146973 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15565 7255 231 V105F, Y195A Thermonuclease Staphylococcus aureus 1.89 0.91 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 9.0 1STN 12.74000004359654, 33.795000076293945 in tunnel in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15566 7256 231 V105F, A212G Thermonuclease Staphylococcus aureus 3.5 0.76 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 4.0 1STN 12.74000004359654, 13.848000144958496 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 17149 7997 231 V105I, L107I, V148I Thermonuclease Staphylococcus aureus 0.43 2.9 2.5 5.68 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0, 8.0 1STN 12.74000004359654, 11.639999985694885, 13.088571275983538 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17150 7998 231 V105I, L107I, V148L Thermonuclease Staphylococcus aureus 0.56 2.5 2.9 5.16 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0, 8.0 1STN 12.74000004359654, 11.639999985694885, 13.088571275983538 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17151 7999 231 V105I, L107V, V148I Thermonuclease Staphylococcus aureus 0.46 2.7 2.7 5.81 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0, 8.0 1STN 12.74000004359654, 11.639999985694885, 13.088571275983538 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17152 8000 231 V105I, L107V, V148L Thermonuclease Staphylococcus aureus 0.6 2.1 3.3 5.49 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0, 8.0 1STN 12.74000004359654, 11.639999985694885, 13.088571275983538 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17153 8001 231 V105L, L107V, V148L Thermonuclease Staphylococcus aureus 0.56 2.0 3.4 6.14 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0, 8.0 1STN 12.74000004359654, 11.639999985694885, 13.088571275983538 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17154 8002 231 V105L, L107V, V148I Thermonuclease Staphylococcus aureus 0.4 2.8 2.6 6.46 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0, 8.0 1STN 12.74000004359654, 11.639999985694885, 13.088571275983538 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17155 8003 231 V105L, L107I, V148I Thermonuclease Staphylococcus aureus 0.4 3.1 2.3 5.88 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0, 8.0 1STN 12.74000004359654, 11.639999985694885, 13.088571275983538 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17156 8004 231 V105L, L107I, V148L Thermonuclease Staphylococcus aureus 0.51 2.4 3.0 5.81 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0, 8.0 1STN 12.74000004359654, 11.639999985694885, 13.088571275983538 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17157 8005 231 V105I, L107I, I154V Thermonuclease Staphylococcus aureus 0.38 2.8 2.6 6.86 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0, 8.0 1STN 12.74000004359654, 11.639999985694885, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17158 8006 231 V105I, L107I, I154L Thermonuclease Staphylococcus aureus 0.6 1.7 3.7 6.2 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0, 8.0 1STN 12.74000004359654, 11.639999985694885, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17159 8007 231 V105I, L107V, I154V Thermonuclease Staphylococcus aureus 0.44 2.3 3.1 7.05 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0, 8.0 1STN 12.74000004359654, 11.639999985694885, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17160 8008 231 V105I, L107V, I154L Thermonuclease Staphylococcus aureus 0.67 1.1 4.3 6.53 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0, 8.0 1STN 12.74000004359654, 11.639999985694885, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17161 8009 231 V105L, L107V, I154V Thermonuclease Staphylococcus aureus 0.35 2.8 2.6 7.51 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0, 8.0 1STN 12.74000004359654, 11.639999985694885, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17162 8010 231 V105L, L107V, I154L Thermonuclease Staphylococcus aureus 0.57 1.5 3.9 6.86 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0, 8.0 1STN 12.74000004359654, 11.639999985694885, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17163 8011 231 V105L, L107I, I154V Thermonuclease Staphylococcus aureus 0.41 2.5 2.9 7.05 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0, 8.0 1STN 12.74000004359654, 11.639999985694885, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17164 8012 231 V105L, L107I, I154L Thermonuclease Staphylococcus aureus 0.6 1.4 4.0 6.79 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0, 8.0 1STN 12.74000004359654, 11.639999985694885, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17181 8029 231 V105I, V148I, I154L Thermonuclease Staphylococcus aureus 0.62 2.0 3.4 5.42 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 8.0, 8.0 1STN 12.74000004359654, 13.088571275983538, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17182 8030 231 V105I, V148I, I154V Thermonuclease Staphylococcus aureus 0.63 1.6 3.8 6.07 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 8.0, 8.0 1STN 12.74000004359654, 13.088571275983538, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17183 8031 231 V105I, V148L, I154L Thermonuclease Staphylococcus aureus 0.69 1.4 4.0 5.75 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 8.0, 8.0 1STN 12.74000004359654, 13.088571275983538, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17184 8032 231 V105I, V148L, I154V Thermonuclease Staphylococcus aureus 0.76 0.9 4.5 5.88 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 8.0, 8.0 1STN 12.74000004359654, 13.088571275983538, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17185 8033 231 V105L, V148I, I154L Thermonuclease Staphylococcus aureus 0.58 2.0 3.4 5.94 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 8.0, 8.0 1STN 12.74000004359654, 13.088571275983538, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17186 8034 231 V105L, V148I, I154V Thermonuclease Staphylococcus aureus 0.57 1.6 3.8 6.53 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 8.0, 8.0 1STN 12.74000004359654, 13.088571275983538, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17187 8035 231 V105L, V148L, I154L Thermonuclease Staphylococcus aureus 0.65 1.3 4.1 6.27 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 8.0, 8.0 1STN 12.74000004359654, 13.088571275983538, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17188 8036 231 V105L, V148L, I154V Thermonuclease Staphylococcus aureus 0.64 1.3 4.1 6.46 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 8.0, 8.0 1STN 12.74000004359654, 13.088571275983538, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17213 8061 231 V105I, L107I, V148I, I154V Thermonuclease Staphylococcus aureus 0.35 3.2 2.2 6.14 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0, 8.0, 8.0 1STN 12.74000004359654, 11.639999985694885, 13.088571275983538, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17214 8062 231 V105I, L107I, V148I, I154L Thermonuclease Staphylococcus aureus 0.4 3.2 2.2 5.55 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0, 8.0, 8.0 1STN 12.74000004359654, 11.639999985694885, 13.088571275983538, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17215 8063 231 V105I, L107I, V148L, I154L Thermonuclease Staphylococcus aureus 0.47 2.7 2.7 5.75 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0, 8.0, 8.0 1STN 12.74000004359654, 11.639999985694885, 13.088571275983538, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17216 8064 231 V105I, L107I, V148L, I154V Thermonuclease Staphylococcus aureus 0.48 2.6 2.8 5.88 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0, 8.0, 8.0 1STN 12.74000004359654, 11.639999985694885, 13.088571275983538, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17217 8065 231 V105I, L107V, V148I, I154V Thermonuclease Staphylococcus aureus 0.37 3.0 2.4 6.4 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0, 8.0, 8.0 1STN 12.74000004359654, 11.639999985694885, 13.088571275983538, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17218 8066 231 V105I, L107V, V148I, I154L Thermonuclease Staphylococcus aureus 0.45 2.8 2.6 6.4 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0, 8.0, 8.0 1STN 12.74000004359654, 11.639999985694885, 13.088571275983538, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17219 8067 231 V105I, L107V, V148L, I154L Thermonuclease Staphylococcus aureus 0.49 2.5 2.9 5.94 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0, 8.0, 8.0 1STN 12.74000004359654, 11.639999985694885, 13.088571275983538, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17220 8068 231 V105I, L107V, V148L, I154V Thermonuclease Staphylococcus aureus 0.52 2.1 3.3 6.33 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0, 8.0, 8.0 1STN 12.74000004359654, 11.639999985694885, 13.088571275983538, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17221 8069 231 V105L, L107I, V148I, I154V Thermonuclease Staphylococcus aureus 0.32 3.4 2.0 6.4 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0, 8.0, 8.0 1STN 12.74000004359654, 11.639999985694885, 13.088571275983538, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17222 8070 231 V105L, L107I, V148I, I154L Thermonuclease Staphylococcus aureus 0.37 3.2 2.2 5.88 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0, 8.0, 8.0 1STN 12.74000004359654, 11.639999985694885, 13.088571275983538, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17223 8071 231 V105L, L107I, V148L, I154L Thermonuclease Staphylococcus aureus 0.48 2.4 3.0 6.27 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0, 8.0, 8.0 1STN 12.74000004359654, 11.639999985694885, 13.088571275983538, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17224 8072 231 V105L, L107I, V148L, I154V Thermonuclease Staphylococcus aureus 0.41 2.6 2.8 6.73 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0, 8.0, 8.0 1STN 12.74000004359654, 11.639999985694885, 13.088571275983538, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17225 8073 231 V105L, L107V, V148I, I154V Thermonuclease Staphylococcus aureus 0.28 3.4 2.0 7.05 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0, 8.0, 8.0 1STN 12.74000004359654, 11.639999985694885, 13.088571275983538, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17226 8074 231 V105L, L107V, V148I, I154L Thermonuclease Staphylococcus aureus 0.41 2.8 2.6 6.2 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0, 8.0, 8.0 1STN 12.74000004359654, 11.639999985694885, 13.088571275983538, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17227 8075 231 V105L, L107V, V148L, I154L Thermonuclease Staphylococcus aureus 0.52 2.0 3.4 6.53 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0, 8.0, 8.0 1STN 12.74000004359654, 11.639999985694885, 13.088571275983538, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17228 8076 231 V105L, L107V, V148L, I154V Thermonuclease Staphylococcus aureus 0.42 2.5 2.9 6.79 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0, 8.0, 8.0 1STN 12.74000004359654, 11.639999985694885, 13.088571275983538, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17245 8093 231 V105I, L107V, I154V, I174V Thermonuclease Staphylococcus aureus 0.41 2.4 3.0 7.18 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0, 8.0, 8.0 1STN 12.74000004359654, 11.639999985694885, 10.5625, 9.303750038146973 in pocket 11735410 10.1021/bi011776v 2001 ProTherm 17246 8094 231 V105I, L107V, V148L, I154V, I174V Thermonuclease Staphylococcus aureus 0.53 1.9 3.5 6.53 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0, 8.0, 8.0, 8.0 1STN 12.74000004359654, 11.639999985694885, 13.088571275983538, 10.5625, 9.303750038146973 in pocket 11735410 10.1021/bi011776v 2001 ProTherm 17247 8095 231 V105I, V148L, I154V, I174V Thermonuclease Staphylococcus aureus 0.74 0.6 4.8 6.53 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 8.0, 8.0, 8.0 1STN 12.74000004359654, 13.088571275983538, 10.5625, 9.303750038146973 in pocket 11735410 10.1021/bi011776v 2001 ProTherm 17248 8096 231 V105I, L107V, I154V, I174V, V181L Thermonuclease Staphylococcus aureus 0.33 3.0 2.4 7.25 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0, 8.0, 8.0, 7.0 1STN 12.74000004359654, 11.639999985694885, 10.5625, 9.303750038146973, 6.662857123783657 in pocket 11735410 10.1021/bi011776v 2001 ProTherm 17249 8097 231 V105I, L107V, I154V, I174V, V181I Thermonuclease Staphylococcus aureus 0.39 2.7 2.7 7.05 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0, 8.0, 8.0, 7.0 1STN 12.74000004359654, 11.639999985694885, 10.5625, 9.303750038146973, 6.662857123783657 in pocket 11735410 10.1021/bi011776v 2001 ProTherm 17250 8098 231 V105I, L107I, V148L, I154V, I174V Thermonuclease Staphylococcus aureus 0.47 2.3 3.1 6.53 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0, 8.0, 8.0, 8.0 1STN 12.74000004359654, 11.639999985694885, 13.088571275983538, 10.5625, 9.303750038146973 in pocket 11735410 10.1021/bi011776v 2001 ProTherm 17251 8099 231 V105L, L107V, V148L, I154V, I174V Thermonuclease Staphylococcus aureus 0.45 2.2 3.2 7.12 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0, 8.0, 8.0, 8.0 1STN 12.74000004359654, 11.639999985694885, 13.088571275983538, 10.5625, 9.303750038146973 in pocket 11735410 10.1021/bi011776v 2001 ProTherm 17252 8100 231 V105I, L107I Thermonuclease Staphylococcus aureus 0.6 1.7 3.7 0.93 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0 1STN 12.74000004359654, 11.639999985694885 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 17253 8101 231 V105I, L107V Thermonuclease Staphylococcus aureus 0.63 1.4 4.0 0.95 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0 1STN 12.74000004359654, 11.639999985694885 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 17254 8102 231 V105L, L107I Thermonuclease Staphylococcus aureus 0.6 1.5 3.9 0.97 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0 1STN 12.74000004359654, 11.639999985694885 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 17255 8103 231 V105L, L107V Thermonuclease Staphylococcus aureus 0.53 1.8 3.6 1.01 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0 1STN 12.74000004359654, 11.639999985694885 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 17264 8112 231 V105I, V148I Thermonuclease Staphylococcus aureus 0.75 1.5 3.9 0.78 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 8.0 1STN 12.74000004359654, 13.088571275983538 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 17265 8113 231 V105I, V148L Thermonuclease Staphylococcus aureus 0.89 1.0 4.4 0.74 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 8.0 1STN 12.74000004359654, 13.088571275983538 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 17266 8114 231 V105L, V148I Thermonuclease Staphylococcus aureus 0.67 1.5 3.9 0.86 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 8.0 1STN 12.74000004359654, 13.088571275983538 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 17267 8115 231 V105L, V148L Thermonuclease Staphylococcus aureus 0.78 1.1 4.3 0.83 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 8.0 1STN 12.74000004359654, 13.088571275983538 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 17272 8120 231 V105I, I154L Thermonuclease Staphylococcus aureus 0.8 0.5 4.9 0.91 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 8.0 1STN 12.74000004359654, 10.5625 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 17273 8121 231 V105I, I154V Thermonuclease Staphylococcus aureus 0.64 1.1 4.3 1.01 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 8.0 1STN 12.74000004359654, 10.5625 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 17274 8122 231 V105L, I154L Thermonuclease Staphylococcus aureus 0.79 0.4 5.0 0.95 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 8.0 1STN 12.74000004359654, 10.5625 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 17275 8123 231 V105L, I154V Thermonuclease Staphylococcus aureus 0.62 1.1 4.3 1.04 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 8.0 1STN 12.74000004359654, 10.5625 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 3006 1603 231 K106G Thermonuclease Staphylococcus aureus -6.3 yes 47.9 Sodium phosphate 20 mM NaCl 100 mM DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 23.723333676656086 7849061 10.1021/bi00006a025 1995 ProTherm Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1962.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 12861 1603 231 K106G Thermonuclease Staphylococcus aureus 0.51 1.2 4.4 1.23 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 23.723333676656086 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12860 5987 231 K106A Thermonuclease Staphylococcus aureus 0.73 0.2 5.4 1.06 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 23.723333676656086 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 13334 6245 231 K106F Thermonuclease Staphylococcus aureus 0.8 0.6 4.9 0.93 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 23.723333676656086 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 213 107 231 L107A Thermonuclease Staphylococcus aureus 2.5 90.0 -11.5 yes 39.9 phosphate 0.05 M NaCl 0.1 M DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 11.639999985694885 in pocket 8518730 10.1002/pro.5560020408 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 219 107 231 L107A Thermonuclease Staphylococcus aureus 2.5 63.0 -15.8 yes 31.2 phosphate 0.05 M NaCl 0.1 M DSC Thermal 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 11.639999985694885 in pocket 8518730 10.1002/pro.5560020408 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7603 107 231 L107A Thermonuclease Staphylococcus aureus 2.5 2.6 yes phosphate 0.05 M 51.4 NaCl 0.1 M DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 11.639999985694885 in pocket 8518730 10.1002/pro.5560020408 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 7790 107 231 L107A Thermonuclease Staphylococcus aureus 2.5 2.8 yes phosphate 0.05 M 47.0 NaCl 0.1 M DSC Thermal 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 11.639999985694885 in pocket 8518730 10.1002/pro.5560020408 1993 ProTherm capriotti_S1615_map.csv 13407 107 231 L107A Thermonuclease Staphylococcus aureus 0.3 2.7 2.78 1.12 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 11.639999985694885 in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12759 5915 231 L107I Thermonuclease Staphylococcus aureus 0.52 1.7 3.7 7.05 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 11.639999985694885 in pocket 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv 12760 5916 231 L107V Thermonuclease Staphylococcus aureus 0.53 1.8 3.6 6.89 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 11.639999985694885 in pocket 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv 13165 6203 231 L107E Thermonuclease Staphylococcus aureus 0.7 5.9 3.5 5.0 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 3.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 11.639999985694885 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13166 6203 231 L107E Thermonuclease Staphylococcus aureus 0.9 6.4 5.4 5.8 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 11.639999985694885 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13167 6203 231 L107E Thermonuclease Staphylococcus aureus 0.8 7.6 4.1 5.5 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 6.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 11.639999985694885 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13168 6203 231 L107E Thermonuclease Staphylococcus aureus 0.5 9.8 2.1 4.3 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 8.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 11.639999985694885 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13169 6203 231 L107E Thermonuclease Staphylococcus aureus 0.5 9.5 2.1 4.4 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 9.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 11.639999985694885 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13408 6285 231 L107G Thermonuclease Staphylococcus aureus 0.1 4.5 0.98 1.18 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 11.639999985694885 in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 15502 7197 231 L107A, M108A Thermonuclease Staphylococcus aureus 4.4 1.2 Unknown NaH2PO4 10 mM 20.0 NaCl 100 mM CD GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 3.0 1STN 11.639999985694885, 22.941250324249268 in pocket 1620695 10.1002/prot.340130206 1992 ProTherm 17189 8037 231 L107I, V148I, I154L Thermonuclease Staphylococcus aureus 0.38 3.0 2.4 6.33 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 8.0, 8.0 1STN 11.639999985694885, 13.088571275983538, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17190 8038 231 L107I, V148I, I154V Thermonuclease Staphylococcus aureus 0.32 3.2 2.2 6.99 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 8.0, 8.0 1STN 11.639999985694885, 13.088571275983538, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17191 8039 231 L107I, V148L, I154L Thermonuclease Staphylococcus aureus 0.49 2.3 3.1 6.2 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 8.0, 8.0 1STN 11.639999985694885, 13.088571275983538, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17192 8040 231 L107I, V148L, I154V Thermonuclease Staphylococcus aureus 0.51 2.2 3.2 6.4 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 8.0, 8.0 1STN 11.639999985694885, 13.088571275983538, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17193 8041 231 L107V, V148I, I154L Thermonuclease Staphylococcus aureus 0.4 3.0 2.4 6.07 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 8.0, 8.0 1STN 11.639999985694885, 13.088571275983538, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17194 8042 231 L107V, V148I, I154V Thermonuclease Staphylococcus aureus 0.32 3.1 2.3 7.12 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 8.0, 8.0 1STN 11.639999985694885, 13.088571275983538, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17195 8043 231 L107V, V148L, I154L Thermonuclease Staphylococcus aureus 0.51 2.2 3.2 6.33 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 8.0, 8.0 1STN 11.639999985694885, 13.088571275983538, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17196 8044 231 L107V, V148L, I154V Thermonuclease Staphylococcus aureus 0.51 2.0 3.4 6.66 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 8.0, 8.0 1STN 11.639999985694885, 13.088571275983538, 10.5625 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17268 8116 231 L107I, V148I Thermonuclease Staphylococcus aureus 0.38 3.0 2.4 0.92 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 8.0 1STN 11.639999985694885, 13.088571275983538 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 17269 8117 231 L107I, V148L Thermonuclease Staphylococcus aureus 0.6 1.9 3.5 0.88 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 8.0 1STN 11.639999985694885, 13.088571275983538 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 17270 8118 231 L107V, V148I Thermonuclease Staphylococcus aureus 0.4 2.9 2.5 0.94 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 8.0 1STN 11.639999985694885, 13.088571275983538 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 17271 8119 231 L107V, V148L Thermonuclease Staphylococcus aureus 0.6 1.8 3.6 0.89 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 8.0 1STN 11.639999985694885, 13.088571275983538 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 17276 8124 231 L107I, I154L Thermonuclease Staphylococcus aureus 0.53 1.7 3.7 1.06 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 8.0 1STN 11.639999985694885, 10.5625 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 17277 8125 231 L107I, I154V Thermonuclease Staphylococcus aureus 0.32 3.0 2.4 1.09 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 8.0 1STN 11.639999985694885, 10.5625 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 17278 8126 231 L107V, I154L Thermonuclease Staphylococcus aureus 0.56 1.6 3.8 1.03 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 8.0 1STN 11.639999985694885, 10.5625 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 17279 8127 231 L107V, I154V Thermonuclease Staphylococcus aureus 0.35 2.9 2.5 1.09 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 8.0 1STN 11.639999985694885, 10.5625 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 11076 4694 231 M108G Thermonuclease Staphylococcus aureus 2.5 7.9 Unknown Sodium acetate 50 mM 25.0 NaCl 100 mM Fluorescence GdnHCl 5.6 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 22.941250324249268 in pocket 10467101 10.1038/12338 1999 ProTherm 11077 4694 231 M108G Thermonuclease Staphylococcus aureus 3.1 7.4 Unknown Sodium acetate 50 mM 25.0 NaCl 100 mM Fluorescence GdnHCl 5.2 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 22.941250324249268 in pocket 10467101 10.1038/12338 1999 ProTherm 13450 4694 231 M108G Thermonuclease Staphylococcus aureus 0.4 2.2 3.28 1.11 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 22.941250324249268 in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13543 4694 231 M108G Thermonuclease Staphylococcus aureus 3.3 7.6 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 22.941250324249268 in pocket 10467101 10.1038/12338 1999 ProTherm 12721 5879 231 M108I Thermonuclease Staphylococcus aureus 0.7 0.9 4.5 0.99 Unknown sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 22.941250324249268 in pocket 11438757 10.1093/protein/14.5.343 2001 ProTherm SAAFEC_S1262.csv 12724 5882 231 M108L Thermonuclease Staphylococcus aureus 0.8 0.5 4.9 0.93 Unknown sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 22.941250324249268 in pocket 11438757 10.1093/protein/14.5.343 2001 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 13449 6315 231 M108A Thermonuclease Staphylococcus aureus 0.5 1.5 3.98 1.07 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 22.941250324249268 in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 2393 1230 231 Y109F Thermonuclease Staphylococcus aureus 82.0 -3.9 Unknown 48.8 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 18.977500041325886 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv 2488 1230 231 Y109F Thermonuclease Staphylococcus aureus 82.0 -2.0 Unknown 51.0 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 18.977500041325886 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv 13280 1230 231 Y109F Thermonuclease Staphylococcus aureus 0.77 0.0 5.0 1.1 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 18.977500041325886 in pocket 9315853 10.1021/bi970876r 1997 ProTherm 13496 1230 231 Y109F Thermonuclease Staphylococcus aureus 0.74 0.6 5.0 1.01 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 18.977500041325886 in pocket 7577991 10.1021/bi00042a029 1995 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv 13277 6225 231 Y109A Thermonuclease Staphylococcus aureus 0.29 2.8 2.2 1.07 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 18.977500041325886 in pocket 9315853 10.1021/bi970876r 1997 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv 13457 6225 231 Y109A Thermonuclease Staphylococcus aureus 0.1 4.2 1.28 1.1 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 18.977500041325886 in pocket 2261461 10.1021/bi00487a007 1990 ProTherm 13278 6226 231 Y109C Thermonuclease Staphylococcus aureus 0.41 2.9 2.1 1.02 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 18.977500041325886 in pocket 9315853 10.1021/bi970876r 1997 ProTherm SAAFEC_S1262.csv 13279 6227 231 Y109E Thermonuclease Staphylococcus aureus 5.0 0.0 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 18.977500041325886 in pocket 9315853 10.1021/bi970876r 1997 ProTherm SAAFEC_S1262.csv 13281 6228 231 Y109H Thermonuclease Staphylococcus aureus 0.48 1.6 3.4 1.19 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 18.977500041325886 in pocket 9315853 10.1021/bi970876r 1997 ProTherm SAAFEC_S1262.csv 13282 6229 231 Y109I Thermonuclease Staphylococcus aureus 0.49 2.5 2.5 0.81 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 18.977500041325886 in pocket 9315853 10.1021/bi970876r 1997 ProTherm SAAFEC_S1262.csv 13283 6230 231 Y109K Thermonuclease Staphylococcus aureus 0.22 3.9 1.1 1.07 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 18.977500041325886 in pocket 9315853 10.1021/bi970876r 1997 ProTherm SAAFEC_S1262.csv 13284 6231 231 Y109L Thermonuclease Staphylococcus aureus 0.57 1.5 3.5 1.07 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 18.977500041325886 in pocket 9315853 10.1021/bi970876r 1997 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13503 6231 231 Y109L Thermonuclease Staphylococcus aureus <-3 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 18.977500041325886 in pocket 7577991 10.1021/bi00042a029 1995 ProTherm 13285 6232 231 Y109M Thermonuclease Staphylococcus aureus 0.52 2.0 3.0 0.98 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 18.977500041325886 in pocket 9315853 10.1021/bi970876r 1997 ProTherm SAAFEC_S1262.csv 13286 6233 231 Y109N Thermonuclease Staphylococcus aureus 0.22 4.0 1.0 1.15 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 18.977500041325886 in pocket 9315853 10.1021/bi970876r 1997 ProTherm SAAFEC_S1262.csv 13287 6234 231 Y109Q Thermonuclease Staphylococcus aureus 0.26 3.2 1.8 1.27 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 18.977500041325886 in pocket 9315853 10.1021/bi970876r 1997 ProTherm SAAFEC_S1262.csv 13288 6235 231 Y109R Thermonuclease Staphylococcus aureus 0.3 2.9 2.1 1.29 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 18.977500041325886 in pocket 9315853 10.1021/bi970876r 1997 ProTherm SAAFEC_S1262.csv 13289 6236 231 Y109S Thermonuclease Staphylococcus aureus 0.26 3.0 2.0 1.32 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 18.977500041325886 in pocket 9315853 10.1021/bi970876r 1997 ProTherm SAAFEC_S1262.csv 13290 6237 231 Y109T Thermonuclease Staphylococcus aureus 0.32 3.3 1.7 1.07 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 18.977500041325886 in pocket 9315853 10.1021/bi970876r 1997 ProTherm SAAFEC_S1262.csv 13291 6238 231 Y109V Thermonuclease Staphylococcus aureus 0.45 3.0 2.0 0.76 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 18.977500041325886 in pocket 9315853 10.1021/bi970876r 1997 ProTherm SAAFEC_S1262.csv 13292 6239 231 Y109W Thermonuclease Staphylococcus aureus 0.7 0.6 4.4 1.08 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 18.977500041325886 in pocket 9315853 10.1021/bi970876r 1997 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 2440 1276 231 K110F Thermonuclease Staphylococcus aureus 91.0 -4.2 Unknown 48.5 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 35.44000011020236 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, EASE-MM_S543.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv, Broom_S605.csv, Saraboji_S2204.csv 2535 1276 231 K110F Thermonuclease Staphylococcus aureus 81.0 -4.2 Unknown 48.8 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 35.44000011020236 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv 13335 1276 231 K110F Thermonuclease Staphylococcus aureus 0.71 0.9 4.6 0.99 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 35.44000011020236 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv 12862 5988 231 K110A Thermonuclease Staphylococcus aureus 0.7 0.7 4.9 1.02 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 35.44000011020236 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13554 5988 231 K110A Thermonuclease Staphylococcus aureus 0.7 0.7 4.7 1.02 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 35.44000011020236 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12863 5989 231 K110G Thermonuclease Staphylococcus aureus 0.67 0.7 4.9 1.04 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 35.44000011020236 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13555 5989 231 K110G Thermonuclease Staphylococcus aureus 0.67 0.7 4.7 1.04 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 35.44000011020236 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12922 6045 231 K110E Thermonuclease Staphylococcus aureus 0.7 0.8 4.6 6.53 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 35.44000011020236 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv 12923 6046 231 K110Q Thermonuclease Staphylococcus aureus 0.78 0.3 5.1 6.53 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 35.44000011020236 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 2441 1277 231 G111F Thermonuclease Staphylococcus aureus 87.0 -6.4 Unknown 46.3 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 26.380000114440918 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 2536 1277 231 G111F Thermonuclease Staphylococcus aureus 82.0 -5.7 Unknown 47.3 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 26.380000114440918 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv, Broom_S605.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4262 1277 231 G111F Thermonuclease Staphylococcus aureus -5.7 yes 47.3 Sodium phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 26.380000114440918 8580845 10.1002/pro.5560041211 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 13336 1277 231 G111F Thermonuclease Staphylococcus aureus 0.57 1.4 4.1 1.09 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 26.380000114440918 9578580 10.1021/bi9725069 1998 ProTherm 13611 1277 231 G111F Thermonuclease Staphylococcus aureus 0.59 1.1 4.4 7.43 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 26.380000114440918 8580845 10.1002/pro.5560041211 1995 ProTherm SAAFEC_S983.csv 4253 2160 231 G111C Thermonuclease Staphylococcus aureus -4.6 yes 48.4 Sodium phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 26.380000114440918 8580845 10.1002/pro.5560041211 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 13602 2160 231 G111C Thermonuclease Staphylococcus aureus 0.62 1.1 4.4 7.09 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 26.380000114440918 8580845 10.1002/pro.5560041211 1995 ProTherm SAAFEC_S1262.csv 13038 6126 231 G111A Thermonuclease Staphylococcus aureus 0.57 1.3 4.2 1.09 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 26.380000114440918 1610820 10.1021/bi00140a005 1992 ProTherm SAAFEC_S1262.csv 13561 6126 231 G111A Thermonuclease Staphylococcus aureus 0.57 1.2 4.2 1.09 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 26.380000114440918 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm SAAFEC_S1262.csv 13039 6127 231 G111V Thermonuclease Staphylococcus aureus 0.33 3.0 2.5 1.11 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 26.380000114440918 1610820 10.1021/bi00140a005 1992 ProTherm SAAFEC_S1262.csv 13064 6151 231 Q112G Thermonuclease Staphylococcus aureus 0.66 0.9 4.6 1.01 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 45.90777778625488 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13065 6152 231 Q112A Thermonuclease Staphylococcus aureus 0.77 0.3 5.2 0.99 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 45.90777778625488 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 13026 6115 231 P113G Thermonuclease Staphylococcus aureus 0.59 1.6 3.9 0.98 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 22.568571090698242 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13027 6116 231 P113A Thermonuclease Staphylococcus aureus 0.77 0.5 5.0 0.95 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 22.568571090698242 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 14399 6116 231 P113A Thermonuclease Staphylococcus aureus 0.2 0.6 4.0 12.0 yes cacodylate 10 mM 0.0 Fluorescence GdnSCN 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 22.568571090698242 8448112 10.1021/bi00061a010 1993 ProTherm SAAFEC_S1262.csv 4123 2096 231 M114L Thermonuclease Staphylococcus aureus 81.0 -3.2 yes 50.3 NaOH 25 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 25.831249952316284 in pocket 8648619 10.1006/jmbi.1996.0180 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 13545 2096 231 M114L Thermonuclease Staphylococcus aureus 0.72 0.8 4.7 6.47 yes NaOH 25 mM 20.0 Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 25.831249952316284 in pocket 8648619 10.1006/jmbi.1996.0180 1996 ProTherm SAAFEC_S1262.csv 4124 2097 231 M114I Thermonuclease Staphylococcus aureus 87.0 -2.3 yes 51.2 NaOH 25 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 25.831249952316284 in pocket 8648619 10.1006/jmbi.1996.0180 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 13546 2097 231 M114I Thermonuclease Staphylococcus aureus 0.75 0.6 4.9 6.57 yes NaOH 25 mM 20.0 Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 25.831249952316284 in pocket 8648619 10.1006/jmbi.1996.0180 1996 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 13451 6316 231 M114A Thermonuclease Staphylococcus aureus 0.5 1.7 3.78 1.06 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 25.831249952316284 in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13452 6317 231 M114G Thermonuclease Staphylococcus aureus 0.4 2.4 3.08 1.09 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 25.831249952316284 in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 15503 7198 231 M114A, T115A Thermonuclease Staphylococcus aureus 3.3 1.13 Unknown NaH2PO4 10 mM 20.0 NaCl 100 mM CD GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0, 7.0 1STN 25.831249952316284, 12.604285648890905 in pocket 1620695 10.1002/prot.340130206 1992 ProTherm 2410 1246 231 T115S Thermonuclease Staphylococcus aureus 85.0 -5.5 Unknown 47.2 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.604285648890905 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 2505 1246 231 T115S Thermonuclease Staphylococcus aureus 80.0 -4.1 Unknown 48.9 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.604285648890905 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 13124 1246 231 T115S Thermonuclease Staphylococcus aureus -1.4 1.07 yes Na2HPO4 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.604285648890905 2381904 10.1002/prot.340070402 1990 ProTherm 13302 1246 231 T115S Thermonuclease Staphylococcus aureus 1.0 1.09 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.604285648890905 8399139 10.1021/bi00089a032 1993 ProTherm SAAFEC_S983.csv 13512 1246 231 T115S Thermonuclease Staphylococcus aureus 0.62 1.3 4.3 1.03 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.604285648890905 7577991 10.1021/bi00042a029 1995 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 2418 1254 231 T115V Thermonuclease Staphylococcus aureus 91.0 0.6 Unknown 53.3 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.604285648890905 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv 2513 1254 231 T115V Thermonuclease Staphylococcus aureus 89.0 2.3 Unknown 55.3 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.604285648890905 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm STRUM_Q306.csv, STRUM_Q3421.csv 4336 1254 231 T115V Thermonuclease Staphylococcus aureus Unknown 55.3 Sodium phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.604285648890905 11023780 10.1006/jmbi.2000.4140 2000 ProTherm 13520 1254 231 T115V Thermonuclease Staphylococcus aureus 0.92 -0.4 6.0 0.98 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.604285648890905 7577991 10.1021/bi00042a029 1995 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 13621 1254 231 T115V Thermonuclease Staphylococcus aureus 5.8 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.604285648890905 11023780 10.1006/jmbi.2000.4140 2000 ProTherm 2426 1262 231 T115C Thermonuclease Staphylococcus aureus 78.0 -3.6 Unknown 49.1 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.604285648890905 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm EASE-MM_S1676.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, AUTOMUTE_S1962.csv, Saraboji_S2204.csv 2521 1262 231 T115C Thermonuclease Staphylococcus aureus 74.0 -2.3 Unknown 50.7 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.604285648890905 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 13528 1262 231 T115C Thermonuclease Staphylococcus aureus 0.7 1.2 4.4 0.94 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.604285648890905 7577991 10.1021/bi00042a029 1995 ProTherm SAAFEC_S1262.csv 2433 1269 231 T115I Thermonuclease Staphylococcus aureus 92.0 1.1 Unknown 53.8 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.604285648890905 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, HotMuSiC_S1626.csv 2528 1269 231 T115I Thermonuclease Staphylococcus aureus 92.0 2.2 Unknown 55.2 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.604285648890905 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm Broom_S605.csv, EASE-MM_S238.csv 12779 1269 231 T115I Thermonuclease Staphylococcus aureus 0.95 -0.6 6.0 6.34 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.604285648890905 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 13087 6171 231 T115G Thermonuclease Staphylococcus aureus 0.4 2.5 3.0 1.1 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.604285648890905 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13088 6172 231 T115A Thermonuclease Staphylococcus aureus 0.56 1.4 4.1 1.07 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.604285648890905 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 15523 7214 231 T115S, A172S Thermonuclease Staphylococcus aureus 3.16 1.2 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 8.0 1STN 12.604285648890905, 7.815999984741211 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15548 7238 231 L119A, T115S Thermonuclease Staphylococcus aureus 2.21 1.01 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 9.0 1STN 12.604285648890905, 12.043750047683716 in tunnel in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15551 7241 231 E157V, T115S Thermonuclease Staphylococcus aureus 3.21 0.89 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 8.0 1STN 12.604285648890905, 12.881110933091906 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 277 148 231 F116C Thermonuclease Staphylococcus aureus -13.0 Unknown 40.0 MOPS 25 mM Potassium chloride 100 mM Activity Thermal 7.6 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 10.447272907603871 in pocket 20194783 10.1073/pnas.0910421107 2010 ProTherm 2894 148 231 F116C Thermonuclease Staphylococcus aureus -13.0 Unknown 40.0 MOPS 25 mM Potassium chloride 100 mM Quantitative cysteine reactivity Thermal 7.6 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 10.447272907603871 in pocket 20194783 10.1073/pnas.0910421107 2010 ProTherm Saraboji_S2204.csv, M47andM8_S1810.csv, M47andM8_S2760.csv 12711 148 231 F116C Thermonuclease Staphylococcus aureus 2.8 2.7 72.0 Unknown MOPS 25 mM 20.0 Potassium chloride 100 mM Activity Thermal 7.6 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 10.447272907603871 in pocket 20194783 10.1073/pnas.0910421107 2010 ProTherm 13153 148 231 F116C Thermonuclease Staphylococcus aureus 2.7 72.0 Unknown MOPS 25 mM 20.0 Potassium chloride 100 mM Quantitative cysteine reactivity Thermal 7.6 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 10.447272907603871 in pocket 20194783 10.1073/pnas.0910421107 2010 ProTherm 13170 6204 231 F116E Thermonuclease Staphylococcus aureus 1.1 3.9 5.6 4.9 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 3.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 10.447272907603871 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13171 6204 231 F116E Thermonuclease Staphylococcus aureus 1.1 5.4 6.4 5.6 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 10.447272907603871 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13172 6204 231 F116E Thermonuclease Staphylococcus aureus 0.9 6.5 5.2 5.7 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 6.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 10.447272907603871 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13173 6204 231 F116E Thermonuclease Staphylococcus aureus 0.7 8.1 3.8 5.6 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 10.447272907603871 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13174 6204 231 F116E Thermonuclease Staphylococcus aureus 0.6 7.9 3.7 5.8 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 9.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 10.447272907603871 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13467 6331 231 F116A Thermonuclease Staphylococcus aureus 0.2 3.7 1.78 1.12 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 10.447272907603871 in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12906 6031 231 R117A Thermonuclease Staphylococcus aureus 0.6 1.4 4.2 1.01 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS active site 9.0 1STN 11.456363721327348 in tunnel in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12907 6032 231 R117G Thermonuclease Staphylococcus aureus 0.46 2.2 3.4 1.03 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS active site 9.0 1STN 11.456363721327348 in tunnel in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 278 149 231 L118C Thermonuclease Staphylococcus aureus -14.0 Unknown 39.0 MOPS 25 mM Potassium chloride 100 mM Activity Thermal 7.6 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.5 in tunnel in pocket 20194783 10.1073/pnas.0910421107 2010 ProTherm 2895 149 231 L118C Thermonuclease Staphylococcus aureus -14.0 Unknown 39.0 MOPS 25 mM Potassium chloride 100 mM Quantitative cysteine reactivity Thermal 7.6 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.5 in tunnel in pocket 20194783 10.1073/pnas.0910421107 2010 ProTherm Broom_S605.csv, STRUM_Q3421.csv 12712 149 231 L118C Thermonuclease Staphylococcus aureus 2.9 2.6 71.0 Unknown MOPS 25 mM 20.0 Potassium chloride 100 mM Activity Thermal 7.6 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.5 in tunnel in pocket 20194783 10.1073/pnas.0910421107 2010 ProTherm 12713 149 231 L118C Thermonuclease Staphylococcus aureus -0.6 Unknown MOPS 25 mM 20.0 Potassium chloride 100 mM Activity Thermal 7.6 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.5 in tunnel in pocket 20194783 10.1073/pnas.0910421107 2010 ProTherm 12714 149 231 L118C Thermonuclease Staphylococcus aureus -0.7 Unknown MOPS 25 mM 20.0 Potassium chloride 50 microM pdTp Activity Thermal 7.6 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.5 in tunnel in pocket 20194783 10.1073/pnas.0910421107 2010 ProTherm 13154 149 231 L118C Thermonuclease Staphylococcus aureus 2.6 71.0 Unknown MOPS 25 mM 20.0 Potassium chloride 100 mM Quantitative cysteine reactivity Thermal 7.6 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.5 in tunnel in pocket 20194783 10.1073/pnas.0910421107 2010 ProTherm 12761 5917 231 L118I Thermonuclease Staphylococcus aureus 0.35 3.1 2.3 6.64 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.5 in tunnel in pocket 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv 12762 5918 231 L118V Thermonuclease Staphylococcus aureus 0.26 3.5 1.9 7.35 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.5 in tunnel in pocket 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv 13125 6190 231 L118A Thermonuclease Staphylococcus aureus -3.6 1.15 yes Na2HPO4 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.5 in tunnel in pocket 2381904 10.1002/prot.340070402 1990 ProTherm 13409 6190 231 L118A Thermonuclease Staphylococcus aureus 0.2 3.5 1.98 1.13 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.5 in tunnel in pocket 2261461 10.1021/bi00487a007 1990 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13126 6191 231 L118G Thermonuclease Staphylococcus aureus -5.4 1.24 yes Na2HPO4 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.5 in tunnel in pocket 2381904 10.1002/prot.340070402 1990 ProTherm 13410 6191 231 L118G Thermonuclease Staphylococcus aureus 0.0 5.3 0.18 1.23 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.5 in tunnel in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13175 6205 231 L118E Thermonuclease Staphylococcus aureus 1.0 4.7 4.8 4.9 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 3.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.5 in tunnel in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13176 6205 231 L118E Thermonuclease Staphylococcus aureus 1.3 4.2 6.9 5.2 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 4.4 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.5 in tunnel in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13177 6205 231 L118E Thermonuclease Staphylococcus aureus 1.3 4.6 7.2 5.4 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.5 in tunnel in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13178 6205 231 L118E Thermonuclease Staphylococcus aureus 1.1 5.3 6.4 5.7 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 6.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.5 in tunnel in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13179 6205 231 L118E Thermonuclease Staphylococcus aureus 0.7 7.5 4.4 6.1 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.5 in tunnel in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13180 6205 231 L118E Thermonuclease Staphylococcus aureus 0.5 8.4 3.2 6.4 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 9.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.5 in tunnel in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13181 6205 231 L118E Thermonuclease Staphylococcus aureus 0.2 8.8 1.5 7.7 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 9.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.5 in tunnel in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 12763 5919 231 L119I Thermonuclease Staphylococcus aureus 0.57 2.0 3.4 6.0 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 12.043750047683716 in tunnel in pocket 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv 12764 5920 231 L119V Thermonuclease Staphylococcus aureus 0.43 3.0 2.4 5.53 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 12.043750047683716 in tunnel in pocket 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv 13127 6192 231 L119A Thermonuclease Staphylococcus aureus -1.8 0.9 yes Na2HPO4 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 12.043750047683716 in tunnel in pocket 2381904 10.1002/prot.340070402 1990 ProTherm 13411 6192 231 L119A Thermonuclease Staphylococcus aureus 0.6 1.7 3.78 0.89 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 12.043750047683716 in tunnel in pocket 2261461 10.1021/bi00487a007 1990 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13128 6193 231 L119G Thermonuclease Staphylococcus aureus -3.9 0.95 yes Na2HPO4 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 12.043750047683716 in tunnel in pocket 2381904 10.1002/prot.340070402 1990 ProTherm 13412 6193 231 L119G Thermonuclease Staphylococcus aureus 0.2 3.8 1.68 0.94 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 12.043750047683716 in tunnel in pocket 2261461 10.1021/bi00487a007 1990 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13182 6206 231 L119E Thermonuclease Staphylococcus aureus 1.6 2.1 7.4 4.6 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 3.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 12.043750047683716 in tunnel in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13183 6206 231 L119E Thermonuclease Staphylococcus aureus 1.8 2.7 9.1 5.1 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 12.043750047683716 in tunnel in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13184 6206 231 L119E Thermonuclease Staphylococcus aureus 1.7 3.2 8.5 5.0 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 6.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 12.043750047683716 in tunnel in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13185 6206 231 L119E Thermonuclease Staphylococcus aureus 1.7 3.1 8.8 5.1 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 8.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 12.043750047683716 in tunnel in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm SAAFEC_S1262.csv 15504 7199 231 L119A, L120A Thermonuclease Staphylococcus aureus 1.8 0.91 Unknown NaH2PO4 10 mM 20.0 NaCl 100 mM CD GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0, 9.0 1STN 12.043750047683716, 15.117500066757202 in tunnel in pocket 1620695 10.1002/prot.340130206 1992 ProTherm 15532 7223 231 L119A, E157V Thermonuclease Staphylococcus aureus 2.47 0.79 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0, 8.0 1STN 12.043750047683716, 12.881110933091906 in tunnel in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15533 7224 231 L119A, G161S Thermonuclease Staphylococcus aureus 1.83 0.87 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0, 6.0 1STN 12.043750047683716, 12.882500171661377 in tunnel in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15534 7225 231 L119A, P199L Thermonuclease Staphylococcus aureus 1.69 0.85 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0, 7.0 1STN 12.043750047683716, 22.304285866873606 in tunnel in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15535 7226 231 L119A, N200D Thermonuclease Staphylococcus aureus 1.72 0.91 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0, 8.0 1STN 12.043750047683716, 15.703750133514404 in tunnel in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15549 7239 231 L119A, A151T Thermonuclease Staphylococcus aureus 4.13 1.09 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0, 6.0 1STN 12.043750047683716, 15.82599983215332 in tunnel in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15550 7240 231 L119A, A172S Thermonuclease Staphylococcus aureus 3.32 1.02 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0, 8.0 1STN 12.043750047683716, 7.815999984741211 in tunnel in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15568 7258 231 L119A, I154V Thermonuclease Staphylococcus aureus 2.78 1.01 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0, 8.0 1STN 12.043750047683716, 10.5625 in tunnel in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15569 7259 231 L119A, Y167A Thermonuclease Staphylococcus aureus 1.98 0.9 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0, 9.0 1STN 12.043750047683716, 18.133333285649616 in tunnel in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15570 7260 231 L119A, I174V Thermonuclease Staphylococcus aureus 1.77 0.99 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0, 8.0 1STN 12.043750047683716, 9.303750038146973 in tunnel in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15571 7261 231 L119A, Y195A Thermonuclease Staphylococcus aureus 1.46 0.92 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0, 9.0 1STN 12.043750047683716, 33.795000076293945 in tunnel in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15572 7262 231 L119A, A212G Thermonuclease Staphylococcus aureus 2.53 0.89 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0, 4.0 1STN 12.043750047683716, 13.848000144958496 in tunnel in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 12765 5921 231 L120I Thermonuclease Staphylococcus aureus 0.51 2.1 3.3 6.47 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 15.117500066757202 in tunnel in pocket 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv 12766 5922 231 L120V Thermonuclease Staphylococcus aureus 0.81 0.2 5.2 6.41 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 15.117500066757202 in tunnel in pocket 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 13186 6207 231 L120E Thermonuclease Staphylococcus aureus 1.8 1.2 8.3 4.6 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 3.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 15.117500066757202 in tunnel in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13187 6207 231 L120E Thermonuclease Staphylococcus aureus 2.0 2.0 9.3 4.7 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 4.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 15.117500066757202 in tunnel in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13188 6207 231 L120E Thermonuclease Staphylococcus aureus 1.9 2.3 9.5 5.0 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 15.117500066757202 in tunnel in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13189 6207 231 L120E Thermonuclease Staphylococcus aureus 1.7 3.4 8.3 4.9 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 5.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 15.117500066757202 in tunnel in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13190 6207 231 L120E Thermonuclease Staphylococcus aureus 1.4 4.6 6.9 5.0 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 15.117500066757202 in tunnel in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13191 6207 231 L120E Thermonuclease Staphylococcus aureus 1.3 4.6 6.9 5.3 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 9.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 15.117500066757202 in tunnel in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13413 6286 231 L120A Thermonuclease Staphylococcus aureus 0.6 1.7 3.78 0.94 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 15.117500066757202 in tunnel in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13556 6286 231 L120A Thermonuclease Staphylococcus aureus 0.6 1.6 3.8 0.96 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 15.117500066757202 in tunnel in pocket 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm SAAFEC_S1262.csv 13414 6287 231 L120G Thermonuclease Staphylococcus aureus 0.8 0.6 4.88 0.9 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 15.117500066757202 in tunnel in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13557 6287 231 L120G Thermonuclease Staphylococcus aureus 0.8 0.5 4.9 0.92 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 15.117500066757202 in tunnel in pocket 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 15505 7200 231 L120A, V121A Thermonuclease Staphylococcus aureus 4.0 0.92 Unknown NaH2PO4 10 mM 20.0 NaCl 100 mM CD GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0, 8.0 1STN 15.117500066757202, 14.460000038146973 in tunnel in pocket 1620695 10.1002/prot.340130206 1992 ProTherm 2381 1218 231 V121T Thermonuclease Staphylococcus aureus 75.0 -7.5 Unknown 45.2 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 14.460000038146973 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm M47andM8_S1810.csv, M47andM8_S2760.csv, Broom_S605.csv, PoPMuSiC-2.0_S2648.csv, EASE-MM_S1676.csv, PON-TStab_dataset.csv, STRUM_Q3421.csv 2476 1218 231 V121T Thermonuclease Staphylococcus aureus 73.0 -6.0 Unknown 47.0 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 14.460000038146973 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm Broom_S605.csv 13479 1218 231 V121T Thermonuclease Staphylococcus aureus 0.56 1.3 4.3 1.08 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 14.460000038146973 in tunnel in pocket 7577991 10.1021/bi00042a029 1995 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 2389 1226 231 V121S Thermonuclease Staphylococcus aureus 69.0 -11.0 Unknown 41.7 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 14.460000038146973 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, HotMuSiC_S1626.csv 2484 1226 231 V121S Thermonuclease Staphylococcus aureus 66.0 -10.6 Unknown 42.4 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 14.460000038146973 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv 13488 1226 231 V121S Thermonuclease Staphylococcus aureus 0.46 2.4 3.2 1.03 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 14.460000038146973 in tunnel in pocket 7577991 10.1021/bi00042a029 1995 ProTherm SAAFEC_S1262.csv 12728 5886 231 V121I Thermonuclease Staphylococcus aureus 0.84 -0.1 5.5 6.61 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 14.460000038146973 in tunnel in pocket 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 12729 5887 231 V121L Thermonuclease Staphylococcus aureus 0.68 0.9 4.5 6.68 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 14.460000038146973 in tunnel in pocket 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv 13192 6208 231 V121E Thermonuclease Staphylococcus aureus 1.2 3.9 5.6 4.9 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 3.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 14.460000038146973 in tunnel in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13193 6208 231 V121E Thermonuclease Staphylococcus aureus 1.4 4.2 7.5 5.3 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 4.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 14.460000038146973 in tunnel in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13194 6208 231 V121E Thermonuclease Staphylococcus aureus 1.2 4.7 7.0 5.6 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 6.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 14.460000038146973 in tunnel in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13195 6208 231 V121E Thermonuclease Staphylococcus aureus 0.9 6.6 5.3 5.9 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 14.460000038146973 in tunnel in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13196 6208 231 V121E Thermonuclease Staphylococcus aureus 0.8 7.2 4.4 5.8 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 9.1 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 14.460000038146973 in tunnel in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13422 6292 231 V121A Thermonuclease Staphylococcus aureus 0.4 2.2 3.28 0.99 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 14.460000038146973 in tunnel in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13423 6293 231 V121G Thermonuclease Staphylococcus aureus 0.1 4.7 0.78 0.79 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 14.460000038146973 in tunnel in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12816 5948 231 D122A Thermonuclease Staphylococcus aureus 0.89 -0.2 5.8 0.94 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS binding site 9.0 1STN 19.68500018119812 in tunnel in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 12817 5949 231 D122G Thermonuclease Staphylococcus aureus 0.76 0.5 5.1 0.97 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS binding site 9.0 1STN 19.68500018119812 in tunnel in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 2411 1247 231 T123S Thermonuclease Staphylococcus aureus 79.0 -3.1 Unknown 49.6 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS binding site 9.0 1STN 16.144285883222306 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 2506 1247 231 T123S Thermonuclease Staphylococcus aureus 72.0 -2.4 Unknown 50.6 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS binding site 9.0 1STN 16.144285883222306 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 13513 1247 231 T123S Thermonuclease Staphylococcus aureus 0.73 1.1 4.5 0.92 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS binding site 9.0 1STN 16.144285883222306 in pocket 7577991 10.1021/bi00042a029 1995 ProTherm SAAFEC_S1262.csv 2419 1255 231 T123V Thermonuclease Staphylococcus aureus 94.0 2.7 Unknown 55.4 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS binding site 9.0 1STN 16.144285883222306 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 2514 1255 231 T123V Thermonuclease Staphylococcus aureus 94.0 4.2 Unknown 57.2 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS binding site 9.0 1STN 16.144285883222306 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm STRUM_Q306.csv, STRUM_Q3421.csv 13521 1255 231 T123V Thermonuclease Staphylococcus aureus 0.98 -0.8 6.4 0.97 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS binding site 9.0 1STN 16.144285883222306 in pocket 7577991 10.1021/bi00042a029 1995 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 2427 1263 231 T123C Thermonuclease Staphylococcus aureus 93.0 1.3 Unknown 54.0 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS binding site 9.0 1STN 16.144285883222306 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm M47andM8_S1810.csv, M47andM8_S2760.csv 2522 1263 231 T123C Thermonuclease Staphylococcus aureus 91.0 2.9 Unknown 55.9 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS binding site 9.0 1STN 16.144285883222306 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm EASE-MM_S543.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv 13529 1263 231 T123C Thermonuclease Staphylococcus aureus 0.96 -0.6 6.2 0.96 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS binding site 9.0 1STN 16.144285883222306 in pocket 7577991 10.1021/bi00042a029 1995 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 2434 1270 231 T123I Thermonuclease Staphylococcus aureus 102.0 4.0 Unknown 56.7 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS binding site 9.0 1STN 16.144285883222306 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv 2529 1270 231 T123I Thermonuclease Staphylococcus aureus 98.0 4.2 Unknown 57.2 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS binding site 9.0 1STN 16.144285883222306 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm Broom_S605.csv, STRUM_Q3421.csv, EASE-MM_S238.csv 4337 1270 231 T123I Thermonuclease Staphylococcus aureus Unknown 57.2 Sodium phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS binding site 9.0 1STN 16.144285883222306 in pocket 11023780 10.1006/jmbi.2000.4140 2000 ProTherm 12780 1270 231 T123I Thermonuclease Staphylococcus aureus 1.0 -0.7 6.1 6.14 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS binding site 9.0 1STN 16.144285883222306 in pocket 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv 13622 1270 231 T123I Thermonuclease Staphylococcus aureus 6.1 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS binding site 9.0 1STN 16.144285883222306 in pocket 11023780 10.1006/jmbi.2000.4140 2000 ProTherm 13089 6173 231 T123G Thermonuclease Staphylococcus aureus 0.57 2.0 3.5 0.9 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS binding site 9.0 1STN 16.144285883222306 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13090 6174 231 T123A Thermonuclease Staphylococcus aureus 0.82 0.0 5.5 0.98 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS binding site 9.0 1STN 16.144285883222306 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 13197 6209 231 T123E Thermonuclease Staphylococcus aureus 1.6 2.1 7.3 4.6 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 3.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS binding site 9.0 1STN 16.144285883222306 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13198 6209 231 T123E Thermonuclease Staphylococcus aureus 1.8 2.6 9.2 5.2 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS binding site 9.0 1STN 16.144285883222306 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13199 6209 231 T123E Thermonuclease Staphylococcus aureus 1.6 3.0 8.7 5.3 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 6.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS binding site 9.0 1STN 16.144285883222306 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm SAAFEC_S983.csv 13200 6209 231 T123E Thermonuclease Staphylococcus aureus 1.5 4.3 7.6 5.2 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 8.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS binding site 9.0 1STN 16.144285883222306 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13201 6209 231 T123E Thermonuclease Staphylococcus aureus 1.4 4.0 7.6 5.3 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 9.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS binding site 9.0 1STN 16.144285883222306 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13028 6117 231 P124G Thermonuclease Staphylococcus aureus 0.84 0.4 5.1 0.89 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 16.40428556714739 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 13029 6118 231 P124A Thermonuclease Staphylococcus aureus 0.84 -0.1 5.6 0.98 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 16.40428556714739 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 15498 7193 231 H206L, P124G Thermonuclease Staphylococcus aureus 0.75 yes Bis-Tris 10 mM 21.0 Fluorescence GdnHCl 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0, 4.0 1STN 16.40428556714739, 25.575000286102295 in pocket 8620010 10.1021/bi952012g 1996 ProTherm 12830 5960 231 E125A Thermonuclease Staphylococcus aureus 0.85 -0.3 5.9 1.0 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS active site 9.0 1STN 23.77222230699327 in tunnel 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 12831 5961 231 E125G Thermonuclease Staphylococcus aureus 0.9 -0.5 6.1 0.97 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS active site 9.0 1STN 23.77222230699327 in tunnel 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 13472 6332 231 E125D Thermonuclease Staphylococcus aureus 0.92 -0.2 5.7 0.96 Unknown Potassium phosphate 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS active site 9.0 1STN 23.77222230699327 in tunnel 2015219 10.1021/bi00229a005 1991 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 2412 1248 231 T126S Thermonuclease Staphylococcus aureus 89.0 -0.5 Unknown 52.2 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 23.71714292253767 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 2507 1248 231 T126S Thermonuclease Staphylococcus aureus 88.0 0.3 Unknown 53.3 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 23.71714292253767 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S499.csv 13514 1248 231 T126S Thermonuclease Staphylococcus aureus 0.84 0.0 5.6 0.99 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 23.71714292253767 7577991 10.1021/bi00042a029 1995 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 2420 1256 231 T126V Thermonuclease Staphylococcus aureus 88.0 -0.5 Unknown 52.2 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 23.71714292253767 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, HotMuSiC_S1626.csv, Saraboji_S2204.csv, AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 2515 1256 231 T126V Thermonuclease Staphylococcus aureus 89.0 1.0 Unknown 54.0 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 23.71714292253767 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 13522 1256 231 T126V Thermonuclease Staphylococcus aureus 0.84 -0.1 5.7 1.0 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 23.71714292253767 7577991 10.1021/bi00042a029 1995 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 2428 1264 231 T126C Thermonuclease Staphylococcus aureus 83.0 -0.3 Unknown 52.4 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 23.71714292253767 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, SVM-WIN31_SVM-3D12_S499.csv, M47andM8_S1810.csv 2523 1264 231 T126C Thermonuclease Staphylococcus aureus 86.0 0.5 Unknown 53.5 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 23.71714292253767 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm Broom_S605.csv, EASE-MM_S543.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv, PON-TStab_dataset.csv 13530 1264 231 T126C Thermonuclease Staphylococcus aureus 0.85 0.2 5.4 0.94 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 23.71714292253767 7577991 10.1021/bi00042a029 1995 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 2435 1271 231 T126I Thermonuclease Staphylococcus aureus 82.0 -4.2 Unknown 48.5 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 23.71714292253767 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv 2530 1271 231 T126I Thermonuclease Staphylococcus aureus 78.0 -3.3 Unknown 49.7 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 23.71714292253767 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm Broom_S605.csv, PoPMuSiC-2.0_S2648.csv, EASE-MM_S238.csv, STRUM_Q3421.csv 12781 1271 231 T126I Thermonuclease Staphylococcus aureus 0.74 0.6 4.8 6.48 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 23.71714292253767 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 13091 6175 231 T126G Thermonuclease Staphylococcus aureus 0.78 0.6 4.9 0.93 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 23.71714292253767 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 13092 6176 231 T126A Thermonuclease Staphylococcus aureus 0.79 0.4 5.1 0.96 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 23.71714292253767 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 12864 5990 231 K127A Thermonuclease Staphylococcus aureus 0.81 -0.3 5.9 1.05 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 40.31777763366699 in tunnel 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 13582 5990 231 K127A Thermonuclease Staphylococcus aureus 0.81 -0.3 5.7 1.05 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 40.31777763366699 in tunnel 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 12865 5991 231 K127G Thermonuclease Staphylococcus aureus 0.83 -0.2 5.8 1.01 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 40.31777763366699 in tunnel 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 13583 5991 231 K127G Thermonuclease Staphylococcus aureus 0.83 -0.2 5.6 1.01 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 40.31777763366699 in tunnel 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 3443 1791 231 H128Y Thermonuclease Staphylococcus aureus 69.4 -0.6 yes 47.2 Unknown NaCl 0.3 M NMR Thermal 5.38 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 42.43699989318848 in tunnel 2372535 10.1021/bi00471a003 1990 ProTherm AUTOMUTE_S1962.csv, Broom_S605.csv, capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8091 1791 231 H128Y Thermonuclease Staphylococcus aureus 0.0 0.0 1.4 yes Unknown 40.0 NaCl 0.3 M NMR Thermal 5.38 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 42.43699989318848 in tunnel 2372535 10.1021/bi00471a003 1990 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 12900 6025 231 H128A Thermonuclease Staphylococcus aureus 0.74 0.5 5.1 0.98 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 42.43699989318848 in tunnel 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 12901 6026 231 H128G Thermonuclease Staphylococcus aureus 0.81 0.4 5.2 0.93 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 42.43699989318848 in tunnel 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 2442 1278 231 P129F Thermonuclease Staphylococcus aureus 85.0 -0.9 Unknown 51.8 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 41.308570861816406 in tunnel 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 2537 1278 231 P129F Thermonuclease Staphylococcus aureus 83.0 -0.2 Unknown 52.8 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 41.308570861816406 in tunnel 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv, Broom_S605.csv 13337 1278 231 P129F Thermonuclease Staphylococcus aureus 0.83 0.3 5.2 0.95 yes Sodium phosphate 25 mM 20.0 NaCl 600 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 41.308570861816406 in tunnel 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 13030 6119 231 P129G Thermonuclease Staphylococcus aureus 0.87 0.1 5.4 0.92 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 41.308570861816406 in tunnel 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 13031 6120 231 P129A Thermonuclease Staphylococcus aureus 0.79 0.6 4.9 0.92 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 41.308570861816406 in tunnel 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 15499 7194 231 H206L, P129G Thermonuclease Staphylococcus aureus 0.75 2.8 5.7 yes Bis-Tris 10 mM 21.0 Fluorescence GdnHCl 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 4.0 1STN 41.308570861816406, 25.575000286102295 in tunnel 8620010 10.1021/bi952012g 1996 ProTherm 15501 7196 231 H206L, P129G, P199G Thermonuclease Staphylococcus aureus 0.75 3.47 5.28 yes Bis-Tris 10 mM 21.0 Fluorescence GdnHCl 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 7.0, 4.0 1STN 41.308570861816406, 22.304285866873606, 25.575000286102295 in tunnel in pocket 8620010 10.1021/bi952012g 1996 ProTherm 2443 1279 231 K130F Thermonuclease Staphylococcus aureus 84.0 -0.4 Unknown 52.3 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 58.93888939751519 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 2538 1279 231 K130F Thermonuclease Staphylococcus aureus 88.0 0.3 Unknown 53.3 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 58.93888939751519 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm STRUM_Q3421.csv, PoPMuSiC-2.0_S2648.csv, Broom_S605.csv 13338 1279 231 K130F Thermonuclease Staphylococcus aureus 0.83 0.5 5.0 0.91 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 58.93888939751519 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 12866 5992 231 K130A Thermonuclease Staphylococcus aureus 0.81 -0.1 5.7 1.03 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 58.93888939751519 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 12867 5993 231 K130G Thermonuclease Staphylococcus aureus 0.84 -0.2 5.8 1.01 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 58.93888939751519 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 12924 6047 231 K130E Thermonuclease Staphylococcus aureus 0.85 0.0 5.4 6.34 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 58.93888939751519 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 12925 6048 231 K130Q Thermonuclease Staphylococcus aureus 0.83 0.1 5.3 6.47 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 58.93888939751519 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 2444 1280 231 K131F Thermonuclease Staphylococcus aureus 88.0 -1.2 Unknown 51.5 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 54.6944448682997 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm EASE-MM_S238.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 2539 1280 231 K131F Thermonuclease Staphylococcus aureus 88.0 -0.8 Unknown 52.2 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 54.6944448682997 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm PoPMuSiC-2.0_S2648.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv, STRUM_Q3421.csv 13339 1280 231 K131F Thermonuclease Staphylococcus aureus 0.89 0.0 5.5 0.94 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 54.6944448682997 in pocket 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 12868 5994 231 K131A Thermonuclease Staphylococcus aureus 0.77 0.3 5.3 0.99 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 54.6944448682997 in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 13580 5994 231 K131A Thermonuclease Staphylococcus aureus 0.77 0.3 5.1 0.99 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 54.6944448682997 in pocket 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 12869 5995 231 K131G Thermonuclease Staphylococcus aureus 0.8 0.2 5.4 0.97 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 54.6944448682997 in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 13581 5995 231 K131G Thermonuclease Staphylococcus aureus 0.8 0.2 5.2 0.97 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 54.6944448682997 in pocket 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 4254 2161 231 G132C Thermonuclease Staphylococcus aureus -2.6 yes 50.4 Sodium phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 39.58749961853027 8580845 10.1002/pro.5560041211 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 13603 2161 231 G132C Thermonuclease Staphylococcus aureus 0.73 0.8 4.7 6.42 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 39.58749961853027 8580845 10.1002/pro.5560041211 1995 ProTherm SAAFEC_S1262.csv 4263 2169 231 G132F Thermonuclease Staphylococcus aureus -2.5 yes 50.5 Sodium phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 39.58749961853027 8580845 10.1002/pro.5560041211 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 13340 2169 231 G132F Thermonuclease Staphylococcus aureus 0.75 0.8 4.7 0.94 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 39.58749961853027 9578580 10.1021/bi9725069 1998 ProTherm 13612 2169 231 G132F Thermonuclease Staphylococcus aureus 0.77 0.4 5.1 6.71 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 39.58749961853027 8580845 10.1002/pro.5560041211 1995 ProTherm 13040 6128 231 G132A Thermonuclease Staphylococcus aureus 0.81 -0.2 5.7 1.04 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 39.58749961853027 1610820 10.1021/bi00140a005 1992 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 13589 6128 231 G132A Thermonuclease Staphylococcus aureus 0.81 -0.3 5.7 1.04 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 39.58749961853027 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 13041 6129 231 G132V Thermonuclease Staphylococcus aureus 0.67 1.1 4.4 0.96 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 39.58749961853027 1610820 10.1021/bi00140a005 1992 ProTherm SAAFEC_S1262.csv 2382 1219 231 V133T Thermonuclease Staphylococcus aureus 95.0 -1.0 Unknown 51.7 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 33.11142839704241 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm HotMuSiC_S1626.csv, PoPMuSiC-2.0_S2648.csv, PON-TStab_dataset.csv 2477 1219 231 V133T Thermonuclease Staphylococcus aureus 88.0 0.5 Unknown 53.5 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 33.11142839704241 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv 13480 1219 231 V133T Thermonuclease Staphylococcus aureus 0.86 -0.2 5.8 1.0 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 33.11142839704241 7577991 10.1021/bi00042a029 1995 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 2390 1227 231 V133S Thermonuclease Staphylococcus aureus 85.0 -0.6 Unknown 52.1 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 33.11142839704241 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, M47andM8_S1810.csv, HotMuSiC_S1626.csv 2485 1227 231 V133S Thermonuclease Staphylococcus aureus 90.0 0.5 Unknown 53.5 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 33.11142839704241 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 13489 1227 231 V133S Thermonuclease Staphylococcus aureus 0.85 0.1 5.5 0.96 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 33.11142839704241 7577991 10.1021/bi00042a029 1995 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 12730 5888 231 V133I Thermonuclease Staphylococcus aureus 0.83 -0.1 5.5 6.54 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 33.11142839704241 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 12731 5889 231 V133L Thermonuclease Staphylococcus aureus 0.82 0.2 5.2 6.28 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 33.11142839704241 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 13424 6294 231 V133A Thermonuclease Staphylococcus aureus 0.8 0.3 5.18 0.93 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 33.11142839704241 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 13564 6294 231 V133A Thermonuclease Staphylococcus aureus 0.82 0.2 5.2 0.95 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 33.11142839704241 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 13425 6295 231 V133G Thermonuclease Staphylococcus aureus 0.8 0.4 5.08 0.94 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 33.11142839704241 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13565 6295 231 V133G Thermonuclease Staphylococcus aureus 0.8 0.3 5.1 0.96 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 33.11142839704241 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 2445 1281 231 E134F Thermonuclease Staphylococcus aureus 84.0 -0.5 Unknown 52.2 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 29.788889355129665 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 2540 1281 231 E134F Thermonuclease Staphylococcus aureus 81.0 0.0 Unknown 53.0 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 29.788889355129665 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv, Broom_S605.csv 13341 1281 231 E134F Thermonuclease Staphylococcus aureus 0.78 0.7 4.8 0.94 yes Sodium phosphate 25 mM 20.0 NaCl 600 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 29.788889355129665 in pocket 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv 12832 5962 231 E134A Thermonuclease Staphylococcus aureus 0.8 0.1 5.5 0.98 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 29.788889355129665 in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 13578 5962 231 E134A Thermonuclease Staphylococcus aureus 0.8 0.1 5.3 0.98 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 29.788889355129665 in pocket 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 12833 5963 231 E134G Thermonuclease Staphylococcus aureus 0.78 0.4 5.2 0.95 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 29.788889355129665 in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 13579 5963 231 E134G Thermonuclease Staphylococcus aureus 0.78 0.4 5.0 0.95 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 29.788889355129665 in pocket 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 12870 5996 231 K135A Thermonuclease Staphylococcus aureus 0.78 0.2 5.2 0.96 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 38.04222212897407 in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 12871 5997 231 K135G Thermonuclease Staphylococcus aureus 0.82 0.3 5.3 0.93 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 38.04222212897407 in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 2394 1231 231 Y136F Thermonuclease Staphylococcus aureus 81.0 -1.8 Unknown 50.9 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 25.445833524068195 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm EASE-MM_S1676.csv, AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 2489 1231 231 Y136F Thermonuclease Staphylococcus aureus 82.0 -0.2 Unknown 52.8 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 25.445833524068195 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 13497 1231 231 Y136F Thermonuclease Staphylococcus aureus 0.79 0.5 5.1 0.96 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 25.445833524068195 in pocket 7577991 10.1021/bi00042a029 1995 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 2400 1237 231 Y136L Thermonuclease Staphylococcus aureus 54.0 -12.4 Unknown 40.3 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 25.445833524068195 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm STRUM_Q3421.csv, AUTOMUTE_S1962.csv, Broom_S605.csv, Saraboji_S2204.csv 2495 1237 231 Y136L Thermonuclease Staphylococcus aureus 55.0 -12.0 Unknown 41.0 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 25.445833524068195 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 13504 1237 231 Y136L Thermonuclease Staphylococcus aureus 0.35 3.4 2.2 0.95 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 25.445833524068195 in pocket 7577991 10.1021/bi00042a029 1995 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13458 6322 231 Y136A Thermonuclease Staphylococcus aureus 0.5 2.2 3.28 0.89 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 25.445833524068195 in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13558 6322 231 Y136A Thermonuclease Staphylococcus aureus 0.54 2.1 3.3 0.89 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 25.445833524068195 in pocket 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm SAAFEC_S1262.csv 13459 6323 231 Y136G Thermonuclease Staphylococcus aureus 0.5 1.9 3.58 0.93 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 25.445833524068195 in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13559 6323 231 Y136G Thermonuclease Staphylococcus aureus 0.57 1.8 3.6 0.93 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 25.445833524068195 in pocket 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm SAAFEC_S1262.csv 13042 6130 231 G137A Thermonuclease Staphylococcus aureus 0.76 0.6 4.9 0.95 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 17.12750005722046 1610820 10.1021/bi00140a005 1992 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 13043 6131 231 G137V Thermonuclease Staphylococcus aureus 0.63 1.8 3.7 0.86 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 17.12750005722046 1610820 10.1021/bi00140a005 1992 ProTherm SAAFEC_S1262.csv 13032 6121 231 P138G Thermonuclease Staphylococcus aureus 0.72 1.0 4.5 0.92 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 16.098571641104563 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13033 6122 231 P138A Thermonuclease Staphylococcus aureus 0.84 0.0 5.5 0.95 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 16.098571641104563 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 2446 1282 231 E139F Thermonuclease Staphylococcus aureus 85.0 -1.1 Unknown 51.6 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 19.948889202541775 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 2541 1282 231 E139F Thermonuclease Staphylococcus aureus 80.0 -0.6 Unknown 52.4 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 19.948889202541775 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Broom_S605.csv, Saraboji_S1791.csv 4264 1282 231 E139F Thermonuclease Staphylococcus aureus -0.6 yes 52.4 Sodium phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 19.948889202541775 in pocket 8580845 10.1002/pro.5560041211 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 13342 1282 231 E139F Thermonuclease Staphylococcus aureus 0.72 0.7 4.8 1.01 yes Sodium phosphate 25 mM 20.0 NaCl 600 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 19.948889202541775 in pocket 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S983.csv 13613 1282 231 E139F Thermonuclease Staphylococcus aureus 0.72 0.9 4.6 6.28 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 19.948889202541775 in pocket 8580845 10.1002/pro.5560041211 1995 ProTherm SAAFEC_S1262.csv 4255 2162 231 E139C Thermonuclease Staphylococcus aureus -0.9 yes 52.1 Sodium phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 19.948889202541775 in pocket 8580845 10.1002/pro.5560041211 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 13604 2162 231 E139C Thermonuclease Staphylococcus aureus 0.75 0.7 4.8 6.39 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 19.948889202541775 in pocket 8580845 10.1002/pro.5560041211 1995 ProTherm SAAFEC_S1262.csv 12834 5964 231 E139A Thermonuclease Staphylococcus aureus 0.8 0.2 5.4 0.97 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 19.948889202541775 in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 12835 5965 231 E139G Thermonuclease Staphylococcus aureus 0.62 1.6 4.0 0.94 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 19.948889202541775 in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12926 6049 231 E139K Thermonuclease Staphylococcus aureus 0.84 0.1 5.3 6.27 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 19.948889202541775 in pocket 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 12927 6050 231 E139Q Thermonuclease Staphylococcus aureus 0.81 0.2 5.2 6.34 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 19.948889202541775 in pocket 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 13002 6091 231 A140G Thermonuclease Staphylococcus aureus 0.44 2.6 2.9 0.98 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 12.405999946594239 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13003 6092 231 A140V Thermonuclease Staphylococcus aureus 0.44 2.8 2.7 0.89 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 12.405999946594239 1610820 10.1021/bi00140a005 1992 ProTherm SAAFEC_S1262.csv 13202 6210 231 A140E Thermonuclease Staphylococcus aureus 1.2 3.8 5.7 4.6 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 3.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 12.405999946594239 20798341 10.1073/pnas.1004213107 2010 ProTherm 13203 6210 231 A140E Thermonuclease Staphylococcus aureus 1.4 4.5 7.5 5.3 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 4.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 12.405999946594239 20798341 10.1073/pnas.1004213107 2010 ProTherm 13204 6210 231 A140E Thermonuclease Staphylococcus aureus 1.2 4.8 6.9 5.5 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 5.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 12.405999946594239 20798341 10.1073/pnas.1004213107 2010 ProTherm 13205 6210 231 A140E Thermonuclease Staphylococcus aureus 0.9 6.9 5.0 5.3 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 8.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 12.405999946594239 20798341 10.1073/pnas.1004213107 2010 ProTherm 13206 6210 231 A140E Thermonuclease Staphylococcus aureus 0.9 6.9 4.7 5.4 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 9.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 12.405999946594239 20798341 10.1073/pnas.1004213107 2010 ProTherm 13207 6210 231 A140E Thermonuclease Staphylococcus aureus 0.7 6.4 3.9 5.6 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 9.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 12.405999946594239 20798341 10.1073/pnas.1004213107 2010 ProTherm 4338 2194 231 S141A Thermonuclease Staphylococcus aureus Unknown 56.2 Sodium phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 14.785000006357828 11023780 10.1006/jmbi.2000.4140 2000 ProTherm 13076 2194 231 S141A Thermonuclease Staphylococcus aureus 0.94 -0.4 5.9 0.92 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 14.785000006357828 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 13623 2194 231 S141A Thermonuclease Staphylococcus aureus 5.9 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 14.785000006357828 11023780 10.1006/jmbi.2000.4140 2000 ProTherm 13075 6162 231 S141G Thermonuclease Staphylococcus aureus 0.66 1.1 4.4 0.97 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 14.785000006357828 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13343 6246 231 S141F Thermonuclease Staphylococcus aureus 1.0 0.0 5.5 0.81 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 14.785000006357828 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 4256 2163 231 A142C Thermonuclease Staphylococcus aureus -3.6 yes 49.4 Sodium phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 12.623999977111817 in pocket 8580845 10.1002/pro.5560041211 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 13605 2163 231 A142C Thermonuclease Staphylococcus aureus 0.68 1.2 4.3 6.36 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 12.623999977111817 in pocket 8580845 10.1002/pro.5560041211 1995 ProTherm SAAFEC_S1262.csv 13004 6093 231 A142G Thermonuclease Staphylococcus aureus 0.6 1.4 4.1 0.99 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 12.623999977111817 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13129 6093 231 A142G Thermonuclease Staphylococcus aureus -1.5 1.0 yes Na2HPO4 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 12.623999977111817 in pocket 2381904 10.1002/prot.340070402 1990 ProTherm 13005 6094 231 A142V Thermonuclease Staphylococcus aureus 0.44 2.8 2.7 0.88 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 12.623999977111817 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13130 6094 231 A142V Thermonuclease Staphylococcus aureus -2.9 0.89 yes Na2HPO4 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 12.623999977111817 in pocket 2381904 10.1002/prot.340070402 1990 ProTherm 13344 6247 231 A142F Thermonuclease Staphylococcus aureus 0.71 0.8 4.7 1.0 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 12.623999977111817 in pocket 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv 13131 6194 231 F143A Thermonuclease Staphylococcus aureus -2.4 1.0 yes Na2HPO4 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 13.564545458013361 in pocket 2381904 10.1002/prot.340070402 1990 ProTherm 13468 6194 231 F143A Thermonuclease Staphylococcus aureus 0.4 2.3 3.18 0.99 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 13.564545458013361 in pocket 2261461 10.1021/bi00487a007 1990 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13132 6195 231 F143G Thermonuclease Staphylococcus aureus -4.7 1.04 yes Na2HPO4 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 13.564545458013361 in pocket 2381904 10.1002/prot.340070402 1990 ProTherm 13469 6195 231 F143G Thermonuclease Staphylococcus aureus 0.1 4.8 0.68 0.94 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 13.564545458013361 in pocket 2261461 10.1021/bi00487a007 1990 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 15506 7201 231 F143A, T144A Thermonuclease Staphylococcus aureus 4.6 0.77 Unknown NaH2PO4 10 mM 20.0 NaCl 100 mM CD GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 7.0 1STN 13.564545458013361, 9.712857246398926 in pocket 1620695 10.1002/prot.340130206 1992 ProTherm 17069 7976 231 F143W, W222A Thermonuclease Staphylococcus aureus 0.63 Unknown Phosphate 25.0 Fluorescence GdnHCl 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 9.0 1STN 13.564545458013361, 22.261428696768625 in pocket 20688426 10.1016/j.bpc.2010.07.001 2010 ProTherm 17071 7976 231 F143W, W222A Thermonuclease Staphylococcus aureus 0.55 Unknown Phosphate 25.0 CD GdnHCl 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 9.0 1STN 13.564545458013361, 22.261428696768625 in pocket 20688426 10.1016/j.bpc.2010.07.001 2010 ProTherm 17073 7976 231 F143W, W222A Thermonuclease Staphylococcus aureus 0.12 Unknown Tris-HCl 25 mM 25.0 Calcium chloride 10 mM Fluorescence Activity 8.8 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 9.0 1STN 13.564545458013361, 22.261428696768625 in pocket 20688426 10.1016/j.bpc.2010.07.001 2010 ProTherm 2413 1249 231 T144S Thermonuclease Staphylococcus aureus 70.0 -9.0 Unknown 43.7 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 2508 1249 231 T144S Thermonuclease Staphylococcus aureus 69.0 -8.3 Unknown 44.7 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm STRUM_Q306.csv, STRUM_Q3421.csv, AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S499.csv 13515 1249 231 T144S Thermonuclease Staphylococcus aureus 0.5 2.1 3.5 1.05 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 7577991 10.1021/bi00042a029 1995 ProTherm SAAFEC_S1262.csv 2421 1257 231 T144V Thermonuclease Staphylococcus aureus 65.0 2.2 Unknown 54.9 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, M47andM8_S1810.csv 2474 1257 231 T144V Thermonuclease Staphylococcus aureus 66.0 2.3 Unknown 55.0 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 2516 1257 231 T144V Thermonuclease Staphylococcus aureus 74.0 0.9 Unknown 53.9 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 13523 1257 231 T144V Thermonuclease Staphylococcus aureus 0.89 0.2 5.4 0.91 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 7577991 10.1021/bi00042a029 1995 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 2429 1265 231 T144C Thermonuclease Staphylococcus aureus 72.0 -4.6 Unknown 48.1 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, PoPMuSiC-2.0_S2648.csv, SVM-WIN31_SVM-3D12_S499.csv, STRUM_Q3421.csv, Broom_S605.csv 2524 1265 231 T144C Thermonuclease Staphylococcus aureus 71.0 -3.5 Unknown 49.5 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm Broom_S605.csv, EASE-MM_S238.csv, PON-TStab_dataset.csv, PoPMuSiC-2.0_S2648.csv 13531 1265 231 T144C Thermonuclease Staphylococcus aureus 0.68 1.1 4.5 0.98 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 7577991 10.1021/bi00042a029 1995 ProTherm SAAFEC_S1262.csv 2436 1272 231 T144I Thermonuclease Staphylococcus aureus 60.0 -3.9 Unknown 49.8 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, EASE-MM_S543.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 2468 1272 231 T144I Thermonuclease Staphylococcus aureus 60.0 -2.9 Unknown 49.8 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PoPMuSiC-2.0_S2648.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 2531 1272 231 T144I Thermonuclease Staphylococcus aureus 61.0 -2.5 Unknown 50.5 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm Broom_S605.csv, STRUM_Q3421.csv, EASE-MM_S238.csv, PoPMuSiC-2.0_S2648.csv 12782 1272 231 T144I Thermonuclease Staphylococcus aureus 0.72 1.7 3.7 5.19 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv 2464 1300 231 T144A Thermonuclease Staphylococcus aureus 57.0 -7.0 Unknown 45.7 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm Broom_S605.csv 2559 1300 231 T144A Thermonuclease Staphylococcus aureus 60.0 -8.1 Unknown 44.9 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S499.csv, PoPMuSiC-2.0_S2648.csv 13094 1300 231 T144A Thermonuclease Staphylococcus aureus 0.51 2.4 3.1 0.88 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13133 1300 231 T144A Thermonuclease Staphylococcus aureus -2.4 0.92 yes Na2HPO4 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 2381904 10.1002/prot.340070402 1990 ProTherm 2465 1301 231 T144F Thermonuclease Staphylococcus aureus 77.0 0.5 Unknown 53.2 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm M47andM8_S1810.csv, M47andM8_S2760.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, EASE-MM_S1676.csv, HotMuSiC_S1626.csv 2560 1301 231 T144F Thermonuclease Staphylococcus aureus 65.0 -0.4 Unknown 52.6 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm Broom_S605.csv, STRUM_Q306.csv, STRUM_Q3421.csv, AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, SVM-WIN31_SVM-3D12_S499.csv 2466 1302 231 T144G Thermonuclease Staphylococcus aureus 57.0 -15.8 Unknown 36.9 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 2561 1302 231 T144G Thermonuclease Staphylococcus aureus 56.0 -15.9 Unknown 37.1 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm Broom_S605.csv, STRUM_Q306.csv, STRUM_Q3421.csv 13093 1302 231 T144G Thermonuclease Staphylococcus aureus 0.27 3.5 2.0 1.08 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13134 1302 231 T144G Thermonuclease Staphylococcus aureus -3.4 1.09 yes Na2HPO4 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 2381904 10.1002/prot.340070402 1990 ProTherm 2467 1303 231 T144H Thermonuclease Staphylococcus aureus 79.0 -8.2 Unknown 44.5 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv 2562 1303 231 T144H Thermonuclease Staphylococcus aureus 68.0 -8.0 Unknown 45.0 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm Broom_S605.csv, STRUM_Q306.csv, STRUM_Q3421.csv 2469 1304 231 T144K Thermonuclease Staphylococcus aureus 52.0 -17.5 Unknown 35.2 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1925.csv, AUTOMUTE_S1962.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 2563 1304 231 T144K Thermonuclease Staphylococcus aureus 50.0 -18.2 Unknown 34.8 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm Broom_S605.csv, STRUM_Q306.csv, STRUM_Q3421.csv 2470 1305 231 T144L Thermonuclease Staphylococcus aureus 61.0 -4.4 Unknown 48.3 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv 2564 1305 231 T144L Thermonuclease Staphylococcus aureus 61.0 -5.3 Unknown 47.7 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 2471 1306 231 T144M Thermonuclease Staphylococcus aureus 58.0 -1.3 Unknown 51.4 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1925.csv, AUTOMUTE_S1962.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 2565 1306 231 T144M Thermonuclease Staphylococcus aureus 69.0 -2.3 Unknown 50.7 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1925.csv, AUTOMUTE_S1962.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 2472 1307 231 T144N Thermonuclease Staphylococcus aureus 53.0 -16.7 Unknown 36.0 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1925.csv, AUTOMUTE_S1962.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 2566 1307 231 T144N Thermonuclease Staphylococcus aureus 53.0 -15.9 Unknown 37.1 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 2473 1308 231 T144Q Thermonuclease Staphylococcus aureus 52.0 -13.5 Unknown 39.2 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 2567 1308 231 T144Q Thermonuclease Staphylococcus aureus 69.0 -12.4 Unknown 40.6 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv 13208 6211 231 T144E Thermonuclease Staphylococcus aureus 1.5 2.5 7.0 4.6 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 3.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13209 6211 231 T144E Thermonuclease Staphylococcus aureus 1.7 3.2 8.6 5.2 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13210 6211 231 T144E Thermonuclease Staphylococcus aureus 1.4 4.2 7.5 5.3 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 6.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13211 6211 231 T144E Thermonuclease Staphylococcus aureus 1.0 6.3 5.6 5.5 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13212 6211 231 T144E Thermonuclease Staphylococcus aureus 0.9 6.7 4.9 5.5 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 9.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13213 6211 231 T144E Thermonuclease Staphylococcus aureus 0.7 6.5 3.8 5.9 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 9.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.712857246398926 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 15536 7227 231 T144A, V148L Thermonuclease Staphylococcus aureus 2.4 0.68 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 8.0 1STN 9.712857246398926, 13.088571275983538 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15537 7228 231 T144A, G170V Thermonuclease Staphylococcus aureus 3.2 0.69 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 6.0 1STN 9.712857246398926, 8.599999904632568 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15554 7244 231 T144G, G170V Thermonuclease Staphylococcus aureus 3.66 0.96 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 6.0 1STN 9.712857246398926, 8.599999904632568 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 12872 5998 231 K145A Thermonuclease Staphylococcus aureus 0.78 0.5 5.1 0.95 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 17.81111102634006 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 12873 5999 231 K145G Thermonuclease Staphylococcus aureus 0.56 1.5 4.1 1.05 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 17.81111102634006 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12928 6051 231 K145E Thermonuclease Staphylococcus aureus 0.6 1.5 3.9 6.6 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 17.81111102634006 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv 12929 6052 231 K145Q Thermonuclease Staphylococcus aureus 0.7 1.0 4.4 6.2 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 17.81111102634006 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv 13345 6248 231 K145F Thermonuclease Staphylococcus aureus 0.58 2.0 3.5 0.93 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 17.81111102634006 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv 12874 6000 231 K146A Thermonuclease Staphylococcus aureus 0.83 -0.1 5.7 1.01 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 33.98444419436984 in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 12875 6001 231 K146G Thermonuclease Staphylococcus aureus 0.71 0.4 5.2 1.05 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 33.98444419436984 in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 12930 6053 231 K146E Thermonuclease Staphylococcus aureus 0.55 1.6 3.8 7.0 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 33.98444419436984 in pocket 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv 12931 6054 231 K146Q Thermonuclease Staphylococcus aureus 0.82 0.0 5.4 6.53 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 33.98444419436984 in pocket 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 13346 6249 231 K146F Thermonuclease Staphylococcus aureus 0.85 0.3 5.2 0.92 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 33.98444419436984 in pocket 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 2447 1283 231 M147F Thermonuclease Staphylococcus aureus 74.0 -5.8 Unknown 46.9 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 15.37374997138977 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm EASE-MM_S238.csv 2542 1283 231 M147F Thermonuclease Staphylococcus aureus 73.0 -5.7 Unknown 47.3 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 15.37374997138977 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm Broom_S605.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv 13347 1283 231 M147F Thermonuclease Staphylococcus aureus 0.58 1.6 3.9 1.03 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 15.37374997138977 in pocket 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv 12722 5880 231 M147I Thermonuclease Staphylococcus aureus 0.61 1.5 3.9 0.99 Unknown sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 15.37374997138977 in pocket 11438757 10.1093/protein/14.5.343 2001 ProTherm SAAFEC_S1262.csv 12725 5883 231 M147L Thermonuclease Staphylococcus aureus 0.72 0.8 4.6 0.98 Unknown sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 15.37374997138977 in pocket 11438757 10.1093/protein/14.5.343 2001 ProTherm SAAFEC_S1262.csv 13453 6318 231 M147A Thermonuclease Staphylococcus aureus 0.4 2.0 3.48 1.05 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 15.37374997138977 in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13454 6319 231 M147G Thermonuclease Staphylococcus aureus 0.1 4.6 0.88 1.18 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 15.37374997138977 in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 15508 7203 231 M147A, V148A Thermonuclease Staphylococcus aureus 4.5 1.15 Unknown NaH2PO4 10 mM 20.0 NaCl 100 mM CD GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0, 8.0 1STN 15.37374997138977, 13.088571275983538 in pocket 1620695 10.1002/prot.340130206 1992 ProTherm 214 108 231 V148L Thermonuclease Staphylococcus aureus 2.1 65.0 3.9 yes 55.3 phosphate 0.05 M NaCl 0.1 M DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 8518730 10.1002/pro.5560020408 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 220 108 231 V148L Thermonuclease Staphylococcus aureus 2.1 40.0 3.8 yes 50.8 phosphate 0.05 M NaCl 0.1 M DSC Thermal 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 8518730 10.1002/pro.5560020408 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 2992 108 231 V148L Thermonuclease Staphylococcus aureus 2.37 82.54 5.7 yes 59.8 Sodium phosphate 20 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 8069224 10.1002/pro.5560030610 1994 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, PON-TStab_dataset.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, AUTOMUTE_S1749.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S1791.csv 3033 108 231 V148L Thermonuclease Staphylococcus aureus 82.5 5.7 yes 3.0 59.8 Sodium phosphate 20 mM NaCl 100 mM DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 8075087 10.1021/bi00201a035 1994 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, Broom_S605.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv, STRUM_Q3421.csv 3034 108 231 V148L Thermonuclease Staphylococcus aureus 82.5 yes 3.0 54.7 Sodium phosphate 20 mM NaCl 100 mM DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 8075087 10.1021/bi00201a035 1994 ProTherm AUTOMUTE_S1962.csv, Broom_S605.csv, Saraboji_S2204.csv 7604 108 231 V148L Thermonuclease Staphylococcus aureus 2.1 -0.8 yes phosphate 0.05 M 51.4 NaCl 0.1 M DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 8518730 10.1002/pro.5560020408 1993 ProTherm capriotti_S1615_map.csv 7791 108 231 V148L Thermonuclease Staphylococcus aureus 2.1 -0.6 yes phosphate 0.05 M 47.0 NaCl 0.1 M DSC Thermal 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 8518730 10.1002/pro.5560020408 1993 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 12704 108 231 V148L Thermonuclease Staphylococcus aureus 2.4 Unknown Bis-Tris 10 mM 21.0 Fluorescence Pressure 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 9792110 10.1002/pro.5560071020 1998 ProTherm 12733 108 231 V148L Thermonuclease Staphylococcus aureus 0.95 0.3 5.1 5.35 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 11705391 10.1021/bi011267t 2001 ProTherm 13120 108 231 V148L Thermonuclease Staphylococcus aureus 0.2 5.4 yes Na3PO4 25 mM 20.0 NaCl 0.1 M Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 3167015 10.1021/bi00413a027 1988 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 13294 108 231 V148L Thermonuclease Staphylococcus aureus 0.1 0.82 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 13311 108 231 V148L Thermonuclease Staphylococcus aureus 0.96 0.2 5.4 0.82 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 3449854 10.1002/prot.340010113 1986 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 13317 108 231 V148L Thermonuclease Staphylococcus aureus 2.99 -0.2 6.3 0.91 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence Urea 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 3449854 10.1002/prot.340010113 1986 ProTherm khan_protherm_data_mapped.csv 2383 1220 231 V148T Thermonuclease Staphylococcus aureus 84.0 -6.3 Unknown 46.4 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm PON-TStab_dataset.csv, PoPMuSiC-2.0_S2648.csv 2478 1220 231 V148T Thermonuclease Staphylococcus aureus 81.0 -5.7 Unknown 47.3 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm STRUM_Q3421.csv 13481 1220 231 V148T Thermonuclease Staphylococcus aureus 0.61 1.2 4.2 1.02 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 7577991 10.1021/bi00042a029 1995 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 13535 1220 231 V148T Thermonuclease Staphylococcus aureus 0.61 1.4 4.2 1.02 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 7577991 10.1021/bi00042a029 1995 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 2391 1228 231 V148S Thermonuclease Staphylococcus aureus 68.0 -13.9 Unknown 38.8 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, HotMuSiC_S1626.csv 2486 1228 231 V148S Thermonuclease Staphylococcus aureus 66.0 -12.9 Unknown 40.1 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv 13490 1228 231 V148S Thermonuclease Staphylococcus aureus 0.37 3.1 2.5 1.04 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 7577991 10.1021/bi00042a029 1995 ProTherm SAAFEC_S1262.csv 2989 1594 231 V148W Thermonuclease Staphylococcus aureus 6.1 yes 59.5 Sodium phosphate,Sodium sulfate, 10 mM,10 mM, Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 8355268 10.1006/jmbi.1993.1425 1993 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 2994 1594 231 V148W Thermonuclease Staphylococcus aureus 2.27 66.99 -7.8 yes 46.3 Sodium phosphate 20 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 8069224 10.1002/pro.5560030610 1994 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3037 1594 231 V148W Thermonuclease Staphylococcus aureus 67.0 -7.8 yes 3.0 46.3 Sodium phosphate 20 mM NaCl 100 mM DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 8075087 10.1021/bi00201a035 1994 ProTherm AUTOMUTE_S1962.csv, Broom_S605.csv, Saraboji_S2204.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3038 1594 231 V148W Thermonuclease Staphylococcus aureus 67.0 yes 3.0 50.8 Sodium phosphate 20 mM NaCl 100 mM DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 8075087 10.1021/bi00201a035 1994 ProTherm 3509 1594 231 V148W Thermonuclease Staphylococcus aureus 42.8 -10.0 yes 43.1 PIPES 0.05 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 8672513 10.1021/bi9530090 1996 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 11356 1594 231 V148W Thermonuclease Staphylococcus aureus 0.34 1.3 3.87 Unknown phosphate 20 mM 25.0 CD GdnHCl 7.3 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 9636036 10.1021/bi971863g 1998 ProTherm 11357 1594 231 V148W Thermonuclease Staphylococcus aureus 0.42 2.26 5.32 Unknown 3.0 phosphate 20 mM 25.0 CD GdnHCl 7.3 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 9636036 10.1021/bi971863g 1998 ProTherm 11358 1594 231 V148W Thermonuclease Staphylococcus aureus 0.92 2.75 2.98 Unknown 3.0 phosphate 20 mM 25.0 CD GdnHCl 7.3 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 9636036 10.1021/bi971863g 1998 ProTherm 13305 1594 231 V148W Thermonuclease Staphylococcus aureus 0.35 3.01 2.32 6.6 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 8355268 10.1006/jmbi.1993.1425 1993 ProTherm SAAFEC_S983.csv 13308 1594 231 V148W Thermonuclease Staphylococcus aureus 0.74 3.36 1.66 2.45 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 8355268 10.1006/jmbi.1993.1425 1993 ProTherm 13477 1594 231 V148W Thermonuclease Staphylococcus aureus 4.02 1.3 3.87 yes PIPES 0.05 mM 20.0 CD GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 8672513 10.1021/bi9530090 1996 ProTherm 2993 1597 231 V148A Thermonuclease Staphylococcus aureus 1.97 59.33 -11.9 yes 42.2 Sodium phosphate 20 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 8069224 10.1002/pro.5560030610 1994 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3043 1597 231 V148A Thermonuclease Staphylococcus aureus 38.3 -14.5 yes 36.3 Sodium acetate 20 mM NaCl 100 mM DSC Thermal 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 8069223 10.1002/pro.5560030609 1994 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3044 1597 231 V148A Thermonuclease Staphylococcus aureus 53.8 -12.2 yes 41.2 Sodium acetate 20 mM NaCl 100 mM DSC Thermal 6.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 8069223 10.1002/pro.5560030609 1994 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3045 1597 231 V148A Thermonuclease Staphylococcus aureus 59.3 -11.9 yes 42.2 Sodium phosphate 20 mM NaCl 100 mM DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 8069223 10.1002/pro.5560030609 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3046 1597 231 V148A Thermonuclease Staphylococcus aureus 60.3 -11.1 yes 42.4 Sodium phosphate 20 mM NaCl 100 mM DSC Thermal 8.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 8069223 10.1002/pro.5560030609 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 12703 1597 231 V148A Thermonuclease Staphylococcus aureus 2.2 Unknown Bis-Tris 10 mM 21.0 Fluorescence Pressure 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 9792110 10.1002/pro.5560071020 1998 ProTherm 13426 1597 231 V148A Thermonuclease Staphylococcus aureus 0.4 2.2 3.28 1.1 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12702 5871 231 V148G Thermonuclease Staphylococcus aureus 2.0 Unknown Bis-Tris 10 mM 21.0 Fluorescence Pressure 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 9792110 10.1002/pro.5560071020 1998 ProTherm 13427 5871 231 V148G Thermonuclease Staphylococcus aureus 0.1 4.4 1.08 1.17 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12732 5890 231 V148I Thermonuclease Staphylococcus aureus 0.74 1.0 4.4 5.94 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv 12802 5942 231 V148M Thermonuclease Staphylococcus aureus 0.89 0.2 5.4 0.92 Unknown Tris-HCl 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 1920420 10.1016/0022-2836(91)80195-z 1991 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 12803 5942 231 V148M Thermonuclease Staphylococcus aureus 0.88 0.1 5.1 0.89 Unknown Tris-HCl 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 8.8 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 1920420 10.1016/0022-2836(91)80195-z 1991 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 12805 5942 231 V148M Thermonuclease Staphylococcus aureus 0.77 0.1 4.4 0.86 Unknown ethanolamine-HCl 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 9.6 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 1920420 10.1016/0022-2836(91)80195-z 1991 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 12804 5943 231 V148K Thermonuclease Staphylococcus aureus 0.0 5.2 0.0 1.24 Unknown Tris-HCl 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 8.8 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 1920420 10.1016/0022-2836(91)80195-z 1991 ProTherm SAAFEC_S1262.csv 12806 5943 231 V148K Thermonuclease Staphylococcus aureus 0.01 4.4 0.1 1.3 Unknown ethanolamine-HCl 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 9.6 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 13.088571275983538 in pocket 1920420 10.1016/0022-2836(91)80195-z 1991 ProTherm SAAFEC_S983.csv 14462 6711 231 V148L, G170V Thermonuclease Staphylococcus aureus 1.22 54.5 6.4 yes 57.8 phosphate 0.05 M NaCl 0.1 M DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 6.0 1STN 13.088571275983538, 8.599999904632568 in pocket 8518730 10.1002/pro.5560020408 1993 ProTherm 14464 6711 231 V148L, G170V Thermonuclease Staphylococcus aureus 0.97 25.3 10.9 yes 57.9 phosphate 0.05 M NaCl 0.1 M DSC Thermal 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 6.0 1STN 13.088571275983538, 8.599999904632568 in pocket 8518730 10.1002/pro.5560020408 1993 ProTherm 15064 6711 231 V148L, G170V Thermonuclease Staphylococcus aureus 1.22 -1.0 yes phosphate 0.05 M 47.0 NaCl 0.1 M DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 6.0 1STN 13.088571275983538, 8.599999904632568 in pocket 8518730 10.1002/pro.5560020408 1993 ProTherm 15066 6711 231 V148L, G170V Thermonuclease Staphylococcus aureus 0.97 -1.2 yes phosphate 0.05 M 47.0 NaCl 0.1 M DSC Thermal 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 6.0 1STN 13.088571275983538, 8.599999904632568 in pocket 8518730 10.1002/pro.5560020408 1993 ProTherm 15510 6711 231 V148L, G170V Thermonuclease Staphylococcus aureus 2.1 3.5 yes Na3PO4 25 mM 20.0 NaCl 0.1 M Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 6.0 1STN 13.088571275983538, 8.599999904632568 in pocket 3167015 10.1021/bi00413a027 1988 ProTherm 15538 6711 231 V148L, G170V Thermonuclease Staphylococcus aureus 2.0 0.57 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 6.0 1STN 13.088571275983538, 8.599999904632568 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15586 6711 231 V148L, G170V Thermonuclease Staphylococcus aureus 0.89 2.1 3.5 0.57 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 6.0 1STN 13.088571275983538, 8.599999904632568 in pocket 3449854 10.1002/prot.340010113 1986 ProTherm 15591 6711 231 V148L, G170V Thermonuclease Staphylococcus aureus 3.17 1.4 4.7 0.75 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence Urea 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 6.0 1STN 13.088571275983538, 8.599999904632568 in pocket 3449854 10.1002/prot.340010113 1986 ProTherm 14463 6712 231 V148L, G161S, G170V Thermonuclease Staphylococcus aureus 2.22 26.5 4.7 yes 56.1 phosphate 0.05 M NaCl 0.1 M DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 6.0, 6.0 1STN 13.088571275983538, 12.882500171661377, 8.599999904632568 in pocket 8518730 10.1002/pro.5560020408 1993 ProTherm 14465 6712 231 V148L, G161S, G170V Thermonuclease Staphylococcus aureus 1.78 12.3 7.3 yes 54.3 phosphate 0.05 M NaCl 0.1 M DSC Thermal 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 6.0, 6.0 1STN 13.088571275983538, 12.882500171661377, 8.599999904632568 in pocket 8518730 10.1002/pro.5560020408 1993 ProTherm 14678 6712 231 V148L, G161S, G170V Thermonuclease Staphylococcus aureus 3.5 yes 57.6 Sodium phosphate 20 mM NaCl 100 mM DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 6.0, 6.0 1STN 13.088571275983538, 12.882500171661377, 8.599999904632568 in pocket 7849061 10.1021/bi00006a025 1995 ProTherm 15065 6712 231 V148L, G161S, G170V Thermonuclease Staphylococcus aureus 2.22 -0.3 yes phosphate 0.05 M 47.0 NaCl 0.1 M DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 6.0, 6.0 1STN 13.088571275983538, 12.882500171661377, 8.599999904632568 in pocket 8518730 10.1002/pro.5560020408 1993 ProTherm 15067 6712 231 V148L, G161S, G170V Thermonuclease Staphylococcus aureus 1.78 -0.5 yes phosphate 0.05 M 47.0 NaCl 0.1 M DSC Thermal 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 6.0, 6.0 1STN 13.088571275983538, 12.882500171661377, 8.599999904632568 in pocket 8518730 10.1002/pro.5560020408 1993 ProTherm 15511 6712 231 V148L, G161S, G170V Thermonuclease Staphylococcus aureus 3.0 2.6 yes Na3PO4 25 mM 20.0 NaCl 0.1 M Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 6.0, 6.0 1STN 13.088571275983538, 12.882500171661377, 8.599999904632568 in pocket 3167015 10.1021/bi00413a027 1988 ProTherm 15587 6712 231 V148L, G161S, G170V Thermonuclease Staphylococcus aureus 0.76 3.0 2.6 0.51 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 6.0, 6.0 1STN 13.088571275983538, 12.882500171661377, 8.599999904632568 in pocket 3449854 10.1002/prot.340010113 1986 ProTherm 15592 6712 231 V148L, G161S, G170V Thermonuclease Staphylococcus aureus 2.61 3.4 2.7 0.57 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence Urea 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 6.0, 6.0 1STN 13.088571275983538, 12.882500171661377, 8.599999904632568 in pocket 3449854 10.1002/prot.340010113 1986 ProTherm 15585 7275 231 V148L, G161S Thermonuclease Staphylococcus aureus 0.56 3.3 2.3 0.61 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 6.0 1STN 13.088571275983538, 12.882500171661377 in pocket 3449854 10.1002/prot.340010113 1986 ProTherm 15590 7275 231 V148L, G161S Thermonuclease Staphylococcus aureus 1.88 3.6 2.5 0.7 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence Urea 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 6.0 1STN 13.088571275983538, 12.882500171661377 in pocket 3449854 10.1002/prot.340010113 1986 ProTherm 17165 8013 231 V148I, I174V, V181I Thermonuclease Staphylococcus aureus 0.75 0.5 4.9 6.53 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 7.0 1STN 13.088571275983538, 9.303750038146973, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17166 8014 231 V148L, I174V, V181I Thermonuclease Staphylococcus aureus 0.85 0.4 5.0 5.94 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 7.0 1STN 13.088571275983538, 9.303750038146973, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17167 8015 231 V148I, I174V, V181L Thermonuclease Staphylococcus aureus 0.65 0.9 4.5 6.86 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 7.0 1STN 13.088571275983538, 9.303750038146973, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17168 8016 231 V148L, I174V, V181L Thermonuclease Staphylococcus aureus 0.9 -0.1 5.5 6.14 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 7.0 1STN 13.088571275983538, 9.303750038146973, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17169 8017 231 V148L, I174L, V181L Thermonuclease Staphylococcus aureus 0.79 0.7 4.7 5.88 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 7.0 1STN 13.088571275983538, 9.303750038146973, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17170 8018 231 V148I, I174L, V181L Thermonuclease Staphylococcus aureus 0.53 2.1 3.3 6.2 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 7.0 1STN 13.088571275983538, 9.303750038146973, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17171 8019 231 V148L, I174L, V181I Thermonuclease Staphylococcus aureus 0.71 1.4 4.0 5.55 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 7.0 1STN 13.088571275983538, 9.303750038146973, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17172 8020 231 V148I, I174L, V181I Thermonuclease Staphylococcus aureus 0.57 2.1 3.3 5.74 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 7.0 1STN 13.088571275983538, 9.303750038146973, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17197 8045 231 V148I, I154L, I174L Thermonuclease Staphylococcus aureus 0.58 2.3 3.1 5.42 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 8.0 1STN 13.088571275983538, 10.5625, 9.303750038146973 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17198 8046 231 V148I, I154V, I174L Thermonuclease Staphylococcus aureus 0.5 2.0 3.4 6.79 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 8.0 1STN 13.088571275983538, 10.5625, 9.303750038146973 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17199 8047 231 V148L, I154L, I174L Thermonuclease Staphylococcus aureus 0.66 1.5 3.9 6.0 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 8.0 1STN 13.088571275983538, 10.5625, 9.303750038146973 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17200 8048 231 V148L, I154V, I174L Thermonuclease Staphylococcus aureus 0.65 1.3 4.1 6.27 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 8.0 1STN 13.088571275983538, 10.5625, 9.303750038146973 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17201 8049 231 V148I, I154L, I174V Thermonuclease Staphylococcus aureus 0.61 1.4 4.0 6.53 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 8.0 1STN 13.088571275983538, 10.5625, 9.303750038146973 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17202 8050 231 V148I, I154V, I174V Thermonuclease Staphylococcus aureus 0.59 1.4 4.0 6.79 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 8.0 1STN 13.088571275983538, 10.5625, 9.303750038146973 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17203 8051 231 V148L, I154L, I174V Thermonuclease Staphylococcus aureus 0.69 0.8 4.6 6.6 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 8.0 1STN 13.088571275983538, 10.5625, 9.303750038146973 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17204 8052 231 V148L, I154V, I174V Thermonuclease Staphylococcus aureus 0.75 0.5 4.9 6.6 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 8.0 1STN 13.088571275983538, 10.5625, 9.303750038146973 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17205 8053 231 V148I, I154L, V181L Thermonuclease Staphylococcus aureus 0.58 1.9 3.5 6.0 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 7.0 1STN 13.088571275983538, 10.5625, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17206 8054 231 V148I, I154V, V181L Thermonuclease Staphylococcus aureus 0.6 1.6 3.8 6.4 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 7.0 1STN 13.088571275983538, 10.5625, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17207 8055 231 V148L, I154L, V181L Thermonuclease Staphylococcus aureus 0.78 0.8 4.6 5.88 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 7.0 1STN 13.088571275983538, 10.5625, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17208 8056 231 V148L, I154V, V181L Thermonuclease Staphylococcus aureus 0.79 0.5 4.9 6.14 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 7.0 1STN 13.088571275983538, 10.5625, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17209 8057 231 V148I, I154L, V181I Thermonuclease Staphylococcus aureus 0.63 1.9 3.5 5.55 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 7.0 1STN 13.088571275983538, 10.5625, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17210 8058 231 V148I, I154V, V181I Thermonuclease Staphylococcus aureus 0.73 0.8 4.6 6.4 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 7.0 1STN 13.088571275983538, 10.5625, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17211 8059 231 V148L, I154L, V181I Thermonuclease Staphylococcus aureus 0.75 1.0 4.4 5.88 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 7.0 1STN 13.088571275983538, 10.5625, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17212 8060 231 V148L, I154V, V181I Thermonuclease Staphylococcus aureus 0.75 0.8 4.6 6.2 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 7.0 1STN 13.088571275983538, 10.5625, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17229 8077 231 V148I, I154V, I174V, V181I Thermonuclease Staphylococcus aureus 0.67 1.0 4.4 6.6 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 8.0, 7.0 1STN 13.088571275983538, 10.5625, 9.303750038146973, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17230 8078 231 V148I, I154V, I174V, V181L Thermonuclease Staphylococcus aureus 0.54 1.7 3.7 6.92 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 8.0, 7.0 1STN 13.088571275983538, 10.5625, 9.303750038146973, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17231 8079 231 V148I, I154V, I174L, V181I Thermonuclease Staphylococcus aureus 0.51 2.0 3.4 6.66 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 8.0, 7.0 1STN 13.088571275983538, 10.5625, 9.303750038146973, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17232 8080 231 V148I, I154V, I174L, V181L Thermonuclease Staphylococcus aureus 0.42 2.4 3.0 7.05 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 8.0, 7.0 1STN 13.088571275983538, 10.5625, 9.303750038146973, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17233 8081 231 V148I, I154L, I174V, V181I Thermonuclease Staphylococcus aureus 0.59 1.6 3.8 6.53 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 8.0, 7.0 1STN 13.088571275983538, 10.5625, 9.303750038146973, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17234 8082 231 V148I, I154L, I174V, V181L Thermonuclease Staphylococcus aureus 0.52 1.8 3.6 6.86 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 8.0, 7.0 1STN 13.088571275983538, 10.5625, 9.303750038146973, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17235 8083 231 V148I, I154L, I174L, V181I Thermonuclease Staphylococcus aureus 0.41 3.3 2.1 5.22 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 8.0, 7.0 1STN 13.088571275983538, 10.5625, 9.303750038146973, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17236 8084 231 V148I, I154L, I174L, V181L Thermonuclease Staphylococcus aureus 0.42 3.0 2.4 5.75 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 8.0, 7.0 1STN 13.088571275983538, 10.5625, 9.303750038146973, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17237 8085 231 V148L, I154V, I174V, V181I Thermonuclease Staphylococcus aureus 0.69 0.8 4.6 6.66 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 8.0, 7.0 1STN 13.088571275983538, 10.5625, 9.303750038146973, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17238 8086 231 V148L, I154V, I174V, V181L Thermonuclease Staphylococcus aureus 0.71 0.7 4.7 6.66 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 8.0, 7.0 1STN 13.088571275983538, 10.5625, 9.303750038146973, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17239 8087 231 V148L, I154V, I174L, V181I Thermonuclease Staphylococcus aureus 0.57 1.8 3.6 6.33 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 8.0, 7.0 1STN 13.088571275983538, 10.5625, 9.303750038146973, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17240 8088 231 V148L, I154V, I174L, V181L Thermonuclease Staphylococcus aureus 0.62 1.4 4.0 6.53 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 8.0, 7.0 1STN 13.088571275983538, 10.5625, 9.303750038146973, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17241 8089 231 V148L, I154L, I174V, V181I Thermonuclease Staphylococcus aureus 0.69 1.0 4.4 6.33 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 8.0, 7.0 1STN 13.088571275983538, 10.5625, 9.303750038146973, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17242 8090 231 V148L, I154L, I174V, V181L Thermonuclease Staphylococcus aureus 0.71 0.7 4.7 6.6 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 8.0, 7.0 1STN 13.088571275983538, 10.5625, 9.303750038146973, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17243 8091 231 V148L, I154L, I174L, V181I Thermonuclease Staphylococcus aureus 0.58 1.9 3.5 6.0 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 8.0, 7.0 1STN 13.088571275983538, 10.5625, 9.303750038146973, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17244 8092 231 V148L, I154L, I174L, V181L Thermonuclease Staphylococcus aureus 0.65 1.3 4.1 6.4 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 8.0, 7.0 1STN 13.088571275983538, 10.5625, 9.303750038146973, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17256 8104 231 V148L, I154L Thermonuclease Staphylococcus aureus 0.75 0.9 4.5 0.89 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0 1STN 13.088571275983538, 10.5625 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 17257 8105 231 V148L, I154V Thermonuclease Staphylococcus aureus 0.8 0.5 4.9 0.92 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0 1STN 13.088571275983538, 10.5625 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 17258 8106 231 V148I, I154V Thermonuclease Staphylococcus aureus 0.63 1.2 4.2 0.99 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0 1STN 13.088571275983538, 10.5625 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 17259 8107 231 V148I, I154L Thermonuclease Staphylococcus aureus 0.64 1.7 3.7 0.87 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0 1STN 13.088571275983538, 10.5625 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 17280 8128 231 V148I, I174L Thermonuclease Staphylococcus aureus 0.59 1.9 3.5 0.88 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0 1STN 13.088571275983538, 9.303750038146973 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 17281 8129 231 V148I, I174V Thermonuclease Staphylococcus aureus 0.69 0.7 4.7 1.0 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0 1STN 13.088571275983538, 9.303750038146973 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 17282 8130 231 V148L, I174L Thermonuclease Staphylococcus aureus 0.79 1.0 4.4 0.83 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0 1STN 13.088571275983538, 9.303750038146973 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 17283 8131 231 V148L, I174V Thermonuclease Staphylococcus aureus 0.89 -0.1 5.5 0.92 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0 1STN 13.088571275983538, 9.303750038146973 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 17284 8132 231 V148I, V181I Thermonuclease Staphylococcus aureus 0.8 0.7 4.7 0.88 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 7.0 1STN 13.088571275983538, 6.662857123783657 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 17285 8133 231 V148I, V181L Thermonuclease Staphylococcus aureus 0.7 1.3 4.1 0.86 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 7.0 1STN 13.088571275983538, 6.662857123783657 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 17286 8134 231 V148L, V181I Thermonuclease Staphylococcus aureus 0.89 0.6 4.8 0.81 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 7.0 1STN 13.088571275983538, 6.662857123783657 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 17287 8135 231 V148L, V181L Thermonuclease Staphylococcus aureus 0.97 0.0 5.4 0.84 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 7.0 1STN 13.088571275983538, 6.662857123783657 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 2448 1284 231 E149F Thermonuclease Staphylococcus aureus 80.0 -6.6 Unknown 46.1 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 20.093333350287544 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 2543 1284 231 E149F Thermonuclease Staphylococcus aureus 68.0 -5.0 Unknown 48.0 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 20.093333350287544 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv 13348 1284 231 E149F Thermonuclease Staphylococcus aureus 0.64 1.4 4.1 0.97 yes Sodium phosphate 25 mM 20.0 NaCl 600 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 20.093333350287544 in pocket 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv 12836 5966 231 E149A Thermonuclease Staphylococcus aureus 0.64 1.0 4.6 1.02 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 20.093333350287544 in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12837 5967 231 E149G Thermonuclease Staphylococcus aureus 0.64 0.9 4.7 1.04 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 20.093333350287544 in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12932 6055 231 E149Q Thermonuclease Staphylococcus aureus 0.72 0.5 4.9 6.8 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 20.093333350287544 in pocket 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 13054 6141 231 N150G Thermonuclease Staphylococcus aureus 0.77 0.5 5.0 0.96 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 25.1587495803833 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 13055 6142 231 N150A Thermonuclease Staphylococcus aureus 0.76 0.5 5.0 0.97 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 25.1587495803833 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 3007 1604 231 A151T Thermonuclease Staphylococcus aureus -13.7 yes 40.5 Sodium phosphate 20 mM NaCl 100 mM DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 15.82599983215332 in pocket 7849061 10.1021/bi00006a025 1995 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 13122 1604 231 A151T Thermonuclease Staphylococcus aureus 2.7 2.9 yes Na3PO4 25 mM 20.0 NaCl 0.1 M Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 15.82599983215332 in pocket 3167015 10.1021/bi00413a027 1988 ProTherm 13303 1604 231 A151T Thermonuclease Staphylococcus aureus 2.63 1.13 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 15.82599983215332 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm SAAFEC_S983.csv 13315 1604 231 A151T Thermonuclease Staphylococcus aureus 0.37 2.7 2.9 1.15 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 15.82599983215332 in pocket 3449854 10.1002/prot.340010113 1986 ProTherm 13321 1604 231 A151T Thermonuclease Staphylococcus aureus 1.22 3.9 3.2 1.11 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence Urea 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 15.82599983215332 in pocket 3449854 10.1002/prot.340010113 1986 ProTherm 13006 6095 231 A151G Thermonuclease Staphylococcus aureus 0.48 2.0 3.5 1.05 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 15.82599983215332 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13007 6096 231 A151V Thermonuclease Staphylococcus aureus 0.32 2.3 3.2 1.07 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 15.82599983215332 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm SAAFEC_S1262.csv 15524 7215 231 A151T, A172S Thermonuclease Staphylococcus aureus 4.7 1.3 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 8.0 1STN 15.82599983215332, 7.815999984741211 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15552 7242 231 E157V, A151T Thermonuclease Staphylococcus aureus 4.35 1.03 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 8.0 1STN 15.82599983215332, 12.881110933091906 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 2990 1595 231 K152W Thermonuclease Staphylococcus aureus -3.4 yes 50.0 Sodium phosphate,Sodium sulfate, 10 mM,10 mM, Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 18.135555479261612 in pocket 8355268 10.1006/jmbi.1993.1425 1993 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, PON-TStab_dataset.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 13306 1595 231 K152W Thermonuclease Staphylococcus aureus 0.73 0.84 4.49 6.17 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 18.135555479261612 in pocket 8355268 10.1006/jmbi.1993.1425 1993 ProTherm 13309 1595 231 K152W Thermonuclease Staphylococcus aureus 0.75 0.15 4.87 6.49 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM CD GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 18.135555479261612 in pocket 8355268 10.1006/jmbi.1993.1425 1993 ProTherm 4257 2164 231 K152C Thermonuclease Staphylococcus aureus -2.8 yes 50.2 Sodium phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 18.135555479261612 in pocket 8580845 10.1002/pro.5560041211 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 13606 2164 231 K152C Thermonuclease Staphylococcus aureus 0.77 0.5 5.0 6.48 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 18.135555479261612 in pocket 8580845 10.1002/pro.5560041211 1995 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 4265 2170 231 K152F Thermonuclease Staphylococcus aureus 0.0 yes 53.0 Sodium phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 18.135555479261612 in pocket 8580845 10.1002/pro.5560041211 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 13349 2170 231 K152F Thermonuclease Staphylococcus aureus 0.83 0.2 5.3 0.96 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 18.135555479261612 in pocket 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv 13614 2170 231 K152F Thermonuclease Staphylococcus aureus 0.85 0.0 5.5 6.54 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 18.135555479261612 in pocket 8580845 10.1002/pro.5560041211 1995 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 12876 6002 231 K152A Thermonuclease Staphylococcus aureus 0.77 0.1 5.5 1.04 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 18.135555479261612 in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 12877 6003 231 K152G Thermonuclease Staphylococcus aureus 0.7 0.5 5.1 1.05 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 18.135555479261612 in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 12933 6056 231 K152E Thermonuclease Staphylococcus aureus 0.79 0.4 5.0 6.34 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 18.135555479261612 in pocket 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 12934 6057 231 K152Q Thermonuclease Staphylococcus aureus 0.79 0.3 5.1 6.47 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 18.135555479261612 in pocket 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 12878 6004 231 K153A Thermonuclease Staphylococcus aureus 0.7 0.4 5.2 1.07 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 19.362222141689724 in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 12879 6005 231 K153G Thermonuclease Staphylococcus aureus 0.58 1.1 4.5 1.12 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 19.362222141689724 in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13350 6250 231 K153F Thermonuclease Staphylococcus aureus 0.84 0.0 5.5 1.0 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 19.362222141689724 in pocket 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 12748 5904 231 I154L Thermonuclease Staphylococcus aureus 0.78 0.2 5.2 6.67 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 10.5625 in pocket 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 12749 5905 231 I154M Thermonuclease Staphylococcus aureus 0.52 1.8 3.6 6.99 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 10.5625 in pocket 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv 13214 6212 231 I154E Thermonuclease Staphylococcus aureus 1.0 4.7 4.8 4.9 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 3.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 10.5625 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13215 6212 231 I154E Thermonuclease Staphylococcus aureus 1.2 5.4 6.3 5.1 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 4.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 10.5625 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13216 6212 231 I154E Thermonuclease Staphylococcus aureus 1.0 6.5 5.2 5.5 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 6.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 10.5625 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13217 6212 231 I154E Thermonuclease Staphylococcus aureus 0.6 8.2 3.7 5.8 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 8.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 10.5625 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13218 6212 231 I154E Thermonuclease Staphylococcus aureus 0.5 8.5 3.1 5.6 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 9.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 10.5625 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13442 6309 231 I154V Thermonuclease Staphylococcus aureus 0.5 1.8 3.68 1.02 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 10.5625 in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13443 6310 231 I154A Thermonuclease Staphylococcus aureus 0.0 5.1 0.38 1.29 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 10.5625 in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 15517 7209 231 I154V, Y167A Thermonuclease Staphylococcus aureus 1.6 1.07 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 9.0 1STN 10.5625, 18.133333285649616 in tunnel in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15518 7210 231 I154V, Y195A Thermonuclease Staphylococcus aureus 0.94 1.1 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 9.0 1STN 10.5625, 33.795000076293945 in tunnel in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15574 7264 231 E157V, I154V Thermonuclease Staphylococcus aureus 3.12 0.9 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0 1STN 10.5625, 12.881110933091906 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15580 7270 231 G161S, I154V Thermonuclease Staphylococcus aureus 3.61 0.98 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 6.0 1STN 10.5625, 12.882500171661377 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 17173 8021 231 I154V, I174V, V181I Thermonuclease Staphylococcus aureus 0.56 1.4 4.0 7.18 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 7.0 1STN 10.5625, 9.303750038146973, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17174 8022 231 I154L, I174V, V181I Thermonuclease Staphylococcus aureus 0.68 0.7 4.7 6.86 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 7.0 1STN 10.5625, 9.303750038146973, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17175 8023 231 I154V, I174V, V181L Thermonuclease Staphylococcus aureus 0.47 2.0 3.4 7.25 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 7.0 1STN 10.5625, 9.303750038146973, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17176 8024 231 I154L, I174V, V181L Thermonuclease Staphylococcus aureus 0.63 1.1 4.3 6.86 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 7.0 1STN 10.5625, 9.303750038146973, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17177 8025 231 I154L, I174L, V181L Thermonuclease Staphylococcus aureus 0.6 1.4 4.0 6.79 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 7.0 1STN 10.5625, 9.303750038146973, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17178 8026 231 I154V, I174L, V181L Thermonuclease Staphylococcus aureus 0.41 2.4 3.0 7.38 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 7.0 1STN 10.5625, 9.303750038146973, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17179 8027 231 I154L, I174L, V181I Thermonuclease Staphylococcus aureus 0.65 1.4 4.0 6.2 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 7.0 1STN 10.5625, 9.303750038146973, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17180 8028 231 I154V, I174L, V181I Thermonuclease Staphylococcus aureus 0.47 2.1 3.3 7.05 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0, 7.0 1STN 10.5625, 9.303750038146973, 6.662857123783657 in pocket 11705393 10.1021/bi011269d 2001 ProTherm 17288 8136 231 I154L, I174L Thermonuclease Staphylococcus aureus 0.74 0.7 4.7 0.94 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0 1STN 10.5625, 9.303750038146973 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 17289 8137 231 I154L, I174V Thermonuclease Staphylococcus aureus 0.69 0.7 4.7 1.01 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0 1STN 10.5625, 9.303750038146973 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 17290 8138 231 I154V, I174L Thermonuclease Staphylococcus aureus 0.51 1.8 3.6 1.05 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0 1STN 10.5625, 9.303750038146973 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 17291 8139 231 I154V, I174V Thermonuclease Staphylococcus aureus 0.54 1.7 3.7 1.03 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0 1STN 10.5625, 9.303750038146973 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 17292 8140 231 I154L, V181I Thermonuclease Staphylococcus aureus 0.76 0.5 4.9 0.97 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 7.0 1STN 10.5625, 6.662857123783657 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 17293 8141 231 I154L, V181L Thermonuclease Staphylococcus aureus 0.71 0.8 4.6 0.99 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 7.0 1STN 10.5625, 6.662857123783657 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 17294 8142 231 I154V, V181I Thermonuclease Staphylococcus aureus 0.61 1.2 4.2 1.05 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 7.0 1STN 10.5625, 6.662857123783657 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 17295 8143 231 I154V, V181L Thermonuclease Staphylococcus aureus 0.53 1.7 3.7 1.03 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 7.0 1STN 10.5625, 6.662857123783657 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 639 375 231 E155G Thermonuclease Staphylococcus aureus 65.6 -15.2 Unknown 36.8 phosphate DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 14.42777771419949 in pocket 11598114 10.1074/jbc.M106620200 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 12839 375 231 E155G Thermonuclease Staphylococcus aureus 0.39 2.7 2.9 1.03 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 14.42777771419949 in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 2449 1285 231 E155F Thermonuclease Staphylococcus aureus 87.0 -5.3 Unknown 47.4 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 14.42777771419949 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 2544 1285 231 E155F Thermonuclease Staphylococcus aureus 79.0 -4.2 Unknown 48.8 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 14.42777771419949 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv 13351 1285 231 E155F Thermonuclease Staphylococcus aureus 0.73 1.1 4.4 0.92 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 14.42777771419949 in pocket 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv 12838 5968 231 E155A Thermonuclease Staphylococcus aureus 0.59 1.2 4.2 1.01 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 14.42777771419949 in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13135 5968 231 E155A Thermonuclease Staphylococcus aureus -1.6 1.0 yes Na2HPO4 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 14.42777771419949 in pocket 2381904 10.1002/prot.340070402 1990 ProTherm 12935 6058 231 E155K Thermonuclease Staphylococcus aureus 0.51 2.1 3.3 6.6 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 14.42777771419949 in pocket 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv 12936 6059 231 E155Q Thermonuclease Staphylococcus aureus 0.73 0.7 4.7 6.47 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 14.42777771419949 in pocket 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv 15507 7202 231 E155A, V156A Thermonuclease Staphylococcus aureus 5.2 0.98 Unknown NaH2PO4 10 mM 20.0 NaCl 100 mM CD GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0, 7.0 1STN 14.42777771419949, 12.14999989100865 in pocket 1620695 10.1002/prot.340130206 1992 ProTherm 15686 7325 231 E155G, D159G Thermonuclease Staphylococcus aureus -0.7 45.0 -22.0 Unknown 30.0 phosphate DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0, 9.0 1STN 14.42777771419949, 14.3125 in pocket 11598114 10.1074/jbc.M106620200 2001 ProTherm 15687 7326 231 E155G, E157G Thermonuclease Staphylococcus aureus -0.8 34.3 -24.5 Unknown 27.5 phosphate DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0, 8.0 1STN 14.42777771419949, 12.881110933091906 in pocket 11598114 10.1074/jbc.M106620200 2001 ProTherm 15689 7328 231 E155G, E157G, D159G Thermonuclease Staphylococcus aureus -1.3 29.4 -26.9 Unknown 25.1 phosphate DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0, 8.0, 9.0 1STN 14.42777771419949, 12.881110933091906, 14.3125 in pocket 11598114 10.1074/jbc.M106620200 2001 ProTherm 2384 1221 231 V156T Thermonuclease Staphylococcus aureus 64.0 -18.3 Unknown 34.4 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.14999989100865 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm EASE-MM_S1676.csv, PON-TStab_dataset.csv, HotMuSiC_S1626.csv, PoPMuSiC-2.0_S2648.csv 2479 1221 231 V156T Thermonuclease Staphylococcus aureus 62.0 -16.9 Unknown 36.1 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.14999989100865 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm Broom_S605.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, STRUM_Q3421.csv, EASE-MM_S1676.csv, AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 13482 1221 231 V156T Thermonuclease Staphylococcus aureus 0.24 3.8 1.8 1.14 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.14999989100865 in pocket 7577991 10.1021/bi00042a029 1995 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12734 5891 231 V156I Thermonuclease Staphylococcus aureus 0.51 1.8 3.6 7.01 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.14999989100865 in pocket 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv 12735 5892 231 V156L Thermonuclease Staphylococcus aureus 0.66 1.2 4.2 6.35 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.14999989100865 in pocket 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv 13219 6213 231 V156E Thermonuclease Staphylococcus aureus 0.9 5.4 4.1 4.7 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 3.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.14999989100865 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13220 6213 231 V156E Thermonuclease Staphylococcus aureus 1.0 6.1 5.7 5.5 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.14999989100865 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13221 6213 231 V156E Thermonuclease Staphylococcus aureus 0.8 6.8 4.9 5.8 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 6.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.14999989100865 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm SAAFEC_S983.csv 13222 6213 231 V156E Thermonuclease Staphylococcus aureus 0.5 9.2 2.7 5.5 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.14999989100865 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13223 6213 231 V156E Thermonuclease Staphylococcus aureus 0.4 9.4 2.1 5.2 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 9.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.14999989100865 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13224 6213 231 V156E Thermonuclease Staphylococcus aureus 0.2 9.1 1.2 5.4 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 9.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.14999989100865 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13428 6296 231 V156A Thermonuclease Staphylococcus aureus 0.3 3.1 2.38 1.13 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.14999989100865 in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13491 6336 231 V156S Thermonuclease Staphylococcus aureus 0.02 5.4 0.2 1.06 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.14999989100865 in pocket 7577991 10.1021/bi00042a029 1995 ProTherm SAAFEC_S1262.csv 3008 1605 231 E157A Thermonuclease Staphylococcus aureus -5.6 yes 48.5 Sodium phosphate 20 mM NaCl 100 mM DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 12.881110933091906 in pocket 7849061 10.1021/bi00006a025 1995 ProTherm Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 11072 1605 231 E157A Thermonuclease Staphylococcus aureus 2.1 5.0 Unknown Sodium acetate 50 mM 25.0 NaCl 100 mM Fluorescence GdnHCl 5.6 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 12.881110933091906 in pocket 10467101 10.1038/12338 1999 ProTherm 11073 1605 231 E157A Thermonuclease Staphylococcus aureus 2.0 4.3 Unknown Sodium acetate 50 mM 25.0 NaCl 100 mM Fluorescence GdnHCl 5.2 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 12.881110933091906 in pocket 10467101 10.1038/12338 1999 ProTherm 12840 1605 231 E157A Thermonuclease Staphylococcus aureus 0.62 2.2 3.4 0.78 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 12.881110933091906 in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13541 1605 231 E157A Thermonuclease Staphylococcus aureus 3.3 5.3 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 12.881110933091906 in pocket 10467101 10.1038/12338 1999 ProTherm 3009 1606 231 E157G Thermonuclease Staphylococcus aureus -15.2 yes 38.9 Sodium phosphate 20 mM NaCl 100 mM DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 12.881110933091906 in pocket 7849061 10.1021/bi00006a025 1995 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 12841 1606 231 E157G Thermonuclease Staphylococcus aureus 0.31 3.5 2.1 0.93 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 12.881110933091906 in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 3041 1619 231 E157V Thermonuclease Staphylococcus aureus 69.9 -6.6 yes 3.0 47.5 Sodium phosphate 20 mM NaCl 100 mM DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 12.881110933091906 in pocket 8075087 10.1021/bi00201a035 1994 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, Broom_S605.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3042 1619 231 E157V Thermonuclease Staphylococcus aureus 69.9 yes 3.0 60.8 Sodium phosphate 20 mM NaCl 100 mM DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 12.881110933091906 in pocket 8075087 10.1021/bi00201a035 1994 ProTherm AUTOMUTE_S1962.csv, Broom_S605.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 13295 1619 231 E157V Thermonuclease Staphylococcus aureus 2.31 0.79 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 12.881110933091906 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm SAAFEC_S1262.csv 12937 6060 231 E157K Thermonuclease Staphylococcus aureus 0.49 2.3 3.1 6.27 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 12.881110933091906 in pocket 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv 12938 6061 231 E157Q Thermonuclease Staphylococcus aureus 0.74 0.7 4.7 6.27 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 12.881110933091906 in pocket 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv 15539 7229 231 E157V, G161S Thermonuclease Staphylococcus aureus 4.67 0.56 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 6.0 1STN 12.881110933091906, 12.882500171661377 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15540 7230 231 E157V, P199L Thermonuclease Staphylococcus aureus 1.61 0.78 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 7.0 1STN 12.881110933091906, 22.304285866873606 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15553 7243 231 E157V, A172S Thermonuclease Staphylococcus aureus 3.6 0.97 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0 1STN 12.881110933091906, 7.815999984741211 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15575 7265 231 E157V, Y167A Thermonuclease Staphylococcus aureus 2.51 0.82 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 9.0 1STN 12.881110933091906, 18.133333285649616 in tunnel in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15576 7266 231 E157V, I174V Thermonuclease Staphylococcus aureus 2.05 0.91 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 8.0 1STN 12.881110933091906, 9.303750038146973 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15577 7267 231 E157V, Y195A Thermonuclease Staphylococcus aureus 1.55 0.92 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 9.0 1STN 12.881110933091906, 33.795000076293945 in tunnel in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15578 7268 231 E157V, A212G Thermonuclease Staphylococcus aureus 3.4 0.74 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 4.0 1STN 12.881110933091906, 13.848000144958496 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15688 7327 231 E157G, D159G Thermonuclease Staphylococcus aureus -1.2 35.6 -20.0 Unknown 32.0 phosphate DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 9.0 1STN 12.881110933091906, 14.3125 in pocket 11598114 10.1074/jbc.M106620200 2001 ProTherm 13136 6196 231 F158A Thermonuclease Staphylococcus aureus -4.1 1.07 yes Na2HPO4 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 13.565454656427557 in pocket 2381904 10.1002/prot.340070402 1990 ProTherm 13470 6196 231 F158A Thermonuclease Staphylococcus aureus 0.2 4.0 1.48 1.11 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 13.565454656427557 in pocket 2261461 10.1021/bi00487a007 1990 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13137 6197 231 F158G Thermonuclease Staphylococcus aureus -4.7 1.14 yes Na2HPO4 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 13.565454656427557 in pocket 2381904 10.1002/prot.340070402 1990 ProTherm 13471 6197 231 F158G Thermonuclease Staphylococcus aureus 0.1 4.7 0.78 1.05 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 13.565454656427557 in pocket 2261461 10.1021/bi00487a007 1990 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 14714 6884 231 F158V, H206L Thermonuclease Staphylococcus aureus 52.6 -0.8 yes 47.0 Unknown NaCl 0.3 M NMR Thermal 5.21 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 4.0 1STN 13.565454656427557, 25.575000286102295 in pocket 2372535 10.1021/bi00471a003 1990 ProTherm 15112 6884 231 F158V, H206L Thermonuclease Staphylococcus aureus 0.0 0.0 1.4 yes Unknown 40.0 NaCl 0.3 M NMR Thermal 5.21 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 4.0 1STN 13.565454656427557, 25.575000286102295 in pocket 2372535 10.1021/bi00471a003 1990 ProTherm 15763 7374 231 F158W, W222H Thermonuclease Staphylococcus aureus 77.6 yes 56.6 sodium phosphate 25mM NaCl 50 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 9.0 1STN 13.565454656427557, 22.261428696768625 in pocket 15066439 10.1016/j.jmb.2004.02.044 2004 ProTherm 17299 7374 231 F158W, W222H Thermonuclease Staphylococcus aureus 1.0 5.1 yes sodium phosphate 25mM 20.0 NaCl 50 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 9.0 1STN 13.565454656427557, 22.261428696768625 in pocket 15066439 10.1016/j.jmb.2004.02.044 2004 ProTherm 640 376 231 D159G Thermonuclease Staphylococcus aureus 62.1 -8.1 Unknown 43.9 phosphate DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 14.3125 11598114 10.1074/jbc.M106620200 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 12819 376 231 D159G Thermonuclease Staphylococcus aureus 0.6 2.2 4.4 0.79 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 14.3125 8639591 10.1021/bi960171+ 1996 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13139 376 231 D159G Thermonuclease Staphylococcus aureus -2.2 0.83 yes Na2HPO4 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 14.3125 2381904 10.1002/prot.340070402 1990 ProTherm 13575 376 231 D159G Thermonuclease Staphylococcus aureus 0.6 2.2 3.2 0.79 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 14.3125 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 3039 1618 231 D159A Thermonuclease Staphylococcus aureus 65.6 -10.7 yes 3.0 43.4 Sodium phosphate 20 mM NaCl 100 mM DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 14.3125 8075087 10.1021/bi00201a035 1994 ProTherm AUTOMUTE_S1962.csv, Broom_S605.csv, Saraboji_S2204.csv, AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, HotMuSiC_S1626.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, STRUM_Q306.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3040 1618 231 D159A Thermonuclease Staphylococcus aureus 65.6 yes 3.0 72.6 Sodium phosphate 20 mM NaCl 100 mM DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 14.3125 8075087 10.1021/bi00201a035 1994 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 11074 1618 231 D159A Thermonuclease Staphylococcus aureus 2.0 5.1 Unknown Sodium acetate 50 mM 25.0 NaCl 100 mM Fluorescence GdnHCl 5.6 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 14.3125 10467101 10.1038/12338 1999 ProTherm 11075 1618 231 D159A Thermonuclease Staphylococcus aureus 2.3 4.5 Unknown Sodium acetate 50 mM 25.0 NaCl 100 mM Fluorescence GdnHCl 5.2 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 14.3125 10467101 10.1038/12338 1999 ProTherm 12818 1618 231 D159A Thermonuclease Staphylococcus aureus 0.45 3.1 2.5 0.76 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 14.3125 8639591 10.1021/bi960171+ 1996 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13138 1618 231 D159A Thermonuclease Staphylococcus aureus -3.2 0.78 yes Na2HPO4 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 14.3125 2381904 10.1002/prot.340070402 1990 ProTherm 13542 1618 231 D159A Thermonuclease Staphylococcus aureus 2.4 5.2 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 14.3125 10467101 10.1038/12338 1999 ProTherm 13574 1618 231 D159A Thermonuclease Staphylococcus aureus 0.45 3.1 2.3 0.75 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 14.3125 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12939 6062 231 D159K Thermonuclease Staphylococcus aureus 0.35 3.5 1.9 5.54 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 14.3125 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv 12940 6063 231 D159N Thermonuclease Staphylococcus aureus 0.44 2.9 2.5 5.74 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 14.3125 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv 4258 2165 231 K160C Thermonuclease Staphylococcus aureus 0.4 yes 53.4 Sodium phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 29.735555436876083 8580845 10.1002/pro.5560041211 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 13607 2165 231 K160C Thermonuclease Staphylococcus aureus 0.82 0.4 5.1 6.24 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 29.735555436876083 8580845 10.1002/pro.5560041211 1995 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 4266 2171 231 K160F Thermonuclease Staphylococcus aureus -0.5 yes 52.5 Sodium phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 29.735555436876083 8580845 10.1002/pro.5560041211 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 13615 2171 231 K160F Thermonuclease Staphylococcus aureus 0.84 -0.1 5.6 6.63 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 29.735555436876083 8580845 10.1002/pro.5560041211 1995 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 12880 6006 231 K160A Thermonuclease Staphylococcus aureus 0.74 0.6 5.0 0.97 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 29.735555436876083 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 12881 6007 231 K160G Thermonuclease Staphylococcus aureus 0.65 1.1 4.5 0.99 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 29.735555436876083 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12941 6064 231 K160E Thermonuclease Staphylococcus aureus 0.73 0.8 4.6 6.27 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 29.735555436876083 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv 12942 6065 231 K160Q Thermonuclease Staphylococcus aureus 0.79 0.1 5.3 6.67 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 29.735555436876083 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 215 109 231 G161S Thermonuclease Staphylococcus aureus 1.96 65.0 -7.6 yes 43.8 phosphate 0.05 M NaCl 0.1 M DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 12.882500171661377 in pocket 8518730 10.1002/pro.5560020408 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 221 109 231 G161S Thermonuclease Staphylococcus aureus 1.96 40.0 -8.5 yes 38.5 phosphate 0.05 M NaCl 0.1 M DSC Thermal 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 12.882500171661377 in pocket 8518730 10.1002/pro.5560020408 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3010 109 231 G161S Thermonuclease Staphylococcus aureus -4.4 yes 49.7 Sodium phosphate 20 mM NaCl 100 mM DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 12.882500171661377 in pocket 7849061 10.1021/bi00006a025 1995 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3440 109 231 G161S Thermonuclease Staphylococcus aureus 55.0 -9.5 yes 38.3 Unknown NaCl 0.3 M NMR Thermal 5.28 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 12.882500171661377 in pocket 2372535 10.1021/bi00471a003 1990 ProTherm EASE-MM_S1676.csv, AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S499.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7605 109 231 G161S Thermonuclease Staphylococcus aureus 1.96 1.3 yes phosphate 0.05 M 51.4 NaCl 0.1 M DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 12.882500171661377 in pocket 8518730 10.1002/pro.5560020408 1993 ProTherm capriotti_S1615_map.csv 7792 109 231 G161S Thermonuclease Staphylococcus aureus 1.96 1.2 yes phosphate 0.05 M 47.0 NaCl 0.1 M DSC Thermal 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 12.882500171661377 in pocket 8518730 10.1002/pro.5560020408 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 13140 109 231 G161S Thermonuclease Staphylococcus aureus -2.4 0.92 yes Na2HPO4 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 12.882500171661377 in pocket 2381904 10.1002/prot.340070402 1990 ProTherm 13297 109 231 G161S Thermonuclease Staphylococcus aureus 2.66 0.82 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 12.882500171661377 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm SAAFEC_S1262.csv 13312 109 231 G161S Thermonuclease Staphylococcus aureus 0.5 2.6 3.0 0.89 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 12.882500171661377 in pocket 3449854 10.1002/prot.340010113 1986 ProTherm 13318 109 231 G161S Thermonuclease Staphylococcus aureus 1.59 2.9 3.2 0.89 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence Urea 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 12.882500171661377 in pocket 3449854 10.1002/prot.340010113 1986 ProTherm 13044 6132 231 G161A Thermonuclease Staphylococcus aureus 0.51 2.4 3.1 0.87 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 12.882500171661377 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm SAAFEC_S1262.csv 13588 6132 231 G161A Thermonuclease Staphylococcus aureus 0.51 2.3 3.1 0.87 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 12.882500171661377 in pocket 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm SAAFEC_S1262.csv 13045 6133 231 G161V Thermonuclease Staphylococcus aureus 0.5 2.4 3.1 0.89 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 12.882500171661377 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm SAAFEC_S1262.csv 13296 6240 231 G161D Thermonuclease Staphylococcus aureus 2.28 0.87 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 12.882500171661377 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm SAAFEC_S1262.csv 14733 6896 231 G161S, H206L Thermonuclease Staphylococcus aureus yes 53.9 Bis-Tris 10 mM NMR Thermal 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 4.0 1STN 12.882500171661377, 25.575000286102295 in pocket 8756688 10.1021/bi960309o 1996 ProTherm 14734 6896 231 G161S, H206L Thermonuclease Staphylococcus aureus yes 43.1 Bis-Tris 10 mM NMR Thermal 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 4.0 1STN 12.882500171661377, 25.575000286102295 in pocket 8756688 10.1021/bi960309o 1996 ProTherm 15110 6896 231 G161S, H206L Thermonuclease Staphylococcus aureus 2.85 67.3 yes Bis-Tris 10 mM 40.0 NMR Thermal 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 4.0 1STN 12.882500171661377, 25.575000286102295 in pocket 8756688 10.1021/bi960309o 1996 ProTherm 15111 6896 231 G161S, H206L Thermonuclease Staphylococcus aureus 0.32 33.1 yes Bis-Tris 10 mM 40.0 NMR Thermal 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 4.0 1STN 12.882500171661377, 25.575000286102295 in pocket 8756688 10.1021/bi960309o 1996 ProTherm 15496 6896 231 G161S, H206L Thermonuclease Staphylococcus aureus 1.0 5.5 9.36 yes Bis-Tris 10 mM 21.5 Fluorescence GdnHCl 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 4.0 1STN 12.882500171661377, 25.575000286102295 in pocket 8756688 10.1021/bi960309o 1996 ProTherm 15497 6896 231 G161S, H206L Thermonuclease Staphylococcus aureus 0.73 4.49 10.45 yes Bis-Tris 10 mM 21.5 Fluorescence GdnHCl 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 4.0 1STN 12.882500171661377, 25.575000286102295 in pocket 8756688 10.1021/bi960309o 1996 ProTherm 15541 7231 231 G161S, P199L Thermonuclease Staphylococcus aureus 2.08 0.87 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 7.0 1STN 12.882500171661377, 22.304285866873606 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15542 7232 231 G161D, N200D Thermonuclease Staphylococcus aureus 2.58 0.85 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 8.0 1STN 12.882500171661377, 15.703750133514404 in tunnel in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15543 7233 231 G161S, N200D Thermonuclease Staphylococcus aureus 2.79 0.84 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 8.0 1STN 12.882500171661377, 15.703750133514404 in tunnel in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15581 7271 231 G161S, Y167A Thermonuclease Staphylococcus aureus 2.69 0.89 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 9.0 1STN 12.882500171661377, 18.133333285649616 in tunnel in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15582 7272 231 G161S, I174V Thermonuclease Staphylococcus aureus 2.55 0.93 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 8.0 1STN 12.882500171661377, 9.303750038146973 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15583 7273 231 G161S, Y195A Thermonuclease Staphylococcus aureus 2.22 0.93 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 9.0 1STN 12.882500171661377, 33.795000076293945 in tunnel in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 15584 7274 231 G161S, A212G Thermonuclease Staphylococcus aureus 3.68 0.76 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0, 4.0 1STN 12.882500171661377, 13.848000144958496 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 2450 1286 231 Q162F Thermonuclease Staphylococcus aureus 80.0 -1.6 Unknown 51.1 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 26.504444546169704 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 2545 1286 231 Q162F Thermonuclease Staphylococcus aureus 80.0 -1.3 Unknown 51.7 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 26.504444546169704 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv 13352 1286 231 Q162F Thermonuclease Staphylococcus aureus 0.76 0.7 4.8 0.96 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 26.504444546169704 in tunnel in pocket 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv 13066 6153 231 Q162G Thermonuclease Staphylococcus aureus 0.64 1.4 4.1 0.95 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 26.504444546169704 in tunnel in pocket 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13067 6154 231 Q162A Thermonuclease Staphylococcus aureus 0.81 0.1 5.4 0.97 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 26.504444546169704 in tunnel in pocket 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 12908 6033 231 R163A Thermonuclease Staphylococcus aureus 0.64 1.1 4.5 1.02 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 25.010908820412375 in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12909 6034 231 R163G Thermonuclease Staphylococcus aureus 0.52 2.2 3.4 0.92 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 25.010908820412375 in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 2414 1250 231 T164S Thermonuclease Staphylococcus aureus 79.0 -3.5 Unknown 49.2 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 15.16857133592878 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, Broom_S605.csv, Saraboji_S2204.csv, AUTOMUTE_S1925.csv, HotMuSiC_S1626.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 2509 1250 231 T164S Thermonuclease Staphylococcus aureus 81.0 -2.4 Unknown 50.6 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 15.16857133592878 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm STRUM_Q306.csv, STRUM_Q3421.csv 13516 1250 231 T164S Thermonuclease Staphylococcus aureus 0.71 0.7 4.9 1.02 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 15.16857133592878 in tunnel in pocket 7577991 10.1021/bi00042a029 1995 ProTherm SAAFEC_S1262.csv 2422 1258 231 T164V Thermonuclease Staphylococcus aureus 89.0 0.7 Unknown 53.4 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 15.16857133592878 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 2517 1258 231 T164V Thermonuclease Staphylococcus aureus 89.0 1.6 Unknown 54.6 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 15.16857133592878 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 13524 1258 231 T164V Thermonuclease Staphylococcus aureus 0.87 -0.2 5.8 0.99 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 15.16857133592878 in tunnel in pocket 7577991 10.1021/bi00042a029 1995 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 2430 1266 231 T164C Thermonuclease Staphylococcus aureus 87.0 -2.5 Unknown 50.2 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 15.16857133592878 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, SVM-WIN31_SVM-3D12_S499.csv, Broom_S605.csv, iPTREE-STAB_S1859.csv, PON-TStab_dataset.csv, STRUM_Q3421.csv, HotMuSiC_S1626.csv 2525 1266 231 T164C Thermonuclease Staphylococcus aureus 84.0 -1.2 Unknown 51.8 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 15.16857133592878 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, Broom_S605.csv, EASE-MM_S238.csv, PON-TStab_dataset.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv 13532 1266 231 T164C Thermonuclease Staphylococcus aureus 0.79 0.1 5.5 1.03 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 15.16857133592878 in tunnel in pocket 7577991 10.1021/bi00042a029 1995 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 2437 1273 231 T164I Thermonuclease Staphylococcus aureus 90.0 0.8 Unknown 53.5 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 15.16857133592878 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, EASE-MM_S543.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S2204.csv 2532 1273 231 T164I Thermonuclease Staphylococcus aureus 92.0 1.6 Unknown 54.6 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 15.16857133592878 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv 12783 1273 231 T164I Thermonuclease Staphylococcus aureus 0.9 -0.5 5.9 6.51 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 15.16857133592878 in tunnel in pocket 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 13095 6177 231 T164G Thermonuclease Staphylococcus aureus 0.5 2.0 3.5 1.01 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 15.16857133592878 in tunnel in pocket 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13096 6178 231 T164A Thermonuclease Staphylococcus aureus 0.67 0.9 4.6 1.01 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 15.16857133592878 in tunnel in pocket 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12820 5950 231 D165A Thermonuclease Staphylococcus aureus 0.27 3.8 1.8 0.89 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 13.31374990940094 in tunnel in pocket 8639591 10.1021/bi960171+ 1996 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13141 5950 231 D165A Thermonuclease Staphylococcus aureus -3.9 0.9 yes Na2HPO4 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 13.31374990940094 in tunnel in pocket 2381904 10.1002/prot.340070402 1990 ProTherm 12821 5951 231 D165G Thermonuclease Staphylococcus aureus 0.44 2.7 2.9 0.94 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 13.31374990940094 in tunnel in pocket 8639591 10.1021/bi960171+ 1996 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13142 5951 231 D165G Thermonuclease Staphylococcus aureus -2.8 0.93 yes Na2HPO4 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 13.31374990940094 in tunnel in pocket 2381904 10.1002/prot.340070402 1990 ProTherm 13353 6251 231 D165F Thermonuclease Staphylococcus aureus 0.06 5.2 0.3 0.88 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 13.31374990940094 in tunnel in pocket 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv 2451 1287 231 K166F Thermonuclease Staphylococcus aureus 89.0 -3.5 Unknown 49.2 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 24.933333502875435 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 2546 1287 231 K166F Thermonuclease Staphylococcus aureus 82.0 -2.4 Unknown 50.6 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 24.933333502875435 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm Broom_S605.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv 13354 1287 231 K166F Thermonuclease Staphylococcus aureus 0.74 0.9 4.6 0.95 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 24.933333502875435 in tunnel in pocket 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv 12882 6008 231 K166A Thermonuclease Staphylococcus aureus 0.8 -0.2 5.8 1.06 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 24.933333502875435 in tunnel in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 12883 6009 231 K166G Thermonuclease Staphylococcus aureus 0.73 0.3 5.3 1.05 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 24.933333502875435 in tunnel in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 12943 6066 231 K166E Thermonuclease Staphylococcus aureus 0.82 0.0 5.4 6.6 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 24.933333502875435 in tunnel in pocket 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 12944 6067 231 K166Q Thermonuclease Staphylococcus aureus 0.79 0.1 5.3 6.73 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 24.933333502875435 in tunnel in pocket 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 2395 1232 231 Y167F Thermonuclease Staphylococcus aureus 88.0 -1.3 Unknown 51.4 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 18.133333285649616 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm Broom_S605.csv, guerios_625_map.csv, HotMuSiC_S1626.csv, PoPMuSiC-2.0_S2648.csv, potapov_with_uniprot_mapping.csv, AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 2490 1232 231 Y167F Thermonuclease Staphylococcus aureus 82.0 0.3 Unknown 53.3 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 18.133333285649616 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm guerios_625_map.csv, PoPMuSiC-2.0_S2648.csv, potapov_with_uniprot_mapping.csv, STRUM_Q3421.csv, Broom_S605.csv 13355 1232 231 Y167F Thermonuclease Staphylococcus aureus 0.82 0.2 5.3 0.98 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 18.133333285649616 in tunnel in pocket 9578580 10.1021/bi9725069 1998 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13498 1232 231 Y167F Thermonuclease Staphylococcus aureus 0.83 0.0 5.6 1.01 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 18.133333285649616 in tunnel in pocket 7577991 10.1021/bi00042a029 1995 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 2401 1238 231 Y167L Thermonuclease Staphylococcus aureus 90.0 -0.7 Unknown 52.0 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 18.133333285649616 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm Broom_S605.csv, STRUM_Q3421.csv 2496 1238 231 Y167L Thermonuclease Staphylococcus aureus 85.0 -0.7 Unknown 52.3 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 18.133333285649616 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 13505 1238 231 Y167L Thermonuclease Staphylococcus aureus 0.8 0.1 5.5 1.02 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 18.133333285649616 in tunnel in pocket 7577991 10.1021/bi00042a029 1995 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 13460 6324 231 Y167A Thermonuclease Staphylococcus aureus 0.7 0.4 5.08 1.01 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 18.133333285649616 in tunnel in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 13461 6325 231 Y167G Thermonuclease Staphylococcus aureus 0.6 1.0 4.48 1.03 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 18.133333285649616 in tunnel in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 15519 7211 231 Y167A, Y195A Thermonuclease Staphylococcus aureus 0.23 1.04 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0, 9.0 1STN 18.133333285649616, 33.795000076293945 in tunnel in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 2452 1288 231 G168F Thermonuclease Staphylococcus aureus 72.0 -9.1 Unknown 43.6 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 11.667499780654907 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 2547 1288 231 G168F Thermonuclease Staphylococcus aureus 72.0 -8.5 Unknown 44.5 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 11.667499780654907 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv, Broom_S605.csv 13356 1288 231 G168F Thermonuclease Staphylococcus aureus 0.53 2.0 3.5 1.01 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 11.667499780654907 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv 13046 6134 231 G168A Thermonuclease Staphylococcus aureus 0.79 0.6 4.9 0.92 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 11.667499780654907 1610820 10.1021/bi00140a005 1992 ProTherm SAAFEC_S1262.csv 13562 6134 231 G168A Thermonuclease Staphylococcus aureus 0.79 0.5 4.9 0.92 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 11.667499780654907 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 13047 6135 231 G168V Thermonuclease Staphylococcus aureus 0.25 3.7 1.8 1.07 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 11.667499780654907 1610820 10.1021/bi00140a005 1992 ProTherm SAAFEC_S1262.csv 12910 6035 231 R169A Thermonuclease Staphylococcus aureus 0.7 0.9 4.7 0.99 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS active site 9.0 1STN 13.658181623979049 in tunnel in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12911 6036 231 R169G Thermonuclease Staphylococcus aureus 0.44 2.6 3.0 0.95 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS active site 9.0 1STN 13.658181623979049 in tunnel in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 216 110 231 G170V Thermonuclease Staphylococcus aureus 2.47 62.0 2.9 yes 54.3 phosphate 0.05 M NaCl 0.1 M DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 8.599999904632568 in pocket 8518730 10.1002/pro.5560020408 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 222 110 231 G170V Thermonuclease Staphylococcus aureus 2.47 35.0 3.6 yes 50.6 phosphate 0.05 M NaCl 0.1 M DSC Thermal 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 8.599999904632568 in pocket 8518730 10.1002/pro.5560020408 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3035 110 231 G170V Thermonuclease Staphylococcus aureus 81.1 4.3 yes 3.0 58.4 Sodium phosphate 20 mM NaCl 100 mM DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 8.599999904632568 in pocket 8075087 10.1021/bi00201a035 1994 ProTherm AUTOMUTE_S1962.csv, Broom_S605.csv, Saraboji_S2204.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3036 110 231 G170V Thermonuclease Staphylococcus aureus 81.1 yes 3.0 64.8 Sodium phosphate 20 mM NaCl 100 mM DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 8.599999904632568 in pocket 8075087 10.1021/bi00201a035 1994 ProTherm AUTOMUTE_S1962.csv, Broom_S605.csv, Saraboji_S2204.csv 7606 110 231 G170V Thermonuclease Staphylococcus aureus 2.47 -0.5 yes phosphate 0.05 M 51.4 NaCl 0.1 M DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 8.599999904632568 in pocket 8518730 10.1002/pro.5560020408 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 7793 110 231 G170V Thermonuclease Staphylococcus aureus 2.47 -0.6 yes phosphate 0.05 M 47.0 NaCl 0.1 M DSC Thermal 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 8.599999904632568 in pocket 8518730 10.1002/pro.5560020408 1993 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 13049 110 231 G170V Thermonuclease Staphylococcus aureus 0.86 0.9 4.6 0.78 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 8.599999904632568 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 13121 110 231 G170V Thermonuclease Staphylococcus aureus 1.0 4.6 yes Na3PO4 25 mM 20.0 NaCl 0.1 M Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 8.599999904632568 in pocket 3167015 10.1021/bi00413a027 1988 ProTherm SAAFEC_S1262.csv 13298 110 231 G170V Thermonuclease Staphylococcus aureus 0.9 0.78 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 8.599999904632568 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 13313 110 231 G170V Thermonuclease Staphylococcus aureus 0.86 1.0 4.6 0.78 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 8.599999904632568 in pocket 3449854 10.1002/prot.340010113 1986 ProTherm SAAFEC_S1262.csv 13319 110 231 G170V Thermonuclease Staphylococcus aureus 2.72 0.9 5.2 0.85 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence Urea 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 8.599999904632568 in pocket 3449854 10.1002/prot.340010113 1986 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 2991 1596 231 G170W Thermonuclease Staphylococcus aureus 4.8 yes 58.2 Sodium phosphate,Sodium sulfate, 10 mM,10 mM, Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 8.599999904632568 in pocket 8355268 10.1006/jmbi.1993.1425 1993 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, PON-TStab_dataset.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, PoPMuSiC-2.0_S2648.csv, AUTOMUTE_S1749.csv, M47andM8_S1810.csv, Saraboji_S1791.csv 3011 1596 231 G170W Thermonuclease Staphylococcus aureus 4.6 yes 58.7 Sodium phosphate 20 mM NaCl 100 mM DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 8.599999904632568 in pocket 7849061 10.1021/bi00006a025 1995 ProTherm Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1962.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 13307 1596 231 G170W Thermonuclease Staphylococcus aureus 0.92 1.22 4.11 4.46 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 8.599999904632568 in pocket 8355268 10.1006/jmbi.1993.1425 1993 ProTherm 13310 1596 231 G170W Thermonuclease Staphylococcus aureus 0.95 0.69 4.33 4.6 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM CD GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 8.599999904632568 in pocket 8355268 10.1006/jmbi.1993.1425 1993 ProTherm 13048 6136 231 G170A Thermonuclease Staphylococcus aureus 0.87 0.1 5.4 0.92 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 8.599999904632568 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 3441 1789 231 L171F Thermonuclease Staphylococcus aureus 43.1 -7.5 yes 40.3 Unknown NaCl 0.3 M NMR Thermal 5.38 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 8.788750052452087 in tunnel in pocket 2372535 10.1021/bi00471a003 1990 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S499.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8090 1789 231 L171F Thermonuclease Staphylococcus aureus 0.0 1.2 0.2 yes Unknown 40.0 NaCl 0.3 M NMR Thermal 5.38 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 8.788750052452087 in tunnel in pocket 2372535 10.1021/bi00471a003 1990 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 12767 5923 231 L171I Thermonuclease Staphylococcus aureus 0.67 1.1 4.3 6.49 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 8.788750052452087 in tunnel in pocket 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv 12768 5924 231 L171V Thermonuclease Staphylococcus aureus 0.6 1.4 4.0 6.69 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 8.788750052452087 in tunnel in pocket 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv 13415 6288 231 L171A Thermonuclease Staphylococcus aureus 0.4 2.6 2.88 1.0 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 8.788750052452087 in tunnel in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13416 6289 231 L171G Thermonuclease Staphylococcus aureus 0.3 3.2 2.28 0.96 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 8.788750052452087 in tunnel in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 217 111 231 A172S Thermonuclease Staphylococcus aureus 2.43 92.0 -10.7 yes 40.7 phosphate 0.05 M NaCl 0.1 M DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 7.815999984741211 in pocket 8518730 10.1002/pro.5560020408 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 223 111 231 A172S Thermonuclease Staphylococcus aureus 2.43 65.0 -13.5 yes 33.5 phosphate 0.05 M NaCl 0.1 M DSC Thermal 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 7.815999984741211 in pocket 8518730 10.1002/pro.5560020408 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7607 111 231 A172S Thermonuclease Staphylococcus aureus 2.43 2.5 yes phosphate 0.05 M 51.4 NaCl 0.1 M DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 7.815999984741211 in pocket 8518730 10.1002/pro.5560020408 1993 ProTherm capriotti_S1615_map.csv 7794 111 231 A172S Thermonuclease Staphylococcus aureus 2.43 2.6 yes phosphate 0.05 M 47.0 NaCl 0.1 M DSC Thermal 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 7.815999984741211 in pocket 8518730 10.1002/pro.5560020408 1993 ProTherm capriotti_S1615_map.csv 13143 111 231 A172S Thermonuclease Staphylococcus aureus -2.0 1.1 yes Na2HPO4 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 7.815999984741211 in pocket 2381904 10.1002/prot.340070402 1990 ProTherm 13304 111 231 A172S Thermonuclease Staphylococcus aureus 1.9 1.1 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 7.815999984741211 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 13316 111 231 A172S Thermonuclease Staphylococcus aureus 0.48 2.0 3.6 1.1 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 7.815999984741211 in pocket 3449854 10.1002/prot.340010113 1986 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, khan_protherm_data_mapped.csv, SAAFEC_S1262.csv 13322 111 231 A172S Thermonuclease Staphylococcus aureus 1.58 2.1 4.0 1.06 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence Urea 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 7.815999984741211 in pocket 3449854 10.1002/prot.340010113 1986 ProTherm 13008 6097 231 A172G Thermonuclease Staphylococcus aureus 0.53 2.0 3.5 0.96 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 7.815999984741211 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13009 6098 231 A172V Thermonuclease Staphylococcus aureus 0.84 0.2 5.3 0.92 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 7.815999984741211 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 13225 6214 231 A172E Thermonuclease Staphylococcus aureus 0.4 7.5 1.9 4.3 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 3.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 7.815999984741211 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13226 6214 231 A172E Thermonuclease Staphylococcus aureus 0.8 7.1 4.7 5.7 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 4.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 7.815999984741211 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13227 6214 231 A172E Thermonuclease Staphylococcus aureus 0.7 7.7 4.0 5.7 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 5.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 7.815999984741211 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm SAAFEC_S1262.csv 13228 6214 231 A172E Thermonuclease Staphylococcus aureus 0.6 8.6 3.3 5.4 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 8.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 7.815999984741211 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13229 6214 231 A172E Thermonuclease Staphylococcus aureus 0.6 8.2 3.3 5.7 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 9.1 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 7.815999984741211 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 2396 1233 231 Y173F Thermonuclease Staphylococcus aureus 60.0 -7.2 Unknown 45.5 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 8.31083333492279 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm HotMuSiC_S1626.csv, PoPMuSiC-2.0_S2648.csv, AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, Broom_S605.csv 2491 1233 231 Y173F Thermonuclease Staphylococcus aureus 59.0 -6.4 Unknown 46.6 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 8.31083333492279 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 13499 1233 231 Y173F Thermonuclease Staphylococcus aureus 0.51 2.4 3.2 0.94 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 8.31083333492279 in pocket 7577991 10.1021/bi00042a029 1995 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 2402 1239 231 Y173L Thermonuclease Staphylococcus aureus 50.0 -14.1 Unknown 38.6 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 8.31083333492279 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 2497 1239 231 Y173L Thermonuclease Staphylococcus aureus 50.0 -13.8 Unknown 39.2 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 8.31083333492279 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 13506 1239 231 Y173L Thermonuclease Staphylococcus aureus 0.27 3.9 1.7 0.96 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 8.31083333492279 in pocket 7577991 10.1021/bi00042a029 1995 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13144 6198 231 Y173S Thermonuclease Staphylococcus aureus -5.3 1.08 yes Na2HPO4 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 8.31083333492279 in pocket 2381904 10.1002/prot.340070402 1990 ProTherm 13230 6215 231 Y173E Thermonuclease Staphylococcus aureus 1.0 5.0 4.5 4.7 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 3.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 8.31083333492279 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13231 6215 231 Y173E Thermonuclease Staphylococcus aureus 1.2 5.4 6.3 5.3 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 4.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 8.31083333492279 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13232 6215 231 Y173E Thermonuclease Staphylococcus aureus 0.9 7.3 4.4 5.0 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 6.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 8.31083333492279 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13233 6215 231 Y173E Thermonuclease Staphylococcus aureus 0.6 8.7 3.2 5.2 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 8.31083333492279 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13234 6215 231 Y173E Thermonuclease Staphylococcus aureus 0.6 8.6 3.0 5.4 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 9.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 8.31083333492279 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13462 6326 231 Y173A Thermonuclease Staphylococcus aureus 0.0 5.3 0.18 1.01 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 8.31083333492279 in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12750 5906 231 I174L Thermonuclease Staphylococcus aureus 0.73 0.6 4.8 6.68 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 9.303750038146973 in pocket 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 12751 5907 231 I174M Thermonuclease Staphylococcus aureus 0.53 1.6 3.8 7.09 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 9.303750038146973 in pocket 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv 12752 5908 231 I174V Thermonuclease Staphylococcus aureus 0.75 0.4 5.0 6.68 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 9.303750038146973 in pocket 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 13444 5908 231 I174V Thermonuclease Staphylococcus aureus 0.7 0.5 4.98 1.01 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 9.303750038146973 in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13235 6216 231 I174E Thermonuclease Staphylococcus aureus 0.8 5.6 3.9 5.0 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 3.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 9.303750038146973 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13236 6216 231 I174E Thermonuclease Staphylococcus aureus 1.0 5.8 5.9 5.9 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 4.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 9.303750038146973 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13237 6216 231 I174E Thermonuclease Staphylococcus aureus 0.8 6.7 5.0 6.2 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 6.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 9.303750038146973 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13238 6216 231 I174E Thermonuclease Staphylococcus aureus 0.4 9.2 2.7 6.4 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 9.303750038146973 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13239 6216 231 I174E Thermonuclease Staphylococcus aureus 0.2 10.1 1.4 6.7 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 9.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 9.303750038146973 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13445 6311 231 I174A Thermonuclease Staphylococcus aureus 0.1 4.0 1.48 1.18 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 9.303750038146973 in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 17260 8108 231 I174L, V181I Thermonuclease Staphylococcus aureus 0.67 0.9 4.5 1.01 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 7.0 1STN 9.303750038146973, 6.662857123783657 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 17261 8109 231 I174L, V181L Thermonuclease Staphylococcus aureus 0.63 1.3 4.1 0.96 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 7.0 1STN 9.303750038146973, 6.662857123783657 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 17262 8110 231 I174V, V181I Thermonuclease Staphylococcus aureus 0.73 0.7 4.7 0.96 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 7.0 1STN 9.303750038146973, 6.662857123783657 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 17263 8111 231 I174V, V181L Thermonuclease Staphylococcus aureus 0.67 0.9 4.5 1.0 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0, 7.0 1STN 9.303750038146973, 6.662857123783657 in pocket 11705392 10.1021/bi011268l 2001 ProTherm 2397 1234 231 Y175F Thermonuclease Staphylococcus aureus 72.0 -7.8 Unknown 44.9 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 8.727499961853027 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 2492 1234 231 Y175F Thermonuclease Staphylococcus aureus 70.0 -6.6 Unknown 46.4 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 8.727499961853027 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm Broom_S605.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv 13500 1234 231 Y175F Thermonuclease Staphylococcus aureus 0.59 2.0 3.6 0.92 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 8.727499961853027 in pocket 7577991 10.1021/bi00042a029 1995 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13507 6340 231 Y175L Thermonuclease Staphylococcus aureus 0.15 4.5 1.1 1.07 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 8.727499961853027 in pocket 7577991 10.1021/bi00042a029 1995 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 17070 7977 231 Y175W, W222A Thermonuclease Staphylococcus aureus 0.64 Unknown Phosphate 25.0 Fluorescence GdnHCl 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 9.0 1STN 8.727499961853027, 22.261428696768625 in pocket 20688426 10.1016/j.bpc.2010.07.001 2010 ProTherm 17072 7977 231 Y175W, W222A Thermonuclease Staphylococcus aureus 0.5 Unknown Phosphate 25.0 CD GdnHCl 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 9.0 1STN 8.727499961853027, 22.261428696768625 in pocket 20688426 10.1016/j.bpc.2010.07.001 2010 ProTherm 17074 7977 231 Y175W, W222A Thermonuclease Staphylococcus aureus 0.09 Unknown Tris-HCl 25 mM 25.0 Calcium chloride 10 mM Fluorescence Activity 8.8 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 9.0 1STN 8.727499961853027, 22.261428696768625 in pocket 20688426 10.1016/j.bpc.2010.07.001 2010 ProTherm 13010 6099 231 A176G Thermonuclease Staphylococcus aureus 0.41 2.4 3.1 1.12 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 8.760000038146973 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13011 6100 231 A176V Thermonuclease Staphylococcus aureus 0.66 1.3 4.2 0.94 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 8.760000038146973 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm SAAFEC_S1262.csv 12822 5952 231 D177A Thermonuclease Staphylococcus aureus 0.28 3.3 2.3 1.13 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.697499990463257 in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13145 5952 231 D177A Thermonuclease Staphylococcus aureus -3.6 1.07 yes Na2HPO4 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.697499990463257 in pocket 2381904 10.1002/prot.340070402 1990 ProTherm 13552 5952 231 D177A Thermonuclease Staphylococcus aureus 0.28 3.3 2.1 1.13 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.697499990463257 in pocket 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12823 5953 231 D177G Thermonuclease Staphylococcus aureus 0.37 2.7 2.9 1.11 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.697499990463257 in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13146 5953 231 D177G Thermonuclease Staphylococcus aureus -3.1 1.03 yes Na2HPO4 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.697499990463257 in pocket 2381904 10.1002/prot.340070402 1990 ProTherm 13553 5953 231 D177G Thermonuclease Staphylococcus aureus 0.37 2.7 2.7 1.11 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.697499990463257 in pocket 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13357 6252 231 D177F Thermonuclease Staphylococcus aureus 0.06 5.3 0.2 0.59 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.697499990463257 in pocket 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv 2453 1289 231 G178F Thermonuclease Staphylococcus aureus 73.0 -10.7 Unknown 42.0 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.952500104904175 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 2548 1289 231 G178F Thermonuclease Staphylococcus aureus 73.0 -11.3 Unknown 41.7 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.952500104904175 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm Broom_S605.csv, STRUM_Q3421.csv 13358 1289 231 G178F Thermonuclease Staphylococcus aureus 0.51 3.0 2.5 0.75 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.952500104904175 in pocket 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv 13050 6137 231 G178A Thermonuclease Staphylococcus aureus 0.53 1.8 3.7 1.02 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.952500104904175 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm SAAFEC_S1262.csv 13563 6137 231 G178A Thermonuclease Staphylococcus aureus 0.53 1.7 3.7 1.02 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.952500104904175 in pocket 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm SAAFEC_S1262.csv 13051 6138 231 G178V Thermonuclease Staphylococcus aureus 0.25 3.7 1.8 1.08 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.952500104904175 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm SAAFEC_S1262.csv 12884 6010 231 K179A Thermonuclease Staphylococcus aureus 0.75 0.1 5.5 1.07 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 27.70666609870063 in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 12885 6011 231 K179G Thermonuclease Staphylococcus aureus 0.51 1.7 3.9 1.09 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 27.70666609870063 in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12945 6068 231 K179E Thermonuclease Staphylococcus aureus 0.77 0.6 4.8 6.2 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 27.70666609870063 in pocket 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 12946 6069 231 K179Q Thermonuclease Staphylococcus aureus 0.79 0.4 5.0 6.34 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 27.70666609870063 in pocket 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 13359 6253 231 K179F Thermonuclease Staphylococcus aureus 0.76 0.7 4.8 0.95 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 27.70666609870063 in pocket 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv 12723 5881 231 M180I Thermonuclease Staphylococcus aureus 0.15 4.4 1.0 1.02 Unknown sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.301250040531158 11438757 10.1093/protein/14.5.343 2001 ProTherm SAAFEC_S1262.csv 13455 6320 231 M180A Thermonuclease Staphylococcus aureus 0.1 4.6 0.88 0.75 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.301250040531158 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13456 6321 231 M180G Thermonuclease Staphylococcus aureus 0.1 4.5 0.98 0.88 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9.301250040531158 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 2385 1222 231 V181T Thermonuclease Staphylococcus aureus 68.0 -15.2 Unknown 37.5 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 6.662857123783657 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm EASE-MM_S1676.csv, PON-TStab_dataset.csv 2480 1222 231 V181T Thermonuclease Staphylococcus aureus 65.0 -13.8 Unknown 39.1 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 6.662857123783657 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm Broom_S605.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, EASE-MM_S1676.csv, STRUM_Q3421.csv 13483 1222 231 V181T Thermonuclease Staphylococcus aureus 0.32 3.3 2.3 1.07 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 6.662857123783657 in pocket 7577991 10.1021/bi00042a029 1995 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12736 5893 231 V181I Thermonuclease Staphylococcus aureus 0.81 0.2 5.2 6.4 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 6.662857123783657 in pocket 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 12737 5894 231 V181L Thermonuclease Staphylococcus aureus 0.82 0.3 5.1 6.27 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 6.662857123783657 in pocket 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 13240 6217 231 V181E Thermonuclease Staphylococcus aureus 0.9 4.8 4.7 5.1 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 3.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 6.662857123783657 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13241 6217 231 V181E Thermonuclease Staphylococcus aureus 1.1 5.5 6.2 5.4 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 4.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 6.662857123783657 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13242 6217 231 V181E Thermonuclease Staphylococcus aureus 0.9 6.4 5.3 5.6 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 6.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 6.662857123783657 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13243 6217 231 V181E Thermonuclease Staphylococcus aureus 0.5 8.7 3.2 6.0 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 6.662857123783657 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13244 6217 231 V181E Thermonuclease Staphylococcus aureus 0.3 9.5 2.1 6.4 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 9.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 6.662857123783657 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13429 6297 231 V181A Thermonuclease Staphylococcus aureus 0.2 3.2 2.28 1.13 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 6.662857123783657 in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13430 6298 231 V181G Thermonuclease Staphylococcus aureus 5.0 0.48 1.18 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 6.662857123783657 in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13492 6337 231 V181S Thermonuclease Staphylococcus aureus 0.07 5.1 0.5 1.15 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 6.662857123783657 in pocket 7577991 10.1021/bi00042a029 1995 ProTherm SAAFEC_S1262.csv 13056 6143 231 N182G Thermonuclease Staphylococcus aureus 0.09 5.1 0.4 0.71 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 7.069999992847443 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13057 6144 231 N182A Thermonuclease Staphylococcus aureus 0.05 5.2 0.3 0.8 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 7.069999992847443 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13245 6218 231 N182E Thermonuclease Staphylococcus aureus 2.0 -0.1 9.5 4.7 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 3.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 7.069999992847443 20798341 10.1073/pnas.1004213107 2010 ProTherm 13246 6218 231 N182E Thermonuclease Staphylococcus aureus 2.1 1.2 10.6 5.0 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 7.069999992847443 20798341 10.1073/pnas.1004213107 2010 ProTherm 13247 6218 231 N182E Thermonuclease Staphylococcus aureus 1.9 2.4 9.3 5.0 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 6.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 7.069999992847443 20798341 10.1073/pnas.1004213107 2010 ProTherm 13248 6218 231 N182E Thermonuclease Staphylococcus aureus 1.4 4.4 7.4 5.2 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 8.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 7.069999992847443 20798341 10.1073/pnas.1004213107 2010 ProTherm 13249 6218 231 N182E Thermonuclease Staphylococcus aureus 1.3 4.5 7.1 5.6 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 9.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 7.069999992847443 20798341 10.1073/pnas.1004213107 2010 ProTherm 2454 1290 231 E183F Thermonuclease Staphylococcus aureus 62.0 -16.1 Unknown 37.6 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 13.36555544535319 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 2549 1290 231 E183F Thermonuclease Staphylococcus aureus 56.0 -13.3 Unknown 39.7 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 13.36555544535319 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 13360 1290 231 E183F Thermonuclease Staphylococcus aureus 0.47 3.1 2.4 0.78 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 13.36555544535319 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv 12842 5969 231 E183A Thermonuclease Staphylococcus aureus 0.68 1.9 3.7 0.77 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 13.36555544535319 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12843 5970 231 E183G Thermonuclease Staphylococcus aureus 0.53 3.1 2.5 0.87 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 13.36555544535319 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13012 6101 231 A184G Thermonuclease Staphylococcus aureus 0.59 1.3 4.2 1.03 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 8.769999885559082 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13013 6102 231 A184V Thermonuclease Staphylococcus aureus 0.54 1.9 3.6 0.98 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 8.769999885559082 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm SAAFEC_S1262.csv 13361 6254 231 A184F Thermonuclease Staphylococcus aureus 0.6 1.9 3.6 0.91 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 8.769999885559082 in pocket 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv 12769 5925 231 L185I Thermonuclease Staphylococcus aureus 0.65 1.1 4.3 6.68 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 9.292500138282776 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv 12770 5926 231 L185V Thermonuclease Staphylococcus aureus 0.5 2.0 3.4 6.82 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 9.292500138282776 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv 13147 6199 231 L185A Thermonuclease Staphylococcus aureus -4.6 1.0 yes Na2HPO4 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 9.292500138282776 2381904 10.1002/prot.340070402 1990 ProTherm 13417 6199 231 L185A Thermonuclease Staphylococcus aureus 0.1 4.6 0.88 0.96 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 9.292500138282776 2261461 10.1021/bi00487a007 1990 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13250 6219 231 L185E Thermonuclease Staphylococcus aureus 1.2 3.8 5.7 4.8 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 3.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 9.292500138282776 20798341 10.1073/pnas.1004213107 2010 ProTherm 13251 6219 231 L185E Thermonuclease Staphylococcus aureus 1.4 4.2 7.6 5.5 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 9.292500138282776 20798341 10.1073/pnas.1004213107 2010 ProTherm 13252 6219 231 L185E Thermonuclease Staphylococcus aureus 1.2 5.1 6.6 5.6 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 6.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 9.292500138282776 20798341 10.1073/pnas.1004213107 2010 ProTherm 13253 6219 231 L185E Thermonuclease Staphylococcus aureus 0.8 7.2 4.7 5.9 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 8.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 9.292500138282776 20798341 10.1073/pnas.1004213107 2010 ProTherm 13254 6219 231 L185E Thermonuclease Staphylococcus aureus 0.6 8.2 3.4 6.1 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 9.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 9.292500138282776 20798341 10.1073/pnas.1004213107 2010 ProTherm 2386 1223 231 V186T Thermonuclease Staphylococcus aureus 65.0 -10.3 Unknown 42.4 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 10.090000016348702 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 2481 1223 231 V186T Thermonuclease Staphylococcus aureus 65.0 -9.5 Unknown 43.5 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 10.090000016348702 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm Broom_S605.csv, EASE-MM_S1676.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S499.csv 13484 1223 231 V186T Thermonuclease Staphylococcus aureus 0.47 2.5 3.1 0.98 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 10.090000016348702 7577991 10.1021/bi00042a029 1995 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12738 5895 231 V186I Thermonuclease Staphylococcus aureus 0.87 -0.2 5.6 6.41 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 10.090000016348702 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 12739 5896 231 V186L Thermonuclease Staphylococcus aureus 0.71 0.8 4.6 6.48 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 10.090000016348702 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv 13255 6220 231 V186E Thermonuclease Staphylococcus aureus 1.5 2.0 7.5 5.0 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 3.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 10.090000016348702 20798341 10.1073/pnas.1004213107 2010 ProTherm 13256 6220 231 V186E Thermonuclease Staphylococcus aureus 1.7 2.8 8.9 5.3 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 4.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 10.090000016348702 20798341 10.1073/pnas.1004213107 2010 ProTherm 13257 6220 231 V186E Thermonuclease Staphylococcus aureus 1.6 3.2 8.5 5.3 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 10.090000016348702 20798341 10.1073/pnas.1004213107 2010 ProTherm 13258 6220 231 V186E Thermonuclease Staphylococcus aureus 1.4 4.1 7.6 5.3 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 6.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 10.090000016348702 20798341 10.1073/pnas.1004213107 2010 ProTherm 13259 6220 231 V186E Thermonuclease Staphylococcus aureus 1.0 6.5 5.4 5.7 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 8.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 10.090000016348702 20798341 10.1073/pnas.1004213107 2010 ProTherm 13260 6220 231 V186E Thermonuclease Staphylococcus aureus 0.7 7.4 4.2 5.9 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 9.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 10.090000016348702 20798341 10.1073/pnas.1004213107 2010 ProTherm 13431 6299 231 V186A Thermonuclease Staphylococcus aureus 0.4 2.9 2.58 0.93 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 10.090000016348702 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13493 6338 231 V186S Thermonuclease Staphylococcus aureus 0.11 4.9 0.7 0.87 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 10.090000016348702 7577991 10.1021/bi00042a029 1995 ProTherm SAAFEC_S1262.csv 4259 2166 231 R187C Thermonuclease Staphylococcus aureus -11.1 yes 41.9 Sodium phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 11.230909044092352 8580845 10.1002/pro.5560041211 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 13608 2166 231 R187C Thermonuclease Staphylococcus aureus 0.47 2.7 2.8 5.96 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 11.230909044092352 8580845 10.1002/pro.5560041211 1995 ProTherm SAAFEC_S1262.csv 4267 2172 231 R187F Thermonuclease Staphylococcus aureus -15.1 yes 37.9 Sodium phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 11.230909044092352 8580845 10.1002/pro.5560041211 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 13362 2172 231 R187F Thermonuclease Staphylococcus aureus 0.44 3.1 2.4 0.84 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 11.230909044092352 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv 13616 2172 231 R187F Thermonuclease Staphylococcus aureus 0.44 3.1 2.4 5.51 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 11.230909044092352 8580845 10.1002/pro.5560041211 1995 ProTherm SAAFEC_S1262.csv 12912 6037 231 R187A Thermonuclease Staphylococcus aureus 0.62 1.4 4.2 0.97 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 11.230909044092352 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12913 6038 231 R187G Thermonuclease Staphylococcus aureus 0.45 2.4 3.2 1.01 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 11.230909044092352 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13068 6155 231 Q188G Thermonuclease Staphylococcus aureus 0.58 1.5 4.0 1.01 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 17.11777771843804 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13069 6156 231 Q188A Thermonuclease Staphylococcus aureus 0.86 -0.1 5.6 0.95 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 17.11777771843804 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 13052 6139 231 G189A Thermonuclease Staphylococcus aureus 0.16 4.5 1.0 0.93 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 12.437500238418579 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm SAAFEC_S1262.csv 13560 6139 231 G189A Thermonuclease Staphylococcus aureus 0.16 4.4 1.0 0.93 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 12.437500238418579 in pocket 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm SAAFEC_S1262.csv 13053 6140 231 G189V Thermonuclease Staphylococcus aureus 7.5 < -2.0 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 12.437500238418579 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm 12771 5927 231 L190I Thermonuclease Staphylococcus aureus 0.32 3.4 2.0 6.02 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.555000066757202 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv 12772 5928 231 L190V Thermonuclease Staphylococcus aureus 0.25 3.9 1.5 6.31 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12.555000066757202 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv 13014 6103 231 A191G Thermonuclease Staphylococcus aureus 0.66 1.0 4.5 0.99 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 11.890000152587891 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13015 6104 231 A191V Thermonuclease Staphylococcus aureus 0.43 3.1 2.4 0.81 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 11.890000152587891 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm SAAFEC_S1262.csv 13261 6221 231 A191E Thermonuclease Staphylococcus aureus 1.1 4.4 5.1 4.5 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 3.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 11.890000152587891 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13262 6221 231 A191E Thermonuclease Staphylococcus aureus 1.3 5.0 6.8 5.2 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 11.890000152587891 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13263 6221 231 A191E Thermonuclease Staphylococcus aureus 1.1 5.5 6.2 5.4 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 6.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 11.890000152587891 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13264 6221 231 A191E Thermonuclease Staphylococcus aureus 0.8 7.7 4.2 5.4 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 11.890000152587891 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13265 6221 231 A191E Thermonuclease Staphylococcus aureus 0.7 8.1 3.4 5.1 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 9.1 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 11.890000152587891 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 12886 6012 231 K192A Thermonuclease Staphylococcus aureus 0.66 1.3 4.3 0.93 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 30.556666480170357 in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12887 6013 231 K192G Thermonuclease Staphylococcus aureus 0.44 2.7 2.9 0.91 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 30.556666480170357 in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 2387 1224 231 V193T Thermonuclease Staphylococcus aureus 59.0 -10.1 Unknown 42.6 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 14.809999738420759 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 2482 1224 231 V193T Thermonuclease Staphylococcus aureus 55.0 -10.2 Unknown 42.8 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 14.809999738420759 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm Broom_S605.csv, EASE-MM_S1676.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S499.csv 13485 1224 231 V193T Thermonuclease Staphylococcus aureus 0.47 2.3 3.3 1.05 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 14.809999738420759 in pocket 7577991 10.1021/bi00042a029 1995 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12740 5897 231 V193I Thermonuclease Staphylococcus aureus 0.7 0.7 4.7 6.74 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 14.809999738420759 in pocket 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv 12741 5898 231 V193L Thermonuclease Staphylococcus aureus 0.69 0.9 4.5 6.61 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 14.809999738420759 in pocket 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv 13432 6300 231 V193A Thermonuclease Staphylococcus aureus 0.1 4.7 0.78 0.64 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 14.809999738420759 in pocket 2261461 10.1021/bi00487a007 1990 ProTherm 13534 6300 231 V193A Thermonuclease Staphylococcus aureus 0.24 4.2 1.4 0.84 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 14.809999738420759 in pocket 7577991 10.1021/bi00042a029 1995 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv 13433 6301 231 V193G Thermonuclease Staphylococcus aureus 0.1 4.9 0.58 0.75 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 14.809999738420759 in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13494 6339 231 V193S Thermonuclease Staphylococcus aureus 0.14 4.8 0.8 0.83 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 14.809999738420759 in pocket 7577991 10.1021/bi00042a029 1995 ProTherm SAAFEC_S1262.csv 2455 1291 231 A194F Thermonuclease Staphylococcus aureus 73.0 -6.9 Unknown 45.8 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 16.879999923706055 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv 2550 1291 231 A194F Thermonuclease Staphylococcus aureus 65.0 -6.6 Unknown 46.4 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 16.879999923706055 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4268 1291 231 A194F Thermonuclease Staphylococcus aureus -6.6 yes 46.4 Sodium phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 16.879999923706055 in tunnel in pocket 8580845 10.1002/pro.5560041211 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 13363 1291 231 A194F Thermonuclease Staphylococcus aureus 0.64 1.6 3.9 0.93 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 16.879999923706055 in tunnel in pocket 9578580 10.1021/bi9725069 1998 ProTherm 13617 1291 231 A194F Thermonuclease Staphylococcus aureus 0.65 1.3 4.2 6.49 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 16.879999923706055 in tunnel in pocket 8580845 10.1002/pro.5560041211 1995 ProTherm SAAFEC_S983.csv 4260 2167 231 A194C Thermonuclease Staphylococcus aureus -2.8 yes 50.2 Sodium phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 16.879999923706055 in tunnel in pocket 8580845 10.1002/pro.5560041211 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 13609 2167 231 A194C Thermonuclease Staphylococcus aureus 0.73 0.8 4.7 6.53 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 16.879999923706055 in tunnel in pocket 8580845 10.1002/pro.5560041211 1995 ProTherm SAAFEC_S1262.csv 13016 6105 231 A194G Thermonuclease Staphylococcus aureus 0.86 0.0 5.5 0.93 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 16.879999923706055 in tunnel in pocket 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 13017 6106 231 A194V Thermonuclease Staphylococcus aureus 0.67 1.5 4.0 0.88 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 16.879999923706055 in tunnel in pocket 1610820 10.1021/bi00140a005 1992 ProTherm SAAFEC_S1262.csv 2398 1235 231 Y195F Thermonuclease Staphylococcus aureus 96.0 -0.4 Unknown 52.3 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 33.795000076293945 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, guerios_625_map.csv, PoPMuSiC-2.0_S2648.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 2493 1235 231 Y195F Thermonuclease Staphylococcus aureus 92.0 0.9 Unknown 53.9 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 33.795000076293945 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv 13364 1235 231 Y195F Thermonuclease Staphylococcus aureus 0.84 0.0 5.5 0.98 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 33.795000076293945 in tunnel in pocket 9578580 10.1021/bi9725069 1998 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 13501 1235 231 Y195F Thermonuclease Staphylococcus aureus 0.86 0.0 5.6 0.98 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 33.795000076293945 in tunnel in pocket 7577991 10.1021/bi00042a029 1995 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 2403 1240 231 Y195L Thermonuclease Staphylococcus aureus 89.0 -0.7 Unknown 52.0 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 33.795000076293945 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 2498 1240 231 Y195L Thermonuclease Staphylococcus aureus 86.0 0.5 Unknown 53.5 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 33.795000076293945 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 13508 1240 231 Y195L Thermonuclease Staphylococcus aureus 0.86 -0.2 5.8 1.0 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 33.795000076293945 in tunnel in pocket 7577991 10.1021/bi00042a029 1995 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 13463 6327 231 Y195A Thermonuclease Staphylococcus aureus 0.8 0.0 5.48 0.99 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 33.795000076293945 in tunnel in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 13548 6327 231 Y195A Thermonuclease Staphylococcus aureus 0.81 -0.1 5.5 0.99 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 33.795000076293945 in tunnel in pocket 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 13464 6328 231 Y195G Thermonuclease Staphylococcus aureus 0.7 0.3 5.18 0.97 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 33.795000076293945 in tunnel in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 13549 6328 231 Y195G Thermonuclease Staphylococcus aureus 0.78 0.2 5.2 0.97 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 33.795000076293945 in tunnel in pocket 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 2388 1225 231 V196T Thermonuclease Staphylococcus aureus 86.0 -1.0 Unknown 51.7 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 25.717143195016043 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S499.csv 2483 1225 231 V196T Thermonuclease Staphylococcus aureus 83.0 0.3 Unknown 53.3 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 25.717143195016043 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 13486 1225 231 V196T Thermonuclease Staphylococcus aureus 0.78 0.3 5.3 1.02 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 25.717143195016043 in tunnel in pocket 7577991 10.1021/bi00042a029 1995 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 2392 1229 231 V196S Thermonuclease Staphylococcus aureus 84.0 -0.5 Unknown 52.2 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 25.717143195016043 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, EASE-MM_S1676.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv 2487 1229 231 V196S Thermonuclease Staphylococcus aureus 89.0 0.6 Unknown 53.6 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 25.717143195016043 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1925.csv, AUTOMUTE_S1962.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, PoPMuSiC-2.0_S2648.csv, Broom_S605.csv 13495 1229 231 V196S Thermonuclease Staphylococcus aureus 0.82 0.0 5.6 1.02 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 25.717143195016043 in tunnel in pocket 7577991 10.1021/bi00042a029 1995 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 12742 5899 231 V196I Thermonuclease Staphylococcus aureus 0.79 0.1 5.3 6.68 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 25.717143195016043 in tunnel in pocket 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 12743 5900 231 V196L Thermonuclease Staphylococcus aureus 0.66 1.1 4.3 6.48 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 25.717143195016043 in tunnel in pocket 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv 13434 6302 231 V196A Thermonuclease Staphylococcus aureus 0.8 0.0 5.48 0.96 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 25.717143195016043 in tunnel in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 13435 6303 231 V196G Thermonuclease Staphylococcus aureus 0.8 0.2 5.28 0.94 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 25.717143195016043 in tunnel in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 2399 1236 231 Y197F Thermonuclease Staphylococcus aureus 86.0 -0.5 Unknown 52.2 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 40.35249948501587 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 2494 1236 231 Y197F Thermonuclease Staphylococcus aureus 82.0 0.8 Unknown 53.8 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 40.35249948501587 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm Broom_S605.csv 13365 1236 231 Y197F Thermonuclease Staphylococcus aureus 0.83 0.1 5.4 0.97 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 40.35249948501587 in tunnel in pocket 9578580 10.1021/bi9725069 1998 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 13502 1236 231 Y197F Thermonuclease Staphylococcus aureus 0.85 0.1 5.5 0.96 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 40.35249948501587 in tunnel in pocket 7577991 10.1021/bi00042a029 1995 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 2404 1241 231 Y197L Thermonuclease Staphylococcus aureus 91.0 -1.4 Unknown 51.3 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 40.35249948501587 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm HotMuSiC_S1626.csv, AUTOMUTE_S1962.csv, Broom_S605.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 2499 1241 231 Y197L Thermonuclease Staphylococcus aureus 85.0 0.2 Unknown 53.2 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 40.35249948501587 in tunnel in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 13509 1241 231 Y197L Thermonuclease Staphylococcus aureus 0.81 0.3 5.3 0.97 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 40.35249948501587 in tunnel in pocket 7577991 10.1021/bi00042a029 1995 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 13465 6329 231 Y197A Thermonuclease Staphylococcus aureus 0.7 0.3 5.18 0.99 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 40.35249948501587 in tunnel in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 13466 6330 231 Y197G Thermonuclease Staphylococcus aureus 0.7 0.7 4.78 0.96 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 40.35249948501587 in tunnel in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 2456 1292 231 K198F Thermonuclease Staphylococcus aureus 89.0 0.2 Unknown 52.9 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 37.91111161973741 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, HotMuSiC_S1626.csv, Saraboji_S2204.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv 2551 1292 231 K198F Thermonuclease Staphylococcus aureus 82.0 0.6 Unknown 53.6 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 37.91111161973741 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 13366 1292 231 K198F Thermonuclease Staphylococcus aureus 0.91 0.1 5.4 0.91 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 37.91111161973741 in pocket 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 3424 1781 231 K198G Thermonuclease Staphylococcus aureus 86.9 3.8 yes 54.4 Tris-HCl 0.01 M NaCl 0.1 M Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 37.91111161973741 in pocket 1991099 10.1021/bi00219a005 1991 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 12889 1781 231 K198G Thermonuclease Staphylococcus aureus 0.96 -1.0 6.6 0.99 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 37.91111161973741 in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12888 6014 231 K198A Thermonuclease Staphylococcus aureus 0.9 -0.7 6.3 1.01 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 37.91111161973741 in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 3421 1779 231 P199G Thermonuclease Staphylococcus aureus 91.9 5.0 yes 55.6 Tris-HCl 0.01 M NaCl 0.1 M Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 22.304285866873606 in pocket 1991099 10.1021/bi00219a005 1991 ProTherm AUTOMUTE_S1962.csv, Broom_S605.csv, Saraboji_S2204.csv, PoPMuSiC-2.0_S2648.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv, STRUM_Q3421.csv 13034 1779 231 P199G Thermonuclease Staphylococcus aureus 1.0 -0.9 6.4 0.94 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 22.304285866873606 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv 14397 1779 231 P199G Thermonuclease Staphylococcus aureus 0.4 -1.6 6.2 13.6 yes cacodylate 10 mM 0.0 Fluorescence GdnSCN 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 22.304285866873606 in pocket 8448112 10.1021/bi00061a010 1993 ProTherm 3422 1780 231 P199T Thermonuclease Staphylococcus aureus 71.7 0.6 yes 51.2 Tris-HCl 0.01 M NaCl 0.1 M Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 22.304285866873606 in pocket 1991099 10.1021/bi00219a005 1991 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Broom_S605.csv, Saraboji_S1791.csv 14398 1780 231 P199T Thermonuclease Staphylococcus aureus 0.4 -1.1 5.7 14.6 yes cacodylate 10 mM 0.0 Fluorescence GdnSCN 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 22.304285866873606 in pocket 8448112 10.1021/bi00061a010 1993 ProTherm SAAFEC_S1262.csv 13035 6123 231 P199A Thermonuclease Staphylococcus aureus 0.99 -0.8 6.3 0.94 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 22.304285866873606 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13299 6241 231 P199L Thermonuclease Staphylococcus aureus -0.2 0.92 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 22.304285866873606 in pocket 8399139 10.1021/bi00089a032 1993 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 13367 6255 231 P199F Thermonuclease Staphylococcus aureus 0.96 -0.3 5.8 0.92 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 22.304285866873606 in pocket 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 15500 7195 231 H206L, P199G Thermonuclease Staphylococcus aureus 0.75 3.2 5.9 yes Bis-Tris 10 mM 21.0 Fluorescence GdnHCl 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 4.0 1STN 22.304285866873606, 25.575000286102295 in pocket 8620010 10.1021/bi952012g 1996 ProTherm 15544 7234 231 P199L, N200D Thermonuclease Staphylococcus aureus 1.0 0.86 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0, 8.0 1STN 22.304285866873606, 15.703750133514404 in tunnel in pocket 8399139 10.1021/bi00089a032 1993 ProTherm 13058 6145 231 N200G Thermonuclease Staphylococcus aureus 0.6 1.9 3.6 0.88 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 15.703750133514404 in tunnel in pocket 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13567 6145 231 N200G Thermonuclease Staphylococcus aureus 0.6 1.8 3.6 0.88 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 15.703750133514404 in tunnel in pocket 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm SAAFEC_S1262.csv 13059 6146 231 N200A Thermonuclease Staphylococcus aureus 0.55 2.1 3.4 0.92 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 15.703750133514404 in tunnel in pocket 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13566 6146 231 N200A Thermonuclease Staphylococcus aureus 0.55 2.0 3.4 0.92 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 15.703750133514404 in tunnel in pocket 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm SAAFEC_S1262.csv 13148 6200 231 N200D Thermonuclease Staphylococcus aureus -2.5 0.89 yes Na2HPO4 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 15.703750133514404 in tunnel in pocket 2381904 10.1002/prot.340070402 1990 ProTherm 13300 6200 231 N200D Thermonuclease Staphylococcus aureus 2.4 0.86 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 15.703750133514404 in tunnel in pocket 8399139 10.1021/bi00089a032 1993 ProTherm capriotti_S1615_map.csv, capriotti_S388_map.csv, guerios_625_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13266 6222 231 N200E Thermonuclease Staphylococcus aureus 2.0 1.9 9.9 4.9 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 15.703750133514404 in tunnel in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm SAAFEC_S1262.csv 13267 6222 231 N200E Thermonuclease Staphylococcus aureus 2.0 1.9 9.7 4.9 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 9.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 15.703750133514404 in tunnel in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm SAAFEC_S1262.csv 13060 6147 231 N201G Thermonuclease Staphylococcus aureus 0.7 1.3 4.2 0.88 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 23.552500247955322 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13569 6147 231 N201G Thermonuclease Staphylococcus aureus 0.7 1.2 4.2 0.88 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 23.552500247955322 in pocket 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm SAAFEC_S1262.csv 13061 6148 231 N201A Thermonuclease Staphylococcus aureus 0.68 1.3 4.2 0.91 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 23.552500247955322 in pocket 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13568 6148 231 N201A Thermonuclease Staphylococcus aureus 0.68 1.2 4.2 0.91 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 23.552500247955322 in pocket 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm SAAFEC_S1262.csv 2415 1251 231 T202S Thermonuclease Staphylococcus aureus 78.0 -2.8 Unknown 49.9 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 17.55142879486084 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1925.csv, HotMuSiC_S1626.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 2510 1251 231 T202S Thermonuclease Staphylococcus aureus 81.0 -1.2 Unknown 51.8 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 17.55142879486084 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm STRUM_Q306.csv, STRUM_Q3421.csv 13517 1251 231 T202S Thermonuclease Staphylococcus aureus 0.75 0.6 5.0 0.99 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 17.55142879486084 7577991 10.1021/bi00042a029 1995 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 2423 1259 231 T202V Thermonuclease Staphylococcus aureus 73.0 -5.4 Unknown 47.3 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 17.55142879486084 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, AUTOMUTE_S1962.csv, Saraboji_S2204.csv 2518 1259 231 T202V Thermonuclease Staphylococcus aureus 65.0 -4.8 Unknown 48.2 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 17.55142879486084 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm STRUM_Q3421.csv 13525 1259 231 T202V Thermonuclease Staphylococcus aureus 0.61 1.8 3.8 0.93 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 17.55142879486084 7577991 10.1021/bi00042a029 1995 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 2431 1267 231 T202C Thermonuclease Staphylococcus aureus 66.0 -5.3 Unknown 47.4 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 17.55142879486084 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm HotMuSiC_S1626.csv 2526 1267 231 T202C Thermonuclease Staphylococcus aureus 70.0 -5.6 Unknown 47.4 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 17.55142879486084 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv 13533 1267 231 T202C Thermonuclease Staphylococcus aureus 0.61 1.7 3.9 0.94 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 17.55142879486084 7577991 10.1021/bi00042a029 1995 ProTherm SAAFEC_S1262.csv 2438 1274 231 T202I Thermonuclease Staphylococcus aureus 64.0 -5.0 Unknown 47.7 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 17.55142879486084 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, EASE-MM_S543.csv, PoPMuSiC-2.0_S2648.csv 2533 1274 231 T202I Thermonuclease Staphylococcus aureus 64.0 -4.6 Unknown 48.4 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 17.55142879486084 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm Broom_S605.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv 12784 1274 231 T202I Thermonuclease Staphylococcus aureus 0.61 1.7 3.7 5.99 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 17.55142879486084 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv 13097 6179 231 T202G Thermonuclease Staphylococcus aureus 0.56 2.1 3.4 0.9 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 17.55142879486084 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13098 6180 231 T202A Thermonuclease Staphylococcus aureus 0.66 1.2 4.3 0.94 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 17.55142879486084 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12902 6027 231 H203A Thermonuclease Staphylococcus aureus 0.4 3.1 2.5 0.87 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 15.113000011444091 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12903 6028 231 H203G Thermonuclease Staphylococcus aureus 0.22 4.2 1.4 0.83 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 15.113000011444091 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 2457 1293 231 E204F Thermonuclease Staphylococcus aureus 91.0 -1.0 Unknown 51.7 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 21.238888634575737 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, HotMuSiC_S1626.csv, Saraboji_S2204.csv 2552 1293 231 E204F Thermonuclease Staphylococcus aureus 80.0 -0.2 Unknown 52.8 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 21.238888634575737 in pocket 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 13368 1293 231 E204F Thermonuclease Staphylococcus aureus 0.82 0.8 4.7 0.86 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 21.238888634575737 in pocket 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv 12844 5971 231 E204A Thermonuclease Staphylococcus aureus 0.78 0.4 5.2 0.97 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 21.238888634575737 in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 12845 5972 231 E204G Thermonuclease Staphylococcus aureus 0.54 2.2 3.4 0.89 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 21.238888634575737 in pocket 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12947 6070 231 E204K Thermonuclease Staphylococcus aureus 0.46 2.7 2.7 5.87 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 21.238888634575737 in pocket 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv 12948 6071 231 E204Q Thermonuclease Staphylococcus aureus 0.6 1.6 3.8 6.2 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 21.238888634575737 in pocket 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv 2458 1294 231 Q205F Thermonuclease Staphylococcus aureus 85.0 -2.0 Unknown 50.7 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 33.98555586073134 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, EASE-MM_S543.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, HotMuSiC_S1626.csv 2553 1294 231 Q205F Thermonuclease Staphylococcus aureus 86.0 -0.5 Unknown 52.5 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 33.98555586073134 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 13369 1294 231 Q205F Thermonuclease Staphylococcus aureus 0.78 0.7 4.8 0.94 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 33.98555586073134 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv 13070 6157 231 Q205G Thermonuclease Staphylococcus aureus 0.76 0.6 4.9 0.95 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 33.98555586073134 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 13071 6158 231 Q205A Thermonuclease Staphylococcus aureus 0.83 0.4 5.1 0.9 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 33.98555586073134 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 218 112 231 H206L Thermonuclease Staphylococcus aureus 2.0 81.0 5.1 yes 56.5 phosphate 0.05 M NaCl 0.1 M DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 25.575000286102295 8518730 10.1002/pro.5560020408 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 224 112 231 H206L Thermonuclease Staphylococcus aureus 2.0 56.0 8.3 yes 55.3 phosphate 0.05 M NaCl 0.1 M DSC Thermal 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 25.575000286102295 8518730 10.1002/pro.5560020408 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3423 112 231 H206L Thermonuclease Staphylococcus aureus 92.0 5.8 yes 56.4 Tris-HCl 0.01 M NaCl 0.1 M Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 25.575000286102295 1991099 10.1021/bi00219a005 1991 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q306.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3445 112 231 H206L Thermonuclease Staphylococcus aureus 86.1 8.4 yes 56.2 Unknown NaCl 0.3 M NMR Thermal 5.2 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 25.575000286102295 2372535 10.1021/bi00471a003 1990 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, Broom_S605.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3547 112 231 H206L Thermonuclease Staphylococcus aureus yes 56.0 Bis-Tris 10 mM NMR Thermal 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 25.575000286102295 8756688 10.1021/bi960309o 1996 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 3548 112 231 H206L Thermonuclease Staphylococcus aureus yes 58.0 Bis-Tris 10 mM NMR Thermal 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 25.575000286102295 8756688 10.1021/bi960309o 1996 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 3549 112 231 H206L Thermonuclease Staphylococcus aureus yes 51.2 Bis-Tris 10 mM NMR Thermal 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 25.575000286102295 8756688 10.1021/bi960309o 1996 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 3550 112 231 H206L Thermonuclease Staphylococcus aureus yes 64.4 Bis-Tris 10 mM NMR Thermal 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 25.575000286102295 8756688 10.1021/bi960309o 1996 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 3551 112 231 H206L Thermonuclease Staphylococcus aureus yes 49.0 Bis-Tris 10 mM NMR Thermal 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 25.575000286102295 8756688 10.1021/bi960309o 1996 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 3552 112 231 H206L Thermonuclease Staphylococcus aureus yes 54.0 Bis-Tris 10 mM NMR Thermal 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 25.575000286102295 8756688 10.1021/bi960309o 1996 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 3553 112 231 H206L Thermonuclease Staphylococcus aureus yes 30.0 Bis-Tris 10 mM NMR Thermal 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 25.575000286102295 8756688 10.1021/bi960309o 1996 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, Broom_S605.csv 7608 112 231 H206L Thermonuclease Staphylococcus aureus 2.0 -1.3 yes phosphate 0.05 M 51.4 NaCl 0.1 M DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 25.575000286102295 8518730 10.1002/pro.5560020408 1993 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 7795 112 231 H206L Thermonuclease Staphylococcus aureus 2.0 -1.9 yes phosphate 0.05 M 47.0 NaCl 0.1 M DSC Thermal 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 25.575000286102295 8518730 10.1002/pro.5560020408 1993 ProTherm capriotti_S1615_map.csv 8084 112 231 H206L Thermonuclease Staphylococcus aureus 4.39 90.3 yes Bis-Tris 10 mM 40.0 NMR Thermal 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 25.575000286102295 8756688 10.1021/bi960309o 1996 ProTherm 8085 112 231 H206L Thermonuclease Staphylococcus aureus 3.0 55.2 yes Bis-Tris 10 mM 40.0 NMR Thermal 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 25.575000286102295 8756688 10.1021/bi960309o 1996 ProTherm 8086 112 231 H206L Thermonuclease Staphylococcus aureus 1.83 52.8 yes Bis-Tris 10 mM 40.0 NMR Thermal 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 25.575000286102295 8756688 10.1021/bi960309o 1996 ProTherm 8087 112 231 H206L Thermonuclease Staphylococcus aureus 5.85 80.9 yes Bis-Tris 10 mM 40.0 NMR Thermal 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 25.575000286102295 8756688 10.1021/bi960309o 1996 ProTherm 8088 112 231 H206L Thermonuclease Staphylococcus aureus 1.92 69.0 yes Bis-Tris 10 mM 40.0 NMR Thermal 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 25.575000286102295 8756688 10.1021/bi960309o 1996 ProTherm 8089 112 231 H206L Thermonuclease Staphylococcus aureus 1.98 46.3 yes Bis-Tris 10 mM 40.0 NMR Thermal 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 25.575000286102295 8756688 10.1021/bi960309o 1996 ProTherm 8093 112 231 H206L Thermonuclease Staphylococcus aureus 0.0 -0.7 2.1 1.0 yes Unknown 40.0 NaCl 0.3 M NMR Thermal 5.2 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 25.575000286102295 2372535 10.1021/bi00471a003 1990 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 12662 112 231 H206L Thermonuclease Staphylococcus aureus 1.05 5.98 10.65 yes Bis-Tris 10 mM 21.5 Fluorescence GdnHCl 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 25.575000286102295 8756688 10.1021/bi960309o 1996 ProTherm 12663 112 231 H206L Thermonuclease Staphylococcus aureus 1.05 4.98 8.08 yes Bis-Tris 10 mM 21.5 Fluorescence GdnHCl 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 25.575000286102295 8756688 10.1021/bi960309o 1996 ProTherm 12664 112 231 H206L Thermonuclease Staphylococcus aureus 1.06 5.39 8.65 yes Bis-Tris 10 mM 21.5 Fluorescence GdnHCl 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 25.575000286102295 8756688 10.1021/bi960309o 1996 ProTherm 12665 112 231 H206L Thermonuclease Staphylococcus aureus 1.08 5.55 8.76 yes Bis-Tris 10 mM 21.5 Fluorescence GdnHCl 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 25.575000286102295 8756688 10.1021/bi960309o 1996 ProTherm 12666 112 231 H206L Thermonuclease Staphylococcus aureus 0.6 3.27 9.31 yes Bis-Tris 10 mM 21.5 Fluorescence GdnHCl 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 25.575000286102295 8756688 10.1021/bi960309o 1996 ProTherm 12667 112 231 H206L Thermonuclease Staphylococcus aureus 1.23 5.95 8.25 yes Bis-Tris 10 mM 21.5 Fluorescence GdnHCl 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 25.575000286102295 8756688 10.1021/bi960309o 1996 ProTherm 12668 112 231 H206L Thermonuclease Staphylococcus aureus 0.52 2.76 9.04 yes Bis-Tris 10 mM 21.5 Fluorescence GdnHCl 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 25.575000286102295 8756688 10.1021/bi960309o 1996 ProTherm 12701 112 231 H206L Thermonuclease Staphylococcus aureus 0.75 1.9 5.8 yes Bis-Tris 10 mM 21.0 Fluorescence GdnHCl 5.5 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 25.575000286102295 8620010 10.1021/bi952012g 1996 ProTherm 12904 6029 231 H206A Thermonuclease Staphylococcus aureus 0.91 -0.4 6.0 0.96 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 25.575000286102295 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 12905 6030 231 H206G Thermonuclease Staphylococcus aureus 0.72 0.5 5.1 1.02 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 25.575000286102295 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 12949 6072 231 H206E Thermonuclease Staphylococcus aureus 0.93 -0.2 5.6 6.07 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 25.575000286102295 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 12950 6073 231 H206Q Thermonuclease Staphylococcus aureus 0.94 -0.6 6.0 6.4 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 25.575000286102295 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 13370 6256 231 H206F Thermonuclease Staphylococcus aureus 0.94 -0.3 5.8 0.93 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 25.575000286102295 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 12773 5929 231 L207I Thermonuclease Staphylococcus aureus 0.68 1.0 4.4 6.54 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 16.62999999523163 in pocket 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv 12774 5930 231 L207V Thermonuclease Staphylococcus aureus 0.47 2.3 3.1 6.57 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 16.62999999523163 in pocket 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv 13268 6223 231 L207E Thermonuclease Staphylococcus aureus 1.2 4.0 5.5 4.8 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 3.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 16.62999999523163 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13269 6223 231 L207E Thermonuclease Staphylococcus aureus 1.4 4.6 7.2 5.3 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 16.62999999523163 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13270 6223 231 L207E Thermonuclease Staphylococcus aureus 1.1 5.8 5.9 5.4 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 6.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 16.62999999523163 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13271 6223 231 L207E Thermonuclease Staphylococcus aureus 0.7 8.2 3.7 5.3 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 16.62999999523163 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13272 6223 231 L207E Thermonuclease Staphylococcus aureus 0.5 9.1 2.5 5.2 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 9.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 16.62999999523163 in pocket 20798341 10.1073/pnas.1004213107 2010 ProTherm 13418 6290 231 L207A Thermonuclease Staphylococcus aureus 0.1 4.9 0.38 0.66 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 16.62999999523163 in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12914 6039 231 R208A Thermonuclease Staphylococcus aureus 0.57 1.7 3.9 0.98 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 20.95727287639271 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12915 6040 231 R208G Thermonuclease Staphylococcus aureus 0.39 2.9 2.7 0.94 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 20.95727287639271 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 2459 1295 231 K209F Thermonuclease Staphylococcus aureus 86.0 -1.2 Unknown 51.5 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 28.32555601331923 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv 2554 1295 231 K209F Thermonuclease Staphylococcus aureus 89.0 -0.6 Unknown 52.4 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 28.32555601331923 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, AUTOMUTE_S1962.csv 13371 1295 231 K209F Thermonuclease Staphylococcus aureus 0.81 0.3 5.2 0.97 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 28.32555601331923 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 12890 6015 231 K209A Thermonuclease Staphylococcus aureus 0.84 -0.2 5.8 1.02 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 28.32555601331923 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 12891 6016 231 K209G Thermonuclease Staphylococcus aureus 0.67 0.7 4.9 1.05 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 28.32555601331923 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12951 6074 231 K209E Thermonuclease Staphylococcus aureus 0.86 0.0 5.4 6.34 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 28.32555601331923 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 12952 6075 231 K209Q Thermonuclease Staphylococcus aureus 0.84 0.0 5.4 6.4 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 28.32555601331923 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 2405 1242 231 S210A Thermonuclease Staphylococcus aureus 94.0 3.0 Unknown 55.7 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 13.889999866485596 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm HotMuSiC_S1626.csv 2500 1242 231 S210A Thermonuclease Staphylococcus aureus 97.0 4.9 Unknown 57.9 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 13.889999866485596 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 4339 1242 231 S210A Thermonuclease Staphylococcus aureus Unknown 57.3 Sodium phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 13.889999866485596 11023780 10.1006/jmbi.2000.4140 2000 ProTherm 13078 1242 231 S210A Thermonuclease Staphylococcus aureus 0.96 -0.7 6.2 0.96 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 13.889999866485596 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13624 1242 231 S210A Thermonuclease Staphylococcus aureus 6.1 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 13.889999866485596 11023780 10.1006/jmbi.2000.4140 2000 ProTherm 2460 1296 231 S210F Thermonuclease Staphylococcus aureus 81.0 -3.8 Unknown 48.9 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 13.889999866485596 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, Broom_S605.csv 2555 1296 231 S210F Thermonuclease Staphylococcus aureus 76.0 -3.3 Unknown 49.7 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 13.889999866485596 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 13372 1296 231 S210F Thermonuclease Staphylococcus aureus 0.68 1.0 4.5 1.0 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 13.889999866485596 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv 13077 6163 231 S210G Thermonuclease Staphylococcus aureus 0.59 1.6 3.9 0.99 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 13.889999866485596 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12846 5973 231 E211A Thermonuclease Staphylococcus aureus 0.51 2.4 3.2 0.86 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 15.43444432152642 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12847 5974 231 E211G Thermonuclease Staphylococcus aureus 0.27 3.8 1.8 0.85 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 15.43444432152642 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13373 6257 231 E211F Thermonuclease Staphylococcus aureus 0.26 4.0 1.5 0.89 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 15.43444432152642 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv 13018 6107 231 A212G Thermonuclease Staphylococcus aureus 0.67 1.1 4.4 0.96 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 13.848000144958496 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13019 6108 231 A212V Thermonuclease Staphylococcus aureus 0.66 1.2 4.3 0.96 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 13.848000144958496 1610820 10.1021/bi00140a005 1992 ProTherm SAAFEC_S1262.csv 13072 6159 231 Q213G Thermonuclease Staphylococcus aureus 0.49 2.4 3.1 0.92 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 19.462221993340385 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13073 6160 231 Q213A Thermonuclease Staphylococcus aureus 0.8 0.2 5.3 0.98 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 19.462221993340385 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 13374 6258 231 Q213F Thermonuclease Staphylococcus aureus 0.77 0.7 4.8 0.95 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 19.462221993340385 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv 13020 6109 231 A214G Thermonuclease Staphylococcus aureus 0.29 3.7 1.8 0.89 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 15.605999946594238 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13021 6110 231 A214V Thermonuclease Staphylococcus aureus 0.12 4.8 0.7 0.86 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 15.605999946594238 1610820 10.1021/bi00140a005 1992 ProTherm SAAFEC_S1262.csv 13273 6224 231 A214E Thermonuclease Staphylococcus aureus 1.2 5.8 6.0 5.2 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 4.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 15.605999946594238 20798341 10.1073/pnas.1004213107 2010 ProTherm 13274 6224 231 A214E Thermonuclease Staphylococcus aureus 0.9 6.8 4.9 5.2 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 6.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 15.605999946594238 20798341 10.1073/pnas.1004213107 2010 ProTherm 13275 6224 231 A214E Thermonuclease Staphylococcus aureus 0.9 8.2 3.7 4.4 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.9 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 15.605999946594238 20798341 10.1073/pnas.1004213107 2010 ProTherm 13276 6224 231 A214E Thermonuclease Staphylococcus aureus 0.8 8.5 3.0 3.9 Unknown HEPES 10 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 9.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 15.605999946594238 20798341 10.1073/pnas.1004213107 2010 ProTherm 12892 6017 231 K215A Thermonuclease Staphylococcus aureus 0.62 1.4 4.2 0.97 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 30.232222663031685 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12893 6018 231 K215G Thermonuclease Staphylococcus aureus 0.34 3.3 2.3 0.92 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 30.232222663031685 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12953 6076 231 K215Q Thermonuclease Staphylococcus aureus 0.76 0.5 4.9 6.53 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 30.232222663031685 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 13375 6259 231 K215F Thermonuclease Staphylococcus aureus 0.66 1.4 4.1 0.93 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 30.232222663031685 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv 4261 2168 231 K216C Thermonuclease Staphylococcus aureus -2.9 yes 50.1 Sodium phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 35.506666607326935 8580845 10.1002/pro.5560041211 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 13610 2168 231 K216C Thermonuclease Staphylococcus aureus 0.73 0.7 4.8 6.57 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 35.506666607326935 8580845 10.1002/pro.5560041211 1995 ProTherm SAAFEC_S1262.csv 4269 2173 231 K216F Thermonuclease Staphylococcus aureus -1.7 yes 51.3 Sodium phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 35.506666607326935 8580845 10.1002/pro.5560041211 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 13376 2173 231 K216F Thermonuclease Staphylococcus aureus 0.82 0.5 5.0 0.93 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 35.506666607326935 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv 13618 2173 231 K216F Thermonuclease Staphylococcus aureus 0.81 0.3 5.2 6.39 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 35.506666607326935 8580845 10.1002/pro.5560041211 1995 ProTherm SAAFEC_S983.csv 12894 6019 231 K216A Thermonuclease Staphylococcus aureus 0.82 -0.1 5.7 1.01 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 35.506666607326935 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 12895 6020 231 K216G Thermonuclease Staphylococcus aureus 0.67 0.7 4.9 1.04 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 35.506666607326935 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 2461 1297 231 E217F Thermonuclease Staphylococcus aureus 81.0 -3.5 Unknown 49.2 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 16.931111335754395 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 2556 1297 231 E217F Thermonuclease Staphylococcus aureus 76.0 -3.5 Unknown 49.5 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 16.931111335754395 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 13377 1297 231 E217F Thermonuclease Staphylococcus aureus 0.68 1.2 4.3 0.96 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 16.931111335754395 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv 12848 5975 231 E217A Thermonuclease Staphylococcus aureus 0.69 0.7 4.9 1.02 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 16.931111335754395 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12849 5976 231 E217G Thermonuclease Staphylococcus aureus 0.57 1.7 3.9 0.97 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 16.931111335754395 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12954 6077 231 E217K Thermonuclease Staphylococcus aureus 0.63 1.1 4.3 6.8 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 16.931111335754395 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv 12955 6078 231 E217Q Thermonuclease Staphylococcus aureus 0.71 0.7 4.7 6.6 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 16.931111335754395 12549934 10.1021/bi0266434 2003 ProTherm SAAFEC_S1262.csv 2462 1298 231 K218F Thermonuclease Staphylococcus aureus 74.0 -6.4 Unknown 46.3 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 34.79555553860135 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 2557 1298 231 K218F Thermonuclease Staphylococcus aureus 72.0 -5.5 Unknown 47.5 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 34.79555553860135 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, STRUM_Q3421.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 13378 1298 231 K218F Thermonuclease Staphylococcus aureus 0.72 1.2 4.3 0.91 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 34.79555553860135 9578580 10.1021/bi9725069 1998 ProTherm SAAFEC_S1262.csv 12896 6021 231 K218A Thermonuclease Staphylococcus aureus 0.7 0.9 4.7 0.98 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 34.79555553860135 8639591 10.1021/bi960171+ 1996 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13550 6021 231 K218A Thermonuclease Staphylococcus aureus 0.7 0.7 4.7 1.02 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 34.79555553860135 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm SAAFEC_S983.csv 12897 6022 231 K218G Thermonuclease Staphylococcus aureus 0.78 0.2 5.4 1.0 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 34.79555553860135 8639591 10.1021/bi960171+ 1996 ProTherm potapov_with_uniprot_mapping.csv 13551 6022 231 K218G Thermonuclease Staphylococcus aureus 0.82 -0.1 5.5 1.01 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 4.0 1STN 34.79555553860135 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm guerios_625_map.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 3012 1607 231 L219A Thermonuclease Staphylococcus aureus -8.7 yes 45.3 Sodium phosphate 20 mM NaCl 100 mM DSC Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 18.25374984741211 7849061 10.1021/bi00006a025 1995 ProTherm Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1962.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 13419 1607 231 L219A Thermonuclease Staphylococcus aureus 0.5 2.3 3.18 0.95 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 18.25374984741211 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12775 5931 231 L219I Thermonuclease Staphylococcus aureus 0.71 0.8 4.6 6.5 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 18.25374984741211 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv 12776 5932 231 L219V Thermonuclease Staphylococcus aureus 0.6 1.4 4.0 6.58 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 18.25374984741211 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv 13420 6291 231 L219G Thermonuclease Staphylococcus aureus 0.1 4.6 0.88 0.74 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 3.0 1STN 18.25374984741211 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13062 6149 231 N220G Thermonuclease Staphylococcus aureus 0.95 -0.1 5.6 0.87 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 20.828750133514404 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 13587 6149 231 N220G Thermonuclease Staphylococcus aureus 0.95 -0.2 5.6 0.87 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 20.828750133514404 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 13063 6150 231 N220A Thermonuclease Staphylococcus aureus 0.67 1.1 4.4 0.97 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 20.828750133514404 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13586 6150 231 N220A Thermonuclease Staphylococcus aureus 0.67 1.0 4.4 0.97 Unknown Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 20.828750133514404 8289248 10.1016/s0022-2836(05)80008-7 1994 ProTherm SAAFEC_S1262.csv 12753 5909 231 I221L Thermonuclease Staphylococcus aureus 0.81 0.1 5.3 6.55 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 25.396250247955322 in pocket 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 12754 5910 231 I221M Thermonuclease Staphylococcus aureus 0.76 0.4 5.0 6.66 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 25.396250247955322 in pocket 11705391 10.1021/bi011267t 2001 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 13446 6312 231 I221V Thermonuclease Staphylococcus aureus 0.6 1.5 3.98 0.94 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 25.396250247955322 in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13447 6313 231 I221A Thermonuclease Staphylococcus aureus 0.3 3.5 1.98 0.85 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 25.396250247955322 in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 13448 6314 231 I221G Thermonuclease Staphylococcus aureus 0.2 4.4 1.08 0.73 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 25.396250247955322 in pocket 2261461 10.1021/bi00487a007 1990 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 1487 859 231 W222H Thermonuclease Staphylococcus aureus 82.2 yes 59.0 sodium phosphate 25mM NaCl 50 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 22.261428696768625 in pocket 15066439 10.1016/j.jmb.2004.02.044 2004 ProTherm 1803 859 231 W222H Thermonuclease Staphylococcus aureus 59.03 -8.9 Unknown 41.8 MOPS 10 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 22.261428696768625 in pocket 15573380 10.1002/prot.20333 2005 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, HotMuSiC_S1626.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 12973 859 231 W222H Thermonuclease Staphylococcus aureus 0.4 5.7 yes sodium phosphate 25mM 20.0 NaCl 50 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 22.261428696768625 in pocket 15066439 10.1016/j.jmb.2004.02.044 2004 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1488 860 231 W222F Thermonuclease Staphylococcus aureus 81.0 yes 56.9 sodium phosphate 25mM NaCl 50 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 22.261428696768625 in pocket 15066439 10.1016/j.jmb.2004.02.044 2004 ProTherm 1801 860 231 W222F Thermonuclease Staphylococcus aureus 47.8 -11.6 Unknown 39.1 MOPS 10 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 22.261428696768625 in pocket 15573380 10.1002/prot.20333 2005 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S499.csv 12974 860 231 W222F Thermonuclease Staphylococcus aureus 0.6 5.5 yes sodium phosphate 25mM 20.0 NaCl 50 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 22.261428696768625 in pocket 15066439 10.1016/j.jmb.2004.02.044 2004 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1489 861 231 W222Y Thermonuclease Staphylococcus aureus 76.8 yes 56.4 sodium phosphate 25mM NaCl 50 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 22.261428696768625 in pocket 15066439 10.1016/j.jmb.2004.02.044 2004 ProTherm 1802 861 231 W222Y Thermonuclease Staphylococcus aureus 49.0 -12.1 Unknown 38.6 MOPS 10 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 22.261428696768625 in pocket 15573380 10.1002/prot.20333 2005 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S499.csv, PoPMuSiC-2.0_S2648.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 12975 861 231 W222Y Thermonuclease Staphylococcus aureus 1.1 5.0 yes sodium phosphate 25mM 20.0 NaCl 50 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 22.261428696768625 in pocket 15066439 10.1016/j.jmb.2004.02.044 2004 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1490 862 231 W222L Thermonuclease Staphylococcus aureus 42.0 yes 43.6 sodium phosphate 25mM NaCl 50 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 22.261428696768625 in pocket 15066439 10.1016/j.jmb.2004.02.044 2004 ProTherm 12976 862 231 W222L Thermonuclease Staphylococcus aureus 4.5 1.6 yes sodium phosphate 25mM 20.0 NaCl 50 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 22.261428696768625 in pocket 15066439 10.1016/j.jmb.2004.02.044 2004 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 10523 4440 231 W222A Thermonuclease Staphylococcus aureus 0.15 Unknown Phosphate 25.0 Fluorescence GdnHCl 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 22.261428696768625 in pocket 20688426 10.1016/j.bpc.2010.07.001 2010 ProTherm 10524 4440 231 W222A Thermonuclease Staphylococcus aureus 0.45 Unknown Phosphate 25.0 CD GdnHCl 5.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 22.261428696768625 in pocket 20688426 10.1016/j.bpc.2010.07.001 2010 ProTherm 10525 4440 231 W222A Thermonuclease Staphylococcus aureus 0.15 Unknown Tris-HCl 25 mM 25.0 Calcium chloride 10 mM Fluorescence Activity 8.8 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 22.261428696768625 in pocket 20688426 10.1016/j.bpc.2010.07.001 2010 ProTherm 1602 901 231 S223A Thermonuclease Staphylococcus aureus 67.6 -0.8 Unknown 50.4 MOPS 10 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 31.60666624704997 12211005 10.1002/prot.10216 2002 ProTherm 2406 901 231 S223A Thermonuclease Staphylococcus aureus 86.0 -1.3 Unknown 51.4 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 31.60666624704997 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm HotMuSiC_S1626.csv, AUTOMUTE_S1962.csv, Saraboji_S2204.csv 2501 901 231 S223A Thermonuclease Staphylococcus aureus 82.0 -0.4 Unknown 52.6 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 31.60666624704997 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 8097 901 231 S223A Thermonuclease Staphylococcus aureus 0.12 2.13 Unknown MOPS 10 mM 40.0 CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 31.60666624704997 12211005 10.1002/prot.10216 2002 ProTherm khan_protherm_data_mapped.csv 13080 901 231 S223A Thermonuclease Staphylococcus aureus 0.75 0.4 5.1 1.0 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 31.60666624704997 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv, SAAFEC_S983.csv 13079 6164 231 S223G Thermonuclease Staphylococcus aureus 0.69 0.9 4.6 0.98 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 9.0 1STN 31.60666624704997 1610820 10.1021/bi00140a005 1992 ProTherm guerios_625_map.csv, potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 12850 5977 231 E224A Thermonuclease Staphylococcus aureus 0.76 0.3 5.3 1.01 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 8639591 10.1021/bi960171+ 1996 ProTherm 12851 5978 231 E224G Thermonuclease Staphylococcus aureus 0.76 0.3 5.3 1.01 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 5.0 1STN 8639591 10.1021/bi960171+ 1996 ProTherm 2463 1299 231 D225F Thermonuclease Staphylococcus aureus 91.0 -1.5 Unknown 51.2 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm Broom_S605.csv 2558 1299 231 D225F Thermonuclease Staphylococcus aureus 85.0 0.1 Unknown 53.1 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S499.csv 13379 1299 231 D225F Thermonuclease Staphylococcus aureus 0.83 0.1 5.4 0.98 yes Sodium phosphate 25 mM 20.0 NaCl 600 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 9578580 10.1021/bi9725069 1998 ProTherm 12824 5954 231 D225A Thermonuclease Staphylococcus aureus 0.79 0.1 5.5 1.01 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 8639591 10.1021/bi960171+ 1996 ProTherm 12825 5955 231 D225G Thermonuclease Staphylococcus aureus 0.79 0.2 5.4 0.98 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 8639591 10.1021/bi960171+ 1996 ProTherm 12956 6079 231 D225K Thermonuclease Staphylococcus aureus 0.78 0.3 5.1 6.47 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12549934 10.1021/bi0266434 2003 ProTherm 12957 6080 231 D225N Thermonuclease Staphylococcus aureus 0.8 0.3 5.1 6.34 Unknown sodium phosphate 25 mM 20.0 sodium chloride 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 12549934 10.1021/bi0266434 2003 ProTherm 13022 6111 231 A227G Thermonuclease Staphylococcus aureus 0.8 0.4 5.1 0.94 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 1610820 10.1021/bi00140a005 1992 ProTherm 13023 6112 231 A227V Thermonuclease Staphylococcus aureus 0.79 0.3 5.2 0.96 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 1610820 10.1021/bi00140a005 1992 ProTherm 12826 5956 231 D228A Thermonuclease Staphylococcus aureus 0.78 0.2 5.4 0.99 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 8639591 10.1021/bi960171+ 1996 ProTherm 12827 5957 231 D228G Thermonuclease Staphylococcus aureus 0.78 0.2 5.4 1.01 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 6.0 1STN 8639591 10.1021/bi960171+ 1996 ProTherm 2407 1243 231 S229A Thermonuclease Staphylococcus aureus 85.0 -0.6 Unknown 52.1 Phosphate 25 mM NaCl 100 mM CD Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv 2502 1243 231 S229A Thermonuclease Staphylococcus aureus 87.0 0.5 Unknown 53.5 Phosphate 25 mM NaCl 100 mM Fluorescence Thermal 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 8.0 1STN 17134819 10.1016/j.bpc.2006.10.014 2007 ProTherm 13074 6161 231 Q231G Thermonuclease Staphylococcus aureus 0.78 0.4 5.1 0.95 yes Sodium phosphate 25 mM 20.0 NaCl 100 mM Fluorescence GdnHCl 7.0 3.1.31.1 P00644 IPR035437:SNase_OB-fold_sf, IPR016071:Staphylococal_nuclease_OB-fold, IPR002071:Thermonucl_AS 7.0 1STN 1610820 10.1021/bi00140a005 1992 ProTherm 18364 126 109 Thioredoxin 1 Escherichia coli (strain K12) 1.9 yes 85.3 Sodium phosphate 50 mM DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7857925 10.1021/bi00007a007 1995 ProTherm 18538 126 109 Thioredoxin 1 Escherichia coli (strain K12) yes 82.0 phosphate 50 mM CD Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 3552046 10.1021/bi00379a029 1987 ProTherm 18707 126 109 Thioredoxin 1 Escherichia coli (strain K12) 106.9 yes 87.0 phosphate 0.01 M NaCl 0.1 M DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 1591250 10.1021/bi00135a022 1992 ProTherm 18774 126 109 Thioredoxin 1 Escherichia coli (strain K12) 1.93 67.78 yes 74.01 Sodium phosphate 50 mM DSC Thermal 6.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 8142367 10.1021/bi00178a027 1994 ProTherm 18775 126 109 Thioredoxin 1 Escherichia coli (strain K12) 2.07 76.11 yes 73.34 Sodium phosphate 50 mM DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 8142367 10.1021/bi00178a027 1994 ProTherm 18795 126 109 Thioredoxin 1 Escherichia coli (strain K12) 0.98 83.4 101.7 yes 88.44 Sodium phosphate 50 mM DSC Thermal 6.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 8393344 10.1021/bi00080a026 1993 ProTherm 18796 126 109 Thioredoxin 1 Escherichia coli (strain K12) 1.76 106.12 106.12 yes 86.43 Sodium phosphate 50 mM DSC Thermal 6.5 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 8393344 10.1021/bi00080a026 1993 ProTherm 18797 126 109 Thioredoxin 1 Escherichia coli (strain K12) 1.45 94.54 112.5 yes 85.33 Sodium phosphate 50 mM DSC Thermal 6.75 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 8393344 10.1021/bi00080a026 1993 ProTherm 18798 126 109 Thioredoxin 1 Escherichia coli (strain K12) 1.3 96.53 110.0 yes 86.01 Sodium phosphate 50 mM DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 8393344 10.1021/bi00080a026 1993 ProTherm 18799 126 109 Thioredoxin 1 Escherichia coli (strain K12) 0.95 96.76 118.0 yes 85.05 Sodium phosphate 50 mM DSC Thermal 7.25 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 8393344 10.1021/bi00080a026 1993 ProTherm 18800 126 109 Thioredoxin 1 Escherichia coli (strain K12) 1.9 97.34 120.7 yes 83.48 Sodium phosphate 50 mM DSC Thermal 7.5 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 8393344 10.1021/bi00080a026 1993 ProTherm 18801 126 109 Thioredoxin 1 Escherichia coli (strain K12) 2.28 91.26 119.6 yes 83.9 Sodium phosphate 50 mM DSC Thermal 7.75 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 8393344 10.1021/bi00080a026 1993 ProTherm 18802 126 109 Thioredoxin 1 Escherichia coli (strain K12) 3.84 85.88 119.4 yes 83.3 Sodium phosphate 50 mM DSC Thermal 8.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 8393344 10.1021/bi00080a026 1993 ProTherm 20502 126 109 Thioredoxin 1 Escherichia coli (strain K12) 1.66 8.9 yes phosphate 0.01 M 25.0 NaCl 0.1 M DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 1591250 10.1021/bi00135a022 1992 ProTherm 20749 126 109 Thioredoxin 1 Escherichia coli (strain K12) 7.4 10.0 Unknown Tris 0.375 M 25.0 CD Urea 8.7 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 2663067 10.1021/bi00434a015 1989 ProTherm 20750 126 109 Thioredoxin 1 Escherichia coli (strain K12) 4.4 6.5 Unknown Tris 0.375 M 25.0 CD Urea 8.7 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 2663067 10.1021/bi00434a015 1989 ProTherm 20762 126 109 Thioredoxin 1 Escherichia coli (strain K12) 2.6 8.6 yes phosphate 50 mM 25.0 CD GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 3552046 10.1021/bi00379a029 1987 ProTherm 20763 126 109 Thioredoxin 1 Escherichia coli (strain K12) 6.7 8.7 yes phosphate 50 mM 25.0 CD Urea 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 3552046 10.1021/bi00379a029 1987 ProTherm 20764 126 109 Thioredoxin 1 Escherichia coli (strain K12) 1.8 6.2 yes phosphate 50 mM 25.0 CD GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 3552046 10.1021/bi00379a029 1987 ProTherm 20776 126 109 Thioredoxin 1 Escherichia coli (strain K12) 8.9 Unknown Potassium phosphate 50 mM 25.0 CD GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 3322388 10.1021/bi00395a028 1987 ProTherm 20787 126 109 Thioredoxin 1 Escherichia coli (strain K12) 8.6 2.1 Unknown Tris 50 mM 25.0 CD GdnHCl 9.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 1854757 10.1021/bi00244a032 1991 ProTherm 20788 126 109 Thioredoxin 1 Escherichia coli (strain K12) 8.6 2.1 Unknown Tris 50 mM 25.0 CD GdnHCl 8.5 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 1854757 10.1021/bi00244a032 1991 ProTherm 20789 126 109 Thioredoxin 1 Escherichia coli (strain K12) 8.8 2.2 Unknown Tris 50 mM 25.0 CD GdnHCl 8.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 1854757 10.1021/bi00244a032 1991 ProTherm 20790 126 109 Thioredoxin 1 Escherichia coli (strain K12) 9.0 2.2 Unknown TES 50 mM 25.0 CD GdnHCl 7.5 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 1854757 10.1021/bi00244a032 1991 ProTherm 20791 126 109 Thioredoxin 1 Escherichia coli (strain K12) 9.5 2.3 Unknown TES 50 mM 25.0 CD GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 1854757 10.1021/bi00244a032 1991 ProTherm 20792 126 109 Thioredoxin 1 Escherichia coli (strain K12) 10.0 2.4 Unknown ACES 50 mM 25.0 CD GdnHCl 6.5 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 1854757 10.1021/bi00244a032 1991 ProTherm 20793 126 109 Thioredoxin 1 Escherichia coli (strain K12) 10.6 2.6 Unknown ACES 50 mM 25.0 CD GdnHCl 6.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 1854757 10.1021/bi00244a032 1991 ProTherm 20797 126 109 Thioredoxin 1 Escherichia coli (strain K12) 2.22 7.8 3.51 yes MOPS 0.05 M 25.0 DSC GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 1591250 10.1021/bi00135a022 1992 ProTherm 20798 126 109 Thioredoxin 1 Escherichia coli (strain K12) 6.57 8.6 1.32 yes MOPS 0.05 M 25.0 NaCl 0.5 M DSC Urea 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 1591250 10.1021/bi00135a022 1992 ProTherm 21466 126 109 Thioredoxin 1 Escherichia coli (strain K12) 6.1 yes Tris 0.1 M 23.0 KCl 0.2 M Absorbance Urea 8.7 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 1961723 10.1073/pnas.88.23.10573 1991 ProTherm 21467 126 109 Thioredoxin 1 Escherichia coli (strain K12) 9.7 yes Tris 0.1 M 23.0 KCl 0.2 M Absorbance Urea 8.7 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 1961723 10.1073/pnas.88.23.10573 1991 ProTherm 21487 126 109 Thioredoxin 1 Escherichia coli (strain K12) 5.0 yes Tris-HCl 0.1 M 23.0 KCl 0.2 M CD GdnHCl 8.7 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 2669972 10.1021/bi00438a054 1989 ProTherm 21488 126 109 Thioredoxin 1 Escherichia coli (strain K12) 8.1 yes Tris-HCl 0.1 M 23.0 KCl 0.2 M CD GdnHCl 8.7 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 2669972 10.1021/bi00438a054 1989 ProTherm 21735 126 109 Thioredoxin 1 Escherichia coli (strain K12) 2.61 9.5 3.7 yes Potassium phosphate 10 mM 20.0 CD GdnHCl 5.7 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 10529211 10.1021/bi990498l 1999 ProTherm 22318 126 109 Thioredoxin 1 Escherichia coli (strain K12) Unknown 87.0 sodium phosphate 50 mM CD Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 11513583 10.1021/bi010427y 2001 ProTherm 23013 126 109 Thioredoxin 1 Escherichia coli (strain K12) yes 89.8 citrate, glycine, HEPES 10 mM, 10mM, 10 mM DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 16262263 10.1021/bi050921s 2005 ProTherm 23014 126 109 Thioredoxin 1 Escherichia coli (strain K12) yes 75.3 citrate, glycine, HEPES 10 mM, 10mM, 10 mM DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 16262263 10.1021/bi050921s 2005 ProTherm 24390 126 109 Thioredoxin 1 Escherichia coli (strain K12) 1.39 102.77 no 2.0 89.05 Hepes 5 mM DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 16935299 10.1016/j.jmb.2006.07.065 2006 ProTherm 25023 126 109 Thioredoxin 1 Escherichia coli (strain K12) 112.0 no 87.3 CGH-10 DSC Thermal 7.4 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 23667620 10.1371/journal.pone.0063442 2013 ProTherm 25672 126 109 Thioredoxin 1 Escherichia coli (strain K12) 2.5 7.9 3.2 Unknown Potassium phosphate 10 mM 25.0 CD GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 11551217 10.1021/bi010745x 2001 ProTherm 25673 126 109 Thioredoxin 1 Escherichia coli (strain K12) 2.6 9.0 3.4 Unknown sodium phosphate 50 mM 25.0 CD GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 11513583 10.1021/bi010427y 2001 ProTherm 25952 126 109 Thioredoxin 1 Escherichia coli (strain K12) 2.5 9.6 Unknown sodium phosphate 30 mM 25.0 KCl 0.1 M CD GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 12876321 10.1110/ps.0239503 2003 ProTherm 25953 126 109 Thioredoxin 1 Escherichia coli (strain K12) 2.5 9.6 Unknown sodium phosphate 30 mM 25.0 KCl 0.1 M Fluorescence GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 12876321 10.1110/ps.0239503 2003 ProTherm 26039 126 109 Thioredoxin 1 Escherichia coli (strain K12) 2.6 9.6 3.7 yes phosphate 10 mM 25.0 Fluorescence GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 16262263 10.1021/bi050921s 2005 ProTherm 26040 126 109 Thioredoxin 1 Escherichia coli (strain K12) 1.7 6.2 3.6 yes phosphate 10 mM 25.0 Fluorescence GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 16262263 10.1021/bi050921s 2005 ProTherm 26629 126 109 Thioredoxin 1 Escherichia coli (strain K12) 6.92 1.28 no 2.0 Hepes 5 mM 25.0 fluorescence Urea 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 16935299 10.1016/j.jmb.2006.07.065 2006 ProTherm 26783 126 109 Thioredoxin 1 Escherichia coli (strain K12) 8.9 no CGH-10 25.0 DSC GdnHCl 7.4 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 23667620 10.1371/journal.pone.0063442 2013 ProTherm 11528 4946 109 D3E Thioredoxin 1 Escherichia coli (strain K12) -0.1 no 2.0 Hepes 5 mM 25.0 fluorescence Urea 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 3.0 2TRX, 2H6X 22.12874960899353, 65.072500705719 in pocket 16935299 10.1016/j.jmb.2006.07.065 2006 ProTherm 11541 4958 109 I6V Thioredoxin 1 Escherichia coli (strain K12) 1.1 no 2.0 Hepes 5 mM 25.0 fluorescence Urea 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 3.0 2TRX, 2H6X 16.547500014305115, 39.198750019073486 in pocket 16935299 10.1016/j.jmb.2006.07.065 2006 ProTherm 11542 4958 109 I6V Thioredoxin 1 Escherichia coli (strain K12) 2.9 no 2.0 Hepes 5 mM 25.0 fluorescence Urea 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 3.0 2TRX, 2H6X 16.547500014305115, 39.198750019073486 in pocket 16935299 10.1016/j.jmb.2006.07.065 2006 ProTherm 11529 4947 109 D11E Thioredoxin 1 Escherichia coli (strain K12) 5.83 5.7 1.22 no 2.0 Hepes 5 mM 25.0 fluorescence Urea 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 2.0 2TRX, 2H6X 16.52625012397766, 43.88499975204468 16935299 10.1016/j.jmb.2006.07.065 2006 ProTherm 11530 4947 109 D11E Thioredoxin 1 Escherichia coli (strain K12) 0.7 no 2.0 Hepes 5 mM 25.0 fluorescence Urea 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 2.0 2TRX, 2H6X 16.52625012397766, 43.88499975204468 16935299 10.1016/j.jmb.2006.07.065 2006 ProTherm 11531 4948 109 D14E Thioredoxin 1 Escherichia coli (strain K12) -0.8 no 2.0 Hepes 5 mM 25.0 fluorescence Urea 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 4.0 2TRX, 2H6X 19.823750138282776, 38.47000074386597 16935299 10.1016/j.jmb.2006.07.065 2006 ProTherm 11550 4966 109 V17I Thioredoxin 1 Escherichia coli (strain K12) 6.27 3.4 1.24 no 2.0 Hepes 5 mM 25.0 fluorescence Urea 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7.0 2TRX, 2H6X 11.56714289528983, 34.21714292253767 16935299 10.1016/j.jmb.2006.07.065 2006 ProTherm 11543 4959 109 I24V Thioredoxin 1 Escherichia coli (strain K12) -1.1 no 2.0 Hepes 5 mM 25.0 fluorescence Urea 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 8.0 2TRX, 2H6X 10.776250004768372, 34.797499656677246 16935299 10.1016/j.jmb.2006.07.065 2006 ProTherm 11551 4967 109 V26I Thioredoxin 1 Escherichia coli (strain K12) 3.8 no 2.0 Hepes 5 mM 25.0 fluorescence Urea 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 9.0 2TRX, 2H6X 8.638571330479213, 28.59714262826102 16935299 10.1016/j.jmb.2006.07.065 2006 ProTherm 462 256 109 D27I Thioredoxin 1 Escherichia coli (strain K12) Unknown 98.0 sodium phosphate 50 mM CD Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 9.0 2TRX, 2H6X 11.62250006198883, 31.50749969482422 in tunnel in pocket 11513583 10.1021/bi010427y 2001 ProTherm 8757 256 109 D27I Thioredoxin 1 Escherichia coli (strain K12) 3.7 -12.1 3.3 Unknown sodium phosphate 50 mM 25.0 CD GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 9.0 2TRX, 2H6X 11.62250006198883, 31.50749969482422 in tunnel in pocket 11513583 10.1021/bi010427y 2001 ProTherm 10745 4566 109 D27A Thioredoxin 1 Escherichia coli (strain K12) -4.6 13.2 3.2 Unknown Tris 50 mM 25.0 CD GdnHCl 8.5 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 9.0 2TRX, 2H6X 11.62250006198883, 31.50749969482422 in tunnel in pocket 1854757 10.1021/bi00244a032 1991 ProTherm 10746 4566 109 D27A Thioredoxin 1 Escherichia coli (strain K12) -4.4 13.2 3.2 Unknown Tris 50 mM 25.0 CD GdnHCl 8.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 9.0 2TRX, 2H6X 11.62250006198883, 31.50749969482422 in tunnel in pocket 1854757 10.1021/bi00244a032 1991 ProTherm 10747 4566 109 D27A Thioredoxin 1 Escherichia coli (strain K12) -4.2 13.2 3.2 Unknown TES 50 mM 25.0 CD GdnHCl 7.5 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 9.0 2TRX, 2H6X 11.62250006198883, 31.50749969482422 in tunnel in pocket 1854757 10.1021/bi00244a032 1991 ProTherm SAAFEC_S1262.csv 10748 4566 109 D27A Thioredoxin 1 Escherichia coli (strain K12) -3.7 13.2 3.2 Unknown TES 50 mM 25.0 CD GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 9.0 2TRX, 2H6X 11.62250006198883, 31.50749969482422 in tunnel in pocket 1854757 10.1021/bi00244a032 1991 ProTherm 11536 4953 109 E31D Thioredoxin 1 Escherichia coli (strain K12) 0.9 no 2.0 Hepes 5 mM 25.0 fluorescence Urea 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 3.0 2TRX, 2H6X 33.84111107720269, 35.594444274902344 in pocket 16935299 10.1016/j.jmb.2006.07.065 2006 ProTherm 463 257 109 C33A Thioredoxin 1 Escherichia coli (strain K12) Unknown 74.0 sodium phosphate 50 mM CD Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain Nucleophile 9.0 2TRX, 2H6X 19.381666501363117, 39.85333379109701 in pocket 11513583 10.1021/bi010427y 2001 ProTherm 8758 257 109 C33A Thioredoxin 1 Escherichia coli (strain K12) 1.6 -5.3 3.4 Unknown sodium phosphate 50 mM 25.0 CD GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain Nucleophile 9.0 2TRX, 2H6X 19.381666501363117, 39.85333379109701 in pocket 11513583 10.1021/bi010427y 2001 ProTherm SAAFEC_S1262.csv 14723 6889 109 C33S, C36S Thioredoxin 1 Escherichia coli (strain K12) 1.07 50.43 3.05 yes 77.06 Sodium phosphate 50 mM DSC Thermal 6.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain Nucleophile, Nucleophile 9.0, 9.0 2TRX, 2H6X 19.381666501363117, 17.433333079020183, 39.85333379109701, 39.33500099182129 in tunnel in pocket 8142367 10.1021/bi00178a027 1994 ProTherm 14724 6889 109 C33S, C36S Thioredoxin 1 Escherichia coli (strain K12) 2.29 89.24 1.15 yes 74.49 Sodium phosphate 50 mM DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain Nucleophile, Nucleophile 9.0, 9.0 2TRX, 2H6X 19.381666501363117, 17.433333079020183, 39.85333379109701, 39.33500099182129 in tunnel in pocket 8142367 10.1021/bi00178a027 1994 ProTherm 14725 6889 109 C33S, C36S Thioredoxin 1 Escherichia coli (strain K12) 2.43 84.83 yes 72.29 Sodium phosphate 50 mM DSC Thermal 8.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain Nucleophile, Nucleophile 9.0, 9.0 2TRX, 2H6X 19.381666501363117, 17.433333079020183, 39.85333379109701, 39.33500099182129 in tunnel in pocket 8142367 10.1021/bi00178a027 1994 ProTherm 14839 6976 109 C33S, C36S, L79C Thioredoxin 1 Escherichia coli (strain K12) 62.6 yes 65.24 Sodium phosphate 50 mM DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain Nucleophile, Nucleophile 9.0, 9.0, 7.0 2TRX, 2H6X 19.381666501363117, 17.433333079020183, 11.567499876022339, 39.85333379109701, 39.33500099182129, 26.56375002861023 in tunnel in pocket 9194193 10.1002/pro.5560060621 1997 ProTherm 14840 6976 109 C33S, C36S, L79C Thioredoxin 1 Escherichia coli (strain K12) 84.6 yes 65.2 Sodium phosphate 50 mM DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain Nucleophile, Nucleophile 9.0, 9.0, 7.0 2TRX, 2H6X 19.381666501363117, 17.433333079020183, 11.567499876022339, 39.85333379109701, 39.33500099182129, 26.56375002861023 in tunnel in pocket 9194193 10.1002/pro.5560060621 1997 ProTherm 14841 6976 109 C33S, C36S, L79C Thioredoxin 1 Escherichia coli (strain K12) 86.7 yes 66.91 Sodium phosphate 50 mM DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain Nucleophile, Nucleophile 9.0, 9.0, 7.0 2TRX, 2H6X 19.381666501363117, 17.433333079020183, 11.567499876022339, 39.85333379109701, 39.33500099182129, 26.56375002861023 in tunnel in pocket 9194193 10.1002/pro.5560060621 1997 ProTherm 14842 6976 109 C33S, C36S, L79C Thioredoxin 1 Escherichia coli (strain K12) 74.1 yes 66.3 Sodium phosphate 50 mM DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain Nucleophile, Nucleophile 9.0, 9.0, 7.0 2TRX, 2H6X 19.381666501363117, 17.433333079020183, 11.567499876022339, 39.85333379109701, 39.33500099182129, 26.56375002861023 in tunnel in pocket 9194193 10.1002/pro.5560060621 1997 ProTherm 14843 6976 109 C33S, C36S, L79C Thioredoxin 1 Escherichia coli (strain K12) 1.87 100.5 yes 69.33 Sodium phosphate 50 mM DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain Nucleophile, Nucleophile 9.0, 9.0, 7.0 2TRX, 2H6X 19.381666501363117, 17.433333079020183, 11.567499876022339, 39.85333379109701, 39.33500099182129, 26.56375002861023 in tunnel in pocket 9194193 10.1002/pro.5560060621 1997 ProTherm 14844 6976 109 C33S, C36S, L79C Thioredoxin 1 Escherichia coli (strain K12) 1.86 106.9 yes 69.36 Sodium phosphate 50 mM DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain Nucleophile, Nucleophile 9.0, 9.0, 7.0 2TRX, 2H6X 19.381666501363117, 17.433333079020183, 11.567499876022339, 39.85333379109701, 39.33500099182129, 26.56375002861023 in tunnel in pocket 9194193 10.1002/pro.5560060621 1997 ProTherm 14845 6976 109 C33S, C36S, L79C Thioredoxin 1 Escherichia coli (strain K12) 0.96 94.5 yes 69.74 Sodium phosphate 50 mM DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain Nucleophile, Nucleophile 9.0, 9.0, 7.0 2TRX, 2H6X 19.381666501363117, 17.433333079020183, 11.567499876022339, 39.85333379109701, 39.33500099182129, 26.56375002861023 in tunnel in pocket 9194193 10.1002/pro.5560060621 1997 ProTherm 14846 6976 109 C33S, C36S, L79C Thioredoxin 1 Escherichia coli (strain K12) 1.45 94.0 yes 69.34 Sodium phosphate 50 mM DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain Nucleophile, Nucleophile 9.0, 9.0, 7.0 2TRX, 2H6X 19.381666501363117, 17.433333079020183, 11.567499876022339, 39.85333379109701, 39.33500099182129, 26.56375002861023 in tunnel in pocket 9194193 10.1002/pro.5560060621 1997 ProTherm 14847 6976 109 C33S, C36S, L79C Thioredoxin 1 Escherichia coli (strain K12) 1.24 97.6 yes 69.65 Sodium phosphate 50 mM DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain Nucleophile, Nucleophile 9.0, 9.0, 7.0 2TRX, 2H6X 19.381666501363117, 17.433333079020183, 11.567499876022339, 39.85333379109701, 39.33500099182129, 26.56375002861023 in tunnel in pocket 9194193 10.1002/pro.5560060621 1997 ProTherm 14848 6976 109 C33S, C36S, L79C Thioredoxin 1 Escherichia coli (strain K12) 1.48 97.1 yes 69.69 Sodium phosphate 50 mM DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain Nucleophile, Nucleophile 9.0, 9.0, 7.0 2TRX, 2H6X 19.381666501363117, 17.433333079020183, 11.567499876022339, 39.85333379109701, 39.33500099182129, 26.56375002861023 in tunnel in pocket 9194193 10.1002/pro.5560060621 1997 ProTherm 14849 6976 109 C33S, C36S, L79C Thioredoxin 1 Escherichia coli (strain K12) 1.55 96.8 yes 69.8 Sodium phosphate 50 mM DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain Nucleophile, Nucleophile 9.0, 9.0, 7.0 2TRX, 2H6X 19.381666501363117, 17.433333079020183, 11.567499876022339, 39.85333379109701, 39.33500099182129, 26.56375002861023 in tunnel in pocket 9194193 10.1002/pro.5560060621 1997 ProTherm 14850 6976 109 C33S, C36S, L79C Thioredoxin 1 Escherichia coli (strain K12) 3.06 67.0 yes 67.3 Sodium phosphate 50 mM DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain Nucleophile, Nucleophile 9.0, 9.0, 7.0 2TRX, 2H6X 19.381666501363117, 17.433333079020183, 11.567499876022339, 39.85333379109701, 39.33500099182129, 26.56375002861023 in tunnel in pocket 9194193 10.1002/pro.5560060621 1997 ProTherm 14851 6976 109 C33S, C36S, L79C Thioredoxin 1 Escherichia coli (strain K12) 1.86 76.4 yes 69.25 Sodium phosphate 50 mM DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain Nucleophile, Nucleophile 9.0, 9.0, 7.0 2TRX, 2H6X 19.381666501363117, 17.433333079020183, 11.567499876022339, 39.85333379109701, 39.33500099182129, 26.56375002861023 in tunnel in pocket 9194193 10.1002/pro.5560060621 1997 ProTherm 14852 6976 109 C33S, C36S, L79C Thioredoxin 1 Escherichia coli (strain K12) 0.41 102.0 yes 70.34 Sodium phosphate 50 mM DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain Nucleophile, Nucleophile 9.0, 9.0, 7.0 2TRX, 2H6X 19.381666501363117, 17.433333079020183, 11.567499876022339, 39.85333379109701, 39.33500099182129, 26.56375002861023 in tunnel in pocket 9194193 10.1002/pro.5560060621 1997 ProTherm 14853 6976 109 C33S, C36S, L79C Thioredoxin 1 Escherichia coli (strain K12) 1.87 53.5 yes 63.07 Sodium phosphate 50 mM DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain Nucleophile, Nucleophile 9.0, 9.0, 7.0 2TRX, 2H6X 19.381666501363117, 17.433333079020183, 11.567499876022339, 39.85333379109701, 39.33500099182129, 26.56375002861023 in tunnel in pocket 9194193 10.1002/pro.5560060621 1997 ProTherm 14854 6976 109 C33S, C36S, L79C Thioredoxin 1 Escherichia coli (strain K12) 2.19 52.9 yes 63.72 Sodium phosphate 50 mM DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain Nucleophile, Nucleophile 9.0, 9.0, 7.0 2TRX, 2H6X 19.381666501363117, 17.433333079020183, 11.567499876022339, 39.85333379109701, 39.33500099182129, 26.56375002861023 in tunnel in pocket 9194193 10.1002/pro.5560060621 1997 ProTherm 14855 6976 109 C33S, C36S, L79C Thioredoxin 1 Escherichia coli (strain K12) 2.18 56.5 yes 65.49 Sodium phosphate 50 mM DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain Nucleophile, Nucleophile 9.0, 9.0, 7.0 2TRX, 2H6X 19.381666501363117, 17.433333079020183, 11.567499876022339, 39.85333379109701, 39.33500099182129, 26.56375002861023 in tunnel in pocket 9194193 10.1002/pro.5560060621 1997 ProTherm 14856 6976 109 C33S, C36S, L79C Thioredoxin 1 Escherichia coli (strain K12) 2.8 71.8 yes 62.63 Sodium phosphate 50 mM DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain Nucleophile, Nucleophile 9.0, 9.0, 7.0 2TRX, 2H6X 19.381666501363117, 17.433333079020183, 11.567499876022339, 39.85333379109701, 39.33500099182129, 26.56375002861023 in tunnel in pocket 9194193 10.1002/pro.5560060621 1997 ProTherm 14857 6976 109 C33S, C36S, L79C Thioredoxin 1 Escherichia coli (strain K12) 2.45 51.0 yes 63.43 Sodium phosphate 50 mM DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain Nucleophile, Nucleophile 9.0, 9.0, 7.0 2TRX, 2H6X 19.381666501363117, 17.433333079020183, 11.567499876022339, 39.85333379109701, 39.33500099182129, 26.56375002861023 in tunnel in pocket 9194193 10.1002/pro.5560060621 1997 ProTherm 14858 6976 109 C33S, C36S, L79C Thioredoxin 1 Escherichia coli (strain K12) 0.85 84.6 yes 69.59 Sodium phosphate 50 mM DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain Nucleophile, Nucleophile 9.0, 9.0, 7.0 2TRX, 2H6X 19.381666501363117, 17.433333079020183, 11.567499876022339, 39.85333379109701, 39.33500099182129, 26.56375002861023 in tunnel in pocket 9194193 10.1002/pro.5560060621 1997 ProTherm 14859 6976 109 C33S, C36S, L79C Thioredoxin 1 Escherichia coli (strain K12) 1.54 81.1 yes 69.56 Sodium phosphate 50 mM DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain Nucleophile, Nucleophile 9.0, 9.0, 7.0 2TRX, 2H6X 19.381666501363117, 17.433333079020183, 11.567499876022339, 39.85333379109701, 39.33500099182129, 26.56375002861023 in tunnel in pocket 9194193 10.1002/pro.5560060621 1997 ProTherm 15343 6976 109 C33S, C36S, L79C Thioredoxin 1 Escherichia coli (strain K12) 3.0 5.14 1.72 yes Tris 50 mM 25.0 Refraction Urea 8.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain Nucleophile, Nucleophile 9.0, 9.0, 7.0 2TRX, 2H6X 19.381666501363117, 17.433333079020183, 11.567499876022339, 39.85333379109701, 39.33500099182129, 26.56375002861023 in tunnel in pocket 8251515 10.1021/bi00210a046 1993 ProTherm 15344 6976 109 C33S, C36S, L79C Thioredoxin 1 Escherichia coli (strain K12) 3.49 5.95 1.71 yes Tris 50 mM 25.0 Refraction Urea 8.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain Nucleophile, Nucleophile 9.0, 9.0, 7.0 2TRX, 2H6X 19.381666501363117, 17.433333079020183, 11.567499876022339, 39.85333379109701, 39.33500099182129, 26.56375002861023 in tunnel in pocket 8251515 10.1021/bi00210a046 1993 ProTherm 10742 4565 109 P35S Thioredoxin 1 Escherichia coli (strain K12) 0.1 8.8 Unknown Potassium phosphate 50 mM 25.0 CD GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 9.0 2TRX, 2H6X 17.88571412222726, 37.53714207240513 3322388 10.1021/bi00395a028 1987 ProTherm SAAFEC_S1262.csv 12550 4565 109 P35S Thioredoxin 1 Escherichia coli (strain K12) 8.5 yes Tris 0.1 M 23.0 KCl 0.2 M Absorbance Urea 8.7 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 9.0 2TRX, 2H6X 17.88571412222726, 37.53714207240513 1961723 10.1073/pnas.88.23.10573 1991 ProTherm 12551 4565 109 P35S Thioredoxin 1 Escherichia coli (strain K12) 9.4 yes Tris 0.1 M 23.0 KCl 0.2 M Absorbance Urea 8.7 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 9.0 2TRX, 2H6X 17.88571412222726, 37.53714207240513 1961723 10.1073/pnas.88.23.10573 1991 ProTherm 464 258 109 C36A Thioredoxin 1 Escherichia coli (strain K12) Unknown 73.0 sodium phosphate 50 mM CD Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain Nucleophile 9.0 2TRX, 2H6X 17.433333079020183, 39.33500099182129 in tunnel in pocket 11513583 10.1021/bi010427y 2001 ProTherm 8759 258 109 C36A Thioredoxin 1 Escherichia coli (strain K12) 1.7 -5.9 3.5 Unknown sodium phosphate 50 mM 25.0 CD GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain Nucleophile 9.0 2TRX, 2H6X 17.433333079020183, 39.33500099182129 in tunnel in pocket 11513583 10.1021/bi010427y 2001 ProTherm 3934 2029 109 M38L Thioredoxin 1 Escherichia coli (strain K12) 2.47 88.6 yes 84.1 phosphate 50 mM DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7.0 2TRX, 2H6X 27.862499475479126, 43.69874954223633 in tunnel 10595549 10.1110/ps.8.11.2455 1999 ProTherm 7112 2029 109 M38L Thioredoxin 1 Escherichia coli (strain K12) 1.4 2.9 2.0 yes phosphate 50 mM 60.0 DSC GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7.0 2TRX, 2H6X 27.862499475479126, 43.69874954223633 in tunnel 10595549 10.1110/ps.8.11.2455 1999 ProTherm 7307 2029 109 M38L Thioredoxin 1 Escherichia coli (strain K12) 2.29 5.3 2.1 yes phosphate 50 mM 55.0 DSC GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7.0 2TRX, 2H6X 27.862499475479126, 43.69874954223633 in tunnel 10595549 10.1110/ps.8.11.2455 1999 ProTherm 7879 2029 109 M38L Thioredoxin 1 Escherichia coli (strain K12) 2.45 7.6 3.1 yes phosphate 50 mM 45.0 DSC GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7.0 2TRX, 2H6X 27.862499475479126, 43.69874954223633 in tunnel 10595549 10.1110/ps.8.11.2455 1999 ProTherm 8149 2029 109 M38L Thioredoxin 1 Escherichia coli (strain K12) 2.74 6.1 2.2 yes phosphate 50 mM 40.0 DSC GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7.0 2TRX, 2H6X 27.862499475479126, 43.69874954223633 in tunnel 10595549 10.1110/ps.8.11.2455 1999 ProTherm 11046 2029 109 M38L Thioredoxin 1 Escherichia coli (strain K12) 2.58 9.1 3.7 yes phosphate 50 mM 25.0 DSC GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7.0 2TRX, 2H6X 27.862499475479126, 43.69874954223633 in tunnel 10595549 10.1110/ps.8.11.2455 1999 ProTherm 13883 2029 109 M38L Thioredoxin 1 Escherichia coli (strain K12) 2.34 8.0 3.4 yes phosphate 50 mM 15.0 DSC GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7.0 2TRX, 2H6X 27.862499475479126, 43.69874954223633 in tunnel 10595549 10.1110/ps.8.11.2455 1999 ProTherm 14088 2029 109 M38L Thioredoxin 1 Escherichia coli (strain K12) 2.47 5.9 2.4 yes phosphate 50 mM 10.0 DSC GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7.0 2TRX, 2H6X 27.862499475479126, 43.69874954223633 in tunnel 10595549 10.1110/ps.8.11.2455 1999 ProTherm 14184 2029 109 M38L Thioredoxin 1 Escherichia coli (strain K12) 2.15 6.2 2.9 yes phosphate 50 mM 8.0 DSC GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7.0 2TRX, 2H6X 27.862499475479126, 43.69874954223633 in tunnel 10595549 10.1110/ps.8.11.2455 1999 ProTherm 14185 2029 109 M38L Thioredoxin 1 Escherichia coli (strain K12) 2.11 8.0 3.9 yes phosphate 50 mM 6.0 DSC GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7.0 2TRX, 2H6X 27.862499475479126, 43.69874954223633 in tunnel 10595549 10.1110/ps.8.11.2455 1999 ProTherm 14328 2029 109 M38L Thioredoxin 1 Escherichia coli (strain K12) 2.09 8.0 3.8 yes phosphate 50 mM 4.0 DSC GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7.0 2TRX, 2H6X 27.862499475479126, 43.69874954223633 in tunnel 10595549 10.1110/ps.8.11.2455 1999 ProTherm 14775 6926 109 M38L, P41S Thioredoxin 1 Escherichia coli (strain K12) 2.45 96.4 yes 83.7 phosphate 50 mM DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7.0, 9.0 2TRX, 2H6X 27.862499475479126, 15.79714298248291, 43.69874954223633, 38.58428519112723 in tunnel 10595549 10.1110/ps.8.11.2455 1999 ProTherm 14918 6926 109 M38L, P41S Thioredoxin 1 Escherichia coli (strain K12) 1.44 2.2 1.5 yes phosphate 50 mM 65.0 DSC GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7.0, 9.0 2TRX, 2H6X 27.862499475479126, 15.79714298248291, 43.69874954223633, 38.58428519112723 in tunnel 10595549 10.1110/ps.8.11.2455 1999 ProTherm 14955 6926 109 M38L, P41S Thioredoxin 1 Escherichia coli (strain K12) 2.1 3.4 1.6 yes phosphate 50 mM 60.0 DSC GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7.0, 9.0 2TRX, 2H6X 27.862499475479126, 15.79714298248291, 43.69874954223633, 38.58428519112723 in tunnel 10595549 10.1110/ps.8.11.2455 1999 ProTherm 14973 6926 109 M38L, P41S Thioredoxin 1 Escherichia coli (strain K12) 2.1 6.6 3.1 yes phosphate 50 mM 55.0 DSC GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7.0, 9.0 2TRX, 2H6X 27.862499475479126, 15.79714298248291, 43.69874954223633, 38.58428519112723 in tunnel 10595549 10.1110/ps.8.11.2455 1999 ProTherm 15051 6926 109 M38L, P41S Thioredoxin 1 Escherichia coli (strain K12) 2.41 5.0 2.1 yes phosphate 50 mM 50.0 DSC GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7.0, 9.0 2TRX, 2H6X 27.862499475479126, 15.79714298248291, 43.69874954223633, 38.58428519112723 in tunnel 10595549 10.1110/ps.8.11.2455 1999 ProTherm 15094 6926 109 M38L, P41S Thioredoxin 1 Escherichia coli (strain K12) 2.53 8.6 3.4 yes phosphate 50 mM 45.0 DSC GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7.0, 9.0 2TRX, 2H6X 27.862499475479126, 15.79714298248291, 43.69874954223633, 38.58428519112723 in tunnel 10595549 10.1110/ps.8.11.2455 1999 ProTherm 15116 6926 109 M38L, P41S Thioredoxin 1 Escherichia coli (strain K12) 2.71 9.4 3.4 yes phosphate 50 mM 40.0 DSC GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7.0, 9.0 2TRX, 2H6X 27.862499475479126, 15.79714298248291, 43.69874954223633, 38.58428519112723 in tunnel 10595549 10.1110/ps.8.11.2455 1999 ProTherm 15129 6926 109 M38L, P41S Thioredoxin 1 Escherichia coli (strain K12) 2.73 8.1 3.0 yes phosphate 50 mM 37.0 DSC GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7.0, 9.0 2TRX, 2H6X 27.862499475479126, 15.79714298248291, 43.69874954223633, 38.58428519112723 in tunnel 10595549 10.1110/ps.8.11.2455 1999 ProTherm 15139 6926 109 M38L, P41S Thioredoxin 1 Escherichia coli (strain K12) 2.84 10.1 3.6 yes phosphate 50 mM 30.0 DSC GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7.0, 9.0 2TRX, 2H6X 27.862499475479126, 15.79714298248291, 43.69874954223633, 38.58428519112723 in tunnel 10595549 10.1110/ps.8.11.2455 1999 ProTherm 15389 6926 109 M38L, P41S Thioredoxin 1 Escherichia coli (strain K12) 2.87 11.5 4.0 yes phosphate 50 mM 25.0 DSC GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7.0, 9.0 2TRX, 2H6X 27.862499475479126, 15.79714298248291, 43.69874954223633, 38.58428519112723 in tunnel 10595549 10.1110/ps.8.11.2455 1999 ProTherm 15598 6926 109 M38L, P41S Thioredoxin 1 Escherichia coli (strain K12) 2.85 10.4 3.6 yes phosphate 50 mM 20.0 DSC GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7.0, 9.0 2TRX, 2H6X 27.862499475479126, 15.79714298248291, 43.69874954223633, 38.58428519112723 in tunnel 10595549 10.1110/ps.8.11.2455 1999 ProTherm 15609 6926 109 M38L, P41S Thioredoxin 1 Escherichia coli (strain K12) 2.76 7.3 2.6 yes phosphate 50 mM 15.0 DSC GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7.0, 9.0 2TRX, 2H6X 27.862499475479126, 15.79714298248291, 43.69874954223633, 38.58428519112723 in tunnel 10595549 10.1110/ps.8.11.2455 1999 ProTherm 15618 6926 109 M38L, P41S Thioredoxin 1 Escherichia coli (strain K12) 2.71 9.2 3.4 yes phosphate 50 mM 10.0 DSC GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7.0, 9.0 2TRX, 2H6X 27.862499475479126, 15.79714298248291, 43.69874954223633, 38.58428519112723 in tunnel 10595549 10.1110/ps.8.11.2455 1999 ProTherm 15627 6926 109 M38L, P41S Thioredoxin 1 Escherichia coli (strain K12) 2.47 8.6 3.5 yes phosphate 50 mM 5.0 DSC GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7.0, 9.0 2TRX, 2H6X 27.862499475479126, 15.79714298248291, 43.69874954223633, 38.58428519112723 in tunnel 10595549 10.1110/ps.8.11.2455 1999 ProTherm 11544 4960 109 I39V Thioredoxin 1 Escherichia coli (strain K12) 4.0 no 2.0 Hepes 5 mM 25.0 fluorescence Urea 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7.0 2TRX, 2H6X 17.637500286102295, 38.84124946594238 in tunnel in pocket 16935299 10.1016/j.jmb.2006.07.065 2006 ProTherm 11545 4961 109 I42V Thioredoxin 1 Escherichia coli (strain K12) 2.7 no 2.0 Hepes 5 mM 25.0 fluorescence Urea 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 5.0 2TRX, 2H6X 15.316250085830688, 37.485000133514404 16935299 10.1016/j.jmb.2006.07.065 2006 ProTherm 11532 4949 109 D44E Thioredoxin 1 Escherichia coli (strain K12) -2.4 no 2.0 Hepes 5 mM 25.0 fluorescence Urea 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 4.0 2TRX, 2H6X 15.619999885559082, 42.85249996185303 in pocket 16935299 10.1016/j.jmb.2006.07.065 2006 ProTherm 11537 4954 109 E45D Thioredoxin 1 Escherichia coli (strain K12) 2.7 no 2.0 Hepes 5 mM 25.0 fluorescence Urea 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 5.0 2TRX, 2H6X 19.02555539872911, 47.20333353678385 16935299 10.1016/j.jmb.2006.07.065 2006 ProTherm 11546 4962 109 I46V Thioredoxin 1 Escherichia coli (strain K12) 6.27 3.3 1.21 no 2.0 Hepes 5 mM 25.0 fluorescence Urea 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 6.0 2TRX, 2H6X 16.597500324249268, 47.5199990272522 16935299 10.1016/j.jmb.2006.07.065 2006 ProTherm 11533 4950 109 D48E Thioredoxin 1 Escherichia coli (strain K12) -1.2 no 2.0 Hepes 5 mM 25.0 fluorescence Urea 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 1.0 2TRX, 2H6X 19.18250036239624, 61.17999982833862 16935299 10.1016/j.jmb.2006.07.065 2006 ProTherm 11538 4955 109 E49D Thioredoxin 1 Escherichia coli (strain K12) 4.5 no 2.0 Hepes 5 mM 25.0 fluorescence Urea 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 5.0 2TRX, 2H6X 22.170000076293945, 58.65000025431315 16935299 10.1016/j.jmb.2006.07.065 2006 ProTherm 11552 4968 109 V56I Thioredoxin 1 Escherichia coli (strain K12) 1.3 no 2.0 Hepes 5 mM 25.0 fluorescence Urea 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7.0 2TRX, 2H6X 12.18285710471017, 32.785714285714285 in pocket 16935299 10.1016/j.jmb.2006.07.065 2006 ProTherm 11547 4963 109 I61V Thioredoxin 1 Escherichia coli (strain K12) 0.8 no 2.0 Hepes 5 mM 25.0 fluorescence Urea 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7.0 2TRX, 2H6X 17.84999990463257, 37.27499961853027 16935299 10.1016/j.jmb.2006.07.065 2006 ProTherm 11534 4951 109 D62E Thioredoxin 1 Escherichia coli (strain K12) 2.6 no 2.0 Hepes 5 mM 25.0 fluorescence Urea 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 9.0 2TRX, 2H6X 21.538749933242798, 38.18625020980835 16935299 10.1016/j.jmb.2006.07.065 2006 ProTherm 465 259 109 T67L Thioredoxin 1 Escherichia coli (strain K12) Unknown 85.0 sodium phosphate 50 mM CD Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 6.0 2TRX, 2H6X 18.792857306344168, 37.812857491629465 11513583 10.1021/bi010427y 2001 ProTherm 8760 259 109 T67L Thioredoxin 1 Escherichia coli (strain K12) 2.4 -7.6 3.1 Unknown sodium phosphate 50 mM 25.0 CD GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 6.0 2TRX, 2H6X 18.792857306344168, 37.812857491629465 11513583 10.1021/bi010427y 2001 ProTherm 11548 4964 109 I73V Thioredoxin 1 Escherichia coli (strain K12) 0.1 no 2.0 Hepes 5 mM 25.0 fluorescence Urea 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 8.0 2TRX, 2H6X 23.573750019073486, 39.684998989105225 16935299 10.1016/j.jmb.2006.07.065 2006 ProTherm 11549 4965 109 I76V Thioredoxin 1 Escherichia coli (strain K12) 3.0 no 2.0 Hepes 5 mM 25.0 fluorescence Urea 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 9.0 2TRX, 2H6X 16.508749842643738, 37.46875 16935299 10.1016/j.jmb.2006.07.065 2006 ProTherm 10741 4564 109 P77A Thioredoxin 1 Escherichia coli (strain K12) 3.9 5.0 Unknown Potassium phosphate 50 mM 25.0 CD GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 9.0 2TRX, 2H6X 14.65999984741211, 32.74428612845285 in tunnel in pocket 3322388 10.1021/bi00395a028 1987 ProTherm SAAFEC_S1262.csv 466 260 109 T78V Thioredoxin 1 Escherichia coli (strain K12) Unknown 82.0 sodium phosphate 50 mM CD Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 9.0 2TRX, 2H6X 11.372857366289411, 31.834286008562362 11513583 10.1021/bi010427y 2001 ProTherm 8761 260 109 T78V Thioredoxin 1 Escherichia coli (strain K12) 2.5 -7.9 3.2 Unknown sodium phosphate 50 mM 25.0 CD GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 9.0 2TRX, 2H6X 11.372857366289411, 31.834286008562362 11513583 10.1021/bi010427y 2001 ProTherm 15910 7486 109 T78C, V92C Thioredoxin 1 Escherichia coli (strain K12) 7.0 yes 96.8 citrate, glycine, HEPES 10 mM, 10mM, 10 mM DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 9.0, 7.0 2TRX, 2H6X 11.372857366289411, 13.738571575709752, 31.834286008562362, 35.09142902919224 16262263 10.1021/bi050921s 2005 ProTherm 15913 7486 109 T78C, V92C Thioredoxin 1 Escherichia coli (strain K12) -0.3 yes 75.0 citrate, glycine, HEPES 10 mM, 10mM, 10 mM DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 9.0, 7.0 2TRX, 2H6X 11.372857366289411, 13.738571575709752, 31.834286008562362, 35.09142902919224 16262263 10.1021/bi050921s 2005 ProTherm 16687 7486 109 T78C, V92C Thioredoxin 1 Escherichia coli (strain K12) -2.1 yes citrate, glycine, HEPES 10 mM, 10mM, 10 mM 89.8 DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 9.0, 7.0 2TRX, 2H6X 11.372857366289411, 13.738571575709752, 31.834286008562362, 35.09142902919224 16262263 10.1021/bi050921s 2005 ProTherm 16962 7486 109 T78C, V92C Thioredoxin 1 Escherichia coli (strain K12) 3.15 -2.1 11.7 3.7 yes phosphate 10 mM 25.0 Fluorescence GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 9.0, 7.0 2TRX, 2H6X 11.372857366289411, 13.738571575709752, 31.834286008562362, 35.09142902919224 16262263 10.1021/bi050921s 2005 ProTherm 16965 7486 109 T78C, V92C Thioredoxin 1 Escherichia coli (strain K12) 1.72 -0.2 6.4 3.6 yes phosphate 10 mM 25.0 Fluorescence GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 9.0, 7.0 2TRX, 2H6X 11.372857366289411, 13.738571575709752, 31.834286008562362, 35.09142902919224 16262263 10.1021/bi050921s 2005 ProTherm 3106 1657 109 L79K Thioredoxin 1 Escherichia coli (strain K12) 0.94 -13.7 yes 71.6 Sodium phosphate 50 mM DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7.0 2TRX, 2H6X 11.567499876022339, 26.56375002861023 7857925 10.1021/bi00007a007 1995 ProTherm M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6478 1657 109 L79K Thioredoxin 1 Escherichia coli (strain K12) 0.94 3.9 yes Sodium phosphate 50 mM 85.32 DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7.0 2TRX, 2H6X 11.567499876022339, 26.56375002861023 7857925 10.1021/bi00007a007 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3107 1658 109 L79R Thioredoxin 1 Escherichia coli (strain K12) 1.09 -16.1 yes 69.2 Sodium phosphate 50 mM DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7.0 2TRX, 2H6X 11.567499876022339, 26.56375002861023 7857925 10.1021/bi00007a007 1995 ProTherm M47andM8_S1810.csv, M47andM8_S2760.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 6479 1658 109 L79R Thioredoxin 1 Escherichia coli (strain K12) 1.09 4.0 yes Sodium phosphate 50 mM 85.32 DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7.0 2TRX, 2H6X 11.567499876022339, 26.56375002861023 7857925 10.1021/bi00007a007 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 15911 7487 109 L79C, K91C Thioredoxin 1 Escherichia coli (strain K12) -7.2 yes 81.6 citrate, glycine, HEPES 10 mM, 10mM, 10 mM DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7.0, 4.0 2TRX, 2H6X 11.567499876022339, 16.039999855889214, 26.56375002861023, 32.55888896518283 16262263 10.1021/bi050921s 2005 ProTherm 15914 7487 109 L79C, K91C Thioredoxin 1 Escherichia coli (strain K12) 0.2 yes 75.5 citrate, glycine, HEPES 10 mM, 10mM, 10 mM DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7.0, 4.0 2TRX, 2H6X 11.567499876022339, 16.039999855889214, 26.56375002861023, 32.55888896518283 16262263 10.1021/bi050921s 2005 ProTherm 16688 7487 109 L79C, K91C Thioredoxin 1 Escherichia coli (strain K12) 2.7 yes citrate, glycine, HEPES 10 mM, 10mM, 10 mM 89.8 DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7.0, 4.0 2TRX, 2H6X 11.567499876022339, 16.039999855889214, 26.56375002861023, 32.55888896518283 16262263 10.1021/bi050921s 2005 ProTherm 16963 7487 109 L79C, K91C Thioredoxin 1 Escherichia coli (strain K12) 1.85 2.9 6.7 3.7 yes phosphate 10 mM 25.0 Fluorescence GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7.0, 4.0 2TRX, 2H6X 11.567499876022339, 16.039999855889214, 26.56375002861023, 32.55888896518283 16262263 10.1021/bi050921s 2005 ProTherm 16966 7487 109 L79C, K91C Thioredoxin 1 Escherichia coli (strain K12) 1.71 -0.1 6.3 3.6 yes phosphate 10 mM 25.0 Fluorescence GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7.0, 4.0 2TRX, 2H6X 11.567499876022339, 16.039999855889214, 26.56375002861023, 32.55888896518283 16262263 10.1021/bi050921s 2005 ProTherm 15912 7488 109 L80C, T90C Thioredoxin 1 Escherichia coli (strain K12) 9.8 yes 99.6 citrate, glycine, HEPES 10 mM, 10mM, 10 mM DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 5.0, 5.0 2TRX, 2H6X 12.223749995231628, 10.627142769949776, 29.90750002861023, 31.231428963797434 16262263 10.1021/bi050921s 2005 ProTherm 15915 7488 109 L80C, T90C Thioredoxin 1 Escherichia coli (strain K12) 0.4 yes 75.7 citrate, glycine, HEPES 10 mM, 10mM, 10 mM DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 5.0, 5.0 2TRX, 2H6X 12.223749995231628, 10.627142769949776, 29.90750002861023, 31.231428963797434 16262263 10.1021/bi050921s 2005 ProTherm 16689 7488 109 L80C, T90C Thioredoxin 1 Escherichia coli (strain K12) -2.7 yes citrate, glycine, HEPES 10 mM, 10mM, 10 mM 89.8 DSC Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 5.0, 5.0 2TRX, 2H6X 12.223749995231628, 10.627142769949776, 29.90750002861023, 31.231428963797434 16262263 10.1021/bi050921s 2005 ProTherm 16964 7488 109 L80C, T90C Thioredoxin 1 Escherichia coli (strain K12) 3.2 -2.2 11.8 3.7 yes phosphate 10 mM 25.0 Fluorescence GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 5.0, 5.0 2TRX, 2H6X 12.223749995231628, 10.627142769949776, 29.90750002861023, 31.231428963797434 16262263 10.1021/bi050921s 2005 ProTherm 16967 7488 109 L80C, T90C Thioredoxin 1 Escherichia coli (strain K12) 1.7 -0.1 6.3 3.6 yes phosphate 10 mM 25.0 Fluorescence GdnHCl 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 5.0, 5.0 2TRX, 2H6X 12.223749995231628, 10.627142769949776, 29.90750002861023, 31.231428963797434 16262263 10.1021/bi050921s 2005 ProTherm 225 113 109 E86R Thioredoxin 1 Escherichia coli (strain K12) yes 90.0 sodium phosphate 10 mM CD Thermal 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 4.0 2TRX, 2H6X 25.217777887980144, 36.51333321465386 11391017 10.1093/protein/14.4.255 2001 ProTherm 11539 4956 109 E86D Thioredoxin 1 Escherichia coli (strain K12) 6.27 3.6 1.33 no 2.0 Hepes 5 mM 25.0 fluorescence Urea 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 4.0 2TRX, 2H6X 25.217777887980144, 36.51333321465386 16935299 10.1016/j.jmb.2006.07.065 2006 ProTherm 11553 4969 109 V87I Thioredoxin 1 Escherichia coli (strain K12) 1.6 no 2.0 Hepes 5 mM 25.0 fluorescence Urea 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 4.0 2TRX, 2H6X 14.854285648890905, 33.89999989100865 16935299 10.1016/j.jmb.2006.07.065 2006 ProTherm 11554 4970 109 V92I Thioredoxin 1 Escherichia coli (strain K12) 0.3 no 2.0 Hepes 5 mM 25.0 fluorescence Urea 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 7.0 2TRX, 2H6X 13.738571575709752, 35.09142902919224 16935299 10.1016/j.jmb.2006.07.065 2006 ProTherm 11540 4957 109 E102D Thioredoxin 1 Escherichia coli (strain K12) -0.5 no 2.0 Hepes 5 mM 25.0 fluorescence Urea 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 1.0 2TRX, 2H6X 23.718888812594944, 41.61500040690104 16935299 10.1016/j.jmb.2006.07.065 2006 ProTherm 11535 4952 109 D105E Thioredoxin 1 Escherichia coli (strain K12) 1.4 no 2.0 Hepes 5 mM 25.0 fluorescence Urea 7.0 P0AA25 IPR005746:Thioredoxin, IPR036249:Thioredoxin-like_sf, IPR017937:Thioredoxin_CS, IPR013766:Thioredoxin_domain 3.0 2TRX, 2H6X 22.163749933242798, 41.78874969482422 16935299 10.1016/j.jmb.2006.07.065 2006 ProTherm 18389 128 281 General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) yes 45.0 Sodium phosphate 50 mM NaCl 150 mM CD Thermal 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 9828010 10.1002/pro.5560071121 1998 ProTherm 19742 128 281 General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) yes(>95%) 56.1 Potassium phosphate 10 mM CD Thermal 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 10903875 10.1006/jmbi.2000.3936 2000 ProTherm 20141 128 281 General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 6.2 yes(>95%) Potassium phosphate 10 mM 60.0 CD Thermal 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 10903875 10.1006/jmbi.2000.3936 2000 ProTherm 21959 128 281 General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 8.35 1.88 Unknown Sodium acetate 20 mM 10.0 CD GdnHCl 5.5 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 10029555 10.1021/bi982209j 1999 ProTherm 21960 128 281 General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 6.5 1.59 Unknown Sodium acetate 20 mM 10.0 CD GdnHCl 5.5 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 10029555 10.1021/bi982209j 1999 ProTherm 21961 128 281 General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 9.0 2.0 Unknown Sodium acetate 20 mM 10.0 CD GdnHCl 5.5 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 10029555 10.1021/bi982209j 1999 ProTherm 21962 128 281 General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 10.4 2.09 Unknown Sodium acetate 20 mM 10.0 CD GdnHCl 5.5 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 10029555 10.1021/bi982209j 1999 ProTherm 21963 128 281 General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 9.2 2.1 Unknown Sodium acetate 20 mM 10.0 CD GdnHCl 5.5 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 10029555 10.1021/bi982209j 1999 ProTherm 21964 128 281 General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 8.4 1.5 Unknown Sodium acetate 20 mM 10.0 CD GdnHCl 5.5 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 10029555 10.1021/bi982209j 1999 ProTherm 21965 128 281 General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 6.07 1.57 Unknown Sodium acetate 20 mM 10.0 CD GdnHCl 5.5 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 10029555 10.1021/bi982209j 1999 ProTherm 21966 128 281 General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 11.45 2.01 Unknown Sodium acetate 20 mM 10.0 CD GdnHCl 5.5 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 10029555 10.1021/bi982209j 1999 ProTherm 21967 128 281 General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 8.76 1.93 Unknown Sodium acetate 20 mM 10.0 CD GdnHCl 5.5 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 10029555 10.1021/bi982209j 1999 ProTherm 21968 128 281 General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 10.37 2.06 Unknown Sodium acetate 20 mM 10.0 CD GdnHCl 5.5 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 10029555 10.1021/bi982209j 1999 ProTherm 21969 128 281 General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 9.22 2.03 Unknown Sodium acetate 20 mM 10.0 CD GdnHCl 5.5 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 10029555 10.1021/bi982209j 1999 ProTherm 22019 128 281 General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 10.24 1.82 yes Sodium phosphate 50 mM 5.0 NaCl 150 mM CD GdnHCl 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 7548036 10.1021/bi00039a042 1995 ProTherm 22093 128 281 General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) yes 55.0 sodium phosphate 10 mM CD Thermal 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 11134036 10.1074/jbc.M010492200 2001 ProTherm 22525 128 281 General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 0.17 17.21 yes 4.0 22.0 sodium phosphate 30 mM NaCl 100 mM DSC Thermal 7.4 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 12206769 10.1016/s0022-2836(02)00699-x 2002 ProTherm 22526 128 281 General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 0.14 17.5 yes 4.0 22.1 sodium phosphate 30 mM NaCl 100 mM DSC Thermal 7.4 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 12206769 10.1016/s0022-2836(02)00699-x 2002 ProTherm 22527 128 281 General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 0.14 17.11 yes 4.0 22.0 sodium phosphate 30 mM NaCl 100 mM DSC Thermal 7.4 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 12206769 10.1016/s0022-2836(02)00699-x 2002 ProTherm 22528 128 281 General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 0.14 17.11 yes 4.0 21.9 sodium phosphate 30 mM NaCl 100 mM DSC Thermal 7.4 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 12206769 10.1016/s0022-2836(02)00699-x 2002 ProTherm 22529 128 281 General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 0.1 17.73 yes 4.0 22.3 sodium phosphate 30 mM NaCl 100 mM DSC Thermal 7.4 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 12206769 10.1016/s0022-2836(02)00699-x 2002 ProTherm 22530 128 281 General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 0.29 28.68 yes 4.0 50.4 sodium phosphate 30 mM NaCl 100 mM DSC Thermal 7.4 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 12206769 10.1016/s0022-2836(02)00699-x 2002 ProTherm 22531 128 281 General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 0.22 26.77 yes 4.0 49.0 sodium phosphate 30 mM NaCl 100 mM DSC Thermal 7.4 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 12206769 10.1016/s0022-2836(02)00699-x 2002 ProTherm 22532 128 281 General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 0.19 25.81 yes 4.0 49.0 sodium phosphate 30 mM NaCl 100 mM DSC Thermal 7.4 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 12206769 10.1016/s0022-2836(02)00699-x 2002 ProTherm 22533 128 281 General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 0.19 24.86 yes 4.0 48.3 sodium phosphate 30 mM NaCl 100 mM DSC Thermal 7.4 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 12206769 10.1016/s0022-2836(02)00699-x 2002 ProTherm 22534 128 281 General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 0.17 24.14 yes 4.0 47.7 sodium phosphate 30 mM NaCl 100 mM DSC Thermal 7.4 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 12206769 10.1016/s0022-2836(02)00699-x 2002 ProTherm 22535 128 281 General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 0.5 59.75 yes 4.0 64.2 sodium phosphate 30 mM NaCl 100 mM DSC Thermal 7.4 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 12206769 10.1016/s0022-2836(02)00699-x 2002 ProTherm 22536 128 281 General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 0.6 60.95 yes 4.0 67.7 sodium phosphate 30 mM NaCl 100 mM DSC Thermal 7.4 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 12206769 10.1016/s0022-2836(02)00699-x 2002 ProTherm 22537 128 281 General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 0.6 61.9 yes 4.0 71.6 sodium phosphate 30 mM NaCl 100 mM DSC Thermal 7.4 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 12206769 10.1016/s0022-2836(02)00699-x 2002 ProTherm 22538 128 281 General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 0.5 62.14 yes 4.0 75.2 sodium phosphate 30 mM NaCl 100 mM DSC Thermal 7.4 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 12206769 10.1016/s0022-2836(02)00699-x 2002 ProTherm 22539 128 281 General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 0.41 62.14 yes 4.0 77.9 sodium phosphate 30 mM NaCl 100 mM DSC Thermal 7.4 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 12206769 10.1016/s0022-2836(02)00699-x 2002 ProTherm 27246 128 281 General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 10.1 0.94 Unknown Sodium phosphate 50mM 15.0 NaCl 150 mM CD Urea 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 15037063 10.1016/j.jmb.2003.12.069 2004 ProTherm 27295 128 281 General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 0.75 2.3 1.0 Unknown sodium phosphate 20 mM 10.0 SUPREX GdnHCl 7.5 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 11910027 10.1110/ps.3820102 2002 ProTherm 27296 128 281 General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 1.14 2.9 1.0 Unknown sodium phosphate 20 mM 10.0 SUPREX GdnHCl 7.5 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 11910027 10.1110/ps.3820102 2002 ProTherm 15736 7358 281 R249V, Y265W General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 0.33 22.47 -3.6 yes 4.0 45.6 sodium phosphate 30 mM NaCl 100 mM DSC Thermal 7.4 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 9.0, 5.0 2ZTA 55.71909089521928, 18.447500228881836, 47.524545582857996, 20.518333911895752 in tunnel in pocket 12206769 10.1016/s0022-2836(02)00699-x 2002 ProTherm 15737 7358 281 R249V, Y265W General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 0.43 21.75 -5.5 yes 4.0 43.5 sodium phosphate 30 mM NaCl 100 mM DSC Thermal 7.4 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 9.0, 5.0 2ZTA 55.71909089521928, 18.447500228881836, 47.524545582857996, 20.518333911895752 in tunnel in pocket 12206769 10.1016/s0022-2836(02)00699-x 2002 ProTherm 15741 7358 281 R249V, Y265W General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 0.69 48.76 -6.1 yes 4.0 65.5 sodium phosphate 30 mM NaCl 100 mM DSC Thermal 7.4 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 9.0, 5.0 2ZTA 55.71909089521928, 18.447500228881836, 47.524545582857996, 20.518333911895752 in tunnel in pocket 12206769 10.1016/s0022-2836(02)00699-x 2002 ProTherm 15742 7358 281 R249V, Y265W General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 0.6 48.28 -6.0 yes 4.0 65.6 sodium phosphate 30 mM NaCl 100 mM DSC Thermal 7.4 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 9.0, 5.0 2ZTA 55.71909089521928, 18.447500228881836, 47.524545582857996, 20.518333911895752 in tunnel in pocket 12206769 10.1016/s0022-2836(02)00699-x 2002 ProTherm 15730 7357 281 M250V, Y265W General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 0.17 15.77 -4.0 yes 4.0 18.0 sodium phosphate 30 mM NaCl 100 mM DSC Thermal 7.4 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 9.0, 5.0 2ZTA 50.581249475479126, 18.447500228881836, 35.12625050544739, 20.518333911895752 in pocket 12206769 10.1016/s0022-2836(02)00699-x 2002 ProTherm 15731 7357 281 M250V, Y265W General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 0.14 15.54 -2.1 yes 4.0 19.9 sodium phosphate 30 mM NaCl 100 mM DSC Thermal 7.4 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 9.0, 5.0 2ZTA 50.581249475479126, 18.447500228881836, 35.12625050544739, 20.518333911895752 in pocket 12206769 10.1016/s0022-2836(02)00699-x 2002 ProTherm 15732 7357 281 M250V, Y265W General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 0.14 15.54 -4.1 yes 4.0 17.9 sodium phosphate 30 mM NaCl 100 mM DSC Thermal 7.4 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 9.0, 5.0 2ZTA 50.581249475479126, 18.447500228881836, 35.12625050544739, 20.518333911895752 in pocket 12206769 10.1016/s0022-2836(02)00699-x 2002 ProTherm 15733 7357 281 M250V, Y265W General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 0.29 26.53 7.5 yes 4.0 56.5 sodium phosphate 30 mM NaCl 100 mM DSC Thermal 7.4 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 9.0, 5.0 2ZTA 50.581249475479126, 18.447500228881836, 35.12625050544739, 20.518333911895752 in pocket 12206769 10.1016/s0022-2836(02)00699-x 2002 ProTherm 15734 7357 281 M250V, Y265W General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 0.24 24.62 7.7 yes 4.0 56.7 sodium phosphate 30 mM NaCl 100 mM DSC Thermal 7.4 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 9.0, 5.0 2ZTA 50.581249475479126, 18.447500228881836, 35.12625050544739, 20.518333911895752 in pocket 12206769 10.1016/s0022-2836(02)00699-x 2002 ProTherm 15735 7357 281 M250V, Y265W General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 0.24 22.23 7.4 yes 4.0 55.7 sodium phosphate 30 mM NaCl 100 mM DSC Thermal 7.4 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 9.0, 5.0 2ZTA 50.581249475479126, 18.447500228881836, 35.12625050544739, 20.518333911895752 in pocket 12206769 10.1016/s0022-2836(02)00699-x 2002 ProTherm 15738 7357 281 M250V, Y265W General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 0.55 54.97 -1.5 yes 4.0 66.2 sodium phosphate 30 mM NaCl 100 mM DSC Thermal 7.4 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 9.0, 5.0 2ZTA 50.581249475479126, 18.447500228881836, 35.12625050544739, 20.518333911895752 in pocket 12206769 10.1016/s0022-2836(02)00699-x 2002 ProTherm 15739 7357 281 M250V, Y265W General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 0.55 55.45 -2.3 yes 4.0 69.3 sodium phosphate 30 mM NaCl 100 mM DSC Thermal 7.4 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 9.0, 5.0 2ZTA 50.581249475479126, 18.447500228881836, 35.12625050544739, 20.518333911895752 in pocket 12206769 10.1016/s0022-2836(02)00699-x 2002 ProTherm 15740 7357 281 M250V, Y265W General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 0.5 54.73 -3.5 yes 4.0 71.7 sodium phosphate 30 mM NaCl 100 mM DSC Thermal 7.4 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 9.0, 5.0 2ZTA 50.581249475479126, 18.447500228881836, 35.12625050544739, 20.518333911895752 in pocket 12206769 10.1016/s0022-2836(02)00699-x 2002 ProTherm 13767 6390 281 K256A General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 0.39 9.71 0.91 Unknown Sodium phosphate 50mM 15.0 NaCl 150 mM CD Urea 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 8.0 2ZTA 26.009999805026585, 21.20444467332628 in tunnel in pocket 15037063 10.1016/j.jmb.2003.12.069 2004 ProTherm 17362 8156 281 K256A, E259Q General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 0.57 9.53 0.94 Unknown Sodium phosphate 50mM 15.0 NaCl 150 mM CD Urea 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 8.0, 4.0 2ZTA 26.009999805026585, 20.68333339691162, 21.20444467332628, 30.705555703904892 in tunnel in pocket 15037063 10.1016/j.jmb.2003.12.069 2004 ProTherm 14827 6965 281 V257I, N264I, V271N, V278I General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) yes(>95%) 79.5 Potassium phosphate 10 mM CD Thermal 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 9.0, 9.0, 9.0, 9.0 2ZTA 14.700000081743513, 18.841249883174896, 33.79285730634417, 52.824286869594026, 11.80000012261527, 22.011250376701355, 28.99142864772252, 54.59428514753069 in tunnel in pocket 10903875 10.1006/jmbi.2000.3936 2000 ProTherm 14957 6965 281 V257I, N264I, V271N, V278I General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 9.9 yes(>95%) Potassium phosphate 10 mM 60.0 CD Thermal 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 9.0, 9.0, 9.0, 9.0 2ZTA 14.700000081743513, 18.841249883174896, 33.79285730634417, 52.824286869594026, 11.80000012261527, 22.011250376701355, 28.99142864772252, 54.59428514753069 in tunnel in pocket 10903875 10.1006/jmbi.2000.3936 2000 ProTherm 14828 6966 281 V257I, V271I, V278I General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) yes(>95%) 69.5 Potassium phosphate 10 mM CD Thermal 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 9.0, 9.0, 9.0 2ZTA 14.700000081743513, 33.79285730634417, 52.824286869594026, 11.80000012261527, 28.99142864772252, 54.59428514753069 in tunnel in pocket 10903875 10.1006/jmbi.2000.3936 2000 ProTherm 14958 6966 281 V257I, V271I, V278I General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 8.1 yes(>95%) Potassium phosphate 10 mM 60.0 CD Thermal 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 9.0, 9.0, 9.0 2ZTA 14.700000081743513, 33.79285730634417, 52.824286869594026, 11.80000012261527, 28.99142864772252, 54.59428514753069 in tunnel in pocket 10903875 10.1006/jmbi.2000.3936 2000 ProTherm 14829 6967 281 V257I, N264I, V271N, V278N General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) yes(>95%) 64.0 Potassium phosphate 10 mM CD Thermal 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 9.0, 9.0, 9.0, 9.0 2ZTA 14.700000081743513, 18.841249883174896, 33.79285730634417, 52.824286869594026, 11.80000012261527, 22.011250376701355, 28.99142864772252, 54.59428514753069 in tunnel in pocket 10903875 10.1006/jmbi.2000.3936 2000 ProTherm 14959 6967 281 V257I, N264I, V271N, V278N General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 7.3 yes(>95%) Potassium phosphate 10 mM 60.0 CD Thermal 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 9.0, 9.0, 9.0, 9.0 2ZTA 14.700000081743513, 18.841249883174896, 33.79285730634417, 52.824286869594026, 11.80000012261527, 22.011250376701355, 28.99142864772252, 54.59428514753069 in tunnel in pocket 10903875 10.1006/jmbi.2000.3936 2000 ProTherm 14830 6968 281 V257I, V271N, V278I General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) yes(>95%) 52.5 Potassium phosphate 10 mM CD Thermal 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 9.0, 9.0, 9.0 2ZTA 14.700000081743513, 33.79285730634417, 52.824286869594026, 11.80000012261527, 28.99142864772252, 54.59428514753069 in tunnel in pocket 10903875 10.1006/jmbi.2000.3936 2000 ProTherm 14960 6968 281 V257I, V271N, V278I General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 5.5 yes(>95%) Potassium phosphate 10 mM 60.0 CD Thermal 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 9.0, 9.0, 9.0 2ZTA 14.700000081743513, 33.79285730634417, 52.824286869594026, 11.80000012261527, 28.99142864772252, 54.59428514753069 in tunnel in pocket 10903875 10.1006/jmbi.2000.3936 2000 ProTherm 14831 6969 281 V257I, V271I, V278N General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) yes(>95%) 50.6 Potassium phosphate 10 mM CD Thermal 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 9.0, 9.0, 9.0 2ZTA 14.700000081743513, 33.79285730634417, 52.824286869594026, 11.80000012261527, 28.99142864772252, 54.59428514753069 in tunnel in pocket 10903875 10.1006/jmbi.2000.3936 2000 ProTherm 14961 6969 281 V257I, V271I, V278N General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 5.3 yes(>95%) Potassium phosphate 10 mM 60.0 CD Thermal 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 9.0, 9.0, 9.0 2ZTA 14.700000081743513, 33.79285730634417, 52.824286869594026, 11.80000012261527, 28.99142864772252, 54.59428514753069 in tunnel in pocket 10903875 10.1006/jmbi.2000.3936 2000 ProTherm 14832 6970 281 V257N, N264I, V271N, V278I General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) yes(>95%) 45.0 Potassium phosphate 10 mM CD Thermal 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 9.0, 9.0, 9.0, 9.0 2ZTA 14.700000081743513, 18.841249883174896, 33.79285730634417, 52.824286869594026, 11.80000012261527, 22.011250376701355, 28.99142864772252, 54.59428514753069 in tunnel in pocket 10903875 10.1006/jmbi.2000.3936 2000 ProTherm 14962 6970 281 V257N, N264I, V271N, V278I General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 5.1 yes(>95%) Potassium phosphate 10 mM 60.0 CD Thermal 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 9.0, 9.0, 9.0, 9.0 2ZTA 14.700000081743513, 18.841249883174896, 33.79285730634417, 52.824286869594026, 11.80000012261527, 22.011250376701355, 28.99142864772252, 54.59428514753069 in tunnel in pocket 10903875 10.1006/jmbi.2000.3936 2000 ProTherm 14833 6971 281 V257N, V271N, V278I General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) yes(>95%) 21.2 Potassium phosphate 10 mM CD Thermal 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 9.0, 9.0, 9.0 2ZTA 14.700000081743513, 33.79285730634417, 52.824286869594026, 11.80000012261527, 28.99142864772252, 54.59428514753069 in tunnel in pocket 10903875 10.1006/jmbi.2000.3936 2000 ProTherm 14963 6971 281 V257N, V271N, V278I General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 0.6 yes(>95%) Potassium phosphate 10 mM 60.0 CD Thermal 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 9.0, 9.0, 9.0 2ZTA 14.700000081743513, 33.79285730634417, 52.824286869594026, 11.80000012261527, 28.99142864772252, 54.59428514753069 in tunnel in pocket 10903875 10.1006/jmbi.2000.3936 2000 ProTherm 226 114 281 E259A General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) yes 51.0 sodium phosphate 10 mM CD Thermal 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 4.0 2ZTA 20.68333339691162, 30.705555703904892 in pocket 11134036 10.1074/jbc.M010492200 2001 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 13768 6391 281 E259Q General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 0.74 9.36 1.02 Unknown Sodium phosphate 50mM 15.0 NaCl 150 mM CD Urea 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 4.0 2ZTA 20.68333339691162, 30.705555703904892 in pocket 15037063 10.1016/j.jmb.2003.12.069 2004 ProTherm 15649 7292 281 E259A, R273A General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) yes 35.0 sodium phosphate 10 mM CD Thermal 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 4.0, 7.0 2ZTA 20.68333339691162, 44.90636374733665, 30.705555703904892, 53.885454351251774 in pocket 11134036 10.1074/jbc.M010492200 2001 ProTherm 17363 8157 281 E259Q, K263A General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 0.14 9.96 0.97 Unknown Sodium phosphate 50mM 15.0 NaCl 150 mM CD Urea 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 4.0, 5.0 2ZTA 20.68333339691162, 27.607778125339085, 30.705555703904892, 27.27333354949951 in pocket 15037063 10.1016/j.jmb.2003.12.069 2004 ProTherm 17367 8161 281 E259Q, E268Q, E270Q General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 2.37 7.73 1.15 Unknown Sodium phosphate 50mM 15.0 NaCl 150 mM CD Urea 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 4.0, 8.0, 9.0 2ZTA 20.68333339691162, 29.9622220993042, 36.47777769300673, 30.705555703904892, 31.333333333333332, 37.72444428337945 in pocket 15037063 10.1016/j.jmb.2003.12.069 2004 ProTherm 14701 6871 281 S262R, H266E, N269R General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 22.0 yes 67.0 Sodium phosphate 50 mM NaCl 150 mM CD Thermal 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 4.0, 4.0, 5.0 2ZTA 23.804999669392902, 25.30099983215332, 21.766249656677246, 20.19333330790202, 30.980999755859376, 42.93125033378601 9828010 10.1002/pro.5560071121 1998 ProTherm 15085 6871 281 S262R, H266E, N269R General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 1.35 -1.72 yes Sodium phosphate 50 mM 45.0 NaCl 150 mM CD Thermal 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 4.0, 4.0, 5.0 2ZTA 23.804999669392902, 25.30099983215332, 21.766249656677246, 20.19333330790202, 30.980999755859376, 42.93125033378601 9828010 10.1002/pro.5560071121 1998 ProTherm 14702 6872 281 S262R, H266E, N269A General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 21.0 yes 67.0 Sodium phosphate 50 mM NaCl 150 mM CD Thermal 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 4.0, 4.0, 5.0 2ZTA 23.804999669392902, 25.30099983215332, 21.766249656677246, 20.19333330790202, 30.980999755859376, 42.93125033378601 9828010 10.1002/pro.5560071121 1998 ProTherm 15086 6872 281 S262R, H266E, N269A General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 1.35 -1.64 yes Sodium phosphate 50 mM 45.0 NaCl 150 mM CD Thermal 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 4.0, 4.0, 5.0 2ZTA 23.804999669392902, 25.30099983215332, 21.766249656677246, 20.19333330790202, 30.980999755859376, 42.93125033378601 9828010 10.1002/pro.5560071121 1998 ProTherm 14703 6873 281 S262A, H266A, N269R General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 16.0 yes 67.0 Sodium phosphate 50 mM NaCl 150 mM CD Thermal 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 4.0, 4.0, 5.0 2ZTA 23.804999669392902, 25.30099983215332, 21.766249656677246, 20.19333330790202, 30.980999755859376, 42.93125033378601 9828010 10.1002/pro.5560071121 1998 ProTherm 15087 6873 281 S262A, H266A, N269R General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 1.35 -1.23 yes Sodium phosphate 50 mM 45.0 NaCl 150 mM CD Thermal 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 4.0, 4.0, 5.0 2ZTA 23.804999669392902, 25.30099983215332, 21.766249656677246, 20.19333330790202, 30.980999755859376, 42.93125033378601 9828010 10.1002/pro.5560071121 1998 ProTherm 14704 6874 281 S262R, H266A, N269R General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 15.0 yes 67.0 Sodium phosphate 50 mM NaCl 150 mM CD Thermal 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 4.0, 4.0, 5.0 2ZTA 23.804999669392902, 25.30099983215332, 21.766249656677246, 20.19333330790202, 30.980999755859376, 42.93125033378601 9828010 10.1002/pro.5560071121 1998 ProTherm 15088 6874 281 S262R, H266A, N269R General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 1.35 -1.15 yes Sodium phosphate 50 mM 45.0 NaCl 150 mM CD Thermal 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 4.0, 4.0, 5.0 2ZTA 23.804999669392902, 25.30099983215332, 21.766249656677246, 20.19333330790202, 30.980999755859376, 42.93125033378601 9828010 10.1002/pro.5560071121 1998 ProTherm 14705 6875 281 S262A, H266E, N269R General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 15.0 yes 67.0 Sodium phosphate 50 mM NaCl 150 mM CD Thermal 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 4.0, 4.0, 5.0 2ZTA 23.804999669392902, 25.30099983215332, 21.766249656677246, 20.19333330790202, 30.980999755859376, 42.93125033378601 9828010 10.1002/pro.5560071121 1998 ProTherm 15089 6875 281 S262A, H266E, N269R General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 1.35 -1.15 yes Sodium phosphate 50 mM 45.0 NaCl 150 mM CD Thermal 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 4.0, 4.0, 5.0 2ZTA 23.804999669392902, 25.30099983215332, 21.766249656677246, 20.19333330790202, 30.980999755859376, 42.93125033378601 9828010 10.1002/pro.5560071121 1998 ProTherm 14706 6876 281 S262R, H266A, N269A General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 14.0 yes 67.0 Sodium phosphate 50 mM NaCl 150 mM CD Thermal 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 4.0, 4.0, 5.0 2ZTA 23.804999669392902, 25.30099983215332, 21.766249656677246, 20.19333330790202, 30.980999755859376, 42.93125033378601 9828010 10.1002/pro.5560071121 1998 ProTherm 15090 6876 281 S262R, H266A, N269A General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 1.35 -1.07 yes Sodium phosphate 50 mM 45.0 NaCl 150 mM CD Thermal 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 4.0, 4.0, 5.0 2ZTA 23.804999669392902, 25.30099983215332, 21.766249656677246, 20.19333330790202, 30.980999755859376, 42.93125033378601 9828010 10.1002/pro.5560071121 1998 ProTherm 14707 6877 281 S262A, H266A, N269A General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 14.0 yes 67.0 Sodium phosphate 50 mM NaCl 150 mM CD Thermal 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 4.0, 4.0, 5.0 2ZTA 23.804999669392902, 25.30099983215332, 21.766249656677246, 20.19333330790202, 30.980999755859376, 42.93125033378601 9828010 10.1002/pro.5560071121 1998 ProTherm 15091 6877 281 S262A, H266A, N269A General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 1.35 -1.07 yes Sodium phosphate 50 mM 45.0 NaCl 150 mM CD Thermal 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 4.0, 4.0, 5.0 2ZTA 23.804999669392902, 25.30099983215332, 21.766249656677246, 20.19333330790202, 30.980999755859376, 42.93125033378601 9828010 10.1002/pro.5560071121 1998 ProTherm 14708 6878 281 S262A, H266E, N269A General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 10.0 yes 67.0 Sodium phosphate 50 mM NaCl 150 mM CD Thermal 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 4.0, 4.0, 5.0 2ZTA 23.804999669392902, 25.30099983215332, 21.766249656677246, 20.19333330790202, 30.980999755859376, 42.93125033378601 9828010 10.1002/pro.5560071121 1998 ProTherm 15092 6878 281 S262A, H266E, N269A General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 1.35 -0.76 yes Sodium phosphate 50 mM 45.0 NaCl 150 mM CD Thermal 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 4.0, 4.0, 5.0 2ZTA 23.804999669392902, 25.30099983215332, 21.766249656677246, 20.19333330790202, 30.980999755859376, 42.93125033378601 9828010 10.1002/pro.5560071121 1998 ProTherm 13769 6392 281 K263A General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 0.41 9.69 0.88 Unknown Sodium phosphate 50mM 15.0 NaCl 150 mM CD Urea 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 5.0 2ZTA 27.607778125339085, 27.27333354949951 15037063 10.1016/j.jmb.2003.12.069 2004 ProTherm 17364 8158 281 K263A, E268Q General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) -0.82 10.92 0.96 Unknown Sodium phosphate 50mM 15.0 NaCl 150 mM CD Urea 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 5.0, 8.0 2ZTA 27.607778125339085, 29.9622220993042, 27.27333354949951, 31.333333333333332 15037063 10.1016/j.jmb.2003.12.069 2004 ProTherm 14709 6879 281 H266R, N269E General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 3.0 yes 67.0 Sodium phosphate 50 mM NaCl 150 mM CD Thermal 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 4.0, 5.0 2ZTA 25.30099983215332, 21.766249656677246, 30.980999755859376, 42.93125033378601 9828010 10.1002/pro.5560071121 1998 ProTherm 15093 6879 281 H266R, N269E General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 1.35 -0.22 yes Sodium phosphate 50 mM 45.0 NaCl 150 mM CD Thermal 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 4.0, 5.0 2ZTA 25.30099983215332, 21.766249656677246, 30.980999755859376, 42.93125033378601 9828010 10.1002/pro.5560071121 1998 ProTherm 13770 6393 281 E268Q General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) -0.2 10.3 0.98 Unknown Sodium phosphate 50mM 15.0 NaCl 150 mM CD Urea 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 8.0 2ZTA 29.9622220993042, 31.333333333333332 15037063 10.1016/j.jmb.2003.12.069 2004 ProTherm 17366 8160 281 E268Q, E270Q General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 1.72 8.38 1.06 Unknown Sodium phosphate 50mM 15.0 NaCl 150 mM CD Urea 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 8.0, 9.0 2ZTA 29.9622220993042, 36.47777769300673, 31.333333333333332, 37.72444428337945 15037063 10.1016/j.jmb.2003.12.069 2004 ProTherm 13771 6394 281 E270Q General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 1.83 8.27 1.03 Unknown Sodium phosphate 50mM 15.0 NaCl 150 mM CD Urea 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 9.0 2ZTA 36.47777769300673, 37.72444428337945 15037063 10.1016/j.jmb.2003.12.069 2004 ProTherm 17365 8159 281 E270Q, K275A General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 2.8 7.3 0.98 Unknown Sodium phosphate 50mM 15.0 NaCl 150 mM CD Urea 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 9.0, 6.0 2ZTA 36.47777769300673, 51.408888287014435, 37.72444428337945, 48.59111192491319 15037063 10.1016/j.jmb.2003.12.069 2004 ProTherm 227 115 281 R273A General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) yes 37.0 sodium phosphate 10 mM CD Thermal 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 7.0 2ZTA 44.90636374733665, 53.885454351251774 11134036 10.1074/jbc.M010492200 2001 ProTherm 13772 115 281 R273A General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 1.66 8.44 0.98 Unknown Sodium phosphate 50mM 15.0 NaCl 150 mM CD Urea 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 7.0 2ZTA 44.90636374733665, 53.885454351251774 15037063 10.1016/j.jmb.2003.12.069 2004 ProTherm 13773 6395 281 K275A General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 0.91 9.19 0.96 Unknown Sodium phosphate 50mM 15.0 NaCl 150 mM CD Urea 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 6.0 2ZTA 51.408888287014435, 48.59111192491319 15037063 10.1016/j.jmb.2003.12.069 2004 ProTherm 13774 6396 281 K276A General control transcription factor GCN4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 0.06 10.04 0.88 Unknown Sodium phosphate 50mM 15.0 NaCl 150 mM CD Urea 7.0 P03069 IPR050946:AP-1_TF_bZIP, IPR004827:bZIP, IPR046347:bZIP_sf 6.0 2ZTA 58.50555504692925, 57.51111051771376 15037063 10.1016/j.jmb.2003.12.069 2004 ProTherm 22106 131 211 Growth factor receptor-bound protein 2 Drosophila melanogaster Unknown 63.7 phosphate 50 mM Na2SO4 0.4 M CD Thermal 6.0 Q08012 IPR043539:Grb2-like, IPR000980:SH2, IPR036860:SH2_dom_sf, IPR036028:SH3-like_dom_sf, IPR001452:SH3_domain 11273710 10.1006/jmbi.2001.4521 2001 ProTherm 22541 131 211 Growth factor receptor-bound protein 2 Drosophila melanogaster 16.1 yes 35.7 sodium phosphate 50 mM CD Thermal 6.0 Q08012 IPR043539:Grb2-like, IPR000980:SH2, IPR036860:SH2_dom_sf, IPR036028:SH3-like_dom_sf, IPR001452:SH3_domain 12215422 10.1016/s0022-2836(02)00741-6 2002 ProTherm 22542 131 211 Growth factor receptor-bound protein 2 Drosophila melanogaster 33.1 yes 60.1 sodium phosphate 50 mM Na2SO4 0.4 M CD Thermal 6.0 Q08012 IPR043539:Grb2-like, IPR000980:SH2, IPR036860:SH2_dom_sf, IPR036028:SH3-like_dom_sf, IPR001452:SH3_domain 12215422 10.1016/s0022-2836(02)00741-6 2002 ProTherm 25544 131 211 Growth factor receptor-bound protein 2 Drosophila melanogaster 1.8 Unknown phosphate 50 mM 25.0 Na2SO4 0.4 M CD Thermal 6.0 Q08012 IPR043539:Grb2-like, IPR000980:SH2, IPR036860:SH2_dom_sf, IPR036028:SH3-like_dom_sf, IPR001452:SH3_domain 11273710 10.1006/jmbi.2001.4521 2001 ProTherm 27348 131 211 Growth factor receptor-bound protein 2 Drosophila melanogaster 2.18 1.39 yes sodium phosphate 50 mM 5.0 Na2SO4 0.4 M Fluorescence GdnHCl 6.0 Q08012 IPR043539:Grb2-like, IPR000980:SH2, IPR036860:SH2_dom_sf, IPR036028:SH3-like_dom_sf, IPR001452:SH3_domain 12215422 10.1016/s0022-2836(02)00741-6 2002 ProTherm 27349 131 211 Growth factor receptor-bound protein 2 Drosophila melanogaster 1.47 3.48 yes sodium phosphate 50 mM 5.0 CD GdnHCl 6.0 Q08012 IPR043539:Grb2-like, IPR000980:SH2, IPR036860:SH2_dom_sf, IPR036028:SH3-like_dom_sf, IPR001452:SH3_domain 12215422 10.1016/s0022-2836(02)00741-6 2002 ProTherm 228 116 211 T22G Growth factor receptor-bound protein 2 Drosophila melanogaster 21.1 Unknown 84.8 phosphate 50 mM Na2SO4 0.4 M CD Thermal 6.0 Q08012 IPR043539:Grb2-like, IPR000980:SH2, IPR036860:SH2_dom_sf, IPR036028:SH3-like_dom_sf, IPR001452:SH3_domain 5.0 2A36 11273710 10.1006/jmbi.2001.4521 2001 ProTherm 8606 116 211 T22G Growth factor receptor-bound protein 2 Drosophila melanogaster 4.2 Unknown phosphate 50 mM 25.0 Na2SO4 0.4 M CD Thermal 6.0 Q08012 IPR043539:Grb2-like, IPR000980:SH2, IPR036860:SH2_dom_sf, IPR036028:SH3-like_dom_sf, IPR001452:SH3_domain 5.0 2A36 11273710 10.1006/jmbi.2001.4521 2001 ProTherm 12997 116 211 T22G Growth factor receptor-bound protein 2 Drosophila melanogaster -3.6 4.0 2.2 Unknown phosphate 50 mM 20.0 Fluorescence GdnHCl 6.0 Q08012 IPR043539:Grb2-like, IPR000980:SH2, IPR036860:SH2_dom_sf, IPR036028:SH3-like_dom_sf, IPR001452:SH3_domain 5.0 2A36 16274219 10.1021/bi050640k 2005 ProTherm 229 117 211 T22D Growth factor receptor-bound protein 2 Drosophila melanogaster 9.4 Unknown 73.1 phosphate 50 mM Na2SO4 0.4 M CD Thermal 6.0 Q08012 IPR043539:Grb2-like, IPR000980:SH2, IPR036860:SH2_dom_sf, IPR036028:SH3-like_dom_sf, IPR001452:SH3_domain 5.0 2A36 11273710 10.1006/jmbi.2001.4521 2001 ProTherm 8607 117 211 T22D Growth factor receptor-bound protein 2 Drosophila melanogaster 3.3 Unknown phosphate 50 mM 25.0 Na2SO4 0.4 M CD Thermal 6.0 Q08012 IPR043539:Grb2-like, IPR000980:SH2, IPR036860:SH2_dom_sf, IPR036028:SH3-like_dom_sf, IPR001452:SH3_domain 5.0 2A36 11273710 10.1006/jmbi.2001.4521 2001 ProTherm 230 118 211 T22N Growth factor receptor-bound protein 2 Drosophila melanogaster 11.2 Unknown 74.9 phosphate 50 mM Na2SO4 0.4 M CD Thermal 6.0 Q08012 IPR043539:Grb2-like, IPR000980:SH2, IPR036860:SH2_dom_sf, IPR036028:SH3-like_dom_sf, IPR001452:SH3_domain 5.0 2A36 11273710 10.1006/jmbi.2001.4521 2001 ProTherm 8608 118 211 T22N Growth factor receptor-bound protein 2 Drosophila melanogaster 3.1 Unknown phosphate 50 mM 25.0 Na2SO4 0.4 M CD Thermal 6.0 Q08012 IPR043539:Grb2-like, IPR000980:SH2, IPR036860:SH2_dom_sf, IPR036028:SH3-like_dom_sf, IPR001452:SH3_domain 5.0 2A36 11273710 10.1006/jmbi.2001.4521 2001 ProTherm 231 119 211 T22F Growth factor receptor-bound protein 2 Drosophila melanogaster 3.0 Unknown 66.7 phosphate 50 mM Na2SO4 0.4 M CD Thermal 6.0 Q08012 IPR043539:Grb2-like, IPR000980:SH2, IPR036860:SH2_dom_sf, IPR036028:SH3-like_dom_sf, IPR001452:SH3_domain 5.0 2A36 11273710 10.1006/jmbi.2001.4521 2001 ProTherm 8609 119 211 T22F Growth factor receptor-bound protein 2 Drosophila melanogaster 3.1 Unknown phosphate 50 mM 25.0 Na2SO4 0.4 M CD Thermal 6.0 Q08012 IPR043539:Grb2-like, IPR000980:SH2, IPR036860:SH2_dom_sf, IPR036028:SH3-like_dom_sf, IPR001452:SH3_domain 5.0 2A36 11273710 10.1006/jmbi.2001.4521 2001 ProTherm 232 120 211 T22S Growth factor receptor-bound protein 2 Drosophila melanogaster -0.2 Unknown 63.5 phosphate 50 mM Na2SO4 0.4 M CD Thermal 6.0 Q08012 IPR043539:Grb2-like, IPR000980:SH2, IPR036860:SH2_dom_sf, IPR036028:SH3-like_dom_sf, IPR001452:SH3_domain 5.0 2A36 11273710 10.1006/jmbi.2001.4521 2001 ProTherm 8610 120 211 T22S Growth factor receptor-bound protein 2 Drosophila melanogaster 2.4 Unknown phosphate 50 mM 25.0 Na2SO4 0.4 M CD Thermal 6.0 Q08012 IPR043539:Grb2-like, IPR000980:SH2, IPR036860:SH2_dom_sf, IPR036028:SH3-like_dom_sf, IPR001452:SH3_domain 5.0 2A36 11273710 10.1006/jmbi.2001.4521 2001 ProTherm 233 121 211 T22A Growth factor receptor-bound protein 2 Drosophila melanogaster 3.2 Unknown 66.9 phosphate 50 mM Na2SO4 0.4 M CD Thermal 6.0 Q08012 IPR043539:Grb2-like, IPR000980:SH2, IPR036860:SH2_dom_sf, IPR036028:SH3-like_dom_sf, IPR001452:SH3_domain 5.0 2A36 11273710 10.1006/jmbi.2001.4521 2001 ProTherm 8611 121 211 T22A Growth factor receptor-bound protein 2 Drosophila melanogaster 2.2 Unknown phosphate 50 mM 25.0 Na2SO4 0.4 M CD Thermal 6.0 Q08012 IPR043539:Grb2-like, IPR000980:SH2, IPR036860:SH2_dom_sf, IPR036028:SH3-like_dom_sf, IPR001452:SH3_domain 5.0 2A36 11273710 10.1006/jmbi.2001.4521 2001 ProTherm 234 122 211 T22L Growth factor receptor-bound protein 2 Drosophila melanogaster -5.7 Unknown 58.0 phosphate 50 mM Na2SO4 0.4 M CD Thermal 6.0 Q08012 IPR043539:Grb2-like, IPR000980:SH2, IPR036860:SH2_dom_sf, IPR036028:SH3-like_dom_sf, IPR001452:SH3_domain 5.0 2A36 11273710 10.1006/jmbi.2001.4521 2001 ProTherm 8612 122 211 T22L Growth factor receptor-bound protein 2 Drosophila melanogaster 2.3 Unknown phosphate 50 mM 25.0 Na2SO4 0.4 M CD Thermal 6.0 Q08012 IPR043539:Grb2-like, IPR000980:SH2, IPR036860:SH2_dom_sf, IPR036028:SH3-like_dom_sf, IPR001452:SH3_domain 5.0 2A36 11273710 10.1006/jmbi.2001.4521 2001 ProTherm 235 123 211 T22K Growth factor receptor-bound protein 2 Drosophila melanogaster 1.3 Unknown 65.0 phosphate 50 mM Na2SO4 0.4 M CD Thermal 6.0 Q08012 IPR043539:Grb2-like, IPR000980:SH2, IPR036860:SH2_dom_sf, IPR036028:SH3-like_dom_sf, IPR001452:SH3_domain 5.0 2A36 11273710 10.1006/jmbi.2001.4521 2001 ProTherm 8613 123 211 T22K Growth factor receptor-bound protein 2 Drosophila melanogaster 1.8 Unknown phosphate 50 mM 25.0 Na2SO4 0.4 M CD Thermal 6.0 Q08012 IPR043539:Grb2-like, IPR000980:SH2, IPR036860:SH2_dom_sf, IPR036028:SH3-like_dom_sf, IPR001452:SH3_domain 5.0 2A36 11273710 10.1006/jmbi.2001.4521 2001 ProTherm 15650 7293 211 T22G, Q23D Growth factor receptor-bound protein 2 Drosophila melanogaster 25.2 Unknown 88.9 phosphate 50 mM Na2SO4 0.4 M CD Thermal 6.0 Q08012 IPR043539:Grb2-like, IPR000980:SH2, IPR036860:SH2_dom_sf, IPR036028:SH3-like_dom_sf, IPR001452:SH3_domain 5.0, 5.0 2A36 in pocket 11273710 10.1006/jmbi.2001.4521 2001 ProTherm 19735 142 155 Fibroblast growth factor 1 Homo sapiens 61.5 yes 39.45 GuHCl/ADA 0.7 M DSC Thermal 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 10852713 10.1021/bi9927742 2000 ProTherm 19736 142 155 Fibroblast growth factor 1 Homo sapiens yes 25.0 GuHCl/ADA 0.7 M DSC Thermal 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 10852713 10.1021/bi9927742 2000 ProTherm 21314 142 155 Fibroblast growth factor 1 Homo sapiens 4.97 yes GuHCl/ADA 0.7 M 25.0 DSC GdnHCl 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 10852713 10.1021/bi9927742 2000 ProTherm 22108 142 155 Fibroblast growth factor 1 Homo sapiens 62.38 56.14 yes 40.05 N-(2-acetamido)iminodiacetic acid(ADA) 20 mM NaCl 100 mM DSC Thermal 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 11266617 10.1110/ps.37401 2001 ProTherm 22995 142 155 Fibroblast growth factor 1 Homo sapiens 66.2 Yes 39.8 H3PO4 25 mM Fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 15469994 10.1093/protein/gzh076 2004 ProTherm 22996 142 155 Fibroblast growth factor 1 Homo sapiens 67.7 Yes 40.7 H3PO4 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 15469994 10.1093/protein/gzh076 2004 ProTherm 23861 142 155 Fibroblast growth factor 1 Homo sapiens 65.73 Yes (>80%) 39.75 ADA (N-(2-acetamide)iminodiaceticacid) DSC Thermal 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 19695265 10.1016/j.jmb.2009.08.026 2009 ProTherm 24258 142 155 Fibroblast growth factor 1 Homo sapiens 64.9 yes 2.0 40.3 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 19574212 10.1074/jbc.M109.001289 2009 ProTherm 24259 142 155 Fibroblast growth factor 1 Homo sapiens 66.2 yes 2.0 39.8 sodium phosphate 25 mM fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 19574212 10.1074/jbc.M109.001289 2009 ProTherm 24260 142 155 Fibroblast growth factor 1 Homo sapiens 67.7 yes 2.0 40.7 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 19574212 10.1074/jbc.M109.001289 2009 ProTherm 24261 142 155 Fibroblast growth factor 1 Homo sapiens 67.6 yes 2.0 54.1 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 19574212 10.1074/jbc.M109.001289 2009 ProTherm 25933 142 155 Fibroblast growth factor 1 Homo sapiens 1.11 5.04 4.52 yes N-(2-acetamido)-iminodiacetic acid 20 mM 25.0 NaCl 100 mM Fluorescence GdnHCl 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 12729767 10.1016/s0022-2836(03)00321-8 2003 ProTherm 25959 142 155 Fibroblast growth factor 1 Homo sapiens 0.9 4.5 4.7 Unknown Phosphate 100 mM 25.0 Fluorescence GdnHCl 7.2 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 12829501 10.1016/S0006-3495(03)74491-9 2003 ProTherm 25960 142 155 Fibroblast growth factor 1 Homo sapiens 1.8 6.5 3.6 Unknown Phosphate 100 mM 25.0 CD GdnHCl 7.2 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 12829501 10.1016/S0006-3495(03)74491-9 2003 ProTherm 26659 142 155 Fibroblast growth factor 1 Homo sapiens 1.23 6.11 4.97 yes 2.0 Sodium phosphate 50mM 25.0 Fluorescence GdnHCl 8.0 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 25312595 10.1002/jps.24188 2015 ProTherm 26925 142 155 Fibroblast growth factor 1 Homo sapiens 1.13 5.53 4.87 Yes H3PO4 25 mM 20.15 Fluorescence GdnHCl 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 15469994 10.1093/protein/gzh076 2004 ProTherm 17109 7982 155 K27V, C132V, P149V Fibroblast growth factor 1 Homo sapiens 2.18 -3.42 9.53 4.37 yes 2.0 Sodium phosphate 50mM 25.0 Fluorescence GdnHCl 8.0 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0, 4.0, 9.0 2AFG, 1JQZ 47.90444458855523, 32.451666514078774, 19.292857306344168, 27.575555589463974, 14.473333517710367, 18.265714236668178 in pocket 25312596 10.1007/s10858-014-9866-7 2014 ProTherm 11126 4717 155 C31S Fibroblast growth factor 1 Homo sapiens 2.89 2.08 yes GuHCl/ADA 0.7 M 25.0 DSC GdnHCl 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0 2AFG, 1JQZ 20.950000127156574, 16.779999891916912 10852713 10.1021/bi9927742 2000 ProTherm 12477 4717 155 C31S Fibroblast growth factor 1 Homo sapiens 1.68 -1.22 7.33 4.37 yes 2.0 Sodium phosphate 50mM 25.0 Fluorescence GdnHCl 8.0 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0 2AFG, 1JQZ 20.950000127156574, 16.779999891916912 25312598 10.1016/j.jdiacomp.2014.09.004 2015 ProTherm 12476 5774 155 C31A Fibroblast growth factor 1 Homo sapiens 1.57 -0.7 6.81 4.35 yes 2.0 Sodium phosphate 50mM 25.0 Fluorescence GdnHCl 8.0 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0 2AFG, 1JQZ 20.950000127156574, 16.779999891916912 25312597 10.1021/ol5026876 2014 ProTherm 12478 5775 155 C31T Fibroblast growth factor 1 Homo sapiens 1.45 -0.6 6.71 4.63 yes 2.0 Sodium phosphate 50mM 25.0 Fluorescence GdnHCl 8.0 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0 2AFG, 1JQZ 20.950000127156574, 16.779999891916912 25312599 10.1016/j.jdiacomp.2014.09.011 2015 ProTherm 12479 5776 155 C31V Fibroblast growth factor 1 Homo sapiens 1.42 0.74 5.37 3.77 yes 2.0 Sodium phosphate 50mM 25.0 Fluorescence GdnHCl 8.0 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0 2AFG, 1JQZ 20.950000127156574, 16.779999891916912 25312600 10.1016/j.brs.2014.09.009 2015 ProTherm 14819 6957 155 C31S, H108G Fibroblast growth factor 1 Homo sapiens 40.61 -6.4 yes 33.05 GuHCl/ADA 0.7 M DSC Thermal 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0, 6.0 2AFG, 1JQZ 20.950000127156574, 29.013000297546387, 16.779999891916912, 11.58700008392334 10852713 10.1021/bi9927742 2000 ProTherm 15117 6957 155 C31S, H108G Fibroblast growth factor 1 Homo sapiens 0.84 yes N-(2-acetamido)iminodiacetic acid (ADA) 20 mM 39.6 NaCl 0.1 M DSC Thermal 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0, 6.0 2AFG, 1JQZ 20.950000127156574, 29.013000297546387, 16.779999891916912, 11.58700008392334 10852713 10.1021/bi9927742 2000 ProTherm 15410 6957 155 C31S, H108G Fibroblast growth factor 1 Homo sapiens 0.93 4.02 yes GuHCl/ADA 0.7 M 25.0 DSC GdnHCl 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0, 6.0 2AFG, 1JQZ 20.950000127156574, 29.013000297546387, 16.779999891916912, 11.58700008392334 10852713 10.1021/bi9927742 2000 ProTherm 15412 6957 155 C31S, H108G Fibroblast growth factor 1 Homo sapiens 1.39 yes GuHCl/ADA 0.7 M 25.0 DSC Thermal 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0, 6.0 2AFG, 1JQZ 20.950000127156574, 29.013000297546387, 16.779999891916912, 11.58700008392334 10852713 10.1021/bi9927742 2000 ProTherm 1701 942 155 H36Y Fibroblast growth factor 1 Homo sapiens 69.3 3.6 Yes 43.4 H3PO4 25 mM Fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 5.0 2AFG, 1JQZ 25.601999855041505, 16.641999912261962 15469994 10.1093/protein/gzh076 2004 ProTherm 1706 942 155 H36Y Fibroblast growth factor 1 Homo sapiens 67.2 1.8 Yes 42.5 H3PO4 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 5.0 2AFG, 1JQZ 25.601999855041505, 16.641999912261962 15469994 10.1093/protein/gzh076 2004 ProTherm 8073 942 155 H36Y Fibroblast growth factor 1 Homo sapiens -0.39 Yes H3PO4 25 mM 40.7 CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 5.0 2AFG, 1JQZ 25.601999855041505, 16.641999912261962 15469994 10.1093/protein/gzh076 2004 ProTherm khan_protherm_data_mapped.csv 8150 942 155 H36Y Fibroblast growth factor 1 Homo sapiens -0.75 Yes H3PO4 25 mM 39.8 Fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 5.0 2AFG, 1JQZ 25.601999855041505, 16.641999912261962 15469994 10.1093/protein/gzh076 2004 ProTherm 12705 942 155 H36Y Fibroblast growth factor 1 Homo sapiens 1.36 -1.01 6.54 4.8 Yes H3PO4 25 mM 20.15 Fluorescence GdnHCl 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 5.0 2AFG, 1JQZ 25.601999855041505, 16.641999912261962 15469994 10.1093/protein/gzh076 2004 ProTherm 15816 7417 155 H36Y, L59F Fibroblast growth factor 1 Homo sapiens 79.6 5.2 Yes 45.0 H3PO4 25 mM Fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 5.0, 7.0 2AFG, 1JQZ 25.601999855041505, 18.25375008583069, 16.641999912261962, 16.321250081062317 in pocket 15469994 10.1093/protein/gzh076 2004 ProTherm 15827 7417 155 H36Y, L59F Fibroblast growth factor 1 Homo sapiens 64.3 4.2 Yes 44.9 H3PO4 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 5.0, 7.0 2AFG, 1JQZ 25.601999855041505, 18.25375008583069, 16.641999912261962, 16.321250081062317 in pocket 15469994 10.1093/protein/gzh076 2004 ProTherm 16798 7417 155 H36Y, L59F Fibroblast growth factor 1 Homo sapiens -0.89 Yes H3PO4 25 mM 40.7 CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 5.0, 7.0 2AFG, 1JQZ 25.601999855041505, 18.25375008583069, 16.641999912261962, 16.321250081062317 in pocket 15469994 10.1093/protein/gzh076 2004 ProTherm 16811 7417 155 H36Y, L59F Fibroblast growth factor 1 Homo sapiens -1.09 Yes H3PO4 25 mM 39.8 Fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 5.0, 7.0 2AFG, 1JQZ 25.601999855041505, 18.25375008583069, 16.641999912261962, 16.321250081062317 in pocket 15469994 10.1093/protein/gzh076 2004 ProTherm 15817 7418 155 H36Y, H117Y Fibroblast growth factor 1 Homo sapiens 75.9 5.0 Yes 44.8 H3PO4 25 mM Fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 5.0, 6.0 2AFG, 1JQZ 25.601999855041505, 28.4060001373291, 16.641999912261962, 14.86200008392334 15469994 10.1093/protein/gzh076 2004 ProTherm 15828 7418 155 H36Y, H117Y Fibroblast growth factor 1 Homo sapiens 60.2 2.0 Yes 42.7 H3PO4 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 5.0, 6.0 2AFG, 1JQZ 25.601999855041505, 28.4060001373291, 16.641999912261962, 14.86200008392334 15469994 10.1093/protein/gzh076 2004 ProTherm 16812 7418 155 H36Y, H117Y Fibroblast growth factor 1 Homo sapiens -1.05 Yes H3PO4 25 mM 39.8 Fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 5.0, 6.0 2AFG, 1JQZ 25.601999855041505, 28.4060001373291, 16.641999912261962, 14.86200008392334 15469994 10.1093/protein/gzh076 2004 ProTherm 16822 7418 155 H36Y, H117Y Fibroblast growth factor 1 Homo sapiens -0.42 Yes H3PO4 25 mM 39.8 CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 5.0, 6.0 2AFG, 1JQZ 25.601999855041505, 28.4060001373291, 16.641999912261962, 14.86200008392334 15469994 10.1093/protein/gzh076 2004 ProTherm 15818 7419 155 H36Y, F123Y Fibroblast growth factor 1 Homo sapiens 82.2 3.9 Yes 43.7 H3PO4 25 mM Fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 5.0, 6.0 2AFG, 1JQZ 25.601999855041505, 19.290908986871894, 16.641999912261962, 11.326363650235264 15469994 10.1093/protein/gzh076 2004 ProTherm 15829 7419 155 H36Y, F123Y Fibroblast growth factor 1 Homo sapiens 66.8 2.9 Yes 43.6 H3PO4 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 5.0, 6.0 2AFG, 1JQZ 25.601999855041505, 19.290908986871894, 16.641999912261962, 11.326363650235264 15469994 10.1093/protein/gzh076 2004 ProTherm 16799 7419 155 H36Y, F123Y Fibroblast growth factor 1 Homo sapiens -0.61 Yes H3PO4 25 mM 40.7 CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 5.0, 6.0 2AFG, 1JQZ 25.601999855041505, 19.290908986871894, 16.641999912261962, 11.326363650235264 15469994 10.1093/protein/gzh076 2004 ProTherm 16813 7419 155 H36Y, F123Y Fibroblast growth factor 1 Homo sapiens -0.82 Yes H3PO4 25 mM 39.8 Fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 5.0, 6.0 2AFG, 1JQZ 25.601999855041505, 19.290908986871894, 16.641999912261962, 11.326363650235264 15469994 10.1093/protein/gzh076 2004 ProTherm 15822 7423 155 H36Y, L59F, H117Y Fibroblast growth factor 1 Homo sapiens 88.4 6.7 Yes 46.5 H3PO4 25 mM Fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 5.0, 7.0, 6.0 2AFG, 1JQZ 25.601999855041505, 18.25375008583069, 28.4060001373291, 16.641999912261962, 16.321250081062317, 14.86200008392334 in pocket 15469994 10.1093/protein/gzh076 2004 ProTherm 15833 7423 155 H36Y, L59F, H117Y Fibroblast growth factor 1 Homo sapiens 64.0 4.6 Yes 45.3 H3PO4 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 5.0, 7.0, 6.0 2AFG, 1JQZ 25.601999855041505, 18.25375008583069, 28.4060001373291, 16.641999912261962, 16.321250081062317, 14.86200008392334 in pocket 15469994 10.1093/protein/gzh076 2004 ProTherm 16803 7423 155 H36Y, L59F, H117Y Fibroblast growth factor 1 Homo sapiens -0.98 Yes H3PO4 25 mM 40.7 CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 5.0, 7.0, 6.0 2AFG, 1JQZ 25.601999855041505, 18.25375008583069, 28.4060001373291, 16.641999912261962, 16.321250081062317, 14.86200008392334 in pocket 15469994 10.1093/protein/gzh076 2004 ProTherm 16817 7423 155 H36Y, L59F, H117Y Fibroblast growth factor 1 Homo sapiens -1.41 Yes H3PO4 25 mM 39.8 Fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 5.0, 7.0, 6.0 2AFG, 1JQZ 25.601999855041505, 18.25375008583069, 28.4060001373291, 16.641999912261962, 16.321250081062317, 14.86200008392334 in pocket 15469994 10.1093/protein/gzh076 2004 ProTherm 15823 7424 155 H36Y, L59F, F123Y Fibroblast growth factor 1 Homo sapiens 76.1 6.0 Yes 45.8 H3PO4 25 mM Fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 5.0, 7.0, 6.0 2AFG, 1JQZ 25.601999855041505, 18.25375008583069, 19.290908986871894, 16.641999912261962, 16.321250081062317, 11.326363650235264 in pocket 15469994 10.1093/protein/gzh076 2004 ProTherm 15834 7424 155 H36Y, L59F, F123Y Fibroblast growth factor 1 Homo sapiens 67.5 5.4 Yes 46.1 H3PO4 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 5.0, 7.0, 6.0 2AFG, 1JQZ 25.601999855041505, 18.25375008583069, 19.290908986871894, 16.641999912261962, 16.321250081062317, 11.326363650235264 in pocket 15469994 10.1093/protein/gzh076 2004 ProTherm 16804 7424 155 H36Y, L59F, F123Y Fibroblast growth factor 1 Homo sapiens -1.15 Yes H3PO4 25 mM 40.7 CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 5.0, 7.0, 6.0 2AFG, 1JQZ 25.601999855041505, 18.25375008583069, 19.290908986871894, 16.641999912261962, 16.321250081062317, 11.326363650235264 in pocket 15469994 10.1093/protein/gzh076 2004 ProTherm 16818 7424 155 H36Y, L59F, F123Y Fibroblast growth factor 1 Homo sapiens -1.27 Yes H3PO4 25 mM 39.8 Fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 5.0, 7.0, 6.0 2AFG, 1JQZ 25.601999855041505, 18.25375008583069, 19.290908986871894, 16.641999912261962, 16.321250081062317, 11.326363650235264 in pocket 15469994 10.1093/protein/gzh076 2004 ProTherm 15824 7425 155 H36Y, H117Y, F123Y Fibroblast growth factor 1 Homo sapiens 82.4 6.5 Yes 46.3 H3PO4 25 mM Fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 5.0, 6.0, 6.0 2AFG, 1JQZ 25.601999855041505, 28.4060001373291, 19.290908986871894, 16.641999912261962, 14.86200008392334, 11.326363650235264 15469994 10.1093/protein/gzh076 2004 ProTherm 15835 7425 155 H36Y, H117Y, F123Y Fibroblast growth factor 1 Homo sapiens 72.2 3.8 Yes 44.5 H3PO4 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 5.0, 6.0, 6.0 2AFG, 1JQZ 25.601999855041505, 28.4060001373291, 19.290908986871894, 16.641999912261962, 14.86200008392334, 11.326363650235264 15469994 10.1093/protein/gzh076 2004 ProTherm 16805 7425 155 H36Y, H117Y, F123Y Fibroblast growth factor 1 Homo sapiens -0.81 Yes H3PO4 25 mM 40.7 CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 5.0, 6.0, 6.0 2AFG, 1JQZ 25.601999855041505, 28.4060001373291, 19.290908986871894, 16.641999912261962, 14.86200008392334, 11.326363650235264 15469994 10.1093/protein/gzh076 2004 ProTherm 16819 7425 155 H36Y, H117Y, F123Y Fibroblast growth factor 1 Homo sapiens -1.36 Yes H3PO4 25 mM 39.8 Fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 5.0, 6.0, 6.0 2AFG, 1JQZ 25.601999855041505, 28.4060001373291, 19.290908986871894, 16.641999912261962, 14.86200008392334, 11.326363650235264 15469994 10.1093/protein/gzh076 2004 ProTherm 15826 7427 155 H36Y, L59F, H117Y, F123Y Fibroblast growth factor 1 Homo sapiens 75.6 7.8 Yes 47.6 H3PO4 25 mM Fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 5.0, 7.0, 6.0, 6.0 2AFG, 1JQZ 25.601999855041505, 18.25375008583069, 28.4060001373291, 19.290908986871894, 16.641999912261962, 16.321250081062317, 14.86200008392334, 11.326363650235264 in pocket 15469994 10.1093/protein/gzh076 2004 ProTherm 15837 7427 155 H36Y, L59F, H117Y, F123Y Fibroblast growth factor 1 Homo sapiens 65.2 6.0 Yes 46.7 H3PO4 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 5.0, 7.0, 6.0, 6.0 2AFG, 1JQZ 25.601999855041505, 18.25375008583069, 28.4060001373291, 19.290908986871894, 16.641999912261962, 16.321250081062317, 14.86200008392334, 11.326363650235264 in pocket 15469994 10.1093/protein/gzh076 2004 ProTherm 16807 7427 155 H36Y, L59F, H117Y, F123Y Fibroblast growth factor 1 Homo sapiens -1.28 Yes H3PO4 25 mM 40.7 CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 5.0, 7.0, 6.0, 6.0 2AFG, 1JQZ 25.601999855041505, 18.25375008583069, 28.4060001373291, 19.290908986871894, 16.641999912261962, 16.321250081062317, 14.86200008392334, 11.326363650235264 in pocket 15469994 10.1093/protein/gzh076 2004 ProTherm 16821 7427 155 H36Y, L59F, H117Y, F123Y Fibroblast growth factor 1 Homo sapiens -1.64 Yes H3PO4 25 mM 39.8 Fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 5.0, 7.0, 6.0, 6.0 2AFG, 1JQZ 25.601999855041505, 18.25375008583069, 28.4060001373291, 19.290908986871894, 16.641999912261962, 16.321250081062317, 14.86200008392334, 11.326363650235264 in pocket 15469994 10.1093/protein/gzh076 2004 ProTherm 10329 4368 155 V46W Fibroblast growth factor 1 Homo sapiens 0.91 -0.96 4.49 4.95 Yes (>80%) ADA (N-(2-acetamide)iminodiaceticacid) 25.0 CD, Fluorescence GdnHCl 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0 2AFG, 1JQZ 22.49000004359654, 16.137142998831614 in pocket 19695265 10.1016/j.jmb.2009.08.026 2009 ProTherm 16237 7662 155 Q55P, K133E Fibroblast growth factor 1 Homo sapiens 74.5 -7.1 yes 2.0 47.4 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 1.0, 7.0 2AFG, 1JQZ 27.039999771118165, 26.467777676052517, 38.985555013020836, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16248 7662 155 Q55P, K133E Fibroblast growth factor 1 Homo sapiens 72.5 -6.4 yes 2.0 46.2 sodium phosphate 25 mM fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 1.0, 7.0 2AFG, 1JQZ 27.039999771118165, 26.467777676052517, 38.985555013020836, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16259 7662 155 Q55P, K133E Fibroblast growth factor 1 Homo sapiens 72.2 -8.1 yes 2.0 48.8 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 1.0, 7.0 2AFG, 1JQZ 27.039999771118165, 26.467777676052517, 38.985555013020836, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16270 7662 155 Q55P, K133E Fibroblast growth factor 1 Homo sapiens 64.1 8.2 yes 2.0 45.9 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 1.0, 7.0 2AFG, 1JQZ 27.039999771118165, 26.467777676052517, 38.985555013020836, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16239 7664 155 Q55P, S62I, K133E Fibroblast growth factor 1 Homo sapiens 90.1 -14.9 yes 2.0 55.2 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 1.0, 6.0, 7.0 2AFG, 1JQZ 27.039999771118165, 32.32499980926514, 26.467777676052517, 38.985555013020836, 18.179999669392902, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16250 7664 155 Q55P, S62I, K133E Fibroblast growth factor 1 Homo sapiens 93.5 -14.5 yes 2.0 54.3 sodium phosphate 25 mM fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 1.0, 6.0, 7.0 2AFG, 1JQZ 27.039999771118165, 32.32499980926514, 26.467777676052517, 38.985555013020836, 18.179999669392902, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16261 7664 155 Q55P, S62I, K133E Fibroblast growth factor 1 Homo sapiens 82.4 -15.6 yes 2.0 56.3 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 1.0, 6.0, 7.0 2AFG, 1JQZ 27.039999771118165, 32.32499980926514, 26.467777676052517, 38.985555013020836, 18.179999669392902, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16272 7664 155 Q55P, S62I, K133E Fibroblast growth factor 1 Homo sapiens 69.6 0.9 yes 2.0 53.2 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 1.0, 6.0, 7.0 2AFG, 1JQZ 27.039999771118165, 32.32499980926514, 26.467777676052517, 38.985555013020836, 18.179999669392902, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16240 7665 155 Q55P, S62I, K133E, H108G Fibroblast growth factor 1 Homo sapiens 101.6 -20.9 yes 2.0 61.2 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 1.0, 6.0, 6.0, 7.0 2AFG, 1JQZ 27.039999771118165, 32.32499980926514, 29.013000297546387, 26.467777676052517, 38.985555013020836, 18.179999669392902, 11.58700008392334, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16251 7665 155 Q55P, S62I, K133E, H108G Fibroblast growth factor 1 Homo sapiens 101.1 -20.6 yes 2.0 60.4 sodium phosphate 25 mM fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 1.0, 6.0, 6.0, 7.0 2AFG, 1JQZ 27.039999771118165, 32.32499980926514, 29.013000297546387, 26.467777676052517, 38.985555013020836, 18.179999669392902, 11.58700008392334, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16262 7665 155 Q55P, S62I, K133E, H108G Fibroblast growth factor 1 Homo sapiens 83.4 -21.0 yes 2.0 61.7 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 1.0, 6.0, 6.0, 7.0 2AFG, 1JQZ 27.039999771118165, 32.32499980926514, 29.013000297546387, 26.467777676052517, 38.985555013020836, 18.179999669392902, 11.58700008392334, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16273 7665 155 Q55P, S62I, K133E, H108G Fibroblast growth factor 1 Homo sapiens 75.5 -5.1 yes 2.0 59.2 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 1.0, 6.0, 6.0, 7.0 2AFG, 1JQZ 27.039999771118165, 32.32499980926514, 29.013000297546387, 26.467777676052517, 38.985555013020836, 18.179999669392902, 11.58700008392334, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16241 7666 155 Q55P, S62I, K127N Fibroblast growth factor 1 Homo sapiens 108.5 -18.2 yes 2.0 58.5 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 1.0, 6.0, 8.0 2AFG, 1JQZ 27.039999771118165, 32.32499980926514, 40.181111653645836, 38.985555013020836, 18.179999669392902, 13.921111000908745 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16252 7666 155 Q55P, S62I, K127N Fibroblast growth factor 1 Homo sapiens 107.2 -16.8 yes 2.0 56.6 sodium phosphate 25 mM fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 1.0, 6.0, 8.0 2AFG, 1JQZ 27.039999771118165, 32.32499980926514, 40.181111653645836, 38.985555013020836, 18.179999669392902, 13.921111000908745 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16263 7666 155 Q55P, S62I, K127N Fibroblast growth factor 1 Homo sapiens 90.0 -16.3 yes 2.0 57.0 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 1.0, 6.0, 8.0 2AFG, 1JQZ 27.039999771118165, 32.32499980926514, 40.181111653645836, 38.985555013020836, 18.179999669392902, 13.921111000908745 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16274 7666 155 Q55P, S62I, K127N Fibroblast growth factor 1 Homo sapiens 90.0 -6.3 yes 2.0 60.4 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 1.0, 6.0, 8.0 2AFG, 1JQZ 27.039999771118165, 32.32499980926514, 40.181111653645836, 38.985555013020836, 18.179999669392902, 13.921111000908745 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16242 7667 155 Q55P, S62I, K127N, H108G Fibroblast growth factor 1 Homo sapiens 120.8 -23.8 yes 2.0 64.1 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 1.0, 6.0, 6.0, 8.0 2AFG, 1JQZ 27.039999771118165, 32.32499980926514, 29.013000297546387, 40.181111653645836, 38.985555013020836, 18.179999669392902, 11.58700008392334, 13.921111000908745 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16253 7667 155 Q55P, S62I, K127N, H108G Fibroblast growth factor 1 Homo sapiens 130.7 -23.4 yes 2.0 63.2 sodium phosphate 25 mM fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 1.0, 6.0, 6.0, 8.0 2AFG, 1JQZ 27.039999771118165, 32.32499980926514, 29.013000297546387, 40.181111653645836, 38.985555013020836, 18.179999669392902, 11.58700008392334, 13.921111000908745 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16264 7667 155 Q55P, S62I, K127N, H108G Fibroblast growth factor 1 Homo sapiens 99.8 -22.2 yes 2.0 62.9 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 1.0, 6.0, 6.0, 8.0 2AFG, 1JQZ 27.039999771118165, 32.32499980926514, 29.013000297546387, 40.181111653645836, 38.985555013020836, 18.179999669392902, 11.58700008392334, 13.921111000908745 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16275 7667 155 Q55P, S62I, K127N, H108G Fibroblast growth factor 1 Homo sapiens 97.4 -12.2 yes 2.0 66.3 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 1.0, 6.0, 6.0, 8.0 2AFG, 1JQZ 27.039999771118165, 32.32499980926514, 29.013000297546387, 40.181111653645836, 38.985555013020836, 18.179999669392902, 11.58700008392334, 13.921111000908745 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16244 7669 155 Q55P, K127N, K133E Fibroblast growth factor 1 Homo sapiens 76.4 -6.7 yes 2.0 47.0 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 1.0, 8.0, 7.0 2AFG, 1JQZ 27.039999771118165, 40.181111653645836, 26.467777676052517, 38.985555013020836, 13.921111000908745, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16255 7669 155 Q55P, K127N, K133E Fibroblast growth factor 1 Homo sapiens 73.4 -6.2 yes 2.0 46.0 sodium phosphate 25 mM fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 1.0, 8.0, 7.0 2AFG, 1JQZ 27.039999771118165, 40.181111653645836, 26.467777676052517, 38.985555013020836, 13.921111000908745, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16266 7669 155 Q55P, K127N, K133E Fibroblast growth factor 1 Homo sapiens 75.0 -8.3 yes 2.0 49.0 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 1.0, 8.0, 7.0 2AFG, 1JQZ 27.039999771118165, 40.181111653645836, 26.467777676052517, 38.985555013020836, 13.921111000908745, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16277 7669 155 Q55P, K127N, K133E Fibroblast growth factor 1 Homo sapiens 53.0 11.2 yes 2.0 42.9 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 1.0, 8.0, 7.0 2AFG, 1JQZ 27.039999771118165, 40.181111653645836, 26.467777676052517, 38.985555013020836, 13.921111000908745, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16246 7671 155 Q55P, S62I, K127N, K133E Fibroblast growth factor 1 Homo sapiens 96.3 -16.7 yes 2.0 57.0 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 1.0, 6.0, 8.0, 7.0 2AFG, 1JQZ 27.039999771118165, 32.32499980926514, 40.181111653645836, 26.467777676052517, 38.985555013020836, 18.179999669392902, 13.921111000908745, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16257 7671 155 Q55P, S62I, K127N, K133E Fibroblast growth factor 1 Homo sapiens 100.6 -16.1 yes 2.0 55.9 sodium phosphate 25 mM fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 1.0, 6.0, 8.0, 7.0 2AFG, 1JQZ 27.039999771118165, 32.32499980926514, 40.181111653645836, 26.467777676052517, 38.985555013020836, 18.179999669392902, 13.921111000908745, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16268 7671 155 Q55P, S62I, K127N, K133E Fibroblast growth factor 1 Homo sapiens 92.0 -15.0 yes 2.0 55.7 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 1.0, 6.0, 8.0, 7.0 2AFG, 1JQZ 27.039999771118165, 32.32499980926514, 40.181111653645836, 26.467777676052517, 38.985555013020836, 18.179999669392902, 13.921111000908745, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16279 7671 155 Q55P, S62I, K127N, K133E Fibroblast growth factor 1 Homo sapiens 72.0 4.0 yes 2.0 50.1 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 1.0, 6.0, 8.0, 7.0 2AFG, 1JQZ 27.039999771118165, 32.32499980926514, 40.181111653645836, 26.467777676052517, 38.985555013020836, 18.179999669392902, 13.921111000908745, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16247 7672 155 Q55P, S62I, K127N, K133E, H108G Fibroblast growth factor 1 Homo sapiens 105.1 -22.5 yes 2.0 62.8 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 1.0, 6.0, 6.0, 8.0, 7.0 2AFG, 1JQZ 27.039999771118165, 32.32499980926514, 29.013000297546387, 40.181111653645836, 26.467777676052517, 38.985555013020836, 18.179999669392902, 11.58700008392334, 13.921111000908745, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16258 7672 155 Q55P, S62I, K127N, K133E, H108G Fibroblast growth factor 1 Homo sapiens 112.8 -22.1 yes 2.0 61.9 sodium phosphate 25 mM fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 1.0, 6.0, 6.0, 8.0, 7.0 2AFG, 1JQZ 27.039999771118165, 32.32499980926514, 29.013000297546387, 40.181111653645836, 26.467777676052517, 38.985555013020836, 18.179999669392902, 11.58700008392334, 13.921111000908745, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16269 7672 155 Q55P, S62I, K127N, K133E, H108G Fibroblast growth factor 1 Homo sapiens 102.0 -22.5 yes 2.0 63.2 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 1.0, 6.0, 6.0, 8.0, 7.0 2AFG, 1JQZ 27.039999771118165, 32.32499980926514, 29.013000297546387, 40.181111653645836, 26.467777676052517, 38.985555013020836, 18.179999669392902, 11.58700008392334, 13.921111000908745, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16280 7672 155 Q55P, S62I, K127N, K133E, H108G Fibroblast growth factor 1 Homo sapiens 81.6 -4.7 yes 2.0 58.8 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 1.0, 6.0, 6.0, 8.0, 7.0 2AFG, 1JQZ 27.039999771118165, 32.32499980926514, 29.013000297546387, 40.181111653645836, 26.467777676052517, 38.985555013020836, 18.179999669392902, 11.58700008392334, 13.921111000908745, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 238 126 155 L59P Fibroblast growth factor 1 Homo sapiens 76.48 53.54 3.0 yes 43.05 N-(2-acetamido)iminodiacetic acid(ADA) 20 mM NaCl 100 mM DSC Thermal 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0 2AFG, 1JQZ 18.25375008583069, 16.321250081062317 in pocket 11266617 10.1110/ps.37401 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8081 126 155 L59P Fibroblast growth factor 1 Homo sapiens -0.69 yes N-(2-acetamido)iminodiacetic acid(ADA) 20 mM 40.2 NaCl 100 mM DSC Thermal 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0 2AFG, 1JQZ 18.25375008583069, 16.321250081062317 in pocket 11266617 10.1110/ps.37401 2001 ProTherm potapov_with_uniprot_mapping.csv 1702 943 155 L59F Fibroblast growth factor 1 Homo sapiens 70.8 1.5 Yes 41.3 H3PO4 25 mM Fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0 2AFG, 1JQZ 18.25375008583069, 16.321250081062317 in pocket 15469994 10.1093/protein/gzh076 2004 ProTherm 1707 943 155 L59F Fibroblast growth factor 1 Homo sapiens 70.5 2.2 Yes 42.9 H3PO4 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0 2AFG, 1JQZ 18.25375008583069, 16.321250081062317 in pocket 15469994 10.1093/protein/gzh076 2004 ProTherm 2657 943 155 L59F Fibroblast growth factor 1 Homo sapiens 0.72 78.15 3.1 Yes (>80%) 42.85 ADA (N-(2-acetamide)iminodiaceticacid) DSC Thermal 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0 2AFG, 1JQZ 18.25375008583069, 16.321250081062317 in pocket 19695265 10.1016/j.jmb.2009.08.026 2009 ProTherm 8074 943 155 L59F Fibroblast growth factor 1 Homo sapiens -0.47 Yes H3PO4 25 mM 40.7 CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0 2AFG, 1JQZ 18.25375008583069, 16.321250081062317 in pocket 15469994 10.1093/protein/gzh076 2004 ProTherm potapov_with_uniprot_mapping.csv 8151 943 155 L59F Fibroblast growth factor 1 Homo sapiens -0.31 Yes H3PO4 25 mM 39.8 Fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0 2AFG, 1JQZ 18.25375008583069, 16.321250081062317 in pocket 15469994 10.1093/protein/gzh076 2004 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 12706 943 155 L59F Fibroblast growth factor 1 Homo sapiens 1.29 -0.87 6.4 4.97 Yes H3PO4 25 mM 20.15 Fluorescence GdnHCl 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0 2AFG, 1JQZ 18.25375008583069, 16.321250081062317 in pocket 15469994 10.1093/protein/gzh076 2004 ProTherm 10326 4367 155 L59W Fibroblast growth factor 1 Homo sapiens 0.92 -0.81 3.61 3.94 Yes (>80%) ADA (N-(2-acetamide)iminodiaceticacid) 25.0 CD, Fluorescence GdnHCl 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0 2AFG, 1JQZ 18.25375008583069, 16.321250081062317 in pocket 19695265 10.1016/j.jmb.2009.08.026 2009 ProTherm 10331 4367 155 L59W Fibroblast growth factor 1 Homo sapiens 1.23 0.57 6.0 4.88 Yes (>80%) ADA (N-(2-acetamide)iminodiaceticacid) 25.0 CD, Fluorescence GdnHCl 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0 2AFG, 1JQZ 18.25375008583069, 16.321250081062317 in pocket 19695265 10.1016/j.jmb.2009.08.026 2009 ProTherm 15654 7297 155 L59P, L88V, V124L Fibroblast growth factor 1 Homo sapiens 61.42 30.71 -0.7 yes 39.35 N-(2-acetamido)iminodiacetic acid(ADA) 20 mM NaCl 100 mM DSC Thermal 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0, 8.0, 7.0 2AFG, 1JQZ 18.25375008583069, 23.40249991416931, 15.652857235499791, 16.321250081062317, 11.738749861717224, 10.708571297781807 in pocket 11266617 10.1110/ps.37401 2001 ProTherm 16809 7297 155 L59P, L88V, V124L Fibroblast growth factor 1 Homo sapiens 0.14 yes N-(2-acetamido)iminodiacetic acid(ADA) 20 mM 40.2 NaCl 100 mM DSC Thermal 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0, 8.0, 7.0 2AFG, 1JQZ 18.25375008583069, 23.40249991416931, 15.652857235499791, 16.321250081062317, 11.738749861717224, 10.708571297781807 in pocket 11266617 10.1110/ps.37401 2001 ProTherm 15819 7420 155 L59F, H117Y Fibroblast growth factor 1 Homo sapiens 83.3 3.6 Yes 43.4 H3PO4 25 mM Fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0, 6.0 2AFG, 1JQZ 18.25375008583069, 28.4060001373291, 16.321250081062317, 14.86200008392334 in pocket 15469994 10.1093/protein/gzh076 2004 ProTherm 15830 7420 155 L59F, H117Y Fibroblast growth factor 1 Homo sapiens 65.6 2.9 Yes 43.6 H3PO4 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0, 6.0 2AFG, 1JQZ 18.25375008583069, 28.4060001373291, 16.321250081062317, 14.86200008392334 in pocket 15469994 10.1093/protein/gzh076 2004 ProTherm 16800 7420 155 L59F, H117Y Fibroblast growth factor 1 Homo sapiens -0.61 Yes H3PO4 25 mM 40.7 CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0, 6.0 2AFG, 1JQZ 18.25375008583069, 28.4060001373291, 16.321250081062317, 14.86200008392334 in pocket 15469994 10.1093/protein/gzh076 2004 ProTherm 16814 7420 155 L59F, H117Y Fibroblast growth factor 1 Homo sapiens -0.75 Yes H3PO4 25 mM 39.8 Fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0, 6.0 2AFG, 1JQZ 18.25375008583069, 28.4060001373291, 16.321250081062317, 14.86200008392334 in pocket 15469994 10.1093/protein/gzh076 2004 ProTherm 15820 7421 155 L59F, F123Y Fibroblast growth factor 1 Homo sapiens 84.2. 2.8 Yes 42.6 H3PO4 25 mM Fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0, 6.0 2AFG, 1JQZ 18.25375008583069, 19.290908986871894, 16.321250081062317, 11.326363650235264 in pocket 15469994 10.1093/protein/gzh076 2004 ProTherm 15831 7421 155 L59F, F123Y Fibroblast growth factor 1 Homo sapiens 73.8 3.6 Yes 44.3 H3PO4 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0, 6.0 2AFG, 1JQZ 18.25375008583069, 19.290908986871894, 16.321250081062317, 11.326363650235264 in pocket 15469994 10.1093/protein/gzh076 2004 ProTherm 16801 7421 155 L59F, F123Y Fibroblast growth factor 1 Homo sapiens -0.77 Yes H3PO4 25 mM 40.7 CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0, 6.0 2AFG, 1JQZ 18.25375008583069, 19.290908986871894, 16.321250081062317, 11.326363650235264 in pocket 15469994 10.1093/protein/gzh076 2004 ProTherm 16815 7421 155 L59F, F123Y Fibroblast growth factor 1 Homo sapiens -0.58 Yes H3PO4 25 mM 39.8 Fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0, 6.0 2AFG, 1JQZ 18.25375008583069, 19.290908986871894, 16.321250081062317, 11.326363650235264 in pocket 15469994 10.1093/protein/gzh076 2004 ProTherm 15825 7426 155 L59F, H117Y, F123Y Fibroblast growth factor 1 Homo sapiens 81.3 4.5 Yes 44.3 H3PO4 25 mM Fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0, 6.0, 6.0 2AFG, 1JQZ 18.25375008583069, 28.4060001373291, 19.290908986871894, 16.321250081062317, 14.86200008392334, 11.326363650235264 in pocket 15469994 10.1093/protein/gzh076 2004 ProTherm 15836 7426 155 L59F, H117Y, F123Y Fibroblast growth factor 1 Homo sapiens 62.3 4.5 Yes 45.2 H3PO4 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0, 6.0, 6.0 2AFG, 1JQZ 18.25375008583069, 28.4060001373291, 19.290908986871894, 16.321250081062317, 14.86200008392334, 11.326363650235264 in pocket 15469994 10.1093/protein/gzh076 2004 ProTherm 16806 7426 155 L59F, H117Y, F123Y Fibroblast growth factor 1 Homo sapiens -0.96 Yes H3PO4 25 mM 40.7 CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0, 6.0, 6.0 2AFG, 1JQZ 18.25375008583069, 28.4060001373291, 19.290908986871894, 16.321250081062317, 14.86200008392334, 11.326363650235264 in pocket 15469994 10.1093/protein/gzh076 2004 ProTherm 16820 7426 155 L59F, H117Y, F123Y Fibroblast growth factor 1 Homo sapiens -0.94 Yes H3PO4 25 mM 39.8 Fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0, 6.0, 6.0 2AFG, 1JQZ 18.25375008583069, 28.4060001373291, 19.290908986871894, 16.321250081062317, 14.86200008392334, 11.326363650235264 in pocket 15469994 10.1093/protein/gzh076 2004 ProTherm 16036 7532 155 L59F, F147W Fibroblast growth factor 1 Homo sapiens 0.98 78.87 4.1 Yes (>80%) 43.85 ADA (N-(2-acetamide)iminodiaceticacid) DSC Thermal 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0, 9.0 2AFG, 1JQZ 18.25375008583069, 14.910909219221635, 16.321250081062317, 10.41999998959628 in pocket 19695265 10.1016/j.jmb.2009.08.026 2009 ProTherm 17004 7956 155 L59W, F147W Fibroblast growth factor 1 Homo sapiens 1.32 0.93 5.74 4.33 Yes (>80%) ADA (N-(2-acetamide)iminodiaceticacid) 25.0 CD, Fluorescence GdnHCl 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0, 9.0 2AFG, 1JQZ 18.25375008583069, 14.910909219221635, 16.321250081062317, 10.41999998959628 in pocket 19695265 10.1016/j.jmb.2009.08.026 2009 ProTherm 17006 7958 155 L59F, C98T, C132V, F147W Fibroblast growth factor 1 Homo sapiens 1.13 0.1 5.11 4.52 Yes (>80%) ADA (N-(2-acetamide)iminodiaceticacid) 25.0 CD, Fluorescence GdnHCl 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0, 8.0, 4.0, 9.0 2AFG, 1JQZ 18.25375008583069, 15.863333384195963, 32.451666514078774, 14.910909219221635, 16.321250081062317, 11.339999993642172, 14.473333517710367, 10.41999998959628 in pocket 19695265 10.1016/j.jmb.2009.08.026 2009 ProTherm 16238 7663 155 S62I, K133E Fibroblast growth factor 1 Homo sapiens 75.1 -8.5 yes 2.0 48.8 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 6.0, 7.0 2AFG, 1JQZ 32.32499980926514, 26.467777676052517, 18.179999669392902, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16249 7663 155 S62I, K133E Fibroblast growth factor 1 Homo sapiens 74.0 -7.8 yes 2.0 47.6 sodium phosphate 25 mM fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 6.0, 7.0 2AFG, 1JQZ 32.32499980926514, 26.467777676052517, 18.179999669392902, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16260 7663 155 S62I, K133E Fibroblast growth factor 1 Homo sapiens 81.4 -9.0 yes 2.0 49.7 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 6.0, 7.0 2AFG, 1JQZ 32.32499980926514, 26.467777676052517, 18.179999669392902, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16271 7663 155 S62I, K133E Fibroblast growth factor 1 Homo sapiens 75.8 7.4 yes 2.0 46.7 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 6.0, 7.0 2AFG, 1JQZ 32.32499980926514, 26.467777676052517, 18.179999669392902, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16245 7670 155 S62I, K127N, K133E Fibroblast growth factor 1 Homo sapiens 82.2 -8.2 yes 2.0 48.5 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 6.0, 8.0, 7.0 2AFG, 1JQZ 32.32499980926514, 40.181111653645836, 26.467777676052517, 18.179999669392902, 13.921111000908745, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16256 7670 155 S62I, K127N, K133E Fibroblast growth factor 1 Homo sapiens 83.3 -7.7 yes 2.0 47.5 sodium phosphate 25 mM fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 6.0, 8.0, 7.0 2AFG, 1JQZ 32.32499980926514, 40.181111653645836, 26.467777676052517, 18.179999669392902, 13.921111000908745, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16267 7670 155 S62I, K127N, K133E Fibroblast growth factor 1 Homo sapiens 75.6 -8.6 yes 2.0 49.3 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 6.0, 8.0, 7.0 2AFG, 1JQZ 32.32499980926514, 40.181111653645836, 26.467777676052517, 18.179999669392902, 13.921111000908745, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16278 7670 155 S62I, K127N, K133E Fibroblast growth factor 1 Homo sapiens 57.6 10.8 yes 2.0 43.3 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 6.0, 8.0, 7.0 2AFG, 1JQZ 32.32499980926514, 40.181111653645836, 26.467777676052517, 18.179999669392902, 13.921111000908745, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 9055 3902 155 G77A Fibroblast growth factor 1 Homo sapiens 0.79 1.43 3.61 4.59 yes N-(2-acetamido)-iminodiacetic acid 20 mM 25.0 NaCl 100 mM Fluorescence GdnHCl 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 4.0 2AFG, 1JQZ 24.480000019073486, 16.40750002861023 in pocket 12729767 10.1016/s0022-2836(03)00321-8 2003 ProTherm 9056 3903 155 G77N Fibroblast growth factor 1 Homo sapiens 0.87 0.79 4.25 4.9 yes N-(2-acetamido)-iminodiacetic acid 20 mM 25.0 NaCl 100 mM Fluorescence GdnHCl 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 4.0 2AFG, 1JQZ 24.480000019073486, 16.40750002861023 in pocket 12729767 10.1016/s0022-2836(03)00321-8 2003 ProTherm 239 127 155 L88V Fibroblast growth factor 1 Homo sapiens 44.69 46.93 -8.5 yes 31.55 N-(2-acetamido)iminodiacetic acid(ADA) 20 mM NaCl 100 mM DSC Thermal 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0 2AFG, 1JQZ 23.40249991416931, 11.738749861717224 in pocket 11266617 10.1110/ps.37401 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8082 127 155 L88V Fibroblast growth factor 1 Homo sapiens 1.46 yes N-(2-acetamido)iminodiacetic acid(ADA) 20 mM 40.2 NaCl 100 mM DSC Thermal 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0 2AFG, 1JQZ 23.40249991416931, 11.738749861717224 in pocket 11266617 10.1110/ps.37401 2001 ProTherm potapov_with_uniprot_mapping.csv 15653 7296 155 L88V, V124L Fibroblast growth factor 1 Homo sapiens 55.69 40.1 -4.6 yes 35.45 N-(2-acetamido)iminodiacetic acid(ADA) 20 mM NaCl 100 mM DSC Thermal 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0, 7.0 2AFG, 1JQZ 23.40249991416931, 15.652857235499791, 11.738749861717224, 10.708571297781807 in pocket 11266617 10.1110/ps.37401 2001 ProTherm 16808 7296 155 L88V, V124L Fibroblast growth factor 1 Homo sapiens 0.88 yes N-(2-acetamido)iminodiacetic acid(ADA) 20 mM 40.2 NaCl 100 mM DSC Thermal 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0, 7.0 2AFG, 1JQZ 23.40249991416931, 15.652857235499791, 11.738749861717224, 10.708571297781807 in pocket 11266617 10.1110/ps.37401 2001 ProTherm 4196 2129 155 C98S Fibroblast growth factor 1 Homo sapiens 32.86 -13.0 yes 26.45 GuHCl/ADA 0.7 M DSC Thermal 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0 2AFG, 1JQZ 15.863333384195963, 11.339999993642172 10852713 10.1021/bi9927742 2000 ProTherm AUTOMUTE_S1749.csv 11124 2129 155 C98S Fibroblast growth factor 1 Homo sapiens 1.31 3.63 yes GuHCl/ADA 0.7 M 25.0 DSC GdnHCl 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0 2AFG, 1JQZ 15.863333384195963, 11.339999993642172 10852713 10.1021/bi9927742 2000 ProTherm 11128 2129 155 C98S Fibroblast growth factor 1 Homo sapiens 1.91 yes GuHCl/ADA 0.7 M 25.0 DSC Thermal 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0 2AFG, 1JQZ 15.863333384195963, 11.339999993642172 10852713 10.1021/bi9927742 2000 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 12481 2129 155 C98S Fibroblast growth factor 1 Homo sapiens 0.96 1.33 4.78 4.99 yes 2.0 Sodium phosphate 50mM 25.0 Fluorescence GdnHCl 8.0 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0 2AFG, 1JQZ 15.863333384195963, 11.339999993642172 25312602 10.1016/j.ijbiomac.2014.10.003 2015 ProTherm 12480 5777 155 C98A Fibroblast growth factor 1 Homo sapiens 1.01 1.14 4.97 4.9 yes 2.0 Sodium phosphate 50mM 25.0 Fluorescence GdnHCl 8.0 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0 2AFG, 1JQZ 15.863333384195963, 11.339999993642172 25312601 10.1111/1462-2920.12248 2014 ProTherm 12482 5778 155 C98T Fibroblast growth factor 1 Homo sapiens 1.03 1.21 4.9 4.73 yes 2.0 Sodium phosphate 50mM 25.0 Fluorescence GdnHCl 8.0 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0 2AFG, 1JQZ 15.863333384195963, 11.339999993642172 25312603 10.1016/j.ijbiomac.2014.10.002 2015 ProTherm 12483 5779 155 C98V Fibroblast growth factor 1 Homo sapiens 0.7 2.6 3.51 4.99 yes 2.0 Sodium phosphate 50mM 25.0 Fluorescence GdnHCl 8.0 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0 2AFG, 1JQZ 15.863333384195963, 11.339999993642172 25312604 10.1007/s10334-014-0465-0 2015 ProTherm 14818 6956 155 C98S, C132S Fibroblast growth factor 1 Homo sapiens 30.5 -13.5 yes 25.95 GuHCl/ADA 0.7 M DSC Thermal 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0, 4.0 2AFG, 1JQZ 15.863333384195963, 32.451666514078774, 11.339999993642172, 14.473333517710367 10852713 10.1021/bi9927742 2000 ProTherm 15409 6956 155 C98S, C132S Fibroblast growth factor 1 Homo sapiens 1.79 3.18 yes GuHCl/ADA 0.7 M 25.0 DSC GdnHCl 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0, 4.0 2AFG, 1JQZ 15.863333384195963, 32.451666514078774, 11.339999993642172, 14.473333517710367 10852713 10.1021/bi9927742 2000 ProTherm 15411 6956 155 C98S, C132S Fibroblast growth factor 1 Homo sapiens 1.82 yes GuHCl/ADA 0.7 M 25.0 DSC Thermal 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0, 4.0 2AFG, 1JQZ 15.863333384195963, 32.451666514078774, 11.339999993642172, 14.473333517710367 10852713 10.1021/bi9927742 2000 ProTherm 17005 7957 155 C98T, C132V Fibroblast growth factor 1 Homo sapiens 0.81 -1.46 4.18 5.19 Yes (>80%) ADA (N-(2-acetamide)iminodiaceticacid) 25.0 CD, Fluorescence GdnHCl 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0, 4.0 2AFG, 1JQZ 15.863333384195963, 32.451666514078774, 11.339999993642172, 14.473333517710367 19695265 10.1016/j.jmb.2009.08.026 2009 ProTherm 17007 7957 155 C98T, C132V Fibroblast growth factor 1 Homo sapiens 1.21 0.45 5.76 4.76 Yes (>80%) ADA (N-(2-acetamide)iminodiaceticacid) 25.0 CD, Fluorescence GdnHCl 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0, 4.0 2AFG, 1JQZ 15.863333384195963, 32.451666514078774, 11.339999993642172, 14.473333517710367 19695265 10.1016/j.jmb.2009.08.026 2009 ProTherm 2658 1347 155 F100W Fibroblast growth factor 1 Homo sapiens -0.07 63.58 -0.3 Yes (>80%) 39.45 ADA (N-(2-acetamide)iminodiaceticacid) DSC Thermal 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 9.0 2AFG, 1JQZ 19.249999826604668, 11.505454496903853 in pocket 19695265 10.1016/j.jmb.2009.08.026 2009 ProTherm 10327 1347 155 F100W Fibroblast growth factor 1 Homo sapiens 1.13 0.1 5.33 4.71 Yes (>80%) ADA (N-(2-acetamide)iminodiaceticacid) 25.0 CD, Fluorescence GdnHCl 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 9.0 2AFG, 1JQZ 19.249999826604668, 11.505454496903853 in pocket 19695265 10.1016/j.jmb.2009.08.026 2009 ProTherm 4198 2131 155 H108G Fibroblast growth factor 1 Homo sapiens 79.49 7.3 yes 46.75 GuHCl/ADA 0.7 M DSC Thermal 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 6.0 2AFG, 1JQZ 29.013000297546387, 11.58700008392334 10852713 10.1021/bi9927742 2000 ProTherm AUTOMUTE_S1749.csv 8156 2131 155 H108G Fibroblast growth factor 1 Homo sapiens -1.6 yes N-(2-acetamido)iminodiacetic acid (ADA) 20 mM 39.6 NaCl 0.1 M DSC Thermal 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 6.0 2AFG, 1JQZ 29.013000297546387, 11.58700008392334 10852713 10.1021/bi9927742 2000 ProTherm 9052 2131 155 H108G Fibroblast growth factor 1 Homo sapiens 1.45 -1.79 6.84 4.73 yes N-(2-acetamido)-iminodiacetic acid 20 mM 25.0 NaCl 100 mM Fluorescence GdnHCl 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 6.0 2AFG, 1JQZ 29.013000297546387, 11.58700008392334 12729767 10.1016/s0022-2836(03)00321-8 2003 ProTherm 11127 2131 155 H108G Fibroblast growth factor 1 Homo sapiens -1.31 6.26 yes GuHCl/ADA 0.7 M 25.0 DSC GdnHCl 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 6.0 2AFG, 1JQZ 29.013000297546387, 11.58700008392334 10852713 10.1021/bi9927742 2000 ProTherm 11130 2131 155 H108G Fibroblast growth factor 1 Homo sapiens -0.55 yes GuHCl/ADA 0.7 M 25.0 DSC Thermal 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 6.0 2AFG, 1JQZ 29.013000297546387, 11.58700008392334 10852713 10.1021/bi9927742 2000 ProTherm khan_protherm_data_mapped.csv 9053 3900 155 H108A Fibroblast growth factor 1 Homo sapiens 0.95 0.43 4.61 4.88 yes N-(2-acetamido)-iminodiacetic acid 20 mM 25.0 NaCl 100 mM Fluorescence GdnHCl 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 6.0 2AFG, 1JQZ 29.013000297546387, 11.58700008392334 12729767 10.1016/s0022-2836(03)00321-8 2003 ProTherm 9054 3901 155 H108N Fibroblast growth factor 1 Homo sapiens 1.13 -0.29 5.33 4.73 yes N-(2-acetamido)-iminodiacetic acid 20 mM 25.0 NaCl 100 mM Fluorescence GdnHCl 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 6.0 2AFG, 1JQZ 29.013000297546387, 11.58700008392334 12729767 10.1016/s0022-2836(03)00321-8 2003 ProTherm 1703 944 155 H117Y Fibroblast growth factor 1 Homo sapiens 75.7 1.9 Yes 41.7 H3PO4 25 mM Fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 6.0 2AFG, 1JQZ 28.4060001373291, 14.86200008392334 15469994 10.1093/protein/gzh076 2004 ProTherm 1708 944 155 H117Y Fibroblast growth factor 1 Homo sapiens 66.3 0.5 Yes 41.2 H3PO4 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 6.0 2AFG, 1JQZ 28.4060001373291, 14.86200008392334 15469994 10.1093/protein/gzh076 2004 ProTherm 8075 944 155 H117Y Fibroblast growth factor 1 Homo sapiens -0.1 Yes H3PO4 25 mM 40.7 CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 6.0 2AFG, 1JQZ 28.4060001373291, 14.86200008392334 15469994 10.1093/protein/gzh076 2004 ProTherm khan_protherm_data_mapped.csv 8152 944 155 H117Y Fibroblast growth factor 1 Homo sapiens -0.4 Yes H3PO4 25 mM 39.8 Fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 6.0 2AFG, 1JQZ 28.4060001373291, 14.86200008392334 15469994 10.1093/protein/gzh076 2004 ProTherm 12707 944 155 H117Y Fibroblast growth factor 1 Homo sapiens 1.27 -0.44 5.97 4.69 Yes H3PO4 25 mM 20.15 Fluorescence GdnHCl 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 6.0 2AFG, 1JQZ 28.4060001373291, 14.86200008392334 15469994 10.1093/protein/gzh076 2004 ProTherm 15821 7422 155 H117Y, F123Y Fibroblast growth factor 1 Homo sapiens 75.6 3.1 Yes 42.9 H3PO4 25 mM Fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 6.0, 6.0 2AFG, 1JQZ 28.4060001373291, 19.290908986871894, 14.86200008392334, 11.326363650235264 15469994 10.1093/protein/gzh076 2004 ProTherm 15832 7422 155 H117Y, F123Y Fibroblast growth factor 1 Homo sapiens 68.1 2.4 Yes 43.1 H3PO4 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 6.0, 6.0 2AFG, 1JQZ 28.4060001373291, 19.290908986871894, 14.86200008392334, 11.326363650235264 15469994 10.1093/protein/gzh076 2004 ProTherm 16802 7422 155 H117Y, F123Y Fibroblast growth factor 1 Homo sapiens -0.5 Yes H3PO4 25 mM 40.7 CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 6.0, 6.0 2AFG, 1JQZ 28.4060001373291, 19.290908986871894, 14.86200008392334, 11.326363650235264 15469994 10.1093/protein/gzh076 2004 ProTherm 16816 7422 155 H117Y, F123Y Fibroblast growth factor 1 Homo sapiens -0.66 Yes H3PO4 25 mM 39.8 Fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 6.0, 6.0 2AFG, 1JQZ 28.4060001373291, 19.290908986871894, 14.86200008392334, 11.326363650235264 15469994 10.1093/protein/gzh076 2004 ProTherm 9057 3904 155 A118G Fibroblast growth factor 1 Homo sapiens 1.0 0.41 4.64 4.64 yes N-(2-acetamido)-iminodiacetic acid 20 mM 25.0 NaCl 100 mM Fluorescence GdnHCl 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 3.0 2AFG, 1JQZ 26.45999946594238, 13.822000122070312 in pocket 12729767 10.1016/s0022-2836(03)00321-8 2003 ProTherm 9051 3899 155 N121G Fibroblast growth factor 1 Homo sapiens 1.1 -0.38 5.43 4.95 yes N-(2-acetamido)-iminodiacetic acid 20 mM 25.0 NaCl 100 mM Fluorescence GdnHCl 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 2.0 2AFG, 1JQZ 37.50124955177307, 15.798750042915344 12729767 10.1016/s0022-2836(03)00321-8 2003 ProTherm 1704 945 155 F123Y Fibroblast growth factor 1 Homo sapiens 79.6 1.6 Yes 41.4 H3PO4 25 mM Fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 6.0 2AFG, 1JQZ 19.290908986871894, 11.326363650235264 15469994 10.1093/protein/gzh076 2004 ProTherm 1709 945 155 F123Y Fibroblast growth factor 1 Homo sapiens 72.6 1.6 Yes 42.3 H3PO4 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 6.0 2AFG, 1JQZ 19.290908986871894, 11.326363650235264 15469994 10.1093/protein/gzh076 2004 ProTherm 8076 945 155 F123Y Fibroblast growth factor 1 Homo sapiens -0.33 Yes H3PO4 25 mM 40.7 CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 6.0 2AFG, 1JQZ 19.290908986871894, 11.326363650235264 15469994 10.1093/protein/gzh076 2004 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8153 945 155 F123Y Fibroblast growth factor 1 Homo sapiens -0.33 Yes H3PO4 25 mM 39.8 Fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 6.0 2AFG, 1JQZ 19.290908986871894, 11.326363650235264 15469994 10.1093/protein/gzh076 2004 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 12708 945 155 F123Y Fibroblast growth factor 1 Homo sapiens 1.22 -0.94 6.47 5.3 Yes H3PO4 25 mM 20.15 Fluorescence GdnHCl 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 6.0 2AFG, 1JQZ 19.290908986871894, 11.326363650235264 15469994 10.1093/protein/gzh076 2004 ProTherm 240 128 155 V124L Fibroblast growth factor 1 Homo sapiens 52.34 43.44 -3.3 yes 36.75 N-(2-acetamido)iminodiacetic acid(ADA) 20 mM NaCl 100 mM DSC Thermal 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0 2AFG, 1JQZ 15.652857235499791, 10.708571297781807 in pocket 11266617 10.1110/ps.37401 2001 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 8083 128 155 V124L Fibroblast growth factor 1 Homo sapiens 0.57 yes N-(2-acetamido)iminodiacetic acid(ADA) 20 mM 40.2 NaCl 100 mM DSC Thermal 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0 2AFG, 1JQZ 15.652857235499791, 10.708571297781807 in pocket 11266617 10.1110/ps.37401 2001 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 1705 946 155 V124I Fibroblast growth factor 1 Homo sapiens 61.4 -0.3 Yes 39.5 H3PO4 25 mM Fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0 2AFG, 1JQZ 15.652857235499791, 10.708571297781807 in pocket 15469994 10.1093/protein/gzh076 2004 ProTherm 1710 946 155 V124I Fibroblast growth factor 1 Homo sapiens 61.6 -0.4 Yes 40.3 H3PO4 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0 2AFG, 1JQZ 15.652857235499791, 10.708571297781807 in pocket 15469994 10.1093/protein/gzh076 2004 ProTherm 8077 946 155 V124I Fibroblast growth factor 1 Homo sapiens 0.11 Yes H3PO4 25 mM 40.7 CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0 2AFG, 1JQZ 15.652857235499791, 10.708571297781807 in pocket 15469994 10.1093/protein/gzh076 2004 ProTherm potapov_with_uniprot_mapping.csv 8154 946 155 V124I Fibroblast growth factor 1 Homo sapiens 0.08 Yes H3PO4 25 mM 39.8 Fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0 2AFG, 1JQZ 15.652857235499791, 10.708571297781807 in pocket 15469994 10.1093/protein/gzh076 2004 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 12709 946 155 V124I Fibroblast growth factor 1 Homo sapiens 1.12 -0.06 5.59 5.03 Yes H3PO4 25 mM 20.15 Fluorescence GdnHCl 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0 2AFG, 1JQZ 15.652857235499791, 10.708571297781807 in pocket 15469994 10.1093/protein/gzh076 2004 ProTherm 4450 2246 155 K127N Fibroblast growth factor 1 Homo sapiens 75.6 -3.5 yes 2.0 43.8 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0 2AFG, 1JQZ 40.181111653645836, 13.921111000908745 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 4456 2246 155 K127N Fibroblast growth factor 1 Homo sapiens 72.6 -2.8 yes 2.0 42.6 sodium phosphate 25 mM fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0 2AFG, 1JQZ 40.181111653645836, 13.921111000908745 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 4462 2246 155 K127N Fibroblast growth factor 1 Homo sapiens 68.1 -2.5 yes 2.0 43.2 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0 2AFG, 1JQZ 40.181111653645836, 13.921111000908745 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 4468 2246 155 K127N Fibroblast growth factor 1 Homo sapiens 65.1 7.6 yes 2.0 46.5 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0 2AFG, 1JQZ 40.181111653645836, 13.921111000908745 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 4451 2247 155 K127A Fibroblast growth factor 1 Homo sapiens 65.0 0.3 yes 2.0 40.0 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0 2AFG, 1JQZ 40.181111653645836, 13.921111000908745 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 4457 2247 155 K127A Fibroblast growth factor 1 Homo sapiens 66.0 0.2 yes 2.0 39.6 sodium phosphate 25 mM fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0 2AFG, 1JQZ 40.181111653645836, 13.921111000908745 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 4463 2247 155 K127A Fibroblast growth factor 1 Homo sapiens 54.0 0.9 yes 2.0 39.8 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0 2AFG, 1JQZ 40.181111653645836, 13.921111000908745 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 4469 2247 155 K127A Fibroblast growth factor 1 Homo sapiens 57.3 10.4 yes 2.0 43.7 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0 2AFG, 1JQZ 40.181111653645836, 13.921111000908745 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 4452 2248 155 K127E Fibroblast growth factor 1 Homo sapiens 62.4 0.2 yes 2.0 40.1 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0 2AFG, 1JQZ 40.181111653645836, 13.921111000908745 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 4458 2248 155 K127E Fibroblast growth factor 1 Homo sapiens 63.9 0.4 yes 2.0 39.4 sodium phosphate 25 mM fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0 2AFG, 1JQZ 40.181111653645836, 13.921111000908745 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 4464 2248 155 K127E Fibroblast growth factor 1 Homo sapiens 60.5 -0.3 yes 2.0 41.0 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0 2AFG, 1JQZ 40.181111653645836, 13.921111000908745 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 4470 2248 155 K127E Fibroblast growth factor 1 Homo sapiens 57.1 15.6 yes 2.0 38.5 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0 2AFG, 1JQZ 40.181111653645836, 13.921111000908745 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16243 7668 155 K127N, K133E Fibroblast growth factor 1 Homo sapiens 66.6 -1.5 yes 2.0 41.8 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0, 7.0 2AFG, 1JQZ 40.181111653645836, 26.467777676052517, 13.921111000908745, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16254 7668 155 K127N, K133E Fibroblast growth factor 1 Homo sapiens 64.4 -1.6 yes 2.0 41.4 sodium phosphate 25 mM fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0, 7.0 2AFG, 1JQZ 40.181111653645836, 26.467777676052517, 13.921111000908745, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16265 7668 155 K127N, K133E Fibroblast growth factor 1 Homo sapiens 63.0 1.9 yes 2.0 38.8 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0, 7.0 2AFG, 1JQZ 40.181111653645836, 26.467777676052517, 13.921111000908745, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 16276 7668 155 K127N, K133E Fibroblast growth factor 1 Homo sapiens 53.0 21.1 yes 2.0 33.0 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 8.0, 7.0 2AFG, 1JQZ 40.181111653645836, 26.467777676052517, 13.921111000908745, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 4197 2130 155 C132S Fibroblast growth factor 1 Homo sapiens 52.44 -2.0 yes 37.45 GuHCl/ADA 0.7 M DSC Thermal 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 4.0 2AFG, 1JQZ 32.451666514078774, 14.473333517710367 10852713 10.1021/bi9927742 2000 ProTherm AUTOMUTE_S1749.csv 8155 2130 155 C132S Fibroblast growth factor 1 Homo sapiens 0.26 yes N-(2-acetamido)iminodiacetic acid (ADA) 20 mM 39.6 NaCl 0.1 M DSC Thermal 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 4.0 2AFG, 1JQZ 32.451666514078774, 14.473333517710367 10852713 10.1021/bi9927742 2000 ProTherm khan_protherm_data_mapped.csv 11125 2130 155 C132S Fibroblast growth factor 1 Homo sapiens 0.93 4.04 yes GuHCl/ADA 0.7 M 25.0 DSC GdnHCl 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 4.0 2AFG, 1JQZ 32.451666514078774, 14.473333517710367 10852713 10.1021/bi9927742 2000 ProTherm 11129 2130 155 C132S Fibroblast growth factor 1 Homo sapiens 0.62 yes GuHCl/ADA 0.7 M 25.0 DSC Thermal 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 4.0 2AFG, 1JQZ 32.451666514078774, 14.473333517710367 10852713 10.1021/bi9927742 2000 ProTherm 12485 2130 155 C132S Fibroblast growth factor 1 Homo sapiens 1.19 0.21 5.9 4.97 yes 2.0 Sodium phosphate 50mM 25.0 Fluorescence GdnHCl 8.0 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 4.0 2AFG, 1JQZ 32.451666514078774, 14.473333517710367 25312606 10.1111/nph.13070 2014 ProTherm 10330 4369 155 C132I Fibroblast growth factor 1 Homo sapiens 1.03 -0.36 4.8 4.68 Yes (>80%) ADA (N-(2-acetamide)iminodiaceticacid) 25.0 CD, Fluorescence GdnHCl 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 4.0 2AFG, 1JQZ 32.451666514078774, 14.473333517710367 19695265 10.1016/j.jmb.2009.08.026 2009 ProTherm 12484 5780 155 C132A Fibroblast growth factor 1 Homo sapiens 1.32 -0.34 6.45 4.9 yes 2.0 Sodium phosphate 50mM 25.0 Fluorescence GdnHCl 8.0 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 4.0 2AFG, 1JQZ 32.451666514078774, 14.473333517710367 25312605 10.1080/09602011.2014.964731 2015 ProTherm 12486 5781 155 C132T Fibroblast growth factor 1 Homo sapiens 1.17 0.35 5.76 4.92 yes 2.0 Sodium phosphate 50mM 25.0 Fluorescence GdnHCl 8.0 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 4.0 2AFG, 1JQZ 32.451666514078774, 14.473333517710367 25312607 10.1111/nph.13026 2014 ProTherm 12487 5782 155 C132V Fibroblast growth factor 1 Homo sapiens 1.23 -0.17 6.28 5.11 yes 2.0 Sodium phosphate 50mM 25.0 Fluorescence GdnHCl 8.0 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 4.0 2AFG, 1JQZ 32.451666514078774, 14.473333517710367 25312608 10.1111/nph.12941 2014 ProTherm 4449 2245 155 K133E Fibroblast growth factor 1 Homo sapiens 60.5 0.9 yes 2.0 39.4 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0 2AFG, 1JQZ 26.467777676052517, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 4455 2245 155 K133E Fibroblast growth factor 1 Homo sapiens 59.6 1.3 yes 2.0 38.5 sodium phosphate 25 mM fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0 2AFG, 1JQZ 26.467777676052517, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 4461 2245 155 K133E Fibroblast growth factor 1 Homo sapiens 55.9 0.4 yes 2.0 40.3 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0 2AFG, 1JQZ 26.467777676052517, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 4467 2245 155 K133E Fibroblast growth factor 1 Homo sapiens 50.8 16.7 yes 2.0 37.4 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0 2AFG, 1JQZ 26.467777676052517, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 4453 2249 155 K133A Fibroblast growth factor 1 Homo sapiens 62.5 0.7 yes 2.0 39.6 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0 2AFG, 1JQZ 26.467777676052517, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 4459 2249 155 K133A Fibroblast growth factor 1 Homo sapiens 59.7 0.8 yes 2.0 39.0 sodium phosphate 25 mM fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0 2AFG, 1JQZ 26.467777676052517, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 4465 2249 155 K133A Fibroblast growth factor 1 Homo sapiens 54.4 3.4 yes 2.0 37.3 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0 2AFG, 1JQZ 26.467777676052517, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 4471 2249 155 K133A Fibroblast growth factor 1 Homo sapiens 53.5 13.4 yes 2.0 40.7 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0 2AFG, 1JQZ 26.467777676052517, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 4454 2250 155 K133N Fibroblast growth factor 1 Homo sapiens 42.0 11.8 yes 2.0 28.5 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0 2AFG, 1JQZ 26.467777676052517, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 4460 2250 155 K133N Fibroblast growth factor 1 Homo sapiens 47.0 11.8 yes 2.0 28.0 sodium phosphate 25 mM fluorescence Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0 2AFG, 1JQZ 26.467777676052517, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 4466 2250 155 K133N Fibroblast growth factor 1 Homo sapiens 49.3 10.8 yes 2.0 29.9 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0 2AFG, 1JQZ 26.467777676052517, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 4472 2250 155 K133N Fibroblast growth factor 1 Homo sapiens 48.4 20.6 yes 2.0 33.5 sodium phosphate 25 mM CD Thermal 7.3 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 7.0 2AFG, 1JQZ 26.467777676052517, 18.286666340298122 in tunnel in pocket 19574212 10.1074/jbc.M109.001289 2009 ProTherm 2659 1348 155 F147W Fibroblast growth factor 1 Homo sapiens 0.29 69.07 1.2 Yes (>80%) 40.95 ADA (N-(2-acetamide)iminodiaceticacid) DSC Thermal 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 9.0 2AFG, 1JQZ 14.910909219221635, 10.41999998959628 in pocket 19695265 10.1016/j.jmb.2009.08.026 2009 ProTherm 10328 1348 155 F147W Fibroblast growth factor 1 Homo sapiens 1.19 0.38 6.24 5.26 Yes (>80%) ADA (N-(2-acetamide)iminodiaceticacid) 25.0 CD, Fluorescence GdnHCl 6.6 P05230 IPR002209:Fibroblast_GF_fam, IPR008996:IL1/FGF 9.0 2AFG, 1JQZ 14.910909219221635, 10.41999998959628 in pocket 19695265 10.1016/j.jmb.2009.08.026 2009 ProTherm 20393 146 345 3-isopropylmalate dehydrogenase Thermus thermophilus 4.51 1.2 yes 3.0 Potassium phosphate 50 mM 27.0 Fluorescence Urea 7.0 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 9930995 10.1021/bi982380v 1999 ProTherm 20394 146 345 3-isopropylmalate dehydrogenase Thermus thermophilus 16.3 1.41 yes 3.0 Potassium phosphate 50 mM 27.0 Fluorescence Urea 7.0 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 9930995 10.1021/bi982380v 1999 ProTherm 22111 146 345 3-isopropylmalate dehydrogenase Thermus thermophilus Unknown 87.0 sodium phosphate ammonium sulfate 1.0-1.5 M CD Thermal 7.0 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 11297665 10.1093/protein/14.2.81 2001 ProTherm 22336 146 345 3-isopropylmalate dehydrogenase Thermus thermophilus Unknown 87.0 phosphate 20 mM CD Thermal 7.0 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 11579229 10.1093/protein/14.8.601 2001 ProTherm 22396 146 345 3-isopropylmalate dehydrogenase Thermus thermophilus 1.73 15.8 yes 30.85 potassium phosphate 50 mM DTT 1 mM Fluorescence Thermal 7.0 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 11809926 10.1093/protein/14.12.961 2001 ProTherm 22464 146 345 3-isopropylmalate dehydrogenase Thermus thermophilus Unknown 87.0 NaHCO3 20 mM CD Thermal 10.4 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 12082165 10.1093/protein/15.6.471 2002 ProTherm 23021 146 345 3-isopropylmalate dehydrogenase Thermus thermophilus No 84.7 potassium phosphate 20 mM Activity Thermal 7.6 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 16309701 10.1016/j.jmb.2005.10.011 2006 ProTherm 23022 146 345 3-isopropylmalate dehydrogenase Thermus thermophilus No 87.4 phosphate 20 mM CD Thermal 7.6 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 16309701 10.1016/j.jmb.2005.10.011 2006 ProTherm 548 306 345 I11V 3-isopropylmalate dehydrogenase Thermus thermophilus 4.0 Unknown 91.0 phosphate 20 mM CD Thermal 7.0 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 9.0 11579229 10.1093/protein/14.8.601 2001 ProTherm 15671 7311 345 I11V, V15I 3-isopropylmalate dehydrogenase Thermus thermophilus 0.0 Unknown 87.0 phosphate 20 mM CD Thermal 7.0 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 9.0, 8.0 11579229 10.1093/protein/14.8.601 2001 ProTherm 15672 7312 345 I11V, S92F 3-isopropylmalate dehydrogenase Thermus thermophilus 4.0 Unknown 91.0 phosphate 20 mM CD Thermal 7.0 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 9.0, 2.0 11579229 10.1093/protein/14.8.601 2001 ProTherm 15676 7316 345 I11V, V15I, S92F 3-isopropylmalate dehydrogenase Thermus thermophilus -2.0 Unknown 85.0 phosphate 20 mM CD Thermal 7.0 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 9.0, 8.0, 2.0 11579229 10.1093/protein/14.8.601 2001 ProTherm 241 129 345 V15I 3-isopropylmalate dehydrogenase Thermus thermophilus Unknown 85.0 sodium phosphate ammonium sulfate 1.0-1.5 M CD Thermal 7.0 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 8.0 11297665 10.1093/protein/14.2.81 2001 ProTherm 549 129 345 V15I 3-isopropylmalate dehydrogenase Thermus thermophilus -2.0 Unknown 85.0 phosphate 20 mM CD Thermal 7.0 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 8.0 11579229 10.1093/protein/14.8.601 2001 ProTherm 15673 7313 345 V15I, S92F 3-isopropylmalate dehydrogenase Thermus thermophilus -4.0 Unknown 83.0 phosphate 20 mM CD Thermal 7.0 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 8.0, 2.0 11579229 10.1093/protein/14.8.601 2001 ProTherm 15674 7314 345 V15I, V126M 3-isopropylmalate dehydrogenase Thermus thermophilus -1.0 Unknown 86.0 phosphate 20 mM CD Thermal 7.0 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 8.0, 6.0 11579229 10.1093/protein/14.8.601 2001 ProTherm 1810 1014 345 T16V 3-isopropylmalate dehydrogenase Thermus thermophilus 0.7 No 85.4 potassium phosphate 20 mM Activity Thermal 7.6 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 5.0 16309701 10.1016/j.jmb.2005.10.011 2006 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, EASE-MM_S1676.csv, PON-TStab_dataset.csv 1822 1014 345 T16V 3-isopropylmalate dehydrogenase Thermus thermophilus 0.8 No 88.2 phosphate 20 mM CD Thermal 7.6 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 5.0 16309701 10.1016/j.jmb.2005.10.011 2006 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, EASE-MM_S1676.csv, M47andM8_S1810.csv 1811 1015 345 F53L 3-isopropylmalate dehydrogenase Thermus thermophilus -1.8 No 82.9 potassium phosphate 20 mM Activity Thermal 7.6 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 6.0 16309701 10.1016/j.jmb.2005.10.011 2006 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, EASE-MM_S1676.csv, HotMuSiC_S1626.csv, PON-TStab_dataset.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 1823 1015 345 F53L 3-isopropylmalate dehydrogenase Thermus thermophilus -1.4 No 86.0 phosphate 20 mM CD Thermal 7.6 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 6.0 16309701 10.1016/j.jmb.2005.10.011 2006 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, HotMuSiC_S1626.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv 1812 1016 345 P56E 3-isopropylmalate dehydrogenase Thermus thermophilus -0.3 No 84.4 potassium phosphate 20 mM Activity Thermal 7.6 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 4.0 16309701 10.1016/j.jmb.2005.10.011 2006 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, HotMuSiC_S1626.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 1824 1016 345 P56E 3-isopropylmalate dehydrogenase Thermus thermophilus 1.3 No 88.7 phosphate 20 mM CD Thermal 7.6 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 4.0 16309701 10.1016/j.jmb.2005.10.011 2006 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, HotMuSiC_S1626.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S499.csv, STRUM_Q3421.csv, PoPMuSiC-2.0_S2648.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 1813 1017 345 R58L 3-isopropylmalate dehydrogenase Thermus thermophilus -1.8 No 82.9 potassium phosphate 20 mM Activity Thermal 7.6 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 5.0 16309701 10.1016/j.jmb.2005.10.011 2006 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, HotMuSiC_S1626.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 1825 1017 345 R58L 3-isopropylmalate dehydrogenase Thermus thermophilus -3.4 No 84.0 phosphate 20 mM CD Thermal 7.6 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 5.0 16309701 10.1016/j.jmb.2005.10.011 2006 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S499.csv 1814 1018 345 V61I 3-isopropylmalate dehydrogenase Thermus thermophilus -0.3 No 84.4 potassium phosphate 20 mM Activity Thermal 7.6 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 6.0 16309701 10.1016/j.jmb.2005.10.011 2006 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, HotMuSiC_S1626.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 1826 1018 345 V61I 3-isopropylmalate dehydrogenase Thermus thermophilus -0.2 No 87.2 phosphate 20 mM CD Thermal 7.6 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 6.0 16309701 10.1016/j.jmb.2005.10.011 2006 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S499.csv 243 131 345 S92F 3-isopropylmalate dehydrogenase Thermus thermophilus Unknown 87.0 sodium phosphate ammonium sulfate 1.0-1.5 M CD Thermal 7.0 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 2.0 11297665 10.1093/protein/14.2.81 2001 ProTherm 550 131 345 S92F 3-isopropylmalate dehydrogenase Thermus thermophilus 0.0 Unknown 87.0 phosphate 20 mM CD Thermal 7.0 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 2.0 11579229 10.1093/protein/14.8.601 2001 ProTherm M47andM8_S2760.csv 15675 7315 345 S92F, V126M 3-isopropylmalate dehydrogenase Thermus thermophilus 0.0 Unknown 87.0 phosphate 20 mM CD Thermal 7.0 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 2.0, 6.0 11579229 10.1093/protein/14.8.601 2001 ProTherm 242 130 345 V126M 3-isopropylmalate dehydrogenase Thermus thermophilus Unknown 87.0 sodium phosphate ammonium sulfate 1.0-1.5 M CD Thermal 7.0 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 6.0 11297665 10.1093/protein/14.2.81 2001 ProTherm 551 130 345 V126M 3-isopropylmalate dehydrogenase Thermus thermophilus 0.0 Unknown 87.0 phosphate 20 mM CD Thermal 7.0 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 6.0 11579229 10.1093/protein/14.8.601 2001 ProTherm 1237 130 345 V126M 3-isopropylmalate dehydrogenase Thermus thermophilus 0.0 Unknown 87.0 NaHCO3 20 mM CD Thermal 10.4 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 6.0 12082165 10.1093/protein/15.6.471 2002 ProTherm 1233 708 345 V126G 3-isopropylmalate dehydrogenase Thermus thermophilus -5.0 Unknown 82.0 NaHCO3 20 mM CD Thermal 10.4 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 6.0 12082165 10.1093/protein/15.6.471 2002 ProTherm 1234 709 345 V126A 3-isopropylmalate dehydrogenase Thermus thermophilus -2.0 Unknown 85.0 NaHCO3 20 mM CD Thermal 10.4 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 6.0 12082165 10.1093/protein/15.6.471 2002 ProTherm 1235 710 345 V126S 3-isopropylmalate dehydrogenase Thermus thermophilus -13.0 Unknown 74.0 NaHCO3 20 mM CD Thermal 10.4 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 6.0 12082165 10.1093/protein/15.6.471 2002 ProTherm 1236 711 345 V126E 3-isopropylmalate dehydrogenase Thermus thermophilus -10.0 Unknown 77.0 NaHCO3 20 mM CD Thermal 10.4 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 6.0 12082165 10.1093/protein/15.6.471 2002 ProTherm 1238 712 345 V126L 3-isopropylmalate dehydrogenase Thermus thermophilus -5.0 Unknown 82.0 NaHCO3 20 mM CD Thermal 10.4 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 6.0 12082165 10.1093/protein/15.6.471 2002 ProTherm 1239 713 345 V126I 3-isopropylmalate dehydrogenase Thermus thermophilus -5.0 Unknown 82.0 NaHCO3 20 mM CD Thermal 10.4 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 6.0 12082165 10.1093/protein/15.6.471 2002 ProTherm 1240 714 345 V126F 3-isopropylmalate dehydrogenase Thermus thermophilus -7.0 Unknown 80.0 NaHCO3 20 mM CD Thermal 10.4 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 6.0 12082165 10.1093/protein/15.6.471 2002 ProTherm 1815 1019 345 L134N 3-isopropylmalate dehydrogenase Thermus thermophilus 3.2 No 87.9 potassium phosphate 20 mM Activity Thermal 7.6 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 9.0 16309701 10.1016/j.jmb.2005.10.011 2006 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, STRUM_Q306.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 1827 1019 345 L134N 3-isopropylmalate dehydrogenase Thermus thermophilus 3.9 No 91.3 phosphate 20 mM CD Thermal 7.6 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 9.0 16309701 10.1016/j.jmb.2005.10.011 2006 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, STRUM_Q3421.csv 16021 7526 345 L134N, V181T, P324T, A335E 3-isopropylmalate dehydrogenase Thermus thermophilus 5.5 Unknown 90.2 potassium phosphate 20 mM Activity Thermal 7.6 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 9.0, 8.0, 8.0, 4.0 16797545 10.1016/j.febslet.2006.06.012 2006 ProTherm 16023 7526 345 L134N, V181T, P324T, A335E 3-isopropylmalate dehydrogenase Thermus thermophilus 5.3 Unknown 92.7 phosphate 20 mM CD Thermal 7.6 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 9.0, 8.0, 8.0, 4.0 16797545 10.1016/j.febslet.2006.06.012 2006 ProTherm 1816 1020 345 H179K 3-isopropylmalate dehydrogenase Thermus thermophilus -1.8 No 82.9 potassium phosphate 20 mM Activity Thermal 7.6 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 4.0 16309701 10.1016/j.jmb.2005.10.011 2006 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, STRUM_Q306.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, HotMuSiC_S1626.csv, M47andM8_S1810.csv 1828 1020 345 H179K 3-isopropylmalate dehydrogenase Thermus thermophilus -0.3 No 87.1 phosphate 20 mM CD Thermal 7.6 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 4.0 16309701 10.1016/j.jmb.2005.10.011 2006 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, STRUM_Q3421.csv, EASE-MM_S1676.csv 1817 1021 345 V181T 3-isopropylmalate dehydrogenase Thermus thermophilus 1.4 No 86.1 potassium phosphate 20 mM Activity Thermal 7.6 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 8.0 16309701 10.1016/j.jmb.2005.10.011 2006 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, HotMuSiC_S1626.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 1829 1021 345 V181T 3-isopropylmalate dehydrogenase Thermus thermophilus 1.7 No 89.1 phosphate 20 mM CD Thermal 7.6 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 8.0 16309701 10.1016/j.jmb.2005.10.011 2006 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, EASE-MM_S1676.csv, PON-TStab_dataset.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S499.csv 16020 7525 345 V181T, P324T, A335E 3-isopropylmalate dehydrogenase Thermus thermophilus 3.4 Unknown 88.1 potassium phosphate 20 mM Activity Thermal 7.6 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 8.0, 8.0, 4.0 16797545 10.1016/j.febslet.2006.06.012 2006 ProTherm 16022 7525 345 V181T, P324T, A335E 3-isopropylmalate dehydrogenase Thermus thermophilus 3.5 Unknown 90.9 phosphate 20 mM CD Thermal 7.6 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 8.0, 8.0, 4.0 16797545 10.1016/j.febslet.2006.06.012 2006 ProTherm 1818 1022 345 D184H 3-isopropylmalate dehydrogenase Thermus thermophilus 0.1 No 84.8 potassium phosphate 20 mM Activity Thermal 7.6 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 9.0 16309701 10.1016/j.jmb.2005.10.011 2006 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, HotMuSiC_S1626.csv 1830 1022 345 D184H 3-isopropylmalate dehydrogenase Thermus thermophilus 1.4 No 88.8 phosphate 20 mM CD Thermal 7.6 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 9.0 16309701 10.1016/j.jmb.2005.10.011 2006 ProTherm EASE-MM_S1676.csv, HotMuSiC_S1626.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S499.csv 1819 1023 345 S261N 3-isopropylmalate dehydrogenase Thermus thermophilus -1.4 No 83.3 potassium phosphate 20 mM Activity Thermal 7.6 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 9.0 16309701 10.1016/j.jmb.2005.10.011 2006 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, HotMuSiC_S1626.csv 1831 1023 345 S261N 3-isopropylmalate dehydrogenase Thermus thermophilus -1.8 No 85.6 phosphate 20 mM CD Thermal 7.6 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 9.0 16309701 10.1016/j.jmb.2005.10.011 2006 ProTherm EASE-MM_S1676.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S499.csv 1820 1024 345 P324T 3-isopropylmalate dehydrogenase Thermus thermophilus 0.7 No 85.4 potassium phosphate 20 mM Activity Thermal 7.6 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 8.0 16309701 10.1016/j.jmb.2005.10.011 2006 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, HotMuSiC_S1626.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S499.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 1832 1024 345 P324T 3-isopropylmalate dehydrogenase Thermus thermophilus 0.3 No 87.7 phosphate 20 mM CD Thermal 7.6 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 8.0 16309701 10.1016/j.jmb.2005.10.011 2006 ProTherm EASE-MM_S1676.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S499.csv 1821 1025 345 A335E 3-isopropylmalate dehydrogenase Thermus thermophilus 0.4 No 85.1 potassium phosphate 20 mM Activity Thermal 7.6 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 4.0 16309701 10.1016/j.jmb.2005.10.011 2006 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, EASE-MM_S1676.csv 1833 1025 345 A335E 3-isopropylmalate dehydrogenase Thermus thermophilus 0.9 No 88.3 phosphate 20 mM CD Thermal 7.6 1.1.1.85 P61495 IPR019818:IsoCit/isopropylmalate_DH_CS, IPR024084:IsoPropMal-DH-like_dom, IPR004429:Isopropylmalate_DH 4.0 16309701 10.1016/j.jmb.2005.10.011 2006 ProTherm M47andM8_S1810.csv, M47andM8_S2760.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S499.csv, EASE-MM_S1676.csv, PON-TStab_dataset.csv 17850 154 278 Chitosanase Streptomyces sp. (strain N174) 120.0 yes(85%) 3.0 42.7 sodium phosphate 50 mM CD Thermal 7.0 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 9989221 10.1016/s0167-4838(98)00243-x 1999 ProTherm 17851 154 278 Chitosanase Streptomyces sp. (strain N174) 130.0 yes(85%) 3.0 52.2 sodium phosphate 50 mM CD Thermal 7.0 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 9989221 10.1016/s0167-4838(98)00243-x 1999 ProTherm 17852 154 278 Chitosanase Streptomyces sp. (strain N174) 160.6 yes(75%) 43.2 sodium phosphate 50 mM Fluorescence Thermal 7.0 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 9989221 10.1016/s0167-4838(98)00243-x 1999 ProTherm 23733 154 278 Chitosanase Streptomyces sp. (strain N174) No 53.5 Sodium acetate 50 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23734 154 278 Chitosanase Streptomyces sp. (strain N174) No 53.7 Sodium phosphate 50 mM Fluorescence Thermal 4.75 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23735 154 278 Chitosanase Streptomyces sp. (strain N174) No 41.3 Sodium phosphate 50 mM Fluorescence Thermal 7.0 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23736 154 278 Chitosanase Streptomyces sp. (strain N174) No 54.0 Sodium acetate 50 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23737 154 278 Chitosanase Streptomyces sp. (strain N174) No 54.0 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23738 154 278 Chitosanase Streptomyces sp. (strain N174) No 54.9 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23739 154 278 Chitosanase Streptomyces sp. (strain N174) No 57.2 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23740 154 278 Chitosanase Streptomyces sp. (strain N174) No 60.0 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23741 154 278 Chitosanase Streptomyces sp. (strain N174) No 64.6 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23742 154 278 Chitosanase Streptomyces sp. (strain N174) No 66.7 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23743 154 278 Chitosanase Streptomyces sp. (strain N174) No 67.9 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23744 154 278 Chitosanase Streptomyces sp. (strain N174) No 68.0 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23745 154 278 Chitosanase Streptomyces sp. (strain N174) No 69.5 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23746 154 278 Chitosanase Streptomyces sp. (strain N174) No 54.6 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23747 154 278 Chitosanase Streptomyces sp. (strain N174) No 55.3 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23748 154 278 Chitosanase Streptomyces sp. (strain N174) No 56.3 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23749 154 278 Chitosanase Streptomyces sp. (strain N174) No 58.5 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23750 154 278 Chitosanase Streptomyces sp. (strain N174) No 60.7 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23751 154 278 Chitosanase Streptomyces sp. (strain N174) No 61.6 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23752 154 278 Chitosanase Streptomyces sp. (strain N174) No 62.9 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23753 154 278 Chitosanase Streptomyces sp. (strain N174) No 65.7 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23754 154 278 Chitosanase Streptomyces sp. (strain N174) No 66.2 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23755 154 278 Chitosanase Streptomyces sp. (strain N174) No 44.4 Sodium acetate 150 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23756 154 278 Chitosanase Streptomyces sp. (strain N174) No 52.4 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23757 154 278 Chitosanase Streptomyces sp. (strain N174) No 58.3 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23758 154 278 Chitosanase Streptomyces sp. (strain N174) No 58.9 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23759 154 278 Chitosanase Streptomyces sp. (strain N174) No 57.1 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23760 154 278 Chitosanase Streptomyces sp. (strain N174) No 55.4 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23761 154 278 Chitosanase Streptomyces sp. (strain N174) No 59.2 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23762 154 278 Chitosanase Streptomyces sp. (strain N174) No 59.4 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23763 154 278 Chitosanase Streptomyces sp. (strain N174) No 58.7 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23764 154 278 Chitosanase Streptomyces sp. (strain N174) No 58.1 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23765 154 278 Chitosanase Streptomyces sp. (strain N174) No 57.0 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23766 154 278 Chitosanase Streptomyces sp. (strain N174) No 64.4 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23767 154 278 Chitosanase Streptomyces sp. (strain N174) No 59.7 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23768 154 278 Chitosanase Streptomyces sp. (strain N174) No 54.2 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23769 154 278 Chitosanase Streptomyces sp. (strain N174) No 55.1 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23770 154 278 Chitosanase Streptomyces sp. (strain N174) No 55.5 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23771 154 278 Chitosanase Streptomyces sp. (strain N174) No 56.8 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23772 154 278 Chitosanase Streptomyces sp. (strain N174) No 53.5 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23773 154 278 Chitosanase Streptomyces sp. (strain N174) No 47.5 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23774 154 278 Chitosanase Streptomyces sp. (strain N174) No 51.4 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23775 154 278 Chitosanase Streptomyces sp. (strain N174) No 70.1 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23776 154 278 Chitosanase Streptomyces sp. (strain N174) No 68.6 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23777 154 278 Chitosanase Streptomyces sp. (strain N174) No 67.4 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23778 154 278 Chitosanase Streptomyces sp. (strain N174) No 69.6 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 23779 154 278 Chitosanase Streptomyces sp. (strain N174) No 66.6 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 254 136 278 W68F Chitosanase Streptomyces sp. (strain N174) 155.0 -7.1 yes(77%) 3.0 35.6 sodium phosphate 50 mM CD Thermal 7.0 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 9.0 1CHK 8.62071430683136 in pocket 9989221 10.1016/s0167-4838(98)00243-x 1999 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 257 136 278 W68F Chitosanase Streptomyces sp. (strain N174) 80.0 -7.0 yes(77%) 3.0 45.2 sodium phosphate 50 mM CD Thermal 7.0 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 9.0 1CHK 8.62071430683136 in pocket 9989221 10.1016/s0167-4838(98)00243-x 1999 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 260 136 278 W68F Chitosanase Streptomyces sp. (strain N174) 196.5 -7.0 yes(75%) 36.2 sodium phosphate 50 mM Fluorescence Thermal 7.0 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 9.0 1CHK 8.62071430683136 in pocket 9989221 10.1016/s0167-4838(98)00243-x 1999 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7459 136 278 W68F Chitosanase Streptomyces sp. (strain N174) 1.76 yes(77%) 3.0 sodium phosphate 50 mM 52.2 CD Thermal 7.0 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 9.0 1CHK 8.62071430683136 in pocket 9989221 10.1016/s0167-4838(98)00243-x 1999 ProTherm 8008 136 278 W68F Chitosanase Streptomyces sp. (strain N174) 4.43 yes(75%) sodium phosphate 50 mM 43.2 Fluorescence Thermal 7.0 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 9.0 1CHK 8.62071430683136 in pocket 9989221 10.1016/s0167-4838(98)00243-x 1999 ProTherm 8010 136 278 W68F Chitosanase Streptomyces sp. (strain N174) 3.56 yes(77%) 3.0 sodium phosphate 50 mM 42.7 CD Thermal 7.0 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 9.0 1CHK 8.62071430683136 in pocket 9989221 10.1016/s0167-4838(98)00243-x 1999 ProTherm 14468 6714 278 W68F, W141F Chitosanase Streptomyces sp. (strain N174) 155.0 -11.4 yes(68%) 3.0 31.3 sodium phosphate 50 mM CD Thermal 7.0 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 9.0, 9.0 1CHK 8.62071430683136, 12.32714285169329 in pocket 9989221 10.1016/s0167-4838(98)00243-x 1999 ProTherm 14469 6714 278 W68F, W141F Chitosanase Streptomyces sp. (strain N174) 60.0 -8.0 yes(68%) 3.0 44.2 sodium phosphate 50 mM CD Thermal 7.0 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 9.0, 9.0 1CHK 8.62071430683136, 12.32714285169329 in pocket 9989221 10.1016/s0167-4838(98)00243-x 1999 ProTherm 14470 6714 278 W68F, W141F Chitosanase Streptomyces sp. (strain N174) 203.6 -12.0 yes(80%) 31.2 sodium phosphate 50 mM Fluorescence Thermal 7.0 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 9.0, 9.0 1CHK 8.62071430683136, 12.32714285169329 in pocket 9989221 10.1016/s0167-4838(98)00243-x 1999 ProTherm 14996 6714 278 W68F, W141F Chitosanase Streptomyces sp. (strain N174) 1.51 yes(68%) 3.0 sodium phosphate 50 mM 52.2 CD Thermal 7.0 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 9.0, 9.0 1CHK 8.62071430683136, 12.32714285169329 in pocket 9989221 10.1016/s0167-4838(98)00243-x 1999 ProTherm 15095 6714 278 W68F, W141F Chitosanase Streptomyces sp. (strain N174) 8.03 yes(80%) sodium phosphate 50 mM 43.2 Fluorescence Thermal 7.0 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 9.0, 9.0 1CHK 8.62071430683136, 12.32714285169329 in pocket 9989221 10.1016/s0167-4838(98)00243-x 1999 ProTherm 15096 6714 278 W68F, W141F Chitosanase Streptomyces sp. (strain N174) 5.8 yes(68%) 3.0 sodium phosphate 50 mM 42.7 CD Thermal 7.0 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 9.0, 9.0 1CHK 8.62071430683136, 12.32714285169329 in pocket 9989221 10.1016/s0167-4838(98)00243-x 1999 ProTherm 255 137 278 W141F Chitosanase Streptomyces sp. (strain N174) 170.0 -7.1 yes(79%) 3.0 35.6 sodium phosphate 50 mM CD Thermal 7.0 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 9.0 1CHK 12.32714285169329 9989221 10.1016/s0167-4838(98)00243-x 1999 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 258 137 278 W141F Chitosanase Streptomyces sp. (strain N174) 80.0 -7.5 yes(79%) 3.0 44.7 sodium phosphate 50 mM CD Thermal 7.0 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 9.0 1CHK 12.32714285169329 9989221 10.1016/s0167-4838(98)00243-x 1999 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 261 137 278 W141F Chitosanase Streptomyces sp. (strain N174) 200.4 -6.6 yes(77%) 36.6 sodium phosphate 50 mM Fluorescence Thermal 7.0 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 9.0 1CHK 12.32714285169329 9989221 10.1016/s0167-4838(98)00243-x 1999 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7460 137 278 W141F Chitosanase Streptomyces sp. (strain N174) 1.89 yes(79%) 3.0 sodium phosphate 50 mM 52.2 CD Thermal 7.0 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 9.0 1CHK 12.32714285169329 9989221 10.1016/s0167-4838(98)00243-x 1999 ProTherm khan_protherm_data_mapped.csv 8007 137 278 W141F Chitosanase Streptomyces sp. (strain N174) 4.27 yes(77%) sodium phosphate 50 mM 43.2 Fluorescence Thermal 7.0 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 9.0 1CHK 12.32714285169329 9989221 10.1016/s0167-4838(98)00243-x 1999 ProTherm 8011 137 278 W141F Chitosanase Streptomyces sp. (strain N174) 3.91 yes(79%) 3.0 sodium phosphate 50 mM 42.7 CD Thermal 7.0 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 9.0 1CHK 12.32714285169329 9989221 10.1016/s0167-4838(98)00243-x 1999 ProTherm 2644 1344 278 A144L Chitosanase Streptomyces sp. (strain N174) -5.5 No 48.0 Sodium acetate 50 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 9.0 1CHK 8.858000135421753 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 2645 1344 278 A144L Chitosanase Streptomyces sp. (strain N174) -5.3 No 48.7 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 9.0 1CHK 8.858000135421753 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 2646 1344 278 A144L Chitosanase Streptomyces sp. (strain N174) -5.3 No 50.2 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 9.0 1CHK 8.858000135421753 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 2647 1344 278 A144L Chitosanase Streptomyces sp. (strain N174) No 59.0 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 9.0 1CHK 8.858000135421753 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm STRUM_Q306.csv, STRUM_Q3421.csv 2648 1344 278 A144L Chitosanase Streptomyces sp. (strain N174) -6.2 No 60.5 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 9.0 1CHK 8.858000135421753 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 2649 1344 278 A144L Chitosanase Streptomyces sp. (strain N174) -7.0 No 62.5 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 9.0 1CHK 8.858000135421753 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 2650 1345 278 K204R Chitosanase Streptomyces sp. (strain N174) -1.0 No 53.0 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 3.0 1CHK 29.173332850138348 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 2651 1345 278 K204R Chitosanase Streptomyces sp. (strain N174) -0.2 No 54.7 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 3.0 1CHK 29.173332850138348 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 2652 1345 278 K204R Chitosanase Streptomyces sp. (strain N174) No 63.2 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 3.0 1CHK 29.173332850138348 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 2653 1345 278 K204R Chitosanase Streptomyces sp. (strain N174) -0.2 No 66.5 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 3.0 1CHK 29.173332850138348 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 2654 1345 278 K204R Chitosanase Streptomyces sp. (strain N174) -0.9 No 68.6 Sodium acetate 100 mM Fluorescence Thermal 4.5 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 3.0 1CHK 29.173332850138348 17644457 10.1016/j.bbapap.2007.05.016 2007 ProTherm 256 138 278 W267F Chitosanase Streptomyces sp. (strain N174) 135.0 -6.8 yes(79%) 3.0 35.9 sodium phosphate 50 mM CD Thermal 7.0 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 9.0 1CHK 19.782857213701522 in pocket 9989221 10.1016/s0167-4838(98)00243-x 1999 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 259 138 278 W267F Chitosanase Streptomyces sp. (strain N174) 65.0 -6.4 yes(79%) 3.0 45.8 sodium phosphate 50 mM CD Thermal 7.0 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 9.0 1CHK 19.782857213701522 in pocket 9989221 10.1016/s0167-4838(98)00243-x 1999 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 262 138 278 W267F Chitosanase Streptomyces sp. (strain N174) 131.9 -5.9 yes(81%) 37.3 sodium phosphate 50 mM Fluorescence Thermal 7.0 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 9.0 1CHK 19.782857213701522 in pocket 9989221 10.1016/s0167-4838(98)00243-x 1999 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7461 138 278 W267F Chitosanase Streptomyces sp. (strain N174) 1.31 yes(79%) 3.0 sodium phosphate 50 mM 52.2 CD Thermal 7.0 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 9.0 1CHK 19.782857213701522 in pocket 9989221 10.1016/s0167-4838(98)00243-x 1999 ProTherm khan_protherm_data_mapped.csv 8009 138 278 W267F Chitosanase Streptomyces sp. (strain N174) 2.51 yes(81%) sodium phosphate 50 mM 43.2 Fluorescence Thermal 7.0 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 9.0 1CHK 19.782857213701522 in pocket 9989221 10.1016/s0167-4838(98)00243-x 1999 ProTherm 8012 138 278 W267F Chitosanase Streptomyces sp. (strain N174) 2.97 yes(79%) 3.0 sodium phosphate 50 mM 42.7 CD Thermal 7.0 3.2.1.132 P33665 IPR000400:Glyco_hydro_46, IPR023099:Glyco_hydro_46_N, IPR023346:Lysozyme-like_dom_sf 9.0 1CHK 19.782857213701522 in pocket 9989221 10.1016/s0167-4838(98)00243-x 1999 ProTherm 19786 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.33 62.14 63.34 yes 57.2 sodium phosphate 20 mM DSC Thermal 6.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8819170 10.1002/pro.5560050716 1996 ProTherm 19787 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.33 62.62 61.9 yes 57.3 phosphate 50 mM DSC Thermal 6.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8819170 10.1002/pro.5560050716 1996 ProTherm 19788 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.36 63.1 65.06 yes 57.4 phosphate 20 mM DSC Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8819170 10.1002/pro.5560050716 1996 ProTherm 19789 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.36 63.34 62.09 yes 57.3 phosphate 50 mM DSC Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8819170 10.1002/pro.5560050716 1996 ProTherm 19790 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.31 63.1 65.05 yes 57.3 phosphate 20 mM DSC Thermal 8.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8819170 10.1002/pro.5560050716 1996 ProTherm 19791 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.31 63.58 64.05 yes 57.3 phosphate 50 mM DSC Thermal 8.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8819170 10.1002/pro.5560050716 1996 ProTherm 19792 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.37 64.05 66.03 yes 57.3 phosphate 50 mM DSC Thermal 9.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8819170 10.1002/pro.5560050716 1996 ProTherm 19793 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.39 53.54 50.04 yes 48.9 glycine 50 mM DSC Thermal 10.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8819170 10.1002/pro.5560050716 1996 ProTherm 19794 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 49.24 no 40.3 glycine 50 mM DSC Thermal 11.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8819170 10.1002/pro.5560050716 1996 ProTherm 21025 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 2.41 Unknown MES 375 mM 25.0 Fluorescence Urea 6.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 10388575 10.1006/jmbi.1999.2863 1999 ProTherm 21026 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.78 Unknown Tris 583 mM 25.0 Fluorescence Urea 8.5 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 10388575 10.1006/jmbi.1999.2863 1999 ProTherm 21241 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 2.8 6.3 2.3 Unknown Tris-HCl 20 mM 25.0 NaCl 40 mM CD GdnHCl 7.5 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7773177 10.1002/pro.5560040108 1995 ProTherm 21242 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 2.3 4.5 2.0 Unknown Tris-HCl 20 mM 25.0 NaCl 40 mM CD GdnHCl 7.5 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7773177 10.1002/pro.5560040108 1995 ProTherm 21359 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 4.09 yes sodium phosphate 20 mM 25.0 DSC Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8819170 10.1002/pro.5560050716 1996 ProTherm 21360 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.39 3.9 17.95 yes Sodium phosphate 50 mM 25.0 DSC Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8819170 10.1002/pro.5560050716 1996 ProTherm 22430 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) yes 3.0 45.75 MOPS 1 mM NaCl 0.5 M Fluorescence Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 11967382 10.1110/ps.2980102 2002 ProTherm 22431 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) yes 3.0 44.15 MOPS 1 mM Chol Cl 0.5 M Fluorescence Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 11967382 10.1110/ps.2980102 2002 ProTherm 22432 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) yes 3.0 37.35 MOPS 1 mM Fluorescence Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 11967382 10.1110/ps.2980102 2002 ProTherm 22433 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) yes 3.0 58.95 MOPS 1 mM Fluorescence Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 11967382 10.1110/ps.2980102 2002 ProTherm 22434 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) yes 3.0 54.45 MOPS 1 mM Chol Cl 0.5 M Fluorescence Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 11967382 10.1110/ps.2980102 2002 ProTherm 22435 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) yes 3.0 61.45 MOPS 1 mM NaCl 0.5 M Fluorescence Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 11967382 10.1110/ps.2980102 2002 ProTherm 22974 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 33.9 Yes 3.0 44.15 MOPS 50 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 22975 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 52.7 Yes 3.0 55.85 MOPS 50 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 22976 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 28.0 Yes 3.0 38.85 MOPS 50 mM DSC Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 22977 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 60.0 Yes 3.0 52.85 MOPS 50 mM DSC Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 22978 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 33.9 yes 3.0 44.15 MOPS 50 mM NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 22979 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 52.7 yes 3.0 55.85 MOPS 50 mM NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 23223 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 17.2 Yes 43.25 Mops 50 mM NaCl 0.5 M Fluorescence, CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm 23352 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 34.1 Yes 3.0 44.15 Mops 5-50 mM NaCl 15 mM Abs, CD, Fluorescence Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 16563433 10.1016/j.jmb.2006.02.060 2006 ProTherm 23353 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 52.9 Yes 3.0 55.85 Mops 5-50 mM NaCl 15 mM Abs, CD, Fluorescence Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 16563433 10.1016/j.jmb.2006.02.060 2006 ProTherm 25530 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.65 Yes Mops 50 mM 25.2 NaCl 0.5 M Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm 25732 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.59 3.58 2.25 yes MOPS 1 mM 25.0 Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 11967382 10.1110/ps.2980102 2002 ProTherm 25733 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 2.18 4.91 2.25 yes MOPS 1 mM 25.0 Chol Cl 0.50 M Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 11967382 10.1110/ps.2980102 2002 ProTherm 25734 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 3.28 7.38 2.25 yes MOPS 1 mM 25.0 NaCl 0.50 M Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 11967382 10.1110/ps.2980102 2002 ProTherm 25735 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 2.87 6.46 2.25 yes MOPS 1 mM 25.0 KCl 0.50 M Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 11967382 10.1110/ps.2980102 2002 ProTherm 25736 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 2.84 6.39 2.25 yes MOPS 1 mM 25.0 MgCl2 0.16 M Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 11967382 10.1110/ps.2980102 2002 ProTherm 25737 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 2.71 6.1 2.25 yes MOPS 1 mM 25.0 CaCl2 0.16 M Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 11967382 10.1110/ps.2980102 2002 ProTherm 26022 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 2.07 2.44 Yes MOPS 50 mM 25.0 Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 26023 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 2.07 2.44 yes MOPS 50 mM 25.0 NaCl 15 mM CD Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 26404 158 170 Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 2.07 2.44 Yes Mops 50 mM 25.0 Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 16563433 10.1016/j.jmb.2006.02.060 2006 ProTherm 1659 923 170 L7A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 28.7 -11.8 yes 3.0 32.35 MOPS 50 mM NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0 1FTG, 1FLV 9.392499923706055, 7.4362499713897705 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 1677 923 170 L7A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 23.8 -9.9 yes 3.0 45.95 MOPS 50 mM NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0 1FTG, 1FLV 9.392499923706055, 7.4362499713897705 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 7922 923 170 L7A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.11 yes 3.0 MOPS 50 mM 44.3 NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0 1FTG, 1FLV 9.392499923706055, 7.4362499713897705 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm khan_protherm_data_mapped.csv 7940 923 170 L7A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.74 yes 3.0 MOPS 50 mM 44.3 NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0 1FTG, 1FLV 9.392499923706055, 7.4362499713897705 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 9318 923 170 L7A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.78 3.53 1.96 yes MOPS 50 mM 25.0 NaCl 15 mM CD Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0 1FTG, 1FLV 9.392499923706055, 7.4362499713897705 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 10977 4672 170 F8L Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 2.39 0.04 Unknown MES 375 mM 25.0 Fluorescence Urea 6.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0 1FTG, 1FLV 6.8045454892245205, 6.128181804310191 in pocket 10388575 10.1006/jmbi.1999.2863 1999 ProTherm SAAFEC_S1262.csv 10980 4672 170 F8L Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.87 -0.23 Unknown Tris 583 mM 25.0 Fluorescence Urea 8.5 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0 1FTG, 1FLV 6.8045454892245205, 6.128181804310191 in pocket 10388575 10.1006/jmbi.1999.2863 1999 ProTherm 15381 7141 170 H35A, F8L Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 2.05 0.71 Unknown MES 375 mM 25.0 Fluorescence Urea 6.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0, 3.0 1FTG, 1FLV 6.8045454892245205, 9.37999997138977, 6.128181804310191, 9.950000047683716 in pocket 10388575 10.1006/jmbi.1999.2863 1999 ProTherm 15383 7141 170 H35A, F8L Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.15 1.64 Unknown Tris 583 mM 25.0 Fluorescence Urea 8.5 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0, 3.0 1FTG, 1FLV 6.8045454892245205, 9.37999997138977, 6.128181804310191, 9.950000047683716 in pocket 10388575 10.1006/jmbi.1999.2863 1999 ProTherm 1982 1105 170 V19I Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 13.6 4.9 Yes 48.15 Mops 50 mM NaCl 0.5 M Fluorescence, CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 6.0 1FTG, 1FLV 15.765714236668178, 11.524285588945661 in pocket 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, M47andM8_S1810.csv 2357 1105 170 V19I Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 35.9 0.7 Yes 3.0 44.85 Mops 5-50 mM NaCl 15 mM Abs, CD, Fluorescence Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 6.0 1FTG, 1FLV 15.765714236668178, 11.524285588945661 in pocket 16563433 10.1016/j.jmb.2006.02.060 2006 ProTherm AUTOMUTE_S1962.csv, Broom_S605.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 2360 1105 170 V19I Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 59.0 1.3 Yes 3.0 57.15 Mops 5-50 mM NaCl 15 mM Abs, CD, Fluorescence Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 6.0 1FTG, 1FLV 15.765714236668178, 11.524285588945661 in pocket 16563433 10.1016/j.jmb.2006.02.060 2006 ProTherm 7958 1105 170 V19I Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) -0.08 Yes 3.0 Mops 5-50 mM 44.3 NaCl 15 mM Abs, CD, Fluorescence Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 6.0 1FTG, 1FLV 15.765714236668178, 11.524285588945661 in pocket 16563433 10.1016/j.jmb.2006.02.060 2006 ProTherm khan_protherm_data_mapped.csv 7961 1105 170 V19I Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) -0.44 Yes 3.0 Mops 5-50 mM 44.3 NaCl 15 mM Abs, CD, Fluorescence Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 6.0 1FTG, 1FLV 15.765714236668178, 11.524285588945661 in pocket 16563433 10.1016/j.jmb.2006.02.060 2006 ProTherm 7963 1105 170 V19I Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) -0.52 Yes Mops 5-50 mM 44.3 NaCl 15 mM Abs, CD, Fluorescence Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 6.0 1FTG, 1FLV 15.765714236668178, 11.524285588945661 in pocket 16563433 10.1016/j.jmb.2006.02.060 2006 ProTherm 7993 1105 170 V19I Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.34 -0.19 Yes Mops 50 mM 43.4 NaCl 0.5 M Fluorescence, CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 6.0 1FTG, 1FLV 15.765714236668178, 11.524285588945661 in pocket 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm khan_protherm_data_mapped.csv 8478 1105 170 V19I Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.04 -0.27 Yes Mops 50 mM 25.2 NaCl 0.5 M Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 6.0 1FTG, 1FLV 15.765714236668178, 11.524285588945661 in pocket 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm 9926 1105 170 V19I Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 2.35 -1.03 2.59 Yes Mops 50 mM 25.0 Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 6.0 1FTG, 1FLV 15.765714236668178, 11.524285588945661 in pocket 16563433 10.1016/j.jmb.2006.02.060 2006 ProTherm SAAFEC_S1262.csv 2358 1200 170 V19L Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 36.8 0.4 Yes 3.0 44.55 Mops 5-50 mM NaCl 15 mM Abs, CD, Fluorescence Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 6.0 1FTG, 1FLV 15.765714236668178, 11.524285588945661 in pocket 16563433 10.1016/j.jmb.2006.02.060 2006 ProTherm AUTOMUTE_S1925.csv, HotMuSiC_S1626.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, STRUM_Q306.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, EASE-MM_S1676.csv, AUTOMUTE_S1962.csv, Broom_S605.csv, Saraboji_S2204.csv, SVM-WIN31_SVM-3D12_S1681.csv 2361 1200 170 V19L Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 52.0 0.5 Yes 3.0 56.35 Mops 5-50 mM NaCl 15 mM Abs, CD, Fluorescence Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 6.0 1FTG, 1FLV 15.765714236668178, 11.524285588945661 in pocket 16563433 10.1016/j.jmb.2006.02.060 2006 ProTherm Broom_S605.csv, EASE-MM_S543.csv, PoPMuSiC-2.0_S2648.csv 7959 1200 170 V19L Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) -0.04 Yes 3.0 Mops 5-50 mM 44.3 NaCl 15 mM Abs, CD, Fluorescence Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 6.0 1FTG, 1FLV 15.765714236668178, 11.524285588945661 in pocket 16563433 10.1016/j.jmb.2006.02.060 2006 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 7964 1200 170 V19L Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) -0.09 Yes Mops 5-50 mM 44.3 NaCl 15 mM Abs, CD, Fluorescence Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 6.0 1FTG, 1FLV 15.765714236668178, 11.524285588945661 in pocket 16563433 10.1016/j.jmb.2006.02.060 2006 ProTherm potapov_with_uniprot_mapping.csv 9927 1200 170 V19L Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 2.15 -0.6 2.63 Yes Mops 50 mM 25.0 Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 6.0 1FTG, 1FLV 15.765714236668178, 11.524285588945661 in pocket 16563433 10.1016/j.jmb.2006.02.060 2006 ProTherm SAAFEC_S1262.csv 1632 916 170 E21K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 30.2 -1.5 Yes 3.0 42.65 MOPS 50 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 4.0 1FTG, 1FLV 14.061111026340061, 13.239999930063883 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 1640 916 170 E21K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 66.1 3.8 Yes 3.0 59.65 MOPS 50 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 4.0 1FTG, 1FLV 14.061111026340061, 13.239999930063883 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 1648 916 170 E21K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 22.0 -2.7 Yes 3.0 36.15 MOPS 50 mM DSC Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 4.0 1FTG, 1FLV 14.061111026340061, 13.239999930063883 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 1653 916 170 E21K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 66.2 5.2 Yes 3.0 58.05 MOPS 50 mM DSC Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 4.0 1FTG, 1FLV 14.061111026340061, 13.239999930063883 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 1983 916 170 E21K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 18.1 5.0 Yes 48.25 Mops 50 mM NaCl 0.5 M Fluorescence, CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 4.0 1FTG, 1FLV 14.061111026340061, 13.239999930063883 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, EASE-MM_S1676.csv, PON-TStab_dataset.csv 7880 916 170 E21K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) -0.14 Yes 3.0 MOPS 50 mM 44.3 CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 4.0 1FTG, 1FLV 14.061111026340061, 13.239999930063883 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm khan_protherm_data_mapped.csv 7888 916 170 E21K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.2 Yes 3.0 MOPS 50 mM 44.3 CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 4.0 1FTG, 1FLV 14.061111026340061, 13.239999930063883 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 7896 916 170 E21K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.06 Yes 3.0 MOPS 50 mM 44.3 CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 4.0 1FTG, 1FLV 14.061111026340061, 13.239999930063883 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 7904 916 170 E21K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) -0.24 Yes 3.0 MOPS 50 mM 44.3 DSC Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 4.0 1FTG, 1FLV 14.061111026340061, 13.239999930063883 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 7910 916 170 E21K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.95 Yes 3.0 MOPS 50 mM 44.3 DSC Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 4.0 1FTG, 1FLV 14.061111026340061, 13.239999930063883 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 7916 916 170 E21K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.71 Yes 3.0 MOPS 50 mM 44.3 DSC Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 4.0 1FTG, 1FLV 14.061111026340061, 13.239999930063883 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 7994 916 170 E21K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.34 -0.27 Yes Mops 50 mM 43.4 NaCl 0.5 M Fluorescence, CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 4.0 1FTG, 1FLV 14.061111026340061, 13.239999930063883 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm 8479 916 170 E21K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.06 -0.28 Yes Mops 50 mM 25.2 NaCl 0.5 M Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 4.0 1FTG, 1FLV 14.061111026340061, 13.239999930063883 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm 9303 916 170 E21K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 2.56 -1.6 2.58 Yes MOPS 50 mM 25.0 Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 4.0 1FTG, 1FLV 14.061111026340061, 13.239999930063883 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 15934 7501 170 E21K, E73K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 18.9 9.5 Yes 52.75 Mops 50 mM NaCl 0.5 M Fluorescence, CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 4.0, 3.0 1FTG, 1FLV 14.061111026340061, 32.76999961005317, 13.239999930063883, 9.043333265516493 in pocket 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm 16797 7501 170 E21K, E73K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.34 -0.5 Yes Mops 50 mM 43.4 NaCl 0.5 M Fluorescence, CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 4.0, 3.0 1FTG, 1FLV 14.061111026340061, 32.76999961005317, 13.239999930063883, 9.043333265516493 in pocket 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm 16863 7501 170 E21K, E73K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.15 -0.35 Yes Mops 50 mM 25.2 NaCl 0.5 M Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 4.0, 3.0 1FTG, 1FLV 14.061111026340061, 32.76999961005317, 13.239999930063883, 9.043333265516493 in pocket 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm 1660 924 170 I23V Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 33.0 -6.3 yes 3.0 37.85 MOPS 50 mM NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0 1FTG, 1FLV 6.966249942779541, 7.932500004768372 in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 1678 924 170 I23V Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 37.3 -4.3 yes 3.0 51.55 MOPS 50 mM NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0 1FTG, 1FLV 6.966249942779541, 7.932500004768372 in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 9319 924 170 I23V Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.46 1.94 2.13 yes MOPS 50 mM 25.0 NaCl 15 mM CD Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0 1FTG, 1FLV 6.966249942779541, 7.932500004768372 in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 1984 1106 170 I23A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 13.1 -0.5 Yes 42.75 Mops 50 mM NaCl 0.5 M Fluorescence, CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0 1FTG, 1FLV 6.966249942779541, 7.932500004768372 in pocket 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, HotMuSiC_S1626.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 7923 1106 170 I23A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.67 yes 3.0 MOPS 50 mM 44.3 NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0 1FTG, 1FLV 6.966249942779541, 7.932500004768372 in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm khan_protherm_data_mapped.csv 7941 1106 170 I23A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.03 yes 3.0 MOPS 50 mM 44.3 NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0 1FTG, 1FLV 6.966249942779541, 7.932500004768372 in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 7995 1106 170 I23A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.34 0.02 Yes Mops 50 mM 43.4 NaCl 0.5 M Fluorescence, CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0 1FTG, 1FLV 6.966249942779541, 7.932500004768372 in pocket 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm 8480 1106 170 I23A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.62 0.02 Yes Mops 50 mM 25.2 NaCl 0.5 M Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0 1FTG, 1FLV 6.966249942779541, 7.932500004768372 in pocket 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm 1985 1107 170 I23G Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 14.6 3.8 Yes 47.05 Mops 50 mM NaCl 0.5 M Fluorescence, CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0 1FTG, 1FLV 6.966249942779541, 7.932500004768372 in pocket 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, HotMuSiC_S1626.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 7996 1107 170 I23G Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.34 -0.17 Yes Mops 50 mM 43.4 NaCl 0.5 M Fluorescence, CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0 1FTG, 1FLV 6.966249942779541, 7.932500004768372 in pocket 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm 8481 1107 170 I23G Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.66 -0.01 Yes Mops 50 mM 25.2 NaCl 0.5 M Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0 1FTG, 1FLV 6.966249942779541, 7.932500004768372 in pocket 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm 1661 925 170 V32A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 30.9 -4.7 yes 3.0 39.45 MOPS 50 mM NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 6.0 1FTG, 1FLV 11.185714381081718, 20.198571341378347 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 1679 925 170 V32A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 41.5 -4.8 yes 3.0 51.05 MOPS 50 mM NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 6.0 1FTG, 1FLV 11.185714381081718, 20.198571341378347 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 7924 925 170 V32A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.46 yes 3.0 MOPS 50 mM 44.3 NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 6.0 1FTG, 1FLV 11.185714381081718, 20.198571341378347 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm khan_protherm_data_mapped.csv 7942 925 170 V32A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.99 yes 3.0 MOPS 50 mM 44.3 NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 6.0 1FTG, 1FLV 11.185714381081718, 20.198571341378347 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 9320 925 170 V32A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.31 2.39 2.02 yes MOPS 50 mM 25.0 NaCl 15 mM CD Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 6.0 1FTG, 1FLV 11.185714381081718, 20.198571341378347 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 10979 4674 170 H35A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.99 0.83 Unknown MES 375 mM 25.0 Fluorescence Urea 6.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 9.37999997138977, 9.950000047683716 10388575 10.1006/jmbi.1999.2863 1999 ProTherm 10982 4674 170 H35A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.1 1.77 Unknown Tris 583 mM 25.0 Fluorescence Urea 8.5 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 9.37999997138977, 9.950000047683716 10388575 10.1006/jmbi.1999.2863 1999 ProTherm 15382 7142 170 H35A, Y48F Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 2.09 0.63 Unknown MES 375 mM 25.0 Fluorescence Urea 6.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0, 5.0 1FTG, 1FLV 9.37999997138977, 8.957500020662943, 9.950000047683716, 9.68583337465922 10388575 10.1006/jmbi.1999.2863 1999 ProTherm 15384 7142 170 H35A, Y48F Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.19 1.54 Unknown Tris 583 mM 25.0 Fluorescence Urea 8.5 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0, 5.0 1FTG, 1FLV 9.37999997138977, 8.957500020662943, 9.950000047683716, 9.68583337465922 10388575 10.1006/jmbi.1999.2863 1999 ProTherm 1633 917 170 E41K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 33.5 0.6 Yes 3.0 44.75 MOPS 50 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 26.051111221313477, 20.384444342719185 in pocket 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 1641 917 170 E41K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 62.5 4.5 Yes 3.0 60.35 MOPS 50 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 26.051111221313477, 20.384444342719185 in pocket 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 1649 917 170 E41K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 32.7 4.5 Yes 3.0 43.35 MOPS 50 mM DSC Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 26.051111221313477, 20.384444342719185 in pocket 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 1654 917 170 E41K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 59.6 6.6 Yes 3.0 59.35 MOPS 50 mM DSC Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 26.051111221313477, 20.384444342719185 in pocket 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 1986 917 170 E41K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 10.8 5.4 Yes 48.65 Mops 50 mM NaCl 0.5 M Fluorescence, CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 26.051111221313477, 20.384444342719185 in pocket 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, M47andM8_S1810.csv, PON-TStab_dataset.csv 7881 917 170 E41K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.06 Yes 3.0 MOPS 50 mM 44.3 CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 26.051111221313477, 20.384444342719185 in pocket 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm khan_protherm_data_mapped.csv 7889 917 170 E41K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.16 Yes 3.0 MOPS 50 mM 44.3 CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 26.051111221313477, 20.384444342719185 in pocket 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 7897 917 170 E41K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.22 Yes 3.0 MOPS 50 mM 44.3 CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 26.051111221313477, 20.384444342719185 in pocket 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 7905 917 170 E41K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.4 Yes 3.0 MOPS 50 mM 44.3 DSC Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 26.051111221313477, 20.384444342719185 in pocket 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 7911 917 170 E41K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.12 Yes 3.0 MOPS 50 mM 44.3 DSC Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 26.051111221313477, 20.384444342719185 in pocket 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 7917 917 170 E41K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.52 Yes 3.0 MOPS 50 mM 44.3 DSC Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 26.051111221313477, 20.384444342719185 in pocket 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 7997 917 170 E41K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.34 -0.17 Yes Mops 50 mM 43.4 NaCl 0.5 M Fluorescence, CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 26.051111221313477, 20.384444342719185 in pocket 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm 8482 917 170 E41K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.2 -0.38 Yes Mops 50 mM 25.2 NaCl 0.5 M Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 26.051111221313477, 20.384444342719185 in pocket 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm 9304 917 170 E41K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 2.66 -2.21 2.73 Yes MOPS 50 mM 25.0 Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 26.051111221313477, 20.384444342719185 in pocket 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 1662 926 170 D44A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 34.1 0.4 yes 3.0 44.55 MOPS 50 mM NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 2.0 1FTG, 1FLV 10.97000002861023, 13.861250042915344 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 1680 926 170 D44A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 49.5 0.6 yes 3.0 56.45 MOPS 50 mM NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 2.0 1FTG, 1FLV 10.97000002861023, 13.861250042915344 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 7925 926 170 D44A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) -0.04 yes 3.0 MOPS 50 mM 44.3 NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 2.0 1FTG, 1FLV 10.97000002861023, 13.861250042915344 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm potapov_with_uniprot_mapping.csv 7943 926 170 D44A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.03 yes 3.0 MOPS 50 mM 44.3 NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 2.0 1FTG, 1FLV 10.97000002861023, 13.861250042915344 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 9321 926 170 D44A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 2.11 -0.09 2.43 yes MOPS 50 mM 25.0 NaCl 15 mM CD Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 2.0 1FTG, 1FLV 10.97000002861023, 13.861250042915344 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm potapov_with_uniprot_mapping.csv 10978 4673 170 Y48F Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 2.11 0.59 Unknown MES 375 mM 25.0 Fluorescence Urea 6.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 5.0 1FTG, 1FLV 8.957500020662943, 9.68583337465922 10388575 10.1006/jmbi.1999.2863 1999 ProTherm 10981 4673 170 Y48F Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.37 1.07 Unknown Tris 583 mM 25.0 Fluorescence Urea 8.5 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 5.0 1FTG, 1FLV 8.957500020662943, 9.68583337465922 10388575 10.1006/jmbi.1999.2863 1999 ProTherm 1987 1108 170 L51A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 12.6 0.6 Yes 43.85 Mops 50 mM NaCl 0.5 M Fluorescence, CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 6.0 1FTG, 1FLV 7.991249859333038, 4.805000007152557 in pocket 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 7998 1108 170 L51A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.34 -0.02 Yes Mops 50 mM 43.4 NaCl 0.5 M Fluorescence, CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 6.0 1FTG, 1FLV 7.991249859333038, 4.805000007152557 in pocket 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8483 1108 170 L51A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.72 -0.05 Yes Mops 50 mM 25.2 NaCl 0.5 M Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 6.0 1FTG, 1FLV 7.991249859333038, 4.805000007152557 in pocket 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm 1663 927 170 I52V Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 31.2 -4.1 yes 3.0 40.05 MOPS 50 mM NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0 1FTG, 1FLV 6.026249945163727, 3.39124995470047 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 1681 927 170 I52V Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 38.8 -4.7 yes 3.0 51.15 MOPS 50 mM NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0 1FTG, 1FLV 6.026249945163727, 3.39124995470047 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 7926 927 170 I52V Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.41 yes 3.0 MOPS 50 mM 44.3 NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0 1FTG, 1FLV 6.026249945163727, 3.39124995470047 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm khan_protherm_data_mapped.csv 7944 927 170 I52V Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.04 yes 3.0 MOPS 50 mM 44.3 NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0 1FTG, 1FLV 6.026249945163727, 3.39124995470047 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 9322 927 170 I52V Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.27 1.98 2.42 yes MOPS 50 mM 25.0 NaCl 15 mM CD Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0 1FTG, 1FLV 6.026249945163727, 3.39124995470047 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 1664 928 170 I53V Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 39.8 -1.4 yes 3.0 42.75 MOPS 50 mM NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 6.0 1FTG, 1FLV 6.522499978542328, 2.1637499928474426 in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 1682 928 170 I53V Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 54.5 -4.1 yes 3.0 51.75 MOPS 50 mM NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 6.0 1FTG, 1FLV 6.522499978542328, 2.1637499928474426 in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 7927 928 170 I53V Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.18 yes 3.0 MOPS 50 mM 44.3 NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 6.0 1FTG, 1FLV 6.522499978542328, 2.1637499928474426 in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm khan_protherm_data_mapped.csv 7945 928 170 I53V Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.6 yes 3.0 MOPS 50 mM 44.3 NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 6.0 1FTG, 1FLV 6.522499978542328, 2.1637499928474426 in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 9323 928 170 I53V Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.45 1.38 2.52 yes MOPS 50 mM 25.0 NaCl 15 mM CD Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 6.0 1FTG, 1FLV 6.522499978542328, 2.1637499928474426 in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 1634 918 170 E62K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 41.0 3.6 Yes 3.0 47.75 MOPS 50 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 49.326666514078774, 6.85444450378418 in tunnel in pocket 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 1642 918 170 E62K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 38.0 2.7 Yes 3.0 58.55 MOPS 50 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 49.326666514078774, 6.85444450378418 in tunnel in pocket 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 7882 918 170 E62K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.46 Yes 3.0 MOPS 50 mM 44.3 CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 49.326666514078774, 6.85444450378418 in tunnel in pocket 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 7890 918 170 E62K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) -0.22 Yes 3.0 MOPS 50 mM 44.3 CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 49.326666514078774, 6.85444450378418 in tunnel in pocket 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm khan_protherm_data_mapped.csv 7898 918 170 E62K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.24 Yes 3.0 MOPS 50 mM 44.3 CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 49.326666514078774, 6.85444450378418 in tunnel in pocket 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm potapov_with_uniprot_mapping.csv 9305 918 170 E62K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 2.24 -0.88 2.66 Yes MOPS 50 mM 25.0 Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 49.326666514078774, 6.85444450378418 in tunnel in pocket 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 1635 919 170 D66K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 30.4 -2.1 Yes 3.0 42.05 MOPS 50 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0 1FTG, 1FLV 18.413749933242798, 8.927500009536743 in pocket 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 1643 919 170 D66K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 54.9 0.2 Yes 3.0 56.05 MOPS 50 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0 1FTG, 1FLV 18.413749933242798, 8.927500009536743 in pocket 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 7883 919 170 D66K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) -0.2 Yes 3.0 MOPS 50 mM 44.3 CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0 1FTG, 1FLV 18.413749933242798, 8.927500009536743 in pocket 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 7891 919 170 D66K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.11 Yes 3.0 MOPS 50 mM 44.3 CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0 1FTG, 1FLV 18.413749933242798, 8.927500009536743 in pocket 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 7899 919 170 D66K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) -0.09 Yes 3.0 MOPS 50 mM 44.3 CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0 1FTG, 1FLV 18.413749933242798, 8.927500009536743 in pocket 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 9306 919 170 D66K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 2.09 0.26 2.29 Yes MOPS 50 mM 25.0 Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0 1FTG, 1FLV 18.413749933242798, 8.927500009536743 in pocket 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 1988 1109 170 G69A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 19.5 6.7 Yes 49.95 Mops 50 mM NaCl 0.5 M Fluorescence, CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 5.0 1FTG, 1FLV 31.977499961853027, 8.819999933242798 in pocket 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 7999 1109 170 G69A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.34 -0.38 Yes Mops 50 mM 43.4 NaCl 0.5 M Fluorescence, CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 5.0 1FTG, 1FLV 31.977499961853027, 8.819999933242798 in pocket 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8484 1109 170 G69A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.3 -0.45 Yes Mops 50 mM 25.2 NaCl 0.5 M Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 5.0 1FTG, 1FLV 31.977499961853027, 8.819999933242798 in pocket 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm 1665 929 170 S72A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 34.5 -1.0 yes 3.0 43.15 MOPS 50 mM NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 32.76499970753988, 7.681666612625122 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 1683 929 170 S72A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 55.0 0.3 yes 3.0 56.15 MOPS 50 mM NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 32.76499970753988, 7.681666612625122 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 7928 929 170 S72A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.11 yes 3.0 MOPS 50 mM 44.3 NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 32.76499970753988, 7.681666612625122 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 7946 929 170 S72A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) -0.13 yes 3.0 MOPS 50 mM 44.3 NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 32.76499970753988, 7.681666612625122 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 9324 929 170 S72A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.77 0.65 2.49 yes MOPS 50 mM 25.0 NaCl 15 mM CD Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 32.76499970753988, 7.681666612625122 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 1636 920 170 E73K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 33.2 1.2 Yes 3.0 45.35 MOPS 50 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 32.76999961005317, 9.043333265516493 in pocket 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 1644 920 170 E73K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 57.8 7.2 Yes 3.0 63.05 MOPS 50 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 32.76999961005317, 9.043333265516493 in pocket 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 1650 920 170 E73K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 27.2 0.8 Yes 3.0 39.65 MOPS 50 mM DSC Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 32.76999961005317, 9.043333265516493 in pocket 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 1655 920 170 E73K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 68.4 7.6 Yes 3.0 60.45 MOPS 50 mM DSC Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 32.76999961005317, 9.043333265516493 in pocket 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 1989 920 170 E73K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 18.4 6.2 Yes 49.45 Mops 50 mM NaCl 0.5 M Fluorescence, CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 32.76999961005317, 9.043333265516493 in pocket 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, M47andM8_S1810.csv 7884 920 170 E73K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.13 Yes 3.0 MOPS 50 mM 44.3 CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 32.76999961005317, 9.043333265516493 in pocket 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 7892 920 170 E73K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.38 Yes 3.0 MOPS 50 mM 44.3 CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 32.76999961005317, 9.043333265516493 in pocket 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 7900 920 170 E73K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.5 Yes 3.0 MOPS 50 mM 44.3 CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 32.76999961005317, 9.043333265516493 in pocket 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 7906 920 170 E73K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.07 Yes 3.0 MOPS 50 mM 44.3 DSC Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 32.76999961005317, 9.043333265516493 in pocket 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm khan_protherm_data_mapped.csv 7912 920 170 E73K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.4 Yes 3.0 MOPS 50 mM 44.3 DSC Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 32.76999961005317, 9.043333265516493 in pocket 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 7918 920 170 E73K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.47 Yes 3.0 MOPS 50 mM 44.3 DSC Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 32.76999961005317, 9.043333265516493 in pocket 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 8000 920 170 E73K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.34 -0.33 Yes Mops 50 mM 43.4 NaCl 0.5 M Fluorescence, CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 32.76999961005317, 9.043333265516493 in pocket 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm 8485 920 170 E73K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.07 -0.29 Yes Mops 50 mM 25.2 NaCl 0.5 M Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 32.76999961005317, 9.043333265516493 in pocket 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm 9307 920 170 E73K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 2.64 -1.28 2.4 Yes MOPS 50 mM 25.0 Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 32.76999961005317, 9.043333265516493 in pocket 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 1637 921 170 D76K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 34.2 0.1 Yes 3.0 44.25 MOPS 50 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 2.0 1FTG, 1FLV 32.81375002861023, 18.731249809265137 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 1645 921 170 D76K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 59.6 5.2 Yes 3.0 61.05 MOPS 50 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 2.0 1FTG, 1FLV 32.81375002861023, 18.731249809265137 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 1651 921 170 D76K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 28.3 2.8 Yes 3.0 41.65 MOPS 50 mM DSC Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 2.0 1FTG, 1FLV 32.81375002861023, 18.731249809265137 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 1656 921 170 D76K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 54.3 4.0 Yes 3.0 56.85 MOPS 50 mM DSC Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 2.0 1FTG, 1FLV 32.81375002861023, 18.731249809265137 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 1990 921 170 D76K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 17.7 7.8 Yes 51.05 Mops 50 mM NaCl 0.5 M Fluorescence, CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 2.0 1FTG, 1FLV 32.81375002861023, 18.731249809265137 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 7885 921 170 D76K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.01 Yes 3.0 MOPS 50 mM 44.3 CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 2.0 1FTG, 1FLV 32.81375002861023, 18.731249809265137 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm khan_protherm_data_mapped.csv 7893 921 170 D76K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.14 Yes 3.0 MOPS 50 mM 44.3 CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 2.0 1FTG, 1FLV 32.81375002861023, 18.731249809265137 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 7901 921 170 D76K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.15 Yes 3.0 MOPS 50 mM 44.3 CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 2.0 1FTG, 1FLV 32.81375002861023, 18.731249809265137 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 7907 921 170 D76K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.25 Yes 3.0 MOPS 50 mM 44.3 DSC Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 2.0 1FTG, 1FLV 32.81375002861023, 18.731249809265137 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 7913 921 170 D76K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.73 Yes 3.0 MOPS 50 mM 44.3 DSC Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 2.0 1FTG, 1FLV 32.81375002861023, 18.731249809265137 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 7919 921 170 D76K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.98 Yes 3.0 MOPS 50 mM 44.3 DSC Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 2.0 1FTG, 1FLV 32.81375002861023, 18.731249809265137 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 8001 921 170 D76K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.34 -0.4 Yes Mops 50 mM 43.4 NaCl 0.5 M Fluorescence, CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 2.0 1FTG, 1FLV 32.81375002861023, 18.731249809265137 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm 8486 921 170 D76K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.1 -0.31 Yes Mops 50 mM 25.2 NaCl 0.5 M Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 2.0 1FTG, 1FLV 32.81375002861023, 18.731249809265137 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm 9308 921 170 D76K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 2.47 -1.0 2.45 Yes MOPS 50 mM 25.0 Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 2.0 1FTG, 1FLV 32.81375002861023, 18.731249809265137 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 1991 1110 170 V84I Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 14.8 1.0 Yes 44.25 Mops 50 mM NaCl 0.5 M Fluorescence, CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 5.25, 4.010000058582851 in pocket 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 2359 1110 170 V84I Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 33.3 0.3 Yes 3.0 44.45 Mops 5-50 mM NaCl 15 mM Abs, CD, Fluorescence Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 5.25, 4.010000058582851 in pocket 16563433 10.1016/j.jmb.2006.02.060 2006 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, HotMuSiC_S1626.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, STRUM_Q306.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv 2362 1110 170 V84I Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 53.1 -0.1 Yes 3.0 55.75 Mops 5-50 mM NaCl 15 mM Abs, CD, Fluorescence Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 5.25, 4.010000058582851 in pocket 16563433 10.1016/j.jmb.2006.02.060 2006 ProTherm Broom_S605.csv, STRUM_Q3421.csv, EASE-MM_S238.csv, PON-TStab_dataset.csv 7960 1110 170 V84I Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) -0.03 Yes 3.0 Mops 5-50 mM 44.3 NaCl 15 mM Abs, CD, Fluorescence Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 5.25, 4.010000058582851 in pocket 16563433 10.1016/j.jmb.2006.02.060 2006 ProTherm potapov_with_uniprot_mapping.csv 7962 1110 170 V84I Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.01 Yes 3.0 Mops 5-50 mM 44.3 NaCl 15 mM Abs, CD, Fluorescence Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 5.25, 4.010000058582851 in pocket 16563433 10.1016/j.jmb.2006.02.060 2006 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 7965 1110 170 V84I Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.03 Yes Mops 5-50 mM 44.3 NaCl 15 mM Abs, CD, Fluorescence Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 5.25, 4.010000058582851 in pocket 16563433 10.1016/j.jmb.2006.02.060 2006 ProTherm potapov_with_uniprot_mapping.csv 8002 1110 170 V84I Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.34 -0.05 Yes Mops 50 mM 43.4 NaCl 0.5 M Fluorescence, CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 5.25, 4.010000058582851 in pocket 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm khan_protherm_data_mapped.csv 8487 1110 170 V84I Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.74 -0.06 Yes Mops 50 mM 25.2 NaCl 0.5 M Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 5.25, 4.010000058582851 in pocket 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm 9928 1110 170 V84I Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 2.08 -0.13 2.49 Yes Mops 50 mM 25.0 Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 5.25, 4.010000058582851 in pocket 16563433 10.1016/j.jmb.2006.02.060 2006 ProTherm SAAFEC_S1262.csv 1666 930 170 A85G Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 34.4 -4.3 yes 3.0 39.85 MOPS 50 mM NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 9.0 1FTG, 1FLV 6.507999992370605, 3.1459999561309813 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 1684 930 170 A85G Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 31.9 -5.4 yes 3.0 50.45 MOPS 50 mM NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 9.0 1FTG, 1FLV 6.507999992370605, 3.1459999561309813 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 7929 930 170 A85G Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.47 yes 3.0 MOPS 50 mM 44.3 NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 9.0 1FTG, 1FLV 6.507999992370605, 3.1459999561309813 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm khan_protherm_data_mapped.csv 7947 930 170 A85G Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.25 yes 3.0 MOPS 50 mM 44.3 NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 9.0 1FTG, 1FLV 6.507999992370605, 3.1459999561309813 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 9325 930 170 A85G Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.28 2.17 2.25 yes MOPS 50 mM 25.0 NaCl 15 mM CD Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 9.0 1FTG, 1FLV 6.507999992370605, 3.1459999561309813 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 2363 1201 170 G88A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 49.1 Yes 2.0 56.15 Mops 5-50 mM NaCl 15 mM Abs, CD, Fluorescence Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 9.0 1FTG, 1FLV 5.557500064373016, 2.5800000429153442 in pocket 16563433 10.1016/j.jmb.2006.02.060 2006 ProTherm AUTOMUTE_S1925.csv, AUTOMUTE_S1962.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, EASE-MM_S238.csv 7966 1201 170 G88A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.09 Yes 2.0 Mops 5-50 mM 44.3 NaCl 15 mM Abs, CD, Fluorescence Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 9.0 1FTG, 1FLV 5.557500064373016, 2.5800000429153442 in pocket 16563433 10.1016/j.jmb.2006.02.060 2006 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 9929 1201 170 G88A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 2.09 0.13 2.36 Yes Mops 50 mM 25.0 Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 9.0 1FTG, 1FLV 5.557500064373016, 2.5800000429153442 in pocket 16563433 10.1016/j.jmb.2006.02.060 2006 ProTherm SAAFEC_S1262.csv 2364 1202 170 G88V Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 45.3 Yes 2.0 58.85 Mops 5-50 mM NaCl 15 mM Abs, CD, Fluorescence Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 9.0 1FTG, 1FLV 5.557500064373016, 2.5800000429153442 in pocket 16563433 10.1016/j.jmb.2006.02.060 2006 ProTherm AUTOMUTE_S1925.csv, AUTOMUTE_S1962.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S2204.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 7967 1202 170 G88V Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) -0.12 Yes 2.0 Mops 5-50 mM 44.3 NaCl 15 mM Abs, CD, Fluorescence Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 9.0 1FTG, 1FLV 5.557500064373016, 2.5800000429153442 in pocket 16563433 10.1016/j.jmb.2006.02.060 2006 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 9930 1202 170 G88V Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 2.27 0.13 2.17 Yes Mops 50 mM 25.0 Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 9.0 1FTG, 1FLV 5.557500064373016, 2.5800000429153442 in pocket 16563433 10.1016/j.jmb.2006.02.060 2006 ProTherm SAAFEC_S1262.csv 2365 1203 170 G88L Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 41.3 Yes 2.0 57.55 Mops 5-50 mM NaCl 15 mM Abs, CD, Fluorescence Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 9.0 1FTG, 1FLV 5.557500064373016, 2.5800000429153442 in pocket 16563433 10.1016/j.jmb.2006.02.060 2006 ProTherm AUTOMUTE_S1925.csv, AUTOMUTE_S1962.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 7968 1203 170 G88L Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.21 Yes 2.0 Mops 5-50 mM 44.3 NaCl 15 mM Abs, CD, Fluorescence Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 9.0 1FTG, 1FLV 5.557500064373016, 2.5800000429153442 in pocket 16563433 10.1016/j.jmb.2006.02.060 2006 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 9931 1203 170 G88L Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 2.2 0.64 2.01 Yes Mops 50 mM 25.0 Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 9.0 1FTG, 1FLV 5.557500064373016, 2.5800000429153442 in pocket 16563433 10.1016/j.jmb.2006.02.060 2006 ProTherm SAAFEC_S1262.csv 1667 931 170 N98A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 28.6 -2.4 yes 3.0 41.75 MOPS 50 mM NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 10.561250030994415, 2.527499943971634 in tunnel in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 1685 931 170 N98A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 48.7 -0.7 yes 3.0 55.15 MOPS 50 mM NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 10.561250030994415, 2.527499943971634 in tunnel in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 7930 931 170 N98A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.22 yes 3.0 MOPS 50 mM 44.3 NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 10.561250030994415, 2.527499943971634 in tunnel in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 7948 931 170 N98A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.24 yes 3.0 MOPS 50 mM 44.3 NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 10.561250030994415, 2.527499943971634 in tunnel in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm potapov_with_uniprot_mapping.csv 9326 931 170 N98A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.86 0.83 2.27 yes MOPS 50 mM 25.0 NaCl 15 mM CD Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 10.561250030994415, 2.527499943971634 in tunnel in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 1668 932 170 Q100A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 52.7 5.2 yes 3.0 49.35 MOPS 50 mM NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 7.4799999660915795, 3.3122222158643932 in tunnel in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 1686 932 170 Q100A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 56.2 2.3 yes 3.0 58.15 MOPS 50 mM NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 7.4799999660915795, 3.3122222158643932 in tunnel in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 1992 932 170 Q100A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 17.8 8.5 Yes 51.75 Mops 50 mM NaCl 0.5 M Fluorescence, CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 7.4799999660915795, 3.3122222158643932 in tunnel in pocket 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, PoPMuSiC-2.0_S2648.csv, PON-TStab_dataset.csv, SVM-WIN31_SVM-3D12_S499.csv 7931 932 170 Q100A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) -0.85 yes 3.0 MOPS 50 mM 44.3 NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 7.4799999660915795, 3.3122222158643932 in tunnel in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 7949 932 170 Q100A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) -0.49 yes 3.0 MOPS 50 mM 44.3 NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 7.4799999660915795, 3.3122222158643932 in tunnel in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm potapov_with_uniprot_mapping.csv 8003 932 170 Q100A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.34 -0.43 Yes Mops 50 mM 43.4 NaCl 0.5 M Fluorescence, CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 7.4799999660915795, 3.3122222158643932 in tunnel in pocket 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm khan_protherm_data_mapped.csv 8488 932 170 Q100A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.0 -0.24 Yes Mops 50 mM 25.2 NaCl 0.5 M Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 7.4799999660915795, 3.3122222158643932 in tunnel in pocket 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm 9327 932 170 Q100A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 2.33 -1.72 2.9 yes MOPS 50 mM 25.0 NaCl 15 mM CD Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 7.4799999660915795, 3.3122222158643932 in tunnel in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 1993 1111 170 A102V Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 10.5 5.4 Yes 48.65 Mops 50 mM NaCl 0.5 M Fluorescence, CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0 1FTG, 1FLV 4.675999975204467, 3.650000047683716 in tunnel in pocket 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm AUTOMUTE_S1925.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, Saraboji_S1396.csv, EASE-MM_S1676.csv, PON-TStab_dataset.csv, STRUM_Q3421.csv 2366 1111 170 A102V Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 43.6 Yes 2.0 53.05 Mops 5-50 mM NaCl 15 mM Abs, CD, Fluorescence Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0 1FTG, 1FLV 4.675999975204467, 3.650000047683716 in tunnel in pocket 16563433 10.1016/j.jmb.2006.02.060 2006 ProTherm AUTOMUTE_S1925.csv, AUTOMUTE_S1962.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 7969 1111 170 A102V Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.69 Yes 2.0 Mops 5-50 mM 44.3 NaCl 15 mM Abs, CD, Fluorescence Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0 1FTG, 1FLV 4.675999975204467, 3.650000047683716 in tunnel in pocket 16563433 10.1016/j.jmb.2006.02.060 2006 ProTherm khan_protherm_data_mapped.csv 8004 1111 170 A102V Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.34 -0.16 Yes Mops 50 mM 43.4 NaCl 0.5 M Fluorescence, CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0 1FTG, 1FLV 4.675999975204467, 3.650000047683716 in tunnel in pocket 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8489 1111 170 A102V Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.97 -0.22 Yes Mops 50 mM 25.2 NaCl 0.5 M Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0 1FTG, 1FLV 4.675999975204467, 3.650000047683716 in tunnel in pocket 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm potapov_with_uniprot_mapping.csv 9932 1111 170 A102V Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.95 0.32 2.43 Yes Mops 50 mM 25.0 Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0 1FTG, 1FLV 4.675999975204467, 3.650000047683716 in tunnel in pocket 16563433 10.1016/j.jmb.2006.02.060 2006 ProTherm SAAFEC_S1262.csv 2367 1204 170 A102L Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 36.4 Yes 2.0 56.35 Mops 5-50 mM NaCl 15 mM Abs, CD, Fluorescence Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0 1FTG, 1FLV 4.675999975204467, 3.650000047683716 in tunnel in pocket 16563433 10.1016/j.jmb.2006.02.060 2006 ProTherm AUTOMUTE_S1925.csv, AUTOMUTE_S1962.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, PoPMuSiC-2.0_S2648.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 7970 1204 170 A102L Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.53 Yes 2.0 Mops 5-50 mM 44.3 NaCl 15 mM Abs, CD, Fluorescence Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0 1FTG, 1FLV 4.675999975204467, 3.650000047683716 in tunnel in pocket 16563433 10.1016/j.jmb.2006.02.060 2006 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 9933 1204 170 A102L Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 2.12 -0.08 2.42 Yes Mops 50 mM 25.0 Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 8.0 1FTG, 1FLV 4.675999975204467, 3.650000047683716 in tunnel in pocket 16563433 10.1016/j.jmb.2006.02.060 2006 ProTherm SAAFEC_S1262.csv 1669 933 170 I105V Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 29.5 -4.0 yes 3.0 40.15 MOPS 50 mM NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 4.0 1FTG, 1FLV 9.858749866485596, 2.4974999725818634 in tunnel in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 1687 933 170 I105V Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 54.5 -1.1 yes 3.0 54.75 MOPS 50 mM NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 4.0 1FTG, 1FLV 9.858749866485596, 2.4974999725818634 in tunnel in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 7932 933 170 I105V Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.38 yes 3.0 MOPS 50 mM 44.3 NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 4.0 1FTG, 1FLV 9.858749866485596, 2.4974999725818634 in tunnel in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 7950 933 170 I105V Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.11 yes 3.0 MOPS 50 mM 44.3 NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 4.0 1FTG, 1FLV 9.858749866485596, 2.4974999725818634 in tunnel in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm khan_protherm_data_mapped.csv 9328 933 170 I105V Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.82 0.67 2.41 yes MOPS 50 mM 25.0 NaCl 15 mM CD Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 4.0 1FTG, 1FLV 9.858749866485596, 2.4974999725818634 in tunnel in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 1994 1112 170 E108A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 17.5 2.7 Yes 45.95 Mops 50 mM NaCl 0.5 M Fluorescence, CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 4.0 1FTG, 1FLV 21.31999969482422, 11.997777620951334 in pocket 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, HotMuSiC_S1626.csv, M47andM8_S1810.csv 8005 1112 170 E108A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.34 -0.15 Yes Mops 50 mM 43.4 NaCl 0.5 M Fluorescence, CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 4.0 1FTG, 1FLV 21.31999969482422, 11.997777620951334 in pocket 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8490 1112 170 E108A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.98 -0.23 Yes Mops 50 mM 25.2 NaCl 0.5 M Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 4.0 1FTG, 1FLV 21.31999969482422, 11.997777620951334 in pocket 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm 1670 934 170 S111A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 32.5 -1.7 yes 3.0 42.45 MOPS 50 mM NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 1.0 1FTG, 1FLV 18.448333581288654, 8.175000111262003 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 1688 934 170 S111A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 44.3 -0.3 yes 3.0 55.55 MOPS 50 mM NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 1.0 1FTG, 1FLV 18.448333581288654, 8.175000111262003 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 7933 934 170 S111A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.18 yes 3.0 MOPS 50 mM 44.3 NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 1.0 1FTG, 1FLV 18.448333581288654, 8.175000111262003 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 7951 934 170 S111A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.34 yes 3.0 MOPS 50 mM 44.3 NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 1.0 1FTG, 1FLV 18.448333581288654, 8.175000111262003 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm potapov_with_uniprot_mapping.csv 9329 934 170 S111A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.79 1.03 2.25 yes MOPS 50 mM 25.0 NaCl 15 mM CD Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 1.0 1FTG, 1FLV 18.448333581288654, 8.175000111262003 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 1995 1113 170 Q112G Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 19.8 3.7 Yes 46.95 Mops 50 mM NaCl 0.5 M Fluorescence, CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 1.0 1FTG, 1FLV 29.13111135694716, 12.626666598849827 in pocket 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, HotMuSiC_S1626.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv, M47andM8_S1810.csv 8006 1113 170 Q112G Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.34 -0.22 Yes Mops 50 mM 43.4 NaCl 0.5 M Fluorescence, CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 1.0 1FTG, 1FLV 29.13111135694716, 12.626666598849827 in pocket 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 8491 1113 170 Q112G Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.79 -0.1 Yes Mops 50 mM 25.2 NaCl 0.5 M Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 1.0 1FTG, 1FLV 29.13111135694716, 12.626666598849827 in pocket 16364364 10.1016/j.jmb.2005.10.086 2006 ProTherm 1671 935 170 V118A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 36.9 -8.0 yes 3.0 36.15 MOPS 50 mM NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 11.845714160374232, 6.277142797197614 in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 1689 935 170 V118A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 33.7 -6.4 yes 3.0 49.45 MOPS 50 mM NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 11.845714160374232, 6.277142797197614 in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 7934 935 170 V118A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.95 yes 3.0 MOPS 50 mM 44.3 NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 11.845714160374232, 6.277142797197614 in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm khan_protherm_data_mapped.csv 7952 935 170 V118A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.32 yes 3.0 MOPS 50 mM 44.3 NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 11.845714160374232, 6.277142797197614 in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 9330 935 170 V118A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.3 2.05 2.3 yes MOPS 50 mM 25.0 NaCl 15 mM CD Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 11.845714160374232, 6.277142797197614 in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 1672 936 170 T123S Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 35.5 5.9 yes 3.0 50.05 MOPS 50 mM NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 6.0 1FTG, 1FLV 6.114285741533552, 6.640000002724784 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 1690 936 170 T123S Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 50.7 1.3 yes 3.0 57.15 MOPS 50 mM NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 6.0 1FTG, 1FLV 6.114285741533552, 6.640000002724784 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 7935 936 170 T123S Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) -0.65 yes 3.0 MOPS 50 mM 44.3 NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 6.0 1FTG, 1FLV 6.114285741533552, 6.640000002724784 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 7953 936 170 T123S Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) -0.11 yes 3.0 MOPS 50 mM 44.3 NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 6.0 1FTG, 1FLV 6.114285741533552, 6.640000002724784 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm khan_protherm_data_mapped.csv 9331 936 170 T123S Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.93 0.37 2.42 yes MOPS 50 mM 25.0 NaCl 15 mM CD Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 6.0 1FTG, 1FLV 6.114285741533552, 6.640000002724784 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm potapov_with_uniprot_mapping.csv 263 139 170 D127K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 21.8 8.0 Yes 3.0 46.85 MOPS 50 mM DSC Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 19.449999928474426, 12.183750033378601 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 1638 139 170 D127K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 40.6 4.6 Yes 3.0 48.75 MOPS 50 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 19.449999928474426, 12.183750033378601 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 1646 139 170 D127K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 45.1 1.8 Yes 3.0 57.65 MOPS 50 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 19.449999928474426, 12.183750033378601 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 1657 139 170 D127K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 39.7 1.5 Yes 3.0 54.35 MOPS 50 mM DSC Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 19.449999928474426, 12.183750033378601 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 7886 139 170 D127K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.58 Yes 3.0 MOPS 50 mM 44.3 CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 19.449999928474426, 12.183750033378601 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm potapov_with_uniprot_mapping.csv 7894 139 170 D127K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) -0.03 Yes 3.0 MOPS 50 mM 44.3 CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 19.449999928474426, 12.183750033378601 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm khan_protherm_data_mapped.csv 7902 139 170 D127K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.55 Yes 3.0 MOPS 50 mM 44.3 CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 19.449999928474426, 12.183750033378601 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm potapov_with_uniprot_mapping.csv 7908 139 170 D127K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.71 Yes 3.0 MOPS 50 mM 44.3 DSC Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 19.449999928474426, 12.183750033378601 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 7914 139 170 D127K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.28 Yes 3.0 MOPS 50 mM 44.3 DSC Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 19.449999928474426, 12.183750033378601 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 7920 139 170 D127K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.99 Yes 3.0 MOPS 50 mM 44.3 DSC Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 19.449999928474426, 12.183750033378601 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 9309 139 170 D127K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 2.35 -1.01 2.58 Yes MOPS 50 mM 25.0 Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 3.0 1FTG, 1FLV 19.449999928474426, 12.183750033378601 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 1673 937 170 V140A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 29.0 -6.4 yes 3.0 37.75 MOPS 50 mM NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 6.0 1FTG, 1FLV 9.058571270533971, 5.1814285687037875 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 1691 937 170 V140A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 50.8 -1.5 yes 3.0 54.35 MOPS 50 mM NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 6.0 1FTG, 1FLV 9.058571270533971, 5.1814285687037875 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 7936 937 170 V140A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.6 yes 3.0 MOPS 50 mM 44.3 NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 6.0 1FTG, 1FLV 9.058571270533971, 5.1814285687037875 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 7954 937 170 V140A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.29 yes 3.0 MOPS 50 mM 44.3 NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 6.0 1FTG, 1FLV 9.058571270533971, 5.1814285687037875 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm khan_protherm_data_mapped.csv 9332 937 170 V140A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.68 1.51 2.1 yes MOPS 50 mM 25.0 NaCl 15 mM CD Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 6.0 1FTG, 1FLV 9.058571270533971, 5.1814285687037875 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 1674 938 170 L144A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 33.3 -1.5 yes 3.0 42.65 MOPS 50 mM NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 8.268749952316284, 2.967500001192093 in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 1692 938 170 L144A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 50.0 -0.1 yes 3.0 55.75 MOPS 50 mM NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 8.268749952316284, 2.967500001192093 in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 7937 938 170 L144A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.15 yes 3.0 MOPS 50 mM 44.3 NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 8.268749952316284, 2.967500001192093 in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm potapov_with_uniprot_mapping.csv 7955 938 170 L144A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.11 yes 3.0 MOPS 50 mM 44.3 NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 8.268749952316284, 2.967500001192093 in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 9333 938 170 L144A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 2.02 0.14 2.43 yes MOPS 50 mM 25.0 NaCl 15 mM CD Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 8.268749952316284, 2.967500001192093 in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm potapov_with_uniprot_mapping.csv 1639 922 170 D151K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 30.4 -0.1 Yes 3.0 44.05 MOPS 50 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 4.0 1FTG, 1FLV 9.953750014305115, 4.864999949932098 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 1647 922 170 D151K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 44.7 0.6 Yes 3.0 56.45 MOPS 50 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 4.0 1FTG, 1FLV 9.953750014305115, 4.864999949932098 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 1652 922 170 D151K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 25.1 -6.2 Yes 3.0 32.65 MOPS 50 mM DSC Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 4.0 1FTG, 1FLV 9.953750014305115, 4.864999949932098 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 1658 922 170 D151K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 48.0 0.9 Yes 3.0 53.75 MOPS 50 mM DSC Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 4.0 1FTG, 1FLV 9.953750014305115, 4.864999949932098 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 7887 922 170 D151K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) -0.01 Yes 3.0 MOPS 50 mM 44.3 CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 4.0 1FTG, 1FLV 9.953750014305115, 4.864999949932098 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm khan_protherm_data_mapped.csv 7895 922 170 D151K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) -0.21 Yes 3.0 MOPS 50 mM 44.3 CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 4.0 1FTG, 1FLV 9.953750014305115, 4.864999949932098 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm potapov_with_uniprot_mapping.csv 7903 922 170 D151K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) -0.22 Yes 3.0 MOPS 50 mM 44.3 CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 4.0 1FTG, 1FLV 9.953750014305115, 4.864999949932098 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm potapov_with_uniprot_mapping.csv 7909 922 170 D151K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) -0.6 Yes 3.0 MOPS 50 mM 44.3 DSC Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 4.0 1FTG, 1FLV 9.953750014305115, 4.864999949932098 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 7915 922 170 D151K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.12 Yes 3.0 MOPS 50 mM 44.3 DSC Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 4.0 1FTG, 1FLV 9.953750014305115, 4.864999949932098 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 7921 922 170 D151K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) -0.48 Yes 3.0 MOPS 50 mM 44.3 DSC Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 4.0 1FTG, 1FLV 9.953750014305115, 4.864999949932098 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 9310 922 170 D151K Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 2.12 0.28 2.25 Yes MOPS 50 mM 25.0 Fluorescence Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 4.0 1FTG, 1FLV 9.953750014305115, 4.864999949932098 15504413 10.1016/j.jmb.2004.09.047 2004 ProTherm 1675 939 170 I157V Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 25.3 -8.4 yes 3.0 35.65 MOPS 50 mM NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 7.626249819993973, 3.6249999403953552 in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 1693 939 170 I157V Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 29.9 -8.7 yes 3.0 47.15 MOPS 50 mM NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 7.626249819993973, 3.6249999403953552 in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 7938 939 170 I157V Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.69 yes 3.0 MOPS 50 mM 44.3 NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 7.626249819993973, 3.6249999403953552 in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm khan_protherm_data_mapped.csv 7956 939 170 I157V Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.6 yes 3.0 MOPS 50 mM 44.3 NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 7.626249819993973, 3.6249999403953552 in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 9334 939 170 I157V Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.99 3.6 1.47 yes MOPS 50 mM 25.0 NaCl 15 mM CD Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 7.0 1FTG, 1FLV 7.626249819993973, 3.6249999403953552 in pocket 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 1676 940 170 V161A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 27.7 -8.2 yes 3.0 35.95 MOPS 50 mM NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 5.0 1FTG, 1FLV 6.808571543012347, 2.301428590502058 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 1694 940 170 V161A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 49.2 -6.6 yes 3.0 49.25 MOPS 50 mM NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 5.0 1FTG, 1FLV 6.808571543012347, 2.301428590502058 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 7939 940 170 V161A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 0.73 yes 3.0 MOPS 50 mM 44.3 NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 5.0 1FTG, 1FLV 6.808571543012347, 2.301428590502058 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm khan_protherm_data_mapped.csv 7957 940 170 V161A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.1 yes 3.0 MOPS 50 mM 44.3 NaCl 15 mM CD Thermal 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 5.0 1FTG, 1FLV 6.808571543012347, 2.301428590502058 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 9335 940 170 V161A Flavodoxin, Flavodoxin Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576), Nostoc sp. (strain ATCC 29151 / PCC 7119) 1.23 2.46 2.1 yes MOPS 50 mM 25.0 NaCl 15 mM CD Urea 7.0 P0A3D9, P0A3E0 IPR050619:Flavodoxin, IPR008254:Flavodoxin/NO_synth, IPR001226:Flavodoxin_CS, IPR010086:Flavodoxin_lc, IPR029039:Flavoprotein-like_sf 5.0 1FTG, 1FLV 6.808571543012347, 2.301428590502058 15504414 10.1016/j.jmb.2004.08.081 2004 ProTherm 22133 160 196 Elongation factor Ts Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) No 115.0 Phosphate 10 mM CD Thermal 7.0 P43895 IPR036402:EF-Ts_dimer_sf, IPR001816:Transl_elong_EFTs/EF1B, IPR014039:Transl_elong_EFTs/EF1B_dimer, IPR018101:Transl_elong_Ts_CS, IPR009060:UBA-like_sf 16781902 10.1016/j.bbapap.2006.04.011 2006 ProTherm 22320 160 196 Elongation factor Ts Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) yes 102.2 sodium phosphate 10 mM DSC Thermal 7.0 P43895 IPR036402:EF-Ts_dimer_sf, IPR001816:Transl_elong_EFTs/EF1B, IPR014039:Transl_elong_EFTs/EF1B_dimer, IPR018101:Transl_elong_Ts_CS, IPR009060:UBA-like_sf 11583157 10.1021/bi010274e 2001 ProTherm 264 140 196 C190A Elongation factor Ts Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) -10.0 No 105.0 Phosphate 10 mM CD Thermal 7.0 P43895 IPR036402:EF-Ts_dimer_sf, IPR001816:Transl_elong_EFTs/EF1B, IPR014039:Transl_elong_EFTs/EF1B_dimer, IPR018101:Transl_elong_Ts_CS, IPR009060:UBA-like_sf 4.0 1TFE 18.728333473205566, 18.728333473205566 16781902 10.1016/j.bbapap.2006.04.011 2006 ProTherm 24162 162 302 Dermatophagoides pteronyssinus Unknown 58.0 Polybuffer (mix of Tris, phosphate, citrate, acetate and KCl) 50 mM Fluorescence Thermal 7.0 Q3HWZ5 IPR038765:Papain-like_cys_pep_sf, IPR025661:Pept_asp_AS, IPR000169:Pept_cys_AS, IPR025660:Pept_his_AS, IPR013128:Peptidase_C1A, IPR000668:Peptidase_C1A_C, IPR039417:Peptidase_C1A_papain-like, IPR013201:Prot_inhib_I29 20682463 10.1016/j.bbagen.2010.05.011 2010 ProTherm 24163 162 302 Dermatophagoides pteronyssinus Unknown 39.0 Polybuffer (mix of Tris, phosphate, citrate, acetate and KCl) 50 mM Fluorescence Thermal 4.0 Q3HWZ5 IPR038765:Papain-like_cys_pep_sf, IPR025661:Pept_asp_AS, IPR000169:Pept_cys_AS, IPR025660:Pept_his_AS, IPR013128:Peptidase_C1A, IPR000668:Peptidase_C1A_C, IPR039417:Peptidase_C1A_papain-like, IPR013201:Prot_inhib_I29 20682463 10.1016/j.bbagen.2010.05.011 2010 ProTherm 265 141 302 C114A Dermatophagoides pteronyssinus Unknown 61.4 Polybuffer (mix of Tris, phosphate, citrate, acetate and KCl) 50 mM Fluorescence Thermal 7.0 Q3HWZ5 IPR038765:Papain-like_cys_pep_sf, IPR025661:Pept_asp_AS, IPR000169:Pept_cys_AS, IPR025660:Pept_his_AS, IPR013128:Peptidase_C1A, IPR000668:Peptidase_C1A_C, IPR039417:Peptidase_C1A_papain-like, IPR013201:Prot_inhib_I29 9.0 20682463 10.1016/j.bbagen.2010.05.011 2010 ProTherm 22223 164 636 Iron transport multicopper oxidase FET3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) No 3.0 54.3 Phosphate 50 mM DSC Thermal 7.0 1.16.3.1 P38993 IPR011707:Cu-oxidase-like_N, IPR001117:Cu-oxidase_2nd, IPR011706:Cu-oxidase_C, IPR045087:Cu-oxidase_fam, IPR033138:Cu_oxidase_CS, IPR002355:Cu_oxidase_Cu_BS, IPR008972:Cupredoxin, IPR044130:CuRO_2_Fet3-like 20662012 10.1002/pro.457 2010 ProTherm 22224 164 636 Iron transport multicopper oxidase FET3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 353.73 No 3.0 67.6 Phosphate 50 mM DSC Thermal 7.0 1.16.3.1 P38993 IPR011707:Cu-oxidase-like_N, IPR001117:Cu-oxidase_2nd, IPR011706:Cu-oxidase_C, IPR045087:Cu-oxidase_fam, IPR033138:Cu_oxidase_CS, IPR002355:Cu_oxidase_Cu_BS, IPR008972:Cupredoxin, IPR044130:CuRO_2_Fet3-like 20662012 10.1002/pro.457 2010 ProTherm 266 142 636 N77A Iron transport multicopper oxidase FET3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 322.66 No 3.0 57.0 Phosphate 50 mM DSC Thermal 7.0 1.16.3.1 P38993 IPR011707:Cu-oxidase-like_N, IPR001117:Cu-oxidase_2nd, IPR011706:Cu-oxidase_C, IPR045087:Cu-oxidase_fam, IPR033138:Cu_oxidase_CS, IPR002355:Cu_oxidase_Cu_BS, IPR008972:Cupredoxin, IPR044130:CuRO_2_Fet3-like 5.0 20662012 10.1002/pro.457 2010 ProTherm 267 142 636 N77A Iron transport multicopper oxidase FET3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) No 73.6 Phosphate 50 mM DSC Thermal 7.0 1.16.3.1 P38993 IPR011707:Cu-oxidase-like_N, IPR001117:Cu-oxidase_2nd, IPR011706:Cu-oxidase_C, IPR045087:Cu-oxidase_fam, IPR033138:Cu_oxidase_CS, IPR002355:Cu_oxidase_Cu_BS, IPR008972:Cupredoxin, IPR044130:CuRO_2_Fet3-like 5.0 20662012 10.1002/pro.457 2010 ProTherm 268 143 636 N113A Iron transport multicopper oxidase FET3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) No 4.0 52.3 Phosphate 50 mM DSC Thermal 7.0 1.16.3.1 P38993 IPR011707:Cu-oxidase-like_N, IPR001117:Cu-oxidase_2nd, IPR011706:Cu-oxidase_C, IPR045087:Cu-oxidase_fam, IPR033138:Cu_oxidase_CS, IPR002355:Cu_oxidase_Cu_BS, IPR008972:Cupredoxin, IPR044130:CuRO_2_Fet3-like 6.0 20662012 10.1002/pro.457 2010 ProTherm 269 143 636 N113A Iron transport multicopper oxidase FET3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 262.91 No 4.0 54.5 Phosphate 50 mM DSC Thermal 7.0 1.16.3.1 P38993 IPR011707:Cu-oxidase-like_N, IPR001117:Cu-oxidase_2nd, IPR011706:Cu-oxidase_C, IPR045087:Cu-oxidase_fam, IPR033138:Cu_oxidase_CS, IPR002355:Cu_oxidase_Cu_BS, IPR008972:Cupredoxin, IPR044130:CuRO_2_Fet3-like 6.0 20662012 10.1002/pro.457 2010 ProTherm 270 143 636 N113A Iron transport multicopper oxidase FET3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) No 4.0 65.7 Phosphate 50 mM DSC Thermal 7.0 1.16.3.1 P38993 IPR011707:Cu-oxidase-like_N, IPR001117:Cu-oxidase_2nd, IPR011706:Cu-oxidase_C, IPR045087:Cu-oxidase_fam, IPR033138:Cu_oxidase_CS, IPR002355:Cu_oxidase_Cu_BS, IPR008972:Cupredoxin, IPR044130:CuRO_2_Fet3-like 6.0 20662012 10.1002/pro.457 2010 ProTherm 271 144 636 N198A Iron transport multicopper oxidase FET3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 293.98 No 3.0 56.1 Phosphate 50 mM DSC Thermal 7.0 1.16.3.1 P38993 IPR011707:Cu-oxidase-like_N, IPR001117:Cu-oxidase_2nd, IPR011706:Cu-oxidase_C, IPR045087:Cu-oxidase_fam, IPR033138:Cu_oxidase_CS, IPR002355:Cu_oxidase_Cu_BS, IPR008972:Cupredoxin, IPR044130:CuRO_2_Fet3-like 6.0 20662012 10.1002/pro.457 2010 ProTherm 272 144 636 N198A Iron transport multicopper oxidase FET3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) No 3.0 66.2 Phosphate 50 mM DSC Thermal 7.0 1.16.3.1 P38993 IPR011707:Cu-oxidase-like_N, IPR001117:Cu-oxidase_2nd, IPR011706:Cu-oxidase_C, IPR045087:Cu-oxidase_fam, IPR033138:Cu_oxidase_CS, IPR002355:Cu_oxidase_Cu_BS, IPR008972:Cupredoxin, IPR044130:CuRO_2_Fet3-like 6.0 20662012 10.1002/pro.457 2010 ProTherm 22225 168 1480 Cystic fibrosis transmembrane conductance regulator Homo sapiens No 57.7 HEPES 20 mM NaCl 150 mM DSC Thermal 7.5 P13569 IPR003593:AAA+_ATPase, IPR011527:ABC1_TM_dom, IPR036640:ABC1_TM_sf, IPR003439:ABC_transporter-like_ATP-bd, IPR017871:ABC_transporter-like_CS, IPR050173:ABC_transporter_C-like, IPR009147:CFTR/ABCC7, IPR047082:CFTR1_ATP-bd_dom1, IPR025837:CFTR_reg_dom, IPR027417:P-loop_NTPase 20687133 10.1002/pro.479 2010 ProTherm 22226 168 1480 Cystic fibrosis transmembrane conductance regulator Homo sapiens No 51.5 HEPES 20 mM NaCl 150 mM DSC Thermal 7.5 P13569 IPR003593:AAA+_ATPase, IPR011527:ABC1_TM_dom, IPR036640:ABC1_TM_sf, IPR003439:ABC_transporter-like_ATP-bd, IPR017871:ABC_transporter-like_CS, IPR050173:ABC_transporter_C-like, IPR009147:CFTR/ABCC7, IPR047082:CFTR1_ATP-bd_dom1, IPR025837:CFTR_reg_dom, IPR027417:P-loop_NTPase 20687133 10.1002/pro.479 2010 ProTherm 22227 168 1480 Cystic fibrosis transmembrane conductance regulator Homo sapiens No 58.1 HEPES 20 mM NaCl 150 mM DSC Thermal 7.5 P13569 IPR003593:AAA+_ATPase, IPR011527:ABC1_TM_dom, IPR036640:ABC1_TM_sf, IPR003439:ABC_transporter-like_ATP-bd, IPR017871:ABC_transporter-like_CS, IPR050173:ABC_transporter_C-like, IPR009147:CFTR/ABCC7, IPR047082:CFTR1_ATP-bd_dom1, IPR025837:CFTR_reg_dom, IPR027417:P-loop_NTPase 20687133 10.1002/pro.479 2010 ProTherm 22228 168 1480 Cystic fibrosis transmembrane conductance regulator Homo sapiens No 51.7 HEPES 20 mM NaCl 150 mM DSC Thermal 7.5 P13569 IPR003593:AAA+_ATPase, IPR011527:ABC1_TM_dom, IPR036640:ABC1_TM_sf, IPR003439:ABC_transporter-like_ATP-bd, IPR017871:ABC_transporter-like_CS, IPR050173:ABC_transporter_C-like, IPR009147:CFTR/ABCC7, IPR047082:CFTR1_ATP-bd_dom1, IPR025837:CFTR_reg_dom, IPR027417:P-loop_NTPase 20687133 10.1002/pro.479 2010 ProTherm 22229 168 1480 Cystic fibrosis transmembrane conductance regulator Homo sapiens No 57.8 HEPES 20 mM NaCl 150 mM DSC Thermal 7.5 P13569 IPR003593:AAA+_ATPase, IPR011527:ABC1_TM_dom, IPR036640:ABC1_TM_sf, IPR003439:ABC_transporter-like_ATP-bd, IPR017871:ABC_transporter-like_CS, IPR050173:ABC_transporter_C-like, IPR009147:CFTR/ABCC7, IPR047082:CFTR1_ATP-bd_dom1, IPR025837:CFTR_reg_dom, IPR027417:P-loop_NTPase 20687133 10.1002/pro.479 2010 ProTherm 22230 168 1480 Cystic fibrosis transmembrane conductance regulator Homo sapiens No 57.9 HEPES 20 mM NaCl 150 mM DSC Thermal 7.5 P13569 IPR003593:AAA+_ATPase, IPR011527:ABC1_TM_dom, IPR036640:ABC1_TM_sf, IPR003439:ABC_transporter-like_ATP-bd, IPR017871:ABC_transporter-like_CS, IPR050173:ABC_transporter_C-like, IPR009147:CFTR/ABCC7, IPR047082:CFTR1_ATP-bd_dom1, IPR025837:CFTR_reg_dom, IPR027417:P-loop_NTPase 20687133 10.1002/pro.479 2010 ProTherm 15656 7299 1480 F494N, Q637R Cystic fibrosis transmembrane conductance regulator Homo sapiens No 59.2 HEPES 20 mM NaCl 150 mM DSC Thermal 7.5 P13569 IPR003593:AAA+_ATPase, IPR011527:ABC1_TM_dom, IPR036640:ABC1_TM_sf, IPR003439:ABC_transporter-like_ATP-bd, IPR017871:ABC_transporter-like_CS, IPR050173:ABC_transporter_C-like, IPR009147:CFTR/ABCC7, IPR047082:CFTR1_ATP-bd_dom1, IPR025837:CFTR_reg_dom, IPR027417:P-loop_NTPase 7.0, 8.0 20687133 10.1002/pro.479 2010 ProTherm 15657 7299 1480 F494N, Q637R Cystic fibrosis transmembrane conductance regulator Homo sapiens No 52.8 HEPES 20 mM NaCl 150 mM DSC Thermal 7.5 P13569 IPR003593:AAA+_ATPase, IPR011527:ABC1_TM_dom, IPR036640:ABC1_TM_sf, IPR003439:ABC_transporter-like_ATP-bd, IPR017871:ABC_transporter-like_CS, IPR050173:ABC_transporter_C-like, IPR009147:CFTR/ABCC7, IPR047082:CFTR1_ATP-bd_dom1, IPR025837:CFTR_reg_dom, IPR027417:P-loop_NTPase 7.0, 8.0 20687133 10.1002/pro.479 2010 ProTherm 273 145 1480 V510D Cystic fibrosis transmembrane conductance regulator Homo sapiens No 60.2 HEPES 20 mM NaCl 150 mM DSC Thermal 7.5 P13569 IPR003593:AAA+_ATPase, IPR011527:ABC1_TM_dom, IPR036640:ABC1_TM_sf, IPR003439:ABC_transporter-like_ATP-bd, IPR017871:ABC_transporter-like_CS, IPR050173:ABC_transporter_C-like, IPR009147:CFTR/ABCC7, IPR047082:CFTR1_ATP-bd_dom1, IPR025837:CFTR_reg_dom, IPR027417:P-loop_NTPase 7.0 20687133 10.1002/pro.479 2010 ProTherm 274 145 1480 V510D Cystic fibrosis transmembrane conductance regulator Homo sapiens No 53.0 HEPES 20 mM NaCl 150 mM DSC Thermal 7.5 P13569 IPR003593:AAA+_ATPase, IPR011527:ABC1_TM_dom, IPR036640:ABC1_TM_sf, IPR003439:ABC_transporter-like_ATP-bd, IPR017871:ABC_transporter-like_CS, IPR050173:ABC_transporter_C-like, IPR009147:CFTR/ABCC7, IPR047082:CFTR1_ATP-bd_dom1, IPR025837:CFTR_reg_dom, IPR027417:P-loop_NTPase 7.0 20687133 10.1002/pro.479 2010 ProTherm 20894 170 296 Ribose import binding protein RbsB Escherichia coli (strain K12) 5.1 yes HEPES 10 mM 25.0 Fluorescence GdnHCl 7.7 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 1904869 1991 ProTherm 22231 170 296 Ribose import binding protein RbsB Escherichia coli (strain K12) Unknown 62.6 MOPS 25 mM Potassium chloride 100 mM Activity Thermal 7.6 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 20194783 10.1073/pnas.0910421107 2010 ProTherm 23503 170 296 Ribose import binding protein RbsB Escherichia coli (strain K12) Unknown 57.5 Phosphate 5 mM CD Thermal 7.0 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 17242374 10.1110/ps.062595707 2007 ProTherm 23504 170 296 Ribose import binding protein RbsB Escherichia coli (strain K12) Unknown 63.7 Phosphate 5 mM CD Thermal 7.0 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 17242374 10.1110/ps.062595707 2007 ProTherm 24057 170 296 Ribose import binding protein RbsB Escherichia coli (strain K12) Unknown 62.6 MOPS 25 mM Potassium chloride 100 mM Quantitative cysteine reactivity Thermal 7.6 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 20194783 10.1073/pnas.0910421107 2010 ProTherm 2575 1310 296 S34A Ribose import binding protein RbsB Escherichia coli (strain K12) -1.5 Unknown 56.0 Phosphate 5 mM CD Thermal 7.0 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 8.0 2DRI 8.1875 in pocket 17242374 10.1110/ps.062595707 2007 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 2588 1310 296 S34A Ribose import binding protein RbsB Escherichia coli (strain K12) 0.1 Unknown 63.8 Phosphate 5 mM CD Thermal 7.0 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 8.0 2DRI 8.1875 in pocket 17242374 10.1110/ps.062595707 2007 ProTherm STRUM_Q3421.csv 16012 7521 296 S34A, I157A Ribose import binding protein RbsB Escherichia coli (strain K12) -0.7 Unknown 56.8 Phosphate 5 mM CD Thermal 7.0 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 8.0, 5.0 2DRI 8.1875, 12.236666679382324 in pocket 17242374 10.1110/ps.062595707 2007 ProTherm 16016 7521 296 S34A, I157A Ribose import binding protein RbsB Escherichia coli (strain K12) 2.4 Unknown 66.1 Phosphate 5 mM CD Thermal 7.0 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 8.0, 5.0 2DRI 8.1875, 12.236666679382324 in pocket 17242374 10.1110/ps.062595707 2007 ProTherm 16013 7522 296 S34A, I157A, S128A Ribose import binding protein RbsB Escherichia coli (strain K12) -4.1 Unknown 53.4 Phosphate 5 mM CD Thermal 7.0 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 8.0, 9.0, 5.0 2DRI 8.1875, 10.206249952316284, 12.236666679382324 in pocket 17242374 10.1110/ps.062595707 2007 ProTherm 16017 7522 296 S34A, I157A, S128A Ribose import binding protein RbsB Escherichia coli (strain K12) -10.0 Unknown 53.7 Phosphate 5 mM CD Thermal 7.0 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 8.0, 9.0, 5.0 2DRI 8.1875, 10.206249952316284, 12.236666679382324 in pocket 17242374 10.1110/ps.062595707 2007 ProTherm 16014 7523 296 S34A, I157A, S128A, N38A Ribose import binding protein RbsB Escherichia coli (strain K12) -3.4 Unknown 54.1 Phosphate 5 mM CD Thermal 7.0 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 8.0, 9.0, 9.0, 5.0 2DRI 8.1875, 8.972727168690074, 10.206249952316284, 12.236666679382324 in pocket 17242374 10.1110/ps.062595707 2007 ProTherm 16018 7523 296 S34A, I157A, S128A, N38A Ribose import binding protein RbsB Escherichia coli (strain K12) -9.0 Unknown 54.7 Phosphate 5 mM CD Thermal 7.0 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 8.0, 9.0, 9.0, 5.0 2DRI 8.1875, 8.972727168690074, 10.206249952316284, 12.236666679382324 in pocket 17242374 10.1110/ps.062595707 2007 ProTherm 16015 7524 296 S34A, I157A, S128A, N38A, Q260A Ribose import binding protein RbsB Escherichia coli (strain K12) 1.4 Unknown 58.9 Phosphate 5 mM CD Thermal 7.0 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 8.0, 9.0, 9.0, 5.0, 9.0 2DRI 8.1875, 8.972727168690074, 10.206249952316284, 12.236666679382324, 9.492499987284342 in pocket 17242374 10.1110/ps.062595707 2007 ProTherm 16019 7524 296 S34A, I157A, S128A, N38A, Q260A Ribose import binding protein RbsB Escherichia coli (strain K12) -4.7 Unknown 59.0 Phosphate 5 mM CD Thermal 7.0 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 8.0, 9.0, 9.0, 5.0, 9.0 2DRI 8.1875, 8.972727168690074, 10.206249952316284, 12.236666679382324, 9.492499987284342 in pocket 17242374 10.1110/ps.062595707 2007 ProTherm 2576 1311 296 N38A Ribose import binding protein RbsB Escherichia coli (strain K12) 0.7 Unknown 58.2 Phosphate 5 mM CD Thermal 7.0 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 9.0 2DRI 8.972727168690074 in pocket 17242374 10.1110/ps.062595707 2007 ProTherm Broom_S605.csv, STRUM_Q3421.csv, EASE-MM_S543.csv, PoPMuSiC-2.0_S2648.csv, HotMuSiC_S1626.csv 2589 1311 296 N38A Ribose import binding protein RbsB Escherichia coli (strain K12) -3.6 Unknown 60.1 Phosphate 5 mM CD Thermal 7.0 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 9.0 2DRI 8.972727168690074 in pocket 17242374 10.1110/ps.062595707 2007 ProTherm STRUM_Q3421.csv, Broom_S605.csv 2577 1312 296 F40A Ribose import binding protein RbsB Escherichia coli (strain K12) -5.0 Unknown 52.5 Phosphate 5 mM CD Thermal 7.0 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 8.0 2DRI 11.81333327293396 in pocket 17242374 10.1110/ps.062595707 2007 ProTherm EASE-MM_S543.csv, HotMuSiC_S1626.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv 2590 1312 296 F40A Ribose import binding protein RbsB Escherichia coli (strain K12) -9.5 Unknown 54.2 Phosphate 5 mM CD Thermal 7.0 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 8.0 2DRI 11.81333327293396 in pocket 17242374 10.1110/ps.062595707 2007 ProTherm STRUM_Q3421.csv 2578 1313 296 F41A Ribose import binding protein RbsB Escherichia coli (strain K12) 1.4 Unknown 58.9 Phosphate 5 mM CD Thermal 7.0 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 8.0 2DRI 10.058333357175192 in pocket 17242374 10.1110/ps.062595707 2007 ProTherm EASE-MM_S543.csv, HotMuSiC_S1626.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv 2591 1313 296 F41A Ribose import binding protein RbsB Escherichia coli (strain K12) -6.3 Unknown 57.4 Phosphate 5 mM CD Thermal 7.0 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 8.0 2DRI 10.058333357175192 in pocket 17242374 10.1110/ps.062595707 2007 ProTherm STRUM_Q3421.csv 10819 4606 296 A52T Ribose import binding protein RbsB Escherichia coli (strain K12) 1.8 yes HEPES 10 mM 25.0 Fluorescence GdnHCl 7.7 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 9.0 2DRI 20.241666475931805 1904869 1991 ProTherm 10818 4605 296 V75E Ribose import binding protein RbsB Escherichia coli (strain K12) 1.6 yes HEPES 10 mM 25.0 Fluorescence GdnHCl 7.7 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 6.0 2DRI 13.587499976158142 in pocket 1904869 1991 ProTherm 275 146 296 L87C Ribose import binding protein RbsB Escherichia coli (strain K12) -8.6 Unknown 54.0 MOPS 25 mM Potassium chloride 100 mM Activity Thermal 7.6 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 6.0 2DRI 11.779999944898817 in pocket 20194783 10.1073/pnas.0910421107 2010 ProTherm 2896 146 296 L87C Ribose import binding protein RbsB Escherichia coli (strain K12) -8.6 Unknown 54.0 MOPS 25 mM Potassium chloride 100 mM Quantitative cysteine reactivity Thermal 7.6 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 6.0 2DRI 11.779999944898817 in pocket 20194783 10.1073/pnas.0910421107 2010 ProTherm Broom_S605.csv, STRUM_Q3421.csv 8647 146 296 L87C Ribose import binding protein RbsB Escherichia coli (strain K12) 2.7 3.2 81.0 Unknown MOPS 25 mM 25.0 Potassium chloride 100 mM Activity Thermal 7.6 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 6.0 2DRI 11.779999944898817 in pocket 20194783 10.1073/pnas.0910421107 2010 ProTherm 10503 146 296 L87C Ribose import binding protein RbsB Escherichia coli (strain K12) 3.2 81.0 Unknown MOPS 25 mM 25.0 Potassium chloride 100 mM Quantitative cysteine reactivity Thermal 7.6 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 6.0 2DRI 11.779999944898817 in pocket 20194783 10.1073/pnas.0910421107 2010 ProTherm 2579 1314 296 N89A Ribose import binding protein RbsB Escherichia coli (strain K12) -4.6 Unknown 52.9 Phosphate 5 mM CD Thermal 7.0 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 8.0 2DRI 8.344545451077549 in pocket 17242374 10.1110/ps.062595707 2007 ProTherm EASE-MM_S543.csv, HotMuSiC_S1626.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv 2592 1314 296 N89A Ribose import binding protein RbsB Escherichia coli (strain K12) -9.8 Unknown 53.9 Phosphate 5 mM CD Thermal 7.0 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 8.0 2DRI 8.344545451077549 in pocket 17242374 10.1110/ps.062595707 2007 ProTherm AUTOMUTE_S1925.csv, AUTOMUTE_S1962.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, M47andM8_S1810.csv, M47andM8_S2760.csv, Saraboji_S2204.csv, SVM-WIN31_SVM-3D12_S1634.csv, SVM-WIN31_SVM-3D12_S1681.csv 2580 1315 296 D114A Ribose import binding protein RbsB Escherichia coli (strain K12) 0.7 Unknown 58.2 Phosphate 5 mM CD Thermal 7.0 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 9.0 2DRI 9.814444435967339 in pocket 17242374 10.1110/ps.062595707 2007 ProTherm EASE-MM_S543.csv, HotMuSiC_S1626.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv 2593 1315 296 D114A Ribose import binding protein RbsB Escherichia coli (strain K12) -6.5 Unknown 57.2 Phosphate 5 mM CD Thermal 7.0 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 9.0 2DRI 9.814444435967339 in pocket 17242374 10.1110/ps.062595707 2007 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv 2581 1316 296 S128A Ribose import binding protein RbsB Escherichia coli (strain K12) 0.3 Unknown 57.8 Phosphate 5 mM CD Thermal 7.0 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 9.0 2DRI 10.206249952316284 17242374 10.1110/ps.062595707 2007 ProTherm EASE-MM_S543.csv, HotMuSiC_S1626.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv 2594 1316 296 S128A Ribose import binding protein RbsB Escherichia coli (strain K12) -3.0 Unknown 60.7 Phosphate 5 mM CD Thermal 7.0 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 9.0 2DRI 10.206249952316284 17242374 10.1110/ps.062595707 2007 ProTherm Broom_S605.csv 2582 1317 296 I157A Ribose import binding protein RbsB Escherichia coli (strain K12) -0.2 Unknown 57.3 Phosphate 5 mM CD Thermal 7.0 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 5.0 2DRI 12.236666679382324 in pocket 17242374 10.1110/ps.062595707 2007 ProTherm EASE-MM_S543.csv, HotMuSiC_S1626.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv 2595 1317 296 I157A Ribose import binding protein RbsB Escherichia coli (strain K12) -2.5 Unknown 61.2 Phosphate 5 mM CD Thermal 7.0 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 5.0 2DRI 12.236666679382324 in pocket 17242374 10.1110/ps.062595707 2007 ProTherm Broom_S605.csv, EASE-MM_S543.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv 2583 1318 296 F189A Ribose import binding protein RbsB Escherichia coli (strain K12) -5.8 Unknown 51.7 Phosphate 5 mM CD Thermal 7.0 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 8.0 2DRI 9.11916677157084 in pocket 17242374 10.1110/ps.062595707 2007 ProTherm EASE-MM_S543.csv, HotMuSiC_S1626.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv 2596 1318 296 F189A Ribose import binding protein RbsB Escherichia coli (strain K12) -10.4 Unknown 53.3 Phosphate 5 mM CD Thermal 7.0 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 8.0 2DRI 9.11916677157084 in pocket 17242374 10.1110/ps.062595707 2007 ProTherm 276 147 296 A213C Ribose import binding protein RbsB Escherichia coli (strain K12) -6.6 Unknown 56.0 MOPS 25 mM Potassium chloride 100 mM Activity Thermal 7.6 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 8.0 2DRI 8.608333428700766 20194783 10.1073/pnas.0910421107 2010 ProTherm 2897 147 296 A213C Ribose import binding protein RbsB Escherichia coli (strain K12) -6.6 Unknown 56.0 MOPS 25 mM Potassium chloride 100 mM Quantitative cysteine reactivity Thermal 7.6 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 8.0 2DRI 8.608333428700766 20194783 10.1073/pnas.0910421107 2010 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv 8648 147 296 A213C Ribose import binding protein RbsB Escherichia coli (strain K12) 1.8 4.1 91.0 Unknown MOPS 25 mM 25.0 Potassium chloride 100 mM Activity Thermal 7.6 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 8.0 2DRI 8.608333428700766 20194783 10.1073/pnas.0910421107 2010 ProTherm 10504 147 296 A213C Ribose import binding protein RbsB Escherichia coli (strain K12) 4.1 91.0 Unknown MOPS 25 mM 25.0 Potassium chloride 100 mM Quantitative cysteine reactivity Thermal 7.6 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 8.0 2DRI 8.608333428700766 20194783 10.1073/pnas.0910421107 2010 ProTherm 2584 1319 296 N215A Ribose import binding protein RbsB Escherichia coli (strain K12) -8.1 Unknown 49.4 Phosphate 5 mM CD Thermal 7.0 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 9.0 2DRI 7.475454590537331 in pocket 17242374 10.1110/ps.062595707 2007 ProTherm EASE-MM_S543.csv, HotMuSiC_S1626.csv, PoPMuSiC-2.0_S2648.csv, STRUM_Q3421.csv 2597 1319 296 N215A Ribose import binding protein RbsB Escherichia coli (strain K12) -12.2 Unknown 51.5 Phosphate 5 mM CD Thermal 7.0 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 9.0 2DRI 7.475454590537331 in pocket 17242374 10.1110/ps.062595707 2007 ProTherm Broom_S605.csv, STRUM_Q3421.csv 2585 1320 296 F239A Ribose import binding protein RbsB Escherichia coli (strain K12) -9.5 Unknown 48.0 Phosphate 5 mM CD Thermal 7.0 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 8.0 2DRI 10.619166692097982 17242374 10.1110/ps.062595707 2007 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, Broom_S605.csv 2598 1320 296 F239A Ribose import binding protein RbsB Escherichia coli (strain K12) -17.7 Unknown 46.0 Phosphate 5 mM CD Thermal 7.0 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 8.0 2DRI 10.619166692097982 17242374 10.1110/ps.062595707 2007 ProTherm Broom_S605.csv, STRUM_Q3421.csv 2586 1321 296 D240A Ribose import binding protein RbsB Escherichia coli (strain K12) -6.3 Unknown 51.2 Phosphate 5 mM CD Thermal 7.0 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 9.0 2DRI 10.255555470784506 in pocket 17242374 10.1110/ps.062595707 2007 ProTherm Broom_S605.csv, STRUM_Q3421.csv 2599 1321 296 D240A Ribose import binding protein RbsB Escherichia coli (strain K12) -12.4 Unknown 51.3 Phosphate 5 mM CD Thermal 7.0 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 9.0 2DRI 10.255555470784506 in pocket 17242374 10.1110/ps.062595707 2007 ProTherm 2587 1322 296 Q260A Ribose import binding protein RbsB Escherichia coli (strain K12) 0.7 Unknown 58.2 Phosphate 5 mM CD Thermal 7.0 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 9.0 2DRI 9.492499987284342 in pocket 17242374 10.1110/ps.062595707 2007 ProTherm 2600 1322 296 Q260A Ribose import binding protein RbsB Escherichia coli (strain K12) -4.8 Unknown 58.9 Phosphate 5 mM CD Thermal 7.0 P02925 IPR028082:Peripla_BP_I, IPR025997:SBP_2_dom 9.0 2DRI 9.492499987284342 in pocket 17242374 10.1110/ps.062595707 2007 ProTherm STRUM_Q3421.csv 21727 175 3685 Dystrophin Homo sapiens 1.5 Unknown Sodium phosphate 0.05 M 20.0 NaCl 0.15 M CD Urea 7.6 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7794924 10.1021/bi00025a017 1995 ProTherm 21728 175 3685 Dystrophin Homo sapiens 3.4 Unknown Sodium phosphate 0.05 M 20.0 NaCl 0.15 M CD Urea 7.6 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7794924 10.1021/bi00025a017 1995 ProTherm 22232 175 3685 Dystrophin Homo sapiens Unknown 58.0 Phosphate 100 mM NaCl 150 mM CD Thermal 7.0 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 20696926 10.1073/pnas.1008818107 2010 ProTherm 24222 175 3685 Dystrophin Homo sapiens 53.4 Tris-HCl 20000.0 NaCl 150000.0 CD Thermal 7.5 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 22453924 10.1074/jbc.M111.284521 2012 ProTherm 24237 175 3685 Dystrophin Homo sapiens 2.0 46.1 PBS CD Thermal 7.5 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 21558423 10.1093/hmg/ddr199 2011 ProTherm 24238 175 3685 Dystrophin Homo sapiens 2.0 50.9 PBS CD Thermal 7.5 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 21558423 10.1093/hmg/ddr199 2011 ProTherm 24239 175 3685 Dystrophin Homo sapiens 2.0 65.5 PBS CD Thermal 7.5 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 21558423 10.1093/hmg/ddr199 2011 ProTherm 24240 175 3685 Dystrophin Homo sapiens 2.0 50.2 PBS CD Thermal 7.5 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 21558423 10.1093/hmg/ddr199 2011 ProTherm 24241 175 3685 Dystrophin Homo sapiens 2.0 69.6 PBS CD Thermal 7.5 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 21558423 10.1093/hmg/ddr199 2011 ProTherm 24246 175 3685 Dystrophin Homo sapiens 60.0 PBS CD Thermal 7.4 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 20886611 10.1002/cm.20489 2010 ProTherm 24247 175 3685 Dystrophin Homo sapiens 65.0 PBS CD Thermal 7.4 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 20886611 10.1002/cm.20489 2010 ProTherm 24248 175 3685 Dystrophin Homo sapiens 55.0 PBS CD Thermal 7.4 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 20886611 10.1002/cm.20489 2010 ProTherm 24249 175 3685 Dystrophin Homo sapiens 55.0 PBS Fluorescence Thermal 7.5 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 20886611 10.1002/cm.20489 2010 ProTherm 24250 175 3685 Dystrophin Homo sapiens 62.0 PBS Fluorescence Thermal 7.5 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 20886611 10.1002/cm.20489 2010 ProTherm 24251 175 3685 Dystrophin Homo sapiens 35.0 PBS Fluorescence Thermal 7.5 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 20886611 10.1002/cm.20489 2010 ProTherm 24380 175 3685 Dystrophin Homo sapiens yes 2.0 61.0 sodium phosphate 0.1 M NaCl 0.15 M CD Thermal 7.0 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 25340340 10.1371/journal.pone.0110439 2014 ProTherm 24381 175 3685 Dystrophin Homo sapiens 11.2 yes 2.0 sodium phosphate 0.1 M NaCl 0.15 M CD Urea 7.0 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 25340340 10.1371/journal.pone.0110439 2014 ProTherm 24382 175 3685 Dystrophin Homo sapiens 11.2 yes 2.0 sodium phosphate 0.1 M NaCl 0.15 M Fluorescence Urea 7.0 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 25340340 10.1371/journal.pone.0110439 2014 ProTherm 24383 175 3685 Dystrophin Homo sapiens no 2.0 61.0 PBS CD Thermal 7.0 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 25340340 10.1371/journal.pone.0110439 2014 ProTherm 24658 175 3685 Dystrophin Homo sapiens 2.0 43.36 PBS Differential Scanning Fluorimetry Thermal 7.5 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 26392559 10.1073/pnas.1508755112 2015 ProTherm 26626 175 3685 Dystrophin Homo sapiens 11.2 yes 2.0 PBS 25.0 Fluorescence Urea 7.0 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 25340340 10.1371/journal.pone.0110439 2014 ProTherm 16210 7653 3685 C10S, C188S Dystrophin Homo sapiens 9.81 -1.68 yes NaH2PO4 100000.0 NaCl 150000.0 CD Urea 7.0 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 1.0, 1.0 1DXX 65.96166610717773, 59.31666692097982, 65.96499951680501, 59.43500010172526 in pocket 22275054 10.1002/prot.24033 2012 ProTherm 16211 7653 3685 C10S, C188S Dystrophin Homo sapiens 12.84 -2.23 yes NaH2PO4 100000.0 NaCl 150000.0 Fluorescence Urea 7.0 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 1.0, 1.0 1DXX 65.96166610717773, 59.31666692097982, 65.96499951680501, 59.43500010172526 in pocket 22275054 10.1002/prot.24033 2012 ProTherm 16212 7653 3685 C10S, C188S Dystrophin Homo sapiens no 61.0 NaH2PO4 100000.0 NaCl 150000.0 CD Thermal 7.0 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 1.0, 1.0 1DXX 65.96166610717773, 59.31666692097982, 65.96499951680501, 59.43500010172526 in pocket 22275054 10.1002/prot.24033 2012 ProTherm 16213 7653 3685 C10S, C188S Dystrophin Homo sapiens no 62.4 NaH2PO4 100000.0 NaCl 150000.0 Fluorescence Thermal 7.0 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 1.0, 1.0 1DXX 65.96166610717773, 59.31666692097982, 65.96499951680501, 59.43500010172526 in pocket 22275054 10.1002/prot.24033 2012 ProTherm 4647 2353 3685 K18N Dystrophin Homo sapiens -3.4 yes 2.0 57.6 sodium phosphate 0.1 M NaCl 0.15 M CD Thermal 7.0 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 28.823333316379124, 28.77000003390842 in pocket 25340340 10.1371/journal.pone.0110439 2014 ProTherm 4648 2353 3685 K18N Dystrophin Homo sapiens 3.7 7.5 yes 2.0 sodium phosphate 0.1 M NaCl 0.15 M CD Urea 7.0 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 28.823333316379124, 28.77000003390842 in pocket 25340340 10.1371/journal.pone.0110439 2014 ProTherm 4649 2353 3685 K18N Dystrophin Homo sapiens 3.7 7.5 yes 2.0 sodium phosphate 0.1 M NaCl 0.15 M Fluorescence Urea 7.0 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 28.823333316379124, 28.77000003390842 in pocket 25340340 10.1371/journal.pone.0110439 2014 ProTherm 4650 2353 3685 K18N Dystrophin Homo sapiens -3.4 no 2.0 57.6 PBS CD Thermal 7.0 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 28.823333316379124, 28.77000003390842 in pocket 25340340 10.1371/journal.pone.0110439 2014 ProTherm 11527 2353 3685 K18N Dystrophin Homo sapiens 3.7 7.5 yes 2.0 PBS 25.0 Fluorescence Urea 7.0 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 28.823333316379124, 28.77000003390842 in pocket 25340340 10.1371/journal.pone.0110439 2014 ProTherm 5218 2827 3685 L54R Dystrophin Homo sapiens -3.33 2.0 40.03 PBS Differential Scanning Fluorimetry Thermal 7.5 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 35.1537504196167, 35.62749981880188 in pocket 26392559 10.1073/pnas.1508755112 2015 ProTherm 5217 2826 3685 L172H Dystrophin Homo sapiens -1.28 2.0 42.08 PBS Differential Scanning Fluorimetry Thermal 7.5 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 35.33875012397766, 35.488749980926514 26392559 10.1073/pnas.1508755112 2015 ProTherm 279 150 3685 Y231N Dystrophin Homo sapiens -15.0 Unknown 43.0 Phosphate 100 mM NaCl 150 mM CD Thermal 7.0 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 23.392500082651775, 23.21750005086263 in pocket 20696926 10.1073/pnas.1008818107 2010 ProTherm 4423 2229 3685 L427P Dystrophin Homo sapiens -3.4 50.0 Tris-HCl 20000.0 NaCl 150000.0 CD Thermal 7.5 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 22453924 10.1074/jbc.M111.284521 2012 ProTherm 3828454 3775242 3685 V3057C Dystrophin Homo sapiens 0.0457282820383199 0.228396183410903 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3828455 3775243 3685 V3057G Dystrophin Homo sapiens 0.236673578912972 0.136730198983126 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3828456 3775244 3685 V3057H Dystrophin Homo sapiens 0.136895046968617 0.276081604153791 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3828457 3775245 3685 V3057I Dystrophin Homo sapiens 0.763319934969492 0.514177290217888 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3828458 3775246 3685 V3057K Dystrophin Homo sapiens 1.96824184851721 1.56367713144867 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3828459 3775247 3685 V3057L Dystrophin Homo sapiens 0.196842256858595 0.0367086052980008 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3828460 3775248 3685 V3057M Dystrophin Homo sapiens 0.704175522784618 0.530650307078843 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3828461 3775249 3685 V3057P Dystrophin Homo sapiens -0.290393485811664 0.216579307718221 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3828462 3775250 3685 V3057R Dystrophin Homo sapiens -0.112674506747359 0.188124606563914 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3828463 3775251 3685 V3057T Dystrophin Homo sapiens -0.0708237448264857 0.0705996451895659 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3828464 3775252 3685 V3057A Dystrophin Homo sapiens -0.392554867001091 0.122659031730634 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3828465 3775253 3685 V3057D Dystrophin Homo sapiens -0.389156193175368 0.154327601873247 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3828466 3775254 3685 V3057E Dystrophin Homo sapiens -0.324015666904079 0.14820161914964 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3828467 3775255 3685 V3057N Dystrophin Homo sapiens -0.0808974820578899 0.128140296171656 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3828468 3775256 3685 V3057Q Dystrophin Homo sapiens 0.267778282186069 0.651334988937715 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3828469 3775257 3685 V3057W Dystrophin Homo sapiens 0.0299548048815493 0.267475064068246 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3828470 3775258 3685 V3057Y Dystrophin Homo sapiens 0.39148276713627 0.33749509971232 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3828471 3775259 3685 V3057F Dystrophin Homo sapiens 0.228410429463644 0.28805964253791 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3828674 3775462 3685 Q3058A Dystrophin Homo sapiens -0.080937175206736 0.233897927959341 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3828675 3775463 3685 Q3058C Dystrophin Homo sapiens 1.5437607896267 0.603731342338011 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3828676 3775464 3685 Q3058D Dystrophin Homo sapiens 0.137024352965496 0.232737977435949 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3828677 3775465 3685 Q3058E Dystrophin Homo sapiens 0.317738626509068 0.234012762847353 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3828678 3775466 3685 Q3058F Dystrophin Homo sapiens 0.895427599290278 1.05343656798843 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3828679 3775467 3685 Q3058G Dystrophin Homo sapiens 0.152850772325218 0.199125102414322 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3828680 3775468 3685 Q3058I Dystrophin Homo sapiens 0.634108968039413 0.469227899297745 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3828681 3775469 3685 Q3058L Dystrophin Homo sapiens 0.100224251099692 0.26125681958601 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3828682 3775470 3685 Q3058M Dystrophin Homo sapiens 0.581483700376506 0.180928178138009 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3828683 3775471 3685 Q3058N Dystrophin Homo sapiens 0.113991456423867 0.329183034314125 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3828684 3775472 3685 Q3058P Dystrophin Homo sapiens 0.998976316459448 1.36976258471487 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3828685 3775473 3685 Q3058R Dystrophin Homo sapiens 0.23642629849513 0.339004686179409 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3828686 3775474 3685 Q3058S Dystrophin Homo sapiens 0.0666609851997983 0.288005516539738 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3828687 3775475 3685 Q3058T Dystrophin Homo sapiens 0.704238459730101 0.164858338072997 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3828688 3775476 3685 Q3058V Dystrophin Homo sapiens 1.1865843404458 0.806594683260139 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3828689 3775477 3685 Q3058W Dystrophin Homo sapiens 2.07812370132066 1.32982817570223 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3828690 3775478 3685 Q3058Y Dystrophin Homo sapiens 0.952543861936601 1.86887540559137 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3828691 3775479 3685 Q3058K Dystrophin Homo sapiens 0.115473940507048 0.152261935478583 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3828692 3775480 3685 Q3058H Dystrophin Homo sapiens 0.224834535191933 0.294882207728213 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3831086 3777868 3685 G3059A Dystrophin Homo sapiens -0.0851349569423858 0.0972884772139236 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 4.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3831087 3777869 3685 G3059C Dystrophin Homo sapiens 0.073757189381356 0.0891793561768556 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 4.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3831088 3777870 3685 G3059D Dystrophin Homo sapiens -0.20482000138243 0.0808191456470228 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 4.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3831089 3777871 3685 G3059E Dystrophin Homo sapiens -0.193464186921157 0.063465577565462 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 4.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3831090 3777872 3685 G3059F Dystrophin Homo sapiens 0.00766470439405678 0.0828119444946688 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 4.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3831091 3777873 3685 G3059H Dystrophin Homo sapiens -0.140921773670836 0.100942420949942 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 4.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3831092 3777874 3685 G3059I Dystrophin Homo sapiens 0.00783106869519325 0.0767220045095531 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 4.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3831093 3777875 3685 G3059K Dystrophin Homo sapiens -0.113343834917263 0.0899581291405671 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 4.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3831094 3777876 3685 G3059L Dystrophin Homo sapiens -0.0239656236490795 0.0827743376161056 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 4.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3831095 3777877 3685 G3059M Dystrophin Homo sapiens 0.0267210488087164 0.0910882709801422 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 4.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3831096 3777878 3685 G3059N Dystrophin Homo sapiens -0.120170046016798 0.106190155902387 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 4.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3831097 3777879 3685 G3059P Dystrophin Homo sapiens -0.167901085636316 0.0964776292512126 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 4.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3831098 3777880 3685 G3059Q Dystrophin Homo sapiens -0.132859970684144 0.106734060293576 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 4.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3831099 3777881 3685 G3059R Dystrophin Homo sapiens -0.0913938971985074 0.0687343305094633 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 4.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3831100 3777882 3685 G3059S Dystrophin Homo sapiens -0.109478552226638 0.0856756374045774 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 4.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3831101 3777883 3685 G3059T Dystrophin Homo sapiens -0.087619593446597 0.0819805083976014 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 4.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3831102 3777884 3685 G3059V Dystrophin Homo sapiens -0.0766325446996855 0.0567247325048722 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 4.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3831103 3777885 3685 G3059W Dystrophin Homo sapiens 0.100626926020475 0.0923781745367732 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 4.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3831104 3777886 3685 G3059Y Dystrophin Homo sapiens 0.0478233959017194 0.0732374323871478 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 4.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3832283 3779063 3685 P3060A Dystrophin Homo sapiens 0.250238026672603 0.0470429136367351 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3832284 3779064 3685 P3060C Dystrophin Homo sapiens 0.282198730918861 0.0951311004481369 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3832285 3779065 3685 P3060D Dystrophin Homo sapiens 0.117654616208222 0.0741478800634587 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3832286 3779066 3685 P3060E Dystrophin Homo sapiens 0.196974859927712 0.0955934557522677 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3832287 3779067 3685 P3060F Dystrophin Homo sapiens 0.145114006647712 0.123694588107084 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3832288 3779068 3685 P3060G Dystrophin Homo sapiens -0.0929215489207864 0.13483621102736 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3832289 3779069 3685 P3060H Dystrophin Homo sapiens 0.0426093777327088 0.11027377679312 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3832290 3779070 3685 P3060I Dystrophin Homo sapiens 0.644689295356406 0.0654038014279663 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3832291 3779071 3685 P3060K Dystrophin Homo sapiens 0.303171362412837 0.149907870911956 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3832292 3779072 3685 P3060L Dystrophin Homo sapiens 0.380318025325507 0.0931555802845226 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3832293 3779073 3685 P3060M Dystrophin Homo sapiens 0.284927390153498 0.0620174392975861 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3832294 3779074 3685 P3060N Dystrophin Homo sapiens -0.0703468396438444 0.103460945280243 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3832295 3779075 3685 P3060Q Dystrophin Homo sapiens 0.168877750451138 0.0594137593558166 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3832296 3779076 3685 P3060R Dystrophin Homo sapiens 0.294948272953839 0.0538236735264546 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3832297 3779077 3685 P3060S Dystrophin Homo sapiens 0.209073787209618 0.0788672282445654 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3832298 3779078 3685 P3060T Dystrophin Homo sapiens 0.369949171996796 0.136136967915641 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3832299 3779079 3685 P3060V Dystrophin Homo sapiens 0.66548061038291 0.0986586582905038 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3832300 3779080 3685 P3060W Dystrophin Homo sapiens 0.37698602437695 0.0893589734705797 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3832301 3779081 3685 P3060Y Dystrophin Homo sapiens 0.262761015958894 0.0839245544620711 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3833537 3780316 3685 W3061A Dystrophin Homo sapiens 0.49650018932734 0.0682775914809433 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3833538 3780317 3685 W3061C Dystrophin Homo sapiens 0.431261684871836 0.0702337995784325 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3833539 3780318 3685 W3061D Dystrophin Homo sapiens 0.593718842878342 0.0704098216005525 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3833540 3780319 3685 W3061E Dystrophin Homo sapiens 0.442973245550612 0.0876159655418547 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3833541 3780320 3685 W3061F Dystrophin Homo sapiens 0.197412537827687 0.0709026832624884 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3833542 3780321 3685 W3061G Dystrophin Homo sapiens 0.594304360147127 0.0638215623424586 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3833543 3780322 3685 W3061H Dystrophin Homo sapiens 0.536168424460408 0.0608877126865626 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3833544 3780323 3685 W3061I Dystrophin Homo sapiens 0.334047228617573 0.0903478475802079 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3833545 3780324 3685 W3061K Dystrophin Homo sapiens 0.497979156908561 0.0841740741883609 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3833546 3780325 3685 W3061L Dystrophin Homo sapiens 0.54160893123711 0.0673632998460096 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3833547 3780326 3685 W3061M Dystrophin Homo sapiens 0.491692157779999 0.062367533230499 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3833548 3780327 3685 W3061N Dystrophin Homo sapiens 0.416526821478979 0.0839218425357594 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3833549 3780328 3685 W3061P Dystrophin Homo sapiens 0.615939646896887 0.0644939782824035 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3833550 3780329 3685 W3061Q Dystrophin Homo sapiens 0.479923995485671 0.0570106269274383 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3833551 3780330 3685 W3061R Dystrophin Homo sapiens 0.661374236317893 0.0625463977114835 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3833552 3780331 3685 W3061S Dystrophin Homo sapiens 0.50157766932088 0.0558214472397538 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3833553 3780332 3685 W3061T Dystrophin Homo sapiens 0.473152878125647 0.0694139820038415 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3833554 3780333 3685 W3061V Dystrophin Homo sapiens 0.265803763522213 0.0574385317651653 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3833555 3780334 3685 W3061Y Dystrophin Homo sapiens 0.0796049284653816 0.13002585014912 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3834846 3781624 3685 E3062A Dystrophin Homo sapiens 0.135305514939364 0.0410704360698965 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3834847 3781625 3685 E3062C Dystrophin Homo sapiens 0.194936380313002 0.078556234437608 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3834848 3781626 3685 E3062D Dystrophin Homo sapiens 0.194921785423266 0.0634066207375577 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3834849 3781627 3685 E3062F Dystrophin Homo sapiens 0.441735999500934 0.0814595315991932 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3834850 3781628 3685 E3062G Dystrophin Homo sapiens 0.267839688749899 0.0553486763381371 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3834851 3781629 3685 E3062H Dystrophin Homo sapiens 0.276849360620161 0.146261218994403 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3834852 3781630 3685 E3062I Dystrophin Homo sapiens 0.276835947275084 0.0659139631542658 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3834853 3781631 3685 E3062K Dystrophin Homo sapiens 0.275781570580143 0.117369150517575 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3834854 3781632 3685 E3062L Dystrophin Homo sapiens 0.343814619451011 0.10652622096172 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3834855 3781633 3685 E3062M Dystrophin Homo sapiens 0.236002067698651 0.0740270586825092 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3834856 3781634 3685 E3062N Dystrophin Homo sapiens 0.314120117860002 0.0789136978333489 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3834857 3781635 3685 E3062P Dystrophin Homo sapiens 1.06963049274821 0.0972634509727733 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3834858 3781636 3685 E3062Q Dystrophin Homo sapiens -0.00913243886141613 0.0570530331278768 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3834859 3781637 3685 E3062R Dystrophin Homo sapiens 0.33827765361894 0.0583250987360045 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3834860 3781638 3685 E3062S Dystrophin Homo sapiens 0.0738249582818524 0.0618596400699441 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3834861 3781639 3685 E3062T Dystrophin Homo sapiens 0.106266956305198 0.0749712760304444 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3834862 3781640 3685 E3062V Dystrophin Homo sapiens 0.139204719214498 0.0982927451625328 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3834863 3781641 3685 E3062W Dystrophin Homo sapiens 0.72752268769983 0.0349523989527985 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3834864 3781642 3685 E3062Y Dystrophin Homo sapiens 0.441528452742041 0.142787770270998 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3836157 3782934 3685 R3063A Dystrophin Homo sapiens -0.0806499765839229 0.069905163621801 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3836158 3782935 3685 R3063C Dystrophin Homo sapiens 0.047648413638899 0.0989253554255688 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3836159 3782936 3685 R3063D Dystrophin Homo sapiens 0.322671260380267 0.0554615543631387 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3836160 3782937 3685 R3063E Dystrophin Homo sapiens -0.251414361281928 0.118560152034595 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3836161 3782938 3685 R3063F Dystrophin Homo sapiens 0.229034161262531 0.0931107423526486 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3836162 3782939 3685 R3063G Dystrophin Homo sapiens 0.260909456709179 0.0581561322234174 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3836163 3782940 3685 R3063H Dystrophin Homo sapiens 0.272482844179734 0.0605398771918686 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3836164 3782941 3685 R3063I Dystrophin Homo sapiens -0.117877568058902 0.124394529536453 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3836165 3782942 3685 R3063K Dystrophin Homo sapiens -0.0234776108213665 0.0822305457529797 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3836166 3782943 3685 R3063L Dystrophin Homo sapiens -0.0266470165962486 0.107398515998363 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3836167 3782944 3685 R3063M Dystrophin Homo sapiens -0.0473389895984168 0.0832172930822223 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3836168 3782945 3685 R3063N Dystrophin Homo sapiens 0.38821815924448 0.18381293630126 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3836169 3782946 3685 R3063P Dystrophin Homo sapiens 0.257529473794675 0.0689874848921792 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3836170 3782947 3685 R3063Q Dystrophin Homo sapiens -0.100772757888646 0.0953864266224634 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3836171 3782948 3685 R3063S Dystrophin Homo sapiens -0.00873109177177319 0.0674341700199148 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3836172 3782949 3685 R3063T Dystrophin Homo sapiens 0.069093940940641 0.0868311475706135 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3836173 3782950 3685 R3063V Dystrophin Homo sapiens -0.0721170748626268 0.101322259425675 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3836174 3782951 3685 R3063W Dystrophin Homo sapiens 0.301468610273271 0.0588022368517356 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3836175 3782952 3685 R3063Y Dystrophin Homo sapiens 0.169176658744158 0.0942402720395624 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3837468 3784244 3685 A3064C Dystrophin Homo sapiens 0.019350608111891 0.0731706075970976 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3837469 3784245 3685 A3064D Dystrophin Homo sapiens 0.136402945996385 0.0798002051643147 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3837470 3784246 3685 A3064E Dystrophin Homo sapiens 0.188035022973178 0.04800191267099 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3837471 3784247 3685 A3064F Dystrophin Homo sapiens 0.169317003743991 0.0543544098837431 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3837472 3784248 3685 A3064G Dystrophin Homo sapiens 0.105001263161263 0.0841626525899942 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3837473 3784249 3685 A3064H Dystrophin Homo sapiens 0.128321533869483 0.0497845867418262 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3837474 3784250 3685 A3064I Dystrophin Homo sapiens 0.174389239929808 0.145086212216219 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3837475 3784251 3685 A3064K Dystrophin Homo sapiens -0.0793149053881941 0.0587729638014979 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3837476 3784252 3685 A3064L Dystrophin Homo sapiens 0.113003613071293 0.0631726951502005 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3837477 3784253 3685 A3064M Dystrophin Homo sapiens 6.23834649536199E-4 0.0748660341597794 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3837478 3784254 3685 A3064N Dystrophin Homo sapiens 0.110454828819644 0.0886501479506591 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3837479 3784255 3685 A3064P Dystrophin Homo sapiens 1.10531657354471 0.0921287392065305 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3837480 3784256 3685 A3064Q Dystrophin Homo sapiens 0.0036374883072934 0.120324085681865 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3837481 3784257 3685 A3064R Dystrophin Homo sapiens -0.0846428773504859 0.0798235029744216 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3837482 3784258 3685 A3064S Dystrophin Homo sapiens 0.031778179227393 0.0888282067307144 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3837483 3784259 3685 A3064T Dystrophin Homo sapiens 0.119933185697565 0.0683429320258461 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3837484 3784260 3685 A3064V Dystrophin Homo sapiens 0.0652081331313749 0.0904625811929639 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3837485 3784261 3685 A3064W Dystrophin Homo sapiens 0.373604421058342 0.0638820934379604 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3837486 3784262 3685 A3064Y Dystrophin Homo sapiens 0.14299287517093 0.0861036941551891 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3838779 3785553 3685 I3065A Dystrophin Homo sapiens -0.0549978475969746 0.0755966676182565 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3838780 3785554 3685 I3065C Dystrophin Homo sapiens -0.0619864141854118 0.0565382476234799 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3838781 3785555 3685 I3065D Dystrophin Homo sapiens 0.181481714931367 0.0582046622010295 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3838782 3785556 3685 I3065E Dystrophin Homo sapiens -0.0689731195596916 0.100910749926687 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3838783 3785557 3685 I3065F Dystrophin Homo sapiens 0.0241019491465114 0.0761886777562607 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3838784 3785558 3685 I3065G Dystrophin Homo sapiens 0.328569497557721 0.0584375108948264 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3838785 3785559 3685 I3065H Dystrophin Homo sapiens -0.00562984041853039 0.114466504893473 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3838786 3785560 3685 I3065K Dystrophin Homo sapiens -0.125105290539052 0.0693520049227336 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3838787 3785561 3685 I3065L Dystrophin Homo sapiens -0.0853797943759856 0.118776436597559 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3838788 3785562 3685 I3065M Dystrophin Homo sapiens 0.0819178640250815 0.0640422242470622 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3838789 3785563 3685 I3065N Dystrophin Homo sapiens -0.0356745804284842 0.0548974680639 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3838790 3785564 3685 I3065P Dystrophin Homo sapiens 0.383696106515751 0.0469899748096254 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3838791 3785565 3685 I3065Q Dystrophin Homo sapiens -0.100755241770402 0.0984576269064428 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3838792 3785566 3685 I3065R Dystrophin Homo sapiens -0.115999643484091 0.0917732292979585 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3838793 3785567 3685 I3065S Dystrophin Homo sapiens -0.070532871037144 0.105901105067661 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3838794 3785568 3685 I3065T Dystrophin Homo sapiens -0.0937720877817824 0.0599557282643264 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3838795 3785569 3685 I3065V Dystrophin Homo sapiens -0.121235613627578 0.0694276091522377 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3838796 3785570 3685 I3065W Dystrophin Homo sapiens -0.0785794602297548 0.073427745473234 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3838797 3785571 3685 I3065Y Dystrophin Homo sapiens -0.01542388960014 0.137640331580861 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3840090 3786863 3685 S3066A Dystrophin Homo sapiens 0.160977076397465 0.0616533041130062 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3840091 3786864 3685 S3066C Dystrophin Homo sapiens 0.212613312411456 0.0772782239719266 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3840092 3786865 3685 S3066D Dystrophin Homo sapiens -0.146346706563656 0.128946447213028 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3840093 3786866 3685 S3066E Dystrophin Homo sapiens 0.334352978616808 0.0665006169564842 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3840094 3786867 3685 S3066F Dystrophin Homo sapiens 0.517847786831933 0.0647672211748773 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3840095 3786868 3685 S3066G Dystrophin Homo sapiens 0.257675985332345 0.0854754724865995 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3840096 3786869 3685 S3066H Dystrophin Homo sapiens 0.244987242209658 0.117303973138363 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3840097 3786870 3685 S3066I Dystrophin Homo sapiens 0.579655862042413 0.108131799492718 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3840098 3786871 3685 S3066K Dystrophin Homo sapiens 0.407207551149738 0.12745035286066 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3840099 3786872 3685 S3066L Dystrophin Homo sapiens 0.333924055400113 0.119989562256991 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3840100 3786873 3685 S3066M Dystrophin Homo sapiens 0.286326980439272 0.0700455660109455 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3840101 3786874 3685 S3066N Dystrophin Homo sapiens 0.0324058315039852 0.0920319650725856 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3840102 3786875 3685 S3066P Dystrophin Homo sapiens 0.810717092574094 0.146486196350212 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3840103 3786876 3685 S3066Q Dystrophin Homo sapiens 0.386762631258724 0.171326901230768 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3840104 3786877 3685 S3066R Dystrophin Homo sapiens 0.674283905786132 0.0659098209962768 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3840105 3786878 3685 S3066T Dystrophin Homo sapiens -0.028001407735067 0.152547779263521 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3840106 3786879 3685 S3066V Dystrophin Homo sapiens 0.537370820569059 0.0924552281277252 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3840107 3786880 3685 S3066W Dystrophin Homo sapiens 0.682760644751321 0.146408416953256 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3840108 3786881 3685 S3066Y Dystrophin Homo sapiens 0.731952321130641 0.0586749338543731 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3841401 3788171 3685 P3067A Dystrophin Homo sapiens -0.123401761955854 0.114301122399684 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 4.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3841402 3788172 3685 P3067C Dystrophin Homo sapiens 0.0525002771172337 0.0996746977997548 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 4.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3841403 3788173 3685 P3067D Dystrophin Homo sapiens -0.197849698098573 0.124798274599112 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 4.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3841404 3788174 3685 P3067E Dystrophin Homo sapiens -0.173284326881896 0.0811246987221473 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 4.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3841405 3788175 3685 P3067F Dystrophin Homo sapiens 0.244098124227637 0.106412560866682 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 4.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3841406 3788176 3685 P3067G Dystrophin Homo sapiens -0.0931748113304425 0.0964102857067933 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 4.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3841407 3788177 3685 P3067H Dystrophin Homo sapiens -0.0794724379243274 0.0951571169362393 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 4.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3841408 3788178 3685 P3067I Dystrophin Homo sapiens -0.0381683148265668 0.0731131170098507 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 4.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3841409 3788179 3685 P3067K Dystrophin Homo sapiens -0.223114735050865 0.106017398319367 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 4.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3841410 3788180 3685 P3067L Dystrophin Homo sapiens 0.0652752876286488 0.0817770081478442 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 4.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3841411 3788181 3685 P3067M Dystrophin Homo sapiens -0.059012079183108 0.0470585910464342 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 4.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3841412 3788182 3685 P3067N Dystrophin Homo sapiens -0.161294731865735 0.103657025429544 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 4.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3841413 3788183 3685 P3067Q Dystrophin Homo sapiens -0.0450268136031403 0.0965857957262278 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 4.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3841414 3788184 3685 P3067R Dystrophin Homo sapiens -0.0670837362522525 0.0693585281745299 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 4.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3841415 3788185 3685 P3067S Dystrophin Homo sapiens -0.181120758664559 0.0894702074605849 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 4.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3841416 3788186 3685 P3067T Dystrophin Homo sapiens -0.147102591319409 0.0866976060174535 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 4.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3841417 3788187 3685 P3067V Dystrophin Homo sapiens 0.017493352691641 0.0714744878615495 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 4.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3841418 3788188 3685 P3067W Dystrophin Homo sapiens 0.293354538001444 0.0563915594167515 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 4.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3841419 3788189 3685 P3067Y Dystrophin Homo sapiens 0.101127619635577 0.0454425260252709 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 4.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3842712 3789480 3685 N3068A Dystrophin Homo sapiens -0.0883061946741292 0.0837643482591674 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3842713 3789481 3685 N3068C Dystrophin Homo sapiens -0.0155767961076147 0.084497029728386 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3842714 3789482 3685 N3068D Dystrophin Homo sapiens -0.190208828836123 0.0485358887112043 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3842715 3789483 3685 N3068E Dystrophin Homo sapiens -0.160239207384554 0.115830277496881 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3842716 3789484 3685 N3068F Dystrophin Homo sapiens 0.167834649068082 0.0801609071177009 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3842717 3789485 3685 N3068G Dystrophin Homo sapiens -0.117660940285347 0.0950031785464294 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3842718 3789486 3685 N3068H Dystrophin Homo sapiens 0.0182910978867282 0.069904916060063 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3842719 3789487 3685 N3068I Dystrophin Homo sapiens 0.136478389310759 0.0984567773195693 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3842720 3789488 3685 N3068K Dystrophin Homo sapiens -0.144500053537476 0.0792329782068454 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3842721 3789489 3685 N3068L Dystrophin Homo sapiens 0.0907682130377322 0.096985517910645 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3842722 3789490 3685 N3068M Dystrophin Homo sapiens 0.0667438598674351 0.0871503514250274 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3842723 3789491 3685 N3068P Dystrophin Homo sapiens 0.413446219475359 0.04440973108748 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3842724 3789492 3685 N3068Q Dystrophin Homo sapiens -0.0627398503305198 0.0730816204050935 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3842725 3789493 3685 N3068R Dystrophin Homo sapiens -0.0132594224411209 0.0978500597637666 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3842726 3789494 3685 N3068S Dystrophin Homo sapiens -0.0496322575033133 0.0614081504755502 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3842727 3789495 3685 N3068T Dystrophin Homo sapiens -0.0691952049442886 0.0799230047886069 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3842728 3789496 3685 N3068V Dystrophin Homo sapiens 0.084043991747849 0.0744221334579358 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3842729 3789497 3685 N3068W Dystrophin Homo sapiens 0.227674878528826 0.0829090112015767 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3842730 3789498 3685 N3068Y Dystrophin Homo sapiens 0.139337119733102 0.103349126144312 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3844194 3790958 3685 K3069A Dystrophin Homo sapiens 0.244967223467299 0.0702026911954918 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3844195 3790959 3685 K3069C Dystrophin Homo sapiens 0.309450732138746 0.0654588006439045 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3844196 3790960 3685 K3069D Dystrophin Homo sapiens 0.11894659590761 0.089766870818754 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3844197 3790961 3685 K3069E Dystrophin Homo sapiens 0.156358440832498 0.0864873585850552 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3844198 3790962 3685 K3069F Dystrophin Homo sapiens 0.480028128954918 0.19109406459998 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3844199 3790963 3685 K3069G Dystrophin Homo sapiens -0.115923552008075 0.102370233273847 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3844200 3790964 3685 K3069H Dystrophin Homo sapiens 0.165451079643409 0.0863656099728689 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3844201 3790965 3685 K3069I Dystrophin Homo sapiens 0.993287685304434 0.146329287219546 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3844202 3790966 3685 K3069L Dystrophin Homo sapiens 0.48352860691899 0.120796478489191 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3844203 3790967 3685 K3069M Dystrophin Homo sapiens 0.222134255534716 0.157058016545663 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3844204 3790968 3685 K3069N Dystrophin Homo sapiens 1.38915555851709E-4 0.117780159266684 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3844205 3790969 3685 K3069P Dystrophin Homo sapiens 0.756779207565094 0.0967338826567759 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3844206 3790970 3685 K3069Q Dystrophin Homo sapiens 0.12831351061861 0.0989008580663132 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3844207 3790971 3685 K3069R Dystrophin Homo sapiens 0.31275847203698 0.118085058553764 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3844208 3790972 3685 K3069S Dystrophin Homo sapiens 0.269181000751987 0.104896432018026 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3844209 3790973 3685 K3069T Dystrophin Homo sapiens 0.453976070731917 0.091582449220412 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3844210 3790974 3685 K3069V Dystrophin Homo sapiens 0.866498828660511 0.0765824359533534 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3844211 3790975 3685 K3069W Dystrophin Homo sapiens 0.708512916962412 0.120745176945394 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3844212 3790976 3685 K3069Y Dystrophin Homo sapiens 0.377288027191695 0.0545272057263046 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3845505 3792268 3685 V3070A Dystrophin Homo sapiens -0.0686585721165133 0.0809787948360161 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3845506 3792269 3685 V3070C Dystrophin Homo sapiens 0.0828462092897691 0.0863191291312791 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3845507 3792270 3685 V3070D Dystrophin Homo sapiens -0.0803155600607091 0.101010657967179 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3845508 3792271 3685 V3070E Dystrophin Homo sapiens -0.262665142049451 0.113637623183429 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3845509 3792272 3685 V3070F Dystrophin Homo sapiens 0.345619389532244 0.0982088059794226 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3845510 3792273 3685 V3070G Dystrophin Homo sapiens 0.102800862415973 0.0736721170406541 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3845511 3792274 3685 V3070H Dystrophin Homo sapiens 0.0541983964764565 0.0985013046739901 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3845512 3792275 3685 V3070I Dystrophin Homo sapiens 0.1830227754976 0.113611511046474 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3845513 3792276 3685 V3070K Dystrophin Homo sapiens -0.0418597562889273 0.0787270407840207 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3845514 3792277 3685 V3070L Dystrophin Homo sapiens 0.14552960654178 0.0589292022649099 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3845515 3792278 3685 V3070M Dystrophin Homo sapiens 0.108595747068936 0.0774012756590793 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3845516 3792279 3685 V3070N Dystrophin Homo sapiens 0.00236858653817738 0.104825573096928 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3845517 3792280 3685 V3070P Dystrophin Homo sapiens 0.580766041403661 0.101626006425393 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3845518 3792281 3685 V3070Q Dystrophin Homo sapiens -0.102953623762247 0.0970437849415248 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3845519 3792282 3685 V3070R Dystrophin Homo sapiens -0.0549303487638287 0.0804850442023846 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3845520 3792283 3685 V3070S Dystrophin Homo sapiens -0.0312736270250204 0.06513588223814 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3845521 3792284 3685 V3070T Dystrophin Homo sapiens -0.0221614724721914 0.0987424815697094 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3845522 3792285 3685 V3070W Dystrophin Homo sapiens 0.401179479093509 0.0789844037162825 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3845523 3792286 3685 V3070Y Dystrophin Homo sapiens 0.325095677491709 0.113239723953628 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3846721 3793482 3685 P3071A Dystrophin Homo sapiens -0.0326745935290013 0.0706691200154932 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3846722 3793483 3685 P3071C Dystrophin Homo sapiens -0.00616247613698957 0.0986286301769652 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3846723 3793484 3685 P3071D Dystrophin Homo sapiens 0.292410472566393 0.0658723243952151 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3846724 3793485 3685 P3071E Dystrophin Homo sapiens 0.0981491593544937 0.0825217008624783 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3846725 3793486 3685 P3071F Dystrophin Homo sapiens 0.201704999550034 0.0622783491143851 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3846726 3793487 3685 P3071G Dystrophin Homo sapiens 0.241082709730754 0.0833979523858073 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3846727 3793488 3685 P3071H Dystrophin Homo sapiens 0.0835180130770527 0.0765930698552811 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3846728 3793489 3685 P3071I Dystrophin Homo sapiens -0.100441603553971 0.104775790681977 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3846729 3793490 3685 P3071K Dystrophin Homo sapiens -0.116169864684577 0.0956443184366201 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3846730 3793491 3685 P3071L Dystrophin Homo sapiens 0.00478946610491247 0.0757361394003222 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3846731 3793492 3685 P3071M Dystrophin Homo sapiens -0.0142414976051991 0.0692173032052469 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3846732 3793493 3685 P3071N Dystrophin Homo sapiens 0.104737609910294 0.0628793536204431 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3846733 3793494 3685 P3071Q Dystrophin Homo sapiens -0.0561706386976036 0.0744498671242754 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3846734 3793495 3685 P3071R Dystrophin Homo sapiens 0.0665174680338775 0.0878926990548343 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3846735 3793496 3685 P3071S Dystrophin Homo sapiens 0.0252573119007854 0.0563055092071845 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3846736 3793497 3685 P3071T Dystrophin Homo sapiens -0.0975591634688123 0.0890467193493199 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3846737 3793498 3685 P3071V Dystrophin Homo sapiens -0.0731272505345291 0.10119303219844 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3846738 3793499 3685 P3071W Dystrophin Homo sapiens 0.246504413068175 0.085292704407119 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3846739 3793500 3685 P3071Y Dystrophin Homo sapiens 0.176485423935084 0.158714215825678 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3848032 3794792 3685 Y3072A Dystrophin Homo sapiens 0.477530050973615 0.122519947045104 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3848033 3794793 3685 Y3072C Dystrophin Homo sapiens 0.337744765725092 0.131708943636127 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3848034 3794794 3685 Y3072D Dystrophin Homo sapiens 0.603726559895345 0.0587631963656532 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3848035 3794795 3685 Y3072E Dystrophin Homo sapiens 0.390020318674657 0.103165682896455 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3848036 3794796 3685 Y3072F Dystrophin Homo sapiens 0.065694771991442 0.0856505098881706 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3848037 3794797 3685 Y3072G Dystrophin Homo sapiens 0.627587010315877 0.150398605793507 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3848038 3794798 3685 Y3072H Dystrophin Homo sapiens 0.350048381553097 0.145613912566375 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3848039 3794799 3685 Y3072I Dystrophin Homo sapiens 0.325907713750763 0.101899967246907 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3848040 3794800 3685 Y3072K Dystrophin Homo sapiens 0.449246347463427 0.0839029603268339 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3848041 3794801 3685 Y3072L Dystrophin Homo sapiens 0.359797058969703 0.0494493375109482 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3848042 3794802 3685 Y3072M Dystrophin Homo sapiens 0.323828217657189 0.111219557155847 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3848043 3794803 3685 Y3072N Dystrophin Homo sapiens 0.660553963004648 0.142035092565033 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3848044 3794804 3685 Y3072P Dystrophin Homo sapiens 0.796469239383912 0.147680850528148 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3848045 3794805 3685 Y3072Q Dystrophin Homo sapiens 0.365343173333274 0.0683433900150614 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3848046 3794806 3685 Y3072R Dystrophin Homo sapiens 0.560986893795769 0.100314480601509 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3848047 3794807 3685 Y3072S Dystrophin Homo sapiens 0.488590996899318 0.124882079873828 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3848048 3794808 3685 Y3072T Dystrophin Homo sapiens 0.451346379928449 0.0872975268782674 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3848049 3794809 3685 Y3072V Dystrophin Homo sapiens 0.31705789924641 0.0629177166875878 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3848050 3794810 3685 Y3072W Dystrophin Homo sapiens 0.418485755006148 0.096210435867391 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 7.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3849343 3796100 3685 Y3073A Dystrophin Homo sapiens 0.64078823999464 0.0240387432589586 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3849344 3796101 3685 Y3073C Dystrophin Homo sapiens 0.914327531385669 0.10025104853255 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3849345 3796102 3685 Y3073D Dystrophin Homo sapiens 0.541326688350179 0.114173920677578 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3849346 3796103 3685 Y3073E Dystrophin Homo sapiens 0.627813979418397 0.101890193059378 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3849347 3796104 3685 Y3073F Dystrophin Homo sapiens 0.0498942847237751 0.0805007306143287 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3849348 3796105 3685 Y3073G Dystrophin Homo sapiens 0.64212480331248 0.0701089361894699 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3849349 3796106 3685 Y3073H Dystrophin Homo sapiens 0.734065620654258 0.218673916330619 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3849350 3796107 3685 Y3073I Dystrophin Homo sapiens 0.841007283970758 0.246857087269566 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3849351 3796108 3685 Y3073K Dystrophin Homo sapiens 0.672237290392486 0.0908172358882591 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3849352 3796109 3685 Y3073L Dystrophin Homo sapiens 0.843511370950611 0.0539496014308906 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3849353 3796110 3685 Y3073M Dystrophin Homo sapiens 0.955222311149649 0.11663873536354 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3849354 3796111 3685 Y3073N Dystrophin Homo sapiens 0.856673553391607 0.105344282454872 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3849355 3796112 3685 Y3073P Dystrophin Homo sapiens 0.711373492844983 0.0900840199107424 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3849356 3796113 3685 Y3073Q Dystrophin Homo sapiens 0.624173696589194 0.0883498668152733 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3849357 3796114 3685 Y3073R Dystrophin Homo sapiens 0.806656855014795 0.0793560276434368 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3849358 3796115 3685 Y3073S Dystrophin Homo sapiens 0.613730417199795 0.0928232173984535 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3849359 3796116 3685 Y3073T Dystrophin Homo sapiens 0.751459330871635 0.0718225157792307 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3849360 3796117 3685 Y3073V Dystrophin Homo sapiens 0.791873480774098 0.0764733692538363 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3849361 3796118 3685 Y3073W Dystrophin Homo sapiens 0.0523744651167023 0.0719373180341049 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3850654 3797409 3685 I3074A Dystrophin Homo sapiens 0.225053818627768 0.0770469630490948 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3850655 3797410 3685 I3074C Dystrophin Homo sapiens 0.136302778016068 0.0864651612994018 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3850656 3797411 3685 I3074D Dystrophin Homo sapiens 0.60457738457762 0.118341525762646 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3850657 3797412 3685 I3074E Dystrophin Homo sapiens 0.204108497694616 0.0667115755662389 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3850658 3797413 3685 I3074F Dystrophin Homo sapiens 0.194808728478645 0.0740533564907684 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3850659 3797414 3685 I3074G Dystrophin Homo sapiens 0.590519028645069 0.0678870605886896 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3850660 3797415 3685 I3074H Dystrophin Homo sapiens 0.314877938098434 0.053094723487796 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3850661 3797416 3685 I3074K Dystrophin Homo sapiens 0.027485100851262 0.160237463199582 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3850662 3797417 3685 I3074L Dystrophin Homo sapiens 0.00430515241220545 0.0716414412470943 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3850663 3797418 3685 I3074M Dystrophin Homo sapiens -0.0110581422890211 0.0735138519468324 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3850664 3797419 3685 I3074N Dystrophin Homo sapiens 0.444490720234898 0.0940096750323007 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3850665 3797420 3685 I3074P Dystrophin Homo sapiens 0.734268722554673 0.219955475931399 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3850666 3797421 3685 I3074Q Dystrophin Homo sapiens 0.147929031170492 0.0667432916007184 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3850667 3797422 3685 I3074R Dystrophin Homo sapiens 0.184323329835369 0.051940532150655 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3850668 3797423 3685 I3074S Dystrophin Homo sapiens 0.354489650385594 0.0437086452477136 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3850669 3797424 3685 I3074T Dystrophin Homo sapiens 0.169983068600076 0.0679472867331415 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3850670 3797425 3685 I3074V Dystrophin Homo sapiens -0.0936486444969714 0.100240020782403 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3850671 3797426 3685 I3074W Dystrophin Homo sapiens 0.30949687989727 0.0533975702630119 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3850672 3797427 3685 I3074Y Dystrophin Homo sapiens 0.0906385975886807 0.136701847537722 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3851965 3798716 3685 N3075A Dystrophin Homo sapiens 0.879546570061715 0.119704427398849 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 5.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3851966 3798717 3685 N3075C Dystrophin Homo sapiens 0.224275878371721 0.0932724181720515 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 5.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3851967 3798718 3685 N3075D Dystrophin Homo sapiens 0.273067742544174 0.0656073433131066 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 5.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3851968 3798719 3685 N3075E Dystrophin Homo sapiens 0.497676906532078 0.0910729964209077 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 5.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3851969 3798720 3685 N3075F Dystrophin Homo sapiens 1.09198410238639 0.209626930154756 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 5.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3851970 3798721 3685 N3075G Dystrophin Homo sapiens 0.912802663607662 0.153737921066142 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 5.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3851971 3798722 3685 N3075H Dystrophin Homo sapiens 0.230078860544078 0.176159171322821 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 5.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3851972 3798723 3685 N3075I Dystrophin Homo sapiens 1.66202148198077 0.776185268381016 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 5.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3851973 3798724 3685 N3075K Dystrophin Homo sapiens 0.847987129634333 0.0980918938233722 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 5.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3851974 3798725 3685 N3075L Dystrophin Homo sapiens 1.2560524146894 0.329312992973768 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 5.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3851975 3798726 3685 N3075M Dystrophin Homo sapiens 0.900614749133752 0.125662439483224 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 5.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3851976 3798727 3685 N3075P Dystrophin Homo sapiens 1.07182333835937 0.207176946667462 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 5.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3851977 3798728 3685 N3075Q Dystrophin Homo sapiens 0.487953300367847 0.0954278437012305 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 5.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3851978 3798729 3685 N3075R Dystrophin Homo sapiens 0.78826835171169 0.0890755265333779 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 5.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3851979 3798730 3685 N3075S Dystrophin Homo sapiens 0.352674955329229 0.0605605823554103 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 5.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3851980 3798731 3685 N3075T Dystrophin Homo sapiens 0.927458656081353 0.139222689946115 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 5.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3851981 3798732 3685 N3075V Dystrophin Homo sapiens 1.43615391666739 0.143639067571137 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 5.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3851982 3798733 3685 N3075W Dystrophin Homo sapiens 1.00587518692909 0.170015037822696 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 5.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3851983 3798734 3685 N3075Y Dystrophin Homo sapiens 0.776290144535477 0.204409937869048 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 5.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3853276 3800026 3685 H3076A Dystrophin Homo sapiens 0.0985085177228109 0.0500016983860507 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3853277 3800027 3685 H3076C Dystrophin Homo sapiens 0.130862327503398 0.0634017786550185 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3853278 3800028 3685 H3076D Dystrophin Homo sapiens 0.282841817544537 0.0697914123790326 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3853279 3800029 3685 H3076E Dystrophin Homo sapiens 0.144639588335257 0.12833105374359 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3853280 3800030 3685 H3076F Dystrophin Homo sapiens 0.330813959791252 0.0887979873194692 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3853281 3800031 3685 H3076G Dystrophin Homo sapiens 0.198240676852516 0.0689905535324498 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3853282 3800032 3685 H3076I Dystrophin Homo sapiens 0.0529326436926478 0.0711045856137548 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3853283 3800033 3685 H3076K Dystrophin Homo sapiens -0.0754788844950006 0.0710230320255744 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3853284 3800034 3685 H3076L Dystrophin Homo sapiens 0.0922367616456254 0.0700112697079877 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3853285 3800035 3685 H3076M Dystrophin Homo sapiens 0.0331002241745806 0.0795426329298562 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3853286 3800036 3685 H3076N Dystrophin Homo sapiens 0.020378234635761 0.140367764259614 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3853287 3800037 3685 H3076P Dystrophin Homo sapiens 0.233436697935837 0.0491128077107163 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3853288 3800038 3685 H3076Q Dystrophin Homo sapiens 0.0991280747305706 0.0833244423035505 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3853289 3800039 3685 H3076R Dystrophin Homo sapiens 0.0354710981832171 0.106418941207839 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3853290 3800040 3685 H3076S Dystrophin Homo sapiens 0.0488266038359777 0.0712682644326743 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3853291 3800041 3685 H3076T Dystrophin Homo sapiens 0.0110468214032705 0.0794874649218239 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3853292 3800042 3685 H3076V Dystrophin Homo sapiens 0.0959825372830734 0.0633975284700894 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3853293 3800043 3685 H3076W Dystrophin Homo sapiens 0.272262604255365 0.0749239478525422 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3853294 3800044 3685 H3076Y Dystrophin Homo sapiens 0.245250501612407 0.0771506351532847 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3854587 3801335 3685 E3077A Dystrophin Homo sapiens -0.0349454976067115 0.101075215316765 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3854588 3801336 3685 E3077C Dystrophin Homo sapiens 0.104648836521609 0.0785193814970651 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3854589 3801337 3685 E3077D Dystrophin Homo sapiens 0.0331972976331723 0.0812631982617511 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3854590 3801338 3685 E3077F Dystrophin Homo sapiens 0.145969940104035 0.0578310679074968 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3854591 3801339 3685 E3077G Dystrophin Homo sapiens 0.0123873625881285 0.0910380159473285 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3854592 3801340 3685 E3077H Dystrophin Homo sapiens -0.0233372208103089 0.104335805956717 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3854593 3801341 3685 E3077I Dystrophin Homo sapiens 0.0281340344350771 0.0816822685212735 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3854594 3801342 3685 E3077K Dystrophin Homo sapiens -0.123927155480724 0.0670060243721335 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3854595 3801343 3685 E3077L Dystrophin Homo sapiens 0.0233635163680068 0.0780870531811923 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3854596 3801344 3685 E3077M Dystrophin Homo sapiens 0.0678052166781073 0.0394263144268536 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3854597 3801345 3685 E3077N Dystrophin Homo sapiens -0.0198898302103896 0.148790591029951 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3854598 3801346 3685 E3077P Dystrophin Homo sapiens 0.245267774670035 0.0681469835343785 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3854599 3801347 3685 E3077Q Dystrophin Homo sapiens 0.0176824122151085 0.065791883709575 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3854600 3801348 3685 E3077R Dystrophin Homo sapiens -0.0422045107652638 0.0831083276579617 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3854601 3801349 3685 E3077S Dystrophin Homo sapiens -0.00972883309274421 0.0951267748694057 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3854602 3801350 3685 E3077T Dystrophin Homo sapiens -0.0633910097194156 0.0943997918212835 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3854603 3801351 3685 E3077V Dystrophin Homo sapiens -0.0202073731505976 0.0750428832631604 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3854604 3801352 3685 E3077W Dystrophin Homo sapiens 0.19391373653175 0.0833442922538155 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3854605 3801353 3685 E3077Y Dystrophin Homo sapiens 0.159399781795033 0.0813283137505284 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 6.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3855898 3802644 3685 T3078A Dystrophin Homo sapiens 0.00658546428607188 0.102059667073528 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3855899 3802645 3685 T3078C Dystrophin Homo sapiens 0.0300462226797083 0.0668404201980608 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3855900 3802646 3685 T3078D Dystrophin Homo sapiens 0.152615082297838 0.06397378130347 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3855901 3802647 3685 T3078E Dystrophin Homo sapiens 0.15441064758354 0.0584678405835731 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3855902 3802648 3685 T3078F Dystrophin Homo sapiens 0.150083054600009 0.0948721171117718 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3855903 3802649 3685 T3078G Dystrophin Homo sapiens 0.0801742304403277 0.0964808408021228 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3855904 3802650 3685 T3078H Dystrophin Homo sapiens 0.0205372412895161 0.0845601354659631 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3855905 3802651 3685 T3078I Dystrophin Homo sapiens 0.293412309908847 0.124030399978276 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3855906 3802652 3685 T3078K Dystrophin Homo sapiens 0.00695928341067391 0.132191812806093 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3855907 3802653 3685 T3078L Dystrophin Homo sapiens 3.25770924637713E-4 0.111453999247012 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3855908 3802654 3685 T3078M Dystrophin Homo sapiens 0.0963281334693191 0.116557737663989 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3855909 3802655 3685 T3078N Dystrophin Homo sapiens -0.087753850678236 0.154041499273765 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3855910 3802656 3685 T3078P Dystrophin Homo sapiens 0.887752116395733 0.116044193344124 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3855911 3802657 3685 T3078Q Dystrophin Homo sapiens 0.0722971197629892 0.0837236356060729 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3855912 3802658 3685 T3078R Dystrophin Homo sapiens 0.0856643620926922 0.0913354906328298 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3855913 3802659 3685 T3078S Dystrophin Homo sapiens -0.0573370652110048 0.085534966073363 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3855914 3802660 3685 T3078V Dystrophin Homo sapiens 0.287077430089595 0.059713383327316 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3855915 3802661 3685 T3078W Dystrophin Homo sapiens 0.30247689547372 0.156760514853426 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3855916 3802662 3685 T3078Y Dystrophin Homo sapiens 0.12778479751589 0.0744607868474824 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3857209 3803950 3685 Q3079A Dystrophin Homo sapiens 0.0271683028468292 0.0664662418838825 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3857210 3803951 3685 Q3079C Dystrophin Homo sapiens 0.0303464025398376 0.0915702680576218 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3857211 3803952 3685 Q3079D Dystrophin Homo sapiens 0.180496396708521 0.133881459927473 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3857212 3803953 3685 Q3079E Dystrophin Homo sapiens 0.0364207236298469 0.10079795179661 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3857213 3803954 3685 Q3079F Dystrophin Homo sapiens 0.322208128632503 0.0698724550898082 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3857214 3803955 3685 Q3079G Dystrophin Homo sapiens -0.0715572545022461 0.101803755753276 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3857215 3803956 3685 Q3079H Dystrophin Homo sapiens -0.0490634765332977 0.104186953835342 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3857216 3803957 3685 Q3079I Dystrophin Homo sapiens 0.587251663815742 0.108065138993639 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3857217 3803958 3685 Q3079K Dystrophin Homo sapiens -0.16094768406748 0.10444375412729 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3857218 3803959 3685 Q3079L Dystrophin Homo sapiens 0.147878157233333 0.0549985689018567 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3857219 3803960 3685 Q3079M Dystrophin Homo sapiens -0.00768194346821036 0.0674805023244618 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3857220 3803961 3685 Q3079N Dystrophin Homo sapiens -0.139113936074613 0.15867559619455 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3857221 3803962 3685 Q3079P Dystrophin Homo sapiens 0.654758205133919 0.0778091943875854 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3857222 3803963 3685 Q3079R Dystrophin Homo sapiens -0.195533217904897 0.0946899904422489 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3857223 3803964 3685 Q3079S Dystrophin Homo sapiens -0.00895924354423185 0.086469477875888 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3857224 3803965 3685 Q3079T Dystrophin Homo sapiens 0.245023701301981 0.110195586668735 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3857225 3803966 3685 Q3079V Dystrophin Homo sapiens 0.493713926977394 0.0400994145374199 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3857226 3803967 3685 Q3079W Dystrophin Homo sapiens 0.425794452680236 0.0558015747838763 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3857227 3803968 3685 Q3079Y Dystrophin Homo sapiens 0.226468172595372 0.0284968597930068 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3858520 3805259 3685 T3080A Dystrophin Homo sapiens 0.0350811378082415 0.0757955564680031 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3858521 3805260 3685 T3080C Dystrophin Homo sapiens -0.0998701185346082 0.0812474443329694 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3858522 3805261 3685 T3080D Dystrophin Homo sapiens 0.227339319845775 0.0871404151970886 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3858523 3805262 3685 T3080E Dystrophin Homo sapiens 0.0681049655557564 0.0663437809690591 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3858524 3805263 3685 T3080F Dystrophin Homo sapiens 0.0594997870597711 0.0769571589033552 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3858525 3805264 3685 T3080G Dystrophin Homo sapiens 0.314619202323807 0.0676703034078626 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3858526 3805265 3685 T3080H Dystrophin Homo sapiens 0.186138081155765 0.112144375791048 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3858527 3805266 3685 T3080I Dystrophin Homo sapiens -0.179339822027011 0.163046377448555 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3858528 3805267 3685 T3080K Dystrophin Homo sapiens 0.0708294837576848 0.0926055206083028 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3858529 3805268 3685 T3080L Dystrophin Homo sapiens -0.0302873309333093 0.0854318172246647 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3858530 3805269 3685 T3080M Dystrophin Homo sapiens -0.0459840977097193 0.07034649080685 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3858531 3805270 3685 T3080N Dystrophin Homo sapiens 0.115987805531892 0.106119229464451 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3858532 3805271 3685 T3080P Dystrophin Homo sapiens 1.00055121421414 0.191016240191798 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3858533 3805272 3685 T3080Q Dystrophin Homo sapiens -0.039123306736508 0.0851605176918342 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3858534 3805273 3685 T3080R Dystrophin Homo sapiens 0.12348659011066 0.0846180536598484 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3858535 3805274 3685 T3080S Dystrophin Homo sapiens -0.0439604785509731 0.102997453442679 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3858536 3805275 3685 T3080V Dystrophin Homo sapiens -0.0792827606217956 0.0984758789582171 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3858537 3805276 3685 T3080W Dystrophin Homo sapiens 0.141728869947935 0.141365032962722 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3858538 3805277 3685 T3080Y Dystrophin Homo sapiens 0.111341494815178 0.155414915532149 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3859831 3806569 3685 T3081A Dystrophin Homo sapiens 0.220703022357703 0.0798205941240002 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3859832 3806570 3685 T3081C Dystrophin Homo sapiens 0.0083758075944951 0.0770904438925323 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3859833 3806571 3685 T3081D Dystrophin Homo sapiens 0.685487312239247 0.136502132731995 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3859834 3806572 3685 T3081E Dystrophin Homo sapiens 0.236654089052508 0.0316670498884861 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3859835 3806573 3685 T3081F Dystrophin Homo sapiens 0.494609931676854 0.101641641074428 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3859836 3806574 3685 T3081G Dystrophin Homo sapiens 0.484082391274086 0.0530947910046336 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3859837 3806575 3685 T3081H Dystrophin Homo sapiens 0.292468255726603 0.176194280078392 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3859838 3806576 3685 T3081I Dystrophin Homo sapiens 0.427425164354044 0.0770765691823981 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3859839 3806577 3685 T3081K Dystrophin Homo sapiens 0.304521249053304 0.0833827273389204 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3859840 3806578 3685 T3081L Dystrophin Homo sapiens 0.44386397268393 0.0539083576453401 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3859841 3806579 3685 T3081M Dystrophin Homo sapiens 0.244625847083405 0.0874998185766309 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3859842 3806580 3685 T3081N Dystrophin Homo sapiens 0.29427862970536 0.0703327218730948 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3859843 3806581 3685 T3081P Dystrophin Homo sapiens 0.628480089285706 0.106193115390437 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3859844 3806582 3685 T3081Q Dystrophin Homo sapiens 0.197819304268831 0.143617225874162 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3859845 3806583 3685 T3081R Dystrophin Homo sapiens 0.299703607609406 0.0434865531114328 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3859846 3806584 3685 T3081S Dystrophin Homo sapiens 0.0266357052753833 0.0783429600003225 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3859847 3806585 3685 T3081V Dystrophin Homo sapiens 0.182296361841476 0.0831007027564314 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3859848 3806586 3685 T3081W Dystrophin Homo sapiens 0.462727490698222 0.0934849499241231 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3859849 3806587 3685 T3081Y Dystrophin Homo sapiens 0.432900070959521 0.0860641292883345 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3861142 3807878 3685 C3082A Dystrophin Homo sapiens 0.293911338108621 0.0728125545543081 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3861143 3807879 3685 C3082D Dystrophin Homo sapiens 0.667382447171051 0.0888226309652063 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3861144 3807880 3685 C3082E Dystrophin Homo sapiens 0.581618734051777 0.0795555849098761 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3861145 3807881 3685 C3082F Dystrophin Homo sapiens 0.676405847464966 0.10485015372695 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3861146 3807882 3685 C3082G Dystrophin Homo sapiens 0.52888236743254 0.0756115280742201 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3861147 3807883 3685 C3082H Dystrophin Homo sapiens 0.247854468500736 0.0760927183254901 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3861148 3807884 3685 C3082I Dystrophin Homo sapiens 0.827935168991167 0.113901152653529 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3861149 3807885 3685 C3082K Dystrophin Homo sapiens 0.566251451693592 0.169499411733671 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3861150 3807886 3685 C3082L Dystrophin Homo sapiens 0.640262880228189 0.0656813451429975 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3861151 3807887 3685 C3082M Dystrophin Homo sapiens 0.349884900783568 0.0943297881134613 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3861152 3807888 3685 C3082N Dystrophin Homo sapiens 0.49290228456656 0.0971097376390888 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3861153 3807889 3685 C3082P Dystrophin Homo sapiens 0.887657446536561 0.0504454145418715 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3861154 3807890 3685 C3082Q Dystrophin Homo sapiens 0.163244573125435 0.0616765332809949 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3861155 3807891 3685 C3082R Dystrophin Homo sapiens 0.540845687146055 0.114670338226296 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3861156 3807892 3685 C3082S Dystrophin Homo sapiens -0.054404353213823 0.0713429425562222 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3861157 3807893 3685 C3082T Dystrophin Homo sapiens -0.136531063696922 0.144724817089966 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3861158 3807894 3685 C3082V Dystrophin Homo sapiens 0.324376454378793 0.110814958005191 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3861159 3807895 3685 C3082W Dystrophin Homo sapiens 0.65309066302518 0.0757165212578665 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3861160 3807896 3685 C3082Y Dystrophin Homo sapiens 0.609169272222076 0.106372721431355 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 8.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3862453 3809188 3685 W3083A Dystrophin Homo sapiens 0.1877012084751 0.0518158454307509 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3862454 3809189 3685 W3083C Dystrophin Homo sapiens 0.184983115625553 0.0775017744719003 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3862455 3809190 3685 W3083D Dystrophin Homo sapiens 0.196617572075749 0.0498457007326929 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3862456 3809191 3685 W3083E Dystrophin Homo sapiens 0.085326254649021 0.0692280721408498 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3862457 3809192 3685 W3083F Dystrophin Homo sapiens -0.0970713093056677 0.100966378174496 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3862458 3809193 3685 W3083G Dystrophin Homo sapiens 0.25982578895951 0.0578904557178814 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3862459 3809194 3685 W3083H Dystrophin Homo sapiens 0.149513662602613 0.0908334736877105 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3862460 3809195 3685 W3083I Dystrophin Homo sapiens 0.234810688087341 0.0886202942556177 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3862461 3809196 3685 W3083K Dystrophin Homo sapiens 0.168016314372548 0.0864579595033873 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3862462 3809197 3685 W3083L Dystrophin Homo sapiens 0.126212436143728 0.0518519388068704 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3862463 3809198 3685 W3083M Dystrophin Homo sapiens 0.0851559377996812 0.0727188749420883 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3862464 3809199 3685 W3083N Dystrophin Homo sapiens 0.228550515648932 0.0890339474142004 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3862465 3809200 3685 W3083P Dystrophin Homo sapiens 0.257633877331273 0.104949500252408 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3862466 3809201 3685 W3083Q Dystrophin Homo sapiens 0.128469373238293 0.0812304807275134 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3862467 3809202 3685 W3083R Dystrophin Homo sapiens 0.18027556038542 0.058397196591074 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3862468 3809203 3685 W3083S Dystrophin Homo sapiens 0.114547615121086 0.0706404028538854 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3862469 3809204 3685 W3083T Dystrophin Homo sapiens -6.1026916651839E-4 0.0941866692968826 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3862470 3809205 3685 W3083V Dystrophin Homo sapiens 0.185752706299346 0.103798822041386 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3862471 3809206 3685 W3083Y Dystrophin Homo sapiens -0.146254050956807 0.100057365230985 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3863764 3810497 3685 D3084A Dystrophin Homo sapiens -0.0247973872028095 0.0897852567789229 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3863765 3810498 3685 D3084C Dystrophin Homo sapiens -0.0721147342789221 0.0909096326805638 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3863766 3810499 3685 D3084E Dystrophin Homo sapiens -0.131849502439279 0.112033096789818 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3863767 3810500 3685 D3084F Dystrophin Homo sapiens -0.00892060253277218 0.111868524498081 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3863768 3810501 3685 D3084G Dystrophin Homo sapiens 0.138582793491018 0.0770440148138513 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3863769 3810502 3685 D3084H Dystrophin Homo sapiens -0.140356984071205 0.0919784129675341 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3863770 3810503 3685 D3084I Dystrophin Homo sapiens -0.111510331920493 0.181367825279081 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3863771 3810504 3685 D3084K Dystrophin Homo sapiens -0.121930975164793 0.087160118860872 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3863772 3810505 3685 D3084L Dystrophin Homo sapiens 0.0362992192035567 0.0958620939964147 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3863773 3810506 3685 D3084M Dystrophin Homo sapiens -0.0545384427786485 0.0711828556330649 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3863774 3810507 3685 D3084N Dystrophin Homo sapiens -0.0143621108092326 0.116754853071467 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3863775 3810508 3685 D3084P Dystrophin Homo sapiens 0.696490868852961 0.164361380389577 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3863776 3810509 3685 D3084Q Dystrophin Homo sapiens -0.0160779004501453 0.0972107990922235 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3863777 3810510 3685 D3084R Dystrophin Homo sapiens 0.014658050049318 0.0636077590232782 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3863778 3810511 3685 D3084S Dystrophin Homo sapiens -0.0374729139045294 0.06997826522719 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3863779 3810512 3685 D3084T Dystrophin Homo sapiens -0.0385636034053125 0.080342921259161 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3863780 3810513 3685 D3084V Dystrophin Homo sapiens -0.137177548670092 0.105523287595935 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3863781 3810514 3685 D3084W Dystrophin Homo sapiens 0.145259415410368 0.0525823978468502 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3863782 3810515 3685 D3084Y Dystrophin Homo sapiens -0.0144241632841425 0.125281014361806 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3865075 3811807 3685 H3085A Dystrophin Homo sapiens 0.28416306579304 0.085531729766279 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3865076 3811808 3685 H3085C Dystrophin Homo sapiens 0.414538473116214 0.0891228670893669 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3865077 3811809 3685 H3085D Dystrophin Homo sapiens 0.284140785236621 0.138543931924555 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3865078 3811810 3685 H3085E Dystrophin Homo sapiens 0.404394608396119 0.109555206342967 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3865079 3811811 3685 H3085F Dystrophin Homo sapiens 0.591299748344266 0.130586026098179 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3865080 3811812 3685 H3085G Dystrophin Homo sapiens 0.587978820157081 0.0837897796013436 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3865081 3811813 3685 H3085I Dystrophin Homo sapiens 0.529254205163014 0.118783430216657 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3865082 3811814 3685 H3085K Dystrophin Homo sapiens 0.234545436937882 0.108290064586539 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3865083 3811815 3685 H3085L Dystrophin Homo sapiens 0.490818658693084 0.0618811824422725 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3865084 3811816 3685 H3085M Dystrophin Homo sapiens 0.346596493206511 0.0862755132541662 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3865085 3811817 3685 H3085N Dystrophin Homo sapiens 0.263181218250728 0.0594099919162765 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3865086 3811818 3685 H3085P Dystrophin Homo sapiens 0.244710018074325 0.0967124348080203 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3865087 3811819 3685 H3085Q Dystrophin Homo sapiens 0.277753759913101 0.0780253270376643 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3865088 3811820 3685 H3085R Dystrophin Homo sapiens 0.176553435896196 0.0780580389454989 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3865089 3811821 3685 H3085S Dystrophin Homo sapiens 0.360059913271426 0.0789400001427306 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3865090 3811822 3685 H3085T Dystrophin Homo sapiens 0.450122524718235 0.0683572726021599 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3865091 3811823 3685 H3085V Dystrophin Homo sapiens 0.397979541079367 0.142911832460154 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3865092 3811824 3685 H3085W Dystrophin Homo sapiens 0.640027730335509 0.141648063546091 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3865093 3811825 3685 H3085Y Dystrophin Homo sapiens 0.390208611882018 0.10393900950193 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3866386 3813117 3685 P3086A Dystrophin Homo sapiens 0.865549429395288 0.113073137409568 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3866387 3813118 3685 P3086C Dystrophin Homo sapiens 0.97496218646365 0.100129360685518 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3866388 3813119 3685 P3086D Dystrophin Homo sapiens 0.937759024831088 0.125190890636368 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3866389 3813120 3685 P3086E Dystrophin Homo sapiens 0.609015333832266 0.117102092167429 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3866390 3813121 3685 P3086F Dystrophin Homo sapiens 1.14354404437385 0.0680127656875614 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3866391 3813122 3685 P3086G Dystrophin Homo sapiens 0.738204976694459 0.0629609398417617 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3866392 3813123 3685 P3086H Dystrophin Homo sapiens 0.867491258656922 0.0888594051361053 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3866393 3813124 3685 P3086I Dystrophin Homo sapiens 0.911741906571564 0.113378797386352 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3866394 3813125 3685 P3086K Dystrophin Homo sapiens 0.969472246108992 0.164068042235662 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3866395 3813126 3685 P3086L Dystrophin Homo sapiens 0.883113372065958 0.0897354361044313 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3866396 3813127 3685 P3086M Dystrophin Homo sapiens 0.789301426844357 0.086186481050937 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3866397 3813128 3685 P3086N Dystrophin Homo sapiens 1.11222406366395 0.159903243600478 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3866398 3813129 3685 P3086Q Dystrophin Homo sapiens 0.733678917966698 0.195303491864841 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3866399 3813130 3685 P3086R Dystrophin Homo sapiens 0.950483248051953 0.164808780714172 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3866400 3813131 3685 P3086S Dystrophin Homo sapiens 0.833486358370367 0.0818786254896088 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3866401 3813132 3685 P3086T Dystrophin Homo sapiens 0.89465747973459 0.0985810308064319 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3866402 3813133 3685 P3086V Dystrophin Homo sapiens 0.800497440203752 0.0826247990735484 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3866403 3813134 3685 P3086W Dystrophin Homo sapiens 1.10055089756017 0.155801089337814 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 3866404 3813135 3685 P3086Y Dystrophin Homo sapiens 1.17624604973893 0.153911450591672 P11532 IPR001589:Actinin_actin-bd_CS, IPR001715:CH_dom, IPR036872:CH_dom_sf, IPR035436:Dystrophin/utrophin, IPR011992:EF-hand-dom_pair, IPR015153:EF-hand_dom_typ1, IPR015154:EF-hand_dom_typ2, IPR050774:KCMF1/Dystrophin, IPR018159:Spectrin/alpha-actinin, IPR002017:Spectrin_repeat, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR000433:Znf_ZZ, IPR043145:Znf_ZZ_sf 9.0 1DXX 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 17911 177 364 Fructose-bisphosphate aldolase A Oryctolagus cuniculus 61.0 yes 4.0 55.7 sodium phosphate 10 mM DSC Thermal 7.4 4.1.2.13 P00883 IPR029768:Aldolase_I_AS, IPR013785:Aldolase_TIM, IPR000741:FBA_I 7833800 10.1002/pro.5560030904 1994 ProTherm 17912 177 364 Fructose-bisphosphate aldolase A Oryctolagus cuniculus 119.0 yes 4.0 58.7 sodium phosphate 10 mM DSC Thermal 7.4 4.1.2.13 P00883 IPR029768:Aldolase_I_AS, IPR013785:Aldolase_TIM, IPR000741:FBA_I 7833800 10.1002/pro.5560030904 1994 ProTherm 17913 177 364 Fructose-bisphosphate aldolase A Oryctolagus cuniculus 34.0 yes 4.0 61.2 sodium phosphate 10 mM DSC Thermal 7.4 4.1.2.13 P00883 IPR029768:Aldolase_I_AS, IPR013785:Aldolase_TIM, IPR000741:FBA_I 7833800 10.1002/pro.5560030904 1994 ProTherm 280 151 364 D129G Fructose-bisphosphate aldolase A Oryctolagus cuniculus 67.0 -11.7 yes 3.0 44.0 sodium phosphate 10 mM DSC Thermal 7.4 4.1.2.13 P00883 IPR029768:Aldolase_I_AS, IPR013785:Aldolase_TIM, IPR000741:FBA_I 9.0 1ADO 9.50888893339369, 9.176666736602783, 9.087777773539225, 10.368888854980469 in pocket 7833800 10.1002/pro.5560030904 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 285 151 364 D129G Fructose-bisphosphate aldolase A Oryctolagus cuniculus 73.0 -12.7 yes 3.0 46.0 sodium phosphate 10 mM DSC Thermal 7.4 4.1.2.13 P00883 IPR029768:Aldolase_I_AS, IPR013785:Aldolase_TIM, IPR000741:FBA_I 9.0 1ADO 9.50888893339369, 9.176666736602783, 9.087777773539225, 10.368888854980469 in pocket 7833800 10.1002/pro.5560030904 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 281 152 364 D129A Fructose-bisphosphate aldolase A Oryctolagus cuniculus 75.0 -10.7 yes 3.0 45.0 sodium phosphate 10 mM DSC Thermal 7.4 4.1.2.13 P00883 IPR029768:Aldolase_I_AS, IPR013785:Aldolase_TIM, IPR000741:FBA_I 9.0 1ADO 9.50888893339369, 9.176666736602783, 9.087777773539225, 10.368888854980469 in pocket 7833800 10.1002/pro.5560030904 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 286 152 364 D129A Fructose-bisphosphate aldolase A Oryctolagus cuniculus 71.0 -11.9 yes 3.0 46.8 sodium phosphate 10 mM DSC Thermal 7.4 4.1.2.13 P00883 IPR029768:Aldolase_I_AS, IPR013785:Aldolase_TIM, IPR000741:FBA_I 9.0 1ADO 9.50888893339369, 9.176666736602783, 9.087777773539225, 10.368888854980469 in pocket 7833800 10.1002/pro.5560030904 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 282 153 364 D129N Fructose-bisphosphate aldolase A Oryctolagus cuniculus 80.0 -10.1 yes 3.0 45.6 sodium phosphate 10 mM DSC Thermal 7.4 4.1.2.13 P00883 IPR029768:Aldolase_I_AS, IPR013785:Aldolase_TIM, IPR000741:FBA_I 9.0 1ADO 9.50888893339369, 9.176666736602783, 9.087777773539225, 10.368888854980469 in pocket 7833800 10.1002/pro.5560030904 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 287 153 364 D129N Fructose-bisphosphate aldolase A Oryctolagus cuniculus 83.0 -11.7 yes 3.0 47.0 sodium phosphate 10 mM DSC Thermal 7.4 4.1.2.13 P00883 IPR029768:Aldolase_I_AS, IPR013785:Aldolase_TIM, IPR000741:FBA_I 9.0 1ADO 9.50888893339369, 9.176666736602783, 9.087777773539225, 10.368888854980469 in pocket 7833800 10.1002/pro.5560030904 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 283 154 364 D129Q Fructose-bisphosphate aldolase A Oryctolagus cuniculus 67.0 -9.8 yes 3.0 45.9 sodium phosphate 10 mM DSC Thermal 7.4 4.1.2.13 P00883 IPR029768:Aldolase_I_AS, IPR013785:Aldolase_TIM, IPR000741:FBA_I 9.0 1ADO 9.50888893339369, 9.176666736602783, 9.087777773539225, 10.368888854980469 in pocket 7833800 10.1002/pro.5560030904 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 288 154 364 D129Q Fructose-bisphosphate aldolase A Oryctolagus cuniculus 77.0 -11.6 yes 3.0 47.1 sodium phosphate 10 mM DSC Thermal 7.4 4.1.2.13 P00883 IPR029768:Aldolase_I_AS, IPR013785:Aldolase_TIM, IPR000741:FBA_I 9.0 1ADO 9.50888893339369, 9.176666736602783, 9.087777773539225, 10.368888854980469 in pocket 7833800 10.1002/pro.5560030904 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 284 155 364 D129V Fructose-bisphosphate aldolase A Oryctolagus cuniculus 91.0 -11.8 yes 3.0 43.9 sodium phosphate 10 mM DSC Thermal 7.4 4.1.2.13 P00883 IPR029768:Aldolase_I_AS, IPR013785:Aldolase_TIM, IPR000741:FBA_I 9.0 1ADO 9.50888893339369, 9.176666736602783, 9.087777773539225, 10.368888854980469 in pocket 7833800 10.1002/pro.5560030904 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 289 155 364 D129V Fructose-bisphosphate aldolase A Oryctolagus cuniculus 78.0 -12.2 yes 3.0 46.5 sodium phosphate 10 mM DSC Thermal 7.4 4.1.2.13 P00883 IPR029768:Aldolase_I_AS, IPR013785:Aldolase_TIM, IPR000741:FBA_I 9.0 1ADO 9.50888893339369, 9.176666736602783, 9.087777773539225, 10.368888854980469 in pocket 7833800 10.1002/pro.5560030904 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 17732 183 155 Ribonuclease HI Escherichia coli (strain K12) 41.2 yes (95%) 23.6 glycine-HCl 10 mM CD Thermal 0.53 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17733 183 155 Ribonuclease HI Escherichia coli (strain K12) 37.3 yes (96%) 23.9 glycine-HCl 10 mM CD Thermal 0.83 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17734 183 155 Ribonuclease HI Escherichia coli (strain K12) 34.7 yes (98%) 20.4 glycine-HCl 10 mM CD Thermal 1.02 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17735 183 155 Ribonuclease HI Escherichia coli (strain K12) 35.3 yes (88%) 24.9 glycine-HCl 10 mM CD Thermal 1.07 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17736 183 155 Ribonuclease HI Escherichia coli (strain K12) 49.6 yes (102%) 22.3 glycine-HCl 10 mM CD Thermal 1.08 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17737 183 155 Ribonuclease HI Escherichia coli (strain K12) 51.5 yes (101%) 21.5 glycine-HCl 10 mM CD Thermal 1.14 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17738 183 155 Ribonuclease HI Escherichia coli (strain K12) 48.7 yes (103%) 21.5 glycine-HCl 10 mM CD Thermal 1.24 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17739 183 155 Ribonuclease HI Escherichia coli (strain K12) 52.7 yes (100%) 23.0 glycine-HCl 10 mM CD Thermal 1.28 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17740 183 155 Ribonuclease HI Escherichia coli (strain K12) 56.9 yes (101%) 21.2 glycine-HCl 10 mM CD Thermal 1.3 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17741 183 155 Ribonuclease HI Escherichia coli (strain K12) 45.5 yes (94%) 20.9 glycine-HCl 10 mM CD Thermal 1.31 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17742 183 155 Ribonuclease HI Escherichia coli (strain K12) 52.9 yes (91%) 20.3 glycine-HCl 10 mM CD Thermal 1.4 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17743 183 155 Ribonuclease HI Escherichia coli (strain K12) 46.1 yes (98%) 21.0 glycine-HCl 10 mM CD Thermal 1.41 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17744 183 155 Ribonuclease HI Escherichia coli (strain K12) 52.0 yes (101%) 21.8 glycine-HCl 10 mM CD Thermal 1.45 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17745 183 155 Ribonuclease HI Escherichia coli (strain K12) 55.3 yes (107%) 21.5 glycine-HCl 10 mM CD Thermal 1.52 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17746 183 155 Ribonuclease HI Escherichia coli (strain K12) 54.4 yes (104%) 20.8 glycine-HCl 10 mM CD Thermal 1.55 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17747 183 155 Ribonuclease HI Escherichia coli (strain K12) 53.4 yes (93%) 21.7 glycine-HCl 10 mM CD Thermal 1.55 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17748 183 155 Ribonuclease HI Escherichia coli (strain K12) 56.4 yes (100%) 20.6 glycine-HCl 10 mM CD Thermal 1.62 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17749 183 155 Ribonuclease HI Escherichia coli (strain K12) 55.7 yes (108%) 21.9 glycine-HCl 10 mM CD Thermal 1.63 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17750 183 155 Ribonuclease HI Escherichia coli (strain K12) 70.6 yes (108%) 23.6 glycine-HCl 10 mM CD Thermal 1.67 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17751 183 155 Ribonuclease HI Escherichia coli (strain K12) 63.3 yes (110%) 22.9 glycine-HCl 10 mM CD Thermal 1.69 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17752 183 155 Ribonuclease HI Escherichia coli (strain K12) 58.3 yes (98%) 21.1 glycine-HCl 10 mM CD Thermal 1.71 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17753 183 155 Ribonuclease HI Escherichia coli (strain K12) 72.5 yes (90%) 21.7 glycine-HCl 10 mM CD Thermal 1.75 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17754 183 155 Ribonuclease HI Escherichia coli (strain K12) 78.5 yes (101%) 25.2 glycine-HCl 10 mM CD Thermal 1.76 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17755 183 155 Ribonuclease HI Escherichia coli (strain K12) 60.7 yes (104%) 23.9 glycine-HCl 10 mM CD Thermal 1.79 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17756 183 155 Ribonuclease HI Escherichia coli (strain K12) 64.8 yes (110%) 23.9 glycine-HCl 10 mM CD Thermal 1.84 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17757 183 155 Ribonuclease HI Escherichia coli (strain K12) 74.6 yes (88%) 24.8 glycine-HCl 10 mM CD Thermal 1.94 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17758 183 155 Ribonuclease HI Escherichia coli (strain K12) 61.3 yes (98%) 26.5 glycine-HCl 10 mM CD Thermal 2.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17759 183 155 Ribonuclease HI Escherichia coli (strain K12) 67.9 yes (109%) 28.7 glycine-HCl 10 mM CD Thermal 2.03 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17760 183 155 Ribonuclease HI Escherichia coli (strain K12) 70.6 yes (95%) 28.5 glycine-HCl 10 mM CD Thermal 2.04 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17761 183 155 Ribonuclease HI Escherichia coli (strain K12) 67.1 yes (92%) 29.9 glycine-HCl 10 mM CD Thermal 2.15 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17762 183 155 Ribonuclease HI Escherichia coli (strain K12) 63.5 yes (90%) 32.5 glycine-HCl 10 mM CD Thermal 2.18 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17763 183 155 Ribonuclease HI Escherichia coli (strain K12) 65.8 yes (95%) 33.0 glycine-HCl 10 mM CD Thermal 2.22 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17764 183 155 Ribonuclease HI Escherichia coli (strain K12) 68.5 yes (90%) 33.0 glycine-HCl 10 mM CD Thermal 2.26 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17765 183 155 Ribonuclease HI Escherichia coli (strain K12) 66.7 yes (95%) 35.5 glycine-HCl 10 mM CD Thermal 2.39 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17766 183 155 Ribonuclease HI Escherichia coli (strain K12) 71.8 yes (96%) 35.4 glycine-HCl 10 mM CD Thermal 2.45 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17767 183 155 Ribonuclease HI Escherichia coli (strain K12) 76.0 yes (92%) 39.8 glycine-HCl 10 mM CD Thermal 2.53 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17768 183 155 Ribonuclease HI Escherichia coli (strain K12) 81.3 yes (91%) 42.3 glycine-HCl 10 mM CD Thermal 2.65 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17769 183 155 Ribonuclease HI Escherichia coli (strain K12) 89.0 yes (92%) 46.1 glycine-HCl 10 mM CD Thermal 2.79 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17770 183 155 Ribonuclease HI Escherichia coli (strain K12) 93.0 yes (92%) 46.7 glycine-HCl 10 mM CD Thermal 2.82 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17771 183 155 Ribonuclease HI Escherichia coli (strain K12) 80.5 yes (97%) 46.4 glycine-HCl 10 mM CD Thermal 2.86 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17772 183 155 Ribonuclease HI Escherichia coli (strain K12) 91.6 yes (92%) 50.1 glycine-HCl 10 mM CD Thermal 2.95 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17773 183 155 Ribonuclease HI Escherichia coli (strain K12) 101.6 yes (90%) 50.7 glycine-HCl 10 mM CD Thermal 3.06 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17774 183 155 Ribonuclease HI Escherichia coli (strain K12) 105.6 yes (85%) 53.9 glycine-HCl 10 mM CD Thermal 3.1 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17775 183 155 Ribonuclease HI Escherichia coli (strain K12) 100.7 yes (91%) 52.2 glycine-HCl 10 mM CD Thermal 3.11 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17776 183 155 Ribonuclease HI Escherichia coli (strain K12) 101.9 yes (93%) 54.0 glycine-HCl 10 mM CD Thermal 3.18 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17777 183 155 Ribonuclease HI Escherichia coli (strain K12) 109.4 yes (94%) 55.1 glycine-HCl 10 mM CD Thermal 3.25 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17778 183 155 Ribonuclease HI Escherichia coli (strain K12) 96.6 yes (95%) 58.9 glycine-HCl 10 mM CD Thermal 3.26 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17779 183 155 Ribonuclease HI Escherichia coli (strain K12) 100.0 yes (94%) 57.6 glycine-HCl 10 mM CD Thermal 3.34 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17780 183 155 Ribonuclease HI Escherichia coli (strain K12) 101.2 yes (96%) 57.4 glycine-HCl 10 mM CD Thermal 3.38 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17781 183 155 Ribonuclease HI Escherichia coli (strain K12) 106.2 yes (93%) 62.1 glycine-HCl 10 mM CD Thermal 3.64 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17782 183 155 Ribonuclease HI Escherichia coli (strain K12) 103.4 yes (94%) 62.3 glycine-HCl 10 mM CD Thermal 3.66 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17783 183 155 Ribonuclease HI Escherichia coli (strain K12) 125.2 yes (93%) 66.0 glycine-HCl 10 mM CD Thermal 3.98 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17784 183 155 Ribonuclease HI Escherichia coli (strain K12) 112.0 yes (94%) 66.6 glycine-HCl 10 mM CD Thermal 4.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 17785 183 155 Ribonuclease HI Escherichia coli (strain K12) 112.2 yes (96%) 67.7 glycine-HCl 10 mM CD Thermal 4.34 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 18050 183 155 Ribonuclease HI Escherichia coli (strain K12) 99.2 yes 53.0 glycine-HCl 10 mM CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 9228039 10.1074/jbc.272.30.18686 1997 ProTherm 18082 183 155 Ribonuclease HI Escherichia coli (strain K12) yes 47.0 glycine-NaOH 50 mM CD Thermal 9.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8955106 10.1074/jbc.271.51.32729 1996 ProTherm 18083 183 155 Ribonuclease HI Escherichia coli (strain K12) 95.1 yes 50.0 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8955106 10.1074/jbc.271.51.32729 1996 ProTherm 18276 183 155 Ribonuclease HI Escherichia coli (strain K12) 98.1 yes 49.8 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 1328237 1992 ProTherm 18277 183 155 Ribonuclease HI Escherichia coli (strain K12) 89.0 yes 52.0 Sodium acetate 20 mM CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 1328237 1992 ProTherm 18286 183 155 Ribonuclease HI Escherichia coli (strain K12) yes (>90%) 45.6 Potassium phosphate 100 mM KCl 20 mM CD Thermal 8.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 9188727 10.1021/bi970060q 1997 ProTherm 18287 183 155 Ribonuclease HI Escherichia coli (strain K12) yes (>90%) 50.9 Potassium phosphate 100 mM KCl 20 mM CD Thermal 8.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 9188727 10.1021/bi970060q 1997 ProTherm 18288 183 155 Ribonuclease HI Escherichia coli (strain K12) yes 55.0 Potassium phosphate 20 mM KCl 50 mM CD Thermal 8.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7833802 10.1002/pro.5560030906 1994 ProTherm 18542 183 155 Ribonuclease HI Escherichia coli (strain K12) 98.1 yes 49.8 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 1317795 10.1111/j.1432-1033.1992.tb16932.x 1992 ProTherm 19012 183 155 Ribonuclease HI Escherichia coli (strain K12) 2.7 120.0 no 66.0 Sodium acetate 5 mM KCl 50 mM CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 10090773 10.1021/bi982684h 1999 ProTherm 19201 183 155 Ribonuclease HI Escherichia coli (strain K12) 98.1 yes 49.8 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 1331044 1992 ProTherm 19202 183 155 Ribonuclease HI Escherichia coli (strain K12) 89.0 yes 52.0 Sodium acetate 20 mM CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 1331044 1992 ProTherm 19355 183 155 Ribonuclease HI Escherichia coli (strain K12) 105.8 yes 50.9 glycine-HCl 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7794925 10.1021/bi00025a018 1995 ProTherm 19356 183 155 Ribonuclease HI Escherichia coli (strain K12) 81.8 yes 52.5 Sodium acetate 10 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7794925 10.1021/bi00025a018 1995 ProTherm 19374 183 155 Ribonuclease HI Escherichia coli (strain K12) 83.3 yes 53.1 Sodium acetate 20 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm 19375 183 155 Ribonuclease HI Escherichia coli (strain K12) 107.4 yes 50.0 glycine-HCl 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm 19384 183 155 Ribonuclease HI Escherichia coli (strain K12) yes 47.8 Potassium phosphate 2 mM KF 5 mM CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 10467093 10.1038/12277 1999 ProTherm 19385 183 155 Ribonuclease HI Escherichia coli (strain K12) yes 49.4 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7764048 10.1016/0168-1656(93)90129-b 1993 ProTherm 19386 183 155 Ribonuclease HI Escherichia coli (strain K12) yes 52.7 Sodium acetate 20 mM CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7764048 10.1016/0168-1656(93)90129-b 1993 ProTherm 19387 183 155 Ribonuclease HI Escherichia coli (strain K12) yes 50.2 Sodium phosphate 20 mM CD Thermal 7.8 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7764048 10.1016/0168-1656(93)90129-b 1993 ProTherm 19479 183 155 Ribonuclease HI Escherichia coli (strain K12) yes 49.8 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8393706 10.1021/bi00079a010 1993 ProTherm 19513 183 155 Ribonuclease HI Escherichia coli (strain K12) yes 49.8 glycine-HCl 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3191114 10.1021/bi00416a052 1988 ProTherm 19514 183 155 Ribonuclease HI Escherichia coli (strain K12) yes 52.0 Sodium acetate 20 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3191114 10.1021/bi00416a052 1988 ProTherm 19532 183 155 Ribonuclease HI Escherichia coli (strain K12) 100.7 yes 52.7 Sodium acetate 20 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7929430 1994 ProTherm 19533 183 155 Ribonuclease HI Escherichia coli (strain K12) 113.2 yes 50.1 glycine-HCl 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7929430 1994 ProTherm 20090 183 155 Ribonuclease HI Escherichia coli (strain K12) yes 49.8 Gly-HCl buffer 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8390295 1993 ProTherm 20091 183 155 Ribonuclease HI Escherichia coli (strain K12) yes 52.0 sodium acetate 20 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8390295 1993 ProTherm 20482 183 155 Ribonuclease HI Escherichia coli (strain K12) 6.08 yes glycine-HCl 10 mM 25.0 CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 20483 183 155 Ribonuclease HI Escherichia coli (strain K12) 10.0 yes glycine-HCl 10 mM 25.0 CD Thermal 4.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 20706 183 155 Ribonuclease HI Escherichia coli (strain K12) 1.83 9.15 5.01 yes Sodium acetate 20 mM 25.0 CD GdnHCl 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 1328237 1992 ProTherm 20716 183 155 Ribonuclease HI Escherichia coli (strain K12) 1.18 3.95 yes Potassium phosphate 50 mM 25.0 KCl 50 mM CD GdnHCl 8.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7535929 10.1073/pnas.92.7.2740 1995 ProTherm 20717 183 155 Ribonuclease HI Escherichia coli (strain K12) 1.6 7.2 yes Potassium phosphate 20 mM 25.0 KCl 50 mM CD GdnHCl 8.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7833802 10.1002/pro.5560030906 1994 ProTherm 20718 183 155 Ribonuclease HI Escherichia coli (strain K12) 3.84 7.4 yes Potassium phosphate 20 mM 25.0 KCl 50 mM CD Urea 8.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7833802 10.1002/pro.5560030906 1994 ProTherm 20719 183 155 Ribonuclease HI Escherichia coli (strain K12) 3.93 7.6 yes Potassium phosphate 20 mM 25.0 KCl 50 mM Fluorescence Urea 8.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7833802 10.1002/pro.5560030906 1994 ProTherm 20752 183 155 Ribonuclease HI Escherichia coli (strain K12) 1.79 9.26 5.17 yes Sodium acetate 20 mM 25.0 NaCl 0.1 M Fluorescence GdnHCl 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 1645658 10.1111/j.1432-1033.1991.tb16033.x 1991 ProTherm 20770 183 155 Ribonuclease HI Escherichia coli (strain K12) 5.01 9.81 1.96 yes Sodium acetate 10 mM 25.0 NaCl 0.1 M CD Urea 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 1317795 10.1111/j.1432-1033.1992.tb16932.x 1992 ProTherm 20879 183 155 Ribonuclease HI Escherichia coli (strain K12) 0.43 9.47 5.24 no acetate 10 mM 25.0 CD GdnHCl 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8527428 10.1021/bi00051a003 1995 ProTherm 21204 183 155 Ribonuclease HI Escherichia coli (strain K12) 9.7 2.1 yes Potassium phosphate 2 mM 25.0 KF 5 mM CD Urea 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 10467093 10.1038/12277 1999 ProTherm 21205 183 155 Ribonuclease HI Escherichia coli (strain K12) 1.79 9.21 yes Sodium acetate 20 mM 25.0 CD GdnHCl 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7764048 10.1016/0168-1656(93)90129-b 1993 ProTherm 21206 183 155 Ribonuclease HI Escherichia coli (strain K12) 1.65 8.49 yes Tris-HCl 20 mM 25.0 CD GdnHCl 8.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7764048 10.1016/0168-1656(93)90129-b 1993 ProTherm 21413 183 155 Ribonuclease HI Escherichia coli (strain K12) 7.3 Unknown Sodium acetate 100 mM 25.0 NMR GdnHCl 5.1 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8784352 10.1038/nsb0996-782 1996 ProTherm 21414 183 155 Ribonuclease HI Escherichia coli (strain K12) 7.6 Unknown Sodium acetate 100 mM 25.0 NMR GdnHCl 5.1 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8784352 10.1038/nsb0996-782 1996 ProTherm 21415 183 155 Ribonuclease HI Escherichia coli (strain K12) 7.0 Unknown Sodium acetate 100 mM 25.0 NMR GdnHCl 5.1 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8784352 10.1038/nsb0996-782 1996 ProTherm 21416 183 155 Ribonuclease HI Escherichia coli (strain K12) 8.4 Unknown Sodium acetate 100 mM 25.0 NMR GdnHCl 5.1 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8784352 10.1038/nsb0996-782 1996 ProTherm 21417 183 155 Ribonuclease HI Escherichia coli (strain K12) 7.5 Unknown Sodium acetate 100 mM 25.0 NMR GdnHCl 5.1 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8784352 10.1038/nsb0996-782 1996 ProTherm 21418 183 155 Ribonuclease HI Escherichia coli (strain K12) 8.0 Unknown Sodium acetate 100 mM 25.0 NMR GdnHCl 5.1 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8784352 10.1038/nsb0996-782 1996 ProTherm 21419 183 155 Ribonuclease HI Escherichia coli (strain K12) 7.2 Unknown Sodium acetate 100 mM 25.0 NMR GdnHCl 5.1 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8784352 10.1038/nsb0996-782 1996 ProTherm 21420 183 155 Ribonuclease HI Escherichia coli (strain K12) 6.7 Unknown Sodium acetate 100 mM 25.0 NMR GdnHCl 5.1 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8784352 10.1038/nsb0996-782 1996 ProTherm 21421 183 155 Ribonuclease HI Escherichia coli (strain K12) 7.4 Unknown Sodium acetate 100 mM 25.0 NMR GdnHCl 5.1 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8784352 10.1038/nsb0996-782 1996 ProTherm 21422 183 155 Ribonuclease HI Escherichia coli (strain K12) 7.7 Unknown Sodium acetate 100 mM 25.0 NMR GdnHCl 5.1 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8784352 10.1038/nsb0996-782 1996 ProTherm 21423 183 155 Ribonuclease HI Escherichia coli (strain K12) 9.2 Unknown Sodium acetate 100 mM 25.0 NMR GdnHCl 5.1 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8784352 10.1038/nsb0996-782 1996 ProTherm 21424 183 155 Ribonuclease HI Escherichia coli (strain K12) 9.8 Unknown Sodium acetate 100 mM 25.0 NMR GdnHCl 5.1 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8784352 10.1038/nsb0996-782 1996 ProTherm 21425 183 155 Ribonuclease HI Escherichia coli (strain K12) 9.3 Unknown Sodium acetate 100 mM 25.0 NMR GdnHCl 5.1 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8784352 10.1038/nsb0996-782 1996 ProTherm 21426 183 155 Ribonuclease HI Escherichia coli (strain K12) 11.1 Unknown Sodium acetate 100 mM 25.0 NMR GdnHCl 5.1 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8784352 10.1038/nsb0996-782 1996 ProTherm 21427 183 155 Ribonuclease HI Escherichia coli (strain K12) 10.9 Unknown Sodium acetate 100 mM 25.0 NMR GdnHCl 5.1 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8784352 10.1038/nsb0996-782 1996 ProTherm 21428 183 155 Ribonuclease HI Escherichia coli (strain K12) 10.5 Unknown Sodium acetate 100mM 25.0 NMR GdnHCl 5.1 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8784352 10.1038/nsb0996-782 1996 ProTherm 21429 183 155 Ribonuclease HI Escherichia coli (strain K12) 10.7 Unknown Sodium acetate 100mM 25.0 NMR GdnHCl 5.1 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8784352 10.1038/nsb0996-782 1996 ProTherm 21430 183 155 Ribonuclease HI Escherichia coli (strain K12) 10.7 Unknown Sodium acetate 100 mM 25.0 NMR GdnHCl 5.1 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8784352 10.1038/nsb0996-782 1996 ProTherm 21431 183 155 Ribonuclease HI Escherichia coli (strain K12) 9.0 Unknown Sodium acetate 100 mM 25.0 NMR GdnHCl 5.1 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8784352 10.1038/nsb0996-782 1996 ProTherm 21432 183 155 Ribonuclease HI Escherichia coli (strain K12) 10.0 Unknown Sodium acetate 100 mM 25.0 NMR GdnHCl 5.1 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8784352 10.1038/nsb0996-782 1996 ProTherm 21433 183 155 Ribonuclease HI Escherichia coli (strain K12) 9.1 Unknown Sodium acetate 100 mM 25.0 NMR GdnHCl 5.1 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8784352 10.1038/nsb0996-782 1996 ProTherm 21434 183 155 Ribonuclease HI Escherichia coli (strain K12) 8.3 Unknown Sodium acetate 100 mM 25.0 NMR GdnHCl 5.1 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8784352 10.1038/nsb0996-782 1996 ProTherm 21435 183 155 Ribonuclease HI Escherichia coli (strain K12) 6.9 Unknown Sodium acetate 100 mM 25.0 NMR GdnHCl 5.1 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8784352 10.1038/nsb0996-782 1996 ProTherm 21436 183 155 Ribonuclease HI Escherichia coli (strain K12) 8.6 Unknown Sodium acetate 100 mM 25.0 NMR GdnHCl 5.1 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8784352 10.1038/nsb0996-782 1996 ProTherm 21437 183 155 Ribonuclease HI Escherichia coli (strain K12) 9.9 Unknown Sodium acetate 100 mM 25.0 NMR GdnHCl 5.1 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8784352 10.1038/nsb0996-782 1996 ProTherm 21438 183 155 Ribonuclease HI Escherichia coli (strain K12) 10.1 Unknown Sodium acetate 100 mM 25.0 NMR GdnHCl 5.1 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8784352 10.1038/nsb0996-782 1996 ProTherm 21439 183 155 Ribonuclease HI Escherichia coli (strain K12) 8.9 Unknown Sodium acetate 100 mM 25.0 NMR GdnHCl 5.1 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8784352 10.1038/nsb0996-782 1996 ProTherm 21440 183 155 Ribonuclease HI Escherichia coli (strain K12) 10.2 Unknown Sodium acetate 100 mM 25.0 NMR GdnHCl 5.1 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8784352 10.1038/nsb0996-782 1996 ProTherm 21441 183 155 Ribonuclease HI Escherichia coli (strain K12) 7.8 Unknown Sodium acetate 100 mM 25.0 NMR GdnHCl 5.1 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8784352 10.1038/nsb0996-782 1996 ProTherm 21442 183 155 Ribonuclease HI Escherichia coli (strain K12) 6.5 Unknown Sodium acetate 100 mM 25.0 NMR GdnHCl 5.1 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8784352 10.1038/nsb0996-782 1996 ProTherm 21445 183 155 Ribonuclease HI Escherichia coli (strain K12) 2.7 7.5 no Sodium acetate 5 mM 24.0 KCl 50 mM CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 10090773 10.1021/bi982684h 1999 ProTherm 21952 183 155 Ribonuclease HI Escherichia coli (strain K12) 8.14 yes glycine-HCl 10 mM 10.0 CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 21953 183 155 Ribonuclease HI Escherichia coli (strain K12) 12.0 yes glycine/HCl 10 mM 10.0 CD Thermal 4.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 21954 183 155 Ribonuclease HI Escherichia coli (strain K12) 2.0 yes glycine-HCl 10 mM 10.0 CD Thermal 2.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI DOI: 10.1016/0040-6031(95)02495-6 ProTherm 22428 183 155 Ribonuclease HI Escherichia coli (strain K12) 2.7 yes 66.0 NaOAc 20 mM KCl 50 mM CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 11790848 10.1110/ps.38602 2002 ProTherm 25714 183 155 Ribonuclease HI Escherichia coli (strain K12) 7.6 4.9 yes NaOAc 20 mM 25.0 KCl 50 mM CD GdnHCl 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 11790848 10.1110/ps.38602 2002 ProTherm 25715 183 155 Ribonuclease HI Escherichia coli (strain K12) 9.7 2.1 yes NaOAc 20 mM 25.0 KCl 50 mM CD Urea 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 11790848 10.1110/ps.38602 2002 ProTherm 759 466 155 D10N Ribonuclease HI Escherichia coli (strain K12) 6.8 yes 53.8 glycine-NaOH 50 mM CD Thermal 9.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 13.770000100135803 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 772 466 155 D10N Ribonuclease HI Escherichia coli (strain K12) 90.5 -2.6 yes 47.4 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 13.770000100135803 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7676 466 155 D10N Ribonuclease HI Escherichia coli (strain K12) 0.7 yes glycine-HCl 10 mM 50.0 CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 13.770000100135803 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 7798 466 155 D10N Ribonuclease HI Escherichia coli (strain K12) -2.0 yes glycine-NaOH 50 mM 47.0 CD Thermal 9.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 13.770000100135803 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm capriotti_S1615_map.csv 760 467 155 D10A Ribonuclease HI Escherichia coli (strain K12) 13.7 yes 60.7 glycine-NaOH 50 mM CD Thermal 9.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 13.770000100135803 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 773 467 155 D10A Ribonuclease HI Escherichia coli (strain K12) 105.3 8.1 yes 58.1 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 13.770000100135803 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3962 467 155 D10A Ribonuclease HI Escherichia coli (strain K12) 14.8 yes 62.6 Potassium phosphate 2 mM KF 5 mM CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 13.770000100135803 in tunnel in pocket 10467093 10.1038/12277 1999 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7677 467 155 D10A Ribonuclease HI Escherichia coli (strain K12) -2.4 yes glycine-HCl 10 mM 50.0 CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 13.770000100135803 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 7799 467 155 D10A Ribonuclease HI Escherichia coli (strain K12) -4.0 yes glycine-NaOH 50 mM 47.0 CD Thermal 9.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 13.770000100135803 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm capriotti_S1615_map.csv 11062 467 155 D10A Ribonuclease HI Escherichia coli (strain K12) -3.3 13.0 2.1 yes Potassium phosphate 2 mM 25.0 KF 5 mM CD Urea 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 13.770000100135803 in tunnel in pocket 10467093 10.1038/12277 1999 ProTherm potapov_with_uniprot_mapping.csv, SAAFEC_S1262.csv 761 468 155 D10E Ribonuclease HI Escherichia coli (strain K12) 3.4 yes 50.4 glycine-NaOH 50 mM CD Thermal 9.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 13.770000100135803 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 774 468 155 D10E Ribonuclease HI Escherichia coli (strain K12) 97.7 3.8 yes 53.8 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 13.770000100135803 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S499.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7678 468 155 D10E Ribonuclease HI Escherichia coli (strain K12) -1.1 yes glycine-HCl 10 mM 50.0 CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 13.770000100135803 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 7800 468 155 D10E Ribonuclease HI Escherichia coli (strain K12) -1.0 yes glycine-NaOH 50 mM 47.0 CD Thermal 9.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 13.770000100135803 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 762 469 155 D10S Ribonuclease HI Escherichia coli (strain K12) 9.2 yes 56.2 glycine-NaOH 50 mM CD Thermal 9.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 13.770000100135803 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm HotMuSiC_S1626.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 775 469 155 D10S Ribonuclease HI Escherichia coli (strain K12) 120.7 2.4 yes 52.4 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 13.770000100135803 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7679 469 155 D10S Ribonuclease HI Escherichia coli (strain K12) -0.7 yes glycine-HCl 10 mM 50.0 CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 13.770000100135803 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 7801 469 155 D10S Ribonuclease HI Escherichia coli (strain K12) -2.7 yes glycine-NaOH 50 mM 47.0 CD Thermal 9.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 13.770000100135803 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm capriotti_S1615_map.csv 763 470 155 D10H Ribonuclease HI Escherichia coli (strain K12) 8.2 yes 55.2 glycine-NaOH 50 mM CD Thermal 9.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 13.770000100135803 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm HotMuSiC_S1626.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 776 470 155 D10H Ribonuclease HI Escherichia coli (strain K12) 114.6 1.5 yes 51.5 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 13.770000100135803 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7680 470 155 D10H Ribonuclease HI Escherichia coli (strain K12) -0.4 yes glycine-HCl 10 mM 50.0 CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 13.770000100135803 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 7802 470 155 D10H Ribonuclease HI Escherichia coli (strain K12) -2.4 yes glycine-NaOH 50 mM 47.0 CD Thermal 9.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 13.770000100135803 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm capriotti_S1615_map.csv 3924 2025 155 G23A Ribonuclease HI Escherichia coli (strain K12) 99.3 2.3 yes 53.2 glycine-HCl 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 10.042500257492065 7794925 10.1021/bi00025a018 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3928 2025 155 G23A Ribonuclease HI Escherichia coli (strain K12) 91.8 1.8 yes 54.3 Sodium acetate 10 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 10.042500257492065 7794925 10.1021/bi00025a018 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4080 2025 155 G23A Ribonuclease HI Escherichia coli (strain K12) 91.8 1.8 yes 54.5 Sodium acetate 20 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 10.042500257492065 7929430 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4093 2025 155 G23A Ribonuclease HI Escherichia coli (strain K12) 99.3 2.3 yes 52.4 glycine-HCl 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 10.042500257492065 7929430 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7420 2025 155 G23A Ribonuclease HI Escherichia coli (strain K12) -0.5 yes Sodium acetate 20 mM 52.7 NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 10.042500257492065 7929430 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 7455 2025 155 G23A Ribonuclease HI Escherichia coli (strain K12) -0.5 yes Sodium acetate 10 mM 52.5 NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 10.042500257492065 7794925 10.1021/bi00025a018 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 7619 2025 155 G23A Ribonuclease HI Escherichia coli (strain K12) -0.7 yes glycine-HCl 10 mM 50.9 NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 10.042500257492065 7794925 10.1021/bi00025a018 1995 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 7654 2025 155 G23A Ribonuclease HI Escherichia coli (strain K12) -0.7 yes glycine-HCl 10 mM 50.1 NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 10.042500257492065 7929430 1994 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 4081 2071 155 A24V Ribonuclease HI Escherichia coli (strain K12) 101.2 3.2 yes 55.9 Sodium acetate 20 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 6.0 2RN2 11.018000030517578 7929430 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4094 2071 155 A24V Ribonuclease HI Escherichia coli (strain K12) 108.7 2.4 yes 52.5 glycine-HCl 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 6.0 2RN2 11.018000030517578 7929430 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7421 2071 155 A24V Ribonuclease HI Escherichia coli (strain K12) -0.88 yes Sodium acetate 20 mM 52.7 NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 6.0 2RN2 11.018000030517578 7929430 1994 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 7655 2071 155 A24V Ribonuclease HI Escherichia coli (strain K12) -0.73 yes glycine-HCl 10 mM 50.1 NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 6.0 2RN2 11.018000030517578 7929430 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3963 2043 155 R27A Ribonuclease HI Escherichia coli (strain K12) -5.6 yes 42.2 Potassium phosphate 2 mM KF 5 mM CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 4.0 2RN2 25.050908868963067 in pocket 10467093 10.1038/12277 1999 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 11063 2043 155 R27A Ribonuclease HI Escherichia coli (strain K12) 2.2 7.5 2.0 yes Potassium phosphate 2 mM 25.0 KF 5 mM CD Urea 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 4.0 2RN2 25.050908868963067 in pocket 10467093 10.1038/12277 1999 ProTherm SAAFEC_S1262.csv 14667 6841 155 Y28F, R29H, G30A, R31H Ribonuclease HI Escherichia coli (strain K12) 92.5 -2.3 yes 47.5 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0, 3.0, 1.0, 3.0 2RN2 26.046666781107586, 40.39272759177468, 34.99250030517578, 33.27909140153365 in pocket 1328237 1992 ProTherm 14668 6841 155 Y28F, R29H, G30A, R31H Ribonuclease HI Escherichia coli (strain K12) 80.5 -3.2 yes 48.8 glycine-HCl 10 mM CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0, 3.0, 1.0, 3.0 2RN2 26.046666781107586, 40.39272759177468, 34.99250030517578, 33.27909140153365 in pocket 1328237 1992 ProTherm 14997 6841 155 Y28F, R29H, G30A, R31H Ribonuclease HI Escherichia coli (strain K12) 0.9 yes glycine-HCl 10 mM 52.0 CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0, 3.0, 1.0, 3.0 2RN2 26.046666781107586, 40.39272759177468, 34.99250030517578, 33.27909140153365 in pocket 1328237 1992 ProTherm 15058 6841 155 Y28F, R29H, G30A, R31H Ribonuclease HI Escherichia coli (strain K12) 0.7 yes glycine-HCl 10 mM 49.8 CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0, 3.0, 1.0, 3.0 2RN2 26.046666781107586, 40.39272759177468, 34.99250030517578, 33.27909140153365 in pocket 1328237 1992 ProTherm 14784 6931 155 H62P, T40A, K122R Ribonuclease HI Escherichia coli (strain K12) 96.9 3.1 yes 55.8 Sodium acetate 20 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 2.0, 3.0, 7.0 2RN2 18.57285717555455, 26.803000068664552, 29.957777871025932 in tunnel in pocket 7929430 1994 ProTherm 14788 6931 155 H62P, T40A, K122R Ribonuclease HI Escherichia coli (strain K12) 108.6 1.7 yes 51.8 glycine-HCl 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 2.0, 3.0, 7.0 2RN2 18.57285717555455, 26.803000068664552, 29.957777871025932 in tunnel in pocket 7929430 1994 ProTherm 14993 6931 155 H62P, T40A, K122R Ribonuclease HI Escherichia coli (strain K12) -0.85 yes Sodium acetate 20 mM 52.7 NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 2.0, 3.0, 7.0 2RN2 18.57285717555455, 26.803000068664552, 29.957777871025932 in tunnel in pocket 7929430 1994 ProTherm 15047 6931 155 H62P, T40A, K122R Ribonuclease HI Escherichia coli (strain K12) -0.52 yes glycine-HCl 10 mM 50.1 NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 2.0, 3.0, 7.0 2RN2 18.57285717555455, 26.803000068664552, 29.957777871025932 in tunnel in pocket 7929430 1994 ProTherm 4090 2078 155 R41C Ribonuclease HI Escherichia coli (strain K12) 102.0 1.6 yes 54.3 Sodium acetate 20 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 1.0 2RN2 19.741818167946555 7929430 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4103 2078 155 R41C Ribonuclease HI Escherichia coli (strain K12) 106.5 0.4 yes 50.5 glycine-HCl 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 1.0 2RN2 19.741818167946555 7929430 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7427 2078 155 R41C Ribonuclease HI Escherichia coli (strain K12) -0.44 yes Sodium acetate 20 mM 52.7 NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 1.0 2RN2 19.741818167946555 7929430 1994 ProTherm capriotti_S1615_map.csv 7664 2078 155 R41C Ribonuclease HI Escherichia coli (strain K12) -0.12 yes glycine-HCl 10 mM 50.1 NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 1.0 2RN2 19.741818167946555 7929430 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 14787 6934 155 E119V, R41C Ribonuclease HI Escherichia coli (strain K12) 107.2 4.2 yes 56.9 Sodium acetate 20 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 1.0, 3.0 2RN2 19.741818167946555, 22.426666577657063 in pocket 7929430 1994 ProTherm 14791 6934 155 E119V, R41C Ribonuclease HI Escherichia coli (strain K12) 101.3 0.3 yes 50.4 glycine-HCl 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 1.0, 3.0 2RN2 19.741818167946555, 22.426666577657063 in pocket 7929430 1994 ProTherm 14995 6934 155 E119V, R41C Ribonuclease HI Escherichia coli (strain K12) -1.2 yes Sodium acetate 20 mM 52.7 NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 1.0, 3.0 2RN2 19.741818167946555, 22.426666577657063 in pocket 7929430 1994 ProTherm 15050 6934 155 E119V, R41C Ribonuclease HI Escherichia coli (strain K12) -0.09 yes glycine-HCl 10 mM 50.1 NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 1.0, 3.0 2RN2 19.741818167946555, 22.426666577657063 in pocket 7929430 1994 ProTherm 764 471 155 E48Q Ribonuclease HI Escherichia coli (strain K12) 1.0 yes 48.0 glycine-NaOH 50 mM CD Thermal 9.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.88111114501953 in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 777 471 155 E48Q Ribonuclease HI Escherichia coli (strain K12) 99.1 -0.2 yes 49.8 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.88111114501953 in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S499.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7681 471 155 E48Q Ribonuclease HI Escherichia coli (strain K12) 0.1 yes glycine-HCl 10 mM 50.0 CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.88111114501953 in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 7803 471 155 E48Q Ribonuclease HI Escherichia coli (strain K12) -0.3 yes glycine-NaOH 50 mM 47.0 CD Thermal 9.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.88111114501953 in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm capriotti_S1615_map.csv 765 472 155 E48A Ribonuclease HI Escherichia coli (strain K12) -1.0 yes 46.0 glycine-NaOH 50 mM CD Thermal 9.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.88111114501953 in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 778 472 155 E48A Ribonuclease HI Escherichia coli (strain K12) 91.6 -0.2 yes 49.8 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.88111114501953 in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7682 472 155 E48A Ribonuclease HI Escherichia coli (strain K12) 0.1 yes glycine-HCl 10 mM 50.0 CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.88111114501953 in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 7804 472 155 E48A Ribonuclease HI Escherichia coli (strain K12) 0.3 yes glycine-NaOH 50 mM 47.0 CD Thermal 9.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.88111114501953 in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 766 473 155 E48D Ribonuclease HI Escherichia coli (strain K12) -0.8 yes 46.2 glycine-NaOH 50 mM CD Thermal 9.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.88111114501953 in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm potapov_with_uniprot_mapping.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 779 473 155 E48D Ribonuclease HI Escherichia coli (strain K12) 103.1 0.8 yes 50.8 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.88111114501953 in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm potapov_with_uniprot_mapping.csv, AUTOMUTE_S1749.csv, AUTOMUTE_S1925.csv, EASE-MM_S1676.csv, I_Mutant2.0_S1948.csv, I_Mutant2.0_S2087.csv, iPTREE-STAB_S1859.csv, M47andM8_S2760.csv, PON-TStab_dataset.csv, Saraboji_S1396.csv, Saraboji_S1791.csv, STRUM_Q3421.csv, SVM-WIN31_SVM-3D12_S499.csv 7683 473 155 E48D Ribonuclease HI Escherichia coli (strain K12) -0.2 yes glycine-HCl 10 mM 50.0 CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.88111114501953 in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 7805 473 155 E48D Ribonuclease HI Escherichia coli (strain K12) 0.2 yes glycine-NaOH 50 mM 47.0 CD Thermal 9.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.88111114501953 in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 602 341 155 A52I Ribonuclease HI Escherichia coli (strain K12) 84.8 6.2 yes 59.2 glycine-HCl 10 mM CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 9.926000022888184 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7396 341 155 A52I Ribonuclease HI Escherichia coli (strain K12) -1.9 yes glycine-HCl 10 mM 53.0 CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 9.926000022888184 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 603 342 155 A52V Ribonuclease HI Escherichia coli (strain K12) 128.0 5.5 yes 58.5 glycine-HCl 10 mM CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 9.926000022888184 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4082 342 155 A52V Ribonuclease HI Escherichia coli (strain K12) 87.5 7.8 yes 60.5 Sodium acetate 20 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 9.926000022888184 in pocket 7929430 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4095 342 155 A52V Ribonuclease HI Escherichia coli (strain K12) 128.0 5.5 yes 55.6 glycine-HCl 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 9.926000022888184 in pocket 7929430 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7397 342 155 A52V Ribonuclease HI Escherichia coli (strain K12) -1.7 yes glycine-HCl 10 mM 53.0 CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 9.926000022888184 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm capriotti_S1615_map.csv, HotMuSiC_S1626.csv, potapov_with_uniprot_mapping.csv 7656 342 155 A52V Ribonuclease HI Escherichia coli (strain K12) -1.7 yes glycine-HCl 10 mM 50.1 NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 9.926000022888184 in pocket 7929430 1994 ProTherm capriotti_S1615_map.csv, HotMuSiC_S1626.csv, potapov_with_uniprot_mapping.csv 604 343 155 A52L Ribonuclease HI Escherichia coli (strain K12) 102.2 4.3 yes 57.3 glycine-HCl 10 mM CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 9.926000022888184 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7398 343 155 A52L Ribonuclease HI Escherichia coli (strain K12) -1.3 yes glycine-HCl 10 mM 53.0 CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 9.926000022888184 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 605 344 155 A52C Ribonuclease HI Escherichia coli (strain K12) 128.3 2.5 yes 55.5 glycine-HCl 10 mM CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 9.926000022888184 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7399 344 155 A52C Ribonuclease HI Escherichia coli (strain K12) -0.8 yes glycine-HCl 10 mM 53.0 CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 9.926000022888184 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 606 345 155 A52M Ribonuclease HI Escherichia coli (strain K12) 111.9 1.6 yes 54.6 glycine-HCl 10 mM CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 9.926000022888184 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm AUTOMUTE_S1749.csv, AUTOMUTE_S1962.csv, Saraboji_S1791.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 7400 345 155 A52M Ribonuclease HI Escherichia coli (strain K12) -0.5 yes glycine-HCl 10 mM 53.0 CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 9.926000022888184 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 607 346 155 A52F Ribonuclease HI Escherichia coli (strain K12) 89.0 -1.5 yes 51.5 glycine-HCl 10 mM CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 9.926000022888184 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7401 346 155 A52F Ribonuclease HI Escherichia coli (strain K12) -0.5 yes glycine-HCl 10 mM 53.0 CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 9.926000022888184 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 608 347 155 A52T Ribonuclease HI Escherichia coli (strain K12) 107.9 -2.7 yes 50.3 glycine-HCl 10 mM CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 9.926000022888184 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7402 347 155 A52T Ribonuclease HI Escherichia coli (strain K12) 0.8 yes glycine-HCl 10 mM 53.0 CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 9.926000022888184 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 609 348 155 A52Q Ribonuclease HI Escherichia coli (strain K12) 90.3 -3.9 yes 49.1 glycine-HCl 10 mM CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 9.926000022888184 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7403 348 155 A52Q Ribonuclease HI Escherichia coli (strain K12) 1.2 yes glycine-HCl 10 mM 53.0 CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 9.926000022888184 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 610 349 155 A52E Ribonuclease HI Escherichia coli (strain K12) 100.6 -5.0 yes 48.0 glycine-HCl 10 mM CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 9.926000022888184 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7404 349 155 A52E Ribonuclease HI Escherichia coli (strain K12) 1.5 yes glycine-HCl 10 mM 53.0 CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 9.926000022888184 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 611 350 155 A52P Ribonuclease HI Escherichia coli (strain K12) 93.0 -5.4 yes 47.6 glycine-HCl 10 mM CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 9.926000022888184 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7405 350 155 A52P Ribonuclease HI Escherichia coli (strain K12) 1.6 yes glycine-HCl 10 mM 53.0 CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 9.926000022888184 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 612 351 155 A52S Ribonuclease HI Escherichia coli (strain K12) 117.6 -5.8 yes 47.2 glycine-HCl 10 mM CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 9.926000022888184 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7406 351 155 A52S Ribonuclease HI Escherichia coli (strain K12) 1.8 yes glycine-HCl 10 mM 53.0 CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 9.926000022888184 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 613 352 155 A52N Ribonuclease HI Escherichia coli (strain K12) 95.6 -5.9 yes 47.1 glycine-HCl 10 mM CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 9.926000022888184 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7407 352 155 A52N Ribonuclease HI Escherichia coli (strain K12) 1.8 yes glycine-HCl 10 mM 53.0 CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 9.926000022888184 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 614 353 155 A52D Ribonuclease HI Escherichia coli (strain K12) 103.5 -6.1 yes 46.9 glycine-HCl 10 mM CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 9.926000022888184 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm AUTOMUTE_S1749.csv, AUTOMUTE_S1962.csv, Saraboji_S1791.csv, Saraboji_S2204.csv, STRUM_Q3421.csv 7408 353 155 A52D Ribonuclease HI Escherichia coli (strain K12) 1.9 yes glycine-HCl 10 mM 53.0 CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 9.926000022888184 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 615 354 155 A52Y Ribonuclease HI Escherichia coli (strain K12) 70.8 -7.6 yes 45.4 glycine-HCl 10 mM CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 9.926000022888184 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7409 354 155 A52Y Ribonuclease HI Escherichia coli (strain K12) 2.3 yes glycine-HCl 10 mM 53.0 CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 9.926000022888184 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 616 355 155 A52G Ribonuclease HI Escherichia coli (strain K12) 91.0 -8.9 yes 44.1 glycine-HCl 10 mM CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 9.926000022888184 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7410 355 155 A52G Ribonuclease HI Escherichia coli (strain K12) 2.7 yes glycine-HCl 10 mM 53.0 CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 9.926000022888184 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 617 356 155 A52H Ribonuclease HI Escherichia coli (strain K12) 84.7 -11.8 yes 41.2 glycine-HCl 10 mM CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 9.926000022888184 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7411 356 155 A52H Ribonuclease HI Escherichia coli (strain K12) 3.6 yes glycine-HCl 10 mM 53.0 CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 9.926000022888184 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 618 357 155 A52K Ribonuclease HI Escherichia coli (strain K12) 70.8 -19.5 yes 33.5 glycine-HCl 10 mM CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 9.926000022888184 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7412 357 155 A52K Ribonuclease HI Escherichia coli (strain K12) 5.9 yes glycine-HCl 10 mM 53.0 CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 9.926000022888184 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14525 6753 155 A52V, V74A Ribonuclease HI Escherichia coli (strain K12) 106.9 -1.7 yes 51.3 glycine-HCl 10 mM CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0, 8.0 2RN2 9.926000022888184, 13.321428571428571 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm 14984 6753 155 A52V, V74A Ribonuclease HI Escherichia coli (strain K12) 0.52 yes glycine-HCl 10 mM 53.0 CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0, 8.0 2RN2 9.926000022888184, 13.321428571428571 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm 14526 6754 155 A52L, V74A Ribonuclease HI Escherichia coli (strain K12) 105.2 1.2 yes 54.2 glycine-HCl 10 mM CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0, 8.0 2RN2 9.926000022888184, 13.321428571428571 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm 14985 6754 155 A52L, V74A Ribonuclease HI Escherichia coli (strain K12) -0.36 yes glycine-HCl 10 mM 53.0 CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0, 8.0 2RN2 9.926000022888184, 13.321428571428571 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm 14527 6755 155 A52I, V74A Ribonuclease HI Escherichia coli (strain K12) 101.9 3.9 yes 56.9 glycine-HCl 10 mM CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0, 8.0 2RN2 9.926000022888184, 13.321428571428571 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm 14986 6755 155 A52I, V74A Ribonuclease HI Escherichia coli (strain K12) -1.19 yes glycine-HCl 10 mM 53.0 CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0, 8.0 2RN2 9.926000022888184, 13.321428571428571 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm 14528 6756 155 A52F, V74A Ribonuclease HI Escherichia coli (strain K12) 85.8 -4.6 yes 48.4 glycine-HCl 10 mM CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0, 8.0 2RN2 9.926000022888184, 13.321428571428571 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm 14987 6756 155 A52F, V74A Ribonuclease HI Escherichia coli (strain K12) 1.4 yes glycine-HCl 10 mM 53.0 CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0, 8.0 2RN2 9.926000022888184, 13.321428571428571 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm 14529 6757 155 A52G, V74L Ribonuclease HI Escherichia coli (strain K12) 97.8 -4.6 yes 48.4 glycine-HCl 10 mM CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0, 8.0 2RN2 9.926000022888184, 13.321428571428571 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm 14988 6757 155 A52G, V74L Ribonuclease HI Escherichia coli (strain K12) 1.4 yes glycine-HCl 10 mM 53.0 CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0, 8.0 2RN2 9.926000022888184, 13.321428571428571 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm 14530 6758 155 A52V, V74L Ribonuclease HI Escherichia coli (strain K12) 125.5 8.07 yes 61.0 glycine-HCl 10 mM CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0, 8.0 2RN2 9.926000022888184, 13.321428571428571 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm 14989 6758 155 A52V, V74L Ribonuclease HI Escherichia coli (strain K12) -2.43 yes glycine-HCl 10 mM 53.0 CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0, 8.0 2RN2 9.926000022888184, 13.321428571428571 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm 14531 6759 155 A52L, V74L Ribonuclease HI Escherichia coli (strain K12) 118.1 4.9 yes 57.9 glycine-HCl 10 mM CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0, 8.0 2RN2 9.926000022888184, 13.321428571428571 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm 14990 6759 155 A52L, V74L Ribonuclease HI Escherichia coli (strain K12) -1.49 yes glycine-HCl 10 mM 53.0 CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0, 8.0 2RN2 9.926000022888184, 13.321428571428571 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm 14532 6760 155 A52I, V74L Ribonuclease HI Escherichia coli (strain K12) 122.3 3.9 yes 56.9 glycine-HCl 10 mM CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0, 8.0 2RN2 9.926000022888184, 13.321428571428571 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm 14991 6760 155 A52I, V74L Ribonuclease HI Escherichia coli (strain K12) -1.19 yes glycine-HCl 10 mM 53.0 CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0, 8.0 2RN2 9.926000022888184, 13.321428571428571 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm 14533 6761 155 A52F, V74L Ribonuclease HI Escherichia coli (strain K12) 99.8 0.1 yes 53.1 glycine-HCl 10 mM CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0, 8.0 2RN2 9.926000022888184, 13.321428571428571 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm 14992 6761 155 A52F, V74L Ribonuclease HI Escherichia coli (strain K12) -0.03 yes glycine-HCl 10 mM 53.0 CD Thermal 3.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0, 8.0 2RN2 9.926000022888184, 13.321428571428571 in pocket 9228039 10.1074/jbc.272.30.18686 1997 ProTherm 3960 2041 155 I53A Ribonuclease HI Escherichia coli (strain K12) -12.1 yes 35.7 Potassium phosphate 2 mM KF 5 mM CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 10.25000011920929 10467093 10.1038/12277 1999 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 11060 2041 155 I53A Ribonuclease HI Escherichia coli (strain K12) 2.1 7.6 2.1 yes Potassium phosphate 2 mM 25.0 KF 5 mM CD Urea 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 10.25000011920929 10467093 10.1038/12277 1999 ProTherm SAAFEC_S1262.csv 9118 3941 155 I53V Ribonuclease HI Escherichia coli (strain K12) 0.2 9.5 2.1 Unknown sodium acetate 20 mM 25.0 KCl 50 mM CD Urea 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 10.25000011920929 14672667 10.1016/j.jmb.2003.10.052 2004 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 9119 3942 155 I53L Ribonuclease HI Escherichia coli (strain K12) 1.4 8.3 2.3 Unknown sodium acetate 20 mM 25.0 KCl 50 mM CD Urea 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 10.25000011920929 14672667 10.1016/j.jmb.2003.10.052 2004 ProTherm SAAFEC_S1262.csv 9120 3943 155 I53F Ribonuclease HI Escherichia coli (strain K12) 3.9 5.8 2.0 Unknown sodium acetate 20 mM 25.0 KCl 50 mM CD Urea 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 10.25000011920929 14672667 10.1016/j.jmb.2003.10.052 2004 ProTherm SAAFEC_S1262.csv 9121 3944 155 I53D Ribonuclease HI Escherichia coli (strain K12) 4.1 5.6 2.0 Unknown sodium acetate 20 mM 25.0 KCl 50 mM CD Urea 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 10.25000011920929 14672667 10.1016/j.jmb.2003.10.052 2004 ProTherm 9122 3944 155 I53D Ribonuclease HI Escherichia coli (strain K12) 2.1 7.6 2.0 Unknown sodium acetate 20 mM 25.0 KCl 50 mM CD Urea 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 10.25000011920929 14672667 10.1016/j.jmb.2003.10.052 2004 ProTherm 14786 6933 155 E119V, K60R Ribonuclease HI Escherichia coli (strain K12) 98.6 2.3 yes 55.0 Sodium acetate 20 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0, 3.0 2RN2 30.117778142293293, 22.426666577657063 in pocket 7929430 1994 ProTherm 14790 6933 155 E119V, K60R Ribonuclease HI Escherichia coli (strain K12) 108.7 -0.2 yes 49.9 glycine-HCl 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0, 3.0 2RN2 30.117778142293293, 22.426666577657063 in pocket 7929430 1994 ProTherm 14994 6933 155 E119V, K60R Ribonuclease HI Escherichia coli (strain K12) -0.63 yes Sodium acetate 20 mM 52.7 NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0, 3.0 2RN2 30.117778142293293, 22.426666577657063 in pocket 7929430 1994 ProTherm 15049 6933 155 E119V, K60R Ribonuclease HI Escherichia coli (strain K12) 0.06 yes glycine-HCl 10 mM 50.1 NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0, 3.0 2RN2 30.117778142293293, 22.426666577657063 in pocket 7929430 1994 ProTherm 2885 1524 155 H62P Ribonuclease HI Escherichia coli (strain K12) 109.5 3.4 yes 53.2 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 26.803000068664552 in pocket 1328237 1992 ProTherm STRUM_Q306.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 2887 1524 155 H62P Ribonuclease HI Escherichia coli (strain K12) 102.0 4.1 yes 56.1 Sodium acetate 20 mM CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 26.803000068664552 in pocket 1328237 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3925 1524 155 H62P Ribonuclease HI Escherichia coli (strain K12) 109.5 3.4 yes 54.3 glycine-HCl 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 26.803000068664552 in pocket 7794925 10.1021/bi00025a018 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3929 1524 155 H62P Ribonuclease HI Escherichia coli (strain K12) 102.0 4.1 yes 56.6 Sodium acetate 10 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 26.803000068664552 in pocket 7794925 10.1021/bi00025a018 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4084 1524 155 H62P Ribonuclease HI Escherichia coli (strain K12) 102.0 4.1 yes 56.8 Sodium acetate 20 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 26.803000068664552 in pocket 7929430 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4097 1524 155 H62P Ribonuclease HI Escherichia coli (strain K12) 109.5 3.4 yes 53.5 glycine-HCl 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 26.803000068664552 in pocket 7929430 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7423 1524 155 H62P Ribonuclease HI Escherichia coli (strain K12) -1.1 yes Sodium acetate 20 mM 52.7 NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 26.803000068664552 in pocket 7929430 1994 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 7456 1524 155 H62P Ribonuclease HI Escherichia coli (strain K12) -1.1 yes Sodium acetate 10 mM 52.5 NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 26.803000068664552 in pocket 7794925 10.1021/bi00025a018 1995 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 7464 1524 155 H62P Ribonuclease HI Escherichia coli (strain K12) -1.1 yes Sodium acetate 20 mM 52.0 CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 26.803000068664552 in pocket 1328237 1992 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 7620 1524 155 H62P Ribonuclease HI Escherichia coli (strain K12) -1.0 yes glycine-HCl 10 mM 50.9 NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 26.803000068664552 in pocket 7794925 10.1021/bi00025a018 1995 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 7658 1524 155 H62P Ribonuclease HI Escherichia coli (strain K12) -1.0 yes glycine-HCl 10 mM 50.1 NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 26.803000068664552 in pocket 7929430 1994 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 7732 1524 155 H62P Ribonuclease HI Escherichia coli (strain K12) -1.0 yes glycine-HCl 10 mM 49.8 CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 26.803000068664552 in pocket 1328237 1992 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 10454 1524 155 H62P Ribonuclease HI Escherichia coli (strain K12) 1.98 -0.74 9.89 4.98 yes Sodium acetate 20 mM 25.0 CD GdnHCl 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 26.803000068664552 in pocket 1328237 1992 ProTherm SAAFEC_S1262.csv 3964 2044 155 H62A Ribonuclease HI Escherichia coli (strain K12) 1.3 yes 50.7 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 26.803000068664552 in pocket 7764048 10.1016/0168-1656(93)90129-b 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3971 2044 155 H62A Ribonuclease HI Escherichia coli (strain K12) 1.0 yes 51.2 Sodium phosphate 20 mM CD Thermal 7.8 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 26.803000068664552 in pocket 7764048 10.1016/0168-1656(93)90129-b 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 10727 2044 155 H62A Ribonuclease HI Escherichia coli (strain K12) 1.86 -0.38 9.64 5.19 yes Sodium acetate 20 mM 25.0 NaCl 0.1 M Fluorescence GdnHCl 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 26.803000068664552 in pocket 1645658 10.1111/j.1432-1033.1991.tb16033.x 1991 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 11064 2044 155 H62A Ribonuclease HI Escherichia coli (strain K12) 1.86 -0.36 9.57 yes Sodium acetate 20 mM 25.0 CD GdnHCl 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 26.803000068664552 in pocket 7764048 10.1016/0168-1656(93)90129-b 1993 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 11068 2044 155 H62A Ribonuclease HI Escherichia coli (strain K12) 1.76 -0.58 9.07 yes Tris-HCl 20 mM 25.0 CD GdnHCl 8.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 26.803000068664552 in pocket 7764048 10.1016/0168-1656(93)90129-b 1993 ProTherm 4083 2072 155 H62R Ribonuclease HI Escherichia coli (strain K12) 97.1 1.3 yes 54.0 Sodium acetate 20 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 26.803000068664552 in pocket 7929430 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4096 2072 155 H62R Ribonuclease HI Escherichia coli (strain K12) 114.5 -0.1 yes 50.0 glycine-HCl 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 26.803000068664552 in pocket 7929430 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7422 2072 155 H62R Ribonuclease HI Escherichia coli (strain K12) -0.36 yes Sodium acetate 20 mM 52.7 NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 26.803000068664552 in pocket 7929430 1994 ProTherm capriotti_S1615_map.csv 7657 2072 155 H62R Ribonuclease HI Escherichia coli (strain K12) 0.03 yes glycine-HCl 10 mM 50.1 NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 26.803000068664552 in pocket 7929430 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 4085 2073 155 H62D Ribonuclease HI Escherichia coli (strain K12) 97.8 -0.6 yes 52.1 Sodium acetate 20 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 26.803000068664552 in pocket 7929430 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4098 2073 155 H62D Ribonuclease HI Escherichia coli (strain K12) 118.4 2.2 yes 52.3 glycine-HCl 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 26.803000068664552 in pocket 7929430 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7424 2073 155 H62D Ribonuclease HI Escherichia coli (strain K12) 0.17 yes Sodium acetate 20 mM 52.7 NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 26.803000068664552 in pocket 7929430 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 7659 2073 155 H62D Ribonuclease HI Escherichia coli (strain K12) -0.67 yes glycine-HCl 10 mM 50.1 NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 26.803000068664552 in pocket 7929430 1994 ProTherm capriotti_S1615_map.csv 14777 6928 155 H62A, H83A Ribonuclease HI Escherichia coli (strain K12) 3.6 yes 53.0 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0, 1.0 2RN2 26.803000068664552, 30.325999450683593 in pocket 7764048 10.1016/0168-1656(93)90129-b 1993 ProTherm 14781 6928 155 H62A, H83A Ribonuclease HI Escherichia coli (strain K12) 1.3 yes 51.5 Sodium phosphate 20 mM CD Thermal 7.8 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0, 1.0 2RN2 26.803000068664552, 30.325999450683593 in pocket 7764048 10.1016/0168-1656(93)90129-b 1993 ProTherm 14779 6930 155 H62A, H83A, H124A, H127A Ribonuclease HI Escherichia coli (strain K12) 5.5 yes 54.9 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0, 1.0, 9.0, 7.0 2RN2 26.803000068664552, 30.325999450683593, 25.72599983215332, 29.089000129699706 in tunnel in pocket 7764048 10.1016/0168-1656(93)90129-b 1993 ProTherm 14783 6930 155 H62A, H83A, H124A, H127A Ribonuclease HI Escherichia coli (strain K12) 1.5 yes 51.7 Sodium phosphate 20 mM CD Thermal 7.8 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0, 1.0, 9.0, 7.0 2RN2 26.803000068664552, 30.325999450683593, 25.72599983215332, 29.089000129699706 in tunnel in pocket 7764048 10.1016/0168-1656(93)90129-b 1993 ProTherm 3446 1793 155 S68G Ribonuclease HI Escherichia coli (strain K12) 84.7 -8.0 yes 41.8 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 4.0 2RN2 13.96500015258789 in pocket 1317795 10.1111/j.1432-1033.1992.tb16932.x 1992 ProTherm AUTOMUTE_S1962.csv, Broom_S605.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7726 1793 155 S68G Ribonuclease HI Escherichia coli (strain K12) 2.4 yes glycine-HCl 10 mM 49.8 CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 4.0 2RN2 13.96500015258789 in pocket 1317795 10.1111/j.1432-1033.1992.tb16932.x 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 10736 1793 155 S68G Ribonuclease HI Escherichia coli (strain K12) 4.0 2.2 7.61 2.0 yes Sodium acetate 10 mM 25.0 NaCl 0.1 M CD Urea 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 4.0 2RN2 13.96500015258789 in pocket 1317795 10.1111/j.1432-1033.1992.tb16932.x 1992 ProTherm SAAFEC_S1262.csv 3447 1794 155 S68A Ribonuclease HI Escherichia coli (strain K12) 89.0 -1.5 yes 48.3 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 4.0 2RN2 13.96500015258789 in pocket 1317795 10.1111/j.1432-1033.1992.tb16932.x 1992 ProTherm AUTOMUTE_S1962.csv, Broom_S605.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7727 1794 155 S68A Ribonuclease HI Escherichia coli (strain K12) 0.5 yes glycine-HCl 10 mM 49.8 CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 4.0 2RN2 13.96500015258789 in pocket 1317795 10.1111/j.1432-1033.1992.tb16932.x 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 10737 1794 155 S68A Ribonuclease HI Escherichia coli (strain K12) 4.8 -0.19 10.0 2.06 yes Sodium acetate 10 mM 25.0 NaCl 0.1 M CD Urea 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 4.0 2RN2 13.96500015258789 in pocket 1317795 10.1111/j.1432-1033.1992.tb16932.x 1992 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 3448 1795 155 S68T Ribonuclease HI Escherichia coli (strain K12) 106.2 -0.7 yes 49.1 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 4.0 2RN2 13.96500015258789 in pocket 1317795 10.1111/j.1432-1033.1992.tb16932.x 1992 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Broom_S605.csv, Saraboji_S1791.csv 7728 1795 155 S68T Ribonuclease HI Escherichia coli (strain K12) 0.2 yes glycine-HCl 10 mM 49.8 CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 4.0 2RN2 13.96500015258789 in pocket 1317795 10.1111/j.1432-1033.1992.tb16932.x 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 10738 1795 155 S68T Ribonuclease HI Escherichia coli (strain K12) 5.0 -0.1 9.91 1.95 yes Sodium acetate 10 mM 25.0 NaCl 0.1 M CD Urea 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 4.0 2RN2 13.96500015258789 in pocket 1317795 10.1111/j.1432-1033.1992.tb16932.x 1992 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 3449 1796 155 S68V Ribonuclease HI Escherichia coli (strain K12) 98.8 1.9 yes 51.7 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 4.0 2RN2 13.96500015258789 in pocket 1317795 10.1111/j.1432-1033.1992.tb16932.x 1992 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, Broom_S605.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7729 1796 155 S68V Ribonuclease HI Escherichia coli (strain K12) -0.6 yes glycine-HCl 10 mM 49.8 CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 4.0 2RN2 13.96500015258789 in pocket 1317795 10.1111/j.1432-1033.1992.tb16932.x 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 10739 1796 155 S68V Ribonuclease HI Escherichia coli (strain K12) 5.1 -1.29 11.1 2.13 yes Sodium acetate 10 mM 25.0 NaCl 0.1 M CD Urea 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 4.0 2RN2 13.96500015258789 in pocket 1317795 10.1111/j.1432-1033.1992.tb16932.x 1992 ProTherm SAAFEC_S1262.csv 3450 1797 155 S68L Ribonuclease HI Escherichia coli (strain K12) 84.0 -1.6 yes 48.2 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 4.0 2RN2 13.96500015258789 in pocket 1317795 10.1111/j.1432-1033.1992.tb16932.x 1992 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Broom_S605.csv, Saraboji_S1791.csv 7730 1797 155 S68L Ribonuclease HI Escherichia coli (strain K12) 0.5 yes glycine-HCl 10 mM 49.8 CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 4.0 2RN2 13.96500015258789 in pocket 1317795 10.1111/j.1432-1033.1992.tb16932.x 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 10740 1797 155 S68L Ribonuclease HI Escherichia coli (strain K12) 4.6 1.0 8.81 1.89 yes Sodium acetate 10 mM 25.0 NaCl 0.1 M CD Urea 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 4.0 2RN2 13.96500015258789 in pocket 1317795 10.1111/j.1432-1033.1992.tb16932.x 1992 ProTherm SAAFEC_S1262.csv 767 474 155 D70N Ribonuclease HI Escherichia coli (strain K12) 5.5 yes 52.5 glycine-NaOH 50 mM CD Thermal 9.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 18.195000410079956 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 780 474 155 D70N Ribonuclease HI Escherichia coli (strain K12) 110.1 -1.2 yes 48.8 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 18.195000410079956 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7684 474 155 D70N Ribonuclease HI Escherichia coli (strain K12) 0.3 yes glycine-HCl 10 mM 50.0 CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 18.195000410079956 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 7806 474 155 D70N Ribonuclease HI Escherichia coli (strain K12) -1.6 yes glycine-NaOH 50 mM 47.0 CD Thermal 9.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 18.195000410079956 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm capriotti_S1615_map.csv 768 475 155 D70A Ribonuclease HI Escherichia coli (strain K12) 3.8 yes 50.8 glycine-NaOH 50 mM CD Thermal 9.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 18.195000410079956 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 781 475 155 D70A Ribonuclease HI Escherichia coli (strain K12) 85.5 -0.3 yes 49.7 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 18.195000410079956 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7685 475 155 D70A Ribonuclease HI Escherichia coli (strain K12) 0.1 yes glycine-HCl 10 mM 50.0 CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 18.195000410079956 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 7807 475 155 D70A Ribonuclease HI Escherichia coli (strain K12) -1.1 yes glycine-NaOH 50 mM 47.0 CD Thermal 9.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 18.195000410079956 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm capriotti_S1615_map.csv 769 476 155 D70E Ribonuclease HI Escherichia coli (strain K12) 0.4 yes 47.4 glycine-NaOH 50 mM CD Thermal 9.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 18.195000410079956 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 782 476 155 D70E Ribonuclease HI Escherichia coli (strain K12) 90.4 1.8 yes 51.8 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 18.195000410079956 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7686 476 155 D70E Ribonuclease HI Escherichia coli (strain K12) -0.5 yes glycine-HCl 10 mM 50.0 CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 18.195000410079956 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm capriotti_S1615_map.csv 7808 476 155 D70E Ribonuclease HI Escherichia coli (strain K12) -0.1 yes glycine-NaOH 50 mM 47.0 CD Thermal 9.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 18.195000410079956 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 3926 2026 155 V74L Ribonuclease HI Escherichia coli (strain K12) 118.6 3.7 yes 54.6 glycine-HCl 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 13.321428571428571 in pocket 7794925 10.1021/bi00025a018 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3930 2026 155 V74L Ribonuclease HI Escherichia coli (strain K12) 91.2 3.3 yes 55.8 Sodium acetate 10 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 13.321428571428571 in pocket 7794925 10.1021/bi00025a018 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4074 2026 155 V74L Ribonuclease HI Escherichia coli (strain K12) 3.7 yes 53.5 glycine-HCl 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 13.321428571428571 in pocket 3191114 10.1021/bi00416a052 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4077 2026 155 V74L Ribonuclease HI Escherichia coli (strain K12) 3.3 yes 55.3 Sodium acetate 20 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 13.321428571428571 in pocket 3191114 10.1021/bi00416a052 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4663 2026 155 V74L Ribonuclease HI Escherichia coli (strain K12) -1.1 3.7 yes Gly-HCl buffer 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 13.321428571428571 in pocket 8390295 1993 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4666 2026 155 V74L Ribonuclease HI Escherichia coli (strain K12) -0.9 3.3 yes sodium acetate 20 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 13.321428571428571 in pocket 8390295 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7457 2026 155 V74L Ribonuclease HI Escherichia coli (strain K12) -0.9 yes Sodium acetate 10 mM 52.5 NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 13.321428571428571 in pocket 7794925 10.1021/bi00025a018 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 7467 2026 155 V74L Ribonuclease HI Escherichia coli (strain K12) -0.9 yes Sodium acetate 20 mM 52.0 NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 13.321428571428571 in pocket 3191114 10.1021/bi00416a052 1988 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 7621 2026 155 V74L Ribonuclease HI Escherichia coli (strain K12) -1.1 yes glycine-HCl 10 mM 50.9 NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 13.321428571428571 in pocket 7794925 10.1021/bi00025a018 1995 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 7735 2026 155 V74L Ribonuclease HI Escherichia coli (strain K12) -1.1 yes glycine-HCl 10 mM 49.8 NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 13.321428571428571 in pocket 3191114 10.1021/bi00416a052 1988 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 4075 2069 155 V74I Ribonuclease HI Escherichia coli (strain K12) 2.4 yes 52.2 glycine-HCl 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 13.321428571428571 in pocket 3191114 10.1021/bi00416a052 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4078 2069 155 V74I Ribonuclease HI Escherichia coli (strain K12) 2.1 yes 54.1 Sodium acetate 20 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 13.321428571428571 in pocket 3191114 10.1021/bi00416a052 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4664 2069 155 V74I Ribonuclease HI Escherichia coli (strain K12) -0.7 2.4 yes Gly-HCl buffer 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 13.321428571428571 in pocket 8390295 1993 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4667 2069 155 V74I Ribonuclease HI Escherichia coli (strain K12) -0.6 2.1 yes sodium acetate 20 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 13.321428571428571 in pocket 8390295 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7468 2069 155 V74I Ribonuclease HI Escherichia coli (strain K12) -0.6 yes Sodium acetate 20 mM 52.0 NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 13.321428571428571 in pocket 3191114 10.1021/bi00416a052 1988 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 7736 2069 155 V74I Ribonuclease HI Escherichia coli (strain K12) -0.7 yes glycine-HCl 10 mM 49.8 NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 13.321428571428571 in pocket 3191114 10.1021/bi00416a052 1988 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 4076 2070 155 V74A Ribonuclease HI Escherichia coli (strain K12) -7.6 yes 42.2 glycine-HCl 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 13.321428571428571 in pocket 3191114 10.1021/bi00416a052 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4079 2070 155 V74A Ribonuclease HI Escherichia coli (strain K12) -12.7 yes 39.3 Sodium acetate 20 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 13.321428571428571 in pocket 3191114 10.1021/bi00416a052 1988 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4665 2070 155 V74A Ribonuclease HI Escherichia coli (strain K12) 2.2 -7.6 yes Gly-HCl buffer 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 13.321428571428571 in pocket 8390295 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4668 2070 155 V74A Ribonuclease HI Escherichia coli (strain K12) 3.4 -12.7 yes sodium acetate 20 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 13.321428571428571 in pocket 8390295 1993 ProTherm capriotti_S1615_map.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7469 2070 155 V74A Ribonuclease HI Escherichia coli (strain K12) 3.4 yes Sodium acetate 20 mM 52.0 NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 13.321428571428571 in pocket 3191114 10.1021/bi00416a052 1988 ProTherm capriotti_S1615_map.csv 7737 2070 155 V74A Ribonuclease HI Escherichia coli (strain K12) 2.2 yes glycine-HCl 10 mM 49.8 NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 13.321428571428571 in pocket 3191114 10.1021/bi00416a052 1988 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 4086 2074 155 Q76L Ribonuclease HI Escherichia coli (strain K12) 81.2 1.1 yes 53.8 Sodium acetate 20 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0 2RN2 18.828888787163628 7929430 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4099 2074 155 Q76L Ribonuclease HI Escherichia coli (strain K12) 110.3 0.8 yes 50.9 glycine-HCl 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0 2RN2 18.828888787163628 7929430 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7660 2074 155 Q76L Ribonuclease HI Escherichia coli (strain K12) -0.24 yes glycine-HCl 10 mM 50.1 NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0 2RN2 18.828888787163628 7929430 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 4054 2065 155 G77A Ribonuclease HI Escherichia coli (strain K12) -2.9 yes 46.9 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 17.544999837875366 8393706 10.1021/bi00079a010 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7731 2065 155 G77A Ribonuclease HI Escherichia coli (strain K12) 0.9 yes glycine-HCl 10 mM 49.8 CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 17.544999837875366 8393706 10.1021/bi00079a010 1993 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 4087 2075 155 Q80L Ribonuclease HI Escherichia coli (strain K12) 94.6 0.8 yes 53.5 Sodium acetate 20 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 4.0 2RN2 22.50444433424208 7929430 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4100 2075 155 Q80L Ribonuclease HI Escherichia coli (strain K12) 114.5 1.0 yes 51.1 glycine-HCl 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 4.0 2RN2 22.50444433424208 7929430 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7661 2075 155 Q80L Ribonuclease HI Escherichia coli (strain K12) -0.3 yes glycine-HCl 10 mM 50.1 NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 4.0 2RN2 22.50444433424208 7929430 1994 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 14785 6932 155 Q80L, K117R Ribonuclease HI Escherichia coli (strain K12) 83.1 0.8 yes 53.5 Sodium acetate 20 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 4.0, 1.0 2RN2 22.50444433424208, 23.851110882229275 in pocket 7929430 1994 ProTherm 14789 6932 155 Q80L, K117R Ribonuclease HI Escherichia coli (strain K12) 103.6 -0.1 yes 50.0 glycine-HCl 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 4.0, 1.0 2RN2 22.50444433424208, 23.851110882229275 in pocket 7929430 1994 ProTherm 15048 6932 155 Q80L, K117R Ribonuclease HI Escherichia coli (strain K12) 0.03 yes glycine-HCl 10 mM 50.1 NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 4.0, 1.0 2RN2 22.50444433424208, 23.851110882229275 in pocket 7929430 1994 ProTherm 3965 2045 155 H83A Ribonuclease HI Escherichia coli (strain K12) 2.1 yes 51.5 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 1.0 2RN2 30.325999450683593 in pocket 7764048 10.1016/0168-1656(93)90129-b 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3969 2045 155 H83A Ribonuclease HI Escherichia coli (strain K12) 0.1 yes 52.8 Sodium acetate 20 mM CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 1.0 2RN2 30.325999450683593 in pocket 7764048 10.1016/0168-1656(93)90129-b 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3972 2045 155 H83A Ribonuclease HI Escherichia coli (strain K12) -0.2 yes 50.0 Sodium phosphate 20 mM CD Thermal 7.8 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 1.0 2RN2 30.325999450683593 in pocket 7764048 10.1016/0168-1656(93)90129-b 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 10728 2045 155 H83A Ribonuclease HI Escherichia coli (strain K12) 1.83 0.01 9.25 5.05 yes Sodium acetate 20 mM 25.0 NaCl 0.1 M Fluorescence GdnHCl 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 1.0 2RN2 30.325999450683593 in pocket 1645658 10.1111/j.1432-1033.1991.tb16033.x 1991 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 11065 2045 155 H83A Ribonuclease HI Escherichia coli (strain K12) 1.83 -0.22 9.43 yes Sodium acetate 20 mM 25.0 CD GdnHCl 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 1.0 2RN2 30.325999450683593 in pocket 7764048 10.1016/0168-1656(93)90129-b 1993 ProTherm 11069 2045 155 H83A Ribonuclease HI Escherichia coli (strain K12) 1.63 0.09 8.4 yes Tris-HCl 20 mM 25.0 CD GdnHCl 8.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 1.0 2RN2 30.325999450683593 in pocket 7764048 10.1016/0168-1656(93)90129-b 1993 ProTherm 3760 1948 155 K91R Ribonuclease HI Escherichia coli (strain K12) 119.1 0.5 yes 49.8 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0 2RN2 17.638889100816513 1331044 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3761 1948 155 K91R Ribonuclease HI Escherichia coli (strain K12) 96.2 0.1 yes 52.0 Sodium acetate 20 mM CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0 2RN2 17.638889100816513 1331044 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7716 1948 155 K91R Ribonuclease HI Escherichia coli (strain K12) -0.2 yes glycine-HCl 10 mM 49.8 CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0 2RN2 17.638889100816513 1331044 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 7717 1948 155 K91R Ribonuclease HI Escherichia coli (strain K12) 0.0 yes Sodium acetate 20 mM 49.8 CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0 2RN2 17.638889100816513 1331044 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14471 6715 155 K91R, D94E Ribonuclease HI Escherichia coli (strain K12) 93.8 -2.0 yes 47.8 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0, 3.0 2RN2 17.638889100816513, 24.66249990463257 1331044 1992 ProTherm 14472 6715 155 K91R, D94E Ribonuclease HI Escherichia coli (strain K12) 87.5 -1.8 yes 50.2 glycine-HCl 10 mM CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0, 3.0 2RN2 17.638889100816513, 24.66249990463257 1331044 1992 ProTherm 15052 6715 155 K91R, D94E Ribonuclease HI Escherichia coli (strain K12) 0.6 yes glycine-HCl 10 mM 49.8 CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0, 3.0 2RN2 17.638889100816513, 24.66249990463257 1331044 1992 ProTherm 15053 6715 155 K91R, D94E Ribonuclease HI Escherichia coli (strain K12) 0.5 yes glycine-HCl 10 mM 49.8 CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0, 3.0 2RN2 17.638889100816513, 24.66249990463257 1331044 1992 ProTherm 14475 6717 155 K91R, K95G Ribonuclease HI Escherichia coli (strain K12) 114.1 5.2 yes 55.0 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0, 5.0 2RN2 17.638889100816513, 21.986666785346138 1331044 1992 ProTherm 14476 6717 155 K91R, K95G Ribonuclease HI Escherichia coli (strain K12) 92.0 5.8 yes 57.8 glycine-HCl 10 mM CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0, 5.0 2RN2 17.638889100816513, 21.986666785346138 1331044 1992 ProTherm 15056 6717 155 K91R, K95G Ribonuclease HI Escherichia coli (strain K12) -1.6 yes glycine-HCl 10 mM 49.8 CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0, 5.0 2RN2 17.638889100816513, 21.986666785346138 1331044 1992 ProTherm 15057 6717 155 K91R, K95G Ribonuclease HI Escherichia coli (strain K12) -1.6 yes glycine-HCl 10 mM 49.8 CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0, 5.0 2RN2 17.638889100816513, 21.986666785346138 1331044 1992 ProTherm 14669 6842 155 K91R, D94E, K95G Ribonuclease HI Escherichia coli (strain K12) 104.8 4.0 yes 53.8 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0, 3.0, 5.0 2RN2 17.638889100816513, 24.66249990463257, 21.986666785346138 1328237 1992 ProTherm 14670 6842 155 K91R, D94E, K95G Ribonuclease HI Escherichia coli (strain K12) 86.8 5.6 yes 57.6 glycine-HCl 10 mM CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0, 3.0, 5.0 2RN2 17.638889100816513, 24.66249990463257, 21.986666785346138 1328237 1992 ProTherm 14998 6842 155 K91R, D94E, K95G Ribonuclease HI Escherichia coli (strain K12) -1.5 yes glycine-HCl 10 mM 52.0 CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0, 3.0, 5.0 2RN2 17.638889100816513, 24.66249990463257, 21.986666785346138 1328237 1992 ProTherm 15059 6842 155 K91R, D94E, K95G Ribonuclease HI Escherichia coli (strain K12) -1.2 yes glycine-HCl 10 mM 49.8 CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0, 3.0, 5.0 2RN2 17.638889100816513, 24.66249990463257, 21.986666785346138 1328237 1992 ProTherm 15293 6842 155 K91R, D94E, K95G Ribonuclease HI Escherichia coli (strain K12) 2.1 0.01 9.14 4.36 yes glycine-HCl 10 mM 25.0 CD GdnHCl 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0, 3.0, 5.0 2RN2 17.638889100816513, 24.66249990463257, 21.986666785346138 1328237 1992 ProTherm 290 156 155 D94E Ribonuclease HI Escherichia coli (strain K12) 92.9 -1.6 yes 52.0 Sodium acetate 20 mM CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 24.66249990463257 1331044 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3762 156 155 D94E Ribonuclease HI Escherichia coli (strain K12) 95.9 -1.2 yes 49.8 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 24.66249990463257 1331044 1992 ProTherm AUTOMUTE_S1962.csv, Saraboji_S2204.csv, Broom_S605.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7718 156 155 D94E Ribonuclease HI Escherichia coli (strain K12) 0.4 yes glycine-HCl 10 mM 49.8 CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 24.66249990463257 1331044 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 7719 156 155 D94E Ribonuclease HI Escherichia coli (strain K12) 0.4 yes Sodium acetate 20 mM 49.8 CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 24.66249990463257 1331044 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 14473 6716 155 D94R, K95G Ribonuclease HI Escherichia coli (strain K12) 126.7 3.6 yes 53.4 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0, 5.0 2RN2 24.66249990463257, 21.986666785346138 1331044 1992 ProTherm 14474 6716 155 D94R, K95G Ribonuclease HI Escherichia coli (strain K12) 102.4 5.5 yes 57.5 glycine-HCl 10 mM CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0, 5.0 2RN2 24.66249990463257, 21.986666785346138 1331044 1992 ProTherm 15054 6716 155 D94R, K95G Ribonuclease HI Escherichia coli (strain K12) -1.1 yes glycine-HCl 10 mM 49.8 CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0, 5.0 2RN2 24.66249990463257, 21.986666785346138 1331044 1992 ProTherm 15055 6716 155 D94R, K95G Ribonuclease HI Escherichia coli (strain K12) -1.5 yes glycine-HCl 10 mM 49.8 CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0, 5.0 2RN2 24.66249990463257, 21.986666785346138 1331044 1992 ProTherm 291 157 155 K95G Ribonuclease HI Escherichia coli (strain K12) 102.4 5.7 yes 49.8 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0 2RN2 21.986666785346138 1331044 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 292 157 155 K95G Ribonuclease HI Escherichia coli (strain K12) 90.4 6.8 yes 52.0 Sodium acetate 20 mM CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0 2RN2 21.986666785346138 1331044 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7720 157 155 K95G Ribonuclease HI Escherichia coli (strain K12) -1.7 yes glycine-HCl 10 mM 49.8 CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0 2RN2 21.986666785346138 1331044 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 7721 157 155 K95G Ribonuclease HI Escherichia coli (strain K12) -1.9 yes Sodium acetate 20 mM 49.8 CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0 2RN2 21.986666785346138 1331044 1992 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 293 158 155 K95A Ribonuclease HI Escherichia coli (strain K12) 114.2 0.3 yes 49.8 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0 2RN2 21.986666785346138 1331044 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 294 158 155 K95A Ribonuclease HI Escherichia coli (strain K12) 96.4 0.4 yes 52.0 Sodium acetate 20 mM CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0 2RN2 21.986666785346138 1331044 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7722 158 155 K95A Ribonuclease HI Escherichia coli (strain K12) -0.1 yes glycine-HCl 10 mM 49.8 CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0 2RN2 21.986666785346138 1331044 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 7723 158 155 K95A Ribonuclease HI Escherichia coli (strain K12) -0.1 yes Sodium acetate 20 mM 49.8 CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0 2RN2 21.986666785346138 1331044 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 295 159 155 K95N Ribonuclease HI Escherichia coli (strain K12) 108.7 2.9 yes 49.8 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0 2RN2 21.986666785346138 1331044 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 296 159 155 K95N Ribonuclease HI Escherichia coli (strain K12) 90.0 3.2 yes 52.0 Sodium acetate 20 mM CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0 2RN2 21.986666785346138 1331044 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4091 159 155 K95N Ribonuclease HI Escherichia coli (strain K12) 90.0 3.2 yes 55.9 Sodium acetate 20 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0 2RN2 21.986666785346138 7929430 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4104 159 155 K95N Ribonuclease HI Escherichia coli (strain K12) 108.7 2.9 yes 53.0 glycine-HCl 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0 2RN2 21.986666785346138 7929430 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7428 159 155 K95N Ribonuclease HI Escherichia coli (strain K12) -0.88 yes Sodium acetate 20 mM 52.7 NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0 2RN2 21.986666785346138 7929430 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 7665 159 155 K95N Ribonuclease HI Escherichia coli (strain K12) -0.88 yes glycine-HCl 10 mM 50.1 NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0 2RN2 21.986666785346138 7929430 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 7724 159 155 K95N Ribonuclease HI Escherichia coli (strain K12) -0.9 yes glycine-HCl 10 mM 49.8 CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0 2RN2 21.986666785346138 1331044 1992 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 7725 159 155 K95N Ribonuclease HI Escherichia coli (strain K12) -0.9 yes Sodium acetate 20 mM 49.8 CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0 2RN2 21.986666785346138 1331044 1992 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 3961 2042 155 Q105G Ribonuclease HI Escherichia coli (strain K12) -9.6 yes 38.2 Potassium phosphate 2 mM KF 5 mM CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 4.0 2RN2 11.977777798970541 10467093 10.1038/12277 1999 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 11061 2042 155 Q105G Ribonuclease HI Escherichia coli (strain K12) 2.2 7.5 2.1 yes Potassium phosphate 2 mM 25.0 KF 5 mM CD Urea 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 4.0 2RN2 11.977777798970541 10467093 10.1038/12277 1999 ProTherm SAAFEC_S1262.csv 2886 1525 155 Q113P Ribonuclease HI Escherichia coli (strain K12) 100.4 -0.6 yes 49.2 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 25.15444458855523 in pocket 1328237 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 2888 1525 155 Q113P Ribonuclease HI Escherichia coli (strain K12) 81.0 -2.1 yes 49.9 Sodium acetate 20 mM CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 25.15444458855523 in pocket 1328237 1992 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7465 1525 155 Q113P Ribonuclease HI Escherichia coli (strain K12) 0.6 yes Sodium acetate 20 mM 52.0 CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 25.15444458855523 in pocket 1328237 1992 ProTherm capriotti_S1615_map.csv 7733 1525 155 Q113P Ribonuclease HI Escherichia coli (strain K12) 0.2 yes glycine-HCl 10 mM 49.8 CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 25.15444458855523 in pocket 1328237 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 3966 2046 155 H114A Ribonuclease HI Escherichia coli (strain K12) -2.3 yes 47.1 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 12.804000091552734 in pocket 7764048 10.1016/0168-1656(93)90129-b 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3973 2046 155 H114A Ribonuclease HI Escherichia coli (strain K12) -7.7 yes 42.5 Sodium phosphate 20 mM CD Thermal 7.8 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 12.804000091552734 in pocket 7764048 10.1016/0168-1656(93)90129-b 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 10729 2046 155 H114A Ribonuclease HI Escherichia coli (strain K12) 1.57 2.63 6.63 4.23 yes Sodium acetate 20 mM 25.0 NaCl 0.1 M Fluorescence GdnHCl 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 8.0 2RN2 12.804000091552734 in pocket 1645658 10.1111/j.1432-1033.1991.tb16033.x 1991 ProTherm SAAFEC_S1262.csv 4088 2076 155 K117R Ribonuclease HI Escherichia coli (strain K12) 97.9 0.1 yes 52.8 Sodium acetate 20 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 1.0 2RN2 23.851110882229275 in pocket 7929430 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4101 2076 155 K117R Ribonuclease HI Escherichia coli (strain K12) 97.1 -0.2 yes 49.9 glycine-HCl 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 1.0 2RN2 23.851110882229275 in pocket 7929430 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7425 2076 155 K117R Ribonuclease HI Escherichia coli (strain K12) -0.03 yes Sodium acetate 20 mM 52.7 NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 1.0 2RN2 23.851110882229275 in pocket 7929430 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 7662 2076 155 K117R Ribonuclease HI Escherichia coli (strain K12) 0.06 yes glycine-HCl 10 mM 50.1 NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 1.0 2RN2 23.851110882229275 in pocket 7929430 1994 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 4089 2077 155 E119V Ribonuclease HI Escherichia coli (strain K12) 94.3 2.7 yes 55.4 Sodium acetate 20 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 22.426666577657063 in pocket 7929430 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4102 2077 155 E119V Ribonuclease HI Escherichia coli (strain K12) 111.0 0.3 yes 50.4 glycine-HCl 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 22.426666577657063 in pocket 7929430 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7426 2077 155 E119V Ribonuclease HI Escherichia coli (strain K12) -0.74 yes Sodium acetate 20 mM 52.7 NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 22.426666577657063 in pocket 7929430 1994 ProTherm capriotti_S1615_map.csv 7663 2077 155 E119V Ribonuclease HI Escherichia coli (strain K12) -0.09 yes glycine-HCl 10 mM 50.1 NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 22.426666577657063 in pocket 7929430 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 3967 2047 155 H124A Ribonuclease HI Escherichia coli (strain K12) 1.7 yes 51.1 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 9.0 2RN2 25.72599983215332 in tunnel in pocket 7764048 10.1016/0168-1656(93)90129-b 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3970 2047 155 H124A Ribonuclease HI Escherichia coli (strain K12) 0.0 yes 52.7 Sodium acetate 20 mM CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 9.0 2RN2 25.72599983215332 in tunnel in pocket 7764048 10.1016/0168-1656(93)90129-b 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3974 2047 155 H124A Ribonuclease HI Escherichia coli (strain K12) 0.1 yes 50.3 Sodium phosphate 20 mM CD Thermal 7.8 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 9.0 2RN2 25.72599983215332 in tunnel in pocket 7764048 10.1016/0168-1656(93)90129-b 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 10730 2047 155 H124A Ribonuclease HI Escherichia coli (strain K12) 1.82 -0.48 9.74 5.36 yes Sodium acetate 20 mM 25.0 NaCl 0.1 M Fluorescence GdnHCl 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 9.0 2RN2 25.72599983215332 in tunnel in pocket 1645658 10.1111/j.1432-1033.1991.tb16033.x 1991 ProTherm 11066 2047 155 H124A Ribonuclease HI Escherichia coli (strain K12) 1.82 -0.17 9.38 yes Sodium acetate 20 mM 25.0 CD GdnHCl 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 9.0 2RN2 25.72599983215332 in tunnel in pocket 7764048 10.1016/0168-1656(93)90129-b 1993 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 11070 2047 155 H124A Ribonuclease HI Escherichia coli (strain K12) 1.66 -0.05 8.54 yes Tris-HCl 20 mM 25.0 CD GdnHCl 8.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 9.0 2RN2 25.72599983215332 in tunnel in pocket 7764048 10.1016/0168-1656(93)90129-b 1993 ProTherm 14778 6929 155 H124A, H127A Ribonuclease HI Escherichia coli (strain K12) 3.6 yes 53.0 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 9.0, 7.0 2RN2 25.72599983215332, 29.089000129699706 in tunnel in pocket 7764048 10.1016/0168-1656(93)90129-b 1993 ProTherm 14780 6929 155 H124A, H127A Ribonuclease HI Escherichia coli (strain K12) -0.6 yes 52.1 Sodium acetate 20 mM CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 9.0, 7.0 2RN2 25.72599983215332, 29.089000129699706 in tunnel in pocket 7764048 10.1016/0168-1656(93)90129-b 1993 ProTherm 14782 6929 155 H124A, H127A Ribonuclease HI Escherichia coli (strain K12) -0.1 yes 50.1 Sodium phosphate 20 mM CD Thermal 7.8 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 9.0, 7.0 2RN2 25.72599983215332, 29.089000129699706 in tunnel in pocket 7764048 10.1016/0168-1656(93)90129-b 1993 ProTherm 2883 1523 155 A125T Ribonuclease HI Escherichia coli (strain K12) 96.4 0.4 yes 50.2 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0 2RN2 29.294000244140626 in tunnel in pocket 1328237 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, STRUM_Q306.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 2884 1523 155 A125T Ribonuclease HI Escherichia coli (strain K12) 88.8 0.0 yes 52.0 glycine-HCl 10 mM CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0 2RN2 29.294000244140626 in tunnel in pocket 1328237 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, STRUM_Q306.csv, STRUM_Q3421.csv, AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7466 1523 155 A125T Ribonuclease HI Escherichia coli (strain K12) 0.0 yes glycine-HCl 10 mM 52.0 CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0 2RN2 29.294000244140626 in tunnel in pocket 1328237 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 7734 1523 155 A125T Ribonuclease HI Escherichia coli (strain K12) -0.1 yes glycine-HCl 10 mM 49.8 CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 5.0 2RN2 29.294000244140626 in tunnel in pocket 1328237 1992 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3968 2048 155 H127A Ribonuclease HI Escherichia coli (strain K12) 0.9 yes 50.3 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 29.089000129699706 in tunnel in pocket 7764048 10.1016/0168-1656(93)90129-b 1993 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 10731 2048 155 H127A Ribonuclease HI Escherichia coli (strain K12) 1.74 0.58 8.68 4.98 yes Sodium acetate 20 mM 25.0 NaCl 0.1 M Fluorescence GdnHCl 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 29.089000129699706 in tunnel in pocket 1645658 10.1111/j.1432-1033.1991.tb16033.x 1991 ProTherm 11067 2048 155 H127A Ribonuclease HI Escherichia coli (strain K12) 1.74 0.24 8.97 yes Sodium acetate 20 mM 25.0 CD GdnHCl 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 29.089000129699706 in tunnel in pocket 7764048 10.1016/0168-1656(93)90129-b 1993 ProTherm SAAFEC_S983.csv 11071 2048 155 H127A Ribonuclease HI Escherichia coli (strain K12) 1.59 0.31 8.18 yes Tris-HCl 20 mM 25.0 CD GdnHCl 8.2 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 7.0 2RN2 29.089000129699706 in tunnel in pocket 7764048 10.1016/0168-1656(93)90129-b 1993 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 770 477 155 D134N Ribonuclease HI Escherichia coli (strain K12) 6.4 yes 53.4 glycine-NaOH 50 mM CD Thermal 9.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 783 477 155 D134N Ribonuclease HI Escherichia coli (strain K12) 110.5 -0.3 yes 49.7 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3935 477 155 D134N Ribonuclease HI Escherichia coli (strain K12) 96.9 3.2 yes 56.3 Sodium acetate 20 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3945 477 155 D134N Ribonuclease HI Escherichia coli (strain K12) 110.5 -0.3 yes 49.7 glycine-HCl 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7377 477 155 D134N Ribonuclease HI Escherichia coli (strain K12) -0.89 yes Sodium acetate 20 mM 53.1 NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm capriotti_S1615_map.csv 7687 477 155 D134N Ribonuclease HI Escherichia coli (strain K12) 0.1 yes glycine-HCl 10 mM 50.0 CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 7689 477 155 D134N Ribonuclease HI Escherichia coli (strain K12) 0.1 yes glycine-HCl 10 mM 50.0 NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 7809 477 155 D134N Ribonuclease HI Escherichia coli (strain K12) -1.8 yes glycine-NaOH 50 mM 47.0 CD Thermal 9.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm capriotti_S1615_map.csv 771 478 155 D134A Ribonuclease HI Escherichia coli (strain K12) 6.8 yes 53.8 glycine-NaOH 50 mM CD Thermal 9.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 784 478 155 D134A Ribonuclease HI Escherichia coli (strain K12) 104.8 2.9 yes 52.9 glycine-HCl 10 mM CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3944 478 155 D134A Ribonuclease HI Escherichia coli (strain K12) 117.5 5.5 yes 58.6 Sodium acetate 20 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3954 478 155 D134A Ribonuclease HI Escherichia coli (strain K12) 104.8 2.9 yes 52.9 glycine-HCl 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7386 478 155 D134A Ribonuclease HI Escherichia coli (strain K12) -1.51 yes Sodium acetate 20 mM 53.1 NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm capriotti_S1615_map.csv 7688 478 155 D134A Ribonuclease HI Escherichia coli (strain K12) -0.8 yes glycine-HCl 10 mM 50.0 CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 7698 478 155 D134A Ribonuclease HI Escherichia coli (strain K12) -0.89 yes glycine-HCl 10 mM 50.0 NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm capriotti_S1615_map.csv 7810 478 155 D134A Ribonuclease HI Escherichia coli (strain K12) -2.0 yes glycine-NaOH 50 mM 47.0 CD Thermal 9.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8955106 10.1074/jbc.271.51.32729 1996 ProTherm capriotti_S1615_map.csv 3927 2027 155 D134H Ribonuclease HI Escherichia coli (strain K12) 106.5 1.7 yes 53.6 glycine-HCl 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 7794925 10.1021/bi00025a018 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3931 2027 155 D134H Ribonuclease HI Escherichia coli (strain K12) 106.6 7.0 yes 59.5 Sodium acetate 10 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 7794925 10.1021/bi00025a018 1995 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3936 2027 155 D134H Ribonuclease HI Escherichia coli (strain K12) 111.5 7.0 yes 60.1 Sodium acetate 20 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3946 2027 155 D134H Ribonuclease HI Escherichia coli (strain K12) 106.5 1.7 yes 51.7 glycine-HCl 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7378 2027 155 D134H Ribonuclease HI Escherichia coli (strain K12) -1.94 yes Sodium acetate 20 mM 53.1 NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm capriotti_S1615_map.csv 7458 2027 155 D134H Ribonuclease HI Escherichia coli (strain K12) -1.9 yes Sodium acetate 10 mM 52.5 NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 7794925 10.1021/bi00025a018 1995 ProTherm capriotti_S1615_map.csv 7622 2027 155 D134H Ribonuclease HI Escherichia coli (strain K12) -0.5 yes glycine-HCl 10 mM 50.9 NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 7794925 10.1021/bi00025a018 1995 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 7690 2027 155 D134H Ribonuclease HI Escherichia coli (strain K12) -0.53 yes glycine-HCl 10 mM 50.0 NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm capriotti_S1615_map.csv 3937 2030 155 D134E Ribonuclease HI Escherichia coli (strain K12) 102.4 3.1 yes 56.2 Sodium acetate 20 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3947 2030 155 D134E Ribonuclease HI Escherichia coli (strain K12) 107.7 2.4 yes 52.4 glycine-HCl 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7379 2030 155 D134E Ribonuclease HI Escherichia coli (strain K12) -0.86 yes Sodium acetate 20 mM 53.1 NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm capriotti_S1615_map.csv, potapov_with_uniprot_mapping.csv 7691 2030 155 D134E Ribonuclease HI Escherichia coli (strain K12) -0.72 yes glycine-HCl 10 mM 50.0 NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv, potapov_with_uniprot_mapping.csv 3938 2031 155 D134Q Ribonuclease HI Escherichia coli (strain K12) 96.9 4.8 yes 57.9 Sodium acetate 20 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3948 2031 155 D134Q Ribonuclease HI Escherichia coli (strain K12) 113.6 1.6 yes 51.6 glycine-HCl 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7380 2031 155 D134Q Ribonuclease HI Escherichia coli (strain K12) -1.32 yes Sodium acetate 20 mM 53.1 NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm capriotti_S1615_map.csv 7692 2031 155 D134Q Ribonuclease HI Escherichia coli (strain K12) -0.48 yes glycine-HCl 10 mM 50.0 NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 3939 2032 155 D134S Ribonuclease HI Escherichia coli (strain K12) 105.3 3.9 yes 57.0 Sodium acetate 20 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3949 2032 155 D134S Ribonuclease HI Escherichia coli (strain K12) 106.2 0.9 yes 50.9 glycine-HCl 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7381 2032 155 D134S Ribonuclease HI Escherichia coli (strain K12) -1.08 yes Sodium acetate 20 mM 53.1 NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm capriotti_S1615_map.csv 7693 2032 155 D134S Ribonuclease HI Escherichia coli (strain K12) -0.26 yes glycine-HCl 10 mM 50.0 NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 3940 2033 155 D134T Ribonuclease HI Escherichia coli (strain K12) 90.2 3.9 yes 57.0 Sodium acetate 20 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3950 2033 155 D134T Ribonuclease HI Escherichia coli (strain K12) 107.2 0.4 yes 50.4 glycine-HCl 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7382 2033 155 D134T Ribonuclease HI Escherichia coli (strain K12) -1.08 yes Sodium acetate 20 mM 53.1 NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm capriotti_S1615_map.csv 7694 2033 155 D134T Ribonuclease HI Escherichia coli (strain K12) -0.12 yes glycine-HCl 10 mM 50.0 NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 3941 2034 155 D134V Ribonuclease HI Escherichia coli (strain K12) 99.0 4.1 yes 57.2 Sodium acetate 20 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3951 2034 155 D134V Ribonuclease HI Escherichia coli (strain K12) 106.7 1.1 yes 51.1 glycine-HCl 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7383 2034 155 D134V Ribonuclease HI Escherichia coli (strain K12) -1.12 yes Sodium acetate 20 mM 53.1 NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm capriotti_S1615_map.csv 7695 2034 155 D134V Ribonuclease HI Escherichia coli (strain K12) -0.31 yes glycine-HCl 10 mM 50.0 NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 3942 2035 155 D134I Ribonuclease HI Escherichia coli (strain K12) 101.4 4.6 yes 57.7 Sodium acetate 20 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3952 2035 155 D134I Ribonuclease HI Escherichia coli (strain K12) 104.8 2.3 yes 52.3 glycine-HCl 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7384 2035 155 D134I Ribonuclease HI Escherichia coli (strain K12) -1.27 yes Sodium acetate 20 mM 53.1 NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm capriotti_S1615_map.csv 7696 2035 155 D134I Ribonuclease HI Escherichia coli (strain K12) -0.69 yes glycine-HCl 10 mM 50.0 NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 3943 2036 155 D134L Ribonuclease HI Escherichia coli (strain K12) 96.4 5.5 yes 58.6 Sodium acetate 20 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 3953 2036 155 D134L Ribonuclease HI Escherichia coli (strain K12) 118.2 3.8 yes 53.8 glycine-HCl 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7385 2036 155 D134L Ribonuclease HI Escherichia coli (strain K12) -1.51 yes Sodium acetate 20 mM 53.1 NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm capriotti_S1615_map.csv 7697 2036 155 D134L Ribonuclease HI Escherichia coli (strain K12) -1.15 yes glycine-HCl 10 mM 50.0 NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI binding site 9.0 2RN2 17.53499972820282 in tunnel in pocket 8125123 10.1111/j.1432-1033.1994.tb18664.x 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 4092 2079 155 E135K Ribonuclease HI Escherichia coli (strain K12) 89.9 -0.8 yes 51.9 Sodium acetate 20 mM NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 20.72111087375217 in tunnel 7929430 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 4105 2079 155 E135K Ribonuclease HI Escherichia coli (strain K12) 99.0 -3.7 yes 46.4 glycine-HCl 10 mM NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 20.72111087375217 in tunnel 7929430 1994 ProTherm AUTOMUTE_S1749.csv, Saraboji_S1791.csv 7429 2079 155 E135K Ribonuclease HI Escherichia coli (strain K12) 0.22 yes Sodium acetate 20 mM 52.7 NaCl 0.1 M CD Thermal 5.5 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 20.72111087375217 in tunnel 7929430 1994 ProTherm capriotti_S1615_map.csv, khan_protherm_data_mapped.csv 7666 2079 155 E135K Ribonuclease HI Escherichia coli (strain K12) 1.1 yes glycine-HCl 10 mM 50.1 NaCl 0.1 M CD Thermal 3.0 3.1.26.4 P0A7Y4 IPR050092:RNase_H, IPR012337:RNaseH-like_sf, IPR002156:RNaseH_domain, IPR036397:RNaseH_sf, IPR022892:RNaseHI 3.0 2RN2 20.72111087375217 in tunnel 7929430 1994 ProTherm capriotti_S1615_map.csv 22240 225 504 Transcriptional coactivator YAP1 Homo sapiens 27.0 yes 51.6 potassium phosphate 20 mM NaCl 100 mM Fluorescence Thermal 7.0 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 11420447 10.1110/ps.640101 2001 ProTherm 22241 225 504 Transcriptional coactivator YAP1 Homo sapiens 25.0 yes 52.9 potassium 20 mM NaCl 2 M Fluorescence Thermal 7.0 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 11420447 10.1110/ps.640101 2001 ProTherm 5093013 4905550 503 162Q Transcriptional coactivator YAP1 Homo sapiens -0.831944785911667 0.378680207860701 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093014 4905551 504 Q162A Transcriptional coactivator YAP1 Homo sapiens -0.137898448615802 0.106156561314978 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093015 4905552 504 Q162C Transcriptional coactivator YAP1 Homo sapiens -0.439621150531082 0.485116332747862 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093016 4905553 504 Q162D Transcriptional coactivator YAP1 Homo sapiens 0.150301498615939 0.0721119041562959 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093017 4905554 504 Q162E Transcriptional coactivator YAP1 Homo sapiens -0.263987783847857 0.0932829307649319 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093018 4905555 504 Q162F Transcriptional coactivator YAP1 Homo sapiens 0.545249768187046 0.963535613157464 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093019 4905556 504 Q162G Transcriptional coactivator YAP1 Homo sapiens -0.334281161413973 0.172239153082065 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093020 4905557 504 Q162H Transcriptional coactivator YAP1 Homo sapiens -0.770613977154631 0.219112210233083 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093021 4905558 504 Q162I Transcriptional coactivator YAP1 Homo sapiens 0.706453883519471 0.192079391819348 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093022 4905559 504 Q162K Transcriptional coactivator YAP1 Homo sapiens 0.147896019059694 0.0924997176444181 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093023 4905560 504 Q162L Transcriptional coactivator YAP1 Homo sapiens -0.132126603036015 0.120170854751372 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093024 4905561 504 Q162M Transcriptional coactivator YAP1 Homo sapiens -0.0706429226810122 0.0675877315814345 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093025 4905562 504 Q162N Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093026 4905563 504 Q162P Transcriptional coactivator YAP1 Homo sapiens -0.404407018395979 0.123191664245354 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094007 4905969 504 Q162R Transcriptional coactivator YAP1 Homo sapiens -0.485748052145343 0.0474730419131715 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094008 4905970 504 Q162S Transcriptional coactivator YAP1 Homo sapiens -0.447082705898643 0.223148731112797 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094009 4905971 504 Q162T Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094010 4905972 504 Q162V Transcriptional coactivator YAP1 Homo sapiens -0.0538226957206439 0.0787039261647006 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094011 4905973 504 Q162W Transcriptional coactivator YAP1 Homo sapiens -0.564951929351972 0.338107157507683 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094012 4905974 504 Q162Y Transcriptional coactivator YAP1 Homo sapiens 0.0787571556490021 0.120133579608414 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093027 4905564 503 163S Transcriptional coactivator YAP1 Homo sapiens -1.27634030934975 0.230886441625074 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093043 4905564 503 163S Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093028 4905565 504 S163A Transcriptional coactivator YAP1 Homo sapiens -0.282895128734928 0.0387292361318084 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093029 4905566 504 S163C Transcriptional coactivator YAP1 Homo sapiens -0.345702294224133 0.0818896455323906 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093030 4905567 504 S163D Transcriptional coactivator YAP1 Homo sapiens 0.333833714659013 0.086149962309319 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093031 4905568 504 S163E Transcriptional coactivator YAP1 Homo sapiens -0.188099508851403 0.0743169899332892 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093032 4905569 504 S163F Transcriptional coactivator YAP1 Homo sapiens -0.27742206445667 0.114840726867608 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093033 4905570 504 S163G Transcriptional coactivator YAP1 Homo sapiens -0.100214294361746 0.0361019767269382 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093034 4905571 504 S163H Transcriptional coactivator YAP1 Homo sapiens -0.314713886953136 0.0902601632381488 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093035 4905572 504 S163I Transcriptional coactivator YAP1 Homo sapiens -0.387852938857119 0.127610436639719 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093036 4905573 504 S163K Transcriptional coactivator YAP1 Homo sapiens -0.240036691504144 0.0648907879647585 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093037 4905574 504 S163L Transcriptional coactivator YAP1 Homo sapiens -0.140174843046629 0.0567507089637915 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093038 4905575 504 S163M Transcriptional coactivator YAP1 Homo sapiens -0.0418163286621004 0.0767090533388586 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093039 4905576 504 S163N Transcriptional coactivator YAP1 Homo sapiens -0.0894494651386836 0.116553715489799 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093040 4905577 504 S163P Transcriptional coactivator YAP1 Homo sapiens -0.64974881847587 0.0920030299904922 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093041 4905578 504 S163Q Transcriptional coactivator YAP1 Homo sapiens -0.299138098617584 0.072830407918714 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093042 4905579 504 S163R Transcriptional coactivator YAP1 Homo sapiens -0.190977091871958 0.0640613072543476 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094003 4905965 504 S163T Transcriptional coactivator YAP1 Homo sapiens -0.268858209141719 0.0848053739327035 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094004 4905966 504 S163V Transcriptional coactivator YAP1 Homo sapiens -0.325472914597528 0.0498593399999371 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094005 4905967 504 S163W Transcriptional coactivator YAP1 Homo sapiens -0.484806020808725 0.0514614241938681 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094006 4905968 504 S163Y Transcriptional coactivator YAP1 Homo sapiens -0.346157718149765 0.149688924428071 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093044 4905580 504 S164A Transcriptional coactivator YAP1 Homo sapiens -0.419644139576642 0.110644299975789 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093045 4905581 504 S164C Transcriptional coactivator YAP1 Homo sapiens -0.402959524517696 0.817924690896602 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093046 4905582 504 S164D Transcriptional coactivator YAP1 Homo sapiens -0.127843587582539 0.522363120489898 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093047 4905583 504 S164E Transcriptional coactivator YAP1 Homo sapiens -0.232793420534058 0.0603512702143137 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093048 4905584 504 S164F Transcriptional coactivator YAP1 Homo sapiens -0.621494477673067 0.470239489602636 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093049 4905585 504 S164G Transcriptional coactivator YAP1 Homo sapiens -0.523332129167334 0.287837276045103 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093050 4905586 504 S164H Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093051 4905587 504 S164I Transcriptional coactivator YAP1 Homo sapiens -0.272352935093345 0.504092281302711 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093052 4905588 504 S164K Transcriptional coactivator YAP1 Homo sapiens -0.118446480531041 0.0415403983285594 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093053 4905589 504 S164L Transcriptional coactivator YAP1 Homo sapiens -0.843655417497483 0.20930210329998 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093054 4905590 504 S164M Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093055 4905591 504 S164N Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093056 4905592 504 S164P Transcriptional coactivator YAP1 Homo sapiens -0.0879142223830099 0.0986317687399077 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093057 4905593 504 S164Q Transcriptional coactivator YAP1 Homo sapiens -1.04470796600698 0.515265614183908 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093058 4905594 504 S164R Transcriptional coactivator YAP1 Homo sapiens -0.43788067692994 0.128143964318203 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093999 4905961 504 S164T Transcriptional coactivator YAP1 Homo sapiens -0.244917269560679 1.06065549049585 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094000 4905962 504 S164V Transcriptional coactivator YAP1 Homo sapiens -0.660850646899953 0.183673266924499 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094001 4905963 504 S164W Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094002 4905964 504 S164Y Transcriptional coactivator YAP1 Homo sapiens -0.700204568015105 0.398208104106312 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093059 4905595 503 165F Transcriptional coactivator YAP1 Homo sapiens -1.37977994060953 0.232922433139743 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094013 4905595 503 165F Transcriptional coactivator YAP1 Homo sapiens -0.917884937405925 0.252514437205242 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093060 4905596 504 F165A Transcriptional coactivator YAP1 Homo sapiens -0.241427619990389 0.0443551067402727 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094014 4905596 504 F165A Transcriptional coactivator YAP1 Homo sapiens -0.0341312535893352 0.107127302633974 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093061 4905597 504 F165C Transcriptional coactivator YAP1 Homo sapiens -0.0601232101567774 0.05591006021444 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094015 4905597 504 F165C Transcriptional coactivator YAP1 Homo sapiens 0.0703489792932703 0.0776147073746779 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093062 4905598 504 F165D Transcriptional coactivator YAP1 Homo sapiens -0.0427677875640579 0.0618979203240483 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094016 4905598 504 F165D Transcriptional coactivator YAP1 Homo sapiens 0.265545391071512 0.192888252001466 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093063 4905599 504 F165E Transcriptional coactivator YAP1 Homo sapiens -0.0534426923177279 0.0497043943375954 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094017 4905599 504 F165E Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093984 4905946 504 F165G Transcriptional coactivator YAP1 Homo sapiens -0.612364895918011 0.0521321447039615 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094918 4905946 504 F165G Transcriptional coactivator YAP1 Homo sapiens -0.208662094583062 0.087480162701593 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093985 4905947 504 F165H Transcriptional coactivator YAP1 Homo sapiens 0.0214143520700488 0.0736002774082857 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094919 4905947 504 F165H Transcriptional coactivator YAP1 Homo sapiens -0.783276231455739 0.30212286312238 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093986 4905948 504 F165I Transcriptional coactivator YAP1 Homo sapiens 0.0699655883712344 0.0715359451818114 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094920 4905948 504 F165I Transcriptional coactivator YAP1 Homo sapiens 0.0601136429213111 0.0961952234848879 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093987 4905949 504 F165K Transcriptional coactivator YAP1 Homo sapiens 0.137167449703323 0.079224690370109 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094921 4905949 504 F165K Transcriptional coactivator YAP1 Homo sapiens -0.659242764060312 0.426532802660224 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093988 4905950 504 F165L Transcriptional coactivator YAP1 Homo sapiens -0.235954555712132 0.0545864082848516 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094922 4905950 504 F165L Transcriptional coactivator YAP1 Homo sapiens -0.272699920961757 0.0696761345595208 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093989 4905951 504 F165M Transcriptional coactivator YAP1 Homo sapiens -0.0915547129987316 0.0679182982821047 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094923 4905951 504 F165M Transcriptional coactivator YAP1 Homo sapiens -0.0147130302646359 0.101442091353779 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093990 4905952 504 F165N Transcriptional coactivator YAP1 Homo sapiens -0.231192184821008 0.0980843897923486 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094924 4905952 504 F165N Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093991 4905953 504 F165P Transcriptional coactivator YAP1 Homo sapiens -0.25225119019749 0.0642057883191624 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094925 4905953 504 F165P Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093992 4905954 504 F165Q Transcriptional coactivator YAP1 Homo sapiens -0.140173392651961 0.072190239972294 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094926 4905954 504 F165Q Transcriptional coactivator YAP1 Homo sapiens -0.582037980419019 0.314225393595264 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093993 4905955 504 F165R Transcriptional coactivator YAP1 Homo sapiens -0.160385367542555 0.0441949976729143 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094927 4905955 504 F165R Transcriptional coactivator YAP1 Homo sapiens -1.1573871663928 0.473813082892422 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093994 4905956 504 F165S Transcriptional coactivator YAP1 Homo sapiens -0.00581173143314619 0.0473852930357806 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094928 4905956 504 F165S Transcriptional coactivator YAP1 Homo sapiens -0.166452140030982 0.0830522918352941 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093995 4905957 504 F165T Transcriptional coactivator YAP1 Homo sapiens -0.112503488380475 0.0736553924056552 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094929 4905957 504 F165T Transcriptional coactivator YAP1 Homo sapiens 0.122990585698201 0.168368519310152 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093996 4905958 504 F165V Transcriptional coactivator YAP1 Homo sapiens -0.186973277391998 0.0401855121498038 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094930 4905958 504 F165V Transcriptional coactivator YAP1 Homo sapiens -0.340652008715769 0.0816399543251126 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093997 4905959 504 F165W Transcriptional coactivator YAP1 Homo sapiens -0.610897096514381 0.0765899034169137 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094931 4905959 504 F165W Transcriptional coactivator YAP1 Homo sapiens -0.943210201417026 0.349403993818756 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093998 4905960 504 F165Y Transcriptional coactivator YAP1 Homo sapiens 0.0225282551747796 0.073826321417234 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094932 4905960 504 F165Y Transcriptional coactivator YAP1 Homo sapiens -0.665402888711429 0.225992144864808 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093064 4905600 503 166E Transcriptional coactivator YAP1 Homo sapiens -1.18019738159961 0.197979017169351 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094018 4905600 503 166E Transcriptional coactivator YAP1 Homo sapiens -0.91804305287086 0.681781907427081 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093065 4905601 504 E166A Transcriptional coactivator YAP1 Homo sapiens -0.0965368186820001 0.0537639112247653 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094019 4905601 504 E166A Transcriptional coactivator YAP1 Homo sapiens -0.428567325588003 0.0745134897527128 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093066 4905602 504 E166C Transcriptional coactivator YAP1 Homo sapiens -0.0689009986852028 0.0554475511108566 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094020 4905602 504 E166C Transcriptional coactivator YAP1 Homo sapiens -0.147371976216698 0.173371445704232 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093067 4905603 504 E166D Transcriptional coactivator YAP1 Homo sapiens -0.0372881965097964 0.0695187435300613 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094021 4905603 504 E166D Transcriptional coactivator YAP1 Homo sapiens -0.00748054115815175 0.0696466518013797 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093968 4905930 504 E166F Transcriptional coactivator YAP1 Homo sapiens -0.193948950545908 0.0757193040176759 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094902 4905930 504 E166F Transcriptional coactivator YAP1 Homo sapiens -0.0313119648420945 0.218873192725973 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093969 4905931 504 E166G Transcriptional coactivator YAP1 Homo sapiens -0.292789721157419 0.0457683060366398 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094903 4905931 504 E166G Transcriptional coactivator YAP1 Homo sapiens -0.281890603836121 0.0514224589197897 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093970 4905932 504 E166H Transcriptional coactivator YAP1 Homo sapiens -0.211666971805532 0.0850628189862057 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094904 4905932 504 E166H Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093971 4905933 504 E166I Transcriptional coactivator YAP1 Homo sapiens -0.0942132864244757 0.0735876589746774 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094905 4905933 504 E166I Transcriptional coactivator YAP1 Homo sapiens -0.165270703544896 0.123102279993466 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093972 4905934 504 E166K Transcriptional coactivator YAP1 Homo sapiens -0.26731063803137 0.0773963953718428 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094906 4905934 504 E166K Transcriptional coactivator YAP1 Homo sapiens 0.28843917800015 0.135224725502499 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093973 4905935 504 E166L Transcriptional coactivator YAP1 Homo sapiens -0.184780280654559 0.0470733494026426 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094907 4905935 504 E166L Transcriptional coactivator YAP1 Homo sapiens -0.179011369766994 0.0960489436464187 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093974 4905936 504 E166M Transcriptional coactivator YAP1 Homo sapiens -0.0609499351173198 0.0775839314023659 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094908 4905936 504 E166M Transcriptional coactivator YAP1 Homo sapiens -0.370190047028366 0.222455560456159 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093975 4905937 504 E166N Transcriptional coactivator YAP1 Homo sapiens -0.0373955257152002 0.0601031149386575 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094909 4905937 504 E166N Transcriptional coactivator YAP1 Homo sapiens 0.271516358315228 0.0960487310303744 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093976 4905938 504 E166P Transcriptional coactivator YAP1 Homo sapiens -0.107798408078722 0.0759425922767557 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094910 4905938 504 E166P Transcriptional coactivator YAP1 Homo sapiens 0.0077293019299672 0.11432960026217 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093977 4905939 504 E166Q Transcriptional coactivator YAP1 Homo sapiens -0.0602551960715307 0.0483551937059369 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094911 4905939 504 E166Q Transcriptional coactivator YAP1 Homo sapiens 0.0188441600051254 0.27894913173543 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093978 4905940 504 E166R Transcriptional coactivator YAP1 Homo sapiens -0.141829743362381 0.0340380868708375 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094912 4905940 504 E166R Transcriptional coactivator YAP1 Homo sapiens -0.245115824096155 0.0637959543667145 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093979 4905941 504 E166S Transcriptional coactivator YAP1 Homo sapiens -0.0321305930717461 0.057734620446437 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094913 4905941 504 E166S Transcriptional coactivator YAP1 Homo sapiens 0.115462560290158 0.0833247947320548 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093980 4905942 504 E166T Transcriptional coactivator YAP1 Homo sapiens -0.00933981646212748 0.0696517374691086 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094914 4905942 504 E166T Transcriptional coactivator YAP1 Homo sapiens -0.136802832655209 0.0798933843933126 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093981 4905943 504 E166V Transcriptional coactivator YAP1 Homo sapiens -0.0880752161911155 0.0461674183893016 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094915 4905943 504 E166V Transcriptional coactivator YAP1 Homo sapiens -0.229056934271185 0.0464375198430568 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093982 4905944 504 E166W Transcriptional coactivator YAP1 Homo sapiens -0.223507268674633 0.0638590642218949 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094916 4905944 504 E166W Transcriptional coactivator YAP1 Homo sapiens -0.2606311255679 0.0561139453321981 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093983 4905945 504 E166Y Transcriptional coactivator YAP1 Homo sapiens -0.147093225611168 0.0546625177450349 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094917 4905945 504 E166Y Transcriptional coactivator YAP1 Homo sapiens -0.138452733158874 0.29164762498045 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093068 4905604 503 167I Transcriptional coactivator YAP1 Homo sapiens -1.33635351939934 0.078226311200654 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094022 4905604 503 167I Transcriptional coactivator YAP1 Homo sapiens -1.39163140060447 0.0981385341296678 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093069 4905605 504 I167A Transcriptional coactivator YAP1 Homo sapiens -0.349018621631642 0.0531905919685759 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094023 4905605 504 I167A Transcriptional coactivator YAP1 Homo sapiens -0.409566538430253 0.0367645812570417 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093070 4905606 504 I167C Transcriptional coactivator YAP1 Homo sapiens -0.0992512323024475 0.0581195116793828 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094024 4905606 504 I167C Transcriptional coactivator YAP1 Homo sapiens -0.355477725483877 0.0662483528679344 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093071 4905607 504 I167D Transcriptional coactivator YAP1 Homo sapiens -0.879666178903775 0.108066223454097 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094025 4905607 504 I167D Transcriptional coactivator YAP1 Homo sapiens -0.348875997308777 0.088483993918685 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093072 4905608 504 I167E Transcriptional coactivator YAP1 Homo sapiens -0.652659325455379 0.0635716395106131 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094026 4905608 504 I167E Transcriptional coactivator YAP1 Homo sapiens -0.665443427503873 0.0870175101892253 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093073 4905609 504 I167F Transcriptional coactivator YAP1 Homo sapiens -0.0958928434495776 0.0507463433628656 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094027 4905609 504 I167F Transcriptional coactivator YAP1 Homo sapiens 0.13207850415116 0.0853546401068594 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093074 4905610 504 I167G Transcriptional coactivator YAP1 Homo sapiens -0.434773206354568 0.0561347336004274 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094028 4905610 504 I167G Transcriptional coactivator YAP1 Homo sapiens -0.95238883604888 0.0565182063916033 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093075 4905611 504 I167H Transcriptional coactivator YAP1 Homo sapiens 0.231506920463881 0.111861036062453 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094029 4905611 504 I167H Transcriptional coactivator YAP1 Homo sapiens -0.461814805153253 0.0930093846772968 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093956 4905918 504 I167K Transcriptional coactivator YAP1 Homo sapiens -0.19354574082831 0.061550362249847 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094890 4905918 504 I167K Transcriptional coactivator YAP1 Homo sapiens -0.627679699669915 0.099056184976809 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093957 4905919 504 I167L Transcriptional coactivator YAP1 Homo sapiens -0.0937513357228393 0.0557343521524314 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094891 4905919 504 I167L Transcriptional coactivator YAP1 Homo sapiens -0.673663801624128 0.0623508527241085 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093958 4905920 504 I167M Transcriptional coactivator YAP1 Homo sapiens 0.120878792388636 0.0673026565095141 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094892 4905920 504 I167M Transcriptional coactivator YAP1 Homo sapiens -0.446723318329787 0.073483081530085 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093959 4905921 504 I167N Transcriptional coactivator YAP1 Homo sapiens -0.296243836058352 0.0901497882039431 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094893 4905921 504 I167N Transcriptional coactivator YAP1 Homo sapiens -0.322191266310508 0.16231888413005 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093960 4905922 504 I167P Transcriptional coactivator YAP1 Homo sapiens -0.295287300775058 0.068523424693355 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094894 4905922 504 I167P Transcriptional coactivator YAP1 Homo sapiens -0.404814569840446 0.0721156060052481 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093961 4905923 504 I167Q Transcriptional coactivator YAP1 Homo sapiens -0.272434882392065 0.0940501895441019 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094895 4905923 504 I167Q Transcriptional coactivator YAP1 Homo sapiens -1.00064466956428 0.118026709784256 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093962 4905924 504 I167R Transcriptional coactivator YAP1 Homo sapiens -0.247771646266551 0.0528226631012678 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094896 4905924 504 I167R Transcriptional coactivator YAP1 Homo sapiens -0.769089000668624 0.0587641263650149 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093963 4905925 504 I167S Transcriptional coactivator YAP1 Homo sapiens -0.0544862512810792 0.0409466285075565 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094897 4905925 504 I167S Transcriptional coactivator YAP1 Homo sapiens -0.331848287042007 0.0577651853169415 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093964 4905926 504 I167T Transcriptional coactivator YAP1 Homo sapiens -0.141071912148551 0.0462299231475026 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094898 4905926 504 I167T Transcriptional coactivator YAP1 Homo sapiens -0.37079671147473 0.0709832129533774 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093965 4905927 504 I167V Transcriptional coactivator YAP1 Homo sapiens -0.263534535514226 0.0532484917237072 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094899 4905927 504 I167V Transcriptional coactivator YAP1 Homo sapiens -0.475493812722508 0.055124309779663 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093966 4905928 504 I167W Transcriptional coactivator YAP1 Homo sapiens -0.469843749417576 0.061511259609608 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094900 4905928 504 I167W Transcriptional coactivator YAP1 Homo sapiens -0.879938997622014 0.201322943094361 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093967 4905929 504 I167Y Transcriptional coactivator YAP1 Homo sapiens -0.0982925214271519 0.0722351514431768 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094901 4905929 504 I167Y Transcriptional coactivator YAP1 Homo sapiens -0.06466220882875 0.0776828153808644 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093076 4905612 503 168P Transcriptional coactivator YAP1 Homo sapiens -1.0849662081974 0.256420422189292 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094030 4905612 503 168P Transcriptional coactivator YAP1 Homo sapiens -0.9255345791913 0.314922348988436 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093077 4905613 504 P168A Transcriptional coactivator YAP1 Homo sapiens 0.0299977877130134 0.0408946101028024 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094031 4905613 504 P168A Transcriptional coactivator YAP1 Homo sapiens 0.0498584623852187 0.0413408652094542 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093078 4905614 504 P168C Transcriptional coactivator YAP1 Homo sapiens -0.020655070461551 0.0516606431534388 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094032 4905614 504 P168C Transcriptional coactivator YAP1 Homo sapiens -0.182615211717653 0.117484113639236 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093079 4905615 504 P168D Transcriptional coactivator YAP1 Homo sapiens 0.0324431531226178 0.066075492085189 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094033 4905615 504 P168D Transcriptional coactivator YAP1 Homo sapiens 0.117081985827475 0.0564649106365021 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093080 4905616 504 P168E Transcriptional coactivator YAP1 Homo sapiens -0.240351427147017 0.0662907596617569 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094034 4905616 504 P168E Transcriptional coactivator YAP1 Homo sapiens 0.112381753808445 0.0692054805966864 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093081 4905617 504 P168F Transcriptional coactivator YAP1 Homo sapiens -0.297445488040474 0.0844325499833923 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094035 4905617 504 P168F Transcriptional coactivator YAP1 Homo sapiens -0.153562646706178 0.147314286396682 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093082 4905618 504 P168G Transcriptional coactivator YAP1 Homo sapiens -0.395380487182057 0.0459555955000693 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094036 4905618 504 P168G Transcriptional coactivator YAP1 Homo sapiens 0.0551738634923848 0.0515170376234898 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093083 4905619 504 P168H Transcriptional coactivator YAP1 Homo sapiens 0.0399736022368914 0.0823074317163981 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094037 4905619 504 P168H Transcriptional coactivator YAP1 Homo sapiens -0.18098586409827 0.18724024852902 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093084 4905620 504 P168I Transcriptional coactivator YAP1 Homo sapiens -0.0398010052714449 0.0449322695423313 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094038 4905620 504 P168I Transcriptional coactivator YAP1 Homo sapiens 0.0900095849084565 0.0767495018184607 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093085 4905621 504 P168K Transcriptional coactivator YAP1 Homo sapiens -0.0568750512986465 0.0650411141200838 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094039 4905621 504 P168K Transcriptional coactivator YAP1 Homo sapiens -0.141290448629953 0.0712567080583448 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093086 4905622 504 P168L Transcriptional coactivator YAP1 Homo sapiens -0.0675659103936603 0.0549450981381269 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094040 4905622 504 P168L Transcriptional coactivator YAP1 Homo sapiens 0.0565636637018717 0.0617623952983364 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093087 4905623 504 P168M Transcriptional coactivator YAP1 Homo sapiens -0.129578984802344 0.0550573514334272 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094041 4905623 504 P168M Transcriptional coactivator YAP1 Homo sapiens -0.00284551139270294 0.0760876280725964 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093088 4905624 504 P168N Transcriptional coactivator YAP1 Homo sapiens 0.0351329100337156 0.0911763050299498 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094042 4905624 504 P168N Transcriptional coactivator YAP1 Homo sapiens 0.129128102176609 0.0968946593985762 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093949 4905911 504 P168Q Transcriptional coactivator YAP1 Homo sapiens -0.0621508619021076 0.0792355683301161 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094883 4905911 504 P168Q Transcriptional coactivator YAP1 Homo sapiens -0.259240616638265 0.096310532252906 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093950 4905912 504 P168R Transcriptional coactivator YAP1 Homo sapiens -0.0425458771799124 0.0420713515565077 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094884 4905912 504 P168R Transcriptional coactivator YAP1 Homo sapiens -0.00620059257154612 0.0533886966613452 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093951 4905913 504 P168S Transcriptional coactivator YAP1 Homo sapiens 0.0662692575608094 0.0477226040716552 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094885 4905913 504 P168S Transcriptional coactivator YAP1 Homo sapiens 0.187613814918832 0.0655846010136789 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093952 4905914 504 P168T Transcriptional coactivator YAP1 Homo sapiens 0.0937962979575354 0.0647540520074688 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094886 4905914 504 P168T Transcriptional coactivator YAP1 Homo sapiens 0.110346309544474 0.0778502150797327 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093953 4905915 504 P168V Transcriptional coactivator YAP1 Homo sapiens -0.0495331534911631 0.0580320166210588 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094887 4905915 504 P168V Transcriptional coactivator YAP1 Homo sapiens -0.203768381963731 0.0645099615666379 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093954 4905916 504 P168W Transcriptional coactivator YAP1 Homo sapiens -0.346679135032773 0.0674803298562974 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094888 4905916 504 P168W Transcriptional coactivator YAP1 Homo sapiens -0.258448267513223 0.0779210162224802 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093955 4905917 504 P168Y Transcriptional coactivator YAP1 Homo sapiens -0.236034327418851 0.0788117630082381 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094889 4905917 504 P168Y Transcriptional coactivator YAP1 Homo sapiens -0.301697914521865 0.194212566469312 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093089 4905625 503 169D Transcriptional coactivator YAP1 Homo sapiens -1.2779834324608 0.15812188162427 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093092 4905625 503 169D Transcriptional coactivator YAP1 Homo sapiens -1.22030231707365 0.0824373145588833 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094043 4905625 503 169D Transcriptional coactivator YAP1 Homo sapiens -0.980833248301681 0.241951034276949 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094046 4905625 503 169D Transcriptional coactivator YAP1 Homo sapiens -0.941042368229479 0.149981342056214 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093090 4905626 504 D169A Transcriptional coactivator YAP1 Homo sapiens -0.21412829155648 0.0581686583026951 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094044 4905626 504 D169A Transcriptional coactivator YAP1 Homo sapiens -0.0920918047021704 0.0636818716845518 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093091 4905627 504 D169C Transcriptional coactivator YAP1 Homo sapiens -0.311003777393369 0.0653517596499942 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094045 4905627 504 D169C Transcriptional coactivator YAP1 Homo sapiens -0.169028337767589 0.0465816806082846 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093932 4905894 504 D169E Transcriptional coactivator YAP1 Homo sapiens -0.0954178391959326 0.0505517221543913 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094866 4905894 504 D169E Transcriptional coactivator YAP1 Homo sapiens -0.298856655450048 0.054721331503725 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093933 4905895 504 D169F Transcriptional coactivator YAP1 Homo sapiens -0.416778884910762 0.0635901537985452 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094867 4905895 504 D169F Transcriptional coactivator YAP1 Homo sapiens -0.44253478225734 0.0799462549163252 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093934 4905896 504 D169G Transcriptional coactivator YAP1 Homo sapiens -0.171847111403408 0.0446258229049836 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094868 4905896 504 D169G Transcriptional coactivator YAP1 Homo sapiens -0.265717610067384 0.049479049054189 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093935 4905897 504 D169H Transcriptional coactivator YAP1 Homo sapiens -0.121256620199551 0.0719300464208966 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094869 4905897 504 D169H Transcriptional coactivator YAP1 Homo sapiens -0.22932979152802 0.063412508418045 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093936 4905898 504 D169I Transcriptional coactivator YAP1 Homo sapiens -0.326933462027819 0.0725893523249558 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094870 4905898 504 D169I Transcriptional coactivator YAP1 Homo sapiens -0.267237106063886 0.088689664505525 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093937 4905899 504 D169K Transcriptional coactivator YAP1 Homo sapiens -0.295811618447402 0.0635965572910027 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094871 4905899 504 D169K Transcriptional coactivator YAP1 Homo sapiens -0.143824123157702 0.0893740755520837 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093938 4905900 504 D169L Transcriptional coactivator YAP1 Homo sapiens -0.377306394031533 0.0383928025847077 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094872 4905900 504 D169L Transcriptional coactivator YAP1 Homo sapiens -0.377096524866944 0.0516654507096034 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093939 4905901 504 D169M Transcriptional coactivator YAP1 Homo sapiens -0.217204578646498 0.0679842187197479 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094873 4905901 504 D169M Transcriptional coactivator YAP1 Homo sapiens -0.24311156351868 0.0812700732800686 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093940 4905902 504 D169N Transcriptional coactivator YAP1 Homo sapiens -0.100831437292817 0.0589844907992836 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094874 4905902 504 D169N Transcriptional coactivator YAP1 Homo sapiens -0.0840861019146305 0.0575157583481874 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093941 4905903 504 D169P Transcriptional coactivator YAP1 Homo sapiens -0.361084454871557 0.0558363656613783 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094875 4905903 504 D169P Transcriptional coactivator YAP1 Homo sapiens -0.256296593145043 0.241063858396155 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093942 4905904 504 D169Q Transcriptional coactivator YAP1 Homo sapiens -0.290398020350517 0.0767846189010415 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094876 4905904 504 D169Q Transcriptional coactivator YAP1 Homo sapiens -0.0349406119979198 0.0730873321996528 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093943 4905905 504 D169R Transcriptional coactivator YAP1 Homo sapiens -0.345813974613539 0.0472377516382171 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094877 4905905 504 D169R Transcriptional coactivator YAP1 Homo sapiens -0.290717713274755 0.0553285771006106 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093944 4905906 504 D169S Transcriptional coactivator YAP1 Homo sapiens -0.15595803781965 0.0466374260333166 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094878 4905906 504 D169S Transcriptional coactivator YAP1 Homo sapiens -0.0356316141418514 0.0662228318554185 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093945 4905907 504 D169T Transcriptional coactivator YAP1 Homo sapiens -0.172232916384994 0.0601812767072955 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094879 4905907 504 D169T Transcriptional coactivator YAP1 Homo sapiens -0.266548230080397 0.0882306973379249 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093946 4905908 504 D169V Transcriptional coactivator YAP1 Homo sapiens -0.273434929515388 0.0501382363905734 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094880 4905908 504 D169V Transcriptional coactivator YAP1 Homo sapiens -0.327386893712726 0.0530448398201219 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093947 4905909 504 D169W Transcriptional coactivator YAP1 Homo sapiens -0.282359207905243 0.0627938073543161 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094881 4905909 504 D169W Transcriptional coactivator YAP1 Homo sapiens -0.43953051755157 0.0571794210277303 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093948 4905910 504 D169Y Transcriptional coactivator YAP1 Homo sapiens -0.407147539120444 0.0914639908122719 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094882 4905910 504 D169Y Transcriptional coactivator YAP1 Homo sapiens -0.379936366498466 0.0898489889230053 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093093 4905628 504 D170A Transcriptional coactivator YAP1 Homo sapiens -0.137232717463365 0.0556037731205057 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094047 4905628 504 D170A Transcriptional coactivator YAP1 Homo sapiens -0.319955962964907 0.0660420373457601 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093094 4905629 504 D170C Transcriptional coactivator YAP1 Homo sapiens -0.149108549001823 0.0336403306371898 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094048 4905629 504 D170C Transcriptional coactivator YAP1 Homo sapiens -0.387212796254102 0.103393339664212 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093915 4905877 504 D170E Transcriptional coactivator YAP1 Homo sapiens -0.0172335894406395 0.0568852548251331 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094849 4905877 504 D170E Transcriptional coactivator YAP1 Homo sapiens -0.168265754888747 0.0568538349919127 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093916 4905878 504 D170F Transcriptional coactivator YAP1 Homo sapiens -0.333827187883008 0.0778884417628323 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094850 4905878 504 D170F Transcriptional coactivator YAP1 Homo sapiens -0.390629536085789 0.0927533240879609 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093917 4905879 504 D170G Transcriptional coactivator YAP1 Homo sapiens -0.140764428479016 0.0362535719775976 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094851 4905879 504 D170G Transcriptional coactivator YAP1 Homo sapiens -0.224949901015715 0.0424015853927958 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093918 4905880 504 D170H Transcriptional coactivator YAP1 Homo sapiens -0.092590294791411 0.0711264262474094 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094852 4905880 504 D170H Transcriptional coactivator YAP1 Homo sapiens -0.528684393753787 0.122282574270727 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093919 4905881 504 D170I Transcriptional coactivator YAP1 Homo sapiens -0.191431790600256 0.0768264627872023 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094853 4905881 504 D170I Transcriptional coactivator YAP1 Homo sapiens -0.109037303431816 0.099443642281514 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093920 4905882 504 D170K Transcriptional coactivator YAP1 Homo sapiens -0.149284771953939 0.0774302620873317 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094854 4905882 504 D170K Transcriptional coactivator YAP1 Homo sapiens -0.081658026688877 0.0658120647450582 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093921 4905883 504 D170L Transcriptional coactivator YAP1 Homo sapiens -0.335060023350484 0.0470483155906795 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094855 4905883 504 D170L Transcriptional coactivator YAP1 Homo sapiens -0.333122565867432 0.0541661697504882 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093922 4905884 504 D170M Transcriptional coactivator YAP1 Homo sapiens -0.228330556141797 0.0677391962965739 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094856 4905884 504 D170M Transcriptional coactivator YAP1 Homo sapiens -0.274777888434586 0.0734915152998417 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093923 4905885 504 D170N Transcriptional coactivator YAP1 Homo sapiens -0.0434792061485248 0.0506686312165747 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094857 4905885 504 D170N Transcriptional coactivator YAP1 Homo sapiens 0.0407358166450262 0.0374862638961639 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093924 4905886 504 D170P Transcriptional coactivator YAP1 Homo sapiens -0.535137616564412 0.0845032567234386 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094858 4905886 504 D170P Transcriptional coactivator YAP1 Homo sapiens -0.708176275780869 0.11818794361784 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093925 4905887 504 D170Q Transcriptional coactivator YAP1 Homo sapiens -0.147926477347714 0.0761352046886154 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094859 4905887 504 D170Q Transcriptional coactivator YAP1 Homo sapiens -0.0910471512045752 0.0820121741466438 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093926 4905888 504 D170R Transcriptional coactivator YAP1 Homo sapiens -0.259260947626089 0.0374820997729103 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094860 4905888 504 D170R Transcriptional coactivator YAP1 Homo sapiens -0.193902997508831 0.0505205841831346 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093927 4905889 504 D170S Transcriptional coactivator YAP1 Homo sapiens -0.0935823647440618 0.0429891540502032 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094861 4905889 504 D170S Transcriptional coactivator YAP1 Homo sapiens 0.0263530499691823 0.046489313111445 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093928 4905890 504 D170T Transcriptional coactivator YAP1 Homo sapiens -0.218133556431107 0.0688325908207045 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094862 4905890 504 D170T Transcriptional coactivator YAP1 Homo sapiens 0.0630293176086287 0.0717465754243812 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093929 4905891 504 D170V Transcriptional coactivator YAP1 Homo sapiens -0.299247603414989 0.0447035132953546 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094863 4905891 504 D170V Transcriptional coactivator YAP1 Homo sapiens -0.329107666231152 0.0463607300150619 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093930 4905892 504 D170W Transcriptional coactivator YAP1 Homo sapiens -0.518768462345673 0.0680810398157848 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094864 4905892 504 D170W Transcriptional coactivator YAP1 Homo sapiens -0.464345644800412 0.0822300347200229 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093931 4905893 504 D170Y Transcriptional coactivator YAP1 Homo sapiens -0.192120728067375 0.0588409597429761 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094865 4905893 504 D170Y Transcriptional coactivator YAP1 Homo sapiens -0.231405632840405 0.0738589866963838 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093095 4905630 503 171V Transcriptional coactivator YAP1 Homo sapiens -1.36981875331587 0.363118560873158 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094049 4905630 503 171V Transcriptional coactivator YAP1 Homo sapiens -0.967424688340758 0.176186269514543 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093096 4905631 504 V171A Transcriptional coactivator YAP1 Homo sapiens -0.0905394367313988 0.0529000126488919 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094050 4905631 504 V171A Transcriptional coactivator YAP1 Homo sapiens -0.117126635196775 0.0617272215174099 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093097 4905632 504 V171C Transcriptional coactivator YAP1 Homo sapiens -0.191967711429941 0.0624522104021986 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094051 4905632 504 V171C Transcriptional coactivator YAP1 Homo sapiens -0.136724873438971 0.0509505009118836 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093098 4905633 504 V171D Transcriptional coactivator YAP1 Homo sapiens -0.106567023005914 0.0489769851519182 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094052 4905633 504 V171D Transcriptional coactivator YAP1 Homo sapiens -0.147115419523259 0.0795928870507208 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093099 4905634 504 V171E Transcriptional coactivator YAP1 Homo sapiens 0.00333445734085412 0.065377815990198 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094053 4905634 504 V171E Transcriptional coactivator YAP1 Homo sapiens -0.37872799864677 0.0910531753258301 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093100 4905635 504 V171F Transcriptional coactivator YAP1 Homo sapiens -0.267302660860698 0.0811521923636402 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094054 4905635 504 V171F Transcriptional coactivator YAP1 Homo sapiens -0.255227134442281 0.0801600757848628 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093101 4905636 504 V171G Transcriptional coactivator YAP1 Homo sapiens -0.212384917166003 0.036167737621168 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094055 4905636 504 V171G Transcriptional coactivator YAP1 Homo sapiens -0.215358082537796 0.0368992522594929 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093102 4905637 504 V171H Transcriptional coactivator YAP1 Homo sapiens -0.0629152198919424 0.042062069030635 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094056 4905637 504 V171H Transcriptional coactivator YAP1 Homo sapiens -0.261408591569841 0.126764733100333 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093103 4905638 504 V171I Transcriptional coactivator YAP1 Homo sapiens -0.0780007748298394 0.0462413957693235 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094057 4905638 504 V171I Transcriptional coactivator YAP1 Homo sapiens -0.0347372093155523 0.0503140773065204 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093104 4905639 504 V171K Transcriptional coactivator YAP1 Homo sapiens -0.186506975506359 0.0709764916986444 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094058 4905639 504 V171K Transcriptional coactivator YAP1 Homo sapiens -0.0889833581346996 0.0741767059385628 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093105 4905640 504 V171L Transcriptional coactivator YAP1 Homo sapiens -0.220218498765808 0.0669213042395573 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094059 4905640 504 V171L Transcriptional coactivator YAP1 Homo sapiens -0.191124814530152 0.0601059249589035 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093106 4905641 504 V171M Transcriptional coactivator YAP1 Homo sapiens -0.0173626745660576 0.0534662104672634 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094060 4905641 504 V171M Transcriptional coactivator YAP1 Homo sapiens -0.011788850935547 0.0469198109907151 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093107 4905642 504 V171N Transcriptional coactivator YAP1 Homo sapiens -0.0733631378801303 0.0711759282174152 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094061 4905642 504 V171N Transcriptional coactivator YAP1 Homo sapiens -0.114028110711371 0.0818546965298422 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093108 4905643 504 V171P Transcriptional coactivator YAP1 Homo sapiens -0.245126126392816 0.0585991644479375 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094062 4905643 504 V171P Transcriptional coactivator YAP1 Homo sapiens -0.555050200685626 0.111366583068991 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093109 4905644 504 V171Q Transcriptional coactivator YAP1 Homo sapiens -0.0456497217686154 0.048443762056315 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094063 4905644 504 V171Q Transcriptional coactivator YAP1 Homo sapiens -0.146507337636599 0.0864436594856956 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093110 4905645 504 V171R Transcriptional coactivator YAP1 Homo sapiens -0.168699029777342 0.043851130853142 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094064 4905645 504 V171R Transcriptional coactivator YAP1 Homo sapiens -0.226016524837886 0.0426963917126022 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093111 4905646 504 V171S Transcriptional coactivator YAP1 Homo sapiens -0.0592217898708528 0.0421278951926248 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094065 4905646 504 V171S Transcriptional coactivator YAP1 Homo sapiens -0.0416224255497014 0.043793887384404 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093112 4905647 504 V171T Transcriptional coactivator YAP1 Homo sapiens 0.0398437919141395 0.0677378184216396 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094066 4905647 504 V171T Transcriptional coactivator YAP1 Homo sapiens -0.159539283711076 0.0539787770562554 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093913 4905875 504 V171W Transcriptional coactivator YAP1 Homo sapiens -0.486945352943462 0.0690125702950093 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094847 4905875 504 V171W Transcriptional coactivator YAP1 Homo sapiens -0.105849480207812 0.0360646138032427 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093914 4905876 504 V171Y Transcriptional coactivator YAP1 Homo sapiens -0.0891920200851814 0.0774689876249571 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094848 4905876 504 V171Y Transcriptional coactivator YAP1 Homo sapiens -0.363082292667863 0.0956064187862434 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093113 4905648 503 172P Transcriptional coactivator YAP1 Homo sapiens -1.36199074123159 0.115503847309643 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094067 4905648 503 172P Transcriptional coactivator YAP1 Homo sapiens -1.13803428706571 0.165640301101881 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093114 4905649 504 P172A Transcriptional coactivator YAP1 Homo sapiens -0.138464102536173 0.0438599057408811 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094068 4905649 504 P172A Transcriptional coactivator YAP1 Homo sapiens -0.134155054183693 0.0663402455222751 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093115 4905650 504 P172C Transcriptional coactivator YAP1 Homo sapiens -0.201625164324277 0.0999388644143652 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094069 4905650 504 P172C Transcriptional coactivator YAP1 Homo sapiens -0.0904291472358489 0.0722454435362924 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093116 4905651 504 P172D Transcriptional coactivator YAP1 Homo sapiens -0.707139847677521 0.231416850955022 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094070 4905651 504 P172D Transcriptional coactivator YAP1 Homo sapiens -0.220151156896165 0.0975150730158046 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093117 4905652 504 P172E Transcriptional coactivator YAP1 Homo sapiens -0.306053580392788 0.083060766706759 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094071 4905652 504 P172E Transcriptional coactivator YAP1 Homo sapiens -0.420696988348658 0.0921477935938325 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093118 4905653 504 P172F Transcriptional coactivator YAP1 Homo sapiens -0.0753255218654176 0.562620710002709 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094072 4905653 504 P172F Transcriptional coactivator YAP1 Homo sapiens -1.06580950272172 0.498887318227235 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093119 4905654 504 P172G Transcriptional coactivator YAP1 Homo sapiens -0.33932780965995 0.0525199367262425 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094073 4905654 504 P172G Transcriptional coactivator YAP1 Homo sapiens -0.225261737880668 0.0421680408425499 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093120 4905655 504 P172H Transcriptional coactivator YAP1 Homo sapiens 0.00450202504828673 0.119229693651554 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094074 4905655 504 P172H Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093121 4905656 504 P172I Transcriptional coactivator YAP1 Homo sapiens -0.315930042881934 0.110496794838092 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094075 4905656 504 P172I Transcriptional coactivator YAP1 Homo sapiens -0.685590640372417 0.167824009620734 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093122 4905657 504 P172K Transcriptional coactivator YAP1 Homo sapiens -0.270866280559036 0.065545554133508 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094076 4905657 504 P172K Transcriptional coactivator YAP1 Homo sapiens -0.357812249650145 0.0787750948723796 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093123 4905658 504 P172L Transcriptional coactivator YAP1 Homo sapiens -0.408822744961543 0.0552590360639329 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094077 4905658 504 P172L Transcriptional coactivator YAP1 Homo sapiens -0.393351730172805 0.0382615612144536 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093124 4905659 504 P172M Transcriptional coactivator YAP1 Homo sapiens -0.240907653502048 0.105122357397233 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094078 4905659 504 P172M Transcriptional coactivator YAP1 Homo sapiens -0.504115405012214 0.117543929619695 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093125 4905660 504 P172N Transcriptional coactivator YAP1 Homo sapiens -0.0710512087799468 0.322552109815878 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094079 4905660 504 P172N Transcriptional coactivator YAP1 Homo sapiens -0.498570307705204 0.108568343310135 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093906 4905868 504 P172Q Transcriptional coactivator YAP1 Homo sapiens -0.630804923643175 0.158016002813534 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094840 4905868 504 P172Q Transcriptional coactivator YAP1 Homo sapiens -0.426104523075016 0.108017809499462 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093907 4905869 504 P172R Transcriptional coactivator YAP1 Homo sapiens -0.3515466595373 0.0385646163370338 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094841 4905869 504 P172R Transcriptional coactivator YAP1 Homo sapiens -0.225036364873725 0.0591911727771661 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093908 4905870 504 P172S Transcriptional coactivator YAP1 Homo sapiens -0.243614815149158 0.0715274676249792 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094842 4905870 504 P172S Transcriptional coactivator YAP1 Homo sapiens -0.466171307900686 0.0699758877459576 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093909 4905871 504 P172T Transcriptional coactivator YAP1 Homo sapiens -0.389356272930105 0.0836192411735254 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094843 4905871 504 P172T Transcriptional coactivator YAP1 Homo sapiens -0.138527148774374 0.0726291446242151 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093910 4905872 504 P172V Transcriptional coactivator YAP1 Homo sapiens -0.16199313003161 0.0647731537052413 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094844 4905872 504 P172V Transcriptional coactivator YAP1 Homo sapiens -0.332031136840094 0.0561049658479278 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093911 4905873 504 P172W Transcriptional coactivator YAP1 Homo sapiens -0.617961026183815 0.0982959298546207 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094845 4905873 504 P172W Transcriptional coactivator YAP1 Homo sapiens -0.823865413902223 0.0584972223574204 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093912 4905874 504 P172Y Transcriptional coactivator YAP1 Homo sapiens -0.497057504566096 0.0842111472373803 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094846 4905874 504 P172Y Transcriptional coactivator YAP1 Homo sapiens -0.722257127673826 0.169849248314579 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3829548 3776332 504 L173A Transcriptional coactivator YAP1 Homo sapiens 0.517897715533365 0.0676826207296087 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093127 3776332 504 L173A Transcriptional coactivator YAP1 Homo sapiens -0.525134969739183 0.0401383743231062 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094081 3776332 504 L173A Transcriptional coactivator YAP1 Homo sapiens -0.520787904740996 0.0480665060151648 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3829549 3776333 504 L173C Transcriptional coactivator YAP1 Homo sapiens 0.152278083255584 0.0722324048741152 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093128 3776333 504 L173C Transcriptional coactivator YAP1 Homo sapiens -0.129994522874617 0.0700796111480293 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094082 3776333 504 L173C Transcriptional coactivator YAP1 Homo sapiens -0.16250669496917 0.0654245294811369 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3829550 3776334 504 L173D Transcriptional coactivator YAP1 Homo sapiens 0.697723096151041 0.0925604531191808 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093129 3776334 504 L173D Transcriptional coactivator YAP1 Homo sapiens -0.79578825984128 0.0822959735985239 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094083 3776334 504 L173D Transcriptional coactivator YAP1 Homo sapiens -0.670488168386663 0.037946272882381 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3829551 3776335 504 L173E Transcriptional coactivator YAP1 Homo sapiens 0.547614250119055 0.0346656684467263 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093130 3776335 504 L173E Transcriptional coactivator YAP1 Homo sapiens -0.619917028432565 0.0583154890068714 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094084 3776335 504 L173E Transcriptional coactivator YAP1 Homo sapiens -0.572644249222361 0.0522663957843766 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3829552 3776336 504 L173F Transcriptional coactivator YAP1 Homo sapiens -0.0496444746750835 0.133520938018987 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093131 3776336 504 L173F Transcriptional coactivator YAP1 Homo sapiens -0.21696308793434 0.085026704158982 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094085 3776336 504 L173F Transcriptional coactivator YAP1 Homo sapiens -0.0801612097370991 0.0370392740990586 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3829553 3776337 504 L173G Transcriptional coactivator YAP1 Homo sapiens 0.673237394802775 0.0717065837426067 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093132 3776337 504 L173G Transcriptional coactivator YAP1 Homo sapiens -0.695027529288509 0.0379697949798969 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094086 3776337 504 L173G Transcriptional coactivator YAP1 Homo sapiens -0.723022687177288 0.0311179881376902 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3829554 3776338 504 L173H Transcriptional coactivator YAP1 Homo sapiens 0.502862706038798 0.0670349474600961 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093133 3776338 504 L173H Transcriptional coactivator YAP1 Homo sapiens -0.64748845090612 0.124400785760014 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094087 3776338 504 L173H Transcriptional coactivator YAP1 Homo sapiens -0.609505421948322 0.0342755490113912 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3829555 3776339 504 L173I Transcriptional coactivator YAP1 Homo sapiens 0.157296958634056 0.0595687555094161 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093134 3776339 504 L173I Transcriptional coactivator YAP1 Homo sapiens -0.268286028445343 0.0835772522478978 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094088 3776339 504 L173I Transcriptional coactivator YAP1 Homo sapiens -0.323887233623767 0.0729399892809621 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3829556 3776340 504 L173K Transcriptional coactivator YAP1 Homo sapiens 0.492886958244417 0.100884784076213 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093135 3776340 504 L173K Transcriptional coactivator YAP1 Homo sapiens -0.651577113474136 0.0628559567658235 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094089 3776340 504 L173K Transcriptional coactivator YAP1 Homo sapiens -0.413186680944307 0.102579587190713 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3829557 3776341 504 L173M Transcriptional coactivator YAP1 Homo sapiens -0.093206116637493 0.111875336946998 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093896 3776341 504 L173M Transcriptional coactivator YAP1 Homo sapiens -0.0442435641383596 0.0425902012409548 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094830 3776341 504 L173M Transcriptional coactivator YAP1 Homo sapiens 0.0736005873305608 0.0796413635088182 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3829558 3776342 504 L173N Transcriptional coactivator YAP1 Homo sapiens 0.519018360004446 0.110449309318167 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093897 3776342 504 L173N Transcriptional coactivator YAP1 Homo sapiens -0.898733792401617 0.168168475407927 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094831 3776342 504 L173N Transcriptional coactivator YAP1 Homo sapiens -0.835016062344836 0.156706741897074 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3829559 3776343 504 L173P Transcriptional coactivator YAP1 Homo sapiens 0.50042148848759 0.0581755005535739 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093898 3776343 504 L173P Transcriptional coactivator YAP1 Homo sapiens -0.29302033390957 0.0677669423465654 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094832 3776343 504 L173P Transcriptional coactivator YAP1 Homo sapiens -0.195370756934556 0.076436460129256 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3829560 3776344 504 L173Q Transcriptional coactivator YAP1 Homo sapiens 0.387227630972329 0.158272295617738 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093899 3776344 504 L173Q Transcriptional coactivator YAP1 Homo sapiens -0.598802690499513 0.0988771755176687 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094833 3776344 504 L173Q Transcriptional coactivator YAP1 Homo sapiens -0.418224972473752 0.11622500142497 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3829561 3776345 504 L173R Transcriptional coactivator YAP1 Homo sapiens 0.715949896628008 0.0610729822648774 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093900 3776345 504 L173R Transcriptional coactivator YAP1 Homo sapiens -0.677466440731921 0.0340631061788539 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094834 3776345 504 L173R Transcriptional coactivator YAP1 Homo sapiens -0.717881347738378 0.038786014123694 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3829562 3776346 504 L173S Transcriptional coactivator YAP1 Homo sapiens 0.606874870034307 0.0578847584220655 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093901 3776346 504 L173S Transcriptional coactivator YAP1 Homo sapiens -0.615722269494613 0.0408921299279208 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094835 3776346 504 L173S Transcriptional coactivator YAP1 Homo sapiens -0.50028080378149 0.0618829485954469 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3829563 3776347 504 L173T Transcriptional coactivator YAP1 Homo sapiens 0.406784141808117 0.0782480200738001 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093902 3776347 504 L173T Transcriptional coactivator YAP1 Homo sapiens -0.466283030508573 0.0463908444358749 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094836 3776347 504 L173T Transcriptional coactivator YAP1 Homo sapiens -0.294345651710433 0.0804495879651665 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3829564 3776348 504 L173V Transcriptional coactivator YAP1 Homo sapiens 0.196634057436938 0.0682644830869163 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093903 3776348 504 L173V Transcriptional coactivator YAP1 Homo sapiens -0.23404656152688 0.0407019034152893 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094837 3776348 504 L173V Transcriptional coactivator YAP1 Homo sapiens -0.230865588087917 0.0482460390029605 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3829565 3776349 504 L173W Transcriptional coactivator YAP1 Homo sapiens 0.505438732209153 0.0546911276058396 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093904 3776349 504 L173W Transcriptional coactivator YAP1 Homo sapiens -0.589773258496256 0.0361887030760884 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094838 3776349 504 L173W Transcriptional coactivator YAP1 Homo sapiens -0.412340469088046 0.0795680109735393 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3829566 3776350 504 L173Y Transcriptional coactivator YAP1 Homo sapiens 0.327002893121249 0.0993461653689409 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093905 3776350 504 L173Y Transcriptional coactivator YAP1 Homo sapiens -0.232607044819269 0.0531860159733995 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094839 3776350 504 L173Y Transcriptional coactivator YAP1 Homo sapiens -0.334861056389549 0.059706391062883 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093126 4905661 503 173L Transcriptional coactivator YAP1 Homo sapiens -1.30724050361706 0.158098095151721 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094080 4905661 503 173L Transcriptional coactivator YAP1 Homo sapiens -0.887134349792762 0.200079280979314 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3830574 3777356 504 P174A Transcriptional coactivator YAP1 Homo sapiens 0.288315092493105 0.0713578817818298 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093137 3777356 504 P174A Transcriptional coactivator YAP1 Homo sapiens -0.759342670113636 0.046577075111197 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094091 3777356 504 P174A Transcriptional coactivator YAP1 Homo sapiens -0.741339984624671 0.0945539693670245 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3830575 3777357 504 P174C Transcriptional coactivator YAP1 Homo sapiens 0.419030177026425 0.0671175273042086 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093138 3777357 504 P174C Transcriptional coactivator YAP1 Homo sapiens -0.959472912653999 0.106936801126423 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094092 3777357 504 P174C Transcriptional coactivator YAP1 Homo sapiens -1.29778941149775 0.253183823384671 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3830576 3777358 504 P174D Transcriptional coactivator YAP1 Homo sapiens 0.328589932653912 0.103720299959215 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093139 3777358 504 P174D Transcriptional coactivator YAP1 Homo sapiens -0.510707168783051 0.069378047995329 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094093 3777358 504 P174D Transcriptional coactivator YAP1 Homo sapiens -0.749168153015231 0.0477820115735063 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3830577 3777359 504 P174E Transcriptional coactivator YAP1 Homo sapiens 0.318137493480208 0.0734507630884647 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093140 3777359 504 P174E Transcriptional coactivator YAP1 Homo sapiens -0.534653909942762 0.0816983384757318 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094094 3777359 504 P174E Transcriptional coactivator YAP1 Homo sapiens -0.502195623876335 0.0852642782880376 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3830578 3777360 504 P174F Transcriptional coactivator YAP1 Homo sapiens 0.532118010600985 0.0751104001007963 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093141 3777360 504 P174F Transcriptional coactivator YAP1 Homo sapiens -0.762924709824253 0.0680072944989097 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094095 3777360 504 P174F Transcriptional coactivator YAP1 Homo sapiens -0.0381482793860576 0.0962685760201668 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3830579 3777361 504 P174G Transcriptional coactivator YAP1 Homo sapiens 0.276883141544592 0.0817836900642089 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093142 3777361 504 P174G Transcriptional coactivator YAP1 Homo sapiens -0.492218262757588 0.0363296669338342 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094096 3777361 504 P174G Transcriptional coactivator YAP1 Homo sapiens -0.516327999724024 0.0430762869733321 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3830580 3777362 504 P174H Transcriptional coactivator YAP1 Homo sapiens 0.527153463771197 0.12267712624312 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093143 3777362 504 P174H Transcriptional coactivator YAP1 Homo sapiens -1.01738651905439 0.137079338227265 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094097 3777362 504 P174H Transcriptional coactivator YAP1 Homo sapiens -0.954550290755098 0.0944167611464448 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3830581 3777363 504 P174I Transcriptional coactivator YAP1 Homo sapiens 0.556988794232708 0.170459523670466 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093144 3777363 504 P174I Transcriptional coactivator YAP1 Homo sapiens -1.01537873771601 0.146572098807092 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094098 3777363 504 P174I Transcriptional coactivator YAP1 Homo sapiens -1.0423948773566 0.214774380624215 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3830582 3777364 504 P174K Transcriptional coactivator YAP1 Homo sapiens 0.322278121087519 0.145767828450572 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093145 3777364 504 P174K Transcriptional coactivator YAP1 Homo sapiens -0.695264741336397 0.0382347603297507 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094099 3777364 504 P174K Transcriptional coactivator YAP1 Homo sapiens -0.520886700329574 0.0972688636365207 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3830583 3777365 504 P174L Transcriptional coactivator YAP1 Homo sapiens 0.404711453662338 0.0854279406329038 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093146 3777365 504 P174L Transcriptional coactivator YAP1 Homo sapiens -0.727575836024529 0.0467919220733113 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094100 3777365 504 P174L Transcriptional coactivator YAP1 Homo sapiens -0.902138876654115 0.0517803980303462 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3830584 3777366 504 P174M Transcriptional coactivator YAP1 Homo sapiens 0.244138285493224 0.0832025474048827 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093147 3777366 504 P174M Transcriptional coactivator YAP1 Homo sapiens -0.857269256966148 0.114195881398385 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094101 3777366 504 P174M Transcriptional coactivator YAP1 Homo sapiens -1.09594003107773 0.209618228934219 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3830585 3777367 504 P174N Transcriptional coactivator YAP1 Homo sapiens 0.450955018579092 0.0494421897284038 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093148 3777367 504 P174N Transcriptional coactivator YAP1 Homo sapiens -0.986089685357328 0.0954069612359254 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094102 3777367 504 P174N Transcriptional coactivator YAP1 Homo sapiens -0.715728964650049 0.612398913695019 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3830586 3777368 504 P174Q Transcriptional coactivator YAP1 Homo sapiens 0.351231569121442 0.0853651837323212 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093889 3777368 504 P174Q Transcriptional coactivator YAP1 Homo sapiens -0.681936412058053 0.0616358702674764 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094823 3777368 504 P174Q Transcriptional coactivator YAP1 Homo sapiens -0.779012996279733 0.168350021714299 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3830587 3777369 504 P174R Transcriptional coactivator YAP1 Homo sapiens 0.487495761264801 0.0996200811792298 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093890 3777369 504 P174R Transcriptional coactivator YAP1 Homo sapiens -0.919475886543225 0.0696826236235555 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094824 3777369 504 P174R Transcriptional coactivator YAP1 Homo sapiens -0.673303275685033 0.0454743266392294 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3830588 3777370 504 P174S Transcriptional coactivator YAP1 Homo sapiens 0.426879256963338 0.0662915949546891 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093891 3777370 504 P174S Transcriptional coactivator YAP1 Homo sapiens -0.667293735131914 0.0489963624246776 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094825 3777370 504 P174S Transcriptional coactivator YAP1 Homo sapiens -0.641697758957793 0.0743584217844131 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3830589 3777371 504 P174T Transcriptional coactivator YAP1 Homo sapiens 0.436271456730033 0.0712107063285897 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093892 3777371 504 P174T Transcriptional coactivator YAP1 Homo sapiens -0.85415286646357 0.0784728057744157 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094826 3777371 504 P174T Transcriptional coactivator YAP1 Homo sapiens -1.05712697219321 0.183616987646317 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3830590 3777372 504 P174V Transcriptional coactivator YAP1 Homo sapiens 0.610105730760086 0.113562053837625 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093893 3777372 504 P174V Transcriptional coactivator YAP1 Homo sapiens -0.788782490998017 0.0397268538440629 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094827 3777372 504 P174V Transcriptional coactivator YAP1 Homo sapiens -0.915443113009308 0.0498458826025983 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3830591 3777373 504 P174W Transcriptional coactivator YAP1 Homo sapiens 0.664672546364471 0.100007402771135 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093894 3777373 504 P174W Transcriptional coactivator YAP1 Homo sapiens -0.996953649055921 0.0550566842518801 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094828 3777373 504 P174W Transcriptional coactivator YAP1 Homo sapiens -1.00651521116308 0.143775363211545 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3830592 3777374 504 P174Y Transcriptional coactivator YAP1 Homo sapiens 0.480086508513861 0.112578002680765 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093895 3777374 504 P174Y Transcriptional coactivator YAP1 Homo sapiens -1.16025496255799 0.211559860159328 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094829 3777374 504 P174Y Transcriptional coactivator YAP1 Homo sapiens -0.957771423826041 0.127973526184118 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093136 4905662 503 174P Transcriptional coactivator YAP1 Homo sapiens -1.29806017980456 0.151667407794169 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094090 4905662 503 174P Transcriptional coactivator YAP1 Homo sapiens -1.41250994179335 0.200444413599369 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3831656 3778436 504 A175C Transcriptional coactivator YAP1 Homo sapiens 0.073757189381356 0.0891793561768556 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093870 3778436 504 A175C Transcriptional coactivator YAP1 Homo sapiens -0.288200672429075 0.0629521759480733 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094804 3778436 504 A175C Transcriptional coactivator YAP1 Homo sapiens -0.418363881622686 0.141142538735144 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3831657 3778437 504 A175D Transcriptional coactivator YAP1 Homo sapiens -0.20482000138243 0.0808191456470228 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093871 3778437 504 A175D Transcriptional coactivator YAP1 Homo sapiens 0.00476237089112424 0.0714117623903699 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094805 3778437 504 A175D Transcriptional coactivator YAP1 Homo sapiens -0.130270559054576 0.0822170651413214 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3831658 3778438 504 A175E Transcriptional coactivator YAP1 Homo sapiens -0.193464186921157 0.063465577565462 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093872 3778438 504 A175E Transcriptional coactivator YAP1 Homo sapiens -0.0101404343186528 0.0526098321877415 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094806 3778438 504 A175E Transcriptional coactivator YAP1 Homo sapiens 0.0482567548515926 0.0533794195146128 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3831659 3778439 504 A175F Transcriptional coactivator YAP1 Homo sapiens 0.00766470439405678 0.0828119444946688 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093873 3778439 504 A175F Transcriptional coactivator YAP1 Homo sapiens -0.223517421437306 0.0799880330836764 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094807 3778439 504 A175F Transcriptional coactivator YAP1 Homo sapiens -0.101028057043538 0.0604303841296864 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3831660 3778440 504 A175G Transcriptional coactivator YAP1 Homo sapiens -0.018334276029677 0.0814105942699941 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093874 3778440 504 A175G Transcriptional coactivator YAP1 Homo sapiens -0.0600702707514095 0.0348073399426755 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094808 3778440 504 A175G Transcriptional coactivator YAP1 Homo sapiens -0.181154539493404 0.0540316830152754 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3831661 3778441 504 A175H Transcriptional coactivator YAP1 Homo sapiens -0.140921773670836 0.100942420949942 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093875 3778441 504 A175H Transcriptional coactivator YAP1 Homo sapiens -0.206736355132964 0.0900326688345329 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094809 3778441 504 A175H Transcriptional coactivator YAP1 Homo sapiens 0.0382935670163202 0.0486068342557119 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3831662 3778442 504 A175I Transcriptional coactivator YAP1 Homo sapiens 0.00783106869519325 0.0767220045095531 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093876 3778442 504 A175I Transcriptional coactivator YAP1 Homo sapiens -0.235154663052941 0.0691273255211112 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094810 3778442 504 A175I Transcriptional coactivator YAP1 Homo sapiens -0.360175122622317 0.12797877071321 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3831663 3778443 504 A175K Transcriptional coactivator YAP1 Homo sapiens -0.113343834917263 0.0899581291405671 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093877 3778443 504 A175K Transcriptional coactivator YAP1 Homo sapiens 0.0972250309517848 0.0645459203726656 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094811 3778443 504 A175K Transcriptional coactivator YAP1 Homo sapiens -0.0068384407044061 0.0824282637453128 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3831664 3778444 504 A175L Transcriptional coactivator YAP1 Homo sapiens -0.0239656236490795 0.0827743376161056 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093878 3778444 504 A175L Transcriptional coactivator YAP1 Homo sapiens -0.183461871901694 0.0419303586908686 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094812 3778444 504 A175L Transcriptional coactivator YAP1 Homo sapiens -0.12875815025955 0.0650724018757909 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3831665 3778445 504 A175M Transcriptional coactivator YAP1 Homo sapiens 0.0267210488087164 0.0910882709801422 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093879 3778445 504 A175M Transcriptional coactivator YAP1 Homo sapiens -0.0929064808289518 0.0626303551272488 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094813 3778445 504 A175M Transcriptional coactivator YAP1 Homo sapiens 0.0207173073552909 0.0736798931150797 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3831666 3778446 504 A175N Transcriptional coactivator YAP1 Homo sapiens -0.120170046016798 0.106190155902387 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093880 3778446 504 A175N Transcriptional coactivator YAP1 Homo sapiens -0.0885908314954537 0.0647185100861388 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094814 3778446 504 A175N Transcriptional coactivator YAP1 Homo sapiens -0.00375692550254508 0.0438497628808425 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3831667 3778447 504 A175P Transcriptional coactivator YAP1 Homo sapiens -0.167901085636316 0.0964776292512126 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093881 3778447 504 A175P Transcriptional coactivator YAP1 Homo sapiens 0.0303654627612547 0.0360016891876457 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094815 3778447 504 A175P Transcriptional coactivator YAP1 Homo sapiens 0.0642057930536814 0.0736053357555498 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3831668 3778448 504 A175Q Transcriptional coactivator YAP1 Homo sapiens -0.132859970684144 0.106734060293576 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093882 3778448 504 A175Q Transcriptional coactivator YAP1 Homo sapiens 0.0653272262241914 0.0535301366122386 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094816 3778448 504 A175Q Transcriptional coactivator YAP1 Homo sapiens 0.0370065312282384 0.0796176922558876 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3831669 3778449 504 A175R Transcriptional coactivator YAP1 Homo sapiens -0.0913938971985074 0.0687343305094633 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093883 3778449 504 A175R Transcriptional coactivator YAP1 Homo sapiens -0.0572093672695324 0.0467763883464211 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094817 3778449 504 A175R Transcriptional coactivator YAP1 Homo sapiens -0.0395947772073545 0.0361266693393685 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3831670 3778450 504 A175S Transcriptional coactivator YAP1 Homo sapiens -0.109478552226638 0.0856756374045774 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093884 3778450 504 A175S Transcriptional coactivator YAP1 Homo sapiens -0.0887119394501999 0.0547991449227245 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094818 3778450 504 A175S Transcriptional coactivator YAP1 Homo sapiens -0.0978898442298672 0.0643351557422269 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3831671 3778451 504 A175T Transcriptional coactivator YAP1 Homo sapiens -0.087619593446597 0.0819805083976014 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093885 3778451 504 A175T Transcriptional coactivator YAP1 Homo sapiens -0.0929775501676649 0.0615983993212385 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094819 3778451 504 A175T Transcriptional coactivator YAP1 Homo sapiens -0.287596509744627 0.0826181298728608 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3831672 3778452 504 A175V Transcriptional coactivator YAP1 Homo sapiens -0.0766325446996855 0.0567247325048722 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093886 3778452 504 A175V Transcriptional coactivator YAP1 Homo sapiens -0.0368762844241929 0.0440569708643704 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094820 3778452 504 A175V Transcriptional coactivator YAP1 Homo sapiens -0.0822724870568654 0.0544512595170707 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3831673 3778453 504 A175W Transcriptional coactivator YAP1 Homo sapiens 0.100626926020475 0.0923781745367732 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093887 3778453 504 A175W Transcriptional coactivator YAP1 Homo sapiens -0.317132420061389 0.0605146281657275 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094821 3778453 504 A175W Transcriptional coactivator YAP1 Homo sapiens -0.51169020595 0.103647911941238 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3831674 3778454 504 A175Y Transcriptional coactivator YAP1 Homo sapiens 0.0478233959017194 0.0732374323871478 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093888 3778454 504 A175Y Transcriptional coactivator YAP1 Homo sapiens -0.138014480189212 0.0647958306258695 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094822 3778454 504 A175Y Transcriptional coactivator YAP1 Homo sapiens -0.0384664947323401 0.0870250934948048 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093149 4905663 503 175A Transcriptional coactivator YAP1 Homo sapiens -1.16969536389032 0.137517067337952 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094103 4905663 503 175A Transcriptional coactivator YAP1 Homo sapiens -1.07862415519894 0.345814255399035 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3832891 3779670 504 G176A Transcriptional coactivator YAP1 Homo sapiens 0.250238026672603 0.0470429136367351 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093151 3779670 504 G176A Transcriptional coactivator YAP1 Homo sapiens -0.332186066316599 0.0519234981790513 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094105 3779670 504 G176A Transcriptional coactivator YAP1 Homo sapiens -0.444043647451627 0.0578498986361868 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3832892 3779671 504 G176C Transcriptional coactivator YAP1 Homo sapiens 0.282198730918861 0.0951311004481369 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093152 3779671 504 G176C Transcriptional coactivator YAP1 Homo sapiens -0.386638233322989 0.0544685492141609 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094106 3779671 504 G176C Transcriptional coactivator YAP1 Homo sapiens -0.49145702532755 0.0879102140871701 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3832893 3779672 504 G176D Transcriptional coactivator YAP1 Homo sapiens 0.117654616208222 0.0741478800634587 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093153 3779672 504 G176D Transcriptional coactivator YAP1 Homo sapiens -0.374136556485454 0.0729663824188032 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094107 3779672 504 G176D Transcriptional coactivator YAP1 Homo sapiens -0.302726976176213 0.0567488522764454 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3832894 3779673 504 G176E Transcriptional coactivator YAP1 Homo sapiens 0.196974859927712 0.0955934557522677 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093154 3779673 504 G176E Transcriptional coactivator YAP1 Homo sapiens -0.358646341435291 0.0416907172319113 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094108 3779673 504 G176E Transcriptional coactivator YAP1 Homo sapiens -0.448614183683643 0.0545177941645294 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3832895 3779674 504 G176F Transcriptional coactivator YAP1 Homo sapiens 0.145114006647712 0.123694588107084 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093155 3779674 504 G176F Transcriptional coactivator YAP1 Homo sapiens -0.243810618429286 0.0754639620364417 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094109 3779674 504 G176F Transcriptional coactivator YAP1 Homo sapiens -0.339311818916616 0.121470380981552 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3832896 3779675 504 G176H Transcriptional coactivator YAP1 Homo sapiens 0.0426093777327088 0.11027377679312 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093856 3779675 504 G176H Transcriptional coactivator YAP1 Homo sapiens -0.122675106184482 0.0743554253919811 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094790 3779675 504 G176H Transcriptional coactivator YAP1 Homo sapiens -0.545296652270021 0.133569863957801 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3832897 3779676 504 G176I Transcriptional coactivator YAP1 Homo sapiens 0.644689295356406 0.0654038014279663 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093857 3779676 504 G176I Transcriptional coactivator YAP1 Homo sapiens -0.937614304697258 0.135096068558764 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094791 3779676 504 G176I Transcriptional coactivator YAP1 Homo sapiens -0.768267027041412 0.139311843721821 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3832898 3779677 504 G176K Transcriptional coactivator YAP1 Homo sapiens 0.303171362412837 0.149907870911956 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093858 3779677 504 G176K Transcriptional coactivator YAP1 Homo sapiens -0.511006675281914 0.0754601910103059 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094792 3779677 504 G176K Transcriptional coactivator YAP1 Homo sapiens -0.601852378306239 0.0670792988922155 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3832899 3779678 504 G176L Transcriptional coactivator YAP1 Homo sapiens 0.380318025325507 0.0931555802845226 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093859 3779678 504 G176L Transcriptional coactivator YAP1 Homo sapiens -0.714314732539029 0.0603064385151376 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094793 3779678 504 G176L Transcriptional coactivator YAP1 Homo sapiens -0.846981242853111 0.0475886514556306 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3832900 3779679 504 G176M Transcriptional coactivator YAP1 Homo sapiens 0.284927390153498 0.0620174392975861 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093860 3779679 504 G176M Transcriptional coactivator YAP1 Homo sapiens -0.282380238627923 0.0821851634459178 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094794 3779679 504 G176M Transcriptional coactivator YAP1 Homo sapiens -0.467176981790162 0.0581406439895473 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3832901 3779680 504 G176N Transcriptional coactivator YAP1 Homo sapiens -0.0703468396438444 0.103460945280243 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093861 3779680 504 G176N Transcriptional coactivator YAP1 Homo sapiens -0.223988799704282 0.0794501542211902 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094795 3779680 504 G176N Transcriptional coactivator YAP1 Homo sapiens -0.20246929793314 0.103253792667146 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3832902 3779681 504 G176P Transcriptional coactivator YAP1 Homo sapiens 0.333205012332097 0.0992362141988508 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093862 3779681 504 G176P Transcriptional coactivator YAP1 Homo sapiens -0.631817081561972 0.0769319064795381 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094796 3779681 504 G176P Transcriptional coactivator YAP1 Homo sapiens -0.443777168676122 0.0714303444945122 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3832903 3779682 504 G176Q Transcriptional coactivator YAP1 Homo sapiens 0.168877750451138 0.0594137593558166 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093863 3779682 504 G176Q Transcriptional coactivator YAP1 Homo sapiens -0.456250650592658 0.0671843623204232 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094797 3779682 504 G176Q Transcriptional coactivator YAP1 Homo sapiens -0.460089780313941 0.0718200697036896 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3832904 3779683 504 G176R Transcriptional coactivator YAP1 Homo sapiens 0.294948272953839 0.0538236735264546 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093864 3779683 504 G176R Transcriptional coactivator YAP1 Homo sapiens -0.538290774571814 0.0363917220696882 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094798 3779683 504 G176R Transcriptional coactivator YAP1 Homo sapiens -0.499268326178597 0.043097626536977 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3832905 3779684 504 G176S Transcriptional coactivator YAP1 Homo sapiens 0.209073787209618 0.0788672282445654 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093865 3779684 504 G176S Transcriptional coactivator YAP1 Homo sapiens -0.334936014606403 0.0549588406276026 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094799 3779684 504 G176S Transcriptional coactivator YAP1 Homo sapiens -0.358243151499899 0.0400615686453844 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3832906 3779685 504 G176T Transcriptional coactivator YAP1 Homo sapiens 0.369949171996796 0.136136967915641 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093866 3779685 504 G176T Transcriptional coactivator YAP1 Homo sapiens -0.549250681877671 0.0658669470879056 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094800 3779685 504 G176T Transcriptional coactivator YAP1 Homo sapiens -0.855471568477595 0.101125080831748 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3832907 3779686 504 G176V Transcriptional coactivator YAP1 Homo sapiens 0.66548061038291 0.0986586582905038 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093867 3779686 504 G176V Transcriptional coactivator YAP1 Homo sapiens -0.67171359532228 0.0424635382746317 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094801 3779686 504 G176V Transcriptional coactivator YAP1 Homo sapiens -0.79991031855252 0.0478500699692825 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3832908 3779687 504 G176W Transcriptional coactivator YAP1 Homo sapiens 0.37698602437695 0.0893589734705797 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093868 3779687 504 G176W Transcriptional coactivator YAP1 Homo sapiens -0.49821201872152 0.0658010991699957 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094802 3779687 504 G176W Transcriptional coactivator YAP1 Homo sapiens -0.661728670850112 0.0731842142438327 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3832909 3779688 504 G176Y Transcriptional coactivator YAP1 Homo sapiens 0.262761015958894 0.0839245544620711 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093869 3779688 504 G176Y Transcriptional coactivator YAP1 Homo sapiens -0.437528956223042 0.0398351403099473 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094803 3779688 504 G176Y Transcriptional coactivator YAP1 Homo sapiens -0.597239531481411 0.0680101248469009 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093150 4905664 503 176G Transcriptional coactivator YAP1 Homo sapiens -1.29315067362638 0.157755294372029 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094104 4905664 503 176G Transcriptional coactivator YAP1 Homo sapiens -1.15339668216561 0.198067578840288 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3834163 3780941 504 W177A Transcriptional coactivator YAP1 Homo sapiens 0.49650018932734 0.0682775914809433 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093157 3780941 504 W177A Transcriptional coactivator YAP1 Homo sapiens -0.500224441322841 0.0397669137447825 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094111 3780941 504 W177A Transcriptional coactivator YAP1 Homo sapiens -0.514115588039192 0.0558451348674065 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3834164 3780942 504 W177C Transcriptional coactivator YAP1 Homo sapiens 0.431261684871836 0.0702337995784325 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093158 3780942 504 W177C Transcriptional coactivator YAP1 Homo sapiens -0.450349719887454 0.0527258710131243 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094112 3780942 504 W177C Transcriptional coactivator YAP1 Homo sapiens -0.471447729399733 0.0856017708223352 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3834165 3780943 504 W177D Transcriptional coactivator YAP1 Homo sapiens 0.593718842878342 0.0704098216005525 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093159 3780943 504 W177D Transcriptional coactivator YAP1 Homo sapiens -0.554283551374306 0.051251943692024 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094113 3780943 504 W177D Transcriptional coactivator YAP1 Homo sapiens -0.239100207483139 0.0809187607028923 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3834166 3780944 504 W177E Transcriptional coactivator YAP1 Homo sapiens 0.442973245550612 0.0876159655418547 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093160 3780944 504 W177E Transcriptional coactivator YAP1 Homo sapiens -0.492609869317845 0.066780673972585 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094114 3780944 504 W177E Transcriptional coactivator YAP1 Homo sapiens -0.5742733842257 0.0500924959523664 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3834167 3780945 504 W177F Transcriptional coactivator YAP1 Homo sapiens 0.197412537827687 0.0709026832624884 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093161 3780945 504 W177F Transcriptional coactivator YAP1 Homo sapiens -0.190723998002458 0.0489143861180638 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094115 3780945 504 W177F Transcriptional coactivator YAP1 Homo sapiens -0.414776340235423 0.0829326598743755 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3834168 3780946 504 W177G Transcriptional coactivator YAP1 Homo sapiens 0.594304360147127 0.0638215623424586 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093162 3780946 504 W177G Transcriptional coactivator YAP1 Homo sapiens -0.546223708206352 0.0438684775733667 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094116 3780946 504 W177G Transcriptional coactivator YAP1 Homo sapiens -0.775827937064304 0.0438434694459316 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3834169 3780947 504 W177H Transcriptional coactivator YAP1 Homo sapiens 0.536168424460408 0.0608877126865626 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093163 3780947 504 W177H Transcriptional coactivator YAP1 Homo sapiens -0.61807995854656 0.167511809222163 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094117 3780947 504 W177H Transcriptional coactivator YAP1 Homo sapiens -0.921006070064038 0.528847753747814 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3834170 3780948 504 W177I Transcriptional coactivator YAP1 Homo sapiens 0.334047228617573 0.0903478475802079 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093164 3780948 504 W177I Transcriptional coactivator YAP1 Homo sapiens -0.487574099031875 0.064215883066049 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094118 3780948 504 W177I Transcriptional coactivator YAP1 Homo sapiens -0.695253897841215 0.0898276564465619 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3834171 3780949 504 W177K Transcriptional coactivator YAP1 Homo sapiens 0.497979156908561 0.0841740741883609 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093165 3780949 504 W177K Transcriptional coactivator YAP1 Homo sapiens -0.421824082762073 0.08379394121124 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094119 3780949 504 W177K Transcriptional coactivator YAP1 Homo sapiens -0.500724320849872 0.0854044631332373 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3834172 3780950 504 W177L Transcriptional coactivator YAP1 Homo sapiens 0.54160893123711 0.0673632998460096 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093166 3780950 504 W177L Transcriptional coactivator YAP1 Homo sapiens -0.741909433846999 0.0471991058722985 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094120 3780950 504 W177L Transcriptional coactivator YAP1 Homo sapiens -0.91833058063475 0.0548980508725346 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3834173 3780951 504 W177M Transcriptional coactivator YAP1 Homo sapiens 0.491692157779999 0.062367533230499 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093167 3780951 504 W177M Transcriptional coactivator YAP1 Homo sapiens -0.925317133507857 0.0798152185590297 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094121 3780951 504 W177M Transcriptional coactivator YAP1 Homo sapiens -0.688242529420789 0.0550690650441558 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3834174 3780952 504 W177N Transcriptional coactivator YAP1 Homo sapiens 0.416526821478979 0.0839218425357594 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093168 3780952 504 W177N Transcriptional coactivator YAP1 Homo sapiens -0.330554372315528 0.0739505477205155 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094122 3780952 504 W177N Transcriptional coactivator YAP1 Homo sapiens -0.465408016301697 0.106090445058003 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3834175 3780953 504 W177P Transcriptional coactivator YAP1 Homo sapiens 0.615939646896887 0.0644939782824035 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093169 3780953 504 W177P Transcriptional coactivator YAP1 Homo sapiens -0.70116712243627 0.140557892278347 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094123 3780953 504 W177P Transcriptional coactivator YAP1 Homo sapiens -0.611560426888368 0.0487120933720368 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3834176 3780954 504 W177Q Transcriptional coactivator YAP1 Homo sapiens 0.479923995485671 0.0570106269274383 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093170 3780954 504 W177Q Transcriptional coactivator YAP1 Homo sapiens -0.712633580079792 0.0619969605239266 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094124 3780954 504 W177Q Transcriptional coactivator YAP1 Homo sapiens -0.435551762642819 0.0901984588277978 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3834177 3780955 504 W177R Transcriptional coactivator YAP1 Homo sapiens 0.661374236317893 0.0625463977114835 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093171 3780955 504 W177R Transcriptional coactivator YAP1 Homo sapiens -0.642025466870803 0.0440882921372176 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094125 3780955 504 W177R Transcriptional coactivator YAP1 Homo sapiens -0.644967935462951 0.0517966915065401 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3834178 3780956 504 W177S Transcriptional coactivator YAP1 Homo sapiens 0.50157766932088 0.0558214472397538 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093172 3780956 504 W177S Transcriptional coactivator YAP1 Homo sapiens -0.508902877816534 0.0369545549724308 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094126 3780956 504 W177S Transcriptional coactivator YAP1 Homo sapiens -0.583210983135348 0.0656715184525833 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3834179 3780957 504 W177T Transcriptional coactivator YAP1 Homo sapiens 0.473152878125647 0.0694139820038415 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093173 3780957 504 W177T Transcriptional coactivator YAP1 Homo sapiens -0.397570583130161 0.0587650968498864 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094127 3780957 504 W177T Transcriptional coactivator YAP1 Homo sapiens -0.601296032990356 0.0974163482992409 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3834180 3780958 504 W177V Transcriptional coactivator YAP1 Homo sapiens 0.265803763522213 0.0574385317651653 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093174 3780958 504 W177V Transcriptional coactivator YAP1 Homo sapiens -0.384092065483985 0.0398166332739885 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094128 3780958 504 W177V Transcriptional coactivator YAP1 Homo sapiens -0.404862054090337 0.0455607904972393 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3834181 3780959 504 W177Y Transcriptional coactivator YAP1 Homo sapiens 0.0796049284653816 0.13002585014912 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093855 3780959 504 W177Y Transcriptional coactivator YAP1 Homo sapiens -0.0354998598846233 0.0480810256019171 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094789 3780959 504 W177Y Transcriptional coactivator YAP1 Homo sapiens -0.0633524939959444 0.0360202337475986 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093156 4905665 503 177W Transcriptional coactivator YAP1 Homo sapiens -1.23013396236757 0.105432814375836 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094110 4905665 503 177W Transcriptional coactivator YAP1 Homo sapiens -1.15715975227183 0.111283450195675 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3835473 3782250 504 E178A Transcriptional coactivator YAP1 Homo sapiens 0.135305514939364 0.0410704360698965 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093176 3782250 504 E178A Transcriptional coactivator YAP1 Homo sapiens -0.134479868384226 0.0575907848072493 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094130 3782250 504 E178A Transcriptional coactivator YAP1 Homo sapiens -0.111105348822577 0.0617005665526578 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3835474 3782251 504 E178C Transcriptional coactivator YAP1 Homo sapiens 0.194936380313002 0.078556234437608 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093177 3782251 504 E178C Transcriptional coactivator YAP1 Homo sapiens -0.723575937610171 0.263630116522822 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094131 3782251 504 E178C Transcriptional coactivator YAP1 Homo sapiens -0.400186627276473 0.0670233100005533 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3835475 3782252 504 E178D Transcriptional coactivator YAP1 Homo sapiens 0.194921785423266 0.0634066207375577 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093178 3782252 504 E178D Transcriptional coactivator YAP1 Homo sapiens -0.0714072806708471 0.0720788569137942 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094132 3782252 504 E178D Transcriptional coactivator YAP1 Homo sapiens -0.0428541811662687 0.0631841304376753 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3835476 3782253 504 E178F Transcriptional coactivator YAP1 Homo sapiens 0.441735999500934 0.0814595315991932 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093839 3782253 504 E178F Transcriptional coactivator YAP1 Homo sapiens -1.00625169415162 0.180438596736777 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094773 3782253 504 E178F Transcriptional coactivator YAP1 Homo sapiens -0.550043234586706 0.0417958564570261 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3835477 3782254 504 E178G Transcriptional coactivator YAP1 Homo sapiens 0.267839688749899 0.0553486763381371 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093840 3782254 504 E178G Transcriptional coactivator YAP1 Homo sapiens -0.0458919376781076 0.0352381361668514 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094774 3782254 504 E178G Transcriptional coactivator YAP1 Homo sapiens -0.135600843284842 0.0322198070023925 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3835478 3782255 504 E178H Transcriptional coactivator YAP1 Homo sapiens 0.276849360620161 0.146261218994403 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093841 3782255 504 E178H Transcriptional coactivator YAP1 Homo sapiens -0.549516829299179 0.131941097558027 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094775 3782255 504 E178H Transcriptional coactivator YAP1 Homo sapiens -0.505073665523814 0.128836676451907 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3835479 3782256 504 E178I Transcriptional coactivator YAP1 Homo sapiens 0.276835947275084 0.0659139631542658 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093842 3782256 504 E178I Transcriptional coactivator YAP1 Homo sapiens -1.07204145123532 0.226948765141957 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094776 3782256 504 E178I Transcriptional coactivator YAP1 Homo sapiens -0.400331206186588 0.0897056148371413 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3835480 3782257 504 E178K Transcriptional coactivator YAP1 Homo sapiens 0.275781570580143 0.117369150517575 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093843 3782257 504 E178K Transcriptional coactivator YAP1 Homo sapiens -0.370679540795186 0.110053119109267 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094777 3782257 504 E178K Transcriptional coactivator YAP1 Homo sapiens -0.373577729334 0.0848053819924522 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3835481 3782258 504 E178L Transcriptional coactivator YAP1 Homo sapiens 0.343814619451011 0.10652622096172 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093844 3782258 504 E178L Transcriptional coactivator YAP1 Homo sapiens -0.477125455846353 0.0411818897746175 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094778 3782258 504 E178L Transcriptional coactivator YAP1 Homo sapiens -0.740872725431343 0.0824453439008705 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3835482 3782259 504 E178M Transcriptional coactivator YAP1 Homo sapiens 0.236002067698651 0.0740270586825092 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093845 3782259 504 E178M Transcriptional coactivator YAP1 Homo sapiens -0.422785694426703 0.0629985668215171 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094779 3782259 504 E178M Transcriptional coactivator YAP1 Homo sapiens -0.624295135732931 0.0940300834339022 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3835483 3782260 504 E178N Transcriptional coactivator YAP1 Homo sapiens 0.314120117860002 0.0789136978333489 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093846 3782260 504 E178N Transcriptional coactivator YAP1 Homo sapiens -0.427374743155047 0.110364156245738 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094780 3782260 504 E178N Transcriptional coactivator YAP1 Homo sapiens -0.424966318517934 0.0403097128306713 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3835484 3782261 504 E178P Transcriptional coactivator YAP1 Homo sapiens 1.06963049274821 0.0972634509727733 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093847 3782261 504 E178P Transcriptional coactivator YAP1 Homo sapiens -0.591928544972337 0.111213289803895 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094781 3782261 504 E178P Transcriptional coactivator YAP1 Homo sapiens -0.94823701168008 0.097686654163544 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3835485 3782262 504 E178Q Transcriptional coactivator YAP1 Homo sapiens -0.00913243886141613 0.0570530331278768 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093848 3782262 504 E178Q Transcriptional coactivator YAP1 Homo sapiens -0.110474386240477 0.0572379327925111 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094782 3782262 504 E178Q Transcriptional coactivator YAP1 Homo sapiens -0.217719538069673 0.0919662903640265 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3835486 3782263 504 E178R Transcriptional coactivator YAP1 Homo sapiens 0.33827765361894 0.0583250987360045 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093849 3782263 504 E178R Transcriptional coactivator YAP1 Homo sapiens -0.468980039393009 0.0373416000414581 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094783 3782263 504 E178R Transcriptional coactivator YAP1 Homo sapiens -0.629834421534731 0.0614810192253274 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3835487 3782264 504 E178S Transcriptional coactivator YAP1 Homo sapiens 0.0738249582818524 0.0618596400699441 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093850 3782264 504 E178S Transcriptional coactivator YAP1 Homo sapiens -0.033373581301895 0.0625217423225643 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094784 3782264 504 E178S Transcriptional coactivator YAP1 Homo sapiens -0.106021699203684 0.0503909167449256 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3835488 3782265 504 E178T Transcriptional coactivator YAP1 Homo sapiens 0.106266956305198 0.0749712760304444 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093851 3782265 504 E178T Transcriptional coactivator YAP1 Homo sapiens -0.0699242521232075 0.0415432193461879 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094785 3782265 504 E178T Transcriptional coactivator YAP1 Homo sapiens -0.061766378305566 0.0530684614626421 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3835489 3782266 504 E178V Transcriptional coactivator YAP1 Homo sapiens 0.139204719214498 0.0982927451625328 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093852 3782266 504 E178V Transcriptional coactivator YAP1 Homo sapiens -0.446075406801983 0.0354070781377356 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094786 3782266 504 E178V Transcriptional coactivator YAP1 Homo sapiens -0.56238269020494 0.0550913188567912 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3835490 3782267 504 E178W Transcriptional coactivator YAP1 Homo sapiens 0.72752268769983 0.0349523989527985 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093853 3782267 504 E178W Transcriptional coactivator YAP1 Homo sapiens -0.817043721175491 0.105786638155002 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094787 3782267 504 E178W Transcriptional coactivator YAP1 Homo sapiens -0.875742453011899 0.0649774050272036 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3835491 3782268 504 E178Y Transcriptional coactivator YAP1 Homo sapiens 0.441528452742041 0.142787770270998 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093854 3782268 504 E178Y Transcriptional coactivator YAP1 Homo sapiens -1.03049779677073 0.184230145957131 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094788 3782268 504 E178Y Transcriptional coactivator YAP1 Homo sapiens -0.666503389356657 0.0767594947725422 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093175 4905666 503 178E Transcriptional coactivator YAP1 Homo sapiens -1.10243215086379 0.0770810795711026 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094129 4905666 503 178E Transcriptional coactivator YAP1 Homo sapiens -1.0985525152859 0.0570763943798705 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3836784 3783560 504 M179A Transcriptional coactivator YAP1 Homo sapiens -0.0806499765839229 0.069905163621801 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093180 3783560 504 M179A Transcriptional coactivator YAP1 Homo sapiens -0.0879468562630312 0.0573646102627809 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094134 3783560 504 M179A Transcriptional coactivator YAP1 Homo sapiens -0.0564913742468143 0.0342311122581353 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3836785 3783561 504 M179C Transcriptional coactivator YAP1 Homo sapiens 0.047648413638899 0.0989253554255688 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093181 3783561 504 M179C Transcriptional coactivator YAP1 Homo sapiens -0.191926375181914 0.05230261684122 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094135 3783561 504 M179C Transcriptional coactivator YAP1 Homo sapiens -0.0781675799618379 0.0638117800876109 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3836786 3783562 504 M179D Transcriptional coactivator YAP1 Homo sapiens 0.322671260380267 0.0554615543631387 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093182 3783562 504 M179D Transcriptional coactivator YAP1 Homo sapiens -0.464227821264558 0.0559362688460838 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094136 3783562 504 M179D Transcriptional coactivator YAP1 Homo sapiens -0.358131882436722 0.0355138461149211 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3836787 3783563 504 M179E Transcriptional coactivator YAP1 Homo sapiens -0.251414361281928 0.118560152034595 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093183 3783563 504 M179E Transcriptional coactivator YAP1 Homo sapiens 0.0645476390903466 0.0425113215269564 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094137 3783563 504 M179E Transcriptional coactivator YAP1 Homo sapiens 0.0684056686484903 0.0601881364960277 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3836788 3783564 504 M179F Transcriptional coactivator YAP1 Homo sapiens 0.229034161262531 0.0931107423526486 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093184 3783564 504 M179F Transcriptional coactivator YAP1 Homo sapiens -0.49896404835668 0.115606027613977 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094138 3783564 504 M179F Transcriptional coactivator YAP1 Homo sapiens -0.34252657350623 0.069989778660851 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3836789 3783565 504 M179G Transcriptional coactivator YAP1 Homo sapiens 0.260909456709179 0.0581561322234174 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093185 3783565 504 M179G Transcriptional coactivator YAP1 Homo sapiens -0.338719369096885 0.0379216998927187 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094139 3783565 504 M179G Transcriptional coactivator YAP1 Homo sapiens -0.432179672180433 0.0369893376774571 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3836790 3783566 504 M179H Transcriptional coactivator YAP1 Homo sapiens 0.272482844179734 0.0605398771918686 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093186 3783566 504 M179H Transcriptional coactivator YAP1 Homo sapiens -0.456363781376732 0.0694991994619152 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094140 3783566 504 M179H Transcriptional coactivator YAP1 Homo sapiens -0.225364502302074 0.0755864920562128 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3836791 3783567 504 M179I Transcriptional coactivator YAP1 Homo sapiens -0.117877568058902 0.124394529536453 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093187 3783567 504 M179I Transcriptional coactivator YAP1 Homo sapiens -0.236187344056285 0.0713480320486748 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094141 3783567 504 M179I Transcriptional coactivator YAP1 Homo sapiens -0.170788089894134 0.0828761040065952 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3836792 3783568 504 M179K Transcriptional coactivator YAP1 Homo sapiens -0.0234776108213665 0.0822305457529797 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093188 3783568 504 M179K Transcriptional coactivator YAP1 Homo sapiens -0.223525398607978 0.0575753453560125 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094142 3783568 504 M179K Transcriptional coactivator YAP1 Homo sapiens -0.216597634075988 0.0755146987052587 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3836793 3783569 504 M179L Transcriptional coactivator YAP1 Homo sapiens -0.0266470165962486 0.107398515998363 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093189 3783569 504 M179L Transcriptional coactivator YAP1 Homo sapiens -0.0741013887659479 0.0368976124777801 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094143 3783569 504 M179L Transcriptional coactivator YAP1 Homo sapiens -0.064760012209122 0.0370710743720824 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3836794 3783570 504 M179N Transcriptional coactivator YAP1 Homo sapiens 0.38821815924448 0.18381293630126 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093830 3783570 504 M179N Transcriptional coactivator YAP1 Homo sapiens -0.57267745654904 0.0870011264200107 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094764 3783570 504 M179N Transcriptional coactivator YAP1 Homo sapiens -0.443672986814421 0.0746244044558157 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3836795 3783571 504 M179P Transcriptional coactivator YAP1 Homo sapiens 0.257529473794675 0.0689874848921792 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093831 3783571 504 M179P Transcriptional coactivator YAP1 Homo sapiens -0.724903193770509 0.13542030428671 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094765 3783571 504 M179P Transcriptional coactivator YAP1 Homo sapiens -0.434419936567066 0.107471528009674 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3836796 3783572 504 M179Q Transcriptional coactivator YAP1 Homo sapiens -0.100772757888646 0.0953864266224634 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093832 3783572 504 M179Q Transcriptional coactivator YAP1 Homo sapiens -0.13906891711257 0.084975287668015 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094766 3783572 504 M179Q Transcriptional coactivator YAP1 Homo sapiens -0.202245342366491 0.0764911733246525 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3836797 3783573 504 M179R Transcriptional coactivator YAP1 Homo sapiens 0.0273989786237348 0.0922874150277811 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093833 3783573 504 M179R Transcriptional coactivator YAP1 Homo sapiens -0.293594690197947 0.0464924445823415 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094767 3783573 504 M179R Transcriptional coactivator YAP1 Homo sapiens -0.48139461667161 0.0380139414820759 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3836798 3783574 504 M179S Transcriptional coactivator YAP1 Homo sapiens -0.00873109177177319 0.0674341700199148 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093834 3783574 504 M179S Transcriptional coactivator YAP1 Homo sapiens -0.149801112455611 0.0367549008944598 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094768 3783574 504 M179S Transcriptional coactivator YAP1 Homo sapiens -0.0671157979798181 0.0419033267802116 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3836799 3783575 504 M179T Transcriptional coactivator YAP1 Homo sapiens 0.069093940940641 0.0868311475706135 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093835 3783575 504 M179T Transcriptional coactivator YAP1 Homo sapiens -0.289721411238073 0.05988341640638 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094769 3783575 504 M179T Transcriptional coactivator YAP1 Homo sapiens -0.431836651628984 0.0969210946600825 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3836800 3783576 504 M179V Transcriptional coactivator YAP1 Homo sapiens -0.0721170748626268 0.101322259425675 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093836 3783576 504 M179V Transcriptional coactivator YAP1 Homo sapiens -0.144316445020013 0.0352793636352785 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094770 3783576 504 M179V Transcriptional coactivator YAP1 Homo sapiens -0.0478251442816907 0.0349154240838733 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3836801 3783577 504 M179W Transcriptional coactivator YAP1 Homo sapiens 0.301468610273271 0.0588022368517356 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093837 3783577 504 M179W Transcriptional coactivator YAP1 Homo sapiens -0.387337323552781 0.0399735587250515 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094771 3783577 504 M179W Transcriptional coactivator YAP1 Homo sapiens -0.375642939844171 0.044549588590612 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3836802 3783578 504 M179Y Transcriptional coactivator YAP1 Homo sapiens 0.169176658744158 0.0942402720395624 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093838 3783578 504 M179Y Transcriptional coactivator YAP1 Homo sapiens -0.325605625709615 0.0653374587585715 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094772 3783578 504 M179Y Transcriptional coactivator YAP1 Homo sapiens -0.616164981687469 0.13145851576602 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093179 4905667 503 179M Transcriptional coactivator YAP1 Homo sapiens -1.41747730795901 0.188097623338335 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094133 4905667 503 179M Transcriptional coactivator YAP1 Homo sapiens -1.2886252347569 0.153752796321785 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 374 199 504 A180R Transcriptional coactivator YAP1 Homo sapiens 29.9 11.4 yes 63.0 potassium phosphate 20 mM NaCl 100 mM Fluorescence Thermal 7.0 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 11420447 10.1110/ps.640101 2001 ProTherm 377 199 504 A180R Transcriptional coactivator YAP1 Homo sapiens 20.9 6.4 yes 59.3 potassium 20 mM NaCl 2 M Fluorescence Thermal 7.0 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 11420447 10.1110/ps.640101 2001 ProTherm HotMuSiC_S1626.csv 3838108 199 504 A180R Transcriptional coactivator YAP1 Homo sapiens -0.0846428773504859 0.0798235029744216 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093824 199 504 A180R Transcriptional coactivator YAP1 Homo sapiens -0.0512344664362793 0.0341652067114809 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094758 199 504 A180R Transcriptional coactivator YAP1 Homo sapiens -0.121036644251207 0.0356075956160485 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 15658 7302 504 A180R, D194T Transcriptional coactivator YAP1 Homo sapiens 34.7 16.4 yes 68.0 potassium phosphate 20 mM NaCl 100 mM Fluorescence Thermal 7.0 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0, 6.0 1K9Q 11420447 10.1110/ps.640101 2001 ProTherm 15661 7302 504 A180R, D194T Transcriptional coactivator YAP1 Homo sapiens 29.6 15.5 yes 68.4 potassium 20 mM NaCl 2 M Fluorescence Thermal 7.0 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0, 6.0 1K9Q 11420447 10.1110/ps.640101 2001 ProTherm 16740 7302 504 A180R, D194T Transcriptional coactivator YAP1 Homo sapiens -1.34 0.26 yes potassium phosphate 20 mM 65.0 NaCl 100 mM Fluorescence Thermal 7.0 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0, 6.0 1K9Q 11420447 10.1110/ps.640101 2001 ProTherm 16743 7302 504 A180R, D194T Transcriptional coactivator YAP1 Homo sapiens -1.24 0.25 yes potassium 20 mM 65.0 NaCl 2 M Fluorescence Thermal 7.0 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0, 6.0 1K9Q 11420447 10.1110/ps.640101 2001 ProTherm 15659 7303 504 A180R, L190Y Transcriptional coactivator YAP1 Homo sapiens 34.5 22.1 yes 73.7 potassium phosphate 20 mM NaCl 100 mM Fluorescence Thermal 7.0 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0, 8.0 1K9Q 11420447 10.1110/ps.640101 2001 ProTherm 15662 7303 504 A180R, L190Y Transcriptional coactivator YAP1 Homo sapiens 32.6 21.0 yes 73.9 potassium 20 mM NaCl 2 M Fluorescence Thermal 7.0 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0, 8.0 1K9Q 11420447 10.1110/ps.640101 2001 ProTherm 16741 7303 504 A180R, L190Y Transcriptional coactivator YAP1 Homo sapiens -1.86 0.78 yes potassium phosphate 20 mM 65.0 NaCl 100 mM Fluorescence Thermal 7.0 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0, 8.0 1K9Q 11420447 10.1110/ps.640101 2001 ProTherm 16744 7303 504 A180R, L190Y Transcriptional coactivator YAP1 Homo sapiens -1.75 0.76 yes potassium 20 mM 65.0 NaCl 2 M Fluorescence Thermal 7.0 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0, 8.0 1K9Q 11420447 10.1110/ps.640101 2001 ProTherm 15660 7304 504 A180R, L190Y, D194T Transcriptional coactivator YAP1 Homo sapiens 40.7 28.0 yes 79.6 potassium phosphate 20 mM NaCl 100 mM Fluorescence Thermal 7.0 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0, 8.0, 6.0 1K9Q 11420447 10.1110/ps.640101 2001 ProTherm 15663 7304 504 A180R, L190Y, D194T Transcriptional coactivator YAP1 Homo sapiens 34.7 25.3 yes 78.2 potassium 20 mM NaCl 2 M Fluorescence Thermal 7.0 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0, 8.0, 6.0 1K9Q 11420447 10.1110/ps.640101 2001 ProTherm 16742 7304 504 A180R, L190Y, D194T Transcriptional coactivator YAP1 Homo sapiens -2.54 1.46 yes potassium phosphate 20 mM 65.0 NaCl 100 mM Fluorescence Thermal 7.0 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0, 8.0, 6.0 1K9Q 11420447 10.1110/ps.640101 2001 ProTherm 16745 7304 504 A180R, L190Y, D194T Transcriptional coactivator YAP1 Homo sapiens -1.98 0.99 yes potassium 20 mM 65.0 NaCl 2 M Fluorescence Thermal 7.0 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0, 8.0, 6.0 1K9Q 11420447 10.1110/ps.640101 2001 ProTherm 3838095 3784870 504 A180C Transcriptional coactivator YAP1 Homo sapiens 0.019350608111891 0.0731706075970976 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093811 3784870 504 A180C Transcriptional coactivator YAP1 Homo sapiens -0.256134621920038 0.0614580083693864 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094745 3784870 504 A180C Transcriptional coactivator YAP1 Homo sapiens -0.238015156937129 0.0684388580130035 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3838096 3784871 504 A180D Transcriptional coactivator YAP1 Homo sapiens 0.136402945996385 0.0798002051643147 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093812 3784871 504 A180D Transcriptional coactivator YAP1 Homo sapiens -0.202117573313933 0.0503840927906813 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094746 3784871 504 A180D Transcriptional coactivator YAP1 Homo sapiens -0.306275537955357 0.0436269908768404 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3838097 3784872 504 A180E Transcriptional coactivator YAP1 Homo sapiens 0.188035022973178 0.04800191267099 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093813 3784872 504 A180E Transcriptional coactivator YAP1 Homo sapiens -0.378065675640031 0.0604328114025272 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094747 3784872 504 A180E Transcriptional coactivator YAP1 Homo sapiens -0.364139703128115 0.0530523735152911 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3838098 3784873 504 A180F Transcriptional coactivator YAP1 Homo sapiens 0.169317003743991 0.0543544098837431 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093814 3784873 504 A180F Transcriptional coactivator YAP1 Homo sapiens -0.338171119912525 0.0565216263780145 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094748 3784873 504 A180F Transcriptional coactivator YAP1 Homo sapiens -0.546220043750358 0.107583364048969 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3838099 3784874 504 A180G Transcriptional coactivator YAP1 Homo sapiens 0.105001263161263 0.0841626525899942 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093815 3784874 504 A180G Transcriptional coactivator YAP1 Homo sapiens -0.22906228025161 0.0411064474959814 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094749 3784874 504 A180G Transcriptional coactivator YAP1 Homo sapiens -0.340547826854069 0.0412166549163819 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3838100 3784875 504 A180H Transcriptional coactivator YAP1 Homo sapiens 0.128321533869483 0.0497845867418262 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093816 3784875 504 A180H Transcriptional coactivator YAP1 Homo sapiens -0.247101563930112 0.0516461029468959 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094750 3784875 504 A180H Transcriptional coactivator YAP1 Homo sapiens -0.313935385310857 0.0571962602184378 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3838101 3784876 504 A180I Transcriptional coactivator YAP1 Homo sapiens 0.174389239929808 0.145086212216219 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093817 3784876 504 A180I Transcriptional coactivator YAP1 Homo sapiens -0.46854419579539 0.0961484755097452 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094751 3784876 504 A180I Transcriptional coactivator YAP1 Homo sapiens -0.418098111567328 0.0853793035679967 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3838102 3784877 504 A180K Transcriptional coactivator YAP1 Homo sapiens -0.0793149053881941 0.0587729638014979 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093818 3784877 504 A180K Transcriptional coactivator YAP1 Homo sapiens -0.145949589415751 0.069184869929549 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094752 3784877 504 A180K Transcriptional coactivator YAP1 Homo sapiens -0.13948817329455 0.0707725104534893 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3838103 3784878 504 A180L Transcriptional coactivator YAP1 Homo sapiens 0.113003613071293 0.0631726951502005 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093819 3784878 504 A180L Transcriptional coactivator YAP1 Homo sapiens -0.332687177674261 0.0573927986831461 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094753 3784878 504 A180L Transcriptional coactivator YAP1 Homo sapiens -0.237385813446041 0.0480606094635366 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3838104 3784879 504 A180M Transcriptional coactivator YAP1 Homo sapiens 6.23834649536199E-4 0.0748660341597794 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093820 3784879 504 A180M Transcriptional coactivator YAP1 Homo sapiens -0.32921638323465 0.0745422362251704 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094754 3784879 504 A180M Transcriptional coactivator YAP1 Homo sapiens -0.232598408848853 0.0487199672528769 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3838105 3784880 504 A180N Transcriptional coactivator YAP1 Homo sapiens 0.110454828819644 0.0886501479506591 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093821 3784880 504 A180N Transcriptional coactivator YAP1 Homo sapiens -0.159789980531497 0.0879777496694514 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094755 3784880 504 A180N Transcriptional coactivator YAP1 Homo sapiens -0.192877479455222 0.0452877985835767 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3838106 3784881 504 A180P Transcriptional coactivator YAP1 Homo sapiens 1.10531657354471 0.0921287392065305 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093822 3784881 504 A180P Transcriptional coactivator YAP1 Homo sapiens -1.08868755831584 0.144026801204889 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094756 3784881 504 A180P Transcriptional coactivator YAP1 Homo sapiens -1.00283688272491 0.158734035879347 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3838107 3784882 504 A180Q Transcriptional coactivator YAP1 Homo sapiens 0.0036374883072934 0.120324085681865 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093823 3784882 504 A180Q Transcriptional coactivator YAP1 Homo sapiens -0.177478268700435 0.0493540152457655 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094757 3784882 504 A180Q Transcriptional coactivator YAP1 Homo sapiens -0.178188545675605 0.079676586900155 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3838109 3784883 504 A180S Transcriptional coactivator YAP1 Homo sapiens 0.031778179227393 0.0888282067307144 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093825 3784883 504 A180S Transcriptional coactivator YAP1 Homo sapiens -0.110105985994902 0.0485204371704187 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094759 3784883 504 A180S Transcriptional coactivator YAP1 Homo sapiens -0.0450235735381402 0.0387119812170734 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3838110 3784884 504 A180T Transcriptional coactivator YAP1 Homo sapiens 0.119933185697565 0.0683429320258461 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093826 3784884 504 A180T Transcriptional coactivator YAP1 Homo sapiens -0.202161085153962 0.0597333585740683 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094760 3784884 504 A180T Transcriptional coactivator YAP1 Homo sapiens -0.182670491889168 0.0503245876263097 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3838111 3784885 504 A180V Transcriptional coactivator YAP1 Homo sapiens 0.0652081331313749 0.0904625811929639 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093827 3784885 504 A180V Transcriptional coactivator YAP1 Homo sapiens -0.15557150764073 0.0434156426022163 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094761 3784885 504 A180V Transcriptional coactivator YAP1 Homo sapiens -0.243855010953536 0.0499800504137446 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3838112 3784886 504 A180W Transcriptional coactivator YAP1 Homo sapiens 0.373604421058342 0.0638820934379604 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093828 3784886 504 A180W Transcriptional coactivator YAP1 Homo sapiens -0.536168121975755 0.0679857126262556 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094762 3784886 504 A180W Transcriptional coactivator YAP1 Homo sapiens -0.57952677231995 0.0561506924718523 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3838113 3784887 504 A180Y Transcriptional coactivator YAP1 Homo sapiens 0.14299287517093 0.0861036941551891 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093829 3784887 504 A180Y Transcriptional coactivator YAP1 Homo sapiens -0.46298120704774 0.0556095384393095 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094763 3784887 504 A180Y Transcriptional coactivator YAP1 Homo sapiens -0.26269066631689 0.0850580407250795 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093190 4905668 503 180A Transcriptional coactivator YAP1 Homo sapiens -1.18186069420443 0.138837506643351 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094144 4905668 503 180A Transcriptional coactivator YAP1 Homo sapiens -1.09282534777296 0.111240005650626 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3839406 3786179 504 K181A Transcriptional coactivator YAP1 Homo sapiens -0.0549978475969746 0.0755966676182565 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093192 3786179 504 K181A Transcriptional coactivator YAP1 Homo sapiens -0.126079182469381 0.0529999811013575 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094146 3786179 504 K181A Transcriptional coactivator YAP1 Homo sapiens -0.0384197192025971 0.0504205483342977 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3839407 3786180 504 K181C Transcriptional coactivator YAP1 Homo sapiens -0.0619864141854118 0.0565382476234799 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093193 3786180 504 K181C Transcriptional coactivator YAP1 Homo sapiens -0.102061371970958 0.0486137773192532 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094147 3786180 504 K181C Transcriptional coactivator YAP1 Homo sapiens -0.144768847114482 0.0629052632339889 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3839408 3786181 504 K181D Transcriptional coactivator YAP1 Homo sapiens 0.181481714931367 0.0582046622010295 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093194 3786181 504 K181D Transcriptional coactivator YAP1 Homo sapiens -0.171043592757547 0.0573096112969848 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094148 3786181 504 K181D Transcriptional coactivator YAP1 Homo sapiens -0.0152870935842098 0.0711890961562616 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3839409 3786182 504 K181E Transcriptional coactivator YAP1 Homo sapiens -0.0689731195596916 0.100910749926687 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093195 3786182 504 K181E Transcriptional coactivator YAP1 Homo sapiens -0.0511198852575374 0.0672743593095489 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094149 3786182 504 K181E Transcriptional coactivator YAP1 Homo sapiens 0.0163239511601811 0.0581780431517373 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3839410 3786183 504 K181F Transcriptional coactivator YAP1 Homo sapiens 0.0241019491465114 0.0761886777562607 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093196 3786183 504 K181F Transcriptional coactivator YAP1 Homo sapiens -0.0223433298546584 0.0649442277562869 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094150 3786183 504 K181F Transcriptional coactivator YAP1 Homo sapiens 0.0730208542498059 0.072669683416659 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3839411 3786184 504 K181G Transcriptional coactivator YAP1 Homo sapiens 0.328569497557721 0.0584375108948264 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093197 3786184 504 K181G Transcriptional coactivator YAP1 Homo sapiens -0.407577581139393 0.0376548272738769 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094151 3786184 504 K181G Transcriptional coactivator YAP1 Homo sapiens -0.571915259678517 0.0477464621709016 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3839412 3786185 504 K181H Transcriptional coactivator YAP1 Homo sapiens -0.00562984041853039 0.114466504893473 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093198 3786185 504 K181H Transcriptional coactivator YAP1 Homo sapiens -0.0574037201549934 0.0615403255187471 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094152 3786185 504 K181H Transcriptional coactivator YAP1 Homo sapiens -0.144970832356555 0.0830394640006221 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3839413 3786186 504 K181I Transcriptional coactivator YAP1 Homo sapiens -0.0312058164891408 0.0818762511474852 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093199 3786186 504 K181I Transcriptional coactivator YAP1 Homo sapiens -0.0984498892485885 0.0718914006549779 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094153 3786186 504 K181I Transcriptional coactivator YAP1 Homo sapiens -0.0413431898115383 0.0745419803026472 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3839414 3786187 504 K181L Transcriptional coactivator YAP1 Homo sapiens -0.0853797943759856 0.118776436597559 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093800 3786187 504 K181L Transcriptional coactivator YAP1 Homo sapiens -0.0398213107967916 0.0529728514690997 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094734 3786187 504 K181L Transcriptional coactivator YAP1 Homo sapiens -0.0835396786808139 0.0540186638261636 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3839415 3786188 504 K181M Transcriptional coactivator YAP1 Homo sapiens 0.0819178640250815 0.0640422242470622 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093801 3786188 504 K181M Transcriptional coactivator YAP1 Homo sapiens -0.0831351719532077 0.0638987977838144 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094735 3786188 504 K181M Transcriptional coactivator YAP1 Homo sapiens -0.196783944908915 0.0761081809568774 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3839416 3786189 504 K181N Transcriptional coactivator YAP1 Homo sapiens -0.0356745804284842 0.0548974680639 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093802 3786189 504 K181N Transcriptional coactivator YAP1 Homo sapiens -0.157402630908598 0.0821634800456369 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094736 3786189 504 K181N Transcriptional coactivator YAP1 Homo sapiens -0.0929429775994645 0.0726954099580177 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3839417 3786190 504 K181P Transcriptional coactivator YAP1 Homo sapiens 0.383696106515751 0.0469899748096254 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093803 3786190 504 K181P Transcriptional coactivator YAP1 Homo sapiens -0.604054569590959 0.07150335481363 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094737 3786190 504 K181P Transcriptional coactivator YAP1 Homo sapiens -0.476445623880765 0.0365301862426186 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3839418 3786191 504 K181Q Transcriptional coactivator YAP1 Homo sapiens -0.100755241770402 0.0984576269064428 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093804 3786191 504 K181Q Transcriptional coactivator YAP1 Homo sapiens -0.0878206719269484 0.0419376396721 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094738 3786191 504 K181Q Transcriptional coactivator YAP1 Homo sapiens -0.162544965857141 0.0747193729555971 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3839419 3786192 504 K181R Transcriptional coactivator YAP1 Homo sapiens -0.115999643484091 0.0917732292979585 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093805 3786192 504 K181R Transcriptional coactivator YAP1 Homo sapiens -0.0451892214616467 0.0342790626928889 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094739 3786192 504 K181R Transcriptional coactivator YAP1 Homo sapiens -0.0941619762533747 0.0434997472615364 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3839420 3786193 504 K181S Transcriptional coactivator YAP1 Homo sapiens -0.070532871037144 0.105901105067661 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093806 3786193 504 K181S Transcriptional coactivator YAP1 Homo sapiens -0.0953366170945459 0.0375371857623864 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094740 3786193 504 K181S Transcriptional coactivator YAP1 Homo sapiens -0.180196349853818 0.0489510950674194 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3839421 3786194 504 K181T Transcriptional coactivator YAP1 Homo sapiens -0.0937720877817824 0.0599557282643264 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093807 3786194 504 K181T Transcriptional coactivator YAP1 Homo sapiens -0.0682127864154179 0.0483213850062347 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094741 3786194 504 K181T Transcriptional coactivator YAP1 Homo sapiens -0.0755970519864124 0.0520045378642332 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3839422 3786195 504 K181V Transcriptional coactivator YAP1 Homo sapiens -0.121235613627578 0.0694276091522377 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093808 3786195 504 K181V Transcriptional coactivator YAP1 Homo sapiens -0.0303661879585885 0.0522898606201183 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094742 3786195 504 K181V Transcriptional coactivator YAP1 Homo sapiens -0.0753114377669207 0.0409235707865343 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3839423 3786196 504 K181W Transcriptional coactivator YAP1 Homo sapiens -0.0785794602297548 0.073427745473234 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093809 3786196 504 K181W Transcriptional coactivator YAP1 Homo sapiens -0.0986094326620265 0.0503646575021352 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094743 3786196 504 K181W Transcriptional coactivator YAP1 Homo sapiens -0.154752587834036 0.0603198166994559 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3839424 3786197 504 K181Y Transcriptional coactivator YAP1 Homo sapiens -0.01542388960014 0.137640331580861 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093810 3786197 504 K181Y Transcriptional coactivator YAP1 Homo sapiens 0.0141333708386056 0.0791667471031376 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094744 3786197 504 K181Y Transcriptional coactivator YAP1 Homo sapiens 0.0404395716233201 0.0643660275918574 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093191 4905669 503 181K Transcriptional coactivator YAP1 Homo sapiens -1.03219751428171 0.165232659041468 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094145 4905669 503 181K Transcriptional coactivator YAP1 Homo sapiens -1.24496129121157 0.15365286678097 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3840717 3787488 504 T182A Transcriptional coactivator YAP1 Homo sapiens 0.160977076397465 0.0616533041130062 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093201 3787488 504 T182A Transcriptional coactivator YAP1 Homo sapiens -0.238207018630943 0.0530482357319491 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094155 3787488 504 T182A Transcriptional coactivator YAP1 Homo sapiens -0.572360619419283 0.0662566732424675 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3840718 3787489 504 T182C Transcriptional coactivator YAP1 Homo sapiens 0.212613312411456 0.0772782239719266 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093202 3787489 504 T182C Transcriptional coactivator YAP1 Homo sapiens -0.323812937900439 0.0542082903950035 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094156 3787489 504 T182C Transcriptional coactivator YAP1 Homo sapiens 0.0054514753755096 0.0759663660553383 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3840719 3787490 504 T182D Transcriptional coactivator YAP1 Homo sapiens -0.146346706563656 0.128946447213028 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093203 3787490 504 T182D Transcriptional coactivator YAP1 Homo sapiens -0.0926439593941128 0.0730210622977724 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094157 3787490 504 T182D Transcriptional coactivator YAP1 Homo sapiens 0.0173282076093617 0.0731224847189748 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3840720 3787491 504 T182E Transcriptional coactivator YAP1 Homo sapiens 0.334352978616808 0.0665006169564842 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093204 3787491 504 T182E Transcriptional coactivator YAP1 Homo sapiens -0.365088269351517 0.071186755413609 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094158 3787491 504 T182E Transcriptional coactivator YAP1 Homo sapiens -0.241112263982238 0.046430290897551 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3840721 3787492 504 T182F Transcriptional coactivator YAP1 Homo sapiens 0.517847786831933 0.0647672211748773 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093205 3787492 504 T182F Transcriptional coactivator YAP1 Homo sapiens -0.575441908785521 0.0996160790810868 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094159 3787492 504 T182F Transcriptional coactivator YAP1 Homo sapiens -0.550836646791969 0.0714166661956631 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3840722 3787493 504 T182G Transcriptional coactivator YAP1 Homo sapiens 0.257675985332345 0.0854754724865995 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093206 3787493 504 T182G Transcriptional coactivator YAP1 Homo sapiens -0.342962498697002 0.0395031957343429 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094160 3787493 504 T182G Transcriptional coactivator YAP1 Homo sapiens -0.525389482915477 0.0468837583968056 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3840723 3787494 504 T182H Transcriptional coactivator YAP1 Homo sapiens 0.244987242209658 0.117303973138363 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093207 3787494 504 T182H Transcriptional coactivator YAP1 Homo sapiens -0.238264309220314 0.0546808217257402 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094161 3787494 504 T182H Transcriptional coactivator YAP1 Homo sapiens -0.270418550806562 0.0464676971469425 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3840724 3787495 504 T182I Transcriptional coactivator YAP1 Homo sapiens 0.579655862042413 0.108131799492718 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093208 3787495 504 T182I Transcriptional coactivator YAP1 Homo sapiens -0.453586275588243 0.0887679246843698 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094162 3787495 504 T182I Transcriptional coactivator YAP1 Homo sapiens -0.802160788509279 0.0804153567820363 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3840725 3787496 504 T182K Transcriptional coactivator YAP1 Homo sapiens 0.407207551149738 0.12745035286066 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093209 3787496 504 T182K Transcriptional coactivator YAP1 Homo sapiens -0.499078629535422 0.0442480241019624 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094163 3787496 504 T182K Transcriptional coactivator YAP1 Homo sapiens -0.522692306649671 0.106148205750034 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3840726 3787497 504 T182L Transcriptional coactivator YAP1 Homo sapiens 0.333924055400113 0.119989562256991 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093210 3787497 504 T182L Transcriptional coactivator YAP1 Homo sapiens -0.314940148521284 0.0550148693736127 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094164 3787497 504 T182L Transcriptional coactivator YAP1 Homo sapiens -0.206468605726172 0.0532384409028478 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3840727 3787498 504 T182M Transcriptional coactivator YAP1 Homo sapiens 0.286326980439272 0.0700455660109455 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093211 3787498 504 T182M Transcriptional coactivator YAP1 Homo sapiens -0.372340242689608 0.0492704290010707 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094165 3787498 504 T182M Transcriptional coactivator YAP1 Homo sapiens -0.396387887285219 0.0423976023855662 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3840728 3787499 504 T182N Transcriptional coactivator YAP1 Homo sapiens 0.0324058315039852 0.0920319650725856 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093212 3787499 504 T182N Transcriptional coactivator YAP1 Homo sapiens -0.334212267667261 0.104595574053954 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094166 3787499 504 T182N Transcriptional coactivator YAP1 Homo sapiens -0.513891915960603 0.227627233117387 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3840729 3787500 504 T182P Transcriptional coactivator YAP1 Homo sapiens 0.810717092574094 0.146486196350212 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093213 3787500 504 T182P Transcriptional coactivator YAP1 Homo sapiens -0.579920727519126 0.0816143606244767 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094167 3787500 504 T182P Transcriptional coactivator YAP1 Homo sapiens -0.678109319622103 0.0993391060597398 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3840730 3787501 504 T182Q Transcriptional coactivator YAP1 Homo sapiens 0.386762631258724 0.171326901230768 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093214 3787501 504 T182Q Transcriptional coactivator YAP1 Homo sapiens -0.463505524720084 0.0824951127863879 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094168 3787501 504 T182Q Transcriptional coactivator YAP1 Homo sapiens -0.535644592579555 0.0512027627612283 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3840731 3787502 504 T182R Transcriptional coactivator YAP1 Homo sapiens 0.674283905786132 0.0659098209962768 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093215 3787502 504 T182R Transcriptional coactivator YAP1 Homo sapiens -0.654753115197553 0.0429320375081924 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094169 3787502 504 T182R Transcriptional coactivator YAP1 Homo sapiens -0.669193265804942 0.0600839262855213 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3840732 3787503 504 T182S Transcriptional coactivator YAP1 Homo sapiens -0.0332787229393612 0.0953965879065276 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093216 3787503 504 T182S Transcriptional coactivator YAP1 Homo sapiens -0.138661356210969 0.0570002203584618 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094170 3787503 504 T182S Transcriptional coactivator YAP1 Homo sapiens -0.261997538012515 0.0636099153279637 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3840733 3787504 504 T182V Transcriptional coactivator YAP1 Homo sapiens 0.537370820569059 0.0924552281277252 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093797 3787504 504 T182V Transcriptional coactivator YAP1 Homo sapiens -0.436644215475795 0.0407521813464423 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094731 3787504 504 T182V Transcriptional coactivator YAP1 Homo sapiens -0.406903168115489 0.0410769945240915 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3840734 3787505 504 T182W Transcriptional coactivator YAP1 Homo sapiens 0.682760644751321 0.146408416953256 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093798 3787505 504 T182W Transcriptional coactivator YAP1 Homo sapiens -0.665325984686356 0.0396626593760741 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094732 3787505 504 T182W Transcriptional coactivator YAP1 Homo sapiens -0.633860731565387 0.0520348569121485 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3840735 3787506 504 T182Y Transcriptional coactivator YAP1 Homo sapiens 0.731952321130641 0.0586749338543731 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093799 3787506 504 T182Y Transcriptional coactivator YAP1 Homo sapiens -0.605466528799885 0.0575020351575377 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094733 3787506 504 T182Y Transcriptional coactivator YAP1 Homo sapiens -0.828938574462932 0.212622210151931 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093200 4905670 503 182T Transcriptional coactivator YAP1 Homo sapiens -1.36654599576418 0.114774153752365 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094154 4905670 503 182T Transcriptional coactivator YAP1 Homo sapiens -1.19330895253341 0.0877598945438595 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3842028 3788796 504 S183A Transcriptional coactivator YAP1 Homo sapiens -0.123401761955854 0.114301122399684 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093218 3788796 504 S183A Transcriptional coactivator YAP1 Homo sapiens -0.0479514981061255 0.0508593798712865 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094172 3788796 504 S183A Transcriptional coactivator YAP1 Homo sapiens -0.0258448976233371 0.0592646387076687 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3842029 3788797 504 S183C Transcriptional coactivator YAP1 Homo sapiens 0.0525002771172337 0.0996746977997548 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093219 3788797 504 S183C Transcriptional coactivator YAP1 Homo sapiens -0.135631481750315 0.0758668091553727 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094173 3788797 504 S183C Transcriptional coactivator YAP1 Homo sapiens -0.369740009734626 0.104511558313131 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3842030 3788798 504 S183D Transcriptional coactivator YAP1 Homo sapiens -0.197849698098573 0.124798274599112 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093220 3788798 504 S183D Transcriptional coactivator YAP1 Homo sapiens -0.0733914205761487 0.0636066302819693 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094174 3788798 504 S183D Transcriptional coactivator YAP1 Homo sapiens -0.456702098008307 0.111700177642477 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3842031 3788799 504 S183E Transcriptional coactivator YAP1 Homo sapiens -0.173284326881896 0.0811246987221473 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093221 3788799 504 S183E Transcriptional coactivator YAP1 Homo sapiens -0.0324808633839759 0.0622439482318754 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094175 3788799 504 S183E Transcriptional coactivator YAP1 Homo sapiens -0.06248643797555 0.0641641982682175 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3842032 3788800 504 S183F Transcriptional coactivator YAP1 Homo sapiens 0.244098124227637 0.106412560866682 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093222 3788800 504 S183F Transcriptional coactivator YAP1 Homo sapiens -0.383295798811463 0.0808291169514282 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094176 3788800 504 S183F Transcriptional coactivator YAP1 Homo sapiens -0.158839068205225 0.0783653837550393 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3842033 3788801 504 S183G Transcriptional coactivator YAP1 Homo sapiens -0.0931748113304425 0.0964102857067933 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093223 3788801 504 S183G Transcriptional coactivator YAP1 Homo sapiens -0.109936289818791 0.0320823964569411 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094177 3788801 504 S183G Transcriptional coactivator YAP1 Homo sapiens -0.0963065634200792 0.0425472061215278 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3842034 3788802 504 S183H Transcriptional coactivator YAP1 Homo sapiens -0.0794724379243274 0.0951571169362393 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093224 3788802 504 S183H Transcriptional coactivator YAP1 Homo sapiens -0.808138080357115 0.0447095686930919 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094178 3788802 504 S183H Transcriptional coactivator YAP1 Homo sapiens -0.299889260705134 0.183904728026251 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3842035 3788803 504 S183I Transcriptional coactivator YAP1 Homo sapiens -0.0381683148265668 0.0731131170098507 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093225 3788803 504 S183I Transcriptional coactivator YAP1 Homo sapiens -0.161320872103169 0.0390675769478971 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094179 3788803 504 S183I Transcriptional coactivator YAP1 Homo sapiens -0.0403743693697389 0.100695950782362 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3842036 3788804 504 S183K Transcriptional coactivator YAP1 Homo sapiens -0.223114735050865 0.106017398319367 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093226 3788804 504 S183K Transcriptional coactivator YAP1 Homo sapiens -0.0340864502810293 0.0560100359188789 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094180 3788804 504 S183K Transcriptional coactivator YAP1 Homo sapiens 0.120951597833492 0.0673008518975636 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3842037 3788805 504 S183L Transcriptional coactivator YAP1 Homo sapiens 0.0652752876286488 0.0817770081478442 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093227 3788805 504 S183L Transcriptional coactivator YAP1 Homo sapiens -0.1704634348905 0.0616671262725636 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094181 3788805 504 S183L Transcriptional coactivator YAP1 Homo sapiens -0.136741882722514 0.0393700136997376 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3842038 3788806 504 S183M Transcriptional coactivator YAP1 Homo sapiens -0.059012079183108 0.0470585910464342 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093228 3788806 504 S183M Transcriptional coactivator YAP1 Homo sapiens -0.15021592533055 0.0403201087749588 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094182 3788806 504 S183M Transcriptional coactivator YAP1 Homo sapiens -0.0821881493592983 0.0651642803557286 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3842039 3788807 504 S183N Transcriptional coactivator YAP1 Homo sapiens -0.161294731865735 0.103657025429544 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093229 3788807 504 S183N Transcriptional coactivator YAP1 Homo sapiens 0.0624634219529793 0.0632110786482165 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094183 3788807 504 S183N Transcriptional coactivator YAP1 Homo sapiens -0.114571699064597 0.195968278891017 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3842040 3788808 504 S183P Transcriptional coactivator YAP1 Homo sapiens -0.137037338703935 0.113482109400741 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093230 3788808 504 S183P Transcriptional coactivator YAP1 Homo sapiens -0.104078870953615 0.0464993049491194 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094184 3788808 504 S183P Transcriptional coactivator YAP1 Homo sapiens -0.117381065729772 0.0708519650692392 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3842041 3788809 504 S183Q Transcriptional coactivator YAP1 Homo sapiens -0.0450268136031403 0.0965857957262278 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093231 3788809 504 S183Q Transcriptional coactivator YAP1 Homo sapiens -0.0753523541667685 0.041951324145789 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094185 3788809 504 S183Q Transcriptional coactivator YAP1 Homo sapiens -0.295738995520658 0.0800590831638267 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3842042 3788810 504 S183R Transcriptional coactivator YAP1 Homo sapiens -0.0670837362522525 0.0693585281745299 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093232 3788810 504 S183R Transcriptional coactivator YAP1 Homo sapiens -0.0872666211639182 0.0468149688445798 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094186 3788810 504 S183R Transcriptional coactivator YAP1 Homo sapiens -0.0500243028997621 0.0462716226309014 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3842043 3788811 504 S183T Transcriptional coactivator YAP1 Homo sapiens -0.147102591319409 0.0866976060174535 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093793 3788811 504 S183T Transcriptional coactivator YAP1 Homo sapiens 0.0220445485531289 0.0688049753062331 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094727 3788811 504 S183T Transcriptional coactivator YAP1 Homo sapiens -0.124373298706212 0.077528527004727 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3842044 3788812 504 S183V Transcriptional coactivator YAP1 Homo sapiens 0.017493352691641 0.0714744878615495 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093794 3788812 504 S183V Transcriptional coactivator YAP1 Homo sapiens -0.0928992288556137 0.0559887223692383 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094728 3788812 504 S183V Transcriptional coactivator YAP1 Homo sapiens -0.0835049513935804 0.0549174272813706 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3842045 3788813 504 S183W Transcriptional coactivator YAP1 Homo sapiens 0.293354538001444 0.0563915594167515 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093795 3788813 504 S183W Transcriptional coactivator YAP1 Homo sapiens -0.391088044163241 0.0644472137635608 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094729 3788813 504 S183W Transcriptional coactivator YAP1 Homo sapiens -0.421873463793711 0.0643884231485222 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3842046 3788814 504 S183Y Transcriptional coactivator YAP1 Homo sapiens 0.101127619635577 0.0454425260252709 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093796 3788814 504 S183Y Transcriptional coactivator YAP1 Homo sapiens -0.630790202137299 0.126854708498157 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094730 3788814 504 S183Y Transcriptional coactivator YAP1 Homo sapiens -0.685731888297838 0.22277540585878 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093217 4905671 503 183S Transcriptional coactivator YAP1 Homo sapiens -1.31960060743109 0.125518967529014 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093233 4905671 503 183S Transcriptional coactivator YAP1 Homo sapiens -1.14500232215438 0.210138545904795 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094171 4905671 503 183S Transcriptional coactivator YAP1 Homo sapiens -1.02723081759002 0.123625386334426 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094187 4905671 503 183S Transcriptional coactivator YAP1 Homo sapiens -0.982940840276679 0.161022847596093 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3843320 3790086 504 S184A Transcriptional coactivator YAP1 Homo sapiens -0.0883061946741292 0.0837643482591674 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093234 3790086 504 S184A Transcriptional coactivator YAP1 Homo sapiens -0.208503661035456 0.0605902154838304 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094188 3790086 504 S184A Transcriptional coactivator YAP1 Homo sapiens -0.0725949134410849 0.0649763348597807 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3843321 3790087 504 S184C Transcriptional coactivator YAP1 Homo sapiens -0.0155767961076147 0.084497029728386 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093235 3790087 504 S184C Transcriptional coactivator YAP1 Homo sapiens -0.103841731425459 0.0594145618261258 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094189 3790087 504 S184C Transcriptional coactivator YAP1 Homo sapiens -0.0245465223128934 0.0537493076468583 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3843322 3790088 504 S184D Transcriptional coactivator YAP1 Homo sapiens -0.190208828836123 0.0485358887112043 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093236 3790088 504 S184D Transcriptional coactivator YAP1 Homo sapiens 0.14891564651103 0.0832308254815372 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094190 3790088 504 S184D Transcriptional coactivator YAP1 Homo sapiens 0.200920035690438 0.0457169357201634 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3843323 3790089 504 S184E Transcriptional coactivator YAP1 Homo sapiens -0.160239207384554 0.115830277496881 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093237 3790089 504 S184E Transcriptional coactivator YAP1 Homo sapiens 0.0934119433706165 0.0489739610790362 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094191 3790089 504 S184E Transcriptional coactivator YAP1 Homo sapiens 0.0337230307843049 0.0638055575247148 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3843324 3790090 504 S184F Transcriptional coactivator YAP1 Homo sapiens 0.167834649068082 0.0801609071177009 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093238 3790090 504 S184F Transcriptional coactivator YAP1 Homo sapiens -0.21267572129686 0.0493496858176827 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094192 3790090 504 S184F Transcriptional coactivator YAP1 Homo sapiens -0.292009710103871 0.0523431856123715 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3843325 3790091 504 S184G Transcriptional coactivator YAP1 Homo sapiens -0.117660940285347 0.0950031785464294 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093239 3790091 504 S184G Transcriptional coactivator YAP1 Homo sapiens -0.0815375622268265 0.0420284706381596 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094193 3790091 504 S184G Transcriptional coactivator YAP1 Homo sapiens -0.0711767644256929 0.0465910215398302 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3843326 3790092 504 S184H Transcriptional coactivator YAP1 Homo sapiens 0.0182910978867282 0.069904916060063 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093240 3790092 504 S184H Transcriptional coactivator YAP1 Homo sapiens -0.135152851510001 0.0771094347868546 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094194 3790092 504 S184H Transcriptional coactivator YAP1 Homo sapiens 0.111667363899642 0.0597416073670184 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3843327 3790093 504 S184I Transcriptional coactivator YAP1 Homo sapiens 0.136478389310759 0.0984567773195693 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093241 3790093 504 S184I Transcriptional coactivator YAP1 Homo sapiens -0.322759951371748 0.098616394556431 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094195 3790093 504 S184I Transcriptional coactivator YAP1 Homo sapiens -0.168152359665128 0.073458630684992 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3843328 3790094 504 S184K Transcriptional coactivator YAP1 Homo sapiens -0.144500053537476 0.0792329782068454 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093242 3790094 504 S184K Transcriptional coactivator YAP1 Homo sapiens -0.05310039917617 0.0483295869880801 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094196 3790094 504 S184K Transcriptional coactivator YAP1 Homo sapiens 0.0554927875588147 0.0832835472194632 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3843329 3790095 504 S184L Transcriptional coactivator YAP1 Homo sapiens 0.0907682130377322 0.096985517910645 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093243 3790095 504 S184L Transcriptional coactivator YAP1 Homo sapiens -0.129097453772695 0.0572566211278034 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094197 3790095 504 S184L Transcriptional coactivator YAP1 Homo sapiens -0.192226165639557 0.0377291493779554 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3843330 3790096 504 S184M Transcriptional coactivator YAP1 Homo sapiens 0.0667438598674351 0.0871503514250274 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093244 3790096 504 S184M Transcriptional coactivator YAP1 Homo sapiens -0.32027397491145 0.0710620504800872 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094198 3790096 504 S184M Transcriptional coactivator YAP1 Homo sapiens -0.134653284447471 0.0595954976213846 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3843331 3790097 504 S184N Transcriptional coactivator YAP1 Homo sapiens -0.0701642369806162 0.114356092358326 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093245 3790097 504 S184N Transcriptional coactivator YAP1 Homo sapiens 0.0215108033154456 0.0734917878871479 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094199 3790097 504 S184N Transcriptional coactivator YAP1 Homo sapiens 0.00320199762695691 0.0595273116559819 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3843332 3790098 504 S184P Transcriptional coactivator YAP1 Homo sapiens 0.413446219475359 0.04440973108748 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093246 3790098 504 S184P Transcriptional coactivator YAP1 Homo sapiens -0.636674163224892 0.0946155533855395 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094200 3790098 504 S184P Transcriptional coactivator YAP1 Homo sapiens -0.511191196094059 0.0902881827984868 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3843333 3790099 504 S184Q Transcriptional coactivator YAP1 Homo sapiens -0.0627398503305198 0.0730816204050935 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093247 3790099 504 S184Q Transcriptional coactivator YAP1 Homo sapiens 0.0148020027803775 0.056321210842843 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094201 3790099 504 S184Q Transcriptional coactivator YAP1 Homo sapiens -0.011788850935547 0.0824153650386261 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3843334 3790100 504 S184R Transcriptional coactivator YAP1 Homo sapiens -0.0132594224411209 0.0978500597637666 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093248 3790100 504 S184R Transcriptional coactivator YAP1 Homo sapiens -0.169562014604575 0.037235742986642 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094202 3790100 504 S184R Transcriptional coactivator YAP1 Homo sapiens -0.0875609567984219 0.0315520508793029 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3843335 3790101 504 S184T Transcriptional coactivator YAP1 Homo sapiens -0.0691952049442886 0.0799230047886069 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093789 3790101 504 S184T Transcriptional coactivator YAP1 Homo sapiens -0.11727166085027 0.058470347645533 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094723 3790101 504 S184T Transcriptional coactivator YAP1 Homo sapiens 0.0546316925794538 0.0487027382660882 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3843336 3790102 504 S184V Transcriptional coactivator YAP1 Homo sapiens 0.084043991747849 0.0744221334579358 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093790 3790102 504 S184V Transcriptional coactivator YAP1 Homo sapiens -0.18277003364524 0.0349919244200499 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094724 3790102 504 S184V Transcriptional coactivator YAP1 Homo sapiens -0.179756943362293 0.0473512514677816 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3843337 3790103 504 S184W Transcriptional coactivator YAP1 Homo sapiens 0.227674878528826 0.0829090112015767 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093791 3790103 504 S184W Transcriptional coactivator YAP1 Homo sapiens -0.524915960144373 0.0621029843741295 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094725 3790103 504 S184W Transcriptional coactivator YAP1 Homo sapiens -0.289795668362699 0.0383314764570166 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3843338 3790104 504 S184Y Transcriptional coactivator YAP1 Homo sapiens 0.139337119733102 0.103349126144312 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093792 3790104 504 S184Y Transcriptional coactivator YAP1 Homo sapiens -0.237668922209257 0.0790987961129597 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094726 3790104 504 S184Y Transcriptional coactivator YAP1 Homo sapiens -0.0212495561861551 0.0604986055310965 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3844821 3791584 504 G185A Transcriptional coactivator YAP1 Homo sapiens 0.244967223467299 0.0702026911954918 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093250 3791584 504 G185A Transcriptional coactivator YAP1 Homo sapiens -0.488406625571087 0.0459442824216619 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094204 3791584 504 G185A Transcriptional coactivator YAP1 Homo sapiens -0.406626058537768 0.0347300654164642 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3844822 3791585 504 G185C Transcriptional coactivator YAP1 Homo sapiens 0.309450732138746 0.0654588006439045 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093251 3791585 504 G185C Transcriptional coactivator YAP1 Homo sapiens -0.579220186894666 0.0484716313898533 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094205 3791585 504 G185C Transcriptional coactivator YAP1 Homo sapiens -0.50427458355737 0.0508863759129268 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3844823 3791586 504 G185D Transcriptional coactivator YAP1 Homo sapiens 0.11894659590761 0.089766870818754 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093252 3791586 504 G185D Transcriptional coactivator YAP1 Homo sapiens -0.252215655528134 0.0668062226746551 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094206 3791586 504 G185D Transcriptional coactivator YAP1 Homo sapiens -0.221495599016204 0.0555573874002705 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3844824 3791587 504 G185E Transcriptional coactivator YAP1 Homo sapiens 0.156358440832498 0.0864873585850552 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093253 3791587 504 G185E Transcriptional coactivator YAP1 Homo sapiens -0.309633154432469 0.0585452387741955 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094207 3791587 504 G185E Transcriptional coactivator YAP1 Homo sapiens -0.290232948693782 0.0491752065525005 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3844825 3791588 504 G185F Transcriptional coactivator YAP1 Homo sapiens 0.480028128954918 0.19109406459998 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093254 3791588 504 G185F Transcriptional coactivator YAP1 Homo sapiens -0.842779379118242 0.110260090428336 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094208 3791588 504 G185F Transcriptional coactivator YAP1 Homo sapiens -0.785541513663584 0.142646301144369 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3844826 3791589 504 G185H Transcriptional coactivator YAP1 Homo sapiens 0.165451079643409 0.0863656099728689 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093775 3791589 504 G185H Transcriptional coactivator YAP1 Homo sapiens -0.283019862676343 0.0871761165366589 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094709 3791589 504 G185H Transcriptional coactivator YAP1 Homo sapiens -0.611417478034592 0.16714427612715 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3844827 3791590 504 G185I Transcriptional coactivator YAP1 Homo sapiens 0.993287685304434 0.146329287219546 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093776 3791590 504 G185I Transcriptional coactivator YAP1 Homo sapiens -1.15172207316919 0.144564897626576 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094710 3791590 504 G185I Transcriptional coactivator YAP1 Homo sapiens -0.617561372994329 0.13955798222909 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3844828 3791591 504 G185K Transcriptional coactivator YAP1 Homo sapiens 0.19898653535788 0.201245750020435 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093777 3791591 504 G185K Transcriptional coactivator YAP1 Homo sapiens -0.523741865660936 0.0688451657424728 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094711 3791591 504 G185K Transcriptional coactivator YAP1 Homo sapiens -0.398920144372673 0.0412283204500118 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3844829 3791592 504 G185L Transcriptional coactivator YAP1 Homo sapiens 0.48352860691899 0.120796478489191 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093778 3791592 504 G185L Transcriptional coactivator YAP1 Homo sapiens -0.595971520108322 0.069321569626972 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094712 3791592 504 G185L Transcriptional coactivator YAP1 Homo sapiens -0.674108948748849 0.0713389904674837 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3844830 3791593 504 G185M Transcriptional coactivator YAP1 Homo sapiens 0.222134255534716 0.157058016545663 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093779 3791593 504 G185M Transcriptional coactivator YAP1 Homo sapiens -0.411057803144343 0.0773297497368658 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094713 3791593 504 G185M Transcriptional coactivator YAP1 Homo sapiens -0.243419856782896 0.0610224205922041 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3844831 3791594 504 G185N Transcriptional coactivator YAP1 Homo sapiens 1.38915555851709E-4 0.117780159266684 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093780 3791594 504 G185N Transcriptional coactivator YAP1 Homo sapiens -0.0591478197428041 0.0825471819549554 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094714 3791594 504 G185N Transcriptional coactivator YAP1 Homo sapiens -0.0661873745864329 0.0606213558606647 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3844832 3791595 504 G185P Transcriptional coactivator YAP1 Homo sapiens 0.756779207565094 0.0967338826567759 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093781 3791595 504 G185P Transcriptional coactivator YAP1 Homo sapiens -0.695648660804916 0.0341141238112874 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094715 3791595 504 G185P Transcriptional coactivator YAP1 Homo sapiens -0.801430877629243 0.19191680929512 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3844833 3791596 504 G185Q Transcriptional coactivator YAP1 Homo sapiens 0.12831351061861 0.0989008580663132 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093782 3791596 504 G185Q Transcriptional coactivator YAP1 Homo sapiens -0.38995311033583 0.0503498127127122 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094716 3791596 504 G185Q Transcriptional coactivator YAP1 Homo sapiens -0.268560995299644 0.0479113317388429 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3844834 3791597 504 G185R Transcriptional coactivator YAP1 Homo sapiens 0.31275847203698 0.118085058553764 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093783 3791597 504 G185R Transcriptional coactivator YAP1 Homo sapiens -0.650677288622346 0.0420815188231277 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094717 3791597 504 G185R Transcriptional coactivator YAP1 Homo sapiens -0.581757752472649 0.0510412241779808 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3844835 3791598 504 G185S Transcriptional coactivator YAP1 Homo sapiens 0.269181000751987 0.104896432018026 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093784 3791598 504 G185S Transcriptional coactivator YAP1 Homo sapiens -0.386645485296327 0.0452591812484391 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094718 3791598 504 G185S Transcriptional coactivator YAP1 Homo sapiens -0.36896963093416 0.0634500776730705 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3844836 3791599 504 G185T Transcriptional coactivator YAP1 Homo sapiens 0.453976070731917 0.091582449220412 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093785 3791599 504 G185T Transcriptional coactivator YAP1 Homo sapiens -0.611862261645948 0.0841959180933703 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094719 3791599 504 G185T Transcriptional coactivator YAP1 Homo sapiens -0.729023633283249 0.0997182713387176 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3844837 3791600 504 G185V Transcriptional coactivator YAP1 Homo sapiens 0.866498828660511 0.0765824359533534 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093786 3791600 504 G185V Transcriptional coactivator YAP1 Homo sapiens -0.828624977556956 0.0464766280284911 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094720 3791600 504 G185V Transcriptional coactivator YAP1 Homo sapiens -0.651616793527868 0.041840293210282 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3844838 3791601 504 G185W Transcriptional coactivator YAP1 Homo sapiens 0.708512916962412 0.120745176945394 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093787 3791601 504 G185W Transcriptional coactivator YAP1 Homo sapiens -1.12818941968709 0.0631420906258512 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094721 3791601 504 G185W Transcriptional coactivator YAP1 Homo sapiens -1.06698555293469 0.0766718969622961 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3844839 3791602 504 G185Y Transcriptional coactivator YAP1 Homo sapiens 0.377288027191695 0.0545272057263046 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093788 3791602 504 G185Y Transcriptional coactivator YAP1 Homo sapiens -0.580394281378103 0.0602483864685662 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094722 3791602 504 G185Y Transcriptional coactivator YAP1 Homo sapiens -0.621066986332527 0.189942456707874 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093249 4905672 503 185G Transcriptional coactivator YAP1 Homo sapiens -1.39628271243702 0.19151468065551 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094203 4905672 503 185G Transcriptional coactivator YAP1 Homo sapiens -0.996761379259415 0.0625979054803681 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3846094 3792855 504 Q186A Transcriptional coactivator YAP1 Homo sapiens -0.0686585721165133 0.0809787948360161 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093256 3792855 504 Q186A Transcriptional coactivator YAP1 Homo sapiens 0.00417641144540654 0.0382694102583601 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094210 3792855 504 Q186A Transcriptional coactivator YAP1 Homo sapiens -0.0520328157981234 0.0544412736501907 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3846095 3792856 504 Q186C Transcriptional coactivator YAP1 Homo sapiens 0.0828462092897691 0.0863191291312791 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093257 3792856 504 Q186C Transcriptional coactivator YAP1 Homo sapiens -0.202079137855241 0.0788652100517398 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094211 3792856 504 Q186C Transcriptional coactivator YAP1 Homo sapiens -0.20920213933555 0.0785159867864089 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3846096 3792857 504 Q186D Transcriptional coactivator YAP1 Homo sapiens -0.0803155600607091 0.101010657967179 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093258 3792857 504 Q186D Transcriptional coactivator YAP1 Homo sapiens 0.151639487696817 0.0403938178319672 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094212 3792857 504 Q186D Transcriptional coactivator YAP1 Homo sapiens -0.0875212684701551 0.102948830387624 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3846097 3792858 504 Q186E Transcriptional coactivator YAP1 Homo sapiens -0.262665142049451 0.113637623183429 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093259 3792858 504 Q186E Transcriptional coactivator YAP1 Homo sapiens 0.175206950650945 0.066572868676582 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094213 3792858 504 Q186E Transcriptional coactivator YAP1 Homo sapiens 0.263040774069815 0.0657580319210035 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3846098 3792859 504 Q186F Transcriptional coactivator YAP1 Homo sapiens 0.345619389532244 0.0982088059794226 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093260 3792859 504 Q186F Transcriptional coactivator YAP1 Homo sapiens -0.306030374078106 0.072164393939317 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094214 3792859 504 Q186F Transcriptional coactivator YAP1 Homo sapiens -0.597714586596362 0.101584118871362 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3846099 3792860 504 Q186G Transcriptional coactivator YAP1 Homo sapiens 0.102800862415973 0.0736721170406541 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093261 3792860 504 Q186G Transcriptional coactivator YAP1 Homo sapiens -0.271579874735504 0.0519643557968381 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094215 3792860 504 Q186G Transcriptional coactivator YAP1 Homo sapiens -0.175406819096188 0.0347175706802617 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3846100 3792861 504 Q186H Transcriptional coactivator YAP1 Homo sapiens 0.0541983964764565 0.0985013046739901 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093262 3792861 504 Q186H Transcriptional coactivator YAP1 Homo sapiens -0.0465888523158983 0.0782477045220013 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094216 3792861 504 Q186H Transcriptional coactivator YAP1 Homo sapiens -0.109955804743134 0.0804760940986875 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3846101 3792862 504 Q186I Transcriptional coactivator YAP1 Homo sapiens 0.1830227754976 0.113611511046474 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093263 3792862 504 Q186I Transcriptional coactivator YAP1 Homo sapiens -0.272259384637283 0.0779852556068958 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094217 3792862 504 Q186I Transcriptional coactivator YAP1 Homo sapiens -0.246297260582242 0.0714968933163739 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3846102 3792863 504 Q186K Transcriptional coactivator YAP1 Homo sapiens -0.0418597562889273 0.0787270407840207 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093264 3792863 504 Q186K Transcriptional coactivator YAP1 Homo sapiens -0.167457491941861 0.0765632886747629 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094218 3792863 504 Q186K Transcriptional coactivator YAP1 Homo sapiens -0.205903755768517 0.0498801846577432 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3846103 3792864 504 Q186L Transcriptional coactivator YAP1 Homo sapiens 0.14552960654178 0.0589292022649099 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093265 3792864 504 Q186L Transcriptional coactivator YAP1 Homo sapiens -0.102217289397727 0.0546901405114796 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094219 3792864 504 Q186L Transcriptional coactivator YAP1 Homo sapiens -0.248592096420242 0.0445201696172842 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3846104 3792865 504 Q186M Transcriptional coactivator YAP1 Homo sapiens 0.108595747068936 0.0774012756590793 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093266 3792865 504 Q186M Transcriptional coactivator YAP1 Homo sapiens -0.161051823892325 0.0641067046074441 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094220 3792865 504 Q186M Transcriptional coactivator YAP1 Homo sapiens -0.166076518352742 0.05320306868028 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3846105 3792866 504 Q186N Transcriptional coactivator YAP1 Homo sapiens 0.00236858653817738 0.104825573096928 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093267 3792866 504 Q186N Transcriptional coactivator YAP1 Homo sapiens -0.178708203378576 0.0814253741992861 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094221 3792866 504 Q186N Transcriptional coactivator YAP1 Homo sapiens -0.19662731775629 0.0948172589018661 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3846106 3792867 504 Q186P Transcriptional coactivator YAP1 Homo sapiens 0.580766041403661 0.101626006425393 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093268 3792867 504 Q186P Transcriptional coactivator YAP1 Homo sapiens -0.660593346885918 0.0462328021809179 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094222 3792867 504 Q186P Transcriptional coactivator YAP1 Homo sapiens -0.475975033702744 0.0809166345424495 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3846107 3792868 504 Q186R Transcriptional coactivator YAP1 Homo sapiens -0.0549303487638287 0.0804850442023846 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093769 3792868 504 Q186R Transcriptional coactivator YAP1 Homo sapiens -0.260686685584358 0.043580820798938 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094703 3792868 504 Q186R Transcriptional coactivator YAP1 Homo sapiens -0.298515761059042 0.0437764741303769 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3846108 3792869 504 Q186S Transcriptional coactivator YAP1 Homo sapiens -0.0312736270250204 0.06513588223814 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093770 3792869 504 Q186S Transcriptional coactivator YAP1 Homo sapiens -0.0430477137349082 0.0419288430284409 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094704 3792869 504 Q186S Transcriptional coactivator YAP1 Homo sapiens -0.0427592126664874 0.0406119748864307 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3846109 3792870 504 Q186T Transcriptional coactivator YAP1 Homo sapiens -0.0221614724721914 0.0987424815697094 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093771 3792870 504 Q186T Transcriptional coactivator YAP1 Homo sapiens -0.37797212518397 0.0491822667611995 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094705 3792870 504 Q186T Transcriptional coactivator YAP1 Homo sapiens -0.312168545982835 0.0631349381722288 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3846110 3792871 504 Q186V Transcriptional coactivator YAP1 Homo sapiens 0.0668786966185972 0.095090144734427 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093772 3792871 504 Q186V Transcriptional coactivator YAP1 Homo sapiens -0.0983403844511832 0.0433801079328597 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094706 3792871 504 Q186V Transcriptional coactivator YAP1 Homo sapiens -0.118091203317689 0.0517346288832128 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3846111 3792872 504 Q186W Transcriptional coactivator YAP1 Homo sapiens 0.401179479093509 0.0789844037162825 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093773 3792872 504 Q186W Transcriptional coactivator YAP1 Homo sapiens -0.441186126377442 0.0626745414007978 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094707 3792872 504 Q186W Transcriptional coactivator YAP1 Homo sapiens -0.570641193469137 0.0728066081491796 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3846112 3792873 504 Q186Y Transcriptional coactivator YAP1 Homo sapiens 0.325095677491709 0.113239723953628 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093774 3792873 504 Q186Y Transcriptional coactivator YAP1 Homo sapiens -0.383287096443457 0.0777159898368525 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094708 3792873 504 Q186Y Transcriptional coactivator YAP1 Homo sapiens -0.486412355316775 0.136743938010942 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093255 4905673 503 186Q Transcriptional coactivator YAP1 Homo sapiens -1.47208814814204 0.200315095340751 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094209 4905673 503 186Q Transcriptional coactivator YAP1 Homo sapiens -1.14192472835687 0.123044873661509 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3847348 3794108 504 R187A Transcriptional coactivator YAP1 Homo sapiens -0.0326745935290013 0.0706691200154932 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093270 3794108 504 R187A Transcriptional coactivator YAP1 Homo sapiens -0.245674375577176 0.0476078488455533 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094224 3794108 504 R187A Transcriptional coactivator YAP1 Homo sapiens -0.192919293943931 0.0370269707172958 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3847349 3794109 504 R187C Transcriptional coactivator YAP1 Homo sapiens -0.00616247613698957 0.0986286301769652 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093271 3794109 504 R187C Transcriptional coactivator YAP1 Homo sapiens -0.127328697475534 0.0622173117338045 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094225 3794109 504 R187C Transcriptional coactivator YAP1 Homo sapiens -0.0754078237069973 0.0397521768649399 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3847350 3794110 504 R187D Transcriptional coactivator YAP1 Homo sapiens 0.292410472566393 0.0658723243952151 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093272 3794110 504 R187D Transcriptional coactivator YAP1 Homo sapiens -0.232731053563351 0.0613564154748931 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094226 3794110 504 R187D Transcriptional coactivator YAP1 Homo sapiens -0.314654736260694 0.0866016332066006 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3847351 3794111 504 R187E Transcriptional coactivator YAP1 Homo sapiens 0.0981491593544937 0.0825217008624783 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093273 3794111 504 R187E Transcriptional coactivator YAP1 Homo sapiens -0.190320788284861 0.0614625698606161 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094227 3794111 504 R187E Transcriptional coactivator YAP1 Homo sapiens -0.190634380187998 0.0730078137990896 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3847352 3794112 504 R187F Transcriptional coactivator YAP1 Homo sapiens 0.201704999550034 0.0622783491143851 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093274 3794112 504 R187F Transcriptional coactivator YAP1 Homo sapiens -0.322993464913234 0.0892004323742536 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094228 3794112 504 R187F Transcriptional coactivator YAP1 Homo sapiens -0.425193817685321 0.130268007662044 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3847353 3794113 504 R187G Transcriptional coactivator YAP1 Homo sapiens 0.241082709730754 0.0833979523858073 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093275 3794113 504 R187G Transcriptional coactivator YAP1 Homo sapiens -0.401572947215453 0.039696526091563 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094229 3794113 504 R187G Transcriptional coactivator YAP1 Homo sapiens -0.280033048329204 0.0440264822496521 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3847354 3794114 504 R187H Transcriptional coactivator YAP1 Homo sapiens 0.0835180130770527 0.0765930698552811 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093276 3794114 504 R187H Transcriptional coactivator YAP1 Homo sapiens -0.6737762015791 0.149468246879392 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094230 3794114 504 R187H Transcriptional coactivator YAP1 Homo sapiens -0.263889112086519 0.0765621870834442 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3847355 3794115 504 R187I Transcriptional coactivator YAP1 Homo sapiens -0.100441603553971 0.104775790681977 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093277 3794115 504 R187I Transcriptional coactivator YAP1 Homo sapiens -0.0562876414582611 0.0481943957011114 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094231 3794115 504 R187I Transcriptional coactivator YAP1 Homo sapiens -0.201813731796589 0.0989778714004967 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3847356 3794116 504 R187K Transcriptional coactivator YAP1 Homo sapiens -0.116169864684577 0.0956443184366201 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093278 3794116 504 R187K Transcriptional coactivator YAP1 Homo sapiens -0.331949651985777 0.0852396946159218 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094232 3794116 504 R187K Transcriptional coactivator YAP1 Homo sapiens -0.0652518639915717 0.0505054033975725 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3847357 3794117 504 R187L Transcriptional coactivator YAP1 Homo sapiens 0.00478946610491247 0.0757361394003222 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093279 3794117 504 R187L Transcriptional coactivator YAP1 Homo sapiens -0.173586859807216 0.059828504464264 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094233 3794117 504 R187L Transcriptional coactivator YAP1 Homo sapiens -0.08298049848434 0.041181027554561 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3847358 3794118 504 R187M Transcriptional coactivator YAP1 Homo sapiens -0.0142414976051991 0.0692173032052469 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093280 3794118 504 R187M Transcriptional coactivator YAP1 Homo sapiens -0.0495215503338223 0.0712215648856318 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094234 3794118 504 R187M Transcriptional coactivator YAP1 Homo sapiens -0.232940720680155 0.067295678240486 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3847359 3794119 504 R187N Transcriptional coactivator YAP1 Homo sapiens 0.104737609910294 0.0628793536204431 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093281 3794119 504 R187N Transcriptional coactivator YAP1 Homo sapiens 0.0927164791274935 0.0733244123425047 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094235 3794119 504 R187N Transcriptional coactivator YAP1 Homo sapiens -0.071930842662763 0.087774352434871 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3847360 3794120 504 R187P Transcriptional coactivator YAP1 Homo sapiens 0.0430623099368669 0.0637163632324575 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093282 3794120 504 R187P Transcriptional coactivator YAP1 Homo sapiens -0.255399271823556 0.074700184204474 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094236 3794120 504 R187P Transcriptional coactivator YAP1 Homo sapiens -0.0725523902322276 0.0549653296761484 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3847361 3794121 504 R187Q Transcriptional coactivator YAP1 Homo sapiens -0.0561706386976036 0.0744498671242754 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093283 3794121 504 R187Q Transcriptional coactivator YAP1 Homo sapiens -0.0756025472469328 0.0601908928239418 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094237 3794121 504 R187Q Transcriptional coactivator YAP1 Homo sapiens -0.00534658479366145 0.066676490709113 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3847362 3794122 504 R187S Transcriptional coactivator YAP1 Homo sapiens 0.0252573119007854 0.0563055092071845 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093764 3794122 504 R187S Transcriptional coactivator YAP1 Homo sapiens -0.0647100832931201 0.0494376377503271 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094698 3794122 504 R187S Transcriptional coactivator YAP1 Homo sapiens -0.125604345602632 0.0597435421730214 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3847363 3794123 504 R187T Transcriptional coactivator YAP1 Homo sapiens -0.0975591634688123 0.0890467193493199 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093765 3794123 504 R187T Transcriptional coactivator YAP1 Homo sapiens -0.0578838007899749 0.0687878243892885 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094699 3794123 504 R187T Transcriptional coactivator YAP1 Homo sapiens -0.00848550632747995 0.0626741566810508 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3847364 3794124 504 R187V Transcriptional coactivator YAP1 Homo sapiens -0.0731272505345291 0.10119303219844 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093766 3794124 504 R187V Transcriptional coactivator YAP1 Homo sapiens -0.0855986672961574 0.0554083469429908 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094700 3794124 504 R187V Transcriptional coactivator YAP1 Homo sapiens 0.00958260511599912 0.033524532445359 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3847365 3794125 504 R187W Transcriptional coactivator YAP1 Homo sapiens 0.246504413068175 0.085292704407119 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093767 3794125 504 R187W Transcriptional coactivator YAP1 Homo sapiens -0.245926019052007 0.0449395722794828 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094701 3794125 504 R187W Transcriptional coactivator YAP1 Homo sapiens -0.22982447819106 0.0347237578071504 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3847366 3794126 504 R187Y Transcriptional coactivator YAP1 Homo sapiens 0.176485423935084 0.158714215825678 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093768 3794126 504 R187Y Transcriptional coactivator YAP1 Homo sapiens -0.58344373616677 0.141781952858083 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094702 3794126 504 R187Y Transcriptional coactivator YAP1 Homo sapiens -0.8774170169767 0.0643568000555353 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093269 4905674 503 187R Transcriptional coactivator YAP1 Homo sapiens -1.07370599667561 0.0801353931819064 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094223 4905674 503 187R Transcriptional coactivator YAP1 Homo sapiens -1.05799153990129 0.0952455384870742 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3848659 3795416 504 Y188A Transcriptional coactivator YAP1 Homo sapiens 0.477530050973615 0.122519947045104 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093285 3795416 504 Y188A Transcriptional coactivator YAP1 Homo sapiens -0.66520509429081 0.0677068162356193 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094239 3795416 504 Y188A Transcriptional coactivator YAP1 Homo sapiens -0.718849317716 0.0534350469589997 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3848660 3795417 504 Y188C Transcriptional coactivator YAP1 Homo sapiens 0.337744765725092 0.131708943636127 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093286 3795417 504 Y188C Transcriptional coactivator YAP1 Homo sapiens -0.37951244432098 0.0604158272809693 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094240 3795417 504 Y188C Transcriptional coactivator YAP1 Homo sapiens -0.419070475609866 0.075882382717845 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3848661 3795418 504 Y188D Transcriptional coactivator YAP1 Homo sapiens 0.603726559895345 0.0587631963656532 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093287 3795418 504 Y188D Transcriptional coactivator YAP1 Homo sapiens -0.595343499217244 0.0747471044719714 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094241 3795418 504 Y188D Transcriptional coactivator YAP1 Homo sapiens -0.659450277319536 0.0767666528460332 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3848662 3795419 504 Y188E Transcriptional coactivator YAP1 Homo sapiens 0.390020318674657 0.103165682896455 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093288 3795419 504 Y188E Transcriptional coactivator YAP1 Homo sapiens -0.545164920098991 0.0500308129095162 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094242 3795419 504 Y188E Transcriptional coactivator YAP1 Homo sapiens -0.668771931677181 0.0805503679701584 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3848663 3795420 504 Y188F Transcriptional coactivator YAP1 Homo sapiens 0.065694771991442 0.0856505098881706 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093289 3795420 504 Y188F Transcriptional coactivator YAP1 Homo sapiens -0.277034083883083 0.0762187474214702 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094243 3795420 504 Y188F Transcriptional coactivator YAP1 Homo sapiens -0.310887888676082 0.135374265453647 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3848664 3795421 504 Y188G Transcriptional coactivator YAP1 Homo sapiens 0.627587010315877 0.150398605793507 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093290 3795421 504 Y188G Transcriptional coactivator YAP1 Homo sapiens -0.685037573416621 0.0437096811131825 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094244 3795421 504 Y188G Transcriptional coactivator YAP1 Homo sapiens -0.759005472152286 0.041594112179804 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3848665 3795422 504 Y188H Transcriptional coactivator YAP1 Homo sapiens 0.350048381553097 0.145613912566375 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093291 3795422 504 Y188H Transcriptional coactivator YAP1 Homo sapiens -0.606591309864623 0.0817851445965888 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094245 3795422 504 Y188H Transcriptional coactivator YAP1 Homo sapiens -0.860012054975351 0.240081926631625 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3848666 3795423 504 Y188I Transcriptional coactivator YAP1 Homo sapiens 0.325907713750763 0.101899967246907 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093292 3795423 504 Y188I Transcriptional coactivator YAP1 Homo sapiens -0.569181280202747 0.114837028361206 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094246 3795423 504 Y188I Transcriptional coactivator YAP1 Homo sapiens -0.434847294816082 0.0476849523492895 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3848667 3795424 504 Y188K Transcriptional coactivator YAP1 Homo sapiens 0.449246347463427 0.0839029603268339 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093293 3795424 504 Y188K Transcriptional coactivator YAP1 Homo sapiens -0.587852210758996 0.0685134459780418 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094247 3795424 504 Y188K Transcriptional coactivator YAP1 Homo sapiens -0.728937807273372 0.174240903581335 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3848668 3795425 504 Y188L Transcriptional coactivator YAP1 Homo sapiens 0.359797058969703 0.0494493375109482 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093294 3795425 504 Y188L Transcriptional coactivator YAP1 Homo sapiens -0.648612869372191 0.0529993936915171 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094248 3795425 504 Y188L Transcriptional coactivator YAP1 Homo sapiens -0.636423959723292 0.0447194900716015 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3848669 3795426 504 Y188M Transcriptional coactivator YAP1 Homo sapiens 0.323828217657189 0.111219557155847 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093295 3795426 504 Y188M Transcriptional coactivator YAP1 Homo sapiens -0.708005080616489 0.0894496826978838 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094249 3795426 504 Y188M Transcriptional coactivator YAP1 Homo sapiens -0.310672437751205 0.097137325177122 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3848670 3795427 504 Y188N Transcriptional coactivator YAP1 Homo sapiens 0.660553963004648 0.142035092565033 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093296 3795427 504 Y188N Transcriptional coactivator YAP1 Homo sapiens -0.870727541606711 0.130788831514338 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094250 3795427 504 Y188N Transcriptional coactivator YAP1 Homo sapiens -0.395543801589401 0.0575257442150674 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3848671 3795428 504 Y188P Transcriptional coactivator YAP1 Homo sapiens 0.796469239383912 0.147680850528148 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093297 3795428 504 Y188P Transcriptional coactivator YAP1 Homo sapiens -0.790626885377093 0.0956332953238072 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094251 3795428 504 Y188P Transcriptional coactivator YAP1 Homo sapiens -0.971387780534246 0.209958060245004 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3848672 3795429 504 Y188Q Transcriptional coactivator YAP1 Homo sapiens 0.365343173333274 0.0683433900150614 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093298 3795429 504 Y188Q Transcriptional coactivator YAP1 Homo sapiens -0.520930275597758 0.0435729959197062 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094252 3795429 504 Y188Q Transcriptional coactivator YAP1 Homo sapiens -0.737928631066106 0.134833299364967 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3848673 3795430 504 Y188R Transcriptional coactivator YAP1 Homo sapiens 0.560986893795769 0.100314480601509 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093299 3795430 504 Y188R Transcriptional coactivator YAP1 Homo sapiens -0.830669598919897 0.0439222727115887 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094253 3795430 504 Y188R Transcriptional coactivator YAP1 Homo sapiens -0.737783343435844 0.0573327597188698 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3848674 3795431 504 Y188S Transcriptional coactivator YAP1 Homo sapiens 0.488590996899318 0.124882079873828 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093300 3795431 504 Y188S Transcriptional coactivator YAP1 Homo sapiens -0.667673593495363 0.062039718158728 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094254 3795431 504 Y188S Transcriptional coactivator YAP1 Homo sapiens -0.795904915766219 0.0923428333784581 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3848675 3795432 504 Y188T Transcriptional coactivator YAP1 Homo sapiens 0.451346379928449 0.0872975268782674 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093301 3795432 504 Y188T Transcriptional coactivator YAP1 Homo sapiens -0.635204260748995 0.0861580119997243 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094255 3795432 504 Y188T Transcriptional coactivator YAP1 Homo sapiens -0.688944445854994 0.129780691688539 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3848676 3795433 504 Y188V Transcriptional coactivator YAP1 Homo sapiens 0.31705789924641 0.0629177166875878 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093302 3795433 504 Y188V Transcriptional coactivator YAP1 Homo sapiens -0.435931346496661 0.0506719091085235 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094256 3795433 504 Y188V Transcriptional coactivator YAP1 Homo sapiens -0.387140506799045 0.0523677711142925 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3848677 3795434 504 Y188W Transcriptional coactivator YAP1 Homo sapiens 0.418485755006148 0.096210435867391 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093303 3795434 504 Y188W Transcriptional coactivator YAP1 Homo sapiens -0.805478491655104 0.0588547094844252 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094257 3795434 504 Y188W Transcriptional coactivator YAP1 Homo sapiens -0.813286631746726 0.0536770465406067 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093284 4905675 503 188Y Transcriptional coactivator YAP1 Homo sapiens -1.30100353097131 0.177535921888473 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094238 4905675 503 188Y Transcriptional coactivator YAP1 Homo sapiens -1.21305916092814 0.175205542574263 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3849970 3796725 504 F189A Transcriptional coactivator YAP1 Homo sapiens 0.64078823999464 0.0240387432589586 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093305 3796725 504 F189A Transcriptional coactivator YAP1 Homo sapiens -0.672986099083915 0.0459008140934734 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094259 3796725 504 F189A Transcriptional coactivator YAP1 Homo sapiens -0.714880484889316 0.0401843189749525 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3849971 3796726 504 F189C Transcriptional coactivator YAP1 Homo sapiens 0.914327531385669 0.10025104853255 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093306 3796726 504 F189C Transcriptional coactivator YAP1 Homo sapiens -0.704232821645214 0.113863958578701 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094260 3796726 504 F189C Transcriptional coactivator YAP1 Homo sapiens -0.727946095170804 0.133849454056038 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3849972 3796727 504 F189D Transcriptional coactivator YAP1 Homo sapiens 0.541326688350179 0.114173920677578 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093307 3796727 504 F189D Transcriptional coactivator YAP1 Homo sapiens -0.642382481518237 0.111203934758289 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094261 3796727 504 F189D Transcriptional coactivator YAP1 Homo sapiens -0.664450156216981 0.13522890695137 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3849973 3796728 504 F189E Transcriptional coactivator YAP1 Homo sapiens 0.627813979418397 0.101890193059378 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093308 3796728 504 F189E Transcriptional coactivator YAP1 Homo sapiens -0.855520080997 0.0976717525094112 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094262 3796728 504 F189E Transcriptional coactivator YAP1 Homo sapiens -0.970077144365249 0.120418711154495 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3849974 3796729 504 F189G Transcriptional coactivator YAP1 Homo sapiens 0.64212480331248 0.0701089361894699 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093749 3796729 504 F189G Transcriptional coactivator YAP1 Homo sapiens -0.722640215490357 0.0401827128880953 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094683 3796729 504 F189G Transcriptional coactivator YAP1 Homo sapiens -0.715300259832752 0.0495553215164761 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3849975 3796730 504 F189H Transcriptional coactivator YAP1 Homo sapiens 0.734065620654258 0.218673916330619 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093750 3796730 504 F189H Transcriptional coactivator YAP1 Homo sapiens -0.969615232485719 0.133713262282656 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094684 3796730 504 F189H Transcriptional coactivator YAP1 Homo sapiens -0.954419957119951 0.172376544361 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3849976 3796731 504 F189I Transcriptional coactivator YAP1 Homo sapiens 0.841007283970758 0.246857087269566 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093751 3796731 504 F189I Transcriptional coactivator YAP1 Homo sapiens -0.698726833408002 0.0591234458604148 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094685 3796731 504 F189I Transcriptional coactivator YAP1 Homo sapiens -1.01239135165104 0.392472775445724 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3849977 3796732 504 F189K Transcriptional coactivator YAP1 Homo sapiens 0.672237290392486 0.0908172358882591 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093752 3796732 504 F189K Transcriptional coactivator YAP1 Homo sapiens -0.673600848863785 0.0436499973726101 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094686 3796732 504 F189K Transcriptional coactivator YAP1 Homo sapiens -0.945248197073528 0.126772316405913 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3849978 3796733 504 F189L Transcriptional coactivator YAP1 Homo sapiens 0.843511370950611 0.0539496014308906 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093753 3796733 504 F189L Transcriptional coactivator YAP1 Homo sapiens -0.69801766293527 0.0405141208176728 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094687 3796733 504 F189L Transcriptional coactivator YAP1 Homo sapiens -0.774142954913333 0.0713056806205454 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3849979 3796734 504 F189M Transcriptional coactivator YAP1 Homo sapiens 0.955222311149649 0.11663873536354 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093754 3796734 504 F189M Transcriptional coactivator YAP1 Homo sapiens -0.875684845541163 0.0427454297302566 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094688 3796734 504 F189M Transcriptional coactivator YAP1 Homo sapiens -0.714428604923192 0.0694019307344058 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3849980 3796735 504 F189N Transcriptional coactivator YAP1 Homo sapiens 0.856673553391607 0.105344282454872 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093755 3796735 504 F189N Transcriptional coactivator YAP1 Homo sapiens -0.547472498015171 0.123895395738082 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094689 3796735 504 F189N Transcriptional coactivator YAP1 Homo sapiens -0.772459390202656 0.0526774038595872 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3849981 3796736 504 F189P Transcriptional coactivator YAP1 Homo sapiens 0.711373492844983 0.0900840199107424 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093756 3796736 504 F189P Transcriptional coactivator YAP1 Homo sapiens -0.776205466157499 0.0632373307917004 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094690 3796736 504 F189P Transcriptional coactivator YAP1 Homo sapiens -0.679089479586264 0.0442623939251911 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3849982 3796737 504 F189Q Transcriptional coactivator YAP1 Homo sapiens 0.624173696589194 0.0883498668152733 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093757 3796737 504 F189Q Transcriptional coactivator YAP1 Homo sapiens -0.638141454990388 0.0710684539725447 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094691 3796737 504 F189Q Transcriptional coactivator YAP1 Homo sapiens -0.741239488107738 0.0451800660339367 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3849983 3796738 504 F189R Transcriptional coactivator YAP1 Homo sapiens 0.806656855014795 0.0793560276434368 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093758 3796738 504 F189R Transcriptional coactivator YAP1 Homo sapiens -0.885445348976633 0.06099099579036 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094692 3796738 504 F189R Transcriptional coactivator YAP1 Homo sapiens -0.814856305129679 0.0424218547890178 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3849984 3796739 504 F189S Transcriptional coactivator YAP1 Homo sapiens 0.613730417199795 0.0928232173984535 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093759 3796739 504 F189S Transcriptional coactivator YAP1 Homo sapiens -0.594996854891683 0.0665089932954201 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094693 3796739 504 F189S Transcriptional coactivator YAP1 Homo sapiens -0.785027975044617 0.0489805636511575 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3849985 3796740 504 F189T Transcriptional coactivator YAP1 Homo sapiens 0.751459330871635 0.0718225157792307 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093760 3796740 504 F189T Transcriptional coactivator YAP1 Homo sapiens -0.827756263670786 0.0930550012429157 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094694 3796740 504 F189T Transcriptional coactivator YAP1 Homo sapiens -0.656136514525299 0.0594893951280841 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3849986 3796741 504 F189V Transcriptional coactivator YAP1 Homo sapiens 0.791873480774098 0.0764733692538363 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093761 3796741 504 F189V Transcriptional coactivator YAP1 Homo sapiens -0.700297320754099 0.0478837574231743 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094695 3796741 504 F189V Transcriptional coactivator YAP1 Homo sapiens -0.905376097672409 0.0570385841599949 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3849987 3796742 504 F189W Transcriptional coactivator YAP1 Homo sapiens 0.0523744651167023 0.0719373180341049 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093762 3796742 504 F189W Transcriptional coactivator YAP1 Homo sapiens -0.310185029603498 0.0361713273479703 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094696 3796742 504 F189W Transcriptional coactivator YAP1 Homo sapiens -0.336284875166122 0.0742061178246891 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3849988 3796743 504 F189Y Transcriptional coactivator YAP1 Homo sapiens -0.118485523423395 0.0742272686117123 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093763 3796743 504 F189Y Transcriptional coactivator YAP1 Homo sapiens -0.315027172201341 0.0891524243107554 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094697 3796743 504 F189Y Transcriptional coactivator YAP1 Homo sapiens -0.135669589139161 0.109148572494993 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093304 4905676 503 189F Transcriptional coactivator YAP1 Homo sapiens -1.20584565326363 0.176482065122982 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094258 4905676 503 189F Transcriptional coactivator YAP1 Homo sapiens -0.993563775697373 0.0749020101376393 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 372 197 504 L190Y Transcriptional coactivator YAP1 Homo sapiens 26.7 2.9 yes 54.5 potassium phosphate 20 mM NaCl 100 mM Fluorescence Thermal 7.0 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 11420447 10.1110/ps.640101 2001 ProTherm 375 197 504 L190Y Transcriptional coactivator YAP1 Homo sapiens 29.5 7.1 yes 60.0 potassium 20 mM NaCl 2 M Fluorescence Thermal 7.0 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 11420447 10.1110/ps.640101 2001 ProTherm 3851299 197 504 L190Y Transcriptional coactivator YAP1 Homo sapiens 0.0906385975886807 0.136701847537722 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093748 197 504 L190Y Transcriptional coactivator YAP1 Homo sapiens -0.399952856371724 0.0939889828891285 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094682 197 504 L190Y Transcriptional coactivator YAP1 Homo sapiens -0.139349972865763 0.0853760434553176 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3851281 3798033 504 L190A Transcriptional coactivator YAP1 Homo sapiens 0.225053818627768 0.0770469630490948 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093310 3798033 504 L190A Transcriptional coactivator YAP1 Homo sapiens -0.394956971939113 0.0459264063073835 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094264 3798033 504 L190A Transcriptional coactivator YAP1 Homo sapiens -0.432153449534971 0.0685577529049686 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3851282 3798034 504 L190C Transcriptional coactivator YAP1 Homo sapiens 0.136302778016068 0.0864651612994018 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093311 3798034 504 L190C Transcriptional coactivator YAP1 Homo sapiens -0.253894487355902 0.05208919126588 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094265 3798034 504 L190C Transcriptional coactivator YAP1 Homo sapiens -0.447320060694085 0.0631316922339527 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3851283 3798035 504 L190D Transcriptional coactivator YAP1 Homo sapiens 0.60457738457762 0.118341525762646 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093312 3798035 504 L190D Transcriptional coactivator YAP1 Homo sapiens -0.764098514228756 0.0776540579845452 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094266 3798035 504 L190D Transcriptional coactivator YAP1 Homo sapiens -0.780174730345715 0.26579032475453 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3851284 3798036 504 L190E Transcriptional coactivator YAP1 Homo sapiens 0.204108497694616 0.0667115755662389 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093313 3798036 504 L190E Transcriptional coactivator YAP1 Homo sapiens -0.460376298224698 0.069538512409381 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094267 3798036 504 L190E Transcriptional coactivator YAP1 Homo sapiens -0.415105895104067 0.0796858711340888 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3851285 3798037 504 L190F Transcriptional coactivator YAP1 Homo sapiens 0.194808728478645 0.0740533564907684 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093314 3798037 504 L190F Transcriptional coactivator YAP1 Homo sapiens -0.267409990066102 0.0734848259927433 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094268 3798037 504 L190F Transcriptional coactivator YAP1 Homo sapiens -0.50749954371711 0.0983443464605373 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3851286 3798038 504 L190G Transcriptional coactivator YAP1 Homo sapiens 0.590519028645069 0.0678870605886896 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093315 3798038 504 L190G Transcriptional coactivator YAP1 Homo sapiens -0.737131108614531 0.0340236119320546 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094269 3798038 504 L190G Transcriptional coactivator YAP1 Homo sapiens -0.596376522957651 0.0688801284385175 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3851287 3798039 504 L190H Transcriptional coactivator YAP1 Homo sapiens 0.314877938098434 0.053094723487796 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093316 3798039 504 L190H Transcriptional coactivator YAP1 Homo sapiens -0.401997912853065 0.102335786642071 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094270 3798039 504 L190H Transcriptional coactivator YAP1 Homo sapiens -0.69738346014079 0.195922141209406 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3851288 3798040 504 L190I Transcriptional coactivator YAP1 Homo sapiens -0.112987143464032 0.119564881348261 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093317 3798040 504 L190I Transcriptional coactivator YAP1 Homo sapiens 0.081337407762695 0.0767339276074082 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094271 3798040 504 L190I Transcriptional coactivator YAP1 Homo sapiens 0.0802930316845568 0.082708066459594 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3851289 3798041 504 L190K Transcriptional coactivator YAP1 Homo sapiens 0.027485100851262 0.160237463199582 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093318 3798041 504 L190K Transcriptional coactivator YAP1 Homo sapiens -0.146767612008287 0.0550322668576508 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094272 3798041 504 L190K Transcriptional coactivator YAP1 Homo sapiens -0.110330008981079 0.0729825833618342 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3851290 3798042 504 L190M Transcriptional coactivator YAP1 Homo sapiens -0.0110581422890211 0.0735138519468324 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093739 3798042 504 L190M Transcriptional coactivator YAP1 Homo sapiens -0.066499145115627 0.0358312533102539 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094673 3798042 504 L190M Transcriptional coactivator YAP1 Homo sapiens 0.187341666382145 0.0715975315773362 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3851291 3798043 504 L190N Transcriptional coactivator YAP1 Homo sapiens 0.444490720234898 0.0940096750323007 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093740 3798043 504 L190N Transcriptional coactivator YAP1 Homo sapiens -0.648820058250461 0.105275809153067 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094674 3798043 504 L190N Transcriptional coactivator YAP1 Homo sapiens -0.318510173863758 0.130770348502679 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3851292 3798044 504 L190P Transcriptional coactivator YAP1 Homo sapiens 0.734268722554673 0.219955475931399 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093741 3798044 504 L190P Transcriptional coactivator YAP1 Homo sapiens -0.689387379544542 0.0800548962778536 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094675 3798044 504 L190P Transcriptional coactivator YAP1 Homo sapiens -0.813269126359079 0.131286084154104 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3851293 3798045 504 L190Q Transcriptional coactivator YAP1 Homo sapiens 0.147929031170492 0.0667432916007184 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093742 3798045 504 L190Q Transcriptional coactivator YAP1 Homo sapiens -0.164474755307904 0.0834232928539301 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094676 3798045 504 L190Q Transcriptional coactivator YAP1 Homo sapiens -0.428582208711103 0.0702540745783022 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3851294 3798046 504 L190R Transcriptional coactivator YAP1 Homo sapiens 0.184323329835369 0.051940532150655 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093743 3798046 504 L190R Transcriptional coactivator YAP1 Homo sapiens -0.212714881952886 0.0398152191391876 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094677 3798046 504 L190R Transcriptional coactivator YAP1 Homo sapiens -0.284802734922701 0.0478877384451286 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3851295 3798047 504 L190S Transcriptional coactivator YAP1 Homo sapiens 0.354489650385594 0.0437086452477136 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093744 3798047 504 L190S Transcriptional coactivator YAP1 Homo sapiens -0.417103048118975 0.0357858487051841 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094678 3798047 504 L190S Transcriptional coactivator YAP1 Homo sapiens -0.480304605084567 0.054716866566795 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3851296 3798048 504 L190T Transcriptional coactivator YAP1 Homo sapiens 0.169983068600076 0.0679472867331415 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093745 3798048 504 L190T Transcriptional coactivator YAP1 Homo sapiens -0.22976282087607 0.0630780629532492 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094679 3798048 504 L190T Transcriptional coactivator YAP1 Homo sapiens -0.388260284632288 0.0469872953231717 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3851297 3798049 504 L190V Transcriptional coactivator YAP1 Homo sapiens -0.0936486444969714 0.100240020782403 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093746 3798049 504 L190V Transcriptional coactivator YAP1 Homo sapiens -0.0733167252507664 0.0432400215638878 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094680 3798049 504 L190V Transcriptional coactivator YAP1 Homo sapiens -0.101113103461253 0.0713802379800753 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3851298 3798050 504 L190W Transcriptional coactivator YAP1 Homo sapiens 0.30949687989727 0.0533975702630119 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093747 3798050 504 L190W Transcriptional coactivator YAP1 Homo sapiens -0.487308676807701 0.0393735449550045 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094681 3798050 504 L190W Transcriptional coactivator YAP1 Homo sapiens -0.556758074497366 0.0415949626439812 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093309 4905677 503 190L Transcriptional coactivator YAP1 Homo sapiens -1.05959793522395 0.129018117184376 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094263 4905677 503 190L Transcriptional coactivator YAP1 Homo sapiens -1.09811445536265 0.197034690097144 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3852592 3799342 504 N191A Transcriptional coactivator YAP1 Homo sapiens 0.879546570061715 0.119704427398849 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093320 3799342 504 N191A Transcriptional coactivator YAP1 Homo sapiens -0.995367932565815 0.0739023220978172 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094274 3799342 504 N191A Transcriptional coactivator YAP1 Homo sapiens -0.968996346140125 0.105685269749608 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3852593 3799343 504 N191C Transcriptional coactivator YAP1 Homo sapiens 0.224275878371721 0.0932724181720515 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093321 3799343 504 N191C Transcriptional coactivator YAP1 Homo sapiens -0.168742541617371 0.0619697583719355 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094275 3799343 504 N191C Transcriptional coactivator YAP1 Homo sapiens -0.0383757785534444 0.0626687066231156 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3852594 3799344 504 N191D Transcriptional coactivator YAP1 Homo sapiens 0.273067742544174 0.0656073433131066 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093322 3799344 504 N191D Transcriptional coactivator YAP1 Homo sapiens -0.399806366510294 0.0595061615013592 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094276 3799344 504 N191D Transcriptional coactivator YAP1 Homo sapiens -0.332325255701357 0.10011387892512 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3852595 3799345 504 N191E Transcriptional coactivator YAP1 Homo sapiens 0.497676906532078 0.0910729964209077 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093323 3799345 504 N191E Transcriptional coactivator YAP1 Homo sapiens -0.677860803042046 0.0505393430359032 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094277 3799345 504 N191E Transcriptional coactivator YAP1 Homo sapiens -1.02281782984682 0.135540035096176 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3852596 3799346 504 N191F Transcriptional coactivator YAP1 Homo sapiens 1.09198410238639 0.209626930154756 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093324 3799346 504 N191F Transcriptional coactivator YAP1 Homo sapiens -1.15472214201943 0.162945966808501 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094278 3799346 504 N191F Transcriptional coactivator YAP1 Homo sapiens -1.13444139484134 0.106810008623884 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3852597 3799347 504 N191G Transcriptional coactivator YAP1 Homo sapiens 0.912802663607662 0.153737921066142 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093325 3799347 504 N191G Transcriptional coactivator YAP1 Homo sapiens -0.917405955793334 0.0396841324691282 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094279 3799347 504 N191G Transcriptional coactivator YAP1 Homo sapiens -1.08025598333884 0.0932293005391039 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3852598 3799348 504 N191H Transcriptional coactivator YAP1 Homo sapiens 0.230078860544078 0.176159171322821 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093326 3799348 504 N191H Transcriptional coactivator YAP1 Homo sapiens -0.464789124000926 0.0963271641327958 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094280 3799348 504 N191H Transcriptional coactivator YAP1 Homo sapiens -0.789944650196731 0.151737196221948 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3852599 3799349 504 N191I Transcriptional coactivator YAP1 Homo sapiens 1.66202148198077 0.776185268381016 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093327 3799349 504 N191I Transcriptional coactivator YAP1 Homo sapiens -1.22511711973201 0.209640552895669 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094281 3799349 504 N191I Transcriptional coactivator YAP1 Homo sapiens -1.02531642272726 0.241884627199117 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3852600 3799350 504 N191K Transcriptional coactivator YAP1 Homo sapiens 0.847987129634333 0.0980918938233722 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093328 3799350 504 N191K Transcriptional coactivator YAP1 Homo sapiens -0.811650138525019 0.104025423910113 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094282 3799350 504 N191K Transcriptional coactivator YAP1 Homo sapiens -0.765629099779948 0.10453402474181 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3852601 3799351 504 N191L Transcriptional coactivator YAP1 Homo sapiens 1.2560524146894 0.329312992973768 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093329 3799351 504 N191L Transcriptional coactivator YAP1 Homo sapiens -1.16590062380169 0.101767594531032 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094283 3799351 504 N191L Transcriptional coactivator YAP1 Homo sapiens -1.23542739643131 0.106325811019028 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3852602 3799352 504 N191M Transcriptional coactivator YAP1 Homo sapiens 0.900614749133752 0.125662439483224 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093330 3799352 504 N191M Transcriptional coactivator YAP1 Homo sapiens -1.16221640378674 0.0535435310069941 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094284 3799352 504 N191M Transcriptional coactivator YAP1 Homo sapiens -1.12801544343725 0.166299410839169 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3852603 3799353 504 N191P Transcriptional coactivator YAP1 Homo sapiens 1.07182333835937 0.207176946667462 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093731 3799353 504 N191P Transcriptional coactivator YAP1 Homo sapiens -0.969695874429239 0.119210258363008 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094665 3799353 504 N191P Transcriptional coactivator YAP1 Homo sapiens -0.974016281817747 0.167703243707579 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3852604 3799354 504 N191Q Transcriptional coactivator YAP1 Homo sapiens 0.487953300367847 0.0954278437012305 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093732 3799354 504 N191Q Transcriptional coactivator YAP1 Homo sapiens -0.970450949893201 0.182612085665937 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094666 3799354 504 N191Q Transcriptional coactivator YAP1 Homo sapiens -0.737405382981117 0.108570894702666 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3852605 3799355 504 N191R Transcriptional coactivator YAP1 Homo sapiens 0.78826835171169 0.0890755265333779 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093733 3799355 504 N191R Transcriptional coactivator YAP1 Homo sapiens -0.586443877536739 0.0446281435364518 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094667 3799355 504 N191R Transcriptional coactivator YAP1 Homo sapiens -0.618462298045986 0.042052526545689 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3852606 3799356 504 N191S Transcriptional coactivator YAP1 Homo sapiens 0.352674955329229 0.0605605823554103 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093734 3799356 504 N191S Transcriptional coactivator YAP1 Homo sapiens -0.393186040049951 0.0383398341714463 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094668 3799356 504 N191S Transcriptional coactivator YAP1 Homo sapiens -0.409874122974321 0.056026064033893 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3852607 3799357 504 N191T Transcriptional coactivator YAP1 Homo sapiens 0.927458656081353 0.139222689946115 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093735 3799357 504 N191T Transcriptional coactivator YAP1 Homo sapiens -0.83967814523994 0.0793610999885985 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094669 3799357 504 N191T Transcriptional coactivator YAP1 Homo sapiens -0.911623465773698 0.0492939384388316 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3852608 3799358 504 N191V Transcriptional coactivator YAP1 Homo sapiens 1.43615391666739 0.143639067571137 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093736 3799358 504 N191V Transcriptional coactivator YAP1 Homo sapiens -1.37525744324051 0.109251703535675 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094670 3799358 504 N191V Transcriptional coactivator YAP1 Homo sapiens -1.15450974133185 0.15580780126183 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3852609 3799359 504 N191W Transcriptional coactivator YAP1 Homo sapiens 1.00587518692909 0.170015037822696 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093737 3799359 504 N191W Transcriptional coactivator YAP1 Homo sapiens -0.789755270701588 0.0917561002983302 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094671 3799359 504 N191W Transcriptional coactivator YAP1 Homo sapiens -1.06668448861598 0.0689984067439541 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3852610 3799360 504 N191Y Transcriptional coactivator YAP1 Homo sapiens 0.776290144535477 0.204409937869048 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093738 3799360 504 N191Y Transcriptional coactivator YAP1 Homo sapiens -0.60987348047771 0.141982687480082 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094672 3799360 504 N191Y Transcriptional coactivator YAP1 Homo sapiens -0.628727188048101 0.121141818321114 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093319 4905678 503 191N Transcriptional coactivator YAP1 Homo sapiens -1.31921653567113 0.171826588318861 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094273 4905678 503 191N Transcriptional coactivator YAP1 Homo sapiens -1.1133431504067 0.249514424820358 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3853903 3800651 504 H192A Transcriptional coactivator YAP1 Homo sapiens 0.0985085177228109 0.0500016983860507 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093332 3800651 504 H192A Transcriptional coactivator YAP1 Homo sapiens -0.238011940548149 0.0469332340257774 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094286 3800651 504 H192A Transcriptional coactivator YAP1 Homo sapiens -0.215545893376916 0.0617228274524946 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3853904 3800652 504 H192C Transcriptional coactivator YAP1 Homo sapiens 0.130862327503398 0.0634017786550185 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093333 3800652 504 H192C Transcriptional coactivator YAP1 Homo sapiens -0.29693277352547 0.0774941519724403 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094287 3800652 504 H192C Transcriptional coactivator YAP1 Homo sapiens -0.476180562545554 0.124624894358618 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3853905 3800653 504 H192D Transcriptional coactivator YAP1 Homo sapiens 0.282841817544537 0.0697914123790326 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093334 3800653 504 H192D Transcriptional coactivator YAP1 Homo sapiens -0.53990071265287 0.0724633420362331 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094288 3800653 504 H192D Transcriptional coactivator YAP1 Homo sapiens -0.632226848137059 0.131680203428196 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3853906 3800654 504 H192E Transcriptional coactivator YAP1 Homo sapiens 0.144639588335257 0.12833105374359 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093335 3800654 504 H192E Transcriptional coactivator YAP1 Homo sapiens -0.44439947576355 0.055767290615333 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094289 3800654 504 H192E Transcriptional coactivator YAP1 Homo sapiens -0.6930482898698 0.094254889464728 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3853907 3800655 504 H192F Transcriptional coactivator YAP1 Homo sapiens 0.330813959791252 0.0887979873194692 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093336 3800655 504 H192F Transcriptional coactivator YAP1 Homo sapiens -0.773669523600902 0.1563900378714 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094290 3800655 504 H192F Transcriptional coactivator YAP1 Homo sapiens -0.510083962607429 0.0989082750820003 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3853908 3800656 504 H192G Transcriptional coactivator YAP1 Homo sapiens 0.198240676852516 0.0689905535324498 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093337 3800656 504 H192G Transcriptional coactivator YAP1 Homo sapiens -0.435134354626805 0.0345640797490225 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094291 3800656 504 H192G Transcriptional coactivator YAP1 Homo sapiens -0.460037335023017 0.0380901855955571 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3853909 3800657 504 H192I Transcriptional coactivator YAP1 Homo sapiens 0.0529326436926478 0.0711045856137548 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093718 3800657 504 H192I Transcriptional coactivator YAP1 Homo sapiens -0.369464835261055 0.0690219108366687 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094652 3800657 504 H192I Transcriptional coactivator YAP1 Homo sapiens -0.576231365377536 0.121253016512276 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3853910 3800658 504 H192K Transcriptional coactivator YAP1 Homo sapiens -0.0754788844950006 0.0710230320255744 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093719 3800658 504 H192K Transcriptional coactivator YAP1 Homo sapiens 0.0157447593143293 0.0627847786475102 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094653 3800658 504 H192K Transcriptional coactivator YAP1 Homo sapiens -0.163593162955474 0.0567242809489274 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3853911 3800659 504 H192L Transcriptional coactivator YAP1 Homo sapiens 0.0922367616456254 0.0700112697079877 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093720 3800659 504 H192L Transcriptional coactivator YAP1 Homo sapiens -0.211937470411042 0.0507968316012454 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094654 3800659 504 H192L Transcriptional coactivator YAP1 Homo sapiens -0.300761695206857 0.0487701871625374 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3853912 3800660 504 H192M Transcriptional coactivator YAP1 Homo sapiens 0.0331002241745806 0.0795426329298562 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093721 3800660 504 H192M Transcriptional coactivator YAP1 Homo sapiens -0.315901034988581 0.0548684085200766 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094655 3800660 504 H192M Transcriptional coactivator YAP1 Homo sapiens -0.0904234774746677 0.0797189683649828 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3853913 3800661 504 H192N Transcriptional coactivator YAP1 Homo sapiens 0.020378234635761 0.140367764259614 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093722 3800661 504 H192N Transcriptional coactivator YAP1 Homo sapiens -0.398496660125435 0.112193031401871 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094656 3800661 504 H192N Transcriptional coactivator YAP1 Homo sapiens -0.202234002844129 0.0401753607522866 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3853914 3800662 504 H192P Transcriptional coactivator YAP1 Homo sapiens 0.233436697935837 0.0491128077107163 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093723 3800662 504 H192P Transcriptional coactivator YAP1 Homo sapiens -0.454925715063789 0.0643564408132879 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094657 3800662 504 H192P Transcriptional coactivator YAP1 Homo sapiens -0.4530380148451 0.0645229027965335 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3853915 3800663 504 H192Q Transcriptional coactivator YAP1 Homo sapiens 0.0991280747305706 0.0833244423035505 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093724 3800663 504 H192Q Transcriptional coactivator YAP1 Homo sapiens -0.292246548354396 0.0738102945561568 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094658 3800663 504 H192Q Transcriptional coactivator YAP1 Homo sapiens -0.310657554628105 0.072261673227673 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3853916 3800664 504 H192R Transcriptional coactivator YAP1 Homo sapiens 0.0354710981832171 0.106418941207839 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093725 3800664 504 H192R Transcriptional coactivator YAP1 Homo sapiens -0.20051778799555 0.0377698145631257 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094659 3800664 504 H192R Transcriptional coactivator YAP1 Homo sapiens -0.222776256322958 0.0358150805264664 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3853917 3800665 504 H192S Transcriptional coactivator YAP1 Homo sapiens 0.0488266038359777 0.0712682644326743 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093726 3800665 504 H192S Transcriptional coactivator YAP1 Homo sapiens -0.183912944643323 0.0388765237103051 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094660 3800665 504 H192S Transcriptional coactivator YAP1 Homo sapiens -0.369319738687086 0.0424672908376819 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3853918 3800666 504 H192T Transcriptional coactivator YAP1 Homo sapiens 0.0110468214032705 0.0794874649218239 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093727 3800666 504 H192T Transcriptional coactivator YAP1 Homo sapiens -0.171235770051006 0.047798401696985 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094661 3800666 504 H192T Transcriptional coactivator YAP1 Homo sapiens -0.181022008825798 0.0696299685291047 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3853919 3800667 504 H192V Transcriptional coactivator YAP1 Homo sapiens 0.0959825372830734 0.0633975284700894 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093728 3800667 504 H192V Transcriptional coactivator YAP1 Homo sapiens -0.241780065894621 0.0515064589482977 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094662 3800667 504 H192V Transcriptional coactivator YAP1 Homo sapiens -0.221265973688375 0.0378992280389818 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3853920 3800668 504 H192W Transcriptional coactivator YAP1 Homo sapiens 0.272262604255365 0.0749239478525422 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093729 3800668 504 H192W Transcriptional coactivator YAP1 Homo sapiens -0.768984893863962 0.0774566592702824 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094663 3800668 504 H192W Transcriptional coactivator YAP1 Homo sapiens -0.542158935560453 0.0675047932072434 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3853921 3800669 504 H192Y Transcriptional coactivator YAP1 Homo sapiens 0.245250501612407 0.0771506351532847 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093730 3800669 504 H192Y Transcriptional coactivator YAP1 Homo sapiens -0.381103527271358 0.0775490494106096 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094664 3800669 504 H192Y Transcriptional coactivator YAP1 Homo sapiens -0.368759849770464 0.0527491759489369 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093331 4905679 503 192H Transcriptional coactivator YAP1 Homo sapiens -1.19881051392835 0.165546959565941 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094285 4905679 503 192H Transcriptional coactivator YAP1 Homo sapiens -1.39014542707095 0.245934537610689 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3855214 3801960 504 I193A Transcriptional coactivator YAP1 Homo sapiens -0.0349454976067115 0.101075215316765 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093339 3801960 504 I193A Transcriptional coactivator YAP1 Homo sapiens -0.527772512442247 0.190928358611126 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094293 3801960 504 I193A Transcriptional coactivator YAP1 Homo sapiens -0.0161503147240136 0.0335612228874014 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3855215 3801961 504 I193C Transcriptional coactivator YAP1 Homo sapiens 0.104648836521609 0.0785193814970651 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093340 3801961 504 I193C Transcriptional coactivator YAP1 Homo sapiens -0.0854340475013827 0.116430431943051 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094294 3801961 504 I193C Transcriptional coactivator YAP1 Homo sapiens -0.26640435989043 0.0743998110410342 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3855216 3801962 504 I193D Transcriptional coactivator YAP1 Homo sapiens 0.0331972976331723 0.0812631982617511 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093341 3801962 504 I193D Transcriptional coactivator YAP1 Homo sapiens 0.0728525989571285 0.193447694148779 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094295 3801962 504 I193D Transcriptional coactivator YAP1 Homo sapiens -0.0752313523902392 0.0775504973293033 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3855217 3801963 504 I193E Transcriptional coactivator YAP1 Homo sapiens -0.00961154846880623 0.070363865139735 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093342 3801963 504 I193E Transcriptional coactivator YAP1 Homo sapiens 0.221035070963677 0.132905464972526 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094296 3801963 504 I193E Transcriptional coactivator YAP1 Homo sapiens -0.0432156284415562 0.0606784574429586 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3855218 3801964 504 I193F Transcriptional coactivator YAP1 Homo sapiens 0.145969940104035 0.0578310679074968 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093343 3801964 504 I193F Transcriptional coactivator YAP1 Homo sapiens -0.896331793792575 0.320408353977405 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094297 3801964 504 I193F Transcriptional coactivator YAP1 Homo sapiens -0.472403084158728 0.105570457085693 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3855219 3801965 504 I193G Transcriptional coactivator YAP1 Homo sapiens 0.0123873625881285 0.0910380159473285 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093344 3801965 504 I193G Transcriptional coactivator YAP1 Homo sapiens -0.355582382699948 0.104404484556495 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094298 3801965 504 I193G Transcriptional coactivator YAP1 Homo sapiens -0.0336330233255569 0.0413290650189963 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3855220 3801966 504 I193H Transcriptional coactivator YAP1 Homo sapiens -0.0233372208103089 0.104335805956717 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093345 3801966 504 I193H Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094299 3801966 504 I193H Transcriptional coactivator YAP1 Homo sapiens 0.108570965574681 0.0839910625428344 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3855221 3801967 504 I193K Transcriptional coactivator YAP1 Homo sapiens -0.123927155480724 0.0670060243721335 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093706 3801967 504 I193K Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094640 3801967 504 I193K Transcriptional coactivator YAP1 Homo sapiens -0.0219561501733343 0.0440091540420427 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3855222 3801968 504 I193L Transcriptional coactivator YAP1 Homo sapiens 0.0233635163680068 0.0780870531811923 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093707 3801968 504 I193L Transcriptional coactivator YAP1 Homo sapiens -0.0525891350558346 0.0437930425467039 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094641 3801968 504 I193L Transcriptional coactivator YAP1 Homo sapiens -0.368934194926779 0.0392704456061982 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3855223 3801969 504 I193M Transcriptional coactivator YAP1 Homo sapiens 0.0678052166781073 0.0394263144268536 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093708 3801969 504 I193M Transcriptional coactivator YAP1 Homo sapiens -0.31975981000178 0.686788852458037 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094642 3801969 504 I193M Transcriptional coactivator YAP1 Homo sapiens -0.156213968778432 0.0710973168971445 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3855224 3801970 504 I193N Transcriptional coactivator YAP1 Homo sapiens -0.0198898302103896 0.148790591029951 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093709 3801970 504 I193N Transcriptional coactivator YAP1 Homo sapiens -0.707799994810488 0.254574577415548 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094643 3801970 504 I193N Transcriptional coactivator YAP1 Homo sapiens 0.172489018248428 0.0804963634949095 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3855225 3801971 504 I193P Transcriptional coactivator YAP1 Homo sapiens 0.245267774670035 0.0681469835343785 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093710 3801971 504 I193P Transcriptional coactivator YAP1 Homo sapiens -0.856827974388525 0.64492284777857 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094644 3801971 504 I193P Transcriptional coactivator YAP1 Homo sapiens -0.348903637394534 0.0700100409698715 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3855226 3801972 504 I193Q Transcriptional coactivator YAP1 Homo sapiens 0.0176824122151085 0.065791883709575 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093711 3801972 504 I193Q Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094645 3801972 504 I193Q Transcriptional coactivator YAP1 Homo sapiens -0.34067256160005 0.0779423486989236 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3855227 3801973 504 I193R Transcriptional coactivator YAP1 Homo sapiens -0.0422045107652638 0.0831083276579617 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093712 3801973 504 I193R Transcriptional coactivator YAP1 Homo sapiens -0.158971232741627 0.110382141139617 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094646 3801973 504 I193R Transcriptional coactivator YAP1 Homo sapiens -0.0736402756588276 0.0372181054539081 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3855228 3801974 504 I193S Transcriptional coactivator YAP1 Homo sapiens -0.00972883309274421 0.0951267748694057 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093713 3801974 504 I193S Transcriptional coactivator YAP1 Homo sapiens -0.198366127506139 0.118772891850988 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094647 3801974 504 I193S Transcriptional coactivator YAP1 Homo sapiens -0.128650424797112 0.0373933010744003 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3855229 3801975 504 I193T Transcriptional coactivator YAP1 Homo sapiens -0.0633910097194156 0.0943997918212835 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093714 3801975 504 I193T Transcriptional coactivator YAP1 Homo sapiens -0.196029541696606 0.182579596825382 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094648 3801975 504 I193T Transcriptional coactivator YAP1 Homo sapiens -0.0899734401809277 0.0727784719593191 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3855230 3801976 504 I193V Transcriptional coactivator YAP1 Homo sapiens -0.0202073731505976 0.0750428832631604 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093715 3801976 504 I193V Transcriptional coactivator YAP1 Homo sapiens -0.127575989766363 0.0907612020760775 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094649 3801976 504 I193V Transcriptional coactivator YAP1 Homo sapiens -0.0205209918743995 0.0361604682032086 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3855231 3801977 504 I193W Transcriptional coactivator YAP1 Homo sapiens 0.19391373653175 0.0833442922538155 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093716 3801977 504 I193W Transcriptional coactivator YAP1 Homo sapiens -0.638471419777271 0.186943544301312 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094650 3801977 504 I193W Transcriptional coactivator YAP1 Homo sapiens -0.226565782952293 0.0359088512891983 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3855232 3801978 504 I193Y Transcriptional coactivator YAP1 Homo sapiens 0.159399781795033 0.0813283137505284 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093717 3801978 504 I193Y Transcriptional coactivator YAP1 Homo sapiens 0.29605891073823 0.113208960346804 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094651 3801978 504 I193Y Transcriptional coactivator YAP1 Homo sapiens -0.115288923853991 0.086567827255559 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093338 4905680 503 193I Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094292 4905680 503 193I Transcriptional coactivator YAP1 Homo sapiens -1.20049994253166 0.18956662241359 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 373 198 504 D194T Transcriptional coactivator YAP1 Homo sapiens 29.2 4.9 yes 56.5 potassium phosphate 20 mM NaCl 100 mM Fluorescence Thermal 7.0 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 11420447 10.1110/ps.640101 2001 ProTherm 376 198 504 D194T Transcriptional coactivator YAP1 Homo sapiens 24.7 4.8 yes 57.7 potassium 20 mM NaCl 2 M Fluorescence Thermal 7.0 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 11420447 10.1110/ps.640101 2001 ProTherm 3856540 198 504 D194T Transcriptional coactivator YAP1 Homo sapiens -0.180886486490769 0.143657758482356 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093702 198 504 D194T Transcriptional coactivator YAP1 Homo sapiens 0.164743078321413 0.0631855154421997 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094636 198 504 D194T Transcriptional coactivator YAP1 Homo sapiens -0.0354034062543172 0.0697373892418797 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3856525 3803267 504 D194A Transcriptional coactivator YAP1 Homo sapiens 0.00658546428607188 0.102059667073528 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093347 3803267 504 D194A Transcriptional coactivator YAP1 Homo sapiens -0.117096163095488 0.0340747891079015 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094301 3803267 504 D194A Transcriptional coactivator YAP1 Homo sapiens -0.168126137019666 0.0338838110369945 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3856526 3803268 504 D194C Transcriptional coactivator YAP1 Homo sapiens 0.0300462226797083 0.0668404201980608 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093348 3803268 504 D194C Transcriptional coactivator YAP1 Homo sapiens -0.0892326311358747 0.0579829135095865 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094302 3803268 504 D194C Transcriptional coactivator YAP1 Homo sapiens -0.255551728269892 0.0985147936560404 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3856527 3803269 504 D194E Transcriptional coactivator YAP1 Homo sapiens 0.15441064758354 0.0584678405835731 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093689 3803269 504 D194E Transcriptional coactivator YAP1 Homo sapiens -0.0366376945013696 0.0628171297005714 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094623 3803269 504 D194E Transcriptional coactivator YAP1 Homo sapiens -0.0150255758497372 0.0499722190561134 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3856528 3803270 504 D194F Transcriptional coactivator YAP1 Homo sapiens 0.150083054600009 0.0948721171117718 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093690 3803270 504 D194F Transcriptional coactivator YAP1 Homo sapiens 0.0794518946947913 0.0614825345432158 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094624 3803270 504 D194F Transcriptional coactivator YAP1 Homo sapiens 0.108089744594445 0.0722516802735915 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3856529 3803271 504 D194G Transcriptional coactivator YAP1 Homo sapiens 0.0801742304403277 0.0964808408021228 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093691 3803271 504 D194G Transcriptional coactivator YAP1 Homo sapiens -0.188113287600746 0.0449098681966899 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094625 3803271 504 D194G Transcriptional coactivator YAP1 Homo sapiens -0.238232734022449 0.0401266149805331 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3856530 3803272 504 D194H Transcriptional coactivator YAP1 Homo sapiens 0.0205372412895161 0.0845601354659631 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093692 3803272 504 D194H Transcriptional coactivator YAP1 Homo sapiens -0.297995912816835 0.108451883396217 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094626 3803272 504 D194H Transcriptional coactivator YAP1 Homo sapiens -0.377176610243625 0.201155968627581 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3856531 3803273 504 D194I Transcriptional coactivator YAP1 Homo sapiens 0.293412309908847 0.124030399978276 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093693 3803273 504 D194I Transcriptional coactivator YAP1 Homo sapiens -0.289037550152291 0.0930555088810494 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094627 3803273 504 D194I Transcriptional coactivator YAP1 Homo sapiens -0.1336759593639 0.117820046989209 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3856532 3803274 504 D194K Transcriptional coactivator YAP1 Homo sapiens 0.00695928341067391 0.132191812806093 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093694 3803274 504 D194K Transcriptional coactivator YAP1 Homo sapiens -0.180917154457358 0.0591548686608887 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094628 3803274 504 D194K Transcriptional coactivator YAP1 Homo sapiens -0.138191924144549 0.0408679858653562 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3856533 3803275 504 D194L Transcriptional coactivator YAP1 Homo sapiens 3.25770924637713E-4 0.111453999247012 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093695 3803275 504 D194L Transcriptional coactivator YAP1 Homo sapiens 0.0199073920103936 0.0439268632107117 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094629 3803275 504 D194L Transcriptional coactivator YAP1 Homo sapiens 0.0779103145482511 0.0342515517471927 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3856534 3803276 504 D194M Transcriptional coactivator YAP1 Homo sapiens 0.0963281334693191 0.116557737663989 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093696 3803276 504 D194M Transcriptional coactivator YAP1 Homo sapiens 0.0117380440450341 0.0613747557154651 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094630 3803276 504 D194M Transcriptional coactivator YAP1 Homo sapiens -0.152130323287834 0.0636084553644596 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3856535 3803277 504 D194N Transcriptional coactivator YAP1 Homo sapiens -0.087753850678236 0.154041499273765 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093697 3803277 504 D194N Transcriptional coactivator YAP1 Homo sapiens 0.0461029701022459 0.0686660057411552 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094631 3803277 504 D194N Transcriptional coactivator YAP1 Homo sapiens 0.181343059052671 0.068113987784535 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3856536 3803278 504 D194P Transcriptional coactivator YAP1 Homo sapiens 0.887752116395733 0.116044193344124 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093698 3803278 504 D194P Transcriptional coactivator YAP1 Homo sapiens -0.943661145106026 0.098532634264376 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094632 3803278 504 D194P Transcriptional coactivator YAP1 Homo sapiens -0.794721565735734 0.101351587790928 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3856537 3803279 504 D194Q Transcriptional coactivator YAP1 Homo sapiens 0.0722971197629892 0.0837236356060729 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093699 3803279 504 D194Q Transcriptional coactivator YAP1 Homo sapiens -0.0424131660678253 0.0344442698975039 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094633 3803279 504 D194Q Transcriptional coactivator YAP1 Homo sapiens -0.211730852822266 0.0588243959263687 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3856538 3803280 504 D194R Transcriptional coactivator YAP1 Homo sapiens 0.0856643620926922 0.0913354906328298 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093700 3803280 504 D194R Transcriptional coactivator YAP1 Homo sapiens -0.209524738881459 0.0353640884397874 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094634 3803280 504 D194R Transcriptional coactivator YAP1 Homo sapiens -0.235438250480375 0.0443823093741688 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3856539 3803281 504 D194S Transcriptional coactivator YAP1 Homo sapiens -0.0573370652110048 0.085534966073363 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093701 3803281 504 D194S Transcriptional coactivator YAP1 Homo sapiens -0.0669806761452762 0.0568514098655642 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094635 3803281 504 D194S Transcriptional coactivator YAP1 Homo sapiens -0.10279489637156 0.0442634711798155 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3856541 3803282 504 D194V Transcriptional coactivator YAP1 Homo sapiens 0.287077430089595 0.059713383327316 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093703 3803282 504 D194V Transcriptional coactivator YAP1 Homo sapiens -0.219108221647747 0.04644946938834 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094637 3803282 504 D194V Transcriptional coactivator YAP1 Homo sapiens -0.296065006788565 0.0388740088172228 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3856542 3803283 504 D194W Transcriptional coactivator YAP1 Homo sapiens 0.30247689547372 0.156760514853426 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093704 3803283 504 D194W Transcriptional coactivator YAP1 Homo sapiens -0.204492594582158 0.0559876200692909 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094638 3803283 504 D194W Transcriptional coactivator YAP1 Homo sapiens -0.137508009202093 0.0352455884518446 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3856543 3803284 504 D194Y Transcriptional coactivator YAP1 Homo sapiens 0.12778479751589 0.0744607868474824 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093705 3803284 504 D194Y Transcriptional coactivator YAP1 Homo sapiens 0.14750876368344 0.0555477371225223 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094639 3803284 504 D194Y Transcriptional coactivator YAP1 Homo sapiens 0.0708053950683389 0.08886549797415 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093346 4905681 503 194D Transcriptional coactivator YAP1 Homo sapiens -1.19406910124017 0.172737943808259 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094300 4905681 503 194D Transcriptional coactivator YAP1 Homo sapiens -1.18891975936045 0.169474760588576 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3857836 3804575 504 Q195A Transcriptional coactivator YAP1 Homo sapiens 0.0271683028468292 0.0664662418838825 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093350 3804575 504 Q195A Transcriptional coactivator YAP1 Homo sapiens -0.207992396915121 0.0323141550208798 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094304 3804575 504 Q195A Transcriptional coactivator YAP1 Homo sapiens -0.186446552835698 0.0524506134123481 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3857837 3804576 504 Q195C Transcriptional coactivator YAP1 Homo sapiens 0.0303464025398376 0.0915702680576218 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093351 3804576 504 Q195C Transcriptional coactivator YAP1 Homo sapiens -0.120077449334777 0.0597865155386365 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094305 3804576 504 Q195C Transcriptional coactivator YAP1 Homo sapiens -0.14066535745975 0.0539793085963661 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3857838 3804577 504 Q195D Transcriptional coactivator YAP1 Homo sapiens 0.180496396708521 0.133881459927473 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093352 3804577 504 Q195D Transcriptional coactivator YAP1 Homo sapiens -0.42454429796119 0.0661743727416539 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094306 3804577 504 Q195D Transcriptional coactivator YAP1 Homo sapiens -0.489264032574762 0.0434813347121011 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3857839 3804578 504 Q195E Transcriptional coactivator YAP1 Homo sapiens 0.0364207236298469 0.10079795179661 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093353 3804578 504 Q195E Transcriptional coactivator YAP1 Homo sapiens -0.232659984224637 0.0674671965325821 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094307 3804578 504 Q195E Transcriptional coactivator YAP1 Homo sapiens -0.559224066251018 0.0711677636798182 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3857840 3804579 504 Q195F Transcriptional coactivator YAP1 Homo sapiens 0.322208128632503 0.0698724550898082 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093354 3804579 504 Q195F Transcriptional coactivator YAP1 Homo sapiens -0.366953476894075 0.0544455967185459 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094308 3804579 504 Q195F Transcriptional coactivator YAP1 Homo sapiens -0.607416965417309 0.143482165686474 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3857841 3804580 504 Q195G Transcriptional coactivator YAP1 Homo sapiens -0.0715572545022461 0.101803755753276 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093355 3804580 504 Q195G Transcriptional coactivator YAP1 Homo sapiens -0.201936999177815 0.0337343452195449 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094309 3804580 504 Q195G Transcriptional coactivator YAP1 Homo sapiens -0.248591387700095 0.0475860291910844 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3857842 3804581 504 Q195H Transcriptional coactivator YAP1 Homo sapiens -0.0490634765332977 0.104186953835342 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093356 3804581 504 Q195H Transcriptional coactivator YAP1 Homo sapiens -0.304577803818486 0.0726327191255176 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094310 3804581 504 Q195H Transcriptional coactivator YAP1 Homo sapiens -0.0392283688910338 0.0803976387783458 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3857843 3804582 504 Q195I Transcriptional coactivator YAP1 Homo sapiens 0.587251663815742 0.108065138993639 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093357 3804582 504 Q195I Transcriptional coactivator YAP1 Homo sapiens -0.827291919817948 0.102580250663298 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094311 3804582 504 Q195I Transcriptional coactivator YAP1 Homo sapiens -1.05525191129864 0.499119991051699 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3857844 3804583 504 Q195K Transcriptional coactivator YAP1 Homo sapiens -0.16094768406748 0.10444375412729 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093358 3804583 504 Q195K Transcriptional coactivator YAP1 Homo sapiens 0.102219464989728 0.0760026386159951 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094312 3804583 504 Q195K Transcriptional coactivator YAP1 Homo sapiens 0.15900136511903 0.0699599202810316 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3857845 3804584 504 Q195L Transcriptional coactivator YAP1 Homo sapiens 0.147878157233333 0.0549985689018567 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093359 3804584 504 Q195L Transcriptional coactivator YAP1 Homo sapiens -0.304524139215784 0.0326125157079555 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094313 3804584 504 Q195L Transcriptional coactivator YAP1 Homo sapiens -0.304202531523562 0.0461082201136656 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3857846 3804585 504 Q195M Transcriptional coactivator YAP1 Homo sapiens -0.00768194346821036 0.0674805023244618 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093360 3804585 504 Q195M Transcriptional coactivator YAP1 Homo sapiens -0.234142287574943 0.0383307692047737 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094314 3804585 504 Q195M Transcriptional coactivator YAP1 Homo sapiens -0.118783622901916 0.0697315564750648 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3857847 3804586 504 Q195N Transcriptional coactivator YAP1 Homo sapiens -0.139113936074613 0.15867559619455 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093361 3804586 504 Q195N Transcriptional coactivator YAP1 Homo sapiens -0.360020590382859 0.0753232012339494 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094315 3804586 504 Q195N Transcriptional coactivator YAP1 Homo sapiens -0.244080383960479 0.136406020244556 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3857848 3804587 504 Q195P Transcriptional coactivator YAP1 Homo sapiens 0.654758205133919 0.0778091943875854 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093362 3804587 504 Q195P Transcriptional coactivator YAP1 Homo sapiens -0.811574718002303 0.0411091669859831 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094316 3804587 504 Q195P Transcriptional coactivator YAP1 Homo sapiens -0.980608867502944 0.125048850750925 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3857849 3804588 504 Q195R Transcriptional coactivator YAP1 Homo sapiens -0.195533217904897 0.0946899904422489 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093683 3804588 504 Q195R Transcriptional coactivator YAP1 Homo sapiens 0.0182350869586299 0.0432004983091952 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094617 3804588 504 Q195R Transcriptional coactivator YAP1 Homo sapiens 0.0351489757213208 0.0319479277793617 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3857850 3804589 504 Q195S Transcriptional coactivator YAP1 Homo sapiens -0.00895924354423185 0.086469477875888 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093684 3804589 504 Q195S Transcriptional coactivator YAP1 Homo sapiens -0.132622638012341 0.0342320554017114 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094618 3804589 504 Q195S Transcriptional coactivator YAP1 Homo sapiens -0.170640676103429 0.0364945305319917 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3857851 3804590 504 Q195T Transcriptional coactivator YAP1 Homo sapiens 0.245023701301981 0.110195586668735 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093685 3804590 504 Q195T Transcriptional coactivator YAP1 Homo sapiens -0.441510289585654 0.066691228133433 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094619 3804590 504 Q195T Transcriptional coactivator YAP1 Homo sapiens -0.686464208826376 0.0913883999556554 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3857852 3804591 504 Q195V Transcriptional coactivator YAP1 Homo sapiens 0.493713926977394 0.0400994145374199 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093686 3804591 504 Q195V Transcriptional coactivator YAP1 Homo sapiens -0.685875321376638 0.0486794149299363 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094620 3804591 504 Q195V Transcriptional coactivator YAP1 Homo sapiens -0.680582752937304 0.0392719551801126 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3857853 3804592 504 Q195W Transcriptional coactivator YAP1 Homo sapiens 0.425794452680236 0.0558015747838763 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093687 3804592 504 Q195W Transcriptional coactivator YAP1 Homo sapiens -0.636267690119292 0.043627559767102 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094621 3804592 504 Q195W Transcriptional coactivator YAP1 Homo sapiens -0.496094748229559 0.0429030899436562 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3857854 3804593 504 Q195Y Transcriptional coactivator YAP1 Homo sapiens 0.226468172595372 0.0284968597930068 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093688 3804593 504 Q195Y Transcriptional coactivator YAP1 Homo sapiens -0.37743330356495 0.0420999460873798 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094622 3804593 504 Q195Y Transcriptional coactivator YAP1 Homo sapiens -0.226645159608827 0.107860898858778 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093349 4905682 503 195Q Transcriptional coactivator YAP1 Homo sapiens -1.13595932896098 0.194262018234913 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094303 4905682 503 195Q Transcriptional coactivator YAP1 Homo sapiens -0.788639896404959 0.0621620992871923 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3859147 3805885 504 T196A Transcriptional coactivator YAP1 Homo sapiens 0.0350811378082415 0.0757955564680031 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093364 3805885 504 T196A Transcriptional coactivator YAP1 Homo sapiens -0.395891026105059 0.0547877303166903 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094318 3805885 504 T196A Transcriptional coactivator YAP1 Homo sapiens -0.352511731666079 0.0432215391675873 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3859148 3805886 504 T196C Transcriptional coactivator YAP1 Homo sapiens -0.0998701185346082 0.0812474443329694 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093365 3805886 504 T196C Transcriptional coactivator YAP1 Homo sapiens 0.0572035656908618 0.057423256971166 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094319 3805886 504 T196C Transcriptional coactivator YAP1 Homo sapiens -0.0164033278167147 0.0555189889426723 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3859149 3805887 504 T196D Transcriptional coactivator YAP1 Homo sapiens 0.227339319845775 0.0871404151970886 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093366 3805887 504 T196D Transcriptional coactivator YAP1 Homo sapiens -0.521080391445856 0.0518334649300589 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094320 3805887 504 T196D Transcriptional coactivator YAP1 Homo sapiens -0.403148368773386 0.0452991381059387 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3859150 3805888 504 T196E Transcriptional coactivator YAP1 Homo sapiens 0.0681049655557564 0.0663437809690591 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093367 3805888 504 T196E Transcriptional coactivator YAP1 Homo sapiens -0.146898872725707 0.0626561576483858 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094321 3805888 504 T196E Transcriptional coactivator YAP1 Homo sapiens -0.28118755344968 0.0659219872399544 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3859151 3805889 504 T196F Transcriptional coactivator YAP1 Homo sapiens 0.0594997870597711 0.0769571589033552 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093368 3805889 504 T196F Transcriptional coactivator YAP1 Homo sapiens 0.0138599714437596 0.0561098158200377 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094322 3805889 504 T196F Transcriptional coactivator YAP1 Homo sapiens 0.194631561820587 0.0761755093709016 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3859152 3805890 504 T196G Transcriptional coactivator YAP1 Homo sapiens 0.314619202323807 0.0676703034078626 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093369 3805890 504 T196G Transcriptional coactivator YAP1 Homo sapiens -0.556254637727599 0.0451238449220037 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094323 3805890 504 T196G Transcriptional coactivator YAP1 Homo sapiens -0.534213403113447 0.045950728322461 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3859153 3805891 504 T196H Transcriptional coactivator YAP1 Homo sapiens 0.186138081155765 0.112144375791048 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093370 3805891 504 T196H Transcriptional coactivator YAP1 Homo sapiens -0.565527010837683 0.0977133788363719 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094324 3805891 504 T196H Transcriptional coactivator YAP1 Homo sapiens -0.192398384635429 0.102259954404135 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3859154 3805892 504 T196I Transcriptional coactivator YAP1 Homo sapiens -0.179339822027011 0.163046377448555 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093371 3805892 504 T196I Transcriptional coactivator YAP1 Homo sapiens 0.165512512692585 0.0713058835796338 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094325 3805892 504 T196I Transcriptional coactivator YAP1 Homo sapiens 0.155087103743713 0.0331191090849117 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3859155 3805893 504 T196K Transcriptional coactivator YAP1 Homo sapiens 0.0708294837576848 0.0926055206083028 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093372 3805893 504 T196K Transcriptional coactivator YAP1 Homo sapiens -0.336444425060726 0.0669918804440836 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094326 3805893 504 T196K Transcriptional coactivator YAP1 Homo sapiens -0.361606737320514 0.0506953829203441 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3859156 3805894 504 T196L Transcriptional coactivator YAP1 Homo sapiens -0.0302873309333093 0.0854318172246647 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093373 3805894 504 T196L Transcriptional coactivator YAP1 Homo sapiens -0.0889708348983697 0.0470618695288484 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094327 3805894 504 T196L Transcriptional coactivator YAP1 Homo sapiens -0.102590784969045 0.0577693171554022 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3859157 3805895 504 T196M Transcriptional coactivator YAP1 Homo sapiens -0.0459840977097193 0.07034649080685 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093374 3805895 504 T196M Transcriptional coactivator YAP1 Homo sapiens -0.047390920567091 0.0481614644901832 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094328 3805895 504 T196M Transcriptional coactivator YAP1 Homo sapiens 0.0445033729497855 0.0707215747364797 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3859158 3805896 504 T196N Transcriptional coactivator YAP1 Homo sapiens 0.115987805531892 0.106119229464451 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093375 3805896 504 T196N Transcriptional coactivator YAP1 Homo sapiens -0.250336669236234 0.0563422560694702 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094329 3805896 504 T196N Transcriptional coactivator YAP1 Homo sapiens -0.2976936456878 0.0395973994719007 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3859159 3805897 504 T196P Transcriptional coactivator YAP1 Homo sapiens 1.00055121421414 0.191016240191798 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093376 3805897 504 T196P Transcriptional coactivator YAP1 Homo sapiens -0.879657549055502 0.0444038980168913 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094330 3805897 504 T196P Transcriptional coactivator YAP1 Homo sapiens -0.924569727582327 0.186483902387478 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3859160 3805898 504 T196Q Transcriptional coactivator YAP1 Homo sapiens -0.039123306736508 0.0851605176918342 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093377 3805898 504 T196Q Transcriptional coactivator YAP1 Homo sapiens -0.360274409449693 0.0571894170908793 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094331 3805898 504 T196Q Transcriptional coactivator YAP1 Homo sapiens -0.434957146438964 0.104473925273292 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3859161 3805899 504 T196R Transcriptional coactivator YAP1 Homo sapiens 0.12348659011066 0.0846180536598484 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093378 3805899 504 T196R Transcriptional coactivator YAP1 Homo sapiens -0.340601256178119 0.031642716565426 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094332 3805899 504 T196R Transcriptional coactivator YAP1 Homo sapiens -0.394095177607661 0.0365204767765962 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3859162 3805900 504 T196S Transcriptional coactivator YAP1 Homo sapiens -0.0439604785509731 0.102997453442679 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093379 3805900 504 T196S Transcriptional coactivator YAP1 Homo sapiens -0.102020035722931 0.0546259750513842 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094333 3805900 504 T196S Transcriptional coactivator YAP1 Homo sapiens -0.117755269967716 0.0508519462881553 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3859163 3805901 504 T196V Transcriptional coactivator YAP1 Homo sapiens -0.0792827606217956 0.0984758789582171 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093680 3805901 504 T196V Transcriptional coactivator YAP1 Homo sapiens 0.0408061287761043 0.0472797550677914 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094614 3805901 504 T196V Transcriptional coactivator YAP1 Homo sapiens -0.0585381580331472 0.05540879713412 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3859164 3805902 504 T196W Transcriptional coactivator YAP1 Homo sapiens 0.141728869947935 0.141365032962722 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093681 3805902 504 T196W Transcriptional coactivator YAP1 Homo sapiens -0.119438550483691 0.0489393619142402 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094615 3805902 504 T196W Transcriptional coactivator YAP1 Homo sapiens -0.118841029233873 0.0404306063134527 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3859165 3805903 504 T196Y Transcriptional coactivator YAP1 Homo sapiens 0.111341494815178 0.155414915532149 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093682 3805903 504 T196Y Transcriptional coactivator YAP1 Homo sapiens 0.0815941276188634 0.068785518261767 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094616 3805903 504 T196Y Transcriptional coactivator YAP1 Homo sapiens 0.159262174133355 0.0722183704266533 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093363 4905683 503 196T Transcriptional coactivator YAP1 Homo sapiens -1.45349561141757 0.231771327411788 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093380 4905683 503 196T Transcriptional coactivator YAP1 Homo sapiens -1.39519269733247 0.262212863373359 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093397 4905683 503 196T Transcriptional coactivator YAP1 Homo sapiens -1.31495498605873 0.112109923787417 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094317 4905683 503 196T Transcriptional coactivator YAP1 Homo sapiens -1.07401726162335 0.0843997105799533 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094334 4905683 503 196T Transcriptional coactivator YAP1 Homo sapiens -1.07692358120472 0.207868044529666 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094351 4905683 503 196T Transcriptional coactivator YAP1 Homo sapiens -1.09464030919901 0.0719912964913551 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3860458 3807194 504 T197A Transcriptional coactivator YAP1 Homo sapiens 0.220703022357703 0.0798205941240002 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093381 3807194 504 T197A Transcriptional coactivator YAP1 Homo sapiens -0.347543570254674 0.0474312342868774 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094335 3807194 504 T197A Transcriptional coactivator YAP1 Homo sapiens -0.539784793937934 0.0593260138724527 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3860459 3807195 504 T197C Transcriptional coactivator YAP1 Homo sapiens 0.0083758075944951 0.0770904438925323 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093382 3807195 504 T197C Transcriptional coactivator YAP1 Homo sapiens -0.158256188170491 0.0482756613143381 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094336 3807195 504 T197C Transcriptional coactivator YAP1 Homo sapiens -0.145544186955981 0.0379452239765625 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3860460 3807196 504 T197D Transcriptional coactivator YAP1 Homo sapiens 0.685487312239247 0.136502132731995 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093383 3807196 504 T197D Transcriptional coactivator YAP1 Homo sapiens -1.00522844071362 0.143193041830209 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094337 3807196 504 T197D Transcriptional coactivator YAP1 Homo sapiens -0.774459114971187 0.124098457032964 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3860461 3807197 504 T197E Transcriptional coactivator YAP1 Homo sapiens 0.236654089052508 0.0316670498884861 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093384 3807197 504 T197E Transcriptional coactivator YAP1 Homo sapiens -0.698554816600423 0.0524233404413792 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094338 3807197 504 T197E Transcriptional coactivator YAP1 Homo sapiens -0.598639253772965 0.0809265566245162 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3860462 3807198 504 T197F Transcriptional coactivator YAP1 Homo sapiens 0.494609931676854 0.101641641074428 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093385 3807198 504 T197F Transcriptional coactivator YAP1 Homo sapiens -0.601599776616015 0.0423240175595802 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094339 3807198 504 T197F Transcriptional coactivator YAP1 Homo sapiens -0.580168518413621 0.055910578085838 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3860463 3807199 504 T197G Transcriptional coactivator YAP1 Homo sapiens 0.484082391274086 0.0530947910046336 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093386 3807199 504 T197G Transcriptional coactivator YAP1 Homo sapiens -0.466398336884649 0.0382343759751638 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094340 3807199 504 T197G Transcriptional coactivator YAP1 Homo sapiens -0.594268364006535 0.0621245371193683 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3860464 3807200 504 T197H Transcriptional coactivator YAP1 Homo sapiens 0.292468255726603 0.176194280078392 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093387 3807200 504 T197H Transcriptional coactivator YAP1 Homo sapiens -0.524963823168404 0.0531663921335467 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094341 3807200 504 T197H Transcriptional coactivator YAP1 Homo sapiens -0.0196598968950386 0.104486682235949 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3860465 3807201 504 T197I Transcriptional coactivator YAP1 Homo sapiens 0.427425164354044 0.0770765691823981 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093388 3807201 504 T197I Transcriptional coactivator YAP1 Homo sapiens -0.731263899585348 0.115893133238432 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094342 3807201 504 T197I Transcriptional coactivator YAP1 Homo sapiens -0.619594407609798 0.0868470629937221 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3860466 3807202 504 T197K Transcriptional coactivator YAP1 Homo sapiens 0.304521249053304 0.0833827273389204 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093389 3807202 504 T197K Transcriptional coactivator YAP1 Homo sapiens -0.713162103896672 0.109582175960692 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094343 3807202 504 T197K Transcriptional coactivator YAP1 Homo sapiens -0.41031849050688 0.0606633546166128 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3860467 3807203 504 T197L Transcriptional coactivator YAP1 Homo sapiens 0.44386397268393 0.0539083576453401 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093390 3807203 504 T197L Transcriptional coactivator YAP1 Homo sapiens -0.581481352181483 0.0577213058233883 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094344 3807203 504 T197L Transcriptional coactivator YAP1 Homo sapiens -0.637370809840516 0.0714007199923416 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3860468 3807204 504 T197M Transcriptional coactivator YAP1 Homo sapiens 0.244625847083405 0.0874998185766309 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093391 3807204 504 T197M Transcriptional coactivator YAP1 Homo sapiens -0.674172521922027 0.0872354376785644 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094345 3807204 504 T197M Transcriptional coactivator YAP1 Homo sapiens -0.464643307262413 0.0800949444032964 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3860469 3807205 504 T197N Transcriptional coactivator YAP1 Homo sapiens 0.29427862970536 0.0703327218730948 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093392 3807205 504 T197N Transcriptional coactivator YAP1 Homo sapiens -0.334388490619377 0.0898427396528083 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094346 3807205 504 T197N Transcriptional coactivator YAP1 Homo sapiens -0.860356067735007 0.198252483926803 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3860470 3807206 504 T197P Transcriptional coactivator YAP1 Homo sapiens 0.628480089285706 0.106193115390437 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093393 3807206 504 T197P Transcriptional coactivator YAP1 Homo sapiens -0.861924588730802 0.0997649620937178 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094347 3807206 504 T197P Transcriptional coactivator YAP1 Homo sapiens -0.705539624215671 0.0457031652876951 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3860471 3807207 504 T197Q Transcriptional coactivator YAP1 Homo sapiens 0.197819304268831 0.143617225874162 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093394 3807207 504 T197Q Transcriptional coactivator YAP1 Homo sapiens -0.477530841155952 0.0845052872759733 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094348 3807207 504 T197Q Transcriptional coactivator YAP1 Homo sapiens -0.641138153529231 0.124815823566387 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3860472 3807208 504 T197R Transcriptional coactivator YAP1 Homo sapiens 0.299703607609406 0.0434865531114328 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093395 3807208 504 T197R Transcriptional coactivator YAP1 Homo sapiens -0.461135579833196 0.0381628062502902 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094349 3807208 504 T197R Transcriptional coactivator YAP1 Homo sapiens -0.570217449692873 0.0572713632924814 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3860473 3807209 504 T197S Transcriptional coactivator YAP1 Homo sapiens 0.0266357052753833 0.0783429600003225 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093396 3807209 504 T197S Transcriptional coactivator YAP1 Homo sapiens -0.384595352433648 0.0540771094492908 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094350 3807209 504 T197S Transcriptional coactivator YAP1 Homo sapiens -0.517708515699578 0.0735153282968018 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3860474 3807210 504 T197V Transcriptional coactivator YAP1 Homo sapiens 0.182296361841476 0.0831007027564314 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093677 3807210 504 T197V Transcriptional coactivator YAP1 Homo sapiens -0.247486643714365 0.0438956507174646 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094611 3807210 504 T197V Transcriptional coactivator YAP1 Homo sapiens -0.315208246695987 0.0515892136833237 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3860475 3807211 504 T197W Transcriptional coactivator YAP1 Homo sapiens 0.462727490698222 0.0934849499241231 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093678 3807211 504 T197W Transcriptional coactivator YAP1 Homo sapiens -0.794150764261539 0.0761225137352738 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094612 3807211 504 T197W Transcriptional coactivator YAP1 Homo sapiens -0.653305815383682 0.059919368554445 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3860476 3807212 504 T197Y Transcriptional coactivator YAP1 Homo sapiens 0.432900070959521 0.0860641292883345 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093679 3807212 504 T197Y Transcriptional coactivator YAP1 Homo sapiens -0.931576094136764 0.143395807004742 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094613 3807212 504 T197Y Transcriptional coactivator YAP1 Homo sapiens -0.753429687262883 0.236121102342609 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3861769 3808504 504 T198A Transcriptional coactivator YAP1 Homo sapiens 0.293911338108621 0.0728125545543081 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093398 3808504 504 T198A Transcriptional coactivator YAP1 Homo sapiens -0.488159333280259 0.0448163322445752 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094352 3808504 504 T198A Transcriptional coactivator YAP1 Homo sapiens -0.539016116065823 0.0671869463954378 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3861770 3808505 504 T198C Transcriptional coactivator YAP1 Homo sapiens 0.21833183101993 0.074125396956526 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093399 3808505 504 T198C Transcriptional coactivator YAP1 Homo sapiens -0.682565230666199 0.089797559858912 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094353 3808505 504 T198C Transcriptional coactivator YAP1 Homo sapiens -0.410934368315163 0.0561062061081861 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3861771 3808506 504 T198D Transcriptional coactivator YAP1 Homo sapiens 0.667382447171051 0.0888226309652063 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093400 3808506 504 T198D Transcriptional coactivator YAP1 Homo sapiens -0.715848234821101 0.0538819878546561 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094354 3808506 504 T198D Transcriptional coactivator YAP1 Homo sapiens -0.917225969412666 0.193167275123584 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3861772 3808507 504 T198E Transcriptional coactivator YAP1 Homo sapiens 0.581618734051777 0.0795555849098761 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093401 3808507 504 T198E Transcriptional coactivator YAP1 Homo sapiens -0.655572298105824 0.0360543530180269 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094355 3808507 504 T198E Transcriptional coactivator YAP1 Homo sapiens -0.619779808800415 0.0966501509476465 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3861773 3808508 504 T198F Transcriptional coactivator YAP1 Homo sapiens 0.676405847464966 0.10485015372695 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093402 3808508 504 T198F Transcriptional coactivator YAP1 Homo sapiens -0.858627479052639 0.138418705183077 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094356 3808508 504 T198F Transcriptional coactivator YAP1 Homo sapiens -0.98073353137691 0.200004936235828 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3861774 3808509 504 T198G Transcriptional coactivator YAP1 Homo sapiens 0.52888236743254 0.0756115280742201 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093403 3808509 504 T198G Transcriptional coactivator YAP1 Homo sapiens -0.651295591869151 0.0505842617587593 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094357 3808509 504 T198G Transcriptional coactivator YAP1 Homo sapiens -0.712553402284598 0.0498727076601858 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3861775 3808510 504 T198H Transcriptional coactivator YAP1 Homo sapiens 0.247854468500736 0.0760927183254901 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093404 3808510 504 T198H Transcriptional coactivator YAP1 Homo sapiens -0.240872844030026 0.0340771822591031 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094358 3808510 504 T198H Transcriptional coactivator YAP1 Homo sapiens -0.402141986163763 0.194704134763703 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3861776 3808511 504 T198I Transcriptional coactivator YAP1 Homo sapiens 0.827935168991167 0.113901152653529 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093405 3808511 504 T198I Transcriptional coactivator YAP1 Homo sapiens -0.664639222811239 0.0787290905121838 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094359 3808511 504 T198I Transcriptional coactivator YAP1 Homo sapiens -0.938210039031522 0.0954468150089989 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3861777 3808512 504 T198K Transcriptional coactivator YAP1 Homo sapiens 0.566251451693592 0.169499411733671 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093406 3808512 504 T198K Transcriptional coactivator YAP1 Homo sapiens -0.656099371528036 0.0813935380363318 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094360 3808512 504 T198K Transcriptional coactivator YAP1 Homo sapiens -0.66962764038342 0.0511770929174814 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3861778 3808513 504 T198L Transcriptional coactivator YAP1 Homo sapiens 0.640262880228189 0.0656813451429975 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093407 3808513 504 T198L Transcriptional coactivator YAP1 Homo sapiens -0.867301491842596 0.0389057056510176 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094361 3808513 504 T198L Transcriptional coactivator YAP1 Homo sapiens -0.917507543927316 0.0806633379616893 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3861779 3808514 504 T198M Transcriptional coactivator YAP1 Homo sapiens 0.349884900783568 0.0943297881134613 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093408 3808514 504 T198M Transcriptional coactivator YAP1 Homo sapiens -0.635348284939489 0.0390295040878721 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094362 3808514 504 T198M Transcriptional coactivator YAP1 Homo sapiens -0.683920257856486 0.0842539268455874 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3861780 3808515 504 T198N Transcriptional coactivator YAP1 Homo sapiens 0.49290228456656 0.0971097376390888 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093409 3808515 504 T198N Transcriptional coactivator YAP1 Homo sapiens -0.786647219968349 0.104323407494575 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094363 3808515 504 T198N Transcriptional coactivator YAP1 Homo sapiens -0.583361302678659 0.174450188640928 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3861781 3808516 504 T198P Transcriptional coactivator YAP1 Homo sapiens 0.887657446536561 0.0504454145418715 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093410 3808516 504 T198P Transcriptional coactivator YAP1 Homo sapiens -0.757645055674922 0.118441549189171 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094364 3808516 504 T198P Transcriptional coactivator YAP1 Homo sapiens -0.843597600252319 0.0886943420584993 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3861782 3808517 504 T198Q Transcriptional coactivator YAP1 Homo sapiens 0.163244573125435 0.0616765332809949 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093411 3808517 504 T198Q Transcriptional coactivator YAP1 Homo sapiens -0.38761144814496 0.0679821374033999 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094365 3808517 504 T198Q Transcriptional coactivator YAP1 Homo sapiens -0.261195266805407 0.0769465968915145 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3861783 3808518 504 T198R Transcriptional coactivator YAP1 Homo sapiens 0.540845687146055 0.114670338226296 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093412 3808518 504 T198R Transcriptional coactivator YAP1 Homo sapiens -0.802188778989745 0.0460124074591999 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094366 3808518 504 T198R Transcriptional coactivator YAP1 Homo sapiens -0.692126811933862 0.0546161007362061 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3861784 3808519 504 T198S Transcriptional coactivator YAP1 Homo sapiens -0.054404353213823 0.0713429425562222 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093413 3808519 504 T198S Transcriptional coactivator YAP1 Homo sapiens -0.119830882241282 0.0466716553474724 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094367 3808519 504 T198S Transcriptional coactivator YAP1 Homo sapiens -0.0843306103655601 0.0603322759996511 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3861785 3808520 504 T198V Transcriptional coactivator YAP1 Homo sapiens 0.324376454378793 0.110814958005191 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093674 3808520 504 T198V Transcriptional coactivator YAP1 Homo sapiens -0.769013321599447 0.0467955770678737 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094608 3808520 504 T198V Transcriptional coactivator YAP1 Homo sapiens -0.714148447848837 0.0476265892451328 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3861786 3808521 504 T198W Transcriptional coactivator YAP1 Homo sapiens 0.65309066302518 0.0757165212578665 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093675 3808521 504 T198W Transcriptional coactivator YAP1 Homo sapiens -0.790260153085386 0.0480787629862356 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094609 3808521 504 T198W Transcriptional coactivator YAP1 Homo sapiens -0.686065766359383 0.0992522169696413 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3861787 3808522 504 T198Y Transcriptional coactivator YAP1 Homo sapiens 0.609169272222076 0.106372721431355 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093676 3808522 504 T198Y Transcriptional coactivator YAP1 Homo sapiens -1.07144794973733 0.181700657656805 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094610 3808522 504 T198Y Transcriptional coactivator YAP1 Homo sapiens -0.585389234509065 0.195997407289084 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3863080 3809813 504 W199A Transcriptional coactivator YAP1 Homo sapiens 0.1877012084751 0.0518158454307509 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093415 3809813 504 W199A Transcriptional coactivator YAP1 Homo sapiens -0.368669293785867 0.0444764540101389 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094369 3809813 504 W199A Transcriptional coactivator YAP1 Homo sapiens -0.636387389763675 0.0816539869840356 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3863081 3809814 504 W199C Transcriptional coactivator YAP1 Homo sapiens 0.184983115625553 0.0775017744719003 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093416 3809814 504 W199C Transcriptional coactivator YAP1 Homo sapiens -0.489926639182751 0.137497632049406 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094370 3809814 504 W199C Transcriptional coactivator YAP1 Homo sapiens -0.321223154588856 0.0906859165453323 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3863082 3809815 504 W199D Transcriptional coactivator YAP1 Homo sapiens 0.196617572075749 0.0498457007326929 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093417 3809815 504 W199D Transcriptional coactivator YAP1 Homo sapiens -0.445460439462913 0.0778146166742505 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094371 3809815 504 W199D Transcriptional coactivator YAP1 Homo sapiens -0.366596835879921 0.0818531373455174 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3863083 3809816 504 W199E Transcriptional coactivator YAP1 Homo sapiens 0.085326254649021 0.0692280721408498 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093418 3809816 504 W199E Transcriptional coactivator YAP1 Homo sapiens -0.27788836634231 0.0352603344572393 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094372 3809816 504 W199E Transcriptional coactivator YAP1 Homo sapiens -0.27557519860066 0.0646146040964344 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3863084 3809817 504 W199F Transcriptional coactivator YAP1 Homo sapiens -0.0970713093056677 0.100966378174496 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093419 3809817 504 W199F Transcriptional coactivator YAP1 Homo sapiens -0.0711628891693534 0.0845908605613628 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094373 3809817 504 W199F Transcriptional coactivator YAP1 Homo sapiens 0.161774587056676 0.101750668106054 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3863085 3809818 504 W199G Transcriptional coactivator YAP1 Homo sapiens 0.25982578895951 0.0578904557178814 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093420 3809818 504 W199G Transcriptional coactivator YAP1 Homo sapiens -0.454634185735598 0.0335952161110536 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094374 3809818 504 W199G Transcriptional coactivator YAP1 Homo sapiens -0.46771702654265 0.0473347595499464 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3863086 3809819 504 W199H Transcriptional coactivator YAP1 Homo sapiens 0.149513662602613 0.0908334736877105 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093421 3809819 504 W199H Transcriptional coactivator YAP1 Homo sapiens -0.447177706749372 0.115263009275085 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094375 3809819 504 W199H Transcriptional coactivator YAP1 Homo sapiens -0.193628014091554 0.0980914751118657 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3863087 3809820 504 W199I Transcriptional coactivator YAP1 Homo sapiens 0.234810688087341 0.0886202942556177 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093422 3809820 504 W199I Transcriptional coactivator YAP1 Homo sapiens -0.522085514950516 0.0669696603977757 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094376 3809820 504 W199I Transcriptional coactivator YAP1 Homo sapiens -0.885363754247958 0.704553156642195 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3863088 3809821 504 W199K Transcriptional coactivator YAP1 Homo sapiens 0.168016314372548 0.0864579595033873 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093423 3809821 504 W199K Transcriptional coactivator YAP1 Homo sapiens -0.2709126931884 0.0579428608608403 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094377 3809821 504 W199K Transcriptional coactivator YAP1 Homo sapiens -0.423748028584172 0.0532972788495034 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3863089 3809822 504 W199L Transcriptional coactivator YAP1 Homo sapiens 0.126212436143728 0.0518519388068704 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093424 3809822 504 W199L Transcriptional coactivator YAP1 Homo sapiens -0.26320021954334 0.035394923830421 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094378 3809822 504 W199L Transcriptional coactivator YAP1 Homo sapiens -0.473517900950938 0.0552148204297158 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3863090 3809823 504 W199M Transcriptional coactivator YAP1 Homo sapiens 0.0851559377996812 0.0727188749420883 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093425 3809823 504 W199M Transcriptional coactivator YAP1 Homo sapiens -0.203728961789657 0.0487859319143262 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094379 3809823 504 W199M Transcriptional coactivator YAP1 Homo sapiens -0.281537661202606 0.0562492825315881 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3863091 3809824 504 W199N Transcriptional coactivator YAP1 Homo sapiens 0.228550515648932 0.0890339474142004 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093426 3809824 504 W199N Transcriptional coactivator YAP1 Homo sapiens -0.570671560723724 0.125038161696698 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094380 3809824 504 W199N Transcriptional coactivator YAP1 Homo sapiens -0.2574716511498 0.100689288812975 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3863092 3809825 504 W199P Transcriptional coactivator YAP1 Homo sapiens 0.257633877331273 0.104949500252408 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093427 3809825 504 W199P Transcriptional coactivator YAP1 Homo sapiens -0.43471083938386 0.0548664287313553 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094381 3809825 504 W199P Transcriptional coactivator YAP1 Homo sapiens -0.280702080148559 0.140195476001876 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3863093 3809826 504 W199Q Transcriptional coactivator YAP1 Homo sapiens 0.128469373238293 0.0812304807275134 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093428 3809826 504 W199Q Transcriptional coactivator YAP1 Homo sapiens -0.310944311211996 0.0355709509792564 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094382 3809826 504 W199Q Transcriptional coactivator YAP1 Homo sapiens -0.537264514220975 0.0835078571461856 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3863094 3809827 504 W199R Transcriptional coactivator YAP1 Homo sapiens 0.18027556038542 0.058397196591074 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093429 3809827 504 W199R Transcriptional coactivator YAP1 Homo sapiens -0.447118240568 0.0406868990824528 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094383 3809827 504 W199R Transcriptional coactivator YAP1 Homo sapiens -0.442179713463381 0.0315916045507417 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3863095 3809828 504 W199S Transcriptional coactivator YAP1 Homo sapiens 0.114547615121086 0.0706404028538854 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093430 3809828 504 W199S Transcriptional coactivator YAP1 Homo sapiens -0.348148384831071 0.0580416327377051 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094384 3809828 504 W199S Transcriptional coactivator YAP1 Homo sapiens -0.198903018150305 0.0613243778983 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3863096 3809829 504 W199T Transcriptional coactivator YAP1 Homo sapiens -6.1026916651839E-4 0.0941866692968826 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093431 3809829 504 W199T Transcriptional coactivator YAP1 Homo sapiens -0.293594690197947 0.0734446500604503 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094385 3809829 504 W199T Transcriptional coactivator YAP1 Homo sapiens -0.185971001616644 0.06754678487599 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3863097 3809830 504 W199V Transcriptional coactivator YAP1 Homo sapiens 0.185752706299346 0.103798822041386 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093432 3809830 504 W199V Transcriptional coactivator YAP1 Homo sapiens -0.32048138134892 0.0368424684725173 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094386 3809830 504 W199V Transcriptional coactivator YAP1 Homo sapiens -0.4389550367917 0.0451337440850881 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3863098 3809831 504 W199Y Transcriptional coactivator YAP1 Homo sapiens -0.146254050956807 0.100057365230985 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093673 3809831 504 W199Y Transcriptional coactivator YAP1 Homo sapiens -0.0610500123493855 0.0942304736012869 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094607 3809831 504 W199Y Transcriptional coactivator YAP1 Homo sapiens -0.210763449820762 0.17066718223695 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093414 4905684 503 199W Transcriptional coactivator YAP1 Homo sapiens -0.988778862110558 0.136692590489144 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094368 4905684 503 199W Transcriptional coactivator YAP1 Homo sapiens -1.07770338598315 0.137887387097115 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3864391 3811123 504 Q200A Transcriptional coactivator YAP1 Homo sapiens -0.0247973872028095 0.0897852567789229 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093434 3811123 504 Q200A Transcriptional coactivator YAP1 Homo sapiens -0.146707420629581 0.0472331321312008 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094388 3811123 504 Q200A Transcriptional coactivator YAP1 Homo sapiens -0.151396089214897 0.038376338442361 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3864392 3811124 504 Q200C Transcriptional coactivator YAP1 Homo sapiens -0.0721147342789221 0.0909096326805638 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093435 3811124 504 Q200C Transcriptional coactivator YAP1 Homo sapiens -0.0515172933964647 0.0383660065432235 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094389 3811124 504 Q200C Transcriptional coactivator YAP1 Homo sapiens -0.252615500698293 0.0966817598662305 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3864393 3811125 504 Q200D Transcriptional coactivator YAP1 Homo sapiens 0.0104234868284451 0.0620251272148316 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093436 3811125 504 Q200D Transcriptional coactivator YAP1 Homo sapiens -0.272006290767784 0.0745448469355721 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094390 3811125 504 Q200D Transcriptional coactivator YAP1 Homo sapiens -0.166579709657554 0.0943205169503978 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3864394 3811126 504 Q200E Transcriptional coactivator YAP1 Homo sapiens -0.131849502439279 0.112033096789818 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093437 3811126 504 Q200E Transcriptional coactivator YAP1 Homo sapiens -0.196343552142145 0.0623548018963214 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094391 3811126 504 Q200E Transcriptional coactivator YAP1 Homo sapiens -0.484208944377818 0.110028802918339 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3864395 3811127 504 Q200F Transcriptional coactivator YAP1 Homo sapiens -0.00892060253277218 0.111868524498081 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093438 3811127 504 Q200F Transcriptional coactivator YAP1 Homo sapiens -0.0276662782848173 0.0806645696763869 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094392 3811127 504 Q200F Transcriptional coactivator YAP1 Homo sapiens -0.328505962825821 0.0922372340764624 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3864396 3811128 504 Q200G Transcriptional coactivator YAP1 Homo sapiens 0.138582793491018 0.0770440148138513 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093439 3811128 504 Q200G Transcriptional coactivator YAP1 Homo sapiens -0.357066136444921 0.0350329633371702 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094393 3811128 504 Q200G Transcriptional coactivator YAP1 Homo sapiens -0.434249843731637 0.0579934924252965 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3864397 3811129 504 Q200H Transcriptional coactivator YAP1 Homo sapiens -0.140356984071205 0.0919784129675341 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093440 3811129 504 Q200H Transcriptional coactivator YAP1 Homo sapiens 0.0210553793898135 0.11059049033362 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094394 3811129 504 Q200H Transcriptional coactivator YAP1 Homo sapiens 0.0494013378900022 0.0608543972196058 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3864398 3811130 504 Q200I Transcriptional coactivator YAP1 Homo sapiens -0.111510331920493 0.181367825279081 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093441 3811130 504 Q200I Transcriptional coactivator YAP1 Homo sapiens -0.249150971595456 0.0950887446458499 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094395 3811130 504 Q200I Transcriptional coactivator YAP1 Homo sapiens 0.0421837319066184 0.0688069247344696 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3864399 3811131 504 Q200K Transcriptional coactivator YAP1 Homo sapiens -0.121930975164793 0.087160118860872 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093442 3811131 504 Q200K Transcriptional coactivator YAP1 Homo sapiens -0.119585040345121 0.0530941697310726 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094396 3811131 504 Q200K Transcriptional coactivator YAP1 Homo sapiens -0.0144685218137063 0.0958891981251446 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3864400 3811132 504 Q200L Transcriptional coactivator YAP1 Homo sapiens 0.0362992192035567 0.0958620939964147 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093443 3811132 504 Q200L Transcriptional coactivator YAP1 Homo sapiens -0.195030944967951 0.0495699282479605 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094397 3811132 504 Q200L Transcriptional coactivator YAP1 Homo sapiens -0.0185323231401717 0.0404708757922406 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3864401 3811133 504 Q200M Transcriptional coactivator YAP1 Homo sapiens -0.0545384427786485 0.0711828556330649 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093444 3811133 504 Q200M Transcriptional coactivator YAP1 Homo sapiens -0.0633496130948941 0.0516116053097266 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094398 3811133 504 Q200M Transcriptional coactivator YAP1 Homo sapiens -0.0198803088609491 0.0595465675823928 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3864402 3811134 504 Q200N Transcriptional coactivator YAP1 Homo sapiens -0.0143621108092326 0.116754853071467 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093445 3811134 504 Q200N Transcriptional coactivator YAP1 Homo sapiens -0.191012626541315 0.0924536676137212 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094399 3811134 504 Q200N Transcriptional coactivator YAP1 Homo sapiens -0.243597745539949 0.109137162100616 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3864403 3811135 504 Q200P Transcriptional coactivator YAP1 Homo sapiens 0.696490868852961 0.164361380389577 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093446 3811135 504 Q200P Transcriptional coactivator YAP1 Homo sapiens -0.973753498551368 0.0401279532374194 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094400 3811135 504 Q200P Transcriptional coactivator YAP1 Homo sapiens -0.944207299792715 0.121200145989263 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3864404 3811136 504 Q200R Transcriptional coactivator YAP1 Homo sapiens 0.014658050049318 0.0636077590232782 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093667 3811136 504 Q200R Transcriptional coactivator YAP1 Homo sapiens -0.136195685276018 0.0417472608680284 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094601 3811136 504 Q200R Transcriptional coactivator YAP1 Homo sapiens -0.0501398242838245 0.0460752504523982 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3864405 3811137 504 Q200S Transcriptional coactivator YAP1 Homo sapiens -0.0374729139045294 0.06997826522719 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093668 3811137 504 Q200S Transcriptional coactivator YAP1 Homo sapiens -0.163250622208435 0.0481201862579427 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094602 3811137 504 Q200S Transcriptional coactivator YAP1 Homo sapiens -0.180465663509915 0.0504853395301933 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3864406 3811138 504 Q200T Transcriptional coactivator YAP1 Homo sapiens -0.0385636034053125 0.080342921259161 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093669 3811138 504 Q200T Transcriptional coactivator YAP1 Homo sapiens -0.155676661254132 0.0468125684414049 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094603 3811138 504 Q200T Transcriptional coactivator YAP1 Homo sapiens -0.197344542545684 0.0670459606964713 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3864407 3811139 504 Q200V Transcriptional coactivator YAP1 Homo sapiens -0.137177548670092 0.105523287595935 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093670 3811139 504 Q200V Transcriptional coactivator YAP1 Homo sapiens -0.0573137956856009 0.0607788465623275 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094604 3811139 504 Q200V Transcriptional coactivator YAP1 Homo sapiens -0.154827712169684 0.0560586509862806 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3864408 3811140 504 Q200W Transcriptional coactivator YAP1 Homo sapiens 0.145259415410368 0.0525823978468502 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093671 3811140 504 Q200W Transcriptional coactivator YAP1 Homo sapiens -0.162519623295955 0.0530264653079882 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094605 3811140 504 Q200W Transcriptional coactivator YAP1 Homo sapiens -0.171673990078662 0.0542803162174642 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3864409 3811141 504 Q200Y Transcriptional coactivator YAP1 Homo sapiens -0.0144241632841425 0.125281014361806 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093672 3811141 504 Q200Y Transcriptional coactivator YAP1 Homo sapiens -0.438114190471426 0.101770495320367 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094606 3811141 504 Q200Y Transcriptional coactivator YAP1 Homo sapiens 0.0363552174125738 0.0859304752268024 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093433 4905685 503 200Q Transcriptional coactivator YAP1 Homo sapiens -0.976741674165328 0.160016604698313 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094387 4905685 503 200Q Transcriptional coactivator YAP1 Homo sapiens -0.847638297301971 0.368052547063137 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3865702 3812433 504 D201A Transcriptional coactivator YAP1 Homo sapiens 0.28416306579304 0.085531729766279 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093448 3812433 504 D201A Transcriptional coactivator YAP1 Homo sapiens -0.751689445090748 0.0523576303109627 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094402 3812433 504 D201A Transcriptional coactivator YAP1 Homo sapiens -0.790452589926532 0.0855625785981717 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3865703 3812434 504 D201C Transcriptional coactivator YAP1 Homo sapiens 0.414538473116214 0.0891228670893669 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093449 3812434 504 D201C Transcriptional coactivator YAP1 Homo sapiens -0.727968892979453 0.0515488902442988 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094403 3812434 504 D201C Transcriptional coactivator YAP1 Homo sapiens -0.951140708996903 0.169005516978835 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3865704 3812435 504 D201E Transcriptional coactivator YAP1 Homo sapiens 0.404394608396119 0.109555206342967 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093650 3812435 504 D201E Transcriptional coactivator YAP1 Homo sapiens -0.905452383100692 0.0903834467848964 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094584 3812435 504 D201E Transcriptional coactivator YAP1 Homo sapiens -0.988877505465251 0.099144704123247 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3865705 3812436 504 D201F Transcriptional coactivator YAP1 Homo sapiens 0.591299748344266 0.130586026098179 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093651 3812436 504 D201F Transcriptional coactivator YAP1 Homo sapiens -0.851831509798047 0.066641892958814 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094585 3812436 504 D201F Transcriptional coactivator YAP1 Homo sapiens -0.672808730766022 0.0445034225601959 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3865706 3812437 504 D201G Transcriptional coactivator YAP1 Homo sapiens 0.587978820157081 0.0837897796013436 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093652 3812437 504 D201G Transcriptional coactivator YAP1 Homo sapiens -0.905248022492024 0.0376239701273233 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094586 3812437 504 D201G Transcriptional coactivator YAP1 Homo sapiens -0.880938718262249 0.0550244440236616 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3865707 3812438 504 D201H Transcriptional coactivator YAP1 Homo sapiens 0.0893346449034182 0.0921518524706145 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093653 3812438 504 D201H Transcriptional coactivator YAP1 Homo sapiens -0.455477590234818 0.237242288617777 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094587 3812438 504 D201H Transcriptional coactivator YAP1 Homo sapiens -0.739272860570101 0.308220053424388 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3865708 3812439 504 D201I Transcriptional coactivator YAP1 Homo sapiens 0.529254205163014 0.118783430216657 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093654 3812439 504 D201I Transcriptional coactivator YAP1 Homo sapiens -0.770138392743119 0.114329897865673 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094588 3812439 504 D201I Transcriptional coactivator YAP1 Homo sapiens -0.664027688136983 0.171461515778405 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3865709 3812440 504 D201K Transcriptional coactivator YAP1 Homo sapiens 0.234545436937882 0.108290064586539 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093655 3812440 504 D201K Transcriptional coactivator YAP1 Homo sapiens -0.701632626604842 0.0511660295638876 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094589 3812440 504 D201K Transcriptional coactivator YAP1 Homo sapiens -1.03343601684252 0.136998014183864 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3865710 3812441 504 D201L Transcriptional coactivator YAP1 Homo sapiens 0.490818658693084 0.0618811824422725 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093656 3812441 504 D201L Transcriptional coactivator YAP1 Homo sapiens -1.0189709301893 0.0902346362919987 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094590 3812441 504 D201L Transcriptional coactivator YAP1 Homo sapiens -0.875375548591475 0.0886173750504675 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3865711 3812442 504 D201M Transcriptional coactivator YAP1 Homo sapiens 0.346596493206511 0.0862755132541662 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093657 3812442 504 D201M Transcriptional coactivator YAP1 Homo sapiens -0.867887668847514 0.0761163495579364 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094591 3812442 504 D201M Transcriptional coactivator YAP1 Homo sapiens -0.847572031968169 0.113957947416757 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3865712 3812443 504 D201N Transcriptional coactivator YAP1 Homo sapiens 0.263181218250728 0.0594099919162765 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093658 3812443 504 D201N Transcriptional coactivator YAP1 Homo sapiens -0.66877219493635 0.103587332200759 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094592 3812443 504 D201N Transcriptional coactivator YAP1 Homo sapiens -0.803672984688261 0.115843355625476 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3865713 3812444 504 D201P Transcriptional coactivator YAP1 Homo sapiens 0.244710018074325 0.0967124348080203 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093659 3812444 504 D201P Transcriptional coactivator YAP1 Homo sapiens -0.580250692306009 0.078620600991046 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094593 3812444 504 D201P Transcriptional coactivator YAP1 Homo sapiens -0.43126258830941 0.105566417380851 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3865714 3812445 504 D201Q Transcriptional coactivator YAP1 Homo sapiens 0.277753759913101 0.0780253270376643 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093660 3812445 504 D201Q Transcriptional coactivator YAP1 Homo sapiens -0.755364237540359 0.0556779608077544 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094594 3812445 504 D201Q Transcriptional coactivator YAP1 Homo sapiens -0.847099953477838 0.168634005877452 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3865715 3812446 504 D201R Transcriptional coactivator YAP1 Homo sapiens 0.176553435896196 0.0780580389454989 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093661 3812446 504 D201R Transcriptional coactivator YAP1 Homo sapiens -0.794516843875645 0.0454567395061154 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094595 3812446 504 D201R Transcriptional coactivator YAP1 Homo sapiens -0.781190893293376 0.0509235270230651 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3865716 3812447 504 D201S Transcriptional coactivator YAP1 Homo sapiens 0.360059913271426 0.0789400001427306 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093662 3812447 504 D201S Transcriptional coactivator YAP1 Homo sapiens -0.821467860030127 0.0360067220571423 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094596 3812447 504 D201S Transcriptional coactivator YAP1 Homo sapiens -0.729908683003599 0.0449295547233567 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3865717 3812448 504 D201T Transcriptional coactivator YAP1 Homo sapiens 0.450122524718235 0.0683572726021599 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093663 3812448 504 D201T Transcriptional coactivator YAP1 Homo sapiens -0.738989136703483 0.0603957755746895 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094597 3812448 504 D201T Transcriptional coactivator YAP1 Homo sapiens -0.870585238241682 0.114373966143411 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3865718 3812449 504 D201V Transcriptional coactivator YAP1 Homo sapiens 0.397979541079367 0.142911832460154 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093664 3812449 504 D201V Transcriptional coactivator YAP1 Homo sapiens -0.8866653484513 0.0604205555675858 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094598 3812449 504 D201V Transcriptional coactivator YAP1 Homo sapiens -0.678157866952215 0.0682818198026934 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3865719 3812450 504 D201W Transcriptional coactivator YAP1 Homo sapiens 0.640027730335509 0.141648063546091 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093665 3812450 504 D201W Transcriptional coactivator YAP1 Homo sapiens -0.83642527259914 0.0717125307325939 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094599 3812450 504 D201W Transcriptional coactivator YAP1 Homo sapiens -1.01206895485589 0.157006388775489 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3865720 3812451 504 D201Y Transcriptional coactivator YAP1 Homo sapiens 0.390208611882018 0.10393900950193 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093666 3812451 504 D201Y Transcriptional coactivator YAP1 Homo sapiens -0.824320641301865 0.0611003628002718 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094600 3812451 504 D201Y Transcriptional coactivator YAP1 Homo sapiens -0.944012189136075 0.138642457542392 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093447 4905686 503 201D Transcriptional coactivator YAP1 Homo sapiens -1.36142795909266 0.157664282106636 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094401 4905686 503 201D Transcriptional coactivator YAP1 Homo sapiens -0.842964925776536 0.194705339587954 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3867013 3813744 504 P202A Transcriptional coactivator YAP1 Homo sapiens 0.865549429395288 0.113073137409568 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093451 3813744 504 P202A Transcriptional coactivator YAP1 Homo sapiens -0.97315789398111 0.0398659539446609 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094405 3813744 504 P202A Transcriptional coactivator YAP1 Homo sapiens -0.855806155259287 0.362479455310296 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3867014 3813745 504 P202C Transcriptional coactivator YAP1 Homo sapiens 0.97496218646365 0.100129360685518 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093452 3813745 504 P202C Transcriptional coactivator YAP1 Homo sapiens -1.01045363254318 0.0486220373168853 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094406 3813745 504 P202C Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3867015 3813746 504 P202D Transcriptional coactivator YAP1 Homo sapiens 0.937759024831088 0.125190890636368 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093453 3813746 504 P202D Transcriptional coactivator YAP1 Homo sapiens -1.00076158773602 0.122999341912427 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094407 3813746 504 P202D Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3867016 3813747 504 P202E Transcriptional coactivator YAP1 Homo sapiens 0.609015333832266 0.117102092167429 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093454 3813747 504 P202E Transcriptional coactivator YAP1 Homo sapiens -0.679107779857531 0.109114496200118 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094408 3813747 504 P202E Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3867017 3813748 504 P202F Transcriptional coactivator YAP1 Homo sapiens 1.14354404437385 0.0680127656875614 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093455 3813748 504 P202F Transcriptional coactivator YAP1 Homo sapiens -0.959312208924827 0.14714732533227 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094409 3813748 504 P202F Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3867018 3813749 504 P202G Transcriptional coactivator YAP1 Homo sapiens 0.738204976694459 0.0629609398417617 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093456 3813749 504 P202G Transcriptional coactivator YAP1 Homo sapiens -0.883283463204815 0.0448803889250706 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094410 3813749 504 P202G Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3867019 3813750 504 P202H Transcriptional coactivator YAP1 Homo sapiens 0.867491258656922 0.0888594051361053 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093457 3813750 504 P202H Transcriptional coactivator YAP1 Homo sapiens -0.974699808552255 0.228963363335279 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094411 3813750 504 P202H Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3867020 3813751 504 P202I Transcriptional coactivator YAP1 Homo sapiens 0.911741906571564 0.113378797386352 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093458 3813751 504 P202I Transcriptional coactivator YAP1 Homo sapiens -1.01482330907804 0.207105190496939 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094412 3813751 504 P202I Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3867021 3813752 504 P202K Transcriptional coactivator YAP1 Homo sapiens 0.969472246108992 0.164068042235662 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093459 3813752 504 P202K Transcriptional coactivator YAP1 Homo sapiens -0.849005705867126 0.056101069940192 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094413 3813752 504 P202K Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3867022 3813753 504 P202L Transcriptional coactivator YAP1 Homo sapiens 0.883113372065958 0.0897354361044313 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093460 3813753 504 P202L Transcriptional coactivator YAP1 Homo sapiens -1.06209899578879 0.0675404922271102 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094414 3813753 504 P202L Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3867023 3813754 504 P202M Transcriptional coactivator YAP1 Homo sapiens 0.789301426844357 0.086186481050937 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093461 3813754 504 P202M Transcriptional coactivator YAP1 Homo sapiens -0.942634918358952 0.123204862836829 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094415 3813754 504 P202M Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3867024 3813755 504 P202N Transcriptional coactivator YAP1 Homo sapiens 1.11222406366395 0.159903243600478 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093462 3813755 504 P202N Transcriptional coactivator YAP1 Homo sapiens -0.613884184332341 0.135459827541402 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094416 3813755 504 P202N Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3867025 3813756 504 P202Q Transcriptional coactivator YAP1 Homo sapiens 0.733678917966698 0.195303491864841 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093643 3813756 504 P202Q Transcriptional coactivator YAP1 Homo sapiens -0.979893019179395 0.151657980228829 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094577 3813756 504 P202Q Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3867026 3813757 504 P202R Transcriptional coactivator YAP1 Homo sapiens 0.950483248051953 0.164808780714172 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093644 3813757 504 P202R Transcriptional coactivator YAP1 Homo sapiens -0.943631266975873 0.0450174367172138 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094578 3813757 504 P202R Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3867027 3813758 504 P202S Transcriptional coactivator YAP1 Homo sapiens 0.833486358370367 0.0818786254896088 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093645 3813758 504 P202S Transcriptional coactivator YAP1 Homo sapiens -0.862977357700293 0.0682626437321173 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094579 3813758 504 P202S Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3867028 3813759 504 P202T Transcriptional coactivator YAP1 Homo sapiens 0.89465747973459 0.0985810308064319 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093646 3813759 504 P202T Transcriptional coactivator YAP1 Homo sapiens -0.925029882843936 0.0982288491012434 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094580 3813759 504 P202T Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3867029 3813760 504 P202V Transcriptional coactivator YAP1 Homo sapiens 0.800497440203752 0.0826247990735484 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093647 3813760 504 P202V Transcriptional coactivator YAP1 Homo sapiens -0.928586468128136 0.0499626081002715 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094581 3813760 504 P202V Transcriptional coactivator YAP1 Homo sapiens -0.970281893615897 0.512723803413292 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3867030 3813761 504 P202W Transcriptional coactivator YAP1 Homo sapiens 1.10055089756017 0.155801089337814 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093648 3813761 504 P202W Transcriptional coactivator YAP1 Homo sapiens -0.782832246874113 0.085055639532601 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094582 3813761 504 P202W Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3867031 3813762 504 P202Y Transcriptional coactivator YAP1 Homo sapiens 1.17624604973893 0.153911450591672 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5093649 3813762 504 P202Y Transcriptional coactivator YAP1 Homo sapiens -1.0818773751935 0.0793678443238029 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094583 3813762 504 P202Y Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093450 4905687 503 202P Transcriptional coactivator YAP1 Homo sapiens -1.34559590777526 0.197185723805898 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094404 4905687 503 202P Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093463 4905688 503 203R Transcriptional coactivator YAP1 Homo sapiens -1.43740783376435 0.118550328789242 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094417 4905688 503 203R Transcriptional coactivator YAP1 Homo sapiens -1.18466961778917 0.230287555935516 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093464 4905689 504 R203A Transcriptional coactivator YAP1 Homo sapiens -0.783065325297199 0.0721839525114099 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094418 4905689 504 R203A Transcriptional coactivator YAP1 Homo sapiens -0.869955044286416 0.0737704675499458 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093465 4905690 504 R203C Transcriptional coactivator YAP1 Homo sapiens -0.737319007243721 0.0405250640454399 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094419 4905690 504 R203C Transcriptional coactivator YAP1 Homo sapiens -0.908641950984666 0.117384821946554 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093466 4905691 504 R203D Transcriptional coactivator YAP1 Homo sapiens -0.681858163265735 0.0610032371213547 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094420 4905691 504 R203D Transcriptional coactivator YAP1 Homo sapiens -0.993390281005235 0.219549453490834 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093467 4905692 504 R203E Transcriptional coactivator YAP1 Homo sapiens -0.720042196041986 0.0927677505789939 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094421 4905692 504 R203E Transcriptional coactivator YAP1 Homo sapiens -0.796517249973764 0.118473699581361 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093468 4905693 504 R203F Transcriptional coactivator YAP1 Homo sapiens -0.796919567682022 0.107493390080121 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094422 4905693 504 R203F Transcriptional coactivator YAP1 Homo sapiens -0.908568385833343 0.125836522322993 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093469 4905694 504 R203G Transcriptional coactivator YAP1 Homo sapiens -0.812197807551512 0.0609275410236517 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094423 4905694 504 R203G Transcriptional coactivator YAP1 Homo sapiens -0.7074159608065 0.0575068922591406 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093470 4905695 504 R203H Transcriptional coactivator YAP1 Homo sapiens -0.773872071216235 0.0632161767854732 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094424 4905695 504 R203H Transcriptional coactivator YAP1 Homo sapiens -0.791056277748276 0.071844378804753 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093471 4905696 504 R203I Transcriptional coactivator YAP1 Homo sapiens -1.44831393142804 0.550253194671929 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094425 4905696 504 R203I Transcriptional coactivator YAP1 Homo sapiens -0.872979436644379 0.149030735722208 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093472 4905697 504 R203K Transcriptional coactivator YAP1 Homo sapiens -0.956971707049691 0.175662302056844 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094426 4905697 504 R203K Transcriptional coactivator YAP1 Homo sapiens -0.634581499955519 0.0719027064729024 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093473 4905698 504 R203L Transcriptional coactivator YAP1 Homo sapiens -0.894517422583118 0.0539405330354145 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094427 4905698 504 R203L Transcriptional coactivator YAP1 Homo sapiens -0.990417625218049 0.0657059055541459 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093474 4905699 504 R203M Transcriptional coactivator YAP1 Homo sapiens -0.75571559564859 0.0451628460346159 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094428 4905699 504 R203M Transcriptional coactivator YAP1 Homo sapiens -0.995487313050034 0.137326151612213 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093475 4905700 504 R203N Transcriptional coactivator YAP1 Homo sapiens -0.53472788007081 0.121237184911005 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094429 4905700 504 R203N Transcriptional coactivator YAP1 Homo sapiens -0.772397377189739 0.176410012465147 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093476 4905701 504 R203P Transcriptional coactivator YAP1 Homo sapiens -0.938498102687972 0.0932766215481278 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094430 4905701 504 R203P Transcriptional coactivator YAP1 Homo sapiens -0.494827556605611 0.0827624961669314 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093477 4905702 504 R203Q Transcriptional coactivator YAP1 Homo sapiens -0.710854598500225 0.057983544431267 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094431 4905702 504 R203Q Transcriptional coactivator YAP1 Homo sapiens -0.689871451808084 0.0329832970430229 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093638 4905863 504 R203S Transcriptional coactivator YAP1 Homo sapiens -0.670353415202988 0.0653189807305061 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094572 4905863 504 R203S Transcriptional coactivator YAP1 Homo sapiens -0.921184454925195 0.0866318955569041 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093639 4905864 504 R203T Transcriptional coactivator YAP1 Homo sapiens -0.725030901020992 0.0495169960945658 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094573 4905864 504 R203T Transcriptional coactivator YAP1 Homo sapiens -0.34576046353983 0.0746492805329972 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093640 4905865 504 R203V Transcriptional coactivator YAP1 Homo sapiens -0.886189546480588 0.0672032392070222 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094574 4905865 504 R203V Transcriptional coactivator YAP1 Homo sapiens -0.605545022891395 0.0556388831300455 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093641 4905866 504 R203W Transcriptional coactivator YAP1 Homo sapiens -0.841732701806355 0.0788592634336026 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094575 4905866 504 R203W Transcriptional coactivator YAP1 Homo sapiens -0.905918622945414 0.057979034534285 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093642 4905867 504 R203Y Transcriptional coactivator YAP1 Homo sapiens -0.865060922160059 0.0458820749943678 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094576 4905867 504 R203Y Transcriptional coactivator YAP1 Homo sapiens -0.719452155073567 0.0498368960311264 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093478 4905703 503 204K Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094432 4905703 503 204K Transcriptional coactivator YAP1 Homo sapiens -1.18985790710298 0.0871518835292144 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093479 4905704 504 K204A Transcriptional coactivator YAP1 Homo sapiens -0.493159568896872 1.12248363958441 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094433 4905704 504 K204A Transcriptional coactivator YAP1 Homo sapiens -0.256186032802014 0.0545202250746358 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093480 4905705 504 K204C Transcriptional coactivator YAP1 Homo sapiens -0.451050985709247 0.235527922120652 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094434 4905705 504 K204C Transcriptional coactivator YAP1 Homo sapiens -0.320212519658347 0.0753704032832028 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093481 4905706 504 K204D Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094435 4905706 504 K204D Transcriptional coactivator YAP1 Homo sapiens -0.0537691801597976 0.077145534636952 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093482 4905707 504 K204E Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094436 4905707 504 K204E Transcriptional coactivator YAP1 Homo sapiens -0.417414196624873 0.118192337682755 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093483 4905708 504 K204F Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094437 4905708 504 K204F Transcriptional coactivator YAP1 Homo sapiens -0.110781463715114 0.0816295361389426 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093484 4905709 504 K204G Transcriptional coactivator YAP1 Homo sapiens -0.309253876226887 0.287428699867235 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094438 4905709 504 K204G Transcriptional coactivator YAP1 Homo sapiens -0.0826452738545148 0.0388482043166479 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093485 4905710 504 K204H Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094439 4905710 504 K204H Transcriptional coactivator YAP1 Homo sapiens -0.269366101387343 0.130293379843329 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093486 4905711 504 K204I Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094440 4905711 504 K204I Transcriptional coactivator YAP1 Homo sapiens -0.670245431736102 0.121771587044291 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093627 4905852 504 K204L Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094561 4905852 504 K204L Transcriptional coactivator YAP1 Homo sapiens -0.10199900364578 0.0394563429009195 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093628 4905853 504 K204M Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094562 4905853 504 K204M Transcriptional coactivator YAP1 Homo sapiens -0.39197043460509 0.0847143823254976 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093629 4905854 504 K204N Transcriptional coactivator YAP1 Homo sapiens -0.15063871537616 0.255528937106841 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094563 4905854 504 K204N Transcriptional coactivator YAP1 Homo sapiens -0.0348661963824195 0.0839693048343024 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093630 4905855 504 K204P Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094564 4905855 504 K204P Transcriptional coactivator YAP1 Homo sapiens -0.372949803283206 0.0781619102006569 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093631 4905856 504 K204Q Transcriptional coactivator YAP1 Homo sapiens -0.493159568896872 1.12248363958441 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094565 4905856 504 K204Q Transcriptional coactivator YAP1 Homo sapiens -0.323892903384948 0.0956431304898902 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093632 4905857 504 K204R Transcriptional coactivator YAP1 Homo sapiens -0.246160982988161 0.130928649560296 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094566 4905857 504 K204R Transcriptional coactivator YAP1 Homo sapiens -0.148996362795048 0.0408658951409208 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093633 4905858 504 K204S Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094567 4905858 504 K204S Transcriptional coactivator YAP1 Homo sapiens -0.10351920836243 0.0387773110402812 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093634 4905859 504 K204T Transcriptional coactivator YAP1 Homo sapiens -0.342267759651213 0.388870028117786 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094568 4905859 504 K204T Transcriptional coactivator YAP1 Homo sapiens -0.1543011331 0.071651536052585 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093635 4905860 504 K204V Transcriptional coactivator YAP1 Homo sapiens -0.154290083951889 0.0590776786566781 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094569 4905860 504 K204V Transcriptional coactivator YAP1 Homo sapiens -0.0775431975117827 0.0558265380507329 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093636 4905861 504 K204W Transcriptional coactivator YAP1 Homo sapiens -0.342267759651213 0.281218182420227 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094570 4905861 504 K204W Transcriptional coactivator YAP1 Homo sapiens -0.32325151165135 0.0619620417639215 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093637 4905862 504 K204Y Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094571 4905862 504 K204Y Transcriptional coactivator YAP1 Homo sapiens -0.312634175119823 0.173715245847843 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q in pocket 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093487 4905712 503 205A Transcriptional coactivator YAP1 Homo sapiens -1.10679914416852 0.271342010010015 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094441 4905712 503 205A Transcriptional coactivator YAP1 Homo sapiens -0.967317742470482 0.233727825276104 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093608 4905833 504 A205C Transcriptional coactivator YAP1 Homo sapiens -0.0908701267156156 0.0502361960464243 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094542 4905833 504 A205C Transcriptional coactivator YAP1 Homo sapiens -0.302138738453686 0.06492332967994 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093609 4905834 504 A205D Transcriptional coactivator YAP1 Homo sapiens -0.0160196091038432 0.0397033139386075 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094543 4905834 504 A205D Transcriptional coactivator YAP1 Homo sapiens 0.142787974301878 0.0722701778694444 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093610 4905835 504 A205E Transcriptional coactivator YAP1 Homo sapiens -0.0711773931160296 0.0634291817463596 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094544 4905835 504 A205E Transcriptional coactivator YAP1 Homo sapiens -0.291837491107998 0.107140910060809 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093611 4905836 504 A205F Transcriptional coactivator YAP1 Homo sapiens -0.195036021349287 0.0900173671707895 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094545 4905836 504 A205F Transcriptional coactivator YAP1 Homo sapiens 0.0348945451883244 0.0777734606877452 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093612 4905837 504 A205G Transcriptional coactivator YAP1 Homo sapiens -0.0327774690935039 0.0343150832444592 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094546 4905837 504 A205G Transcriptional coactivator YAP1 Homo sapiens 0.0171623670948181 0.056550928000819 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093613 4905838 504 A205H Transcriptional coactivator YAP1 Homo sapiens -0.139344492099417 0.110806236540428 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094547 4905838 504 A205H Transcriptional coactivator YAP1 Homo sapiens -0.0378761308493708 0.0754012326096243 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093614 4905839 504 A205I Transcriptional coactivator YAP1 Homo sapiens -0.0404674616212155 0.0944399105912909 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094548 4905839 504 A205I Transcriptional coactivator YAP1 Homo sapiens -0.668971294654707 0.138426794001471 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093615 4905840 504 A205K Transcriptional coactivator YAP1 Homo sapiens -0.385142876420674 0.0856373203140493 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094549 4905840 504 A205K Transcriptional coactivator YAP1 Homo sapiens 0.0265940148193736 0.0341240104694266 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093616 4905841 504 A205L Transcriptional coactivator YAP1 Homo sapiens -0.0822090949579337 0.0605948639987401 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094550 4905841 504 A205L Transcriptional coactivator YAP1 Homo sapiens -0.156954581332698 0.0591179265499094 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093617 4905842 504 A205M Transcriptional coactivator YAP1 Homo sapiens -0.460179044549902 0.165090447844308 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094551 4905842 504 A205M Transcriptional coactivator YAP1 Homo sapiens 0.0721696813525116 0.08765245256948 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093618 4905843 504 A205N Transcriptional coactivator YAP1 Homo sapiens -0.0249903001230617 0.0388781409003595 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094552 4905843 504 A205N Transcriptional coactivator YAP1 Homo sapiens -0.423743776263286 0.134017137242966 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093619 4905844 504 A205P Transcriptional coactivator YAP1 Homo sapiens -0.0145793671988983 0.0371542235543485 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094553 4905844 504 A205P Transcriptional coactivator YAP1 Homo sapiens -0.0523049643348103 0.0716248173030197 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093620 4905845 504 A205Q Transcriptional coactivator YAP1 Homo sapiens 0.0785374208568581 0.0693068843809623 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094554 4905845 504 A205Q Transcriptional coactivator YAP1 Homo sapiens 0.00908366613207313 0.0692380250258652 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093621 4905846 504 A205R Transcriptional coactivator YAP1 Homo sapiens -0.071415257841519 0.0472526181835602 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094555 4905846 504 A205R Transcriptional coactivator YAP1 Homo sapiens -0.0606423481514373 0.036095216339217 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093622 4905847 504 A205S Transcriptional coactivator YAP1 Homo sapiens -0.072680001991682 0.0498568163132154 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094556 4905847 504 A205S Transcriptional coactivator YAP1 Homo sapiens -0.0326471936002144 0.0519909800478092 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093623 4905848 504 A205T Transcriptional coactivator YAP1 Homo sapiens -0.0835739163401624 0.0813045563234735 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094557 4905848 504 A205T Transcriptional coactivator YAP1 Homo sapiens -0.0100553214544631 0.0585272083068663 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093624 4905849 504 A205V Transcriptional coactivator YAP1 Homo sapiens -0.209792336697635 0.0538059146543396 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094558 4905849 504 A205V Transcriptional coactivator YAP1 Homo sapiens -0.0199476372749732 0.0500182149936941 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093625 4905850 504 A205W Transcriptional coactivator YAP1 Homo sapiens -0.0350038249082979 0.0598191421666846 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094559 4905850 504 A205W Transcriptional coactivator YAP1 Homo sapiens -0.201124147092953 0.0671043592366354 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093626 4905851 504 A205Y Transcriptional coactivator YAP1 Homo sapiens -0.563209280158829 0.160455929243134 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094560 4905851 504 A205Y Transcriptional coactivator YAP1 Homo sapiens -0.146953831329601 0.0791287462260431 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093488 4905713 503 206M Transcriptional coactivator YAP1 Homo sapiens -1.17896889731613 0.0663528293015577 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094442 4905713 503 206M Transcriptional coactivator YAP1 Homo sapiens -1.22227888006696 0.061784712895785 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093489 4905714 504 M206A Transcriptional coactivator YAP1 Homo sapiens -0.10641400636848 0.0585943201297477 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094443 4905714 504 M206A Transcriptional coactivator YAP1 Homo sapiens -0.0046300687244155 0.0652012542858301 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093490 4905715 504 M206C Transcriptional coactivator YAP1 Homo sapiens -0.0883478903886277 0.0492709874030177 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094444 4905715 504 M206C Transcriptional coactivator YAP1 Homo sapiens -0.0341695244773069 0.0687650748097525 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093491 4905716 504 M206D Transcriptional coactivator YAP1 Homo sapiens 0.160961899422933 0.0860620683924613 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094445 4905716 504 M206D Transcriptional coactivator YAP1 Homo sapiens -0.347537224949919 0.091487762520352 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093492 4905717 504 M206E Transcriptional coactivator YAP1 Homo sapiens -0.0246226250748206 0.0342233312777857 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094446 4905717 504 M206E Transcriptional coactivator YAP1 Homo sapiens 0.071011632631297 0.0760015185746603 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093493 4905718 504 M206F Transcriptional coactivator YAP1 Homo sapiens -0.0291645359764669 0.0921369739380468 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094447 4905718 504 M206F Transcriptional coactivator YAP1 Homo sapiens -0.00288023867993644 0.0871773974545288 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093494 4905719 504 M206G Transcriptional coactivator YAP1 Homo sapiens -0.0649341692692671 0.0489462367849647 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094448 4905719 504 M206G Transcriptional coactivator YAP1 Homo sapiens -0.0472723425665452 0.0435954386558683 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093495 4905720 504 M206H Transcriptional coactivator YAP1 Homo sapiens -0.37599016087067 0.0864797820567353 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094449 4905720 504 M206H Transcriptional coactivator YAP1 Homo sapiens 0.00280298818384557 0.0467283289812306 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093496 4905721 504 M206I Transcriptional coactivator YAP1 Homo sapiens 0.0938071759175424 0.071324506647166 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094450 4905721 504 M206I Transcriptional coactivator YAP1 Homo sapiens -0.0963937359982369 0.07811031537391 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093497 4905722 504 M206K Transcriptional coactivator YAP1 Homo sapiens -0.129890094458548 0.0668805699053172 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094451 4905722 504 M206K Transcriptional coactivator YAP1 Homo sapiens -0.193112774544232 0.101235924662836 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093498 4905723 504 M206L Transcriptional coactivator YAP1 Homo sapiens -0.0114001020874792 0.034069930285765 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094452 4905723 504 M206L Transcriptional coactivator YAP1 Homo sapiens -0.0122495190315013 0.0380942182131971 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093599 4905824 504 M206N Transcriptional coactivator YAP1 Homo sapiens -0.11607218446015 0.0817993584643314 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094533 4905824 504 M206N Transcriptional coactivator YAP1 Homo sapiens -0.289127345263491 0.153131886600453 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093600 4905825 504 M206P Transcriptional coactivator YAP1 Homo sapiens -0.0381221734436769 0.0474151856698802 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094534 4905825 504 M206P Transcriptional coactivator YAP1 Homo sapiens 0.0358052505780189 0.0446717081592488 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093601 4905826 504 M206Q Transcriptional coactivator YAP1 Homo sapiens -0.0359545586129216 0.0615876736526715 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094535 4905826 504 M206Q Transcriptional coactivator YAP1 Homo sapiens -0.276288171069168 0.113765388152648 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093602 4905827 504 M206R Transcriptional coactivator YAP1 Homo sapiens -0.0345911876253605 0.0488832388925767 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094536 4905827 504 M206R Transcriptional coactivator YAP1 Homo sapiens -0.0579300761464872 0.0461086311713512 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093603 4905828 504 M206S Transcriptional coactivator YAP1 Homo sapiens -0.104180398580348 0.0457505387019615 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094537 4905828 504 M206S Transcriptional coactivator YAP1 Homo sapiens -0.0454332137834658 0.0481444227081944 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093604 4905829 504 M206T Transcriptional coactivator YAP1 Homo sapiens -0.0192365844766203 0.0650065077033144 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094538 4905829 504 M206T Transcriptional coactivator YAP1 Homo sapiens 0.0139079241769372 0.0803254910673178 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093605 4905830 504 M206V Transcriptional coactivator YAP1 Homo sapiens -0.0476730223299428 0.0384860194499956 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094539 4905830 504 M206V Transcriptional coactivator YAP1 Homo sapiens -0.0814191879991284 0.0345656848654248 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093606 4905831 504 M206W Transcriptional coactivator YAP1 Homo sapiens -0.179972222331405 0.041271067290756 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094540 4905831 504 M206W Transcriptional coactivator YAP1 Homo sapiens -0.141225955096519 0.0386961413217741 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093607 4905832 504 M206Y Transcriptional coactivator YAP1 Homo sapiens 0.0491553256802484 0.0794204936502374 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094541 4905832 504 M206Y Transcriptional coactivator YAP1 Homo sapiens -0.0516982998884456 0.0814271965367965 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093499 4905724 503 207L Transcriptional coactivator YAP1 Homo sapiens -1.10255594204867 0.141169813788615 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094453 4905724 503 207L Transcriptional coactivator YAP1 Homo sapiens -1.03896679800255 0.169613031889377 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093500 4905725 504 L207A Transcriptional coactivator YAP1 Homo sapiens -0.1612164436871 0.0662764805262542 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094454 4905725 504 L207A Transcriptional coactivator YAP1 Homo sapiens -0.0504098466600686 0.049389502263537 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093501 4905726 504 L207C Transcriptional coactivator YAP1 Homo sapiens -0.162925733802888 0.0570100322783883 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094455 4905726 504 L207C Transcriptional coactivator YAP1 Homo sapiens -0.0827409510744437 0.0711303432560237 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093502 4905727 504 L207D Transcriptional coactivator YAP1 Homo sapiens -0.0499552183394401 0.0615750624710365 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094456 4905727 504 L207D Transcriptional coactivator YAP1 Homo sapiens 0.0829500235179922 0.0516432890305872 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093503 4905728 504 L207E Transcriptional coactivator YAP1 Homo sapiens -0.0294256070166383 0.0455409784284106 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094457 4905728 504 L207E Transcriptional coactivator YAP1 Homo sapiens 0.0130376158356571 0.0471436602493416 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093504 4905729 504 L207F Transcriptional coactivator YAP1 Homo sapiens -0.0233941407913478 0.059475848252806 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094458 4905729 504 L207F Transcriptional coactivator YAP1 Homo sapiens -0.172004253667454 0.0640696479133232 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093505 4905730 504 L207G Transcriptional coactivator YAP1 Homo sapiens 0.0090461115419346 0.0367596291810763 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094459 4905730 504 L207G Transcriptional coactivator YAP1 Homo sapiens -4.80512260087869E-4 0.0499166341349354 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093506 4905731 504 L207H Transcriptional coactivator YAP1 Homo sapiens -0.0575734163311046 0.0804895795597388 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094460 4905731 504 L207H Transcriptional coactivator YAP1 Homo sapiens 0.289607857523579 0.101529405675966 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093507 4905732 504 L207I Transcriptional coactivator YAP1 Homo sapiens -5.44623197690797E-4 0.0834045102429845 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094461 4905732 504 L207I Transcriptional coactivator YAP1 Homo sapiens 0.138071441719453 0.0622580316463744 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093508 4905733 504 L207K Transcriptional coactivator YAP1 Homo sapiens -0.00461152984569224 0.0490539575969287 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094462 4905733 504 L207K Transcriptional coactivator YAP1 Homo sapiens -0.124611428675813 0.0688623466500136 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093589 4905814 504 L207M Transcriptional coactivator YAP1 Homo sapiens -0.00423805321878048 0.0555248571466406 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094523 4905814 504 L207M Transcriptional coactivator YAP1 Homo sapiens -0.0124486693929831 0.0336615280498943 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093590 4905815 504 L207N Transcriptional coactivator YAP1 Homo sapiens -0.151769298019569 0.0843253658174553 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094524 4905815 504 L207N Transcriptional coactivator YAP1 Homo sapiens -0.519386056288999 0.198773534979335 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093591 4905816 504 L207P Transcriptional coactivator YAP1 Homo sapiens -0.01817417038259 0.0553269725501641 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094525 4905816 504 L207P Transcriptional coactivator YAP1 Homo sapiens -0.0249469491962998 0.0720343866763305 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093592 4905817 504 L207Q Transcriptional coactivator YAP1 Homo sapiens -0.0318318117702168 0.0630946409643001 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094526 4905817 504 L207Q Transcriptional coactivator YAP1 Homo sapiens 0.0270468869937042 0.073557284529541 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093593 4905818 504 L207R Transcriptional coactivator YAP1 Homo sapiens -0.0591615984921465 0.0317162515750742 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094527 4905818 504 L207R Transcriptional coactivator YAP1 Homo sapiens -0.0715793174695423 0.0433795058012908 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093594 4905819 504 L207S Transcriptional coactivator YAP1 Homo sapiens -0.0090388595685967 0.0500675006426336 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094528 4905819 504 L207S Transcriptional coactivator YAP1 Homo sapiens -0.0933185992777043 0.0543582683465012 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093595 4905820 504 L207T Transcriptional coactivator YAP1 Homo sapiens 0.0321661277411026 0.0389756436818901 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094529 4905820 504 L207T Transcriptional coactivator YAP1 Homo sapiens -0.145400316766014 0.0749152632043998 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093596 4905821 504 L207V Transcriptional coactivator YAP1 Homo sapiens -0.0171683216805968 0.0438390345616141 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094530 4905821 504 L207V Transcriptional coactivator YAP1 Homo sapiens -0.0074103778635373 0.0578652424273828 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093597 4905822 504 L207W Transcriptional coactivator YAP1 Homo sapiens -0.226830122858146 0.0500850214102184 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094531 4905822 504 L207W Transcriptional coactivator YAP1 Homo sapiens -0.184525921235642 0.0367420014331385 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093598 4905823 504 L207Y Transcriptional coactivator YAP1 Homo sapiens 0.0410875053416222 0.0683229511423968 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094532 4905823 504 L207Y Transcriptional coactivator YAP1 Homo sapiens -0.34294400967318 0.12228009375021 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093509 4905734 503 208S Transcriptional coactivator YAP1 Homo sapiens -1.3346813513301 0.0761200480643388 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094463 4905734 503 208S Transcriptional coactivator YAP1 Homo sapiens -1.17454394168566 0.192141048349828 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093510 4905735 504 S208A Transcriptional coactivator YAP1 Homo sapiens -0.0148360870550667 0.0484412673774867 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094464 4905735 504 S208A Transcriptional coactivator YAP1 Homo sapiens -0.00219419757703814 0.0531560592728882 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093511 4905736 504 S208C Transcriptional coactivator YAP1 Homo sapiens -0.0577307841525413 0.0556947491260321 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094465 4905736 504 S208C Transcriptional coactivator YAP1 Homo sapiens -0.139096251052914 0.064059286424765 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093512 4905737 504 S208D Transcriptional coactivator YAP1 Homo sapiens -0.0516616076658929 0.0401725891333154 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094466 4905737 504 S208D Transcriptional coactivator YAP1 Homo sapiens -0.270648884854539 0.113396924547899 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093513 4905738 504 S208E Transcriptional coactivator YAP1 Homo sapiens 0.067456405596255 0.0558995956169131 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094467 4905738 504 S208E Transcriptional coactivator YAP1 Homo sapiens 0.0349611648822008 0.0710560693845529 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093514 4905739 504 S208F Transcriptional coactivator YAP1 Homo sapiens -0.195228198642747 0.0737548169601204 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094468 4905739 504 S208F Transcriptional coactivator YAP1 Homo sapiens -0.350394075864984 0.0538282661585049 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093515 4905740 504 S208G Transcriptional coactivator YAP1 Homo sapiens -0.00563623367836438 0.0364040359204163 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094469 4905740 504 S208G Transcriptional coactivator YAP1 Homo sapiens -0.0421100250112655 0.0343561659281832 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093516 4905741 504 S208H Transcriptional coactivator YAP1 Homo sapiens 0.0950458129636883 0.0907555455368738 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094470 4905741 504 S208H Transcriptional coactivator YAP1 Homo sapiens -0.111268354456531 0.0522128590644253 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093517 4905742 504 S208I Transcriptional coactivator YAP1 Homo sapiens -0.0731890905200159 0.0928260564446322 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094471 4905742 504 S208I Transcriptional coactivator YAP1 Homo sapiens -0.651132879411072 0.210727305093233 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093518 4905743 504 S208K Transcriptional coactivator YAP1 Homo sapiens -0.0385232075692734 0.035319249488638 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094472 4905743 504 S208K Transcriptional coactivator YAP1 Homo sapiens 0.0105896964457702 0.0331240276027362 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093519 4905744 504 S208L Transcriptional coactivator YAP1 Homo sapiens -0.0442928775570586 0.0446482387545716 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094473 4905744 504 S208L Transcriptional coactivator YAP1 Homo sapiens -0.124804200555966 0.0429219560739859 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093520 4905745 504 S208M Transcriptional coactivator YAP1 Homo sapiens -0.0208008351256466 0.0572577886955108 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094474 4905745 504 S208M Transcriptional coactivator YAP1 Homo sapiens -0.244752959380573 0.061614967333228 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093521 4905746 504 S208N Transcriptional coactivator YAP1 Homo sapiens -0.278997193065704 0.0889748234837056 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094475 4905746 504 S208N Transcriptional coactivator YAP1 Homo sapiens -0.276653870665341 0.159108523605351 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093522 4905747 504 S208P Transcriptional coactivator YAP1 Homo sapiens -0.00509161048067378 0.0464017514037754 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094476 4905747 504 S208P Transcriptional coactivator YAP1 Homo sapiens 0.0296280457713442 0.0560415283075141 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093523 4905748 504 S208Q Transcriptional coactivator YAP1 Homo sapiens 0.0322756325385079 0.0707003583098499 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094477 4905748 504 S208Q Transcriptional coactivator YAP1 Homo sapiens -0.142347859090205 0.0784708413130054 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093524 4905749 504 S208R Transcriptional coactivator YAP1 Homo sapiens -0.0993237520358285 0.0477262155543776 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094478 4905749 504 S208R Transcriptional coactivator YAP1 Homo sapiens -0.0575523283078047 0.0468518092925508 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093585 4905810 504 S208T Transcriptional coactivator YAP1 Homo sapiens -0.134188339056035 0.0687635230266326 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094519 4905810 504 S208T Transcriptional coactivator YAP1 Homo sapiens 0.112982748493629 0.0661174168206612 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093586 4905811 504 S208V Transcriptional coactivator YAP1 Homo sapiens -0.131422436424887 0.0350320060766895 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094520 4905811 504 S208V Transcriptional coactivator YAP1 Homo sapiens -0.20177191730788 0.0598288579043921 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093587 4905812 504 S208W Transcriptional coactivator YAP1 Homo sapiens -0.319857711641844 0.0523688926255568 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094521 4905812 504 S208W Transcriptional coactivator YAP1 Homo sapiens -0.256897587830226 0.0391768874595106 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093588 4905813 504 S208Y Transcriptional coactivator YAP1 Homo sapiens -0.590462195963375 0.102598380596643 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094522 4905813 504 S208Y Transcriptional coactivator YAP1 Homo sapiens -0.59930396239942 0.14333595672002 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093525 4905750 503 209Q Transcriptional coactivator YAP1 Homo sapiens -1.43460530866784 0.210202435789904 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094479 4905750 503 209Q Transcriptional coactivator YAP1 Homo sapiens -1.30572672279104 0.537750908858288 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093526 4905751 504 Q209A Transcriptional coactivator YAP1 Homo sapiens -0.0826514653315573 0.0333655171075429 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094480 4905751 504 Q209A Transcriptional coactivator YAP1 Homo sapiens -0.128274803118872 0.0382713840756997 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093527 4905752 504 Q209C Transcriptional coactivator YAP1 Homo sapiens -0.0756090740229371 0.0396799988443255 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094481 4905752 504 Q209C Transcriptional coactivator YAP1 Homo sapiens -0.196625191595848 0.0341019480112312 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093528 4905753 504 Q209D Transcriptional coactivator YAP1 Homo sapiens -0.0167332032803113 0.061230245642757 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094482 4905753 504 Q209D Transcriptional coactivator YAP1 Homo sapiens -0.143760338344416 0.0931645235176113 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093529 4905754 504 Q209E Transcriptional coactivator YAP1 Homo sapiens -0.0800791903885363 0.0696908981251343 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094483 4905754 504 Q209E Transcriptional coactivator YAP1 Homo sapiens 0.10466662628143 0.0791193202480797 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093530 4905755 504 Q209F Transcriptional coactivator YAP1 Homo sapiens -0.415758532262093 0.0795128837905647 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094484 4905755 504 Q209F Transcriptional coactivator YAP1 Homo sapiens -0.186936987177853 0.0867616622159337 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093531 4905756 504 Q209G Transcriptional coactivator YAP1 Homo sapiens -0.059684465769823 0.0386448449180731 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094485 4905756 504 Q209G Transcriptional coactivator YAP1 Homo sapiens -0.104438418393896 0.066302414040795 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093532 4905757 504 Q209H Transcriptional coactivator YAP1 Homo sapiens -0.216378578883289 0.0728871183502178 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094486 4905757 504 Q209H Transcriptional coactivator YAP1 Homo sapiens 0.110155663824764 0.0946194551086648 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093533 4905758 504 Q209I Transcriptional coactivator YAP1 Homo sapiens -0.305706936067227 0.0752432844877636 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094487 4905758 504 Q209I Transcriptional coactivator YAP1 Homo sapiens -0.175315394197145 0.100769657677715 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093534 4905759 504 Q209K Transcriptional coactivator YAP1 Homo sapiens 0.0630479310040293 0.0680846440465338 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094488 4905759 504 Q209K Transcriptional coactivator YAP1 Homo sapiens 0.154087099615418 0.074369194330657 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093535 4905760 504 Q209L Transcriptional coactivator YAP1 Homo sapiens -0.343311318614564 0.0592285342060571 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094489 4905760 504 Q209L Transcriptional coactivator YAP1 Homo sapiens -0.278835311279722 0.0361632747349932 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093536 4905761 504 Q209M Transcriptional coactivator YAP1 Homo sapiens -0.077143591581277 0.0689239149209511 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094490 4905761 504 Q209M Transcriptional coactivator YAP1 Homo sapiens -0.139526444182521 0.0792901218036566 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093537 4905762 504 Q209N Transcriptional coactivator YAP1 Homo sapiens -0.267789993469018 0.099352252291047 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094491 4905762 504 Q209N Transcriptional coactivator YAP1 Homo sapiens -0.0217236899649142 0.102786037369715 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093538 4905763 504 Q209P Transcriptional coactivator YAP1 Homo sapiens -0.0330073566483214 0.0643107606332313 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094492 4905763 504 Q209P Transcriptional coactivator YAP1 Homo sapiens -0.298303145014755 0.0793197463058272 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093579 4905804 504 Q209R Transcriptional coactivator YAP1 Homo sapiens -0.128204010657442 0.0355962241063397 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094513 4905804 504 Q209R Transcriptional coactivator YAP1 Homo sapiens -0.153188442468233 0.0357670222132561 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093580 4905805 504 Q209S Transcriptional coactivator YAP1 Homo sapiens -0.0116524707596448 0.0426676160563389 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094514 4905805 504 Q209S Transcriptional coactivator YAP1 Homo sapiens -0.0159632126050413 0.0617501982245958 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093581 4905806 504 Q209T Transcriptional coactivator YAP1 Homo sapiens 3.03132485532065E-4 0.0599761328855075 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094515 4905806 504 Q209T Transcriptional coactivator YAP1 Homo sapiens -0.314356365078545 0.0967441272392212 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093582 4905807 504 Q209V Transcriptional coactivator YAP1 Homo sapiens -0.241054143363478 0.0442500256466037 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094516 4905807 504 Q209V Transcriptional coactivator YAP1 Homo sapiens -0.242425522415782 0.0690990591793194 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093583 4905808 504 Q209W Transcriptional coactivator YAP1 Homo sapiens -0.282938640574956 0.0444692818085076 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094517 4905808 504 Q209W Transcriptional coactivator YAP1 Homo sapiens -0.321640590755805 0.080085518425333 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093584 4905809 504 Q209Y Transcriptional coactivator YAP1 Homo sapiens -0.184766501905217 0.0797909969680805 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094518 4905809 504 Q209Y Transcriptional coactivator YAP1 Homo sapiens -0.41774871253455 0.11391081752694 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093539 4905764 503 210M Transcriptional coactivator YAP1 Homo sapiens -1.08102693628014 0.163487616697123 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094493 4905764 503 210M Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093540 4905765 504 M210A Transcriptional coactivator YAP1 Homo sapiens -0.0568590969573026 0.0629559977380225 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094494 4905765 504 M210A Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093541 4905766 504 M210C Transcriptional coactivator YAP1 Homo sapiens -0.0141217676812647 0.0392029422822259 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094495 4905766 504 M210C Transcriptional coactivator YAP1 Homo sapiens -0.825466412715701 0.340231454180171 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093542 4905767 504 M210D Transcriptional coactivator YAP1 Homo sapiens 0.0289875878270172 0.0753156591816778 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094496 4905767 504 M210D Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093543 4905768 504 M210E Transcriptional coactivator YAP1 Homo sapiens 0.103311612174444 0.0730357112839153 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094497 4905768 504 M210E Transcriptional coactivator YAP1 Homo sapiens -0.0153104813490814 0.127783589184555 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093544 4905769 504 M210F Transcriptional coactivator YAP1 Homo sapiens 0.0180088253904814 0.0762395605849506 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094498 4905769 504 M210F Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093545 4905770 504 M210G Transcriptional coactivator YAP1 Homo sapiens 0.0557125599725503 0.0352589348263851 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094499 4905770 504 M210G Transcriptional coactivator YAP1 Homo sapiens -0.12440660855315 0.103474062889026 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093546 4905771 504 M210H Transcriptional coactivator YAP1 Homo sapiens -0.377167881340776 0.131018356470488 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094500 4905771 504 M210H Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093547 4905772 504 M210I Transcriptional coactivator YAP1 Homo sapiens -0.0440296309248858 0.0812747507130539 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094501 4905772 504 M210I Transcriptional coactivator YAP1 Homo sapiens -0.485737653736239 0.256540109387766 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093548 4905773 504 M210K Transcriptional coactivator YAP1 Homo sapiens 0.0407140287147105 0.0385371096021624 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094502 4905773 504 M210K Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093549 4905774 504 M210L Transcriptional coactivator YAP1 Homo sapiens -0.0571361223388178 0.0525381101714278 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094503 4905774 504 M210L Transcriptional coactivator YAP1 Homo sapiens -0.0175549980566008 0.0411137558381487 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093570 4905795 504 M210N Transcriptional coactivator YAP1 Homo sapiens 0.0762189649806703 0.0570294240550943 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094504 4905795 504 M210N Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093571 4905796 504 M210P Transcriptional coactivator YAP1 Homo sapiens -0.0128120612964055 0.0743819676143985 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094505 4905796 504 M210P Transcriptional coactivator YAP1 Homo sapiens -0.538735533759379 0.385622782602912 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093572 4905797 504 M210Q Transcriptional coactivator YAP1 Homo sapiens -0.127609348843719 0.0746804588369944 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094506 4905797 504 M210Q Transcriptional coactivator YAP1 Homo sapiens 0.351421011358888 0.0984184077159638 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093573 4905798 504 M210R Transcriptional coactivator YAP1 Homo sapiens -0.110647708403258 0.0452305069458603 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094507 4905798 504 M210R Transcriptional coactivator YAP1 Homo sapiens -0.0932859981509137 0.0729714564555166 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093574 4905799 504 M210S Transcriptional coactivator YAP1 Homo sapiens 0.0439360804688244 0.0579691710201109 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094508 4905799 504 M210S Transcriptional coactivator YAP1 Homo sapiens 0.453999039365276 0.121264639522697 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093575 4905800 504 M210T Transcriptional coactivator YAP1 Homo sapiens 0.102378283205832 0.0546550337085499 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094509 4905800 504 M210T Transcriptional coactivator YAP1 Homo sapiens 0.0672143100803374 0.126512145239721 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093576 4905801 504 M210V Transcriptional coactivator YAP1 Homo sapiens -0.0318484913088943 0.0432328058504164 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094510 4905801 504 M210V Transcriptional coactivator YAP1 Homo sapiens -0.105836014525007 0.0699053559168662 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093577 4905802 504 M210W Transcriptional coactivator YAP1 Homo sapiens -0.148985265455076 0.0372566866856424 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094511 4905802 504 M210W Transcriptional coactivator YAP1 Homo sapiens -0.183427405006828 0.0871494738807125 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093578 4905803 504 M210Y Transcriptional coactivator YAP1 Homo sapiens -0.162246949098443 0.0923865143406105 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094512 4905803 504 M210Y Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093550 4905775 503 211N Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093551 4905776 504 N211A Transcriptional coactivator YAP1 Homo sapiens -0.162561684741316 0.0337847536862179 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093552 4905777 504 N211C Transcriptional coactivator YAP1 Homo sapiens -0.200551872270239 0.0844225422601857 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093553 4905778 504 N211D Transcriptional coactivator YAP1 Homo sapiens 0.0989582525795884 0.0744109755077509 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093554 4905779 504 N211E Transcriptional coactivator YAP1 Homo sapiens -0.148207853913232 0.199660532227255 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093555 4905780 504 N211F Transcriptional coactivator YAP1 Homo sapiens -0.134758344160409 0.102746610931674 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093556 4905781 504 N211G Transcriptional coactivator YAP1 Homo sapiens -0.320838903634488 0.106640050377428 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093557 4905782 504 N211H Transcriptional coactivator YAP1 Homo sapiens -0.323746219745728 0.107987104424979 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093558 4905783 504 N211I Transcriptional coactivator YAP1 Homo sapiens -0.182844728970623 0.0907112359797781 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093559 4905784 504 N211K Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093560 4905785 504 N211L Transcriptional coactivator YAP1 Homo sapiens -0.313791435944531 0.0954818016007745 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093561 4905786 504 N211M Transcriptional coactivator YAP1 Homo sapiens -0.662674083076083 0.13617255148107 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093562 4905787 504 N211P Transcriptional coactivator YAP1 Homo sapiens 0.0955164660333305 0.116119612365781 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093563 4905788 504 N211Q Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093564 4905789 504 N211R Transcriptional coactivator YAP1 Homo sapiens -0.233470754843836 0.033794065219984 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093565 4905790 504 N211S Transcriptional coactivator YAP1 Homo sapiens -0.0394536357485504 0.0345600766597399 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093566 4905791 504 N211T Transcriptional coactivator YAP1 Homo sapiens -0.57735135336544 0.149701615381412 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093567 4905792 504 N211V Transcriptional coactivator YAP1 Homo sapiens -0.241021509483456 0.0393737552622313 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093568 4905793 504 N211W Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5093569 4905794 504 N211Y Transcriptional coactivator YAP1 Homo sapiens -0.259475606036897 0.0710600344314992 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094933 4905975 503 226N Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094934 4905976 504 N226A Transcriptional coactivator YAP1 Homo sapiens -0.589587431560646 0.140294109302843 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094935 4905977 504 N226C Transcriptional coactivator YAP1 Homo sapiens -0.723792839777117 0.1311146291493 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094936 4905978 504 N226D Transcriptional coactivator YAP1 Homo sapiens -0.196911844323464 0.1362644953522 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094937 4905979 504 N226E Transcriptional coactivator YAP1 Homo sapiens -0.184409163991248 0.082154855455055 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094938 4905980 504 N226F Transcriptional coactivator YAP1 Homo sapiens -0.442526931816188 0.111982337523251 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094939 4905981 504 N226G Transcriptional coactivator YAP1 Homo sapiens -0.174666733011317 0.0727152084722484 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094940 4905982 504 N226H Transcriptional coactivator YAP1 Homo sapiens -1.12479906484757 0.238002719215608 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094941 4905983 504 N226I Transcriptional coactivator YAP1 Homo sapiens -0.371861843050957 0.12859547393185 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094942 4905984 504 N226K Transcriptional coactivator YAP1 Homo sapiens -0.0995973397736818 0.0701043579145394 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094943 4905985 504 N226L Transcriptional coactivator YAP1 Homo sapiens -0.91434099247626 0.250054641041607 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094944 4905986 504 N226M Transcriptional coactivator YAP1 Homo sapiens -0.122871278532501 0.0775181935263655 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095865 4906335 504 N226P Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095866 4906336 504 N226Q Transcriptional coactivator YAP1 Homo sapiens -1.09244916523205 0.366885914728832 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095867 4906337 504 N226R Transcriptional coactivator YAP1 Homo sapiens -0.286518497770454 0.0725748487185029 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095868 4906338 504 N226S Transcriptional coactivator YAP1 Homo sapiens -0.407528656892464 0.0758342663696244 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095869 4906339 504 N226T Transcriptional coactivator YAP1 Homo sapiens -0.0569642581088084 0.0848599634755117 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095870 4906340 504 N226V Transcriptional coactivator YAP1 Homo sapiens -0.0745617428811177 0.0687555436483167 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095871 4906341 504 N226W Transcriptional coactivator YAP1 Homo sapiens -0.70079174319267 0.128652684058235 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095872 4906342 504 N226Y Transcriptional coactivator YAP1 Homo sapiens -0.546829983515328 0.136031437688527 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094945 4905987 503 227S Transcriptional coactivator YAP1 Homo sapiens -1.28789429787028 0.118075414905799 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094946 4905988 504 S227A Transcriptional coactivator YAP1 Homo sapiens -0.13740137752993 0.0509009395402628 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094947 4905989 504 S227C Transcriptional coactivator YAP1 Homo sapiens 0.0484089969281305 0.077437041081442 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094948 4905990 504 S227D Transcriptional coactivator YAP1 Homo sapiens 0.0340181437181474 0.0622329924727746 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094949 4905991 504 S227E Transcriptional coactivator YAP1 Homo sapiens 0.0200911779029125 0.0568525272889617 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094950 4905992 504 S227F Transcriptional coactivator YAP1 Homo sapiens -0.00861971208800981 0.074708802346465 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094951 4905993 504 S227G Transcriptional coactivator YAP1 Homo sapiens -0.127410691203238 0.048655302833867 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094952 4905994 504 S227H Transcriptional coactivator YAP1 Homo sapiens 0.0362230013010769 0.0693696096140511 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094953 4905995 504 S227I Transcriptional coactivator YAP1 Homo sapiens 0.0190647375268826 0.105982674171824 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094954 4905996 504 S227K Transcriptional coactivator YAP1 Homo sapiens 0.153915927921017 0.0766118068898203 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094955 4905997 504 S227L Transcriptional coactivator YAP1 Homo sapiens -0.136191928404686 0.05524393608168 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094956 4905998 504 S227M Transcriptional coactivator YAP1 Homo sapiens -0.0461834513996374 0.0683547942720474 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094957 4905999 504 S227N Transcriptional coactivator YAP1 Homo sapiens 0.239031705800323 0.0740212146049591 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094958 4906000 504 S227P Transcriptional coactivator YAP1 Homo sapiens -0.378047538774412 0.0776139548436176 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094959 4906001 504 S227Q Transcriptional coactivator YAP1 Homo sapiens 0.0270638112479906 0.0718216642757568 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094960 4906002 504 S227R Transcriptional coactivator YAP1 Homo sapiens -0.171744958545594 0.0524199121587444 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095861 4906331 504 S227T Transcriptional coactivator YAP1 Homo sapiens -0.028248593976602 0.0635132659839653 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095862 4906332 504 S227V Transcriptional coactivator YAP1 Homo sapiens -0.142771490784059 0.0512206399113366 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095863 4906333 504 S227W Transcriptional coactivator YAP1 Homo sapiens -0.609846022684579 0.0618101865637737 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095864 4906334 504 S227Y Transcriptional coactivator YAP1 Homo sapiens -0.138912393246272 0.0708394404049175 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094961 4906003 503 228A Transcriptional coactivator YAP1 Homo sapiens -1.21206328587363 0.10306997057454 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095842 4906312 504 A228C Transcriptional coactivator YAP1 Homo sapiens -0.0273613993880179 0.065587709940824 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095843 4906313 504 A228D Transcriptional coactivator YAP1 Homo sapiens -0.00596767660482551 0.0720247880735808 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095844 4906314 504 A228E Transcriptional coactivator YAP1 Homo sapiens -0.0168312350962497 0.0578449916928549 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095845 4906315 504 A228F Transcriptional coactivator YAP1 Homo sapiens 0.0364235152349991 0.077450933832578 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095846 4906316 504 A228G Transcriptional coactivator YAP1 Homo sapiens -0.0181027480581847 0.048130640620575 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095847 4906317 504 A228H Transcriptional coactivator YAP1 Homo sapiens -0.125695183101905 0.0726152618244708 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095848 4906318 504 A228I Transcriptional coactivator YAP1 Homo sapiens 0.112563907500647 0.0815710575450602 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095849 4906319 504 A228K Transcriptional coactivator YAP1 Homo sapiens 0.15073714551618 0.0563047264042473 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095850 4906320 504 A228L Transcriptional coactivator YAP1 Homo sapiens -0.090387225546901 0.0500157023496052 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095851 4906321 504 A228M Transcriptional coactivator YAP1 Homo sapiens -0.00605440683814904 0.0586778008553137 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095852 4906322 504 A228N Transcriptional coactivator YAP1 Homo sapiens 0.167749002291003 0.0734205321486238 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095853 4906323 504 A228P Transcriptional coactivator YAP1 Homo sapiens -0.180331251644617 0.0547365880874441 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095854 4906324 504 A228Q Transcriptional coactivator YAP1 Homo sapiens 0.0526150153992115 0.0581512687700188 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095855 4906325 504 A228R Transcriptional coactivator YAP1 Homo sapiens -0.0688351604111272 0.0469782663543789 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095856 4906326 504 A228S Transcriptional coactivator YAP1 Homo sapiens 0.0165479693800743 0.0504558224776621 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095857 4906327 504 A228T Transcriptional coactivator YAP1 Homo sapiens 0.0730276521485708 0.0521592917860585 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095858 4906328 504 A228V Transcriptional coactivator YAP1 Homo sapiens 0.105285729113401 0.0487221328549389 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095859 4906329 504 A228W Transcriptional coactivator YAP1 Homo sapiens -0.255249463741596 0.0609083831028611 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095860 4906330 504 A228Y Transcriptional coactivator YAP1 Homo sapiens 0.0701806725629619 0.0752069839894358 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094962 4906004 503 229S Transcriptional coactivator YAP1 Homo sapiens -1.21227761298967 0.0836120029439106 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094963 4906005 504 S229A Transcriptional coactivator YAP1 Homo sapiens -0.265171720709886 0.0482160102236326 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094964 4906006 504 S229C Transcriptional coactivator YAP1 Homo sapiens -0.0811715414886225 0.0569532775838555 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094965 4906007 504 S229D Transcriptional coactivator YAP1 Homo sapiens -0.0467587354243428 0.0579342203934503 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094966 4906008 504 S229E Transcriptional coactivator YAP1 Homo sapiens -0.0237099769960788 0.051641377025781 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094967 4906009 504 S229F Transcriptional coactivator YAP1 Homo sapiens -0.131061317904964 0.0815998615308062 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094968 4906010 504 S229G Transcriptional coactivator YAP1 Homo sapiens -0.0133166714211146 0.043043920393056 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094969 4906011 504 S229H Transcriptional coactivator YAP1 Homo sapiens -0.253892016236552 0.0956989351393241 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094970 4906012 504 S229I Transcriptional coactivator YAP1 Homo sapiens -0.105292094635113 0.0653630945503205 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094971 4906013 504 S229K Transcriptional coactivator YAP1 Homo sapiens 0.0568472916473537 0.0739317949387124 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094972 4906014 504 S229L Transcriptional coactivator YAP1 Homo sapiens -0.0951884202980367 0.0471989032938126 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094973 4906015 504 S229M Transcriptional coactivator YAP1 Homo sapiens -0.131815632227814 0.0582330179826028 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094974 4906016 504 S229N Transcriptional coactivator YAP1 Homo sapiens -0.0891960772965778 0.0757774700021507 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094975 4906017 504 S229P Transcriptional coactivator YAP1 Homo sapiens -0.358249174870243 0.0572563559863592 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094976 4906018 504 S229Q Transcriptional coactivator YAP1 Homo sapiens -0.0392434413533325 0.0591437172601077 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094977 4906019 504 S229R Transcriptional coactivator YAP1 Homo sapiens -0.0527630137790112 0.0469090810902737 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095838 4906308 504 S229T Transcriptional coactivator YAP1 Homo sapiens -0.0147425482845608 0.0561668014625566 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095839 4906309 504 S229V Transcriptional coactivator YAP1 Homo sapiens -0.105902389029233 0.0442057076744834 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095840 4906310 504 S229W Transcriptional coactivator YAP1 Homo sapiens -0.198029789074101 0.0515581637432034 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095841 4906311 504 S229Y Transcriptional coactivator YAP1 Homo sapiens -0.0979375299873263 0.0792085816876441 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094978 4906020 503 230G Transcriptional coactivator YAP1 Homo sapiens -0.9193690385074 0.0658009469612676 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094979 4906021 504 G230A Transcriptional coactivator YAP1 Homo sapiens -0.0431478932333164 0.0525858692666736 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094980 4906022 504 G230C Transcriptional coactivator YAP1 Homo sapiens -0.112630745478621 0.0542718572610689 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094981 4906023 504 G230D Transcriptional coactivator YAP1 Homo sapiens -0.125423852738939 0.0491216091268659 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094982 4906024 504 G230E Transcriptional coactivator YAP1 Homo sapiens 0.016313240766951 0.0556449878202307 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094983 4906025 504 G230F Transcriptional coactivator YAP1 Homo sapiens -0.00129697504878205 0.0582000047956249 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095824 4906294 504 G230H Transcriptional coactivator YAP1 Homo sapiens -0.210011292316163 0.0677780859618592 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095825 4906295 504 G230I Transcriptional coactivator YAP1 Homo sapiens -0.0350294659801117 0.0609198489988445 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095826 4906296 504 G230K Transcriptional coactivator YAP1 Homo sapiens -0.098386299268009 0.0620523707942018 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095827 4906297 504 G230L Transcriptional coactivator YAP1 Homo sapiens -0.0914256012761407 0.0451613634490781 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095828 4906298 504 G230M Transcriptional coactivator YAP1 Homo sapiens -0.0647278075265793 0.0534362552259591 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095829 4906299 504 G230N Transcriptional coactivator YAP1 Homo sapiens -0.0322835390516779 0.0676772322272376 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095830 4906300 504 G230P Transcriptional coactivator YAP1 Homo sapiens -0.373965647976711 0.0514765816255643 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095831 4906301 504 G230Q Transcriptional coactivator YAP1 Homo sapiens -0.300501161900667 0.0584174351034962 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095832 4906302 504 G230R Transcriptional coactivator YAP1 Homo sapiens -0.14459043861321 0.0433988539268046 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095833 4906303 504 G230S Transcriptional coactivator YAP1 Homo sapiens -0.0891730022803725 0.0444863237422466 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095834 4906304 504 G230T Transcriptional coactivator YAP1 Homo sapiens -0.0573652859766527 0.0528748639523899 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095835 4906305 504 G230V Transcriptional coactivator YAP1 Homo sapiens 0.00464921792026613 0.0464908424431011 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095836 4906306 504 G230W Transcriptional coactivator YAP1 Homo sapiens -0.228107674852636 0.047315750401735 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095837 4906307 504 G230Y Transcriptional coactivator YAP1 Homo sapiens -0.142430139682263 0.0696626543629566 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094984 4906026 503 231P Transcriptional coactivator YAP1 Homo sapiens -0.931519387212868 0.0752388991239184 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094985 4906027 504 P231A Transcriptional coactivator YAP1 Homo sapiens 0.020624290346277 0.0500254336409221 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094986 4906028 504 P231C Transcriptional coactivator YAP1 Homo sapiens -0.0271043914489035 0.0675923082106999 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094987 4906029 504 P231D Transcriptional coactivator YAP1 Homo sapiens -0.0699546965421924 0.0722421467693328 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094988 4906030 504 P231E Transcriptional coactivator YAP1 Homo sapiens 0.0845198059090366 0.0551182886399909 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094989 4906031 504 P231F Transcriptional coactivator YAP1 Homo sapiens -0.152294311264933 0.0761120975216386 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094990 4906032 504 P231G Transcriptional coactivator YAP1 Homo sapiens -0.0413154186705278 0.0502079888467148 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094991 4906033 504 P231H Transcriptional coactivator YAP1 Homo sapiens -0.151443718426192 0.0727597193828183 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094992 4906034 504 P231I Transcriptional coactivator YAP1 Homo sapiens -0.105700283714883 0.0742836968927458 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094993 4906035 504 P231K Transcriptional coactivator YAP1 Homo sapiens 0.034743813193294 0.0532606782233429 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094994 4906036 504 P231L Transcriptional coactivator YAP1 Homo sapiens -0.0256490740475399 0.0469168151991535 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094995 4906037 504 P231M Transcriptional coactivator YAP1 Homo sapiens -0.0476491127737828 0.0609369802091514 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094996 4906038 504 P231N Transcriptional coactivator YAP1 Homo sapiens 0.0229755549285783 0.0729649835873179 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095817 4906287 504 P231Q Transcriptional coactivator YAP1 Homo sapiens -0.0522593418735638 0.0547507434163508 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095818 4906288 504 P231R Transcriptional coactivator YAP1 Homo sapiens 0.0610063643958102 0.052063848744892 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095819 4906289 504 P231S Transcriptional coactivator YAP1 Homo sapiens 0.042136570971352 0.0524708045048304 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095820 4906290 504 P231T Transcriptional coactivator YAP1 Homo sapiens -0.0795523119031799 0.0555609470198304 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095821 4906291 504 P231V Transcriptional coactivator YAP1 Homo sapiens -0.0285493648774853 0.0473347435271427 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095822 4906292 504 P231W Transcriptional coactivator YAP1 Homo sapiens -0.408929071669063 0.0663302480485071 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095823 4906293 504 P231Y Transcriptional coactivator YAP1 Homo sapiens -0.205838692834069 0.0655114589476186 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3829149 3775937 504 L232A Transcriptional coactivator YAP1 Homo sapiens 0.517897715533365 0.0676826207296087 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5094998 3775937 504 L232A Transcriptional coactivator YAP1 Homo sapiens -0.451354876033195 0.0459715033973406 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3829150 3775938 504 L232C Transcriptional coactivator YAP1 Homo sapiens 0.152278083255584 0.0722324048741152 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5094999 3775938 504 L232C Transcriptional coactivator YAP1 Homo sapiens -0.104262471498227 0.0584575856316935 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3829151 3775939 504 L232D Transcriptional coactivator YAP1 Homo sapiens 0.697723096151041 0.0925604531191808 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095000 3775939 504 L232D Transcriptional coactivator YAP1 Homo sapiens -0.250451451751317 0.0560924044275498 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3829152 3775940 504 L232E Transcriptional coactivator YAP1 Homo sapiens 0.547614250119055 0.0346656684467263 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095001 3775940 504 L232E Transcriptional coactivator YAP1 Homo sapiens -0.348865600176815 0.0485854571468841 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3829153 3775941 504 L232F Transcriptional coactivator YAP1 Homo sapiens -0.0496444746750835 0.133520938018987 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095002 3775941 504 L232F Transcriptional coactivator YAP1 Homo sapiens 0.0769599531860438 0.0559816125221556 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3829154 3775942 504 L232G Transcriptional coactivator YAP1 Homo sapiens 0.673237394802775 0.0717065837426067 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095003 3775942 504 L232G Transcriptional coactivator YAP1 Homo sapiens -0.276410049292094 0.0447864501340565 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3829155 3775943 504 L232H Transcriptional coactivator YAP1 Homo sapiens 0.502862706038798 0.0670349474600961 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095004 3775943 504 L232H Transcriptional coactivator YAP1 Homo sapiens -0.29206207149123 0.0762302336477078 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3829156 3775944 504 L232I Transcriptional coactivator YAP1 Homo sapiens 0.157296958634056 0.0595687555094161 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095005 3775944 504 L232I Transcriptional coactivator YAP1 Homo sapiens -0.126267284365754 0.0608941402480309 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3829157 3775945 504 L232K Transcriptional coactivator YAP1 Homo sapiens 0.492886958244417 0.100884784076213 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095006 3775945 504 L232K Transcriptional coactivator YAP1 Homo sapiens -0.325074462778911 0.053666018732147 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3829158 3775946 504 L232M Transcriptional coactivator YAP1 Homo sapiens -0.093206116637493 0.111875336946998 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095807 3775946 504 L232M Transcriptional coactivator YAP1 Homo sapiens 0.0708665575274099 0.0535930459826232 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3829159 3775947 504 L232N Transcriptional coactivator YAP1 Homo sapiens 0.519018360004446 0.110449309318167 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095808 3775947 504 L232N Transcriptional coactivator YAP1 Homo sapiens -0.238168381918158 0.0832121686113872 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3829160 3775948 504 L232P Transcriptional coactivator YAP1 Homo sapiens 0.50042148848759 0.0581755005535739 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095809 3775948 504 L232P Transcriptional coactivator YAP1 Homo sapiens -0.662543073744852 0.0695551884426569 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3829161 3775949 504 L232Q Transcriptional coactivator YAP1 Homo sapiens 0.387227630972329 0.158272295617738 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095810 3775949 504 L232Q Transcriptional coactivator YAP1 Homo sapiens -0.221250416588585 0.061496461826207 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3829162 3775950 504 L232R Transcriptional coactivator YAP1 Homo sapiens 0.715949896628008 0.0610729822648774 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095811 3775950 504 L232R Transcriptional coactivator YAP1 Homo sapiens -0.415596159971974 0.045778190459855 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3829163 3775951 504 L232S Transcriptional coactivator YAP1 Homo sapiens 0.606874870034307 0.0578847584220655 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095812 3775951 504 L232S Transcriptional coactivator YAP1 Homo sapiens -0.279907107782521 0.0482880997570189 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3829164 3775952 504 L232T Transcriptional coactivator YAP1 Homo sapiens 0.406784141808117 0.0782480200738001 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095813 3775952 504 L232T Transcriptional coactivator YAP1 Homo sapiens -0.215185665777654 0.0583001424090539 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3829165 3775953 504 L232V Transcriptional coactivator YAP1 Homo sapiens 0.196634057436938 0.0682644830869163 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095814 3775953 504 L232V Transcriptional coactivator YAP1 Homo sapiens -0.161798830870885 0.0451296790647575 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3829166 3775954 504 L232W Transcriptional coactivator YAP1 Homo sapiens 0.505438732209153 0.0546911276058396 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095815 3775954 504 L232W Transcriptional coactivator YAP1 Homo sapiens -0.364745985467363 0.0544863355582463 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3829167 3775955 504 L232Y Transcriptional coactivator YAP1 Homo sapiens 0.327002893121249 0.0993461653689409 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095816 3775955 504 L232Y Transcriptional coactivator YAP1 Homo sapiens 0.0737811707812066 0.0655636721394598 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5094997 4906039 503 232L Transcriptional coactivator YAP1 Homo sapiens -1.1730221248865 0.0741288237494973 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3830156 3776940 504 P233A Transcriptional coactivator YAP1 Homo sapiens 0.288315092493105 0.0713578817818298 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095008 3776940 504 P233A Transcriptional coactivator YAP1 Homo sapiens -0.218564962116413 0.0484318173234674 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3830157 3776941 504 P233C Transcriptional coactivator YAP1 Homo sapiens 0.419030177026425 0.0671175273042086 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095009 3776941 504 P233C Transcriptional coactivator YAP1 Homo sapiens -0.0326042022079107 0.0529529848175981 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3830158 3776942 504 P233D Transcriptional coactivator YAP1 Homo sapiens 0.328589932653912 0.103720299959215 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095010 3776942 504 P233D Transcriptional coactivator YAP1 Homo sapiens -0.348247348880555 0.0752515744690271 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3830159 3776943 504 P233E Transcriptional coactivator YAP1 Homo sapiens 0.318137493480208 0.0734507630884647 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095011 3776943 504 P233E Transcriptional coactivator YAP1 Homo sapiens -0.167965430029205 0.0550288451030378 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3830160 3776944 504 P233F Transcriptional coactivator YAP1 Homo sapiens 0.532118010600985 0.0751104001007963 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095012 3776944 504 P233F Transcriptional coactivator YAP1 Homo sapiens -0.331457489675432 0.0855081327238171 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3830161 3776945 504 P233G Transcriptional coactivator YAP1 Homo sapiens 0.276883141544592 0.0817836900642089 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095013 3776945 504 P233G Transcriptional coactivator YAP1 Homo sapiens -0.176130803005034 0.0447822409328246 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3830162 3776946 504 P233H Transcriptional coactivator YAP1 Homo sapiens 0.527153463771197 0.12267712624312 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095014 3776946 504 P233H Transcriptional coactivator YAP1 Homo sapiens -0.175621561268089 0.0715154667676143 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3830163 3776947 504 P233I Transcriptional coactivator YAP1 Homo sapiens 0.556988794232708 0.170459523670466 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095015 3776947 504 P233I Transcriptional coactivator YAP1 Homo sapiens -0.299584526774166 0.0801760534619162 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3830164 3776948 504 P233K Transcriptional coactivator YAP1 Homo sapiens 0.322278121087519 0.145767828450572 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095016 3776948 504 P233K Transcriptional coactivator YAP1 Homo sapiens -0.102017033714385 0.056915904014505 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3830165 3776949 504 P233L Transcriptional coactivator YAP1 Homo sapiens 0.404711453662338 0.0854279406329038 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095017 3776949 504 P233L Transcriptional coactivator YAP1 Homo sapiens -0.190242368949911 0.0480952801474659 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3830166 3776950 504 P233M Transcriptional coactivator YAP1 Homo sapiens 0.244138285493224 0.0832025474048827 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095018 3776950 504 P233M Transcriptional coactivator YAP1 Homo sapiens -0.169123159290541 0.0575312669552882 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3830167 3776951 504 P233N Transcriptional coactivator YAP1 Homo sapiens 0.450955018579092 0.0494421897284038 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095019 3776951 504 P233N Transcriptional coactivator YAP1 Homo sapiens -0.0855740954425558 0.0899494367911711 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3830168 3776952 504 P233Q Transcriptional coactivator YAP1 Homo sapiens 0.351231569121442 0.0853651837323212 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095800 3776952 504 P233Q Transcriptional coactivator YAP1 Homo sapiens -0.251466752464351 0.0533105123014443 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3830169 3776953 504 P233R Transcriptional coactivator YAP1 Homo sapiens 0.487495761264801 0.0996200811792298 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095801 3776953 504 P233R Transcriptional coactivator YAP1 Homo sapiens -0.184254800089736 0.0430042791065957 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3830170 3776954 504 P233S Transcriptional coactivator YAP1 Homo sapiens 0.426879256963338 0.0662915949546891 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095802 3776954 504 P233S Transcriptional coactivator YAP1 Homo sapiens -0.119960643729774 0.0475310482598329 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3830171 3776955 504 P233T Transcriptional coactivator YAP1 Homo sapiens 0.436271456730033 0.0712107063285897 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095803 3776955 504 P233T Transcriptional coactivator YAP1 Homo sapiens -0.0243027662054912 0.0523257103943117 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3830172 3776956 504 P233V Transcriptional coactivator YAP1 Homo sapiens 0.610105730760086 0.113562053837625 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095804 3776956 504 P233V Transcriptional coactivator YAP1 Homo sapiens -0.147060261037394 0.0515445892681529 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3830173 3776957 504 P233W Transcriptional coactivator YAP1 Homo sapiens 0.664672546364471 0.100007402771135 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095805 3776957 504 P233W Transcriptional coactivator YAP1 Homo sapiens -0.326562403479047 0.0493522240215828 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3830174 3776958 504 P233Y Transcriptional coactivator YAP1 Homo sapiens 0.480086508513861 0.112578002680765 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095806 3776958 504 P233Y Transcriptional coactivator YAP1 Homo sapiens -0.238399132080211 0.069739072451107 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095007 4906040 503 233P Transcriptional coactivator YAP1 Homo sapiens -1.28611858784736 0.0782557426564069 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3831200 3777982 504 D234A Transcriptional coactivator YAP1 Homo sapiens -0.0851349569423858 0.0972884772139236 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095021 3777982 504 D234A Transcriptional coactivator YAP1 Homo sapiens -0.12005373948481 0.0518643453375416 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3831201 3777983 504 D234C Transcriptional coactivator YAP1 Homo sapiens 0.073757189381356 0.0891793561768556 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095022 3777983 504 D234C Transcriptional coactivator YAP1 Homo sapiens -0.148115346261127 0.0549430299134604 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3831202 3777984 504 D234E Transcriptional coactivator YAP1 Homo sapiens -0.193464186921157 0.063465577565462 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095783 3777984 504 D234E Transcriptional coactivator YAP1 Homo sapiens -0.0667600003330758 0.0567831192315965 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3831203 3777985 504 D234F Transcriptional coactivator YAP1 Homo sapiens 0.00766470439405678 0.0828119444946688 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095784 3777985 504 D234F Transcriptional coactivator YAP1 Homo sapiens -0.120616292466091 0.0681701066164812 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3831204 3777986 504 D234G Transcriptional coactivator YAP1 Homo sapiens -0.018334276029677 0.0814105942699941 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095785 3777986 504 D234G Transcriptional coactivator YAP1 Homo sapiens -0.0746309679297336 0.0456656400790879 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3831205 3777987 504 D234H Transcriptional coactivator YAP1 Homo sapiens -0.140921773670836 0.100942420949942 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095786 3777987 504 D234H Transcriptional coactivator YAP1 Homo sapiens -0.118051782906444 0.0749872541368461 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3831206 3777988 504 D234I Transcriptional coactivator YAP1 Homo sapiens 0.00783106869519325 0.0767220045095531 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095787 3777988 504 D234I Transcriptional coactivator YAP1 Homo sapiens -0.309786866697776 0.0819774165373382 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3831207 3777989 504 D234K Transcriptional coactivator YAP1 Homo sapiens -0.113343834917263 0.0899581291405671 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095788 3777989 504 D234K Transcriptional coactivator YAP1 Homo sapiens -0.209221171933684 0.0595188851959978 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3831208 3777990 504 D234L Transcriptional coactivator YAP1 Homo sapiens -0.0239656236490795 0.0827743376161056 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095789 3777990 504 D234L Transcriptional coactivator YAP1 Homo sapiens -0.111287620397428 0.0473613116233873 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3831209 3777991 504 D234M Transcriptional coactivator YAP1 Homo sapiens 0.0267210488087164 0.0910882709801422 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095790 3777991 504 D234M Transcriptional coactivator YAP1 Homo sapiens -0.171725861980459 0.0629555985405975 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3831210 3777992 504 D234N Transcriptional coactivator YAP1 Homo sapiens -0.120170046016798 0.106190155902387 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095791 3777992 504 D234N Transcriptional coactivator YAP1 Homo sapiens -0.0403056877889915 0.0493961620351986 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3831211 3777993 504 D234P Transcriptional coactivator YAP1 Homo sapiens -0.167901085636316 0.0964776292512126 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095792 3777993 504 D234P Transcriptional coactivator YAP1 Homo sapiens -0.214168773684192 0.0604200202771307 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3831212 3777994 504 D234Q Transcriptional coactivator YAP1 Homo sapiens -0.132859970684144 0.106734060293576 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095793 3777994 504 D234Q Transcriptional coactivator YAP1 Homo sapiens -0.191187648924116 0.0616404897118389 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3831213 3777995 504 D234R Transcriptional coactivator YAP1 Homo sapiens -0.0913938971985074 0.0687343305094633 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095794 3777995 504 D234R Transcriptional coactivator YAP1 Homo sapiens -0.20909227011902 0.0438012105973062 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3831214 3777996 504 D234S Transcriptional coactivator YAP1 Homo sapiens -0.109478552226638 0.0856756374045774 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095795 3777996 504 D234S Transcriptional coactivator YAP1 Homo sapiens -0.100826681154276 0.0467791687490377 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3831215 3777997 504 D234T Transcriptional coactivator YAP1 Homo sapiens -0.087619593446597 0.0819805083976014 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095796 3777997 504 D234T Transcriptional coactivator YAP1 Homo sapiens -0.0747622568150398 0.0585295398977434 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3831216 3777998 504 D234V Transcriptional coactivator YAP1 Homo sapiens -0.0766325446996855 0.0567247325048722 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095797 3777998 504 D234V Transcriptional coactivator YAP1 Homo sapiens -0.196366000836676 0.0501296213175402 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3831217 3777999 504 D234W Transcriptional coactivator YAP1 Homo sapiens 0.100626926020475 0.0923781745367732 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095798 3777999 504 D234W Transcriptional coactivator YAP1 Homo sapiens -0.30665025587428 0.0487985191154807 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3831218 3778000 504 D234Y Transcriptional coactivator YAP1 Homo sapiens 0.0478233959017194 0.0732374323871478 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095799 3778000 504 D234Y Transcriptional coactivator YAP1 Homo sapiens -0.194502494355543 0.0582978110367269 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095020 4906041 503 234D Transcriptional coactivator YAP1 Homo sapiens -1.26632382841986 0.0930043302296919 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3832397 3779177 504 G235A Transcriptional coactivator YAP1 Homo sapiens 0.250238026672603 0.0470429136367351 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095024 3779177 504 G235A Transcriptional coactivator YAP1 Homo sapiens -0.315936756361602 0.0480491380719574 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3832398 3779178 504 G235C Transcriptional coactivator YAP1 Homo sapiens 0.282198730918861 0.0951311004481369 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095025 3779178 504 G235C Transcriptional coactivator YAP1 Homo sapiens -0.188561075527778 0.0521184330935708 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3832399 3779179 504 G235D Transcriptional coactivator YAP1 Homo sapiens 0.117654616208222 0.0741478800634587 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095026 3779179 504 G235D Transcriptional coactivator YAP1 Homo sapiens -0.0223636691540301 0.0464473579729073 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3832400 3779180 504 G235E Transcriptional coactivator YAP1 Homo sapiens 0.196974859927712 0.0955934557522677 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095027 3779180 504 G235E Transcriptional coactivator YAP1 Homo sapiens -0.13085443844933 0.0500714165783878 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3832401 3779181 504 G235F Transcriptional coactivator YAP1 Homo sapiens 0.145114006647712 0.123694588107084 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095028 3779181 504 G235F Transcriptional coactivator YAP1 Homo sapiens -0.0905996748340328 0.070072681487121 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3832402 3779182 504 G235H Transcriptional coactivator YAP1 Homo sapiens 0.0426093777327088 0.11027377679312 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095769 3779182 504 G235H Transcriptional coactivator YAP1 Homo sapiens -0.232375757160407 0.0715902139063153 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3832403 3779183 504 G235I Transcriptional coactivator YAP1 Homo sapiens 0.644689295356406 0.0654038014279663 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095770 3779183 504 G235I Transcriptional coactivator YAP1 Homo sapiens -0.492253512169642 0.0604500734965126 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3832404 3779184 504 G235K Transcriptional coactivator YAP1 Homo sapiens 0.303171362412837 0.149907870911956 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095771 3779184 504 G235K Transcriptional coactivator YAP1 Homo sapiens -0.29364072087576 0.0556510111951505 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3832405 3779185 504 G235L Transcriptional coactivator YAP1 Homo sapiens 0.380318025325507 0.0931555802845226 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095772 3779185 504 G235L Transcriptional coactivator YAP1 Homo sapiens -0.290190608107957 0.0462442819164961 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3832406 3779186 504 G235M Transcriptional coactivator YAP1 Homo sapiens 0.284927390153498 0.0620174392975861 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095773 3779186 504 G235M Transcriptional coactivator YAP1 Homo sapiens -0.136845985760575 0.0546995327941792 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3832407 3779187 504 G235N Transcriptional coactivator YAP1 Homo sapiens -0.0703468396438444 0.103460945280243 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095774 3779187 504 G235N Transcriptional coactivator YAP1 Homo sapiens -0.0200991348050523 0.0698749524689478 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3832408 3779188 504 G235P Transcriptional coactivator YAP1 Homo sapiens 0.333205012332097 0.0992362141988508 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095775 3779188 504 G235P Transcriptional coactivator YAP1 Homo sapiens -0.308248797514159 0.0530065268120966 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3832409 3779189 504 G235Q Transcriptional coactivator YAP1 Homo sapiens 0.168877750451138 0.0594137593558166 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095776 3779189 504 G235Q Transcriptional coactivator YAP1 Homo sapiens -0.164725379477891 0.0550530659131512 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3832410 3779190 504 G235R Transcriptional coactivator YAP1 Homo sapiens 0.294948272953839 0.0538236735264546 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095777 3779190 504 G235R Transcriptional coactivator YAP1 Homo sapiens -0.288404283577579 0.0449639765776968 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3832411 3779191 504 G235S Transcriptional coactivator YAP1 Homo sapiens 0.209073787209618 0.0788672282445654 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095778 3779191 504 G235S Transcriptional coactivator YAP1 Homo sapiens -0.152065152483308 0.0451217142057156 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3832412 3779192 504 G235T Transcriptional coactivator YAP1 Homo sapiens 0.369949171996796 0.136136967915641 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095779 3779192 504 G235T Transcriptional coactivator YAP1 Homo sapiens -0.190439700122978 0.0500910382990645 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3832413 3779193 504 G235V Transcriptional coactivator YAP1 Homo sapiens 0.66548061038291 0.0986586582905038 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095780 3779193 504 G235V Transcriptional coactivator YAP1 Homo sapiens -0.451692248683921 0.0455010356445226 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3832414 3779194 504 G235W Transcriptional coactivator YAP1 Homo sapiens 0.37698602437695 0.0893589734705797 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095781 3779194 504 G235W Transcriptional coactivator YAP1 Homo sapiens -0.247074542483199 0.0499899538142809 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3832415 3779195 504 G235Y Transcriptional coactivator YAP1 Homo sapiens 0.262761015958894 0.0839245544620711 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095782 3779195 504 G235Y Transcriptional coactivator YAP1 Homo sapiens -0.151887713565591 0.0620342131435189 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095023 4906042 503 235G Transcriptional coactivator YAP1 Homo sapiens -1.24042575107676 0.0783786051823471 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3833651 3780430 504 W236A Transcriptional coactivator YAP1 Homo sapiens 0.49650018932734 0.0682775914809433 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095030 3780430 504 W236A Transcriptional coactivator YAP1 Homo sapiens -0.784567976596746 0.0523733881519332 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3833652 3780431 504 W236C Transcriptional coactivator YAP1 Homo sapiens 0.431261684871836 0.0702337995784325 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095031 3780431 504 W236C Transcriptional coactivator YAP1 Homo sapiens -0.417914005565288 0.0523027308609321 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3833653 3780432 504 W236D Transcriptional coactivator YAP1 Homo sapiens 0.593718842878342 0.0704098216005525 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095032 3780432 504 W236D Transcriptional coactivator YAP1 Homo sapiens -0.683125510785873 0.0629539832894632 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3833654 3780433 504 W236E Transcriptional coactivator YAP1 Homo sapiens 0.442973245550612 0.0876159655418547 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095033 3780433 504 W236E Transcriptional coactivator YAP1 Homo sapiens -0.689593756104312 0.0801000650464815 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3833655 3780434 504 W236F Transcriptional coactivator YAP1 Homo sapiens 0.197412537827687 0.0709026832624884 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095034 3780434 504 W236F Transcriptional coactivator YAP1 Homo sapiens -0.399317929574438 0.0477885813544886 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3833656 3780435 504 W236G Transcriptional coactivator YAP1 Homo sapiens 0.594304360147127 0.0638215623424586 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095035 3780435 504 W236G Transcriptional coactivator YAP1 Homo sapiens -0.74799264366892 0.0634517591304248 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3833657 3780436 504 W236H Transcriptional coactivator YAP1 Homo sapiens 0.536168424460408 0.0608877126865626 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095036 3780436 504 W236H Transcriptional coactivator YAP1 Homo sapiens -0.583076935091845 0.0486541252123503 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3833658 3780437 504 W236I Transcriptional coactivator YAP1 Homo sapiens 0.334047228617573 0.0903478475802079 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095037 3780437 504 W236I Transcriptional coactivator YAP1 Homo sapiens -0.35054132376745 0.0483952235305266 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3833659 3780438 504 W236K Transcriptional coactivator YAP1 Homo sapiens 0.497979156908561 0.0841740741883609 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095038 3780438 504 W236K Transcriptional coactivator YAP1 Homo sapiens -1.01970103905565 0.0942487897243516 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3833660 3780439 504 W236L Transcriptional coactivator YAP1 Homo sapiens 0.54160893123711 0.0673632998460096 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095039 3780439 504 W236L Transcriptional coactivator YAP1 Homo sapiens -0.774856100121031 0.046172144641697 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3833661 3780440 504 W236M Transcriptional coactivator YAP1 Homo sapiens 0.491692157779999 0.062367533230499 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095040 3780440 504 W236M Transcriptional coactivator YAP1 Homo sapiens -0.500798986360688 0.0628213894722061 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3833662 3780441 504 W236N Transcriptional coactivator YAP1 Homo sapiens 0.416526821478979 0.0839218425357594 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095041 3780441 504 W236N Transcriptional coactivator YAP1 Homo sapiens -0.807351690614734 0.0518673450896483 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3833663 3780442 504 W236P Transcriptional coactivator YAP1 Homo sapiens 0.615939646896887 0.0644939782824035 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095042 3780442 504 W236P Transcriptional coactivator YAP1 Homo sapiens -0.983112099825162 0.057735632029846 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3833664 3780443 504 W236Q Transcriptional coactivator YAP1 Homo sapiens 0.479923995485671 0.0570106269274383 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095043 3780443 504 W236Q Transcriptional coactivator YAP1 Homo sapiens -0.761150256616261 0.0745662385308268 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3833665 3780444 504 W236R Transcriptional coactivator YAP1 Homo sapiens 0.661374236317893 0.0625463977114835 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095044 3780444 504 W236R Transcriptional coactivator YAP1 Homo sapiens -0.847377375017427 0.0522401259548964 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3833666 3780445 504 W236S Transcriptional coactivator YAP1 Homo sapiens 0.50157766932088 0.0558214472397538 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095045 3780445 504 W236S Transcriptional coactivator YAP1 Homo sapiens -0.860513345190948 0.0461251352638552 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3833667 3780446 504 W236T Transcriptional coactivator YAP1 Homo sapiens 0.473152878125647 0.0694139820038415 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095046 3780446 504 W236T Transcriptional coactivator YAP1 Homo sapiens -0.655728225769205 0.0471670359007428 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3833668 3780447 504 W236V Transcriptional coactivator YAP1 Homo sapiens 0.265803763522213 0.0574385317651653 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095047 3780447 504 W236V Transcriptional coactivator YAP1 Homo sapiens -0.289680570680798 0.0481200101993163 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3833669 3780448 504 W236Y Transcriptional coactivator YAP1 Homo sapiens 0.0796049284653816 0.13002585014912 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095768 3780448 504 W236Y Transcriptional coactivator YAP1 Homo sapiens -0.187225907348725 0.0472964628709482 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095029 4906043 503 236W Transcriptional coactivator YAP1 Homo sapiens -1.09968891178196 0.0685206399833465 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3834960 3781738 504 E237A Transcriptional coactivator YAP1 Homo sapiens 0.135305514939364 0.0410704360698965 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095049 3781738 504 E237A Transcriptional coactivator YAP1 Homo sapiens -0.22564342225995 0.0448453869082057 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3834961 3781739 504 E237C Transcriptional coactivator YAP1 Homo sapiens 0.194936380313002 0.078556234437608 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095050 3781739 504 E237C Transcriptional coactivator YAP1 Homo sapiens -0.103110312068389 0.0641581012902741 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3834962 3781740 504 E237D Transcriptional coactivator YAP1 Homo sapiens 0.194921785423266 0.0634066207375577 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095051 3781740 504 E237D Transcriptional coactivator YAP1 Homo sapiens -0.250296292159591 0.0599140090424543 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3834963 3781741 504 E237F Transcriptional coactivator YAP1 Homo sapiens 0.441735999500934 0.0814595315991932 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095752 3781741 504 E237F Transcriptional coactivator YAP1 Homo sapiens -0.39713932976857 0.0658211256650941 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3834964 3781742 504 E237G Transcriptional coactivator YAP1 Homo sapiens 0.267839688749899 0.0553486763381371 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095753 3781742 504 E237G Transcriptional coactivator YAP1 Homo sapiens -0.207259795556232 0.0434933262259101 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3834965 3781743 504 E237H Transcriptional coactivator YAP1 Homo sapiens 0.276849360620161 0.146261218994403 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095754 3781743 504 E237H Transcriptional coactivator YAP1 Homo sapiens -0.184028028378753 0.0652357841160842 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3834966 3781744 504 E237I Transcriptional coactivator YAP1 Homo sapiens 0.276835947275084 0.0659139631542658 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095755 3781744 504 E237I Transcriptional coactivator YAP1 Homo sapiens -0.60939009219197 0.0667824149264036 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3834967 3781745 504 E237K Transcriptional coactivator YAP1 Homo sapiens 0.275781570580143 0.117369150517575 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095756 3781745 504 E237K Transcriptional coactivator YAP1 Homo sapiens -0.076470603704448 0.0547254165968399 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3834968 3781746 504 E237L Transcriptional coactivator YAP1 Homo sapiens 0.343814619451011 0.10652622096172 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095757 3781746 504 E237L Transcriptional coactivator YAP1 Homo sapiens -0.338004428756033 0.0497426612526791 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3834969 3781747 504 E237M Transcriptional coactivator YAP1 Homo sapiens 0.236002067698651 0.0740270586825092 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095758 3781747 504 E237M Transcriptional coactivator YAP1 Homo sapiens -0.22939510161885 0.0596562451976366 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3834970 3781748 504 E237N Transcriptional coactivator YAP1 Homo sapiens 0.314120117860002 0.0789136978333489 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095759 3781748 504 E237N Transcriptional coactivator YAP1 Homo sapiens -0.20716351704034 0.0632709464862008 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3834971 3781749 504 E237P Transcriptional coactivator YAP1 Homo sapiens 1.06963049274821 0.0972634509727733 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095760 3781749 504 E237P Transcriptional coactivator YAP1 Homo sapiens -1.27350834611202 0.0945510724366413 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3834972 3781750 504 E237Q Transcriptional coactivator YAP1 Homo sapiens -0.00913243886141613 0.0570530331278768 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095761 3781750 504 E237Q Transcriptional coactivator YAP1 Homo sapiens -0.0853990435954808 0.058903999669343 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3834973 3781751 504 E237R Transcriptional coactivator YAP1 Homo sapiens 0.33827765361894 0.0583250987360045 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095762 3781751 504 E237R Transcriptional coactivator YAP1 Homo sapiens -0.228290683601851 0.0449127182141125 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3834974 3781752 504 E237S Transcriptional coactivator YAP1 Homo sapiens 0.0738249582818524 0.0618596400699441 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095763 3781752 504 E237S Transcriptional coactivator YAP1 Homo sapiens -0.134949060290454 0.0474180045511332 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3834975 3781753 504 E237T Transcriptional coactivator YAP1 Homo sapiens 0.106266956305198 0.0749712760304444 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095764 3781753 504 E237T Transcriptional coactivator YAP1 Homo sapiens -0.256479600812405 0.0565666198812756 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3834976 3781754 504 E237V Transcriptional coactivator YAP1 Homo sapiens 0.139204719214498 0.0982927451625328 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095765 3781754 504 E237V Transcriptional coactivator YAP1 Homo sapiens -0.178735892765594 0.0449735885154817 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3834977 3781755 504 E237W Transcriptional coactivator YAP1 Homo sapiens 0.72752268769983 0.0349523989527985 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095766 3781755 504 E237W Transcriptional coactivator YAP1 Homo sapiens -0.55239893975393 0.0533288211332679 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3834978 3781756 504 E237Y Transcriptional coactivator YAP1 Homo sapiens 0.441528452742041 0.142787770270998 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095767 3781756 504 E237Y Transcriptional coactivator YAP1 Homo sapiens -0.292529937337048 0.0589117496920271 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095048 4906044 503 237E Transcriptional coactivator YAP1 Homo sapiens -1.09503038428619 0.0620332185307514 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3836271 3783048 504 Q238A Transcriptional coactivator YAP1 Homo sapiens -0.0806499765839229 0.069905163621801 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095053 3783048 504 Q238A Transcriptional coactivator YAP1 Homo sapiens -0.0864040003357336 0.0470749586291814 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3836272 3783049 504 Q238C Transcriptional coactivator YAP1 Homo sapiens 0.047648413638899 0.0989253554255688 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095054 3783049 504 Q238C Transcriptional coactivator YAP1 Homo sapiens -0.145737823901765 0.0524977386185735 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3836273 3783050 504 Q238D Transcriptional coactivator YAP1 Homo sapiens 0.322671260380267 0.0554615543631387 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095055 3783050 504 Q238D Transcriptional coactivator YAP1 Homo sapiens -0.220221589141913 0.0613792487007861 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3836274 3783051 504 Q238E Transcriptional coactivator YAP1 Homo sapiens -0.251414361281928 0.118560152034595 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095056 3783051 504 Q238E Transcriptional coactivator YAP1 Homo sapiens 0.0388440048659161 0.0607146404926599 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3836275 3783052 504 Q238F Transcriptional coactivator YAP1 Homo sapiens 0.229034161262531 0.0931107423526486 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095057 3783052 504 Q238F Transcriptional coactivator YAP1 Homo sapiens -0.39479443070798 0.062721641746982 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3836276 3783053 504 Q238G Transcriptional coactivator YAP1 Homo sapiens 0.260909456709179 0.0581561322234174 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095058 3783053 504 Q238G Transcriptional coactivator YAP1 Homo sapiens -0.25867172735191 0.0440233275205378 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3836277 3783054 504 Q238H Transcriptional coactivator YAP1 Homo sapiens 0.272482844179734 0.0605398771918686 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095059 3783054 504 Q238H Transcriptional coactivator YAP1 Homo sapiens -0.312461977197166 0.0703462238688819 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3836278 3783055 504 Q238I Transcriptional coactivator YAP1 Homo sapiens -0.117877568058902 0.124394529536453 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095060 3783055 504 Q238I Transcriptional coactivator YAP1 Homo sapiens -0.225129406381721 0.0763117282394232 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3836279 3783056 504 Q238K Transcriptional coactivator YAP1 Homo sapiens -0.0234776108213665 0.0822305457529797 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095061 3783056 504 Q238K Transcriptional coactivator YAP1 Homo sapiens -0.0919069938555966 0.0594305476684421 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3836280 3783057 504 Q238L Transcriptional coactivator YAP1 Homo sapiens -0.0266470165962486 0.107398515998363 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095062 3783057 504 Q238L Transcriptional coactivator YAP1 Homo sapiens -0.102197655392958 0.0475192561308617 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3836281 3783058 504 Q238M Transcriptional coactivator YAP1 Homo sapiens -0.0473389895984168 0.0832172930822223 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095063 3783058 504 Q238M Transcriptional coactivator YAP1 Homo sapiens -0.145971756824674 0.0570788852410338 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3836282 3783059 504 Q238N Transcriptional coactivator YAP1 Homo sapiens 0.38821815924448 0.18381293630126 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095064 3783059 504 Q238N Transcriptional coactivator YAP1 Homo sapiens -0.2320622552161 0.0628622799923023 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3836283 3783060 504 Q238P Transcriptional coactivator YAP1 Homo sapiens 0.257529473794675 0.0689874848921792 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095065 3783060 504 Q238P Transcriptional coactivator YAP1 Homo sapiens -0.13084648154719 0.059619380870023 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3836284 3783061 504 Q238R Transcriptional coactivator YAP1 Homo sapiens 0.0273989786237348 0.0922874150277811 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095746 3783061 504 Q238R Transcriptional coactivator YAP1 Homo sapiens -0.0802509279110515 0.0436467114284584 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3836285 3783062 504 Q238S Transcriptional coactivator YAP1 Homo sapiens -0.00873109177177319 0.0674341700199148 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095747 3783062 504 Q238S Transcriptional coactivator YAP1 Homo sapiens -0.0721261351361351 0.0468349148054289 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3836286 3783063 504 Q238T Transcriptional coactivator YAP1 Homo sapiens 0.069093940940641 0.0868311475706135 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095748 3783063 504 Q238T Transcriptional coactivator YAP1 Homo sapiens 0.0147767629637619 0.0557273894987901 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3836287 3783064 504 Q238V Transcriptional coactivator YAP1 Homo sapiens -0.0721170748626268 0.101322259425675 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095749 3783064 504 Q238V Transcriptional coactivator YAP1 Homo sapiens -0.101234074543832 0.0449118588686814 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3836288 3783065 504 Q238W Transcriptional coactivator YAP1 Homo sapiens 0.301468610273271 0.0588022368517356 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095750 3783065 504 Q238W Transcriptional coactivator YAP1 Homo sapiens -0.294539850817554 0.0514265884094202 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3836289 3783066 504 Q238Y Transcriptional coactivator YAP1 Homo sapiens 0.169176658744158 0.0942402720395624 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095751 3783066 504 Q238Y Transcriptional coactivator YAP1 Homo sapiens -0.210161677766605 0.0594174903920307 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095052 4906045 503 238Q Transcriptional coactivator YAP1 Homo sapiens -1.33516364361874 0.133588987007704 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3837582 3784358 504 A239C Transcriptional coactivator YAP1 Homo sapiens 0.019350608111891 0.0731706075970976 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095727 3784358 504 A239C Transcriptional coactivator YAP1 Homo sapiens -0.0721134040927113 0.0519164869172635 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3837583 3784359 504 A239D Transcriptional coactivator YAP1 Homo sapiens 0.136402945996385 0.0798002051643147 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095728 3784359 504 A239D Transcriptional coactivator YAP1 Homo sapiens -0.117710431804648 0.0588777100646732 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3837584 3784360 504 A239E Transcriptional coactivator YAP1 Homo sapiens 0.188035022973178 0.04800191267099 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095729 3784360 504 A239E Transcriptional coactivator YAP1 Homo sapiens -0.103521683909015 0.0686667764480455 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3837585 3784361 504 A239F Transcriptional coactivator YAP1 Homo sapiens 0.169317003743991 0.0543544098837431 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095730 3784361 504 A239F Transcriptional coactivator YAP1 Homo sapiens -0.430054805988188 0.0627978131711659 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3837586 3784362 504 A239G Transcriptional coactivator YAP1 Homo sapiens 0.105001263161263 0.0841626525899942 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095731 3784362 504 A239G Transcriptional coactivator YAP1 Homo sapiens -0.0469990338689636 0.0494432509820618 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3837587 3784363 504 A239H Transcriptional coactivator YAP1 Homo sapiens 0.128321533869483 0.0497845867418262 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095732 3784363 504 A239H Transcriptional coactivator YAP1 Homo sapiens -0.123424283231215 0.0691026316765555 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3837588 3784364 504 A239I Transcriptional coactivator YAP1 Homo sapiens 0.174389239929808 0.145086212216219 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095733 3784364 504 A239I Transcriptional coactivator YAP1 Homo sapiens -0.361910941234964 0.0668165022951704 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3837589 3784365 504 A239K Transcriptional coactivator YAP1 Homo sapiens -0.0793149053881941 0.0587729638014979 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095734 3784365 504 A239K Transcriptional coactivator YAP1 Homo sapiens -0.0545000055161225 0.0634695507636094 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3837590 3784366 504 A239L Transcriptional coactivator YAP1 Homo sapiens 0.113003613071293 0.0631726951502005 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095735 3784366 504 A239L Transcriptional coactivator YAP1 Homo sapiens -0.144160765897663 0.0463089954015988 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3837591 3784367 504 A239M Transcriptional coactivator YAP1 Homo sapiens 6.23834649536199E-4 0.0748660341597794 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095736 3784367 504 A239M Transcriptional coactivator YAP1 Homo sapiens -0.00725908182210978 0.0625976175133294 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3837592 3784368 504 A239N Transcriptional coactivator YAP1 Homo sapiens 0.110454828819644 0.0886501479506591 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095737 3784368 504 A239N Transcriptional coactivator YAP1 Homo sapiens 0.0754298409045665 0.0847340852836606 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3837593 3784369 504 A239P Transcriptional coactivator YAP1 Homo sapiens 1.10531657354471 0.0921287392065305 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095738 3784369 504 A239P Transcriptional coactivator YAP1 Homo sapiens -1.06031481809549 0.0755519156971947 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3837594 3784370 504 A239Q Transcriptional coactivator YAP1 Homo sapiens 0.0036374883072934 0.120324085681865 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095739 3784370 504 A239Q Transcriptional coactivator YAP1 Homo sapiens -0.0398784021440858 0.0609066644119989 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3837595 3784371 504 A239R Transcriptional coactivator YAP1 Homo sapiens -0.0846428773504859 0.0798235029744216 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095740 3784371 504 A239R Transcriptional coactivator YAP1 Homo sapiens -0.0413193971215978 0.0472991284331651 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3837596 3784372 504 A239S Transcriptional coactivator YAP1 Homo sapiens 0.031778179227393 0.0888282067307144 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095741 3784372 504 A239S Transcriptional coactivator YAP1 Homo sapiens -0.0590807940779864 0.0487465764583123 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3837597 3784373 504 A239T Transcriptional coactivator YAP1 Homo sapiens 0.119933185697565 0.0683429320258461 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095742 3784373 504 A239T Transcriptional coactivator YAP1 Homo sapiens -0.0211176182789424 0.0540874162694691 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3837598 3784374 504 A239V Transcriptional coactivator YAP1 Homo sapiens 0.0652081331313749 0.0904625811929639 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095743 3784374 504 A239V Transcriptional coactivator YAP1 Homo sapiens -0.189901017848115 0.047692963261475 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3837599 3784375 504 A239W Transcriptional coactivator YAP1 Homo sapiens 0.373604421058342 0.0638820934379604 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095744 3784375 504 A239W Transcriptional coactivator YAP1 Homo sapiens -0.476940931415788 0.0626380624469058 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3837600 3784376 504 A239Y Transcriptional coactivator YAP1 Homo sapiens 0.14299287517093 0.0861036941551891 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095745 3784376 504 A239Y Transcriptional coactivator YAP1 Homo sapiens -0.38228299778341 0.0665393713505445 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095066 4906046 503 239A Transcriptional coactivator YAP1 Homo sapiens -1.24379523655518 0.104090522842987 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3838893 3785667 504 M240A Transcriptional coactivator YAP1 Homo sapiens -0.0549978475969746 0.0755966676182565 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095068 3785667 504 M240A Transcriptional coactivator YAP1 Homo sapiens -0.107708605814961 0.0464018524495699 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3838894 3785668 504 M240C Transcriptional coactivator YAP1 Homo sapiens -0.0619864141854118 0.0565382476234799 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095069 3785668 504 M240C Transcriptional coactivator YAP1 Homo sapiens 0.0870723801154741 0.0556962620976193 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3838895 3785669 504 M240D Transcriptional coactivator YAP1 Homo sapiens 0.181481714931367 0.0582046622010295 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095070 3785669 504 M240D Transcriptional coactivator YAP1 Homo sapiens -0.41362046117067 0.0562744026501927 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3838896 3785670 504 M240E Transcriptional coactivator YAP1 Homo sapiens -0.0689731195596916 0.100910749926687 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095071 3785670 504 M240E Transcriptional coactivator YAP1 Homo sapiens -0.0408141338357226 0.0572818021594022 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3838897 3785671 504 M240F Transcriptional coactivator YAP1 Homo sapiens 0.0241019491465114 0.0761886777562607 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095072 3785671 504 M240F Transcriptional coactivator YAP1 Homo sapiens -0.0693237142025088 0.0617995720563193 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3838898 3785672 504 M240G Transcriptional coactivator YAP1 Homo sapiens 0.328569497557721 0.0584375108948264 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095073 3785672 504 M240G Transcriptional coactivator YAP1 Homo sapiens -0.384530822637894 0.0480980809770191 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3838899 3785673 504 M240H Transcriptional coactivator YAP1 Homo sapiens -0.00562984041853039 0.114466504893473 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095074 3785673 504 M240H Transcriptional coactivator YAP1 Homo sapiens -0.0195811404757534 0.0682795060640009 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3838900 3785674 504 M240I Transcriptional coactivator YAP1 Homo sapiens -0.0312058164891408 0.0818762511474852 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095075 3785674 504 M240I Transcriptional coactivator YAP1 Homo sapiens -0.105818045866552 0.0703236660513157 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3838901 3785675 504 M240K Transcriptional coactivator YAP1 Homo sapiens -0.125105290539052 0.0693520049227336 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095076 3785675 504 M240K Transcriptional coactivator YAP1 Homo sapiens 0.0379027033427818 0.0617082825180697 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3838902 3785676 504 M240L Transcriptional coactivator YAP1 Homo sapiens -0.0853797943759856 0.118776436597559 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095077 3785676 504 M240L Transcriptional coactivator YAP1 Homo sapiens 0.0339696066150947 0.0471699162993174 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3838903 3785677 504 M240N Transcriptional coactivator YAP1 Homo sapiens -0.0356745804284842 0.0548974680639 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095718 3785677 504 M240N Transcriptional coactivator YAP1 Homo sapiens -0.00774524854284941 0.0680273597920938 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3838904 3785678 504 M240P Transcriptional coactivator YAP1 Homo sapiens 0.383696106515751 0.0469899748096254 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095719 3785678 504 M240P Transcriptional coactivator YAP1 Homo sapiens -0.375985109739784 0.0578325630117126 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3838905 3785679 504 M240Q Transcriptional coactivator YAP1 Homo sapiens -0.100755241770402 0.0984576269064428 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095720 3785679 504 M240Q Transcriptional coactivator YAP1 Homo sapiens 0.0641143303716033 0.0579867041199642 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3838906 3785680 504 M240R Transcriptional coactivator YAP1 Homo sapiens -0.115999643484091 0.0917732292979585 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095721 3785680 504 M240R Transcriptional coactivator YAP1 Homo sapiens 0.0407719622543818 0.0458664722890957 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3838907 3785681 504 M240S Transcriptional coactivator YAP1 Homo sapiens -0.070532871037144 0.105901105067661 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095722 3785681 504 M240S Transcriptional coactivator YAP1 Homo sapiens 0.0549209256393161 0.0489524374304723 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3838908 3785682 504 M240T Transcriptional coactivator YAP1 Homo sapiens -0.0937720877817824 0.0599557282643264 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095723 3785682 504 M240T Transcriptional coactivator YAP1 Homo sapiens 0.0943481714320774 0.0551385866973494 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3838909 3785683 504 M240V Transcriptional coactivator YAP1 Homo sapiens -0.121235613627578 0.0694276091522377 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095724 3785683 504 M240V Transcriptional coactivator YAP1 Homo sapiens -0.0607565176686214 0.0458793704274642 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3838910 3785684 504 M240W Transcriptional coactivator YAP1 Homo sapiens -0.0785794602297548 0.073427745473234 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095725 3785684 504 M240W Transcriptional coactivator YAP1 Homo sapiens -0.0889390693574633 0.0471459182824638 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3838911 3785685 504 M240Y Transcriptional coactivator YAP1 Homo sapiens -0.01542388960014 0.137640331580861 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095726 3785685 504 M240Y Transcriptional coactivator YAP1 Homo sapiens 0.00603053613172971 0.060235929389225 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095067 4906047 503 240M Transcriptional coactivator YAP1 Homo sapiens -1.10174553227802 0.0809640254808174 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3840204 3786977 504 T241A Transcriptional coactivator YAP1 Homo sapiens 0.160977076397465 0.0616533041130062 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095079 3786977 504 T241A Transcriptional coactivator YAP1 Homo sapiens -0.141530214050256 0.0493201895335681 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3840205 3786978 504 T241C Transcriptional coactivator YAP1 Homo sapiens 0.212613312411456 0.0772782239719266 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095080 3786978 504 T241C Transcriptional coactivator YAP1 Homo sapiens -0.38125655740738 0.0515472548303697 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3840206 3786979 504 T241D Transcriptional coactivator YAP1 Homo sapiens -0.146346706563656 0.128946447213028 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095081 3786979 504 T241D Transcriptional coactivator YAP1 Homo sapiens -0.743554840638508 0.0859556289001576 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3840207 3786980 504 T241E Transcriptional coactivator YAP1 Homo sapiens 0.334352978616808 0.0665006169564842 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095082 3786980 504 T241E Transcriptional coactivator YAP1 Homo sapiens -0.68569797724766 0.0532941131261342 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3840208 3786981 504 T241F Transcriptional coactivator YAP1 Homo sapiens 0.517847786831933 0.0647672211748773 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095083 3786981 504 T241F Transcriptional coactivator YAP1 Homo sapiens -0.679621370652541 0.0656690294806924 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3840209 3786982 504 T241G Transcriptional coactivator YAP1 Homo sapiens 0.257675985332345 0.0854754724865995 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095084 3786982 504 T241G Transcriptional coactivator YAP1 Homo sapiens -0.457874841215542 0.0429277894063261 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3840210 3786983 504 T241H Transcriptional coactivator YAP1 Homo sapiens 0.244987242209658 0.117303973138363 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095085 3786983 504 T241H Transcriptional coactivator YAP1 Homo sapiens -0.587540677623233 0.0930809551972979 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3840211 3786984 504 T241I Transcriptional coactivator YAP1 Homo sapiens 0.579655862042413 0.108131799492718 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095086 3786984 504 T241I Transcriptional coactivator YAP1 Homo sapiens -0.758059000134961 0.067552579398316 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3840212 3786985 504 T241K Transcriptional coactivator YAP1 Homo sapiens 0.407207551149738 0.12745035286066 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095087 3786985 504 T241K Transcriptional coactivator YAP1 Homo sapiens -0.597452192773635 0.0694514145249501 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3840213 3786986 504 T241L Transcriptional coactivator YAP1 Homo sapiens 0.333924055400113 0.119989562256991 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095088 3786986 504 T241L Transcriptional coactivator YAP1 Homo sapiens -0.395537605367834 0.0477099432906413 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3840214 3786987 504 T241M Transcriptional coactivator YAP1 Homo sapiens 0.286326980439272 0.0700455660109455 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095089 3786987 504 T241M Transcriptional coactivator YAP1 Homo sapiens -0.482448301231828 0.0597742778839779 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3840215 3786988 504 T241N Transcriptional coactivator YAP1 Homo sapiens 0.0324058315039852 0.0920319650725856 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095090 3786988 504 T241N Transcriptional coactivator YAP1 Homo sapiens -0.0329169084620035 0.0817617049203291 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3840216 3786989 504 T241P Transcriptional coactivator YAP1 Homo sapiens 0.810717092574094 0.146486196350212 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095091 3786989 504 T241P Transcriptional coactivator YAP1 Homo sapiens -0.866418400975933 0.0613999764308602 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3840217 3786990 504 T241Q Transcriptional coactivator YAP1 Homo sapiens 0.386762631258724 0.171326901230768 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095092 3786990 504 T241Q Transcriptional coactivator YAP1 Homo sapiens -0.691708859831104 0.0577280331883025 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3840218 3786991 504 T241R Transcriptional coactivator YAP1 Homo sapiens 0.674283905786132 0.0659098209962768 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095093 3786991 504 T241R Transcriptional coactivator YAP1 Homo sapiens -0.518320084872456 0.0435997975334423 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3840219 3786992 504 T241S Transcriptional coactivator YAP1 Homo sapiens -0.0332787229393612 0.0953965879065276 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095094 3786992 504 T241S Transcriptional coactivator YAP1 Homo sapiens -0.0722781119670046 0.0457100555068321 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3840220 3786993 504 T241V Transcriptional coactivator YAP1 Homo sapiens 0.537370820569059 0.0924552281277252 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095715 3786993 504 T241V Transcriptional coactivator YAP1 Homo sapiens -0.639161796376167 0.0497027176039374 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3840221 3786994 504 T241W Transcriptional coactivator YAP1 Homo sapiens 0.682760644751321 0.146408416953256 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095716 3786994 504 T241W Transcriptional coactivator YAP1 Homo sapiens -0.564083013994007 0.0466076497665129 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3840222 3786995 504 T241Y Transcriptional coactivator YAP1 Homo sapiens 0.731952321130641 0.0586749338543731 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095717 3786995 504 T241Y Transcriptional coactivator YAP1 Homo sapiens -0.574107676292835 0.065140754833829 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095078 4906048 503 241T Transcriptional coactivator YAP1 Homo sapiens -1.20077447074735 0.0781183906116703 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3841515 3788285 504 Q242A Transcriptional coactivator YAP1 Homo sapiens -0.123401761955854 0.114301122399684 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095096 3788285 504 Q242A Transcriptional coactivator YAP1 Homo sapiens 0.024249454961155 0.0518302340980684 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3841516 3788286 504 Q242C Transcriptional coactivator YAP1 Homo sapiens 0.0525002771172337 0.0996746977997548 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095097 3788286 504 Q242C Transcriptional coactivator YAP1 Homo sapiens -0.0150655985114354 0.053551081280738 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3841517 3788287 504 Q242D Transcriptional coactivator YAP1 Homo sapiens -0.197849698098573 0.124798274599112 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095098 3788287 504 Q242D Transcriptional coactivator YAP1 Homo sapiens 0.0468558096304479 0.0539023068980895 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3841518 3788288 504 Q242E Transcriptional coactivator YAP1 Homo sapiens -0.173284326881896 0.0811246987221473 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095099 3788288 504 Q242E Transcriptional coactivator YAP1 Homo sapiens -0.0354853964727203 0.0673968548665386 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3841519 3788289 504 Q242F Transcriptional coactivator YAP1 Homo sapiens 0.244098124227637 0.106412560866682 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095100 3788289 504 Q242F Transcriptional coactivator YAP1 Homo sapiens -0.163185718913846 0.0480489391494039 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3841520 3788290 504 Q242G Transcriptional coactivator YAP1 Homo sapiens -0.0931748113304425 0.0964102857067933 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095101 3788290 504 Q242G Transcriptional coactivator YAP1 Homo sapiens -0.00837702657274699 0.0474301467837985 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3841521 3788291 504 Q242H Transcriptional coactivator YAP1 Homo sapiens -0.0794724379243274 0.0951571169362393 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095102 3788291 504 Q242H Transcriptional coactivator YAP1 Homo sapiens 0.011184221647657 0.0468006842124236 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3841522 3788292 504 Q242I Transcriptional coactivator YAP1 Homo sapiens -0.0381683148265668 0.0731131170098507 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095103 3788292 504 Q242I Transcriptional coactivator YAP1 Homo sapiens -0.020383196211442 0.0491779360371134 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3841523 3788293 504 Q242K Transcriptional coactivator YAP1 Homo sapiens -0.223114735050865 0.106017398319367 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095104 3788293 504 Q242K Transcriptional coactivator YAP1 Homo sapiens 0.0246648052528509 0.0614456410922403 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3841524 3788294 504 Q242L Transcriptional coactivator YAP1 Homo sapiens 0.0652752876286488 0.0817770081478442 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095105 3788294 504 Q242L Transcriptional coactivator YAP1 Homo sapiens -0.0796668912939925 0.0457709576358099 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3841525 3788295 504 Q242M Transcriptional coactivator YAP1 Homo sapiens -0.059012079183108 0.0470585910464342 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095106 3788295 504 Q242M Transcriptional coactivator YAP1 Homo sapiens -0.0338852634524132 0.0567675396172069 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3841526 3788296 504 Q242N Transcriptional coactivator YAP1 Homo sapiens -0.161294731865735 0.103657025429544 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095107 3788296 504 Q242N Transcriptional coactivator YAP1 Homo sapiens 0.0388909505885408 0.0526510999504154 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3841527 3788297 504 Q242P Transcriptional coactivator YAP1 Homo sapiens -0.137037338703935 0.113482109400741 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095108 3788297 504 Q242P Transcriptional coactivator YAP1 Homo sapiens 0.0217446221675562 0.0494213376735688 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3841528 3788298 504 Q242R Transcriptional coactivator YAP1 Homo sapiens -0.0670837362522525 0.0693585281745299 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095709 3788298 504 Q242R Transcriptional coactivator YAP1 Homo sapiens -0.059814420455273 0.0478735292417327 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3841529 3788299 504 Q242S Transcriptional coactivator YAP1 Homo sapiens -0.181120758664559 0.0894702074605849 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095710 3788299 504 Q242S Transcriptional coactivator YAP1 Homo sapiens 0.0687349034441663 0.0444111787584386 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3841530 3788300 504 Q242T Transcriptional coactivator YAP1 Homo sapiens -0.147102591319409 0.0866976060174535 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095711 3788300 504 Q242T Transcriptional coactivator YAP1 Homo sapiens 0.0623972308898416 0.0474161665067389 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3841531 3788301 504 Q242V Transcriptional coactivator YAP1 Homo sapiens 0.017493352691641 0.0714744878615495 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095712 3788301 504 Q242V Transcriptional coactivator YAP1 Homo sapiens -0.053901646475212 0.0468401743177433 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3841532 3788302 504 Q242W Transcriptional coactivator YAP1 Homo sapiens 0.293354538001444 0.0563915594167515 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095713 3788302 504 Q242W Transcriptional coactivator YAP1 Homo sapiens -0.27634321131412 0.0665568128800348 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3841533 3788303 504 Q242Y Transcriptional coactivator YAP1 Homo sapiens 0.101127619635577 0.0454425260252709 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095714 3788303 504 Q242Y Transcriptional coactivator YAP1 Homo sapiens -0.182399250510742 0.048918262535782 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095095 4906049 503 242Q Transcriptional coactivator YAP1 Homo sapiens -1.24043963587099 0.0890255608837227 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3842826 3789594 504 D243A Transcriptional coactivator YAP1 Homo sapiens -0.0883061946741292 0.0837643482591674 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095110 3789594 504 D243A Transcriptional coactivator YAP1 Homo sapiens 0.0157331826009621 0.0467345464418379 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3842827 3789595 504 D243C Transcriptional coactivator YAP1 Homo sapiens -0.0155767961076147 0.084497029728386 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095111 3789595 504 D243C Transcriptional coactivator YAP1 Homo sapiens -0.0868838015347614 0.0449027323019271 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3842828 3789596 504 D243E Transcriptional coactivator YAP1 Homo sapiens -0.160239207384554 0.115830277496881 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095692 3789596 504 D243E Transcriptional coactivator YAP1 Homo sapiens 0.0314918272887713 0.0673634915758666 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3842829 3789597 504 D243F Transcriptional coactivator YAP1 Homo sapiens 0.167834649068082 0.0801609071177009 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095693 3789597 504 D243F Transcriptional coactivator YAP1 Homo sapiens -0.194018714705445 0.0449270804224747 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3842830 3789598 504 D243G Transcriptional coactivator YAP1 Homo sapiens -0.117660940285347 0.0950031785464294 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095694 3789598 504 D243G Transcriptional coactivator YAP1 Homo sapiens -0.0332383673084501 0.047967707135459 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3842831 3789599 504 D243H Transcriptional coactivator YAP1 Homo sapiens 0.0182910978867282 0.069904916060063 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095695 3789599 504 D243H Transcriptional coactivator YAP1 Homo sapiens -0.0194116584601763 0.0444603603705646 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3842832 3789600 504 D243I Transcriptional coactivator YAP1 Homo sapiens 0.136478389310759 0.0984567773195693 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095696 3789600 504 D243I Transcriptional coactivator YAP1 Homo sapiens -0.12627444557768 0.0462829763316018 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3842833 3789601 504 D243K Transcriptional coactivator YAP1 Homo sapiens -0.144500053537476 0.0792329782068454 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095697 3789601 504 D243K Transcriptional coactivator YAP1 Homo sapiens 0.0338088771918714 0.0695899839757141 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3842834 3789602 504 D243L Transcriptional coactivator YAP1 Homo sapiens 0.0907682130377322 0.096985517910645 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095698 3789602 504 D243L Transcriptional coactivator YAP1 Homo sapiens -0.118489412524131 0.0431847018626149 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3842835 3789603 504 D243M Transcriptional coactivator YAP1 Homo sapiens 0.0667438598674351 0.0871503514250274 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095699 3789603 504 D243M Transcriptional coactivator YAP1 Homo sapiens -0.0156408825361406 0.0545294460540395 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3842836 3789604 504 D243N Transcriptional coactivator YAP1 Homo sapiens -0.0701642369806162 0.114356092358326 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095700 3789604 504 D243N Transcriptional coactivator YAP1 Homo sapiens 0.0336807710674213 0.0474146069539195 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3842837 3789605 504 D243P Transcriptional coactivator YAP1 Homo sapiens 0.413446219475359 0.04440973108748 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095701 3789605 504 D243P Transcriptional coactivator YAP1 Homo sapiens -0.411729105532047 0.0487784358944799 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3842838 3789606 504 D243Q Transcriptional coactivator YAP1 Homo sapiens -0.0627398503305198 0.0730816204050935 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095702 3789606 504 D243Q Transcriptional coactivator YAP1 Homo sapiens -0.0315244505875441 0.0548113113554387 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3842839 3789607 504 D243R Transcriptional coactivator YAP1 Homo sapiens -0.0132594224411209 0.0978500597637666 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095703 3789607 504 D243R Transcriptional coactivator YAP1 Homo sapiens -0.109684304616265 0.0454894663088114 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3842840 3789608 504 D243S Transcriptional coactivator YAP1 Homo sapiens -0.0496322575033133 0.0614081504755502 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095704 3789608 504 D243S Transcriptional coactivator YAP1 Homo sapiens 0.0190806513311622 0.0428176977083203 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3842841 3789609 504 D243T Transcriptional coactivator YAP1 Homo sapiens -0.0691952049442886 0.0799230047886069 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095705 3789609 504 D243T Transcriptional coactivator YAP1 Homo sapiens 0.0176030546038073 0.0460034185318232 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3842842 3789610 504 D243V Transcriptional coactivator YAP1 Homo sapiens 0.084043991747849 0.0744221334579358 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095706 3789610 504 D243V Transcriptional coactivator YAP1 Homo sapiens -0.144950886280141 0.0470123218955371 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3842843 3789611 504 D243W Transcriptional coactivator YAP1 Homo sapiens 0.227674878528826 0.0829090112015767 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095707 3789611 504 D243W Transcriptional coactivator YAP1 Homo sapiens -0.426430437063524 0.0618333411490005 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3842844 3789612 504 D243Y Transcriptional coactivator YAP1 Homo sapiens 0.139337119733102 0.103349126144312 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095708 3789612 504 D243Y Transcriptional coactivator YAP1 Homo sapiens -0.106089376229518 0.0452611668726172 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095109 4906050 503 243D Transcriptional coactivator YAP1 Homo sapiens -1.14195581681036 0.0755142079379544 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 3.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3844308 3791072 504 G244A Transcriptional coactivator YAP1 Homo sapiens 0.244967223467299 0.0702026911954918 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095113 3791072 504 G244A Transcriptional coactivator YAP1 Homo sapiens -0.394208007020279 1.19288205929943 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3844309 3791073 504 G244C Transcriptional coactivator YAP1 Homo sapiens 0.309450732138746 0.0654588006439045 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095114 3791073 504 G244C Transcriptional coactivator YAP1 Homo sapiens -0.460322543451777 0.342179017463662 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3844310 3791074 504 G244D Transcriptional coactivator YAP1 Homo sapiens 0.11894659590761 0.089766870818754 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095115 3791074 504 G244D Transcriptional coactivator YAP1 Homo sapiens -0.219149794423686 0.344544684038836 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3844311 3791075 504 G244E Transcriptional coactivator YAP1 Homo sapiens 0.156358440832498 0.0864873585850552 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095116 3791075 504 G244E Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3844312 3791076 504 G244F Transcriptional coactivator YAP1 Homo sapiens 0.480028128954918 0.19109406459998 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095117 3791076 504 G244F Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3844313 3791077 504 G244H Transcriptional coactivator YAP1 Homo sapiens 0.165451079643409 0.0863656099728689 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095678 3791077 504 G244H Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3844314 3791078 504 G244I Transcriptional coactivator YAP1 Homo sapiens 0.993287685304434 0.146329287219546 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095679 3791078 504 G244I Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3844315 3791079 504 G244K Transcriptional coactivator YAP1 Homo sapiens 0.19898653535788 0.201245750020435 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095680 3791079 504 G244K Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3844316 3791080 504 G244L Transcriptional coactivator YAP1 Homo sapiens 0.48352860691899 0.120796478489191 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095681 3791080 504 G244L Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3844317 3791081 504 G244M Transcriptional coactivator YAP1 Homo sapiens 0.222134255534716 0.157058016545663 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095682 3791081 504 G244M Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3844318 3791082 504 G244N Transcriptional coactivator YAP1 Homo sapiens 1.38915555851709E-4 0.117780159266684 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095683 3791082 504 G244N Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3844319 3791083 504 G244P Transcriptional coactivator YAP1 Homo sapiens 0.756779207565094 0.0967338826567759 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095684 3791083 504 G244P Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3844320 3791084 504 G244Q Transcriptional coactivator YAP1 Homo sapiens 0.12831351061861 0.0989008580663132 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095685 3791084 504 G244Q Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3844321 3791085 504 G244R Transcriptional coactivator YAP1 Homo sapiens 0.31275847203698 0.118085058553764 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095686 3791085 504 G244R Transcriptional coactivator YAP1 Homo sapiens -0.224663131916331 0.271965960308991 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3844322 3791086 504 G244S Transcriptional coactivator YAP1 Homo sapiens 0.269181000751987 0.104896432018026 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095687 3791086 504 G244S Transcriptional coactivator YAP1 Homo sapiens -0.254272356158833 0.145409919964585 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3844323 3791087 504 G244T Transcriptional coactivator YAP1 Homo sapiens 0.453976070731917 0.091582449220412 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095688 3791087 504 G244T Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3844324 3791088 504 G244V Transcriptional coactivator YAP1 Homo sapiens 0.866498828660511 0.0765824359533534 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095689 3791088 504 G244V Transcriptional coactivator YAP1 Homo sapiens -0.453712187861123 0.575370197955352 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3844325 3791089 504 G244W Transcriptional coactivator YAP1 Homo sapiens 0.708512916962412 0.120745176945394 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095690 3791089 504 G244W Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3844326 3791090 504 G244Y Transcriptional coactivator YAP1 Homo sapiens 0.377288027191695 0.0545272057263046 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095691 3791090 504 G244Y Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095112 4906051 503 244G Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3845600 3792363 504 E245A Transcriptional coactivator YAP1 Homo sapiens -0.0686585721165133 0.0809787948360161 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095119 3792363 504 E245A Transcriptional coactivator YAP1 Homo sapiens -0.247275056417122 0.0485907166591985 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3845601 3792364 504 E245C Transcriptional coactivator YAP1 Homo sapiens 0.0828462092897691 0.0863191291312791 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095120 3792364 504 E245C Transcriptional coactivator YAP1 Homo sapiens -0.345306477849697 0.0543709366065132 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3845602 3792365 504 E245D Transcriptional coactivator YAP1 Homo sapiens -0.0803155600607091 0.101010657967179 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095121 3792365 504 E245D Transcriptional coactivator YAP1 Homo sapiens -0.0782593153054676 0.0553532082187654 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3845603 3792366 504 E245F Transcriptional coactivator YAP1 Homo sapiens 0.345619389532244 0.0982088059794226 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095662 3792366 504 E245F Transcriptional coactivator YAP1 Homo sapiens -0.610033009884863 0.0490856280153899 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3845604 3792367 504 E245G Transcriptional coactivator YAP1 Homo sapiens 0.102800862415973 0.0736721170406541 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095663 3792367 504 E245G Transcriptional coactivator YAP1 Homo sapiens -0.422050003297539 0.0510323955205139 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3845605 3792368 504 E245H Transcriptional coactivator YAP1 Homo sapiens 0.0541983964764565 0.0985013046739901 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095664 3792368 504 E245H Transcriptional coactivator YAP1 Homo sapiens -0.200575997758827 0.0501040637478673 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3845606 3792369 504 E245I Transcriptional coactivator YAP1 Homo sapiens 0.1830227754976 0.113611511046474 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095665 3792369 504 E245I Transcriptional coactivator YAP1 Homo sapiens -0.480491539857617 0.051740543897149 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3845607 3792370 504 E245K Transcriptional coactivator YAP1 Homo sapiens -0.0418597562889273 0.0787270407840207 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095666 3792370 504 E245K Transcriptional coactivator YAP1 Homo sapiens -0.201183905082305 0.0632976896342925 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3845608 3792371 504 E245L Transcriptional coactivator YAP1 Homo sapiens 0.14552960654178 0.0589292022649099 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095667 3792371 504 E245L Transcriptional coactivator YAP1 Homo sapiens -0.340498121886636 0.0459554065843119 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3845609 3792372 504 E245M Transcriptional coactivator YAP1 Homo sapiens 0.108595747068936 0.0774012756590793 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095668 3792372 504 E245M Transcriptional coactivator YAP1 Homo sapiens -0.293345519806374 0.0580164549770648 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3845610 3792373 504 E245N Transcriptional coactivator YAP1 Homo sapiens 0.00236858653817738 0.104825573096928 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095669 3792373 504 E245N Transcriptional coactivator YAP1 Homo sapiens -0.143433505042088 0.0530921589929248 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3845611 3792374 504 E245P Transcriptional coactivator YAP1 Homo sapiens 0.580766041403661 0.101626006425393 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095670 3792374 504 E245P Transcriptional coactivator YAP1 Homo sapiens -1.00071833718983 0.0572033311904998 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3845612 3792375 504 E245Q Transcriptional coactivator YAP1 Homo sapiens -0.102953623762247 0.0970437849415248 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095671 3792375 504 E245Q Transcriptional coactivator YAP1 Homo sapiens -0.311567621396656 0.0632784498449186 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3845613 3792376 504 E245R Transcriptional coactivator YAP1 Homo sapiens -0.0549303487638287 0.0804850442023846 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095672 3792376 504 E245R Transcriptional coactivator YAP1 Homo sapiens -0.254198356968933 0.0469973708764165 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3845614 3792377 504 E245S Transcriptional coactivator YAP1 Homo sapiens -0.0312736270250204 0.06513588223814 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095673 3792377 504 E245S Transcriptional coactivator YAP1 Homo sapiens -0.222347673393658 0.0436207639705806 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3845615 3792378 504 E245T Transcriptional coactivator YAP1 Homo sapiens -0.0221614724721914 0.0987424815697094 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095674 3792378 504 E245T Transcriptional coactivator YAP1 Homo sapiens -0.337678195768302 0.0464241954307784 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3845616 3792379 504 E245V Transcriptional coactivator YAP1 Homo sapiens 0.0668786966185972 0.095090144734427 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095675 3792379 504 E245V Transcriptional coactivator YAP1 Homo sapiens -0.478306494961015 0.0462233632207707 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3845617 3792380 504 E245W Transcriptional coactivator YAP1 Homo sapiens 0.401179479093509 0.0789844037162825 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095676 3792380 504 E245W Transcriptional coactivator YAP1 Homo sapiens -0.639722041855827 0.09285108029448 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3845618 3792381 504 E245Y Transcriptional coactivator YAP1 Homo sapiens 0.325095677491709 0.113239723953628 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095677 3792381 504 E245Y Transcriptional coactivator YAP1 Homo sapiens -0.440116786158052 0.0518313878488787 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095118 4906052 503 245E Transcriptional coactivator YAP1 Homo sapiens -1.31674110766356 0.119440182760812 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3846835 3793596 504 I246A Transcriptional coactivator YAP1 Homo sapiens -0.0326745935290013 0.0706691200154932 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095123 3793596 504 I246A Transcriptional coactivator YAP1 Homo sapiens -0.0207627404435088 0.0468292972325182 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3846836 3793597 504 I246C Transcriptional coactivator YAP1 Homo sapiens -0.00616247613698957 0.0986286301769652 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095124 3793597 504 I246C Transcriptional coactivator YAP1 Homo sapiens -0.112807388706124 0.0535829327600035 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3846837 3793598 504 I246D Transcriptional coactivator YAP1 Homo sapiens 0.292410472566393 0.0658723243952151 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095125 3793598 504 I246D Transcriptional coactivator YAP1 Homo sapiens -0.283949214069523 0.0634301083997026 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3846838 3793599 504 I246E Transcriptional coactivator YAP1 Homo sapiens 0.0981491593544937 0.0825217008624783 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095126 3793599 504 I246E Transcriptional coactivator YAP1 Homo sapiens -0.12326912363949 0.0516693216660959 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3846839 3793600 504 I246F Transcriptional coactivator YAP1 Homo sapiens 0.201704999550034 0.0622783491143851 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095127 3793600 504 I246F Transcriptional coactivator YAP1 Homo sapiens -0.189940802358814 0.062966499496529 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3846840 3793601 504 I246G Transcriptional coactivator YAP1 Homo sapiens 0.241082709730754 0.0833979523858073 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095128 3793601 504 I246G Transcriptional coactivator YAP1 Homo sapiens -0.303147627552354 0.0438721463798823 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3846841 3793602 504 I246H Transcriptional coactivator YAP1 Homo sapiens 0.0835180130770527 0.0765930698552811 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095129 3793602 504 I246H Transcriptional coactivator YAP1 Homo sapiens -0.0759717059402846 0.0598891596370719 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3846842 3793603 504 I246K Transcriptional coactivator YAP1 Homo sapiens -0.116169864684577 0.0956443184366201 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095650 3793603 504 I246K Transcriptional coactivator YAP1 Homo sapiens -0.0329558972824884 0.0497548114422465 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3846843 3793604 504 I246L Transcriptional coactivator YAP1 Homo sapiens 0.00478946610491247 0.0757361394003222 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095651 3793604 504 I246L Transcriptional coactivator YAP1 Homo sapiens -0.104258493047157 0.0466890568323048 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3846844 3793605 504 I246M Transcriptional coactivator YAP1 Homo sapiens -0.0142414976051991 0.0692173032052469 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095652 3793605 504 I246M Transcriptional coactivator YAP1 Homo sapiens -0.123965352576719 0.0538621324991858 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3846845 3793606 504 I246N Transcriptional coactivator YAP1 Homo sapiens 0.104737609910294 0.0628793536204431 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095653 3793606 504 I246N Transcriptional coactivator YAP1 Homo sapiens -0.119320908797737 0.0795658465937196 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3846846 3793607 504 I246P Transcriptional coactivator YAP1 Homo sapiens 0.0430623099368669 0.0637163632324575 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095654 3793607 504 I246P Transcriptional coactivator YAP1 Homo sapiens -0.0393922354233462 0.0524749023094324 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3846847 3793608 504 I246Q Transcriptional coactivator YAP1 Homo sapiens -0.0561706386976036 0.0744498671242754 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095655 3793608 504 I246Q Transcriptional coactivator YAP1 Homo sapiens -0.0766798702307239 0.0561965364058529 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3846848 3793609 504 I246R Transcriptional coactivator YAP1 Homo sapiens 0.0665174680338775 0.0878926990548343 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095656 3793609 504 I246R Transcriptional coactivator YAP1 Homo sapiens 0.00637745706502361 0.0428681603816907 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3846849 3793610 504 I246S Transcriptional coactivator YAP1 Homo sapiens 0.0252573119007854 0.0563055092071845 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095657 3793610 504 I246S Transcriptional coactivator YAP1 Homo sapiens -0.16217200958124 0.0458190650661469 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3846850 3793611 504 I246T Transcriptional coactivator YAP1 Homo sapiens -0.0975591634688123 0.0890467193493199 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095658 3793611 504 I246T Transcriptional coactivator YAP1 Homo sapiens 0.0223008096271259 0.0489728946258737 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3846851 3793612 504 I246V Transcriptional coactivator YAP1 Homo sapiens -0.0731272505345291 0.10119303219844 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095659 3793612 504 I246V Transcriptional coactivator YAP1 Homo sapiens 0.0213603037942055 0.051218730254823 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3846852 3793613 504 I246W Transcriptional coactivator YAP1 Homo sapiens 0.246504413068175 0.085292704407119 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095660 3793613 504 I246W Transcriptional coactivator YAP1 Homo sapiens -0.174907031455938 0.049107891427577 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3846853 3793614 504 I246Y Transcriptional coactivator YAP1 Homo sapiens 0.176485423935084 0.158714215825678 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095661 3793614 504 I246Y Transcriptional coactivator YAP1 Homo sapiens -0.121527357761094 0.0718372200194401 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095122 4906053 503 246I Transcriptional coactivator YAP1 Homo sapiens -1.2550112937683 0.0860936015832612 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3848146 3794906 504 Y247A Transcriptional coactivator YAP1 Homo sapiens 0.477530050973615 0.122519947045104 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095131 3794906 504 Y247A Transcriptional coactivator YAP1 Homo sapiens -0.724855484057883 0.0462499392739175 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3848147 3794907 504 Y247C Transcriptional coactivator YAP1 Homo sapiens 0.337744765725092 0.131708943636127 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095132 3794907 504 Y247C Transcriptional coactivator YAP1 Homo sapiens -0.664043188505262 0.0567244689059243 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3848148 3794908 504 Y247D Transcriptional coactivator YAP1 Homo sapiens 0.603726559895345 0.0587631963656532 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095133 3794908 504 Y247D Transcriptional coactivator YAP1 Homo sapiens -0.710971008100075 0.0603969293471211 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3848149 3794909 504 Y247E Transcriptional coactivator YAP1 Homo sapiens 0.390020318674657 0.103165682896455 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095134 3794909 504 Y247E Transcriptional coactivator YAP1 Homo sapiens -0.674575580729629 0.0497494087056936 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3848150 3794910 504 Y247F Transcriptional coactivator YAP1 Homo sapiens 0.065694771991442 0.0856505098881706 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095135 3794910 504 Y247F Transcriptional coactivator YAP1 Homo sapiens -0.169402446555647 0.0699366105036288 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3848151 3794911 504 Y247G Transcriptional coactivator YAP1 Homo sapiens 0.627587010315877 0.150398605793507 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095136 3794911 504 Y247G Transcriptional coactivator YAP1 Homo sapiens -0.863075467679953 0.0440355572791266 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3848152 3794912 504 Y247H Transcriptional coactivator YAP1 Homo sapiens 0.350048381553097 0.145613912566375 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095137 3794912 504 Y247H Transcriptional coactivator YAP1 Homo sapiens -0.564068214156027 0.0863586459935368 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3848153 3794913 504 Y247I Transcriptional coactivator YAP1 Homo sapiens 0.325907713750763 0.101899967246907 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095138 3794913 504 Y247I Transcriptional coactivator YAP1 Homo sapiens -1.03150056794577 0.152659453504127 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3848154 3794914 504 Y247K Transcriptional coactivator YAP1 Homo sapiens 0.449246347463427 0.0839029603268339 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095139 3794914 504 Y247K Transcriptional coactivator YAP1 Homo sapiens -0.822455084411333 0.0672039716017685 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3848155 3794915 504 Y247L Transcriptional coactivator YAP1 Homo sapiens 0.359797058969703 0.0494493375109482 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095140 3794915 504 Y247L Transcriptional coactivator YAP1 Homo sapiens -0.78971354607249 0.0478570664112055 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3848156 3794916 504 Y247M Transcriptional coactivator YAP1 Homo sapiens 0.323828217657189 0.111219557155847 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095141 3794916 504 Y247M Transcriptional coactivator YAP1 Homo sapiens -0.810932773991758 0.0557217082706623 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3848157 3794917 504 Y247N Transcriptional coactivator YAP1 Homo sapiens 0.660553963004648 0.142035092565033 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095142 3794917 504 Y247N Transcriptional coactivator YAP1 Homo sapiens -0.853551692370822 0.0830884387831139 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3848158 3794918 504 Y247P Transcriptional coactivator YAP1 Homo sapiens 0.796469239383912 0.147680850528148 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095143 3794918 504 Y247P Transcriptional coactivator YAP1 Homo sapiens -0.928583369892315 0.0605410606724808 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3848159 3794919 504 Y247Q Transcriptional coactivator YAP1 Homo sapiens 0.365343173333274 0.0683433900150614 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095144 3794919 504 Y247Q Transcriptional coactivator YAP1 Homo sapiens -0.699151905230686 0.0548642884098852 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3848160 3794920 504 Y247R Transcriptional coactivator YAP1 Homo sapiens 0.560986893795769 0.100314480601509 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095145 3794920 504 Y247R Transcriptional coactivator YAP1 Homo sapiens -0.803879537228004 0.0436940868237985 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3848161 3794921 504 Y247S Transcriptional coactivator YAP1 Homo sapiens 0.488590996899318 0.124882079873828 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095146 3794921 504 Y247S Transcriptional coactivator YAP1 Homo sapiens -0.930425551875714 0.0522181410342842 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3848162 3794922 504 Y247T Transcriptional coactivator YAP1 Homo sapiens 0.451346379928449 0.0872975268782674 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095147 3794922 504 Y247T Transcriptional coactivator YAP1 Homo sapiens -0.827947893096458 0.0588399863916285 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3848163 3794923 504 Y247V Transcriptional coactivator YAP1 Homo sapiens 0.31705789924641 0.0629177166875878 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095148 3794923 504 Y247V Transcriptional coactivator YAP1 Homo sapiens -0.808112450028317 0.045682723547982 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3848164 3794924 504 Y247W Transcriptional coactivator YAP1 Homo sapiens 0.418485755006148 0.096210435867391 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095149 3794924 504 Y247W Transcriptional coactivator YAP1 Homo sapiens -0.546668856246997 0.0469734603854865 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095130 4906054 503 247Y Transcriptional coactivator YAP1 Homo sapiens -1.18274865797596 0.07416427174853 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095150 4906054 503 247Y Transcriptional coactivator YAP1 Homo sapiens -1.21117407818881 0.0800812867574316 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3849457 3796214 504 Y248A Transcriptional coactivator YAP1 Homo sapiens 0.64078823999464 0.0240387432589586 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095151 3796214 504 Y248A Transcriptional coactivator YAP1 Homo sapiens -0.999962192779483 0.0594507502429749 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3849458 3796215 504 Y248C Transcriptional coactivator YAP1 Homo sapiens 0.914327531385669 0.10025104853255 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095152 3796215 504 Y248C Transcriptional coactivator YAP1 Homo sapiens -0.886868514734371 0.061210108832001 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3849459 3796216 504 Y248D Transcriptional coactivator YAP1 Homo sapiens 0.541326688350179 0.114173920677578 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095153 3796216 504 Y248D Transcriptional coactivator YAP1 Homo sapiens -0.983382634497914 0.0703911803659716 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3849460 3796217 504 Y248E Transcriptional coactivator YAP1 Homo sapiens 0.627813979418397 0.101890193059378 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095154 3796217 504 Y248E Transcriptional coactivator YAP1 Homo sapiens -1.08029857781952 0.0702351136874022 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3849461 3796218 504 Y248F Transcriptional coactivator YAP1 Homo sapiens 0.0498942847237751 0.0805007306143287 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095155 3796218 504 Y248F Transcriptional coactivator YAP1 Homo sapiens 0.0400208306923878 0.0654703695049689 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3849462 3796219 504 Y248G Transcriptional coactivator YAP1 Homo sapiens 0.64212480331248 0.0701089361894699 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095156 3796219 504 Y248G Transcriptional coactivator YAP1 Homo sapiens -0.916201952748708 0.0472256543988065 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3849463 3796220 504 Y248H Transcriptional coactivator YAP1 Homo sapiens 0.734065620654258 0.218673916330619 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095157 3796220 504 Y248H Transcriptional coactivator YAP1 Homo sapiens -0.75773841654775 0.0948963224204858 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3849464 3796221 504 Y248I Transcriptional coactivator YAP1 Homo sapiens 0.841007283970758 0.246857087269566 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095158 3796221 504 Y248I Transcriptional coactivator YAP1 Homo sapiens -0.975187104862975 0.082393960364355 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3849465 3796222 504 Y248K Transcriptional coactivator YAP1 Homo sapiens 0.672237290392486 0.0908172358882591 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095159 3796222 504 Y248K Transcriptional coactivator YAP1 Homo sapiens -0.998968773547333 0.074788164488407 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3849466 3796223 504 Y248L Transcriptional coactivator YAP1 Homo sapiens 0.843511370950611 0.0539496014308906 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095160 3796223 504 Y248L Transcriptional coactivator YAP1 Homo sapiens -0.937514674268118 0.0474984727024727 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3849467 3796224 504 Y248M Transcriptional coactivator YAP1 Homo sapiens 0.955222311149649 0.11663873536354 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095161 3796224 504 Y248M Transcriptional coactivator YAP1 Homo sapiens -1.00144217657748 0.0626811172443841 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3849468 3796225 504 Y248N Transcriptional coactivator YAP1 Homo sapiens 0.856673553391607 0.105344282454872 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095162 3796225 504 Y248N Transcriptional coactivator YAP1 Homo sapiens -0.993696609758544 0.131184729457152 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3849469 3796226 504 Y248P Transcriptional coactivator YAP1 Homo sapiens 0.711373492844983 0.0900840199107424 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095163 3796226 504 Y248P Transcriptional coactivator YAP1 Homo sapiens -0.895624687694078 0.0610700196129283 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3849470 3796227 504 Y248Q Transcriptional coactivator YAP1 Homo sapiens 0.624173696589194 0.0883498668152733 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095164 3796227 504 Y248Q Transcriptional coactivator YAP1 Homo sapiens -1.05590725129321 0.0878143612400073 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3849471 3796228 504 Y248R Transcriptional coactivator YAP1 Homo sapiens 0.806656855014795 0.0793560276434368 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095165 3796228 504 Y248R Transcriptional coactivator YAP1 Homo sapiens -0.943991592609889 0.0471678952461739 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3849472 3796229 504 Y248S Transcriptional coactivator YAP1 Homo sapiens 0.613730417199795 0.0928232173984535 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095166 3796229 504 Y248S Transcriptional coactivator YAP1 Homo sapiens -0.917054136967878 0.0517783153116064 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3849473 3796230 504 Y248T Transcriptional coactivator YAP1 Homo sapiens 0.751459330871635 0.0718225157792307 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095167 3796230 504 Y248T Transcriptional coactivator YAP1 Homo sapiens -0.956884240715975 0.0606785241138475 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3849474 3796231 504 Y248V Transcriptional coactivator YAP1 Homo sapiens 0.791873480774098 0.0764733692538363 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095168 3796231 504 Y248V Transcriptional coactivator YAP1 Homo sapiens -0.865893643279815 0.0498810079101832 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3849475 3796232 504 Y248W Transcriptional coactivator YAP1 Homo sapiens 0.0523744651167023 0.0719373180341049 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095169 3796232 504 Y248W Transcriptional coactivator YAP1 Homo sapiens -0.111247835886729 0.0497996485858041 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3850768 3797523 504 I249A Transcriptional coactivator YAP1 Homo sapiens 0.225053818627768 0.0770469630490948 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095171 3797523 504 I249A Transcriptional coactivator YAP1 Homo sapiens -0.434482981167011 0.0490709077464313 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3850769 3797524 504 I249C Transcriptional coactivator YAP1 Homo sapiens 0.136302778016068 0.0864651612994018 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095172 3797524 504 I249C Transcriptional coactivator YAP1 Homo sapiens -0.399391928764338 0.0595564497309996 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3850770 3797525 504 I249D Transcriptional coactivator YAP1 Homo sapiens 0.60457738457762 0.118341525762646 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095173 3797525 504 I249D Transcriptional coactivator YAP1 Homo sapiens -0.882721934322274 0.0582030522891444 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3850771 3797526 504 I249E Transcriptional coactivator YAP1 Homo sapiens 0.204108497694616 0.0667115755662389 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095174 3797526 504 I249E Transcriptional coactivator YAP1 Homo sapiens -0.458396257012761 0.0520194014895392 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3850772 3797527 504 I249F Transcriptional coactivator YAP1 Homo sapiens 0.194808728478645 0.0740533564907684 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095175 3797527 504 I249F Transcriptional coactivator YAP1 Homo sapiens -0.506901055042654 0.0703717814385548 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3850773 3797528 504 I249G Transcriptional coactivator YAP1 Homo sapiens 0.590519028645069 0.0678870605886896 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095176 3797528 504 I249G Transcriptional coactivator YAP1 Homo sapiens -0.948738282581367 0.0451575998343659 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3850774 3797529 504 I249H Transcriptional coactivator YAP1 Homo sapiens 0.314877938098434 0.053094723487796 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095177 3797529 504 I249H Transcriptional coactivator YAP1 Homo sapiens -0.367793478986894 0.0810840155650851 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3850775 3797530 504 I249K Transcriptional coactivator YAP1 Homo sapiens 0.027485100851262 0.160237463199582 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095638 3797530 504 I249K Transcriptional coactivator YAP1 Homo sapiens -0.314736855518925 0.0703889922178831 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3850776 3797531 504 I249L Transcriptional coactivator YAP1 Homo sapiens 0.00430515241220545 0.0716414412470943 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095639 3797531 504 I249L Transcriptional coactivator YAP1 Homo sapiens -0.0682344142995747 0.0467628650565533 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3850777 3797532 504 I249M Transcriptional coactivator YAP1 Homo sapiens -0.0110581422890211 0.0735138519468324 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095640 3797532 504 I249M Transcriptional coactivator YAP1 Homo sapiens -0.11791492418964 0.0529060947932885 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3850778 3797533 504 I249N Transcriptional coactivator YAP1 Homo sapiens 0.444490720234898 0.0940096750323007 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095641 3797533 504 I249N Transcriptional coactivator YAP1 Homo sapiens -0.5155216423899 0.0815756725483013 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3850779 3797534 504 I249P Transcriptional coactivator YAP1 Homo sapiens 0.734268722554673 0.219955475931399 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095642 3797534 504 I249P Transcriptional coactivator YAP1 Homo sapiens -0.874108428617933 0.0828469468031719 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3850780 3797535 504 I249Q Transcriptional coactivator YAP1 Homo sapiens 0.147929031170492 0.0667432916007184 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095643 3797535 504 I249Q Transcriptional coactivator YAP1 Homo sapiens -0.241307379812296 0.0679064944485907 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3850781 3797536 504 I249R Transcriptional coactivator YAP1 Homo sapiens 0.184323329835369 0.051940532150655 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095644 3797536 504 I249R Transcriptional coactivator YAP1 Homo sapiens -0.253936574888535 0.0438859993465076 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3850782 3797537 504 I249S Transcriptional coactivator YAP1 Homo sapiens 0.354489650385594 0.0437086452477136 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095645 3797537 504 I249S Transcriptional coactivator YAP1 Homo sapiens -0.626085900813801 0.0520215975945298 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3850783 3797538 504 I249T Transcriptional coactivator YAP1 Homo sapiens 0.169983068600076 0.0679472867331415 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095646 3797538 504 I249T Transcriptional coactivator YAP1 Homo sapiens -0.362650933133962 0.0612890731288361 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3850784 3797539 504 I249V Transcriptional coactivator YAP1 Homo sapiens -0.0936486444969714 0.100240020782403 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095647 3797539 504 I249V Transcriptional coactivator YAP1 Homo sapiens -0.0796859878591279 0.0439676132917552 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3850785 3797540 504 I249W Transcriptional coactivator YAP1 Homo sapiens 0.30949687989727 0.0533975702630119 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095648 3797540 504 I249W Transcriptional coactivator YAP1 Homo sapiens -0.630212509401527 0.0479523503143293 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3850786 3797541 504 I249Y Transcriptional coactivator YAP1 Homo sapiens 0.0906385975886807 0.136701847537722 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095649 3797541 504 I249Y Transcriptional coactivator YAP1 Homo sapiens -0.556096591747301 0.0806439193077346 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095170 4906055 503 249I Transcriptional coactivator YAP1 Homo sapiens -1.26523817277811 0.103072994197354 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3852079 3798830 504 N250A Transcriptional coactivator YAP1 Homo sapiens 0.879546570061715 0.119704427398849 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095179 3798830 504 N250A Transcriptional coactivator YAP1 Homo sapiens -0.655912268915698 0.0505777938305626 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3852080 3798831 504 N250C Transcriptional coactivator YAP1 Homo sapiens 0.224275878371721 0.0932724181720515 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095180 3798831 504 N250C Transcriptional coactivator YAP1 Homo sapiens -0.0407878760586613 0.0669189871947306 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3852081 3798832 504 N250D Transcriptional coactivator YAP1 Homo sapiens 0.273067742544174 0.0656073433131066 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095181 3798832 504 N250D Transcriptional coactivator YAP1 Homo sapiens -2.40298444621037E-4 0.0824775874058439 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3852082 3798833 504 N250E Transcriptional coactivator YAP1 Homo sapiens 0.497676906532078 0.0910729964209077 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095182 3798833 504 N250E Transcriptional coactivator YAP1 Homo sapiens -0.710442033245823 0.0534530363325718 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3852083 3798834 504 N250F Transcriptional coactivator YAP1 Homo sapiens 1.09198410238639 0.209626930154756 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095183 3798834 504 N250F Transcriptional coactivator YAP1 Homo sapiens -0.57904827596946 0.0918501020052973 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3852084 3798835 504 N250G Transcriptional coactivator YAP1 Homo sapiens 0.912802663607662 0.153737921066142 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095184 3798835 504 N250G Transcriptional coactivator YAP1 Homo sapiens -0.624848682100089 0.0428212226159682 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3852085 3798836 504 N250H Transcriptional coactivator YAP1 Homo sapiens 0.230078860544078 0.176159171322821 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095185 3798836 504 N250H Transcriptional coactivator YAP1 Homo sapiens 0.0595804875323638 0.105897296611864 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3852086 3798837 504 N250I Transcriptional coactivator YAP1 Homo sapiens 1.66202148198077 0.776185268381016 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095186 3798837 504 N250I Transcriptional coactivator YAP1 Homo sapiens -0.957775095479543 0.175588221848123 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3852087 3798838 504 N250K Transcriptional coactivator YAP1 Homo sapiens 0.847987129634333 0.0980918938233722 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095187 3798838 504 N250K Transcriptional coactivator YAP1 Homo sapiens -0.781505762808256 0.0717513889160584 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3852088 3798839 504 N250L Transcriptional coactivator YAP1 Homo sapiens 1.2560524146894 0.329312992973768 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095188 3798839 504 N250L Transcriptional coactivator YAP1 Homo sapiens -0.657867677616546 0.0507880629265081 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3852089 3798840 504 N250M Transcriptional coactivator YAP1 Homo sapiens 0.900614749133752 0.125662439483224 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095189 3798840 504 N250M Transcriptional coactivator YAP1 Homo sapiens -0.598376307388147 0.0665940591389511 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3852090 3798841 504 N250P Transcriptional coactivator YAP1 Homo sapiens 1.07182333835937 0.207176946667462 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095630 3798841 504 N250P Transcriptional coactivator YAP1 Homo sapiens -1.09423437579613 0.0787447340774063 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3852091 3798842 504 N250Q Transcriptional coactivator YAP1 Homo sapiens 0.487953300367847 0.0954278437012305 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095631 3798842 504 N250Q Transcriptional coactivator YAP1 Homo sapiens -0.424918466518925 0.0531642087418004 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3852092 3798843 504 N250R Transcriptional coactivator YAP1 Homo sapiens 0.78826835171169 0.0890755265333779 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095632 3798843 504 N250R Transcriptional coactivator YAP1 Homo sapiens -0.837960381335012 0.0445249385883309 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3852093 3798844 504 N250S Transcriptional coactivator YAP1 Homo sapiens 0.352674955329229 0.0605605823554103 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095633 3798844 504 N250S Transcriptional coactivator YAP1 Homo sapiens -0.039398600945058 0.048798081485863 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3852094 3798845 504 N250T Transcriptional coactivator YAP1 Homo sapiens 0.927458656081353 0.139222689946115 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095634 3798845 504 N250T Transcriptional coactivator YAP1 Homo sapiens -0.851688902010881 0.068128364707856 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3852095 3798846 504 N250V Transcriptional coactivator YAP1 Homo sapiens 1.43615391666739 0.143639067571137 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095635 3798846 504 N250V Transcriptional coactivator YAP1 Homo sapiens -1.1012159208716 0.0550909805518472 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3852096 3798847 504 N250W Transcriptional coactivator YAP1 Homo sapiens 1.00587518692909 0.170015037822696 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095636 3798847 504 N250W Transcriptional coactivator YAP1 Homo sapiens -0.397051008154818 0.0468677529405597 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3852097 3798848 504 N250Y Transcriptional coactivator YAP1 Homo sapiens 0.776290144535477 0.204409937869048 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095637 3798848 504 N250Y Transcriptional coactivator YAP1 Homo sapiens -0.395290145711288 0.0865277301640069 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095178 4906056 503 250N Transcriptional coactivator YAP1 Homo sapiens -1.30696199536476 0.0944297296790099 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3853390 3800140 504 H251A Transcriptional coactivator YAP1 Homo sapiens 0.0985085177228109 0.0500016983860507 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095191 3800140 504 H251A Transcriptional coactivator YAP1 Homo sapiens -0.0523691471230927 0.0481596912702873 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3853391 3800141 504 H251C Transcriptional coactivator YAP1 Homo sapiens 0.130862327503398 0.0634017786550185 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095192 3800141 504 H251C Transcriptional coactivator YAP1 Homo sapiens -0.237495227997134 0.0540941398517772 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3853392 3800142 504 H251D Transcriptional coactivator YAP1 Homo sapiens 0.282841817544537 0.0697914123790326 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095193 3800142 504 H251D Transcriptional coactivator YAP1 Homo sapiens -0.0451959998440924 0.0620400137251788 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3853393 3800143 504 H251E Transcriptional coactivator YAP1 Homo sapiens 0.144639588335257 0.12833105374359 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095194 3800143 504 H251E Transcriptional coactivator YAP1 Homo sapiens 0.0647946455045535 0.0505444066691842 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3853394 3800144 504 H251F Transcriptional coactivator YAP1 Homo sapiens 0.330813959791252 0.0887979873194692 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095195 3800144 504 H251F Transcriptional coactivator YAP1 Homo sapiens -0.0560516014333771 0.0709280007257331 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3853395 3800145 504 H251G Transcriptional coactivator YAP1 Homo sapiens 0.198240676852516 0.0689905535324498 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095196 3800145 504 H251G Transcriptional coactivator YAP1 Homo sapiens -0.233846192675836 0.0425905042815235 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3853396 3800146 504 H251I Transcriptional coactivator YAP1 Homo sapiens 0.0529326436926478 0.0711045856137548 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095617 3800146 504 H251I Transcriptional coactivator YAP1 Homo sapiens -0.141886683266117 0.091512490647507 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3853397 3800147 504 H251K Transcriptional coactivator YAP1 Homo sapiens -0.0754788844950006 0.0710230320255744 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095618 3800147 504 H251K Transcriptional coactivator YAP1 Homo sapiens 0.0972850640118654 0.0677744257868749 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3853398 3800148 504 H251L Transcriptional coactivator YAP1 Homo sapiens 0.0922367616456254 0.0700112697079877 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095619 3800148 504 H251L Transcriptional coactivator YAP1 Homo sapiens -0.0601374706821476 0.0457211553853171 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3853399 3800149 504 H251M Transcriptional coactivator YAP1 Homo sapiens 0.0331002241745806 0.0795426329298562 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095620 3800149 504 H251M Transcriptional coactivator YAP1 Homo sapiens -0.0798252336465738 0.0594095573605974 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3853400 3800150 504 H251N Transcriptional coactivator YAP1 Homo sapiens 0.020378234635761 0.140367764259614 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095621 3800150 504 H251N Transcriptional coactivator YAP1 Homo sapiens -0.355663181674818 0.121048590959345 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3853401 3800151 504 H251P Transcriptional coactivator YAP1 Homo sapiens 0.233436697935837 0.0491128077107163 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095622 3800151 504 H251P Transcriptional coactivator YAP1 Homo sapiens -0.0906219541600241 0.0549083855615438 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3853402 3800152 504 H251Q Transcriptional coactivator YAP1 Homo sapiens 0.0991280747305706 0.0833244423035505 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095623 3800152 504 H251Q Transcriptional coactivator YAP1 Homo sapiens -0.0224615390503491 0.0609029564956017 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3853403 3800153 504 H251R Transcriptional coactivator YAP1 Homo sapiens 0.0354710981832171 0.106418941207839 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095624 3800153 504 H251R Transcriptional coactivator YAP1 Homo sapiens 0.0180939954658309 0.0433672729822119 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3853404 3800154 504 H251S Transcriptional coactivator YAP1 Homo sapiens 0.0488266038359777 0.0712682644326743 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095625 3800154 504 H251S Transcriptional coactivator YAP1 Homo sapiens -0.120824763302153 0.0477119325161762 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3853405 3800155 504 H251T Transcriptional coactivator YAP1 Homo sapiens 0.0110468214032705 0.0794874649218239 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095626 3800155 504 H251T Transcriptional coactivator YAP1 Homo sapiens -0.191314163668138 0.0604763312735738 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3853406 3800156 504 H251V Transcriptional coactivator YAP1 Homo sapiens 0.0959825372830734 0.0633975284700894 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095627 3800156 504 H251V Transcriptional coactivator YAP1 Homo sapiens -0.166296867650495 0.04618836876516 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3853407 3800157 504 H251W Transcriptional coactivator YAP1 Homo sapiens 0.272262604255365 0.0749239478525422 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095628 3800157 504 H251W Transcriptional coactivator YAP1 Homo sapiens -0.188530043609433 0.050274325539854 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3853408 3800158 504 H251Y Transcriptional coactivator YAP1 Homo sapiens 0.245250501612407 0.0771506351532847 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095629 3800158 504 H251Y Transcriptional coactivator YAP1 Homo sapiens 0.0227973203206475 0.0964313679812897 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095190 4906057 503 251H Transcriptional coactivator YAP1 Homo sapiens -1.19567563215787 0.0962965780590421 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3854701 3801449 504 K252A Transcriptional coactivator YAP1 Homo sapiens -0.0349454976067115 0.101075215316765 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095198 3801449 504 K252A Transcriptional coactivator YAP1 Homo sapiens -0.0209903078447063 0.0482872006270771 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3854702 3801450 504 K252C Transcriptional coactivator YAP1 Homo sapiens 0.104648836521609 0.0785193814970651 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095199 3801450 504 K252C Transcriptional coactivator YAP1 Homo sapiens -0.00395935450474812 0.0678304980762538 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3854703 3801451 504 K252D Transcriptional coactivator YAP1 Homo sapiens 0.0331972976331723 0.0812631982617511 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095200 3801451 504 K252D Transcriptional coactivator YAP1 Homo sapiens -0.146282076008125 0.0613575024872381 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3854704 3801452 504 K252E Transcriptional coactivator YAP1 Homo sapiens -0.00961154846880623 0.070363865139735 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095201 3801452 504 K252E Transcriptional coactivator YAP1 Homo sapiens -0.0320408535364151 0.050584931171782 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3854705 3801453 504 K252F Transcriptional coactivator YAP1 Homo sapiens 0.145969940104035 0.0578310679074968 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095202 3801453 504 K252F Transcriptional coactivator YAP1 Homo sapiens -0.230521003271627 0.0727374798413376 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3854706 3801454 504 K252G Transcriptional coactivator YAP1 Homo sapiens 0.0123873625881285 0.0910380159473285 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095203 3801454 504 K252G Transcriptional coactivator YAP1 Homo sapiens -0.0291509066792515 0.0438537977635479 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3854707 3801455 504 K252H Transcriptional coactivator YAP1 Homo sapiens -0.0233372208103089 0.104335805956717 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095204 3801455 504 K252H Transcriptional coactivator YAP1 Homo sapiens -0.019320154085569 0.0623094901299463 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3854708 3801456 504 K252I Transcriptional coactivator YAP1 Homo sapiens 0.0281340344350771 0.0816822685212735 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095205 3801456 504 K252I Transcriptional coactivator YAP1 Homo sapiens -0.253369247765969 0.0852312325293532 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3854709 3801457 504 K252L Transcriptional coactivator YAP1 Homo sapiens 0.0233635163680068 0.0780870531811923 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095606 3801457 504 K252L Transcriptional coactivator YAP1 Homo sapiens -0.0428638318269267 0.0486907587898018 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3854710 3801458 504 K252M Transcriptional coactivator YAP1 Homo sapiens 0.0678052166781073 0.0394263144268536 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095607 3801458 504 K252M Transcriptional coactivator YAP1 Homo sapiens -0.0777397295957409 0.0593254608618822 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3854711 3801459 504 K252N Transcriptional coactivator YAP1 Homo sapiens -0.0198898302103896 0.148790591029951 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095608 3801459 504 K252N Transcriptional coactivator YAP1 Homo sapiens -0.0613015654651955 0.080983360753017 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3854712 3801460 504 K252P Transcriptional coactivator YAP1 Homo sapiens 0.245267774670035 0.0681469835343785 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095609 3801460 504 K252P Transcriptional coactivator YAP1 Homo sapiens -0.177075287289024 0.0573341506185797 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3854713 3801461 504 K252Q Transcriptional coactivator YAP1 Homo sapiens 0.0176824122151085 0.065791883709575 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095610 3801461 504 K252Q Transcriptional coactivator YAP1 Homo sapiens 0.040387643881031 0.0608719166203545 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3854714 3801462 504 K252R Transcriptional coactivator YAP1 Homo sapiens -0.0422045107652638 0.0831083276579617 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095611 3801462 504 K252R Transcriptional coactivator YAP1 Homo sapiens -0.0217748583956873 0.0453362084166973 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3854715 3801463 504 K252S Transcriptional coactivator YAP1 Homo sapiens -0.00972883309274421 0.0951267748694057 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095612 3801463 504 K252S Transcriptional coactivator YAP1 Homo sapiens -0.056704863099052 0.0528968807006106 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3854716 3801464 504 K252T Transcriptional coactivator YAP1 Homo sapiens -0.0633910097194156 0.0943997918212835 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095613 3801464 504 K252T Transcriptional coactivator YAP1 Homo sapiens -0.0942662153400376 0.060990928005659 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3854717 3801465 504 K252V Transcriptional coactivator YAP1 Homo sapiens -0.0202073731505976 0.0750428832631604 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095614 3801465 504 K252V Transcriptional coactivator YAP1 Homo sapiens -0.0799963070425789 0.0457045732012578 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3854718 3801466 504 K252W Transcriptional coactivator YAP1 Homo sapiens 0.19391373653175 0.0833442922538155 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095615 3801466 504 K252W Transcriptional coactivator YAP1 Homo sapiens -0.203591663669799 0.0550735708499654 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3854719 3801467 504 K252Y Transcriptional coactivator YAP1 Homo sapiens 0.159399781795033 0.0813283137505284 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095616 3801467 504 K252Y Transcriptional coactivator YAP1 Homo sapiens -0.219952645849589 0.0968828426087001 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095197 4906058 503 252K Transcriptional coactivator YAP1 Homo sapiens -1.2398547319516 0.0985362073043224 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3856012 3802758 504 N253A Transcriptional coactivator YAP1 Homo sapiens 0.00658546428607188 0.102059667073528 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095207 3802758 504 N253A Transcriptional coactivator YAP1 Homo sapiens 0.0835785043859022 0.0473810049561833 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3856013 3802759 504 N253C Transcriptional coactivator YAP1 Homo sapiens 0.0300462226797083 0.0668404201980608 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095208 3802759 504 N253C Transcriptional coactivator YAP1 Homo sapiens 0.066141749036816 0.0517126708689534 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3856014 3802760 504 N253D Transcriptional coactivator YAP1 Homo sapiens 0.152615082297838 0.06397378130347 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095209 3802760 504 N253D Transcriptional coactivator YAP1 Homo sapiens -0.0110823733002679 0.0646886913956602 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3856015 3802761 504 N253E Transcriptional coactivator YAP1 Homo sapiens 0.15441064758354 0.0584678405835731 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095210 3802761 504 N253E Transcriptional coactivator YAP1 Homo sapiens -0.0799461785590982 0.0504711554280855 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3856016 3802762 504 N253F Transcriptional coactivator YAP1 Homo sapiens 0.150083054600009 0.0948721171117718 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095211 3802762 504 N253F Transcriptional coactivator YAP1 Homo sapiens 0.316488965370102 0.0721401790684117 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3856017 3802763 504 N253G Transcriptional coactivator YAP1 Homo sapiens 0.0801742304403277 0.0964808408021228 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095212 3802763 504 N253G Transcriptional coactivator YAP1 Homo sapiens 0.0707822143647284 0.04214705021147 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3856018 3802764 504 N253H Transcriptional coactivator YAP1 Homo sapiens 0.0205372412895161 0.0845601354659631 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095213 3802764 504 N253H Transcriptional coactivator YAP1 Homo sapiens -0.146286850149408 0.079690602862369 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3856019 3802765 504 N253I Transcriptional coactivator YAP1 Homo sapiens 0.293412309908847 0.124030399978276 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095214 3802765 504 N253I Transcriptional coactivator YAP1 Homo sapiens 0.0848476302771952 0.0845642054229765 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3856020 3802766 504 N253K Transcriptional coactivator YAP1 Homo sapiens 0.00695928341067391 0.132191812806093 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095215 3802766 504 N253K Transcriptional coactivator YAP1 Homo sapiens -0.0409875943023695 0.0756469608932542 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3856021 3802767 504 N253L Transcriptional coactivator YAP1 Homo sapiens 3.25770924637713E-4 0.111453999247012 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095216 3802767 504 N253L Transcriptional coactivator YAP1 Homo sapiens 0.221379318403249 0.0483555185888491 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3856022 3802768 504 N253M Transcriptional coactivator YAP1 Homo sapiens 0.0963281334693191 0.116557737663989 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095217 3802768 504 N253M Transcriptional coactivator YAP1 Homo sapiens 0.182096888229431 0.0718859640019483 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3856023 3802769 504 N253P Transcriptional coactivator YAP1 Homo sapiens 0.887752116395733 0.116044193344124 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095598 3802769 504 N253P Transcriptional coactivator YAP1 Homo sapiens -0.839435193146618 0.0541717355614442 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3856024 3802770 504 N253Q Transcriptional coactivator YAP1 Homo sapiens 0.0722971197629892 0.0837236356060729 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095599 3802770 504 N253Q Transcriptional coactivator YAP1 Homo sapiens -0.0268258998740116 0.0585612163251618 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3856025 3802771 504 N253R Transcriptional coactivator YAP1 Homo sapiens 0.0856643620926922 0.0913354906328298 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095600 3802771 504 N253R Transcriptional coactivator YAP1 Homo sapiens 0.0248128036326504 0.0432242556231517 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3856026 3802772 504 N253S Transcriptional coactivator YAP1 Homo sapiens -0.0573370652110048 0.085534966073363 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095601 3802772 504 N253S Transcriptional coactivator YAP1 Homo sapiens -0.0762987346182289 0.0492544416511872 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3856027 3802773 504 N253T Transcriptional coactivator YAP1 Homo sapiens -0.180886486490769 0.143657758482356 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095602 3802773 504 N253T Transcriptional coactivator YAP1 Homo sapiens -0.1047733046156 0.0551766366033818 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3856028 3802774 504 N253V Transcriptional coactivator YAP1 Homo sapiens 0.287077430089595 0.059713383327316 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095603 3802774 504 N253V Transcriptional coactivator YAP1 Homo sapiens -0.0147425482845608 0.045326397556359 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3856029 3802775 504 N253W Transcriptional coactivator YAP1 Homo sapiens 0.30247689547372 0.156760514853426 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095604 3802775 504 N253W Transcriptional coactivator YAP1 Homo sapiens 0.154509512820644 0.0486464945431983 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3856030 3802776 504 N253Y Transcriptional coactivator YAP1 Homo sapiens 0.12778479751589 0.0744607868474824 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095605 3802776 504 N253Y Transcriptional coactivator YAP1 Homo sapiens 0.296256950299315 0.0538552099943242 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095206 4906059 503 253N Transcriptional coactivator YAP1 Homo sapiens -1.21850344730597 0.0943493649673982 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3857323 3804064 504 K254A Transcriptional coactivator YAP1 Homo sapiens 0.0271683028468292 0.0664662418838825 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095219 3804064 504 K254A Transcriptional coactivator YAP1 Homo sapiens -0.0141823823739212 0.0499967728794147 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3857324 3804065 504 K254C Transcriptional coactivator YAP1 Homo sapiens 0.0303464025398376 0.0915702680576218 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095220 3804065 504 K254C Transcriptional coactivator YAP1 Homo sapiens 0.00117046030475986 0.0633608753941844 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3857325 3804066 504 K254D Transcriptional coactivator YAP1 Homo sapiens 0.180496396708521 0.133881459927473 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095221 3804066 504 K254D Transcriptional coactivator YAP1 Homo sapiens -0.53474679106392 0.0781159478427133 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3857326 3804067 504 K254E Transcriptional coactivator YAP1 Homo sapiens 0.0364207236298469 0.10079795179661 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095222 3804067 504 K254E Transcriptional coactivator YAP1 Homo sapiens -0.182456540206149 0.0534964889751571 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3857327 3804068 504 K254F Transcriptional coactivator YAP1 Homo sapiens 0.322208128632503 0.0698724550898082 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095223 3804068 504 K254F Transcriptional coactivator YAP1 Homo sapiens -0.358386829277261 0.0794907493513245 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3857328 3804069 504 K254G Transcriptional coactivator YAP1 Homo sapiens -0.0715572545022461 0.101803755753276 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095224 3804069 504 K254G Transcriptional coactivator YAP1 Homo sapiens 0.0405666741791758 0.0425132745893549 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3857329 3804070 504 K254H Transcriptional coactivator YAP1 Homo sapiens -0.0490634765332977 0.104186953835342 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095225 3804070 504 K254H Transcriptional coactivator YAP1 Homo sapiens 0.00193193583953563 0.0865684695029625 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3857330 3804071 504 K254I Transcriptional coactivator YAP1 Homo sapiens 0.587251663815742 0.108065138993639 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095226 3804071 504 K254I Transcriptional coactivator YAP1 Homo sapiens -0.752261044252777 0.133025797474251 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3857331 3804072 504 K254L Transcriptional coactivator YAP1 Homo sapiens 0.147878157233333 0.0549985689018567 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095587 3804072 504 K254L Transcriptional coactivator YAP1 Homo sapiens -0.317748542978827 0.0511882394058234 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3857332 3804073 504 K254M Transcriptional coactivator YAP1 Homo sapiens -0.00768194346821036 0.0674805023244618 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095588 3804073 504 K254M Transcriptional coactivator YAP1 Homo sapiens -0.131418582811039 0.0534500604511716 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3857333 3804074 504 K254N Transcriptional coactivator YAP1 Homo sapiens -0.139113936074613 0.15867559619455 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095589 3804074 504 K254N Transcriptional coactivator YAP1 Homo sapiens 0.0847935233426448 0.0824702670558753 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3857334 3804075 504 K254P Transcriptional coactivator YAP1 Homo sapiens 0.654758205133919 0.0778091943875854 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095590 3804075 504 K254P Transcriptional coactivator YAP1 Homo sapiens -0.600125393616511 0.0684961725092667 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3857335 3804076 504 K254Q Transcriptional coactivator YAP1 Homo sapiens -0.123414106284335 0.0924365777266089 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095591 3804076 504 K254Q Transcriptional coactivator YAP1 Homo sapiens 0.0599902679925619 0.0588218287409456 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3857336 3804077 504 K254R Transcriptional coactivator YAP1 Homo sapiens -0.195533217904897 0.0946899904422489 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095592 3804077 504 K254R Transcriptional coactivator YAP1 Homo sapiens 0.0523619859111669 0.0437897128737143 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3857337 3804078 504 K254S Transcriptional coactivator YAP1 Homo sapiens -0.00895924354423185 0.086469477875888 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095593 3804078 504 K254S Transcriptional coactivator YAP1 Homo sapiens -0.0346992545413114 0.0518289371230196 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3857338 3804079 504 K254T Transcriptional coactivator YAP1 Homo sapiens 0.245023701301981 0.110195586668735 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095594 3804079 504 K254T Transcriptional coactivator YAP1 Homo sapiens -0.25107845563993 0.0799196025059515 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3857339 3804080 504 K254V Transcriptional coactivator YAP1 Homo sapiens 0.493713926977394 0.0400994145374199 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095595 3804080 504 K254V Transcriptional coactivator YAP1 Homo sapiens -0.536901361025326 0.0485986894751426 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3857340 3804081 504 K254W Transcriptional coactivator YAP1 Homo sapiens 0.425794452680236 0.0558015747838763 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095596 3804081 504 K254W Transcriptional coactivator YAP1 Homo sapiens -0.34808821083776 0.0485084104634648 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3857341 3804082 504 K254Y Transcriptional coactivator YAP1 Homo sapiens 0.226468172595372 0.0284968597930068 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095597 3804082 504 K254Y Transcriptional coactivator YAP1 Homo sapiens -0.365216238383823 0.0979278225667158 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095218 4906060 503 254K Transcriptional coactivator YAP1 Homo sapiens -1.00287831784469 0.0760217628116459 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3858634 3805373 504 T255A Transcriptional coactivator YAP1 Homo sapiens 0.0350811378082415 0.0757955564680031 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095228 3805373 504 T255A Transcriptional coactivator YAP1 Homo sapiens 0.011632195238126 0.0910955489753831 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3858635 3805374 504 T255C Transcriptional coactivator YAP1 Homo sapiens -0.0998701185346082 0.0812474443329694 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095229 3805374 504 T255C Transcriptional coactivator YAP1 Homo sapiens 0.284931891483784 0.175543185782012 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3858636 3805375 504 T255D Transcriptional coactivator YAP1 Homo sapiens 0.227339319845775 0.0871404151970886 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095230 3805375 504 T255D Transcriptional coactivator YAP1 Homo sapiens -0.648923244352212 0.146428164731411 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3858637 3805376 504 T255E Transcriptional coactivator YAP1 Homo sapiens 0.0681049655557564 0.0663437809690591 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095231 3805376 504 T255E Transcriptional coactivator YAP1 Homo sapiens NA NA P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3858638 3805377 504 T255F Transcriptional coactivator YAP1 Homo sapiens 0.0594997870597711 0.0769571589033552 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095232 3805377 504 T255F Transcriptional coactivator YAP1 Homo sapiens -0.428960572805927 0.169714993671697 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3858639 3805378 504 T255G Transcriptional coactivator YAP1 Homo sapiens 0.314619202323807 0.0676703034078626 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095233 3805378 504 T255G Transcriptional coactivator YAP1 Homo sapiens -0.369232086893764 0.118133420722398 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3858640 3805379 504 T255H Transcriptional coactivator YAP1 Homo sapiens 0.186138081155765 0.112144375791048 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095234 3805379 504 T255H Transcriptional coactivator YAP1 Homo sapiens -0.58767029555909 0.210370944292881 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3858641 3805380 504 T255I Transcriptional coactivator YAP1 Homo sapiens -0.179339822027011 0.163046377448555 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095235 3805380 504 T255I Transcriptional coactivator YAP1 Homo sapiens 0.253549073754328 0.0828800475160734 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3858642 3805381 504 T255K Transcriptional coactivator YAP1 Homo sapiens 0.0708294837576848 0.0926055206083028 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095236 3805381 504 T255K Transcriptional coactivator YAP1 Homo sapiens -0.830826222876497 0.370978706482464 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3858643 3805382 504 T255L Transcriptional coactivator YAP1 Homo sapiens -0.0302873309333093 0.0854318172246647 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095237 3805382 504 T255L Transcriptional coactivator YAP1 Homo sapiens 0.107917076651023 0.109237285854053 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3858644 3805383 504 T255M Transcriptional coactivator YAP1 Homo sapiens -0.0459840977097193 0.07034649080685 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095238 3805383 504 T255M Transcriptional coactivator YAP1 Homo sapiens 0.156352331356214 0.470570794700733 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3858645 3805384 504 T255N Transcriptional coactivator YAP1 Homo sapiens 0.115987805531892 0.106119229464451 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095239 3805384 504 T255N Transcriptional coactivator YAP1 Homo sapiens -0.759186095323059 0.11075999821654 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3858646 3805385 504 T255P Transcriptional coactivator YAP1 Homo sapiens 1.00055121421414 0.191016240191798 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095240 3805385 504 T255P Transcriptional coactivator YAP1 Homo sapiens -0.998002964765608 0.135451379522538 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3858647 3805386 504 T255Q Transcriptional coactivator YAP1 Homo sapiens -0.039123306736508 0.0851605176918342 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095241 3805386 504 T255Q Transcriptional coactivator YAP1 Homo sapiens 0.0900936158579436 0.326308737438831 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3858648 3805387 504 T255R Transcriptional coactivator YAP1 Homo sapiens 0.12348659011066 0.0846180536598484 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095242 3805387 504 T255R Transcriptional coactivator YAP1 Homo sapiens -0.689131857935098 0.130503698203009 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3858649 3805388 504 T255S Transcriptional coactivator YAP1 Homo sapiens -0.0439604785509731 0.102997453442679 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095243 3805388 504 T255S Transcriptional coactivator YAP1 Homo sapiens -0.220322641799088 0.0774963120454811 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3858650 3805389 504 T255V Transcriptional coactivator YAP1 Homo sapiens -0.0792827606217956 0.0984758789582171 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095584 3805389 504 T255V Transcriptional coactivator YAP1 Homo sapiens 0.375520426654822 0.0892499455240641 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3858651 3805390 504 T255W Transcriptional coactivator YAP1 Homo sapiens 0.141728869947935 0.141365032962722 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095585 3805390 504 T255W Transcriptional coactivator YAP1 Homo sapiens 0.369368945610568 0.200633128316191 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3858652 3805391 504 T255Y Transcriptional coactivator YAP1 Homo sapiens 0.111341494815178 0.155414915532149 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095586 3805391 504 T255Y Transcriptional coactivator YAP1 Homo sapiens -0.153577759580077 0.176026567587003 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095227 4906061 503 255T Transcriptional coactivator YAP1 Homo sapiens -1.0512809492511 0.525935317634342 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095244 4906061 503 255T Transcriptional coactivator YAP1 Homo sapiens -1.46317802498732 0.312608622903601 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3859945 3806683 504 T256A Transcriptional coactivator YAP1 Homo sapiens 0.220703022357703 0.0798205941240002 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095245 3806683 504 T256A Transcriptional coactivator YAP1 Homo sapiens -0.183595968592564 0.0915580041277464 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3859946 3806684 504 T256C Transcriptional coactivator YAP1 Homo sapiens 0.0083758075944951 0.0770904438925323 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095246 3806684 504 T256C Transcriptional coactivator YAP1 Homo sapiens -0.327041408987861 0.0695653016652766 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3859947 3806685 504 T256D Transcriptional coactivator YAP1 Homo sapiens 0.685487312239247 0.136502132731995 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095247 3806685 504 T256D Transcriptional coactivator YAP1 Homo sapiens -1.02644578672344 0.147603478746476 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3859948 3806686 504 T256E Transcriptional coactivator YAP1 Homo sapiens 0.236654089052508 0.0316670498884861 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095248 3806686 504 T256E Transcriptional coactivator YAP1 Homo sapiens -1.35653039250368 0.28804455203184 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3859949 3806687 504 T256F Transcriptional coactivator YAP1 Homo sapiens 0.494609931676854 0.101641641074428 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095249 3806687 504 T256F Transcriptional coactivator YAP1 Homo sapiens -0.781247561333821 0.0747806452158849 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3859950 3806688 504 T256G Transcriptional coactivator YAP1 Homo sapiens 0.484082391274086 0.0530947910046336 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095250 3806688 504 T256G Transcriptional coactivator YAP1 Homo sapiens -0.776592296167928 0.0914388097336927 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3859951 3806689 504 T256H Transcriptional coactivator YAP1 Homo sapiens 0.292468255726603 0.176194280078392 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095251 3806689 504 T256H Transcriptional coactivator YAP1 Homo sapiens -0.867442136005236 0.0742868716966995 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3859952 3806690 504 T256I Transcriptional coactivator YAP1 Homo sapiens 0.427425164354044 0.0770765691823981 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095252 3806690 504 T256I Transcriptional coactivator YAP1 Homo sapiens -0.775977784615674 0.0718608042773823 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3859953 3806691 504 T256K Transcriptional coactivator YAP1 Homo sapiens 0.304521249053304 0.0833827273389204 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095253 3806691 504 T256K Transcriptional coactivator YAP1 Homo sapiens -0.816960843483824 0.113582390974537 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3859954 3806692 504 T256L Transcriptional coactivator YAP1 Homo sapiens 0.44386397268393 0.0539083576453401 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095254 3806692 504 T256L Transcriptional coactivator YAP1 Homo sapiens -0.836195222164327 0.0672271261869953 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3859955 3806693 504 T256M Transcriptional coactivator YAP1 Homo sapiens 0.244625847083405 0.0874998185766309 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095255 3806693 504 T256M Transcriptional coactivator YAP1 Homo sapiens -0.733898503339729 0.11640629554394 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3859956 3806694 504 T256N Transcriptional coactivator YAP1 Homo sapiens 0.29427862970536 0.0703327218730948 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095256 3806694 504 T256N Transcriptional coactivator YAP1 Homo sapiens -0.695443034005297 0.0762239476950173 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3859957 3806695 504 T256P Transcriptional coactivator YAP1 Homo sapiens 0.628480089285706 0.106193115390437 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095257 3806695 504 T256P Transcriptional coactivator YAP1 Homo sapiens -1.02118675182318 0.0762129671700645 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3859958 3806696 504 T256Q Transcriptional coactivator YAP1 Homo sapiens 0.197819304268831 0.143617225874162 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095258 3806696 504 T256Q Transcriptional coactivator YAP1 Homo sapiens -0.848457604051922 0.14391012348026 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3859959 3806697 504 T256R Transcriptional coactivator YAP1 Homo sapiens 0.299703607609406 0.0434865531114328 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095259 3806697 504 T256R Transcriptional coactivator YAP1 Homo sapiens -0.808288456703649 0.0633783567081855 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3859960 3806698 504 T256S Transcriptional coactivator YAP1 Homo sapiens 0.0266357052753833 0.0783429600003225 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095260 3806698 504 T256S Transcriptional coactivator YAP1 Homo sapiens 0.0453384283923944 0.056258027345589 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3859961 3806699 504 T256V Transcriptional coactivator YAP1 Homo sapiens 0.182296361841476 0.0831007027564314 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095581 3806699 504 T256V Transcriptional coactivator YAP1 Homo sapiens -0.781646679545151 0.0932312610787181 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3859962 3806700 504 T256W Transcriptional coactivator YAP1 Homo sapiens 0.462727490698222 0.0934849499241231 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095582 3806700 504 T256W Transcriptional coactivator YAP1 Homo sapiens -0.876449349227452 0.143416875116616 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3859963 3806701 504 T256Y Transcriptional coactivator YAP1 Homo sapiens 0.432900070959521 0.0860641292883345 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095583 3806701 504 T256Y Transcriptional coactivator YAP1 Homo sapiens -0.79745879461534 0.0716236885936173 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3861256 3807992 504 S257A Transcriptional coactivator YAP1 Homo sapiens 0.293911338108621 0.0728125545543081 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095262 3807992 504 S257A Transcriptional coactivator YAP1 Homo sapiens -0.161992183592881 0.0771949682476438 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3861257 3807993 504 S257C Transcriptional coactivator YAP1 Homo sapiens 0.21833183101993 0.074125396956526 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095263 3807993 504 S257C Transcriptional coactivator YAP1 Homo sapiens -0.306047918382299 0.076059629708929 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3861258 3807994 504 S257D Transcriptional coactivator YAP1 Homo sapiens 0.667382447171051 0.0888226309652063 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095264 3807994 504 S257D Transcriptional coactivator YAP1 Homo sapiens -0.753356709677423 0.112645545316601 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3861259 3807995 504 S257E Transcriptional coactivator YAP1 Homo sapiens 0.581618734051777 0.0795555849098761 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095265 3807995 504 S257E Transcriptional coactivator YAP1 Homo sapiens -0.556002143318902 0.314554722028946 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3861260 3807996 504 S257F Transcriptional coactivator YAP1 Homo sapiens 0.676405847464966 0.10485015372695 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095266 3807996 504 S257F Transcriptional coactivator YAP1 Homo sapiens -1.02708194104952 0.0851472872117787 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3861261 3807997 504 S257G Transcriptional coactivator YAP1 Homo sapiens 0.52888236743254 0.0756115280742201 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095267 3807997 504 S257G Transcriptional coactivator YAP1 Homo sapiens -0.57945590806608 0.115879548622288 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3861262 3807998 504 S257H Transcriptional coactivator YAP1 Homo sapiens 0.247854468500736 0.0760927183254901 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095268 3807998 504 S257H Transcriptional coactivator YAP1 Homo sapiens -0.503142214471828 0.0778674537888884 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3861263 3807999 504 S257I Transcriptional coactivator YAP1 Homo sapiens 0.827935168991167 0.113901152653529 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095269 3807999 504 S257I Transcriptional coactivator YAP1 Homo sapiens -0.74035210795823 0.0742999687576216 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3861264 3808000 504 S257K Transcriptional coactivator YAP1 Homo sapiens 0.566251451693592 0.169499411733671 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095270 3808000 504 S257K Transcriptional coactivator YAP1 Homo sapiens -0.859199342371586 0.181855077973404 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3861265 3808001 504 S257L Transcriptional coactivator YAP1 Homo sapiens 0.640262880228189 0.0656813451429975 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095271 3808001 504 S257L Transcriptional coactivator YAP1 Homo sapiens -1.13745976925628 0.079338374675348 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3861266 3808002 504 S257M Transcriptional coactivator YAP1 Homo sapiens 0.349884900783568 0.0943297881134613 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095272 3808002 504 S257M Transcriptional coactivator YAP1 Homo sapiens -0.363203142142462 0.0984189225667822 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3861267 3808003 504 S257N Transcriptional coactivator YAP1 Homo sapiens 0.49290228456656 0.0971097376390888 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095273 3808003 504 S257N Transcriptional coactivator YAP1 Homo sapiens -0.692968676146894 0.0896132576757659 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3861268 3808004 504 S257P Transcriptional coactivator YAP1 Homo sapiens 0.887657446536561 0.0504454145418715 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095274 3808004 504 S257P Transcriptional coactivator YAP1 Homo sapiens -0.808043861531872 0.0889270544352324 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3861269 3808005 504 S257Q Transcriptional coactivator YAP1 Homo sapiens 0.163244573125435 0.0616765332809949 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095275 3808005 504 S257Q Transcriptional coactivator YAP1 Homo sapiens -0.409803535214223 0.112912817659475 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3861270 3808006 504 S257R Transcriptional coactivator YAP1 Homo sapiens 0.540845687146055 0.114670338226296 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095276 3808006 504 S257R Transcriptional coactivator YAP1 Homo sapiens -0.851583393488508 0.0693896291798348 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3861271 3808007 504 S257T Transcriptional coactivator YAP1 Homo sapiens -0.136531063696922 0.144724817089966 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095577 3808007 504 S257T Transcriptional coactivator YAP1 Homo sapiens 0.149181571147856 0.0579216962294823 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3861272 3808008 504 S257V Transcriptional coactivator YAP1 Homo sapiens 0.324376454378793 0.110814958005191 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095578 3808008 504 S257V Transcriptional coactivator YAP1 Homo sapiens -0.794928499734894 0.0724388970885429 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3861273 3808009 504 S257W Transcriptional coactivator YAP1 Homo sapiens 0.65309066302518 0.0757165212578665 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095579 3808009 504 S257W Transcriptional coactivator YAP1 Homo sapiens -0.639216937707995 0.110200707565136 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3861274 3808010 504 S257Y Transcriptional coactivator YAP1 Homo sapiens 0.609169272222076 0.106372721431355 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095580 3808010 504 S257Y Transcriptional coactivator YAP1 Homo sapiens -0.700631650321618 0.0993503575312634 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095261 4906062 503 257S Transcriptional coactivator YAP1 Homo sapiens -1.25053037228519 0.176901190270206 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3862567 3809302 504 W258A Transcriptional coactivator YAP1 Homo sapiens 0.1877012084751 0.0518158454307509 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095278 3809302 504 W258A Transcriptional coactivator YAP1 Homo sapiens -0.412184240334442 0.110487951732381 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3862568 3809303 504 W258C Transcriptional coactivator YAP1 Homo sapiens 0.184983115625553 0.0775017744719003 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095279 3809303 504 W258C Transcriptional coactivator YAP1 Homo sapiens -0.679061920863094 0.0858463806337786 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3862569 3809304 504 W258D Transcriptional coactivator YAP1 Homo sapiens 0.196617572075749 0.0498457007326929 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095280 3809304 504 W258D Transcriptional coactivator YAP1 Homo sapiens -0.630616003909035 0.107844191427422 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3862570 3809305 504 W258E Transcriptional coactivator YAP1 Homo sapiens 0.085326254649021 0.0692280721408498 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095281 3809305 504 W258E Transcriptional coactivator YAP1 Homo sapiens -0.961586690311556 0.200570984910479 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3862571 3809306 504 W258F Transcriptional coactivator YAP1 Homo sapiens -0.0970713093056677 0.100966378174496 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095282 3809306 504 W258F Transcriptional coactivator YAP1 Homo sapiens 0.00564940051923494 0.0727065991041332 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3862572 3809307 504 W258G Transcriptional coactivator YAP1 Homo sapiens 0.25982578895951 0.0578904557178814 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095283 3809307 504 W258G Transcriptional coactivator YAP1 Homo sapiens -0.702527382256418 0.0938951849932603 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3862573 3809308 504 W258H Transcriptional coactivator YAP1 Homo sapiens 0.149513662602613 0.0908334736877105 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095284 3809308 504 W258H Transcriptional coactivator YAP1 Homo sapiens -0.383182923415418 0.0691381512877074 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3862574 3809309 504 W258I Transcriptional coactivator YAP1 Homo sapiens 0.234810688087341 0.0886202942556177 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095285 3809309 504 W258I Transcriptional coactivator YAP1 Homo sapiens -0.477438794782674 0.0777765302681373 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3862575 3809310 504 W258K Transcriptional coactivator YAP1 Homo sapiens 0.168016314372548 0.0864579595033873 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095286 3809310 504 W258K Transcriptional coactivator YAP1 Homo sapiens -0.6134144545872 0.113203960708769 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3862576 3809311 504 W258L Transcriptional coactivator YAP1 Homo sapiens 0.126212436143728 0.0518519388068704 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095287 3809311 504 W258L Transcriptional coactivator YAP1 Homo sapiens -0.433788502748252 0.0566248325773302 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3862577 3809312 504 W258M Transcriptional coactivator YAP1 Homo sapiens 0.0851559377996812 0.0727188749420883 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095288 3809312 504 W258M Transcriptional coactivator YAP1 Homo sapiens -0.319232505227894 0.104637400727053 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3862578 3809313 504 W258N Transcriptional coactivator YAP1 Homo sapiens 0.228550515648932 0.0890339474142004 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095289 3809313 504 W258N Transcriptional coactivator YAP1 Homo sapiens -0.267351911896183 0.0737149454846973 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3862579 3809314 504 W258P Transcriptional coactivator YAP1 Homo sapiens 0.257633877331273 0.104949500252408 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095290 3809314 504 W258P Transcriptional coactivator YAP1 Homo sapiens -0.544600379966744 0.0723533365198339 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3862580 3809315 504 W258Q Transcriptional coactivator YAP1 Homo sapiens 0.128469373238293 0.0812304807275134 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095291 3809315 504 W258Q Transcriptional coactivator YAP1 Homo sapiens -0.724206757826428 0.427566364412997 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3862581 3809316 504 W258R Transcriptional coactivator YAP1 Homo sapiens 0.18027556038542 0.058397196591074 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095292 3809316 504 W258R Transcriptional coactivator YAP1 Homo sapiens -0.370687404295127 0.075639258611983 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3862582 3809317 504 W258S Transcriptional coactivator YAP1 Homo sapiens 0.114547615121086 0.0706404028538854 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095293 3809317 504 W258S Transcriptional coactivator YAP1 Homo sapiens -0.414476623840909 0.0660555678297402 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3862583 3809318 504 W258T Transcriptional coactivator YAP1 Homo sapiens -6.1026916651839E-4 0.0941866692968826 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095294 3809318 504 W258T Transcriptional coactivator YAP1 Homo sapiens -0.404624387611449 0.0817908271821606 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3862584 3809319 504 W258V Transcriptional coactivator YAP1 Homo sapiens 0.185752706299346 0.103798822041386 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095295 3809319 504 W258V Transcriptional coactivator YAP1 Homo sapiens -0.448889429905188 0.0804548633128937 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3862585 3809320 504 W258Y Transcriptional coactivator YAP1 Homo sapiens -0.146254050956807 0.100057365230985 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095576 3809320 504 W258Y Transcriptional coactivator YAP1 Homo sapiens -0.15709391463564 0.0743619371114861 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095277 4906063 503 258W Transcriptional coactivator YAP1 Homo sapiens -0.994008202046338 0.128497285759445 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 9.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3863878 3810611 504 L259A Transcriptional coactivator YAP1 Homo sapiens -0.0247973872028095 0.0897852567789229 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095297 3810611 504 L259A Transcriptional coactivator YAP1 Homo sapiens -0.0963843426896436 0.066138558319058 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3863879 3810612 504 L259C Transcriptional coactivator YAP1 Homo sapiens -0.0721147342789221 0.0909096326805638 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095298 3810612 504 L259C Transcriptional coactivator YAP1 Homo sapiens -0.0505064363321732 0.0598193776053061 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3863880 3810613 504 L259D Transcriptional coactivator YAP1 Homo sapiens 0.0104234868284451 0.0620251272148316 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095299 3810613 504 L259D Transcriptional coactivator YAP1 Homo sapiens -0.312984745667748 0.0813917885398513 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3863881 3810614 504 L259E Transcriptional coactivator YAP1 Homo sapiens -0.131849502439279 0.112033096789818 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095300 3810614 504 L259E Transcriptional coactivator YAP1 Homo sapiens -0.443609547921324 0.137149302870143 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3863882 3810615 504 L259F Transcriptional coactivator YAP1 Homo sapiens -0.00892060253277218 0.111868524498081 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095301 3810615 504 L259F Transcriptional coactivator YAP1 Homo sapiens 0.0346546958893287 0.0545698512031053 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3863883 3810616 504 L259G Transcriptional coactivator YAP1 Homo sapiens 0.138582793491018 0.0770440148138513 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095302 3810616 504 L259G Transcriptional coactivator YAP1 Homo sapiens -0.143037251315528 0.0653238829365757 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3863884 3810617 504 L259H Transcriptional coactivator YAP1 Homo sapiens -0.140356984071205 0.0919784129675341 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095303 3810617 504 L259H Transcriptional coactivator YAP1 Homo sapiens 0.01080865586666 0.0587256934492929 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3863885 3810618 504 L259I Transcriptional coactivator YAP1 Homo sapiens -0.111510331920493 0.181367825279081 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095304 3810618 504 L259I Transcriptional coactivator YAP1 Homo sapiens 0.0338804893111294 0.0601160666153916 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3863886 3810619 504 L259K Transcriptional coactivator YAP1 Homo sapiens -0.121930975164793 0.087160118860872 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095305 3810619 504 L259K Transcriptional coactivator YAP1 Homo sapiens 0.0459320132920211 0.0745730098545477 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3863887 3810620 504 L259M Transcriptional coactivator YAP1 Homo sapiens -0.0545384427786485 0.0711828556330649 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095566 3810620 504 L259M Transcriptional coactivator YAP1 Homo sapiens -0.169092127372196 0.087414129062377 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3863888 3810621 504 L259N Transcriptional coactivator YAP1 Homo sapiens -0.0143621108092326 0.116754853071467 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095567 3810621 504 L259N Transcriptional coactivator YAP1 Homo sapiens -0.111246244506301 0.0595937516882308 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3863889 3810622 504 L259P Transcriptional coactivator YAP1 Homo sapiens 0.696490868852961 0.164361380389577 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095568 3810622 504 L259P Transcriptional coactivator YAP1 Homo sapiens -0.747394762042138 0.0589431874123813 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3863890 3810623 504 L259Q Transcriptional coactivator YAP1 Homo sapiens -0.0160779004501453 0.0972107990922235 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095569 3810623 504 L259Q Transcriptional coactivator YAP1 Homo sapiens -0.218169504080067 0.0906210789007888 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3863891 3810624 504 L259R Transcriptional coactivator YAP1 Homo sapiens 0.014658050049318 0.0636077590232782 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095570 3810624 504 L259R Transcriptional coactivator YAP1 Homo sapiens -0.0471327098249118 0.0546442800657207 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3863892 3810625 504 L259S Transcriptional coactivator YAP1 Homo sapiens -0.0374729139045294 0.06997826522719 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095571 3810625 504 L259S Transcriptional coactivator YAP1 Homo sapiens -0.100954787278726 0.049548186607481 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3863893 3810626 504 L259T Transcriptional coactivator YAP1 Homo sapiens -0.0385636034053125 0.080342921259161 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095572 3810626 504 L259T Transcriptional coactivator YAP1 Homo sapiens -0.166319942666701 0.0541099183887203 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3863894 3810627 504 L259V Transcriptional coactivator YAP1 Homo sapiens -0.137177548670092 0.105523287595935 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095573 3810627 504 L259V Transcriptional coactivator YAP1 Homo sapiens -0.0848563828695487 0.0611014891608911 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3863895 3810628 504 L259W Transcriptional coactivator YAP1 Homo sapiens 0.145259415410368 0.0525823978468502 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095574 3810628 504 L259W Transcriptional coactivator YAP1 Homo sapiens -0.26053045969176 0.104140730895489 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3863896 3810629 504 L259Y Transcriptional coactivator YAP1 Homo sapiens -0.0144241632841425 0.125281014361806 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095575 3810629 504 L259Y Transcriptional coactivator YAP1 Homo sapiens 0.0213117666911528 0.0560098038264368 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095296 4906064 503 259L Transcriptional coactivator YAP1 Homo sapiens -0.929612913460179 0.0949571131528336 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3865189 3811921 504 D260A Transcriptional coactivator YAP1 Homo sapiens 0.28416306579304 0.085531729766279 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095307 3811921 504 D260A Transcriptional coactivator YAP1 Homo sapiens -0.332887344989948 0.0471180054697575 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3865190 3811922 504 D260C Transcriptional coactivator YAP1 Homo sapiens 0.414538473116214 0.0891228670893669 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095308 3811922 504 D260C Transcriptional coactivator YAP1 Homo sapiens -0.312573373827122 0.0489844003063678 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3865191 3811923 504 D260E Transcriptional coactivator YAP1 Homo sapiens 0.404394608396119 0.109555206342967 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095549 3811923 504 D260E Transcriptional coactivator YAP1 Homo sapiens -0.362752781481351 0.0498675687024691 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3865192 3811924 504 D260F Transcriptional coactivator YAP1 Homo sapiens 0.591299748344266 0.130586026098179 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095550 3811924 504 D260F Transcriptional coactivator YAP1 Homo sapiens -0.673551368286198 0.0673169675690554 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3865193 3811925 504 D260G Transcriptional coactivator YAP1 Homo sapiens 0.587978820157081 0.0837897796013436 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095551 3811925 504 D260G Transcriptional coactivator YAP1 Homo sapiens -0.683633558987497 0.0433587829676287 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3865194 3811926 504 D260H Transcriptional coactivator YAP1 Homo sapiens 0.0893346449034182 0.0921518524706145 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095552 3811926 504 D260H Transcriptional coactivator YAP1 Homo sapiens -0.192176691860089 0.0636073404379637 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3865195 3811927 504 D260I Transcriptional coactivator YAP1 Homo sapiens 0.529254205163014 0.118783430216657 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095553 3811927 504 D260I Transcriptional coactivator YAP1 Homo sapiens -0.542947015271121 0.0612412601038782 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3865196 3811928 504 D260K Transcriptional coactivator YAP1 Homo sapiens 0.234545436937882 0.108290064586539 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095554 3811928 504 D260K Transcriptional coactivator YAP1 Homo sapiens -0.20628507504411 0.0491394246307569 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3865197 3811929 504 D260L Transcriptional coactivator YAP1 Homo sapiens 0.490818658693084 0.0618811824422725 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095555 3811929 504 D260L Transcriptional coactivator YAP1 Homo sapiens -0.518919080465537 0.0432812190855703 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3865198 3811930 504 D260M Transcriptional coactivator YAP1 Homo sapiens 0.346596493206511 0.0862755132541662 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095556 3811930 504 D260M Transcriptional coactivator YAP1 Homo sapiens -0.337376629177205 0.0469842101602774 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3865199 3811931 504 D260N Transcriptional coactivator YAP1 Homo sapiens 0.263181218250728 0.0594099919162765 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095557 3811931 504 D260N Transcriptional coactivator YAP1 Homo sapiens -0.0337778452735263 0.0511987902580608 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3865200 3811932 504 D260P Transcriptional coactivator YAP1 Homo sapiens 0.244710018074325 0.0967124348080203 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095558 3811932 504 D260P Transcriptional coactivator YAP1 Homo sapiens -0.372682995351781 0.0523759025330094 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3865201 3811933 504 D260Q Transcriptional coactivator YAP1 Homo sapiens 0.277753759913101 0.0780253270376643 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095559 3811933 504 D260Q Transcriptional coactivator YAP1 Homo sapiens -0.34745802418829 0.0511382223189728 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3865202 3811934 504 D260R Transcriptional coactivator YAP1 Homo sapiens 0.176553435896196 0.0780580389454989 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095560 3811934 504 D260R Transcriptional coactivator YAP1 Homo sapiens -0.089017842688647 0.0413273858513461 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3865203 3811935 504 D260S Transcriptional coactivator YAP1 Homo sapiens 0.360059913271426 0.0789400001427306 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095561 3811935 504 D260S Transcriptional coactivator YAP1 Homo sapiens -0.34617139311229 0.044032390432075 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3865204 3811936 504 D260T Transcriptional coactivator YAP1 Homo sapiens 0.450122524718235 0.0683572726021599 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095562 3811936 504 D260T Transcriptional coactivator YAP1 Homo sapiens -0.483483096355105 0.048406291581403 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3865205 3811937 504 D260V Transcriptional coactivator YAP1 Homo sapiens 0.397979541079367 0.142911832460154 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095563 3811937 504 D260V Transcriptional coactivator YAP1 Homo sapiens -0.411826975428366 0.0451684450919824 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3865206 3811938 504 D260W Transcriptional coactivator YAP1 Homo sapiens 0.640027730335509 0.141648063546091 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095564 3811938 504 D260W Transcriptional coactivator YAP1 Homo sapiens -0.738762955462875 0.0454370621513189 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3865207 3811939 504 D260Y Transcriptional coactivator YAP1 Homo sapiens 0.390208611882018 0.10393900950193 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095565 3811939 504 D260Y Transcriptional coactivator YAP1 Homo sapiens -0.357910210839089 0.0576062289303469 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095306 4906065 503 260D Transcriptional coactivator YAP1 Homo sapiens -1.12623433085554 0.0585268902493308 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3866500 3813231 504 P261A Transcriptional coactivator YAP1 Homo sapiens 0.865549429395288 0.113073137409568 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095310 3813231 504 P261A Transcriptional coactivator YAP1 Homo sapiens -0.940019188785631 0.0537243189541251 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3866501 3813232 504 P261C Transcriptional coactivator YAP1 Homo sapiens 0.97496218646365 0.100129360685518 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095311 3813232 504 P261C Transcriptional coactivator YAP1 Homo sapiens -0.866496060340817 0.0617197086295424 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3866502 3813233 504 P261D Transcriptional coactivator YAP1 Homo sapiens 0.937759024831088 0.125190890636368 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095312 3813233 504 P261D Transcriptional coactivator YAP1 Homo sapiens -1.10001769097837 0.0748494644624918 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3866503 3813234 504 P261E Transcriptional coactivator YAP1 Homo sapiens 0.609015333832266 0.117102092167429 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095313 3813234 504 P261E Transcriptional coactivator YAP1 Homo sapiens -0.967112361002518 0.0563645623083384 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3866504 3813235 504 P261F Transcriptional coactivator YAP1 Homo sapiens 1.14354404437385 0.0680127656875614 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095314 3813235 504 P261F Transcriptional coactivator YAP1 Homo sapiens -0.828515856771194 0.0639802486136461 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3866505 3813236 504 P261G Transcriptional coactivator YAP1 Homo sapiens 0.738204976694459 0.0629609398417617 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095315 3813236 504 P261G Transcriptional coactivator YAP1 Homo sapiens -0.927893586045818 0.0436535384504943 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3866506 3813237 504 P261H Transcriptional coactivator YAP1 Homo sapiens 0.867491258656922 0.0888594051361053 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095316 3813237 504 P261H Transcriptional coactivator YAP1 Homo sapiens -0.845778435532441 0.0925306558453116 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3866507 3813238 504 P261I Transcriptional coactivator YAP1 Homo sapiens 0.911741906571564 0.113378797386352 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095317 3813238 504 P261I Transcriptional coactivator YAP1 Homo sapiens -0.759033641078061 0.0720756247213518 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3866508 3813239 504 P261K Transcriptional coactivator YAP1 Homo sapiens 0.969472246108992 0.164068042235662 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095318 3813239 504 P261K Transcriptional coactivator YAP1 Homo sapiens -1.07401015848944 0.0685324718968284 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3866509 3813240 504 P261L Transcriptional coactivator YAP1 Homo sapiens 0.883113372065958 0.0897354361044313 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095319 3813240 504 P261L Transcriptional coactivator YAP1 Homo sapiens -0.614814948932821 0.0468671561728992 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3866510 3813241 504 P261M Transcriptional coactivator YAP1 Homo sapiens 0.789301426844357 0.086186481050937 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095320 3813241 504 P261M Transcriptional coactivator YAP1 Homo sapiens -0.506124222686749 0.0528778477906923 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3866511 3813242 504 P261N Transcriptional coactivator YAP1 Homo sapiens 1.11222406366395 0.159903243600478 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095321 3813242 504 P261N Transcriptional coactivator YAP1 Homo sapiens -1.02358472342105 0.0738194355235968 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3866512 3813243 504 P261Q Transcriptional coactivator YAP1 Homo sapiens 0.733678917966698 0.195303491864841 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095542 3813243 504 P261Q Transcriptional coactivator YAP1 Homo sapiens -0.835638398152586 0.060354908946921 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3866513 3813244 504 P261R Transcriptional coactivator YAP1 Homo sapiens 0.950483248051953 0.164808780714172 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095543 3813244 504 P261R Transcriptional coactivator YAP1 Homo sapiens -1.06632028998548 0.046488105268765 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3866514 3813245 504 P261S Transcriptional coactivator YAP1 Homo sapiens 0.833486358370367 0.0818786254896088 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095544 3813245 504 P261S Transcriptional coactivator YAP1 Homo sapiens -0.97747654431565 0.0483326504520994 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3866515 3813246 504 P261T Transcriptional coactivator YAP1 Homo sapiens 0.89465747973459 0.0985810308064319 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095545 3813246 504 P261T Transcriptional coactivator YAP1 Homo sapiens -0.956722476895474 0.0623309021536044 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3866516 3813247 504 P261V Transcriptional coactivator YAP1 Homo sapiens 0.800497440203752 0.0826247990735484 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095546 3813247 504 P261V Transcriptional coactivator YAP1 Homo sapiens -0.606350714712622 0.045804949521751 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3866517 3813248 504 P261W Transcriptional coactivator YAP1 Homo sapiens 1.10055089756017 0.155801089337814 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095547 3813248 504 P261W Transcriptional coactivator YAP1 Homo sapiens -0.890172618347909 0.0492792990134718 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 3866518 3813249 504 P261Y Transcriptional coactivator YAP1 Homo sapiens 1.17624604973893 0.153911450591672 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome DDG 5095548 3813249 504 P261Y Transcriptional coactivator YAP1 Homo sapiens -1.1654306275637 0.104466247762027 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095309 4906066 503 261P Transcriptional coactivator YAP1 Homo sapiens -1.24904991107306 0.0810232248327373 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095322 4906067 503 262R Transcriptional coactivator YAP1 Homo sapiens -1.15126526500345 0.077524431737643 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095323 4906068 504 R262A Transcriptional coactivator YAP1 Homo sapiens -0.347348218938761 0.0508068014310473 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095324 4906069 504 R262C Transcriptional coactivator YAP1 Homo sapiens -0.382488285858616 0.0585647810173204 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095325 4906070 504 R262D Transcriptional coactivator YAP1 Homo sapiens -0.742942795725917 0.0830457897876447 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095326 4906071 504 R262E Transcriptional coactivator YAP1 Homo sapiens -0.675929606766753 0.052380207217067 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095327 4906072 504 R262F Transcriptional coactivator YAP1 Homo sapiens -0.501533806273296 0.0729175365798584 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095328 4906073 504 R262G Transcriptional coactivator YAP1 Homo sapiens -0.303943317766331 0.0430411593480135 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095329 4906074 504 R262H Transcriptional coactivator YAP1 Homo sapiens -0.524451116678211 0.0819042926066737 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095330 4906075 504 R262I Transcriptional coactivator YAP1 Homo sapiens -0.739380808914028 0.072659279407108 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095331 4906076 504 R262K Transcriptional coactivator YAP1 Homo sapiens -0.271266707748948 0.0596074534737155 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095332 4906077 504 R262L Transcriptional coactivator YAP1 Homo sapiens -0.411141090463918 0.0489181033977392 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095333 4906078 504 R262M Transcriptional coactivator YAP1 Homo sapiens -0.482465726847514 0.059339114905954 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095334 4906079 504 R262N Transcriptional coactivator YAP1 Homo sapiens -0.491241632924528 0.0726481079165038 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095335 4906080 504 R262P Transcriptional coactivator YAP1 Homo sapiens -0.962927030477 0.0659913078880594 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095336 4906081 504 R262Q Transcriptional coactivator YAP1 Homo sapiens -0.28652565898238 0.060413376263844 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095537 4906282 504 R262S Transcriptional coactivator YAP1 Homo sapiens -0.191055564348595 0.0507246464164542 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095538 4906283 504 R262T Transcriptional coactivator YAP1 Homo sapiens -0.245478387913962 0.078747678131198 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095539 4906284 504 R262V Transcriptional coactivator YAP1 Homo sapiens -0.429339639623866 0.0500719019494184 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095540 4906285 504 R262W Transcriptional coactivator YAP1 Homo sapiens -0.503655593797886 0.0467164206187635 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095541 4906286 504 R262Y Transcriptional coactivator YAP1 Homo sapiens -0.68364907494667 0.0954399379746747 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095337 4906082 503 263L Transcriptional coactivator YAP1 Homo sapiens -1.26681440326439 0.0868555545321653 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095338 4906083 504 L263A Transcriptional coactivator YAP1 Homo sapiens 0.0468040897665395 0.0451921884879675 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095339 4906084 504 L263C Transcriptional coactivator YAP1 Homo sapiens 0.0936996839076863 0.0471055370041045 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095340 4906085 504 L263D Transcriptional coactivator YAP1 Homo sapiens 0.0846216542564257 0.0598333817530721 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095341 4906086 504 L263E Transcriptional coactivator YAP1 Homo sapiens 0.0349101124480153 0.0509658042065062 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095342 4906087 504 L263F Transcriptional coactivator YAP1 Homo sapiens -0.0208558361985441 0.0518095381956029 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095343 4906088 504 L263G Transcriptional coactivator YAP1 Homo sapiens 0.0890377349439966 0.0425505367620755 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095344 4906089 504 L263H Transcriptional coactivator YAP1 Homo sapiens 0.014264338465961 0.0576891557644476 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095345 4906090 504 L263I Transcriptional coactivator YAP1 Homo sapiens 0.0307677491940524 0.0612105464616187 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095346 4906091 504 L263K Transcriptional coactivator YAP1 Homo sapiens 0.196142411886549 0.0599898462767485 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095527 4906272 504 L263M Transcriptional coactivator YAP1 Homo sapiens -0.00930002722096005 0.0581713201634111 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095528 4906273 504 L263N Transcriptional coactivator YAP1 Homo sapiens 0.123265940878634 0.0666731984876332 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095529 4906274 504 L263P Transcriptional coactivator YAP1 Homo sapiens -0.00623184575586565 0.0488544959220339 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095530 4906275 504 L263Q Transcriptional coactivator YAP1 Homo sapiens 0.0420792812759456 0.0576388840567285 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095531 4906276 504 L263R Transcriptional coactivator YAP1 Homo sapiens 0.0398481659159549 0.0431615313635839 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095532 4906277 504 L263S Transcriptional coactivator YAP1 Homo sapiens 0.138340291982423 0.045792481056098 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095533 4906278 504 L263T Transcriptional coactivator YAP1 Homo sapiens 0.15696183006012 0.0514066802402665 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095534 4906279 504 L263V Transcriptional coactivator YAP1 Homo sapiens 0.0787940191292601 0.0456217816344935 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095535 4906280 504 L263W Transcriptional coactivator YAP1 Homo sapiens -0.10380892807626 0.0459352676649961 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095536 4906281 504 L263Y Transcriptional coactivator YAP1 Homo sapiens -0.0405714483204596 0.0583272515746441 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 7.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095347 4906092 503 264D Transcriptional coactivator YAP1 Homo sapiens -1.22921785366679 0.0644104703554411 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095348 4906093 504 D264A Transcriptional coactivator YAP1 Homo sapiens 0.0278109643589148 0.0437632004757846 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095349 4906094 504 D264C Transcriptional coactivator YAP1 Homo sapiens 0.256932348544157 0.0541599195617666 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095510 4906255 504 D264E Transcriptional coactivator YAP1 Homo sapiens 0.0672246834180383 0.0475865396953556 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095511 4906256 504 D264F Transcriptional coactivator YAP1 Homo sapiens 0.0984865562349703 0.0519491500005472 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095512 4906257 504 D264G Transcriptional coactivator YAP1 Homo sapiens -0.0040938261509103 0.0427119106943721 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095513 4906258 504 D264H Transcriptional coactivator YAP1 Homo sapiens 0.0950109813803199 0.0573109085074295 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095514 4906259 504 D264I Transcriptional coactivator YAP1 Homo sapiens 0.0713527242481497 0.0623182665930064 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095515 4906260 504 D264K Transcriptional coactivator YAP1 Homo sapiens 0.0242550247926528 0.0539508440011421 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095516 4906261 504 D264L Transcriptional coactivator YAP1 Homo sapiens 0.112272684882331 0.0428628213003549 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095517 4906262 504 D264M Transcriptional coactivator YAP1 Homo sapiens 0.105699488024669 0.0534218054916732 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095518 4906263 504 D264N Transcriptional coactivator YAP1 Homo sapiens -7.32034996857561E-5 0.0550545061124385 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095519 4906264 504 D264P Transcriptional coactivator YAP1 Homo sapiens -0.0596910884721066 0.0522448205271588 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095520 4906265 504 D264Q Transcriptional coactivator YAP1 Homo sapiens 0.104738294246186 0.0515272352645861 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095521 4906266 504 D264R Transcriptional coactivator YAP1 Homo sapiens -0.108497134817012 0.043863990555189 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095522 4906267 504 D264S Transcriptional coactivator YAP1 Homo sapiens -0.0174494863925098 0.0440061087843074 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095523 4906268 504 D264T Transcriptional coactivator YAP1 Homo sapiens 0.00327346954030033 0.0500121535712508 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095524 4906269 504 D264V Transcriptional coactivator YAP1 Homo sapiens 0.07134078889494 0.0439993215467822 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095525 4906270 504 D264W Transcriptional coactivator YAP1 Homo sapiens 0.223431403465095 0.0470715292043592 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095526 4906271 504 D264Y Transcriptional coactivator YAP1 Homo sapiens 0.02606124157838 0.0519118560002181 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095350 4906095 503 265P Transcriptional coactivator YAP1 Homo sapiens -1.12937929642629 0.0769469754786537 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095351 4906096 504 P265A Transcriptional coactivator YAP1 Homo sapiens 0.033826382376579 0.0448877335413936 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095352 4906097 504 P265C Transcriptional coactivator YAP1 Homo sapiens 0.00549821937857921 0.0466004010286635 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095353 4906098 504 P265D Transcriptional coactivator YAP1 Homo sapiens 0.124945642920339 0.0520983817001786 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095354 4906099 504 P265E Transcriptional coactivator YAP1 Homo sapiens 0.0646546040268936 0.0523078869335186 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095355 4906100 504 P265F Transcriptional coactivator YAP1 Homo sapiens 0.0594738650436909 0.049818944073493 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095356 4906101 504 P265G Transcriptional coactivator YAP1 Homo sapiens 0.0880550575297353 0.043262926167551 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095357 4906102 504 P265H Transcriptional coactivator YAP1 Homo sapiens -0.00990236471294031 0.0629867498124747 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095358 4906103 504 P265I Transcriptional coactivator YAP1 Homo sapiens 0.0679837718821721 0.0514144859612656 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095359 4906104 504 P265K Transcriptional coactivator YAP1 Homo sapiens 0.0322994528559577 0.0545671219856713 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095360 4906105 504 P265L Transcriptional coactivator YAP1 Homo sapiens 0.0998821968702855 0.0445542438589117 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095361 4906106 504 P265M Transcriptional coactivator YAP1 Homo sapiens 0.0548461307592023 0.0522143455919635 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095362 4906107 504 P265N Transcriptional coactivator YAP1 Homo sapiens 0.0476252420673634 0.0499720348706621 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095503 4906248 504 P265Q Transcriptional coactivator YAP1 Homo sapiens 0.0927766832594732 0.0597609262021874 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095504 4906249 504 P265R Transcriptional coactivator YAP1 Homo sapiens 0.0101402760869196 0.0435015616196247 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095505 4906250 504 P265S Transcriptional coactivator YAP1 Homo sapiens 0.0818988023441974 0.0432612552181016 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095506 4906251 504 P265T Transcriptional coactivator YAP1 Homo sapiens 0.128267649563691 0.0474174157403748 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095507 4906252 504 P265V Transcriptional coactivator YAP1 Homo sapiens 0.0316541480924225 0.0439918181880644 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095508 4906253 504 P265W Transcriptional coactivator YAP1 Homo sapiens 0.175005697042471 0.049880482754642 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095509 4906254 504 P265Y Transcriptional coactivator YAP1 Homo sapiens -0.0284634303343757 0.0508777531274276 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 2.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095363 4906108 503 266R Transcriptional coactivator YAP1 Homo sapiens -1.22635057363675 0.0770462060052387 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095364 4906109 504 R266A Transcriptional coactivator YAP1 Homo sapiens 0.0958655526701309 0.0473096235870874 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095365 4906110 504 R266C Transcriptional coactivator YAP1 Homo sapiens 0.104553694116543 0.0561628309683888 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095366 4906111 504 R266D Transcriptional coactivator YAP1 Homo sapiens 0.0455954363315087 0.0588210012231231 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095367 4906112 504 R266E Transcriptional coactivator YAP1 Homo sapiens 0.0778352124214182 0.0474359553223605 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095368 4906113 504 R266F Transcriptional coactivator YAP1 Homo sapiens 0.420704491145705 0.0650543428765911 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095369 4906114 504 R266G Transcriptional coactivator YAP1 Homo sapiens 0.04521748347987 0.0434178231815058 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095370 4906115 504 R266H Transcriptional coactivator YAP1 Homo sapiens 0.0888324468687906 0.0761175479996044 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095371 4906116 504 R266I Transcriptional coactivator YAP1 Homo sapiens 0.258313666755621 0.0701145029647676 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095372 4906117 504 R266K Transcriptional coactivator YAP1 Homo sapiens 0.0115749055427196 0.0571532584053343 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095373 4906118 504 R266L Transcriptional coactivator YAP1 Homo sapiens 0.26615678519479 0.0460949945185498 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095374 4906119 504 R266M Transcriptional coactivator YAP1 Homo sapiens 0.170642927599237 0.0574076883081554 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095375 4906120 504 R266N Transcriptional coactivator YAP1 Homo sapiens 0.0533390934939304 0.0684879450724542 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095376 4906121 504 R266P Transcriptional coactivator YAP1 Homo sapiens 0.171073396004998 0.0554178978331617 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095377 4906122 504 R266Q Transcriptional coactivator YAP1 Homo sapiens 0.112554359218079 0.054785427552778 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095498 4906243 504 R266S Transcriptional coactivator YAP1 Homo sapiens 0.0765438072041339 0.0474730106156254 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095499 4906244 504 R266T Transcriptional coactivator YAP1 Homo sapiens 0.114394790683007 0.0555663656701876 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095500 4906245 504 R266V Transcriptional coactivator YAP1 Homo sapiens 0.156214676949196 0.0449382837406875 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095501 4906246 504 R266W Transcriptional coactivator YAP1 Homo sapiens 0.286255124309628 0.0503291645094013 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095502 4906247 504 R266Y Transcriptional coactivator YAP1 Homo sapiens 0.180164952389896 0.0718812853434901 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 6.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095378 4906123 503 267F Transcriptional coactivator YAP1 Homo sapiens -1.18853658020454 0.0935747605440919 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095379 4906124 504 F267A Transcriptional coactivator YAP1 Homo sapiens -0.0280966171457323 0.0500490497264729 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095380 4906125 504 F267C Transcriptional coactivator YAP1 Homo sapiens 0.0396611787156703 0.0623252766237916 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095381 4906126 504 F267D Transcriptional coactivator YAP1 Homo sapiens -0.0227161599188217 0.0606567381157888 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095382 4906127 504 F267E Transcriptional coactivator YAP1 Homo sapiens 0.0266619876899325 0.0499507660712425 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095483 4906228 504 F267G Transcriptional coactivator YAP1 Homo sapiens 0.025962575991847 0.043900767356879 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095484 4906229 504 F267H Transcriptional coactivator YAP1 Homo sapiens -0.0322246579758437 0.0879846389457983 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095485 4906230 504 F267I Transcriptional coactivator YAP1 Homo sapiens -0.0292384326027891 0.072460197715571 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095486 4906231 504 F267K Transcriptional coactivator YAP1 Homo sapiens -0.159744358738397 0.0620344438936809 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095487 4906232 504 F267L Transcriptional coactivator YAP1 Homo sapiens 0.0122576077463116 0.0465458087230826 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095488 4906233 504 F267M Transcriptional coactivator YAP1 Homo sapiens -0.0342377542172049 0.0604092545885356 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095489 4906234 504 F267N Transcriptional coactivator YAP1 Homo sapiens 0.0422121615416798 0.0694248384718033 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095490 4906235 504 F267P Transcriptional coactivator YAP1 Homo sapiens 0.0491513758977708 0.0655422282881931 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095491 4906236 504 F267Q Transcriptional coactivator YAP1 Homo sapiens 0.0530701502016062 0.0737792133832802 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095492 4906237 504 F267R Transcriptional coactivator YAP1 Homo sapiens -0.00382408716837216 0.0443167939852567 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095493 4906238 504 F267S Transcriptional coactivator YAP1 Homo sapiens 0.0366128895059255 0.050907551725941 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095494 4906239 504 F267T Transcriptional coactivator YAP1 Homo sapiens 0.0404019663048828 0.0559839916358954 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095495 4906240 504 F267V Transcriptional coactivator YAP1 Homo sapiens 0.0498348737915768 0.0459566001196328 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095496 4906241 504 F267W Transcriptional coactivator YAP1 Homo sapiens -0.0206330429386306 0.0480961474497991 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095497 4906242 504 F267Y Transcriptional coactivator YAP1 Homo sapiens -0.0481488062281602 0.073225333425331 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095383 4906128 503 268A Transcriptional coactivator YAP1 Homo sapiens -1.19042967044783 0.117626884332181 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095464 4906209 504 A268C Transcriptional coactivator YAP1 Homo sapiens -0.0331882388249696 0.0574162817624664 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095465 4906210 504 A268D Transcriptional coactivator YAP1 Homo sapiens 0.0179897600478001 0.0711496402348364 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095466 4906211 504 A268E Transcriptional coactivator YAP1 Homo sapiens 0.0650436965415281 0.109545217966862 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095467 4906212 504 A268F Transcriptional coactivator YAP1 Homo sapiens -4.77414128377684E-6 0.0546654931668253 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095468 4906213 504 A268G Transcriptional coactivator YAP1 Homo sapiens -0.0181146834113942 0.0509614279103294 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095469 4906214 504 A268H Transcriptional coactivator YAP1 Homo sapiens -0.0577933673117721 0.0509840175555042 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095470 4906215 504 A268I Transcriptional coactivator YAP1 Homo sapiens -0.105436910254057 0.0569797979386873 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095471 4906216 504 A268K Transcriptional coactivator YAP1 Homo sapiens 0.0110298577461455 0.0623192612057739 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095472 4906217 504 A268L Transcriptional coactivator YAP1 Homo sapiens -0.0427532308871838 0.049302931012827 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095473 4906218 504 A268M Transcriptional coactivator YAP1 Homo sapiens 0.0409605408350944 0.0628924684790206 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095474 4906219 504 A268N Transcriptional coactivator YAP1 Homo sapiens 0.0747129240217734 0.0541098626904053 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095475 4906220 504 A268P Transcriptional coactivator YAP1 Homo sapiens 0.0777389339055269 0.0545561255469142 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095476 4906221 504 A268Q Transcriptional coactivator YAP1 Homo sapiens -0.0296649225574805 0.0877758498336508 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095477 4906222 504 A268R Transcriptional coactivator YAP1 Homo sapiens -0.0140152874289862 0.050263734903106 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095478 4906223 504 A268S Transcriptional coactivator YAP1 Homo sapiens 0.0230034040860674 0.048584311352976 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095479 4906224 504 A268T Transcriptional coactivator YAP1 Homo sapiens 0.020382400521228 0.0535520758935055 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095480 4906225 504 A268V Transcriptional coactivator YAP1 Homo sapiens 0.0174908622836367 0.0513287980821224 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095481 4906226 504 A268W Transcriptional coactivator YAP1 Homo sapiens -0.0242510463415828 0.0618357282196424 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095482 4906227 504 A268Y Transcriptional coactivator YAP1 Homo sapiens -0.195545644226066 0.0530473298062694 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095384 4906129 503 269M Transcriptional coactivator YAP1 Homo sapiens -1.38840725428699 0.119565503969513 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095385 4906130 504 M269A Transcriptional coactivator YAP1 Homo sapiens -0.0630950512074992 0.0518653160796027 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095386 4906131 504 M269C Transcriptional coactivator YAP1 Homo sapiens -0.167557240949435 0.056827892719937 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095387 4906132 504 M269D Transcriptional coactivator YAP1 Homo sapiens 0.154856433753938 0.0627597791789379 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095388 4906133 504 M269E Transcriptional coactivator YAP1 Homo sapiens -0.33083685130853 0.279786003731954 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095389 4906134 504 M269F Transcriptional coactivator YAP1 Homo sapiens 0.019772901817322 0.0456208268062368 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095390 4906135 504 M269G Transcriptional coactivator YAP1 Homo sapiens -0.00116966461454586 0.0586687936420915 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095391 4906136 504 M269H Transcriptional coactivator YAP1 Homo sapiens -0.106336040195851 0.0476241440148681 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095392 4906137 504 M269I Transcriptional coactivator YAP1 Homo sapiens 0.0161922958544266 0.0450616475514625 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095393 4906138 504 M269K Transcriptional coactivator YAP1 Homo sapiens -0.0223071751488376 0.0636408389959722 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095394 4906139 504 M269L Transcriptional coactivator YAP1 Homo sapiens -0.0663247577860306 0.0436358900415483 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095455 4906200 504 M269N Transcriptional coactivator YAP1 Homo sapiens 0.0226246555442144 0.0488825917434895 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095456 4906201 504 M269P Transcriptional coactivator YAP1 Homo sapiens -0.153979583138136 0.0450404503641621 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095457 4906202 504 M269Q Transcriptional coactivator YAP1 Homo sapiens 0.0106519048945065 0.0571329364772693 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095458 4906203 504 M269R Transcriptional coactivator YAP1 Homo sapiens -0.0899686924943492 0.0472216520770301 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095459 4906204 504 M269S Transcriptional coactivator YAP1 Homo sapiens -0.0481535803694439 0.0444602410170325 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095460 4906205 504 M269T Transcriptional coactivator YAP1 Homo sapiens 0.0293315283578244 0.0458447658600584 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095461 4906206 504 M269V Transcriptional coactivator YAP1 Homo sapiens -0.0538714102470806 0.0550214770116563 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095462 4906207 504 M269W Transcriptional coactivator YAP1 Homo sapiens -0.0246775362962745 0.066742813424454 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095463 4906208 504 M269Y Transcriptional coactivator YAP1 Homo sapiens -0.0868647049696261 0.0503689012786873 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095395 4906140 503 270N Transcriptional coactivator YAP1 Homo sapiens -1.070226731091 0.0911228411497225 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095396 4906141 504 N270A Transcriptional coactivator YAP1 Homo sapiens -0.0695608298862741 0.0502969470126374 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095397 4906142 504 N270C Transcriptional coactivator YAP1 Homo sapiens -0.0989345298254391 0.0582599839239545 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095398 4906143 504 N270D Transcriptional coactivator YAP1 Homo sapiens -0.152163022379627 0.10779509734122 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095399 4906144 504 N270E Transcriptional coactivator YAP1 Homo sapiens -0.111835055264644 0.0848644989097313 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095400 4906145 504 N270F Transcriptional coactivator YAP1 Homo sapiens -0.0974426106742327 0.0463532914758109 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095401 4906146 504 N270G Transcriptional coactivator YAP1 Homo sapiens -0.102785670461087 0.0553349550852568 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095402 4906147 504 N270H Transcriptional coactivator YAP1 Homo sapiens -0.0847044060386792 0.0486659332551257 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095403 4906148 504 N270I Transcriptional coactivator YAP1 Homo sapiens -0.0755149797574618 0.0501280935923294 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095404 4906149 504 N270K Transcriptional coactivator YAP1 Homo sapiens -0.228593045883162 0.0606627137492958 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095405 4906150 504 N270L Transcriptional coactivator YAP1 Homo sapiens 0.0316127722012957 0.0441572183128437 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095406 4906151 504 N270M Transcriptional coactivator YAP1 Homo sapiens -0.0612275662752957 0.0541966884065545 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095447 4906192 504 N270P Transcriptional coactivator YAP1 Homo sapiens -0.182710365384407 0.0461286203869924 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095448 4906193 504 N270Q Transcriptional coactivator YAP1 Homo sapiens -0.174526691533657 0.0632282338355145 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095449 4906194 504 N270R Transcriptional coactivator YAP1 Homo sapiens -0.190717396007655 0.0484578761779751 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095450 4906195 504 N270S Transcriptional coactivator YAP1 Homo sapiens -0.128542958377727 0.0452830881380122 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095451 4906196 504 N270T Transcriptional coactivator YAP1 Homo sapiens -0.124297951086162 0.0453957340016049 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095452 4906197 504 N270V Transcriptional coactivator YAP1 Homo sapiens -0.10192791641042 0.0541697861204199 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095453 4906198 504 N270W Transcriptional coactivator YAP1 Homo sapiens -0.101464029015671 0.0861933811360939 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095454 4906199 504 N270Y Transcriptional coactivator YAP1 Homo sapiens -0.192425742897063 0.0487088607421698 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 5.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095407 4906152 503 271Q Transcriptional coactivator YAP1 Homo sapiens -1.09353273616544 0.0980068346049637 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095408 4906153 504 Q271A Transcriptional coactivator YAP1 Homo sapiens -0.12372346275167 0.0510938785033479 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095409 4906154 504 Q271C Transcriptional coactivator YAP1 Homo sapiens -0.315781596769876 0.0645859120907209 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095410 4906155 504 Q271D Transcriptional coactivator YAP1 Homo sapiens 0.154135538420075 0.0650180196183231 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095411 4906156 504 Q271E Transcriptional coactivator YAP1 Homo sapiens 0.0533693297220615 0.0724073400146565 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095412 4906157 504 Q271F Transcriptional coactivator YAP1 Homo sapiens -0.0868543609968443 0.0658226931748156 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095413 4906158 504 Q271G Transcriptional coactivator YAP1 Homo sapiens 0.00995965440834673 0.0463645425354366 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095414 4906159 504 Q271H Transcriptional coactivator YAP1 Homo sapiens -0.0134630784204863 0.0665285022222215 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095415 4906160 504 Q271I Transcriptional coactivator YAP1 Homo sapiens -0.128282767677757 0.0705579888624297 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095416 4906161 504 Q271K Transcriptional coactivator YAP1 Homo sapiens 0.117474907501311 0.0688585775741246 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095417 4906162 504 Q271L Transcriptional coactivator YAP1 Homo sapiens -0.11478945302914 0.0534036000995774 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095418 4906163 504 Q271M Transcriptional coactivator YAP1 Homo sapiens -0.0703676597632465 0.0761530437400499 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095419 4906164 504 Q271N Transcriptional coactivator YAP1 Homo sapiens 0.065906224733479 0.0678470006912917 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095420 4906165 504 Q271P Transcriptional coactivator YAP1 Homo sapiens -0.283249802371438 0.0617119029085433 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095441 4906186 504 Q271R Transcriptional coactivator YAP1 Homo sapiens -0.138788265572892 0.047813311406339 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095442 4906187 504 Q271S Transcriptional coactivator YAP1 Homo sapiens -0.0384135364601547 0.0503073864682448 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095443 4906188 504 Q271T Transcriptional coactivator YAP1 Homo sapiens -0.055781862450839 0.0586955606608896 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095444 4906189 504 Q271V Transcriptional coactivator YAP1 Homo sapiens -0.0669334607997229 0.0496473932633596 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095445 4906190 504 Q271W Transcriptional coactivator YAP1 Homo sapiens -0.240132145366252 0.0615681137299756 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095446 4906191 504 Q271Y Transcriptional coactivator YAP1 Homo sapiens -0.0577002715567368 0.0701543272599771 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 8.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095421 4906166 503 272R Transcriptional coactivator YAP1 Homo sapiens -1.18852524161899 0.44363262293753 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095422 4906167 504 R272A Transcriptional coactivator YAP1 Homo sapiens -0.0912234959617906 0.231483151878368 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095423 4906168 504 R272C Transcriptional coactivator YAP1 Homo sapiens -0.343084910772274 0.0783790428119648 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095424 4906169 504 R272D Transcriptional coactivator YAP1 Homo sapiens 0.082665847710471 0.0836544132323155 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095425 4906170 504 R272E Transcriptional coactivator YAP1 Homo sapiens -0.0829761668939217 1.39366652789431 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095426 4906171 504 R272F Transcriptional coactivator YAP1 Homo sapiens -0.0852749159221006 0.107296040439014 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095427 4906172 504 R272G Transcriptional coactivator YAP1 Homo sapiens 0.0380968517549921 0.0919287957674596 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095428 4906173 504 R272H Transcriptional coactivator YAP1 Homo sapiens -0.152145517194919 0.111110022341668 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095429 4906174 504 R272I Transcriptional coactivator YAP1 Homo sapiens 0.0602035129699076 0.122407709413838 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095430 4906175 504 R272K Transcriptional coactivator YAP1 Homo sapiens -0.262946970871607 0.144239459659825 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095431 4906176 504 R272L Transcriptional coactivator YAP1 Homo sapiens -0.139831415443415 0.0783345557721013 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095432 4906177 504 R272M Transcriptional coactivator YAP1 Homo sapiens -0.177640227340948 0.102679843662628 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095433 4906178 504 R272N Transcriptional coactivator YAP1 Homo sapiens 0.0196575267362953 0.0737275173900782 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095434 4906179 504 R272P Transcriptional coactivator YAP1 Homo sapiens -0.311143518512606 0.0826285298394353 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095435 4906180 504 R272Q Transcriptional coactivator YAP1 Homo sapiens -0.336273802540633 0.25964350381024 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095436 4906181 504 R272S Transcriptional coactivator YAP1 Homo sapiens -0.102122860512844 0.0706900734379498 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095437 4906182 504 R272T Transcriptional coactivator YAP1 Homo sapiens -0.0537234118672811 0.0684793516181433 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095438 4906183 504 R272V Transcriptional coactivator YAP1 Homo sapiens -0.177055395033675 0.0830283641719586 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095439 4906184 504 R272W Transcriptional coactivator YAP1 Homo sapiens -0.21107513013225 0.11129287195284 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 5095440 4906185 504 R272Y Transcriptional coactivator YAP1 Homo sapiens -0.0933551500450341 0.0700183835869192 P46937 IPR053819:TEADIR3_omega_loop, IPR001202:WW_dom, IPR036020:WW_dom_sf, IPR051583:YAP1 4.0 1K9Q 39779847 10.1038/s41586-024-08370-4 2025 Domainome FITNESS 19092 246 669 Alpha-amylase Pseudoalteromonas haloplanktis 238.0 yes 43.7 MOPS 30 mM NaCl 50 mM DSC Thermal 7.2 3.2.1.1 P29957 IPR006048:A-amylase/branching_C, IPR031319:A-amylase_C, IPR006046:Alpha_amylase, IPR006047:Glyco_hydro_13_cat_dom, IPR013780:Glyco_hydro_b, IPR017853:Glycoside_hydrolase_SF 10194383 10.1021/bi982650+ 1999 ProTherm 19104 246 669 Alpha-amylase Pseudoalteromonas haloplanktis 138.0 135.0 yes 30.6 MES 30 mM NaCl 50 mM DSC Thermal 5.7 3.2.1.1 P29957 IPR006048:A-amylase/branching_C, IPR031319:A-amylase_C, IPR006046:Alpha_amylase, IPR006047:Glyco_hydro_13_cat_dom, IPR013780:Glyco_hydro_b, IPR017853:Glycoside_hydrolase_SF 10194383 10.1021/bi982650+ 1999 ProTherm 19105 246 669 Alpha-amylase Pseudoalteromonas haloplanktis 139.0 145.0 yes 32.0 MES 30 mM NaCl 50 mM DSC Thermal 5.8 3.2.1.1 P29957 IPR006048:A-amylase/branching_C, IPR031319:A-amylase_C, IPR006046:Alpha_amylase, IPR006047:Glyco_hydro_13_cat_dom, IPR013780:Glyco_hydro_b, IPR017853:Glycoside_hydrolase_SF 10194383 10.1021/bi982650+ 1999 ProTherm 19106 246 669 Alpha-amylase Pseudoalteromonas haloplanktis 166.0 175.0 yes 34.4 MES 30 mM NaCl 50 mM DSC Thermal 5.9 3.2.1.1 P29957 IPR006048:A-amylase/branching_C, IPR031319:A-amylase_C, IPR006046:Alpha_amylase, IPR006047:Glyco_hydro_13_cat_dom, IPR013780:Glyco_hydro_b, IPR017853:Glycoside_hydrolase_SF 10194383 10.1021/bi982650+ 1999 ProTherm 19107 246 669 Alpha-amylase Pseudoalteromonas haloplanktis 159.0 166.0 yes 34.7 MES 30 mM NaCl 50 mM DSC Thermal 6.0 3.2.1.1 P29957 IPR006048:A-amylase/branching_C, IPR031319:A-amylase_C, IPR006046:Alpha_amylase, IPR006047:Glyco_hydro_13_cat_dom, IPR013780:Glyco_hydro_b, IPR017853:Glycoside_hydrolase_SF 10194383 10.1021/bi982650+ 1999 ProTherm 19108 246 669 Alpha-amylase Pseudoalteromonas haloplanktis 179.0 188.0 yes 37.3 MES 30 mM NaCl 50 mM DSC Thermal 6.1 3.2.1.1 P29957 IPR006048:A-amylase/branching_C, IPR031319:A-amylase_C, IPR006046:Alpha_amylase, IPR006047:Glyco_hydro_13_cat_dom, IPR013780:Glyco_hydro_b, IPR017853:Glycoside_hydrolase_SF 10194383 10.1021/bi982650+ 1999 ProTherm 19109 246 669 Alpha-amylase Pseudoalteromonas haloplanktis 195.0 210.0 yes 37.9 MES 30 mM NaCl 50 mM DSC Thermal 6.2 3.2.1.1 P29957 IPR006048:A-amylase/branching_C, IPR031319:A-amylase_C, IPR006046:Alpha_amylase, IPR006047:Glyco_hydro_13_cat_dom, IPR013780:Glyco_hydro_b, IPR017853:Glycoside_hydrolase_SF 10194383 10.1021/bi982650+ 1999 ProTherm 19110 246 669 Alpha-amylase Pseudoalteromonas haloplanktis 197.0 212.0 yes 39.1 MES 30 mM NaCl 50 mM DSC Thermal 6.3 3.2.1.1 P29957 IPR006048:A-amylase/branching_C, IPR031319:A-amylase_C, IPR006046:Alpha_amylase, IPR006047:Glyco_hydro_13_cat_dom, IPR013780:Glyco_hydro_b, IPR017853:Glycoside_hydrolase_SF 10194383 10.1021/bi982650+ 1999 ProTherm 19111 246 669 Alpha-amylase Pseudoalteromonas haloplanktis 223.0 231.0 yes 40.7 MES 30 mM NaCl 50 mM DSC Thermal 6.4 3.2.1.1 P29957 IPR006048:A-amylase/branching_C, IPR031319:A-amylase_C, IPR006046:Alpha_amylase, IPR006047:Glyco_hydro_13_cat_dom, IPR013780:Glyco_hydro_b, IPR017853:Glycoside_hydrolase_SF 10194383 10.1021/bi982650+ 1999 ProTherm 19112 246 669 Alpha-amylase Pseudoalteromonas haloplanktis 238.0 224.0 yes 43.7 MOPS 30 mM NaCl 50 mM DSC Thermal 7.2 3.2.1.1 P29957 IPR006048:A-amylase/branching_C, IPR031319:A-amylase_C, IPR006046:Alpha_amylase, IPR006047:Glyco_hydro_13_cat_dom, IPR013780:Glyco_hydro_b, IPR017853:Glycoside_hydrolase_SF 10194383 10.1021/bi982650+ 1999 ProTherm 22244 246 669 Alpha-amylase Pseudoalteromonas haloplanktis 214.0 203.0 yes(100 %) 44.0 MOPS 30 mM NaCl 50 mM DSC Thermal 7.2 3.2.1.1 P29957 IPR006048:A-amylase/branching_C, IPR031319:A-amylase_C, IPR006046:Alpha_amylase, IPR006047:Glyco_hydro_13_cat_dom, IPR013780:Glyco_hydro_b, IPR017853:Glycoside_hydrolase_SF 11325973 10.1074/jbc.M102741200 2001 ProTherm 22801 246 669 Alpha-amylase Pseudoalteromonas haloplanktis 214.0 yes 44.0 Mops 30 mM NaCl 50 mM DSC Thermal 7.2 3.2.1.1 P29957 IPR006048:A-amylase/branching_C, IPR031319:A-amylase_C, IPR006046:Alpha_amylase, IPR006047:Glyco_hydro_13_cat_dom, IPR013780:Glyco_hydro_b, IPR017853:Glycoside_hydrolase_SF 14499602 10.1016/j.jmb.2003.07.014 2003 ProTherm 22961 246 669 Alpha-amylase Pseudoalteromonas haloplanktis 214.0 yes 44.0 MOPS 30 mM NaCl 50 mM DSC Thermal 7.2 3.2.1.1 P29957 IPR006048:A-amylase/branching_C, IPR031319:A-amylase_C, IPR006046:Alpha_amylase, IPR006047:Glyco_hydro_13_cat_dom, IPR013780:Glyco_hydro_b, IPR017853:Glycoside_hydrolase_SF 12324460 10.1074/jbc.M207253200 2002 ProTherm 27085 246 669 Alpha-amylase Pseudoalteromonas haloplanktis 8.33 yes MOPS 30 mM 20.0 NaCl 50 mM DSC Thermal 7.2 3.2.1.1 P29957 IPR006048:A-amylase/branching_C, IPR031319:A-amylase_C, IPR006046:Alpha_amylase, IPR006047:Glyco_hydro_13_cat_dom, IPR013780:Glyco_hydro_b, IPR017853:Glycoside_hydrolase_SF 12324460 10.1074/jbc.M207253200 2002 ProTherm 411 226 669 N36R Alpha-amylase Pseudoalteromonas haloplanktis 193.0 231.0 yes(25 %) 43.3 MOPS 30 mM NaCl 50 mM DSC Thermal 7.2 3.2.1.1 P29957 IPR006048:A-amylase/branching_C, IPR031319:A-amylase_C, IPR006046:Alpha_amylase, IPR006047:Glyco_hydro_13_cat_dom, IPR013780:Glyco_hydro_b, IPR017853:Glycoside_hydrolase_SF 6.0 1AQH 15.581818320534445 in pocket 11325973 10.1074/jbc.M102741200 2001 ProTherm 15803 7409 669 Q82C, A123C Alpha-amylase Pseudoalteromonas haloplanktis 78.0 -4.0 yes 40.0 MOPS 30 mM NaCl 50 mM DSC Thermal 7.2 3.2.1.1 P29957 IPR006048:A-amylase/branching_C, IPR031319:A-amylase_C, IPR006046:Alpha_amylase, IPR006047:Glyco_hydro_13_cat_dom, IPR013780:Glyco_hydro_b, IPR017853:Glycoside_hydrolase_SF 4.0, 6.0 1AQH 24.5058331489563, 22.916666666666668 12324460 10.1074/jbc.M207253200 2002 ProTherm 15804 7409 669 Q82C, A123C Alpha-amylase Pseudoalteromonas haloplanktis 163.0 0.3 yes 44.3 MOPS 30 mM NaCl 50 mM DSC Thermal 7.2 3.2.1.1 P29957 IPR006048:A-amylase/branching_C, IPR031319:A-amylase_C, IPR006046:Alpha_amylase, IPR006047:Glyco_hydro_13_cat_dom, IPR013780:Glyco_hydro_b, IPR017853:Glycoside_hydrolase_SF 4.0, 6.0 1AQH 24.5058331489563, 22.916666666666668 12324460 10.1074/jbc.M207253200 2002 ProTherm 17300 7409 669 Q82C, A123C Alpha-amylase Pseudoalteromonas haloplanktis 3.19 yes 3.0 MOPS 30 mM 20.0 NaCl 50 mM DSC Thermal 7.2 3.2.1.1 P29957 IPR006048:A-amylase/branching_C, IPR031319:A-amylase_C, IPR006046:Alpha_amylase, IPR006047:Glyco_hydro_13_cat_dom, IPR013780:Glyco_hydro_b, IPR017853:Glycoside_hydrolase_SF 4.0, 6.0 1AQH 24.5058331489563, 22.916666666666668 12324460 10.1074/jbc.M207253200 2002 ProTherm 17301 7409 669 Q82C, A123C Alpha-amylase Pseudoalteromonas haloplanktis 7.01 yes 3.0 MOPS 30 mM 20.0 NaCl 50 mM DSC Thermal 7.2 3.2.1.1 P29957 IPR006048:A-amylase/branching_C, IPR031319:A-amylase_C, IPR006046:Alpha_amylase, IPR006047:Glyco_hydro_13_cat_dom, IPR013780:Glyco_hydro_b, IPR017853:Glycoside_hydrolase_SF 4.0, 6.0 1AQH 24.5058331489563, 22.916666666666668 12324460 10.1074/jbc.M207253200 2002 ProTherm 17302 7409 669 Q82C, A123C Alpha-amylase Pseudoalteromonas haloplanktis -1.87 10.2 yes 3.0 MOPS 30 mM 20.0 NaCl 50 mM DSC Thermal 7.2 3.2.1.1 P29957 IPR006048:A-amylase/branching_C, IPR031319:A-amylase_C, IPR006046:Alpha_amylase, IPR006047:Glyco_hydro_13_cat_dom, IPR013780:Glyco_hydro_b, IPR017853:Glycoside_hydrolase_SF 4.0, 6.0 1AQH 24.5058331489563, 22.916666666666668 12324460 10.1074/jbc.M207253200 2002 ProTherm 409 224 669 R88E Alpha-amylase Pseudoalteromonas haloplanktis 236.0 112.0 yes(96 %) 42.6 MOPS 30 mM NaCl 50 mM DSC Thermal 7.2 3.2.1.1 P29957 IPR006048:A-amylase/branching_C, IPR031319:A-amylase_C, IPR006046:Alpha_amylase, IPR006047:Glyco_hydro_13_cat_dom, IPR013780:Glyco_hydro_b, IPR017853:Glycoside_hydrolase_SF 6.0 1AQH 20.915294086231906 11325973 10.1074/jbc.M102741200 2001 ProTherm 399 218 669 N174D Alpha-amylase Pseudoalteromonas haloplanktis 271.0 240.0 yes(97 %) 44.8 MOPS 30 mM NaCl 50 mM DSC Thermal 7.2 3.2.1.1 P29957 IPR006048:A-amylase/branching_C, IPR031319:A-amylase_C, IPR006046:Alpha_amylase, IPR006047:Glyco_hydro_13_cat_dom, IPR013780:Glyco_hydro_b, IPR017853:Glycoside_hydrolase_SF 2.0 1AQH 12.98454562100497 11325973 10.1074/jbc.M102741200 2001 ProTherm 15664 7305 669 N174D, V220F Alpha-amylase Pseudoalteromonas haloplanktis 272.0 271.0 yes(91 %) 46.4 MOPS 30 mM NaCl 50 mM DSC Thermal 7.2 3.2.1.1 P29957 IPR006048:A-amylase/branching_C, IPR031319:A-amylase_C, IPR006046:Alpha_amylase, IPR006047:Glyco_hydro_13_cat_dom, IPR013780:Glyco_hydro_b, IPR017853:Glycoside_hydrolase_SF 2.0, 7.0 1AQH 12.98454562100497, 19.611250162124634 11325973 10.1074/jbc.M102741200 2001 ProTherm 15756 7369 669 K324R, N174D, V220F, Q188I, T256V Alpha-amylase Pseudoalteromonas haloplanktis 229.0 5.4 yes 49.4 Mops 30 mM NaCl 50 mM DSC Thermal 7.2 3.2.1.1 P29957 IPR006048:A-amylase/branching_C, IPR031319:A-amylase_C, IPR006046:Alpha_amylase, IPR006047:Glyco_hydro_13_cat_dom, IPR013780:Glyco_hydro_b, IPR017853:Glycoside_hydrolase_SF binding site 2.0, 6.0, 7.0, 5.0, 7.0 1AQH 12.98454562100497, 14.58916687965393, 19.611250162124634, 14.098888821072048, 12.226923062251164 in pocket 14499602 10.1016/j.jmb.2003.07.014 2003 ProTherm 15757 7369 669 K324R, N174D, V220F, Q188I, T256V Alpha-amylase Pseudoalteromonas haloplanktis 277.0 7.8 yes 51.8 Mops 30 mM NaCl 50 mM DSC Thermal 7.2 3.2.1.1 P29957 IPR006048:A-amylase/branching_C, IPR031319:A-amylase_C, IPR006046:Alpha_amylase, IPR006047:Glyco_hydro_13_cat_dom, IPR013780:Glyco_hydro_b, IPR017853:Glycoside_hydrolase_SF binding site 2.0, 6.0, 7.0, 5.0, 7.0 1AQH 12.98454562100497, 14.58916687965393, 19.611250162124634, 14.098888821072048, 12.226923062251164 in pocket 14499602 10.1016/j.jmb.2003.07.014 2003 ProTherm 401 220 669 Q188I Alpha-amylase Pseudoalteromonas haloplanktis 87.0 117.0 yes(64 %) 3.0 42.7 MOPS 30 mM NaCl 50 mM DSC Thermal 7.2 3.2.1.1 P29957 IPR006048:A-amylase/branching_C, IPR031319:A-amylase_C, IPR006046:Alpha_amylase, IPR006047:Glyco_hydro_13_cat_dom, IPR013780:Glyco_hydro_b, IPR017853:Glycoside_hydrolase_SF 6.0 1AQH 14.58916687965393 11325973 10.1074/jbc.M102741200 2001 ProTherm 402 220 669 Q188I Alpha-amylase Pseudoalteromonas haloplanktis 117.0 240.0 yes(64 %) 3.0 45.2 MOPS 30 mM NaCl 50 mM DSC Thermal 7.2 3.2.1.1 P29957 IPR006048:A-amylase/branching_C, IPR031319:A-amylase_C, IPR006046:Alpha_amylase, IPR006047:Glyco_hydro_13_cat_dom, IPR013780:Glyco_hydro_b, IPR017853:Glycoside_hydrolase_SF 6.0 1AQH 14.58916687965393 11325973 10.1074/jbc.M102741200 2001 ProTherm 15665 7306 669 Q188I, V220F Alpha-amylase Pseudoalteromonas haloplanktis 83.0 121.0 yes(51 %) 3.0 44.7 MOPS 30 mM NaCl 50 mM DSC Thermal 7.2 3.2.1.1 P29957 IPR006048:A-amylase/branching_C, IPR031319:A-amylase_C, IPR006046:Alpha_amylase, IPR006047:Glyco_hydro_13_cat_dom, IPR013780:Glyco_hydro_b, IPR017853:Glycoside_hydrolase_SF 6.0, 7.0 1AQH 14.58916687965393, 19.611250162124634 11325973 10.1074/jbc.M102741200 2001 ProTherm 15666 7306 669 Q188I, V220F Alpha-amylase Pseudoalteromonas haloplanktis 125.0 308.0 yes(51 %) 3.0 46.2 MOPS 30 mM NaCl 50 mM DSC Thermal 7.2 3.2.1.1 P29957 IPR006048:A-amylase/branching_C, IPR031319:A-amylase_C, IPR006046:Alpha_amylase, IPR006047:Glyco_hydro_13_cat_dom, IPR013780:Glyco_hydro_b, IPR017853:Glycoside_hydrolase_SF 6.0, 7.0 1AQH 14.58916687965393, 19.611250162124634 11325973 10.1074/jbc.M102741200 2001 ProTherm 400 219 669 V220F Alpha-amylase Pseudoalteromonas haloplanktis 234.0 296.0 yes(60 %) 45.4 MOPS 30 mM NaCl 50 mM DSC Thermal 7.2 3.2.1.1 P29957 IPR006048:A-amylase/branching_C, IPR031319:A-amylase_C, IPR006046:Alpha_amylase, IPR006047:Glyco_hydro_13_cat_dom, IPR013780:Glyco_hydro_b, IPR017853:Glycoside_hydrolase_SF 7.0 1AQH 19.611250162124634 11325973 10.1074/jbc.M102741200 2001 ProTherm 410 225 669 L243R Alpha-amylase Pseudoalteromonas haloplanktis 217.0 187.0 yes(81 %) 42.5 MOPS 30 mM NaCl 50 mM DSC Thermal 7.2 3.2.1.1 P29957 IPR006048:A-amylase/branching_C, IPR031319:A-amylase_C, IPR006046:Alpha_amylase, IPR006047:Glyco_hydro_13_cat_dom, IPR013780:Glyco_hydro_b, IPR017853:Glycoside_hydrolase_SF 6.0 1AQH 15.766666730244955 11325973 10.1074/jbc.M102741200 2001 ProTherm 403 221 669 T256V Alpha-amylase Pseudoalteromonas haloplanktis 102.0 114.0 yes(85 %) 3.0 42.7 MOPS 30 mM NaCl 50 mM DSC Thermal 7.2 3.2.1.1 P29957 IPR006048:A-amylase/branching_C, IPR031319:A-amylase_C, IPR006046:Alpha_amylase, IPR006047:Glyco_hydro_13_cat_dom, IPR013780:Glyco_hydro_b, IPR017853:Glycoside_hydrolase_SF 5.0 1AQH 14.098888821072048 11325973 10.1074/jbc.M102741200 2001 ProTherm 404 221 669 T256V Alpha-amylase Pseudoalteromonas haloplanktis 104.0 202.0 yes(85 %) 3.0 45.7 MOPS 30 mM NaCl 50 mM DSC Thermal 7.2 3.2.1.1 P29957 IPR006048:A-amylase/branching_C, IPR031319:A-amylase_C, IPR006046:Alpha_amylase, IPR006047:Glyco_hydro_13_cat_dom, IPR013780:Glyco_hydro_b, IPR017853:Glycoside_hydrolase_SF 5.0 1AQH 14.098888821072048 11325973 10.1074/jbc.M102741200 2001 ProTherm 412 227 669 E303W Alpha-amylase Pseudoalteromonas haloplanktis 186.0 234.0 yes(76 %) 41.4 MOPS 30 mM NaCl 50 mM DSC Thermal 7.2 3.2.1.1 P29957 IPR006048:A-amylase/branching_C, IPR031319:A-amylase_C, IPR006046:Alpha_amylase, IPR006047:Glyco_hydro_13_cat_dom, IPR013780:Glyco_hydro_b, IPR017853:Glycoside_hydrolase_SF 5.0 1AQH 25.87300024032593 11325973 10.1074/jbc.M102741200 2001 ProTherm 405 222 669 N312V Alpha-amylase Pseudoalteromonas haloplanktis 88.0 133.0 yes(30 %) 3.0 38.1 MOPS 30 mM NaCl 50 mM DSC Thermal 7.2 3.2.1.1 P29957 IPR006048:A-amylase/branching_C, IPR031319:A-amylase_C, IPR006046:Alpha_amylase, IPR006047:Glyco_hydro_13_cat_dom, IPR013780:Glyco_hydro_b, IPR017853:Glycoside_hydrolase_SF 5.0 1AQH 9.05181832747026 in pocket 11325973 10.1074/jbc.M102741200 2001 ProTherm 406 222 669 N312V Alpha-amylase Pseudoalteromonas haloplanktis 59.0 114.0 yes(30 %) 3.0 45.9 MOPS 30 mM NaCl 50 mM DSC Thermal 7.2 3.2.1.1 P29957 IPR006048:A-amylase/branching_C, IPR031319:A-amylase_C, IPR006046:Alpha_amylase, IPR006047:Glyco_hydro_13_cat_dom, IPR013780:Glyco_hydro_b, IPR017853:Glycoside_hydrolase_SF 5.0 1AQH 9.05181832747026 in pocket 11325973 10.1074/jbc.M102741200 2001 ProTherm 398 217 669 K324R Alpha-amylase Pseudoalteromonas haloplanktis 223.0 217.0 yes(87 %) 45.2 MOPS 30 mM NaCl 50 mM DSC Thermal 7.2 3.2.1.1 P29957 IPR006048:A-amylase/branching_C, IPR031319:A-amylase_C, IPR006046:Alpha_amylase, IPR006047:Glyco_hydro_13_cat_dom, IPR013780:Glyco_hydro_b, IPR017853:Glycoside_hydrolase_SF binding site 7.0 1AQH 12.226923062251164 in pocket 11325973 10.1074/jbc.M102741200 2001 ProTherm 407 223 669 M403V Alpha-amylase Pseudoalteromonas haloplanktis 127.0 96.0 yes(95 %) 3.0 42.6 MOPS 30 mM NaCl 50 mM DSC Thermal 7.2 3.2.1.1 P29957 IPR006048:A-amylase/branching_C, IPR031319:A-amylase_C, IPR006046:Alpha_amylase, IPR006047:Glyco_hydro_13_cat_dom, IPR013780:Glyco_hydro_b, IPR017853:Glycoside_hydrolase_SF 7.0 1AQH 12.292222128974068 in pocket 11325973 10.1074/jbc.M102741200 2001 ProTherm 408 223 669 M403V Alpha-amylase Pseudoalteromonas haloplanktis 84.0 137.0 yes(95 %) 3.0 47.7 MOPS 30 mM NaCl 50 mM DSC Thermal 7.2 3.2.1.1 P29957 IPR006048:A-amylase/branching_C, IPR031319:A-amylase_C, IPR006046:Alpha_amylase, IPR006047:Glyco_hydro_13_cat_dom, IPR013780:Glyco_hydro_b, IPR017853:Glycoside_hydrolase_SF 7.0 1AQH 12.292222128974068 in pocket 11325973 10.1074/jbc.M102741200 2001 ProTherm 19394 270 2477 Fibronectin Homo sapiens 112.0 81.0 yes 60.9 Tris 0.02 M NaCl 0.15 M DSC Thermal 9.5 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 1994038 10.1016/0022-2836(91)90758-x 1991 ProTherm 19395 270 2477 Fibronectin Homo sapiens 130.0 74.0 yes 64.1 Tris 0.02 M NaCl 0.15 M DSC Thermal 8.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 1994038 10.1016/0022-2836(91)90758-x 1991 ProTherm 19396 270 2477 Fibronectin Homo sapiens 127.0 79.0 yes 64.4 Tris 0.02 M NaCl 0.15 M DSC Thermal 7.4 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 1994038 10.1016/0022-2836(91)90758-x 1991 ProTherm 19397 270 2477 Fibronectin Homo sapiens 89.0 75.0 yes 56.0 acetate 0.01 M NaCl 0.15 M DSC Thermal 4.1 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 1994038 10.1016/0022-2836(91)90758-x 1991 ProTherm 19398 270 2477 Fibronectin Homo sapiens 82.0 63.0 yes 51.8 glycine 0.05 M DSC Thermal 3.4 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 1994038 10.1016/0022-2836(91)90758-x 1991 ProTherm 19399 270 2477 Fibronectin Homo sapiens 69.0 53.0 yes 37.5 glycine 0.05 M DSC Thermal 2.5 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 1994038 10.1016/0022-2836(91)90758-x 1991 ProTherm 19400 270 2477 Fibronectin Homo sapiens 62.0 50.0 yes 37.3 H3PO4 0.01 M NaCl 0.15 M DSC Thermal 2.5 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 1994038 10.1016/0022-2836(91)90758-x 1991 ProTherm 19515 270 2477 Fibronectin Homo sapiens 58.56 yes 74.8 glycine 50 mM DSC Thermal 4.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 2299666 10.1016/0022-2836(90)90018-H 1990 ProTherm 19516 270 2477 Fibronectin Homo sapiens 46.61 yes 73.1 glycine 50 mM DSC Thermal 4.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 2299666 10.1016/0022-2836(90)90018-H 1990 ProTherm 19517 270 2477 Fibronectin Homo sapiens 41.83 yes 64.0 glycine 50 mM DSC Thermal 7.4 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 2299666 10.1016/0022-2836(90)90018-H 1990 ProTherm 19518 270 2477 Fibronectin Homo sapiens 83.65 yes 60.7 glycine 50 mM DSC Thermal 4.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 2299666 10.1016/0022-2836(90)90018-H 1990 ProTherm 19519 270 2477 Fibronectin Homo sapiens 131.45 yes 63.0 glycine 50 mM DSC Thermal 8.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 2299666 10.1016/0022-2836(90)90018-H 1990 ProTherm 19520 270 2477 Fibronectin Homo sapiens 71.7 yes 86.0 glycine 50 mM DSC Thermal 8.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 2299666 10.1016/0022-2836(90)90018-H 1990 ProTherm 19521 270 2477 Fibronectin Homo sapiens 69.31 yes 62.0 glycine 50 mM DSC Thermal 8.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 2299666 10.1016/0022-2836(90)90018-H 1990 ProTherm 19522 270 2477 Fibronectin Homo sapiens 62.14 yes 66.0 glycine 50 mM DSC Thermal 8.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 2299666 10.1016/0022-2836(90)90018-H 1990 ProTherm 19523 270 2477 Fibronectin Homo sapiens 47.8 yes 70.0 glycine 50 mM DSC Thermal 4.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 2299666 10.1016/0022-2836(90)90018-H 1990 ProTherm 19524 270 2477 Fibronectin Homo sapiens 74.09 yes 56.0 glycine 50 mM DSC Thermal 8.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 2299666 10.1016/0022-2836(90)90018-H 1990 ProTherm 19525 270 2477 Fibronectin Homo sapiens 88.43 yes 60.0 glycine 50 mM DSC Thermal 8.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 2299666 10.1016/0022-2836(90)90018-H 1990 ProTherm 19526 270 2477 Fibronectin Homo sapiens 92.02 yes 90.0 glycine 50 mM DSC Thermal 8.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 2299666 10.1016/0022-2836(90)90018-H 1990 ProTherm 19858 270 2477 Fibronectin Homo sapiens yes 55.0 Sodium acetate 50 mM Fluorescence Thermal 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 9245604 10.1006/jmbi.1997.1147 1997 ProTherm 19859 270 2477 Fibronectin Homo sapiens yes 44.0 Sodium phosphate 50 mM CD Thermal 7.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 9245604 10.1006/jmbi.1997.1147 1997 ProTherm 21311 270 2477 Fibronectin Homo sapiens 1.47 9.38 6.38 yes Sodium acetate 50 mM 25.0 CD GdnSCN 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 10739253 10.1110/ps.9.1.112 2000 ProTherm 21319 270 2477 Fibronectin Homo sapiens 1.49 9.4 6.4 2.0 Sodium acetate 50mM 25.0 Fluorescence GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 10986129 10.1006/jmbi.2000.4053 2000 ProTherm 21803 270 2477 Fibronectin Homo sapiens 3.9 4.3 1.1 yes Sodium acetate 50 mM 20.0 Fluorescence Urea 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 9245604 10.1006/jmbi.1997.1147 1997 ProTherm 21804 270 2477 Fibronectin Homo sapiens 3.7 5.2 1.4 yes Sodium acetate 50 mM 20.0 Fluorescence Urea 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 9245604 10.1006/jmbi.1997.1147 1997 ProTherm 21805 270 2477 Fibronectin Homo sapiens 2.5 2.8 1.1 yes Sodium phosphate 50 mM 20.0 Fluorescence Urea 7.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 9245604 10.1006/jmbi.1997.1147 1997 ProTherm 21806 270 2477 Fibronectin Homo sapiens 2.4 2.9 1.2 yes Sodium phosphate 50 mM 20.0 Fluorescence Urea 7.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 9245604 10.1006/jmbi.1997.1147 1997 ProTherm 21807 270 2477 Fibronectin Homo sapiens 2.3 3.2 1.4 yes Sodium phosphate 50 mM 20.0 CD Urea 7.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 9245604 10.1006/jmbi.1997.1147 1997 ProTherm 22271 270 2477 Fibronectin Homo sapiens yes 72.0 glycine hydrochloride 20 mM NaCl 0.1 M CD Thermal 2.4 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 11513611 10.1021/bi010916y 2001 ProTherm 22272 270 2477 Fibronectin Homo sapiens yes 82.0 glycine hydrochloride 20 mM NaCl 1 M CD Thermal 2.4 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 11513611 10.1021/bi010916y 2001 ProTherm 22273 270 2477 Fibronectin Homo sapiens yes 62.0 sodium phosphate 20 mM NaCl 0.1 M CD Thermal 7.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 11513611 10.1021/bi010916y 2001 ProTherm 22274 270 2477 Fibronectin Homo sapiens yes 70.0 sodium phosphate 20 mM NaCl 1 M CD Thermal 7.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 11513611 10.1021/bi010916y 2001 ProTherm 24623 270 2477 Fibronectin Homo sapiens 9.38 yes 2.0 82.5 CD Thermal 7.4 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 25691761 10.1093/protein/gzv002 2015 ProTherm 24624 270 2477 Fibronectin Homo sapiens yes 2.0 58.0 CD Thermal 7.4 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 25691761 10.1093/protein/gzv002 2015 ProTherm 25480 270 2477 Fibronectin Homo sapiens 7.7 2.4 Unknown sodium acetate 30.0 NaCl 100 mM Fluorescence GdnHCl 5.5 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 17322532 10.1110/ps.062498407 2007 ProTherm 25481 270 2477 Fibronectin Homo sapiens 7.4 1.6 Unknown sodium acetate 30.0 NaCl 100 mM Fluorescence GdnHCl 5.5 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 17322532 10.1110/ps.062498407 2007 ProTherm 25482 270 2477 Fibronectin Homo sapiens 7.2 1.6 Unknown sodium acetate 30.0 NaCl 100 mM Fluorescence GdnHCl 5.5 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 17322532 10.1110/ps.062498407 2007 ProTherm 25483 270 2477 Fibronectin Homo sapiens 7.1 1.6 Unknown sodium acetate 30.0 NaCl 100 mM Fluorescence GdnHCl 5.5 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 17322532 10.1110/ps.062498407 2007 ProTherm 25484 270 2477 Fibronectin Homo sapiens 5.2 1.6 Unknown sodium acetate 30.0 NaCl 100 mM Fluorescence GdnHCl 5.5 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 17322532 10.1110/ps.062498407 2007 ProTherm 25485 270 2477 Fibronectin Homo sapiens 4.1 2.0 Unknown sodium acetate 30.0 NaCl 100 mM Fluorescence GdnHCl 5.5 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 17322532 10.1110/ps.062498407 2007 ProTherm 25489 270 2477 Fibronectin Homo sapiens 2.0 Sodium citrate 20mM 30.0 NaCl 100mM Fluorescence GdnSCN 6.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 18674545 10.1016/j.jmb.2008.07.036 2008 ProTherm 26657 270 2477 Fibronectin Homo sapiens 7.5 2.0 Sodium acetate 50mM 25.0 Fluorescence GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 18035373 10.1016/j.jmb.2007.10.056 2008 ProTherm 26681 270 2477 Fibronectin Homo sapiens 5.7 6.1 ?1.06 yes 2.0 PBS 25.0 KH2PO4,NaCl,KCl,NaH2PO4 1.4mM, 0.14M, 2.5mM, 5mM Trp Fluorescence Urea 7.2 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 27909052 10.1074/jbc.M116.760371 2017 ProTherm 26682 270 2477 Fibronectin Homo sapiens 5.6 5.9 ?1.05 yes 2.0 Phosphate buffer 50mM 25.0 KH2PO4,K2HPO4 14mM, 37.3mM SX (thiol exchange) Urea 7.5 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 27909052 10.1074/jbc.M116.760371 2017 ProTherm 26683 270 2477 Fibronectin Homo sapiens 5.8 4.7 ?0.81 yes 2.0 PBS 25.0 KH2PO4,NaCl,KCl,NaH2PO4 1.4mM, 0.14M, 2.5mM, 5mM Trp Fluorescence Urea 7.2 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 27909052 10.1074/jbc.M116.760371 2017 ProTherm 26684 270 2477 Fibronectin Homo sapiens 2.5 3.4 ?1.39 yes 2.0 Phosphate buffer 50mM 25.0 KH2PO4,K2HPO4 14mM, 37.3mM SX (thiol exchange) Urea 7.5 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 27909052 10.1074/jbc.M116.760371 2017 ProTherm 26685 270 2477 Fibronectin Homo sapiens 2.8 3.3 ?1.16 yes 2.0 PBS 25.0 KH2PO4,NaCl,KCl,NaH2PO4 1.4mM, 0.14M, 2.5mM, 5mM Trp Fluorescence Urea 7.2 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 27909052 10.1074/jbc.M116.760371 2017 ProTherm 26686 270 2477 Fibronectin Homo sapiens 3.4 3.8 ?1.15 yes 2.0 PBS 25.0 KH2PO4,NaCl,KCl,NaH2PO4 1.4mM, 0.14M, 2.5mM, 5mM Trp (SVD) Urea 7.2 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 27909052 10.1074/jbc.M116.760371 2017 ProTherm 26687 270 2477 Fibronectin Homo sapiens 5.4 5.6 ?1.03 yes 2.0 Phosphate buffer 50mM 25.0 KH2PO4,K2HPO4 14mM, 37.3mM SX (thiol exchange) Urea 7.5 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 27909052 10.1074/jbc.M116.760371 2017 ProTherm 26688 270 2477 Fibronectin Homo sapiens 6.7 3.4 ?0.51 yes 2.0 PBS 25.0 KH2PO4,NaCl,KCl,NaH2PO4 1.4mM, 0.14M, 2.5mM, 5mM Trp Fluorescence Urea 7.2 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 27909052 10.1074/jbc.M116.760371 2017 ProTherm 26689 270 2477 Fibronectin Homo sapiens 4.6 5.9 ?1.3 yes 2.0 Phosphate buffer 50mM 25.0 KH2PO4,K2HPO4 14mM, 37.3mM SX (thiol exchange) Urea 7.5 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 27909052 10.1074/jbc.M116.760371 2017 ProTherm 26690 270 2477 Fibronectin Homo sapiens 3.6 3.7 ?1.0 yes 2.0 Phosphate buffer 50mM 25.0 KH2PO4,K2HPO4 14mM, 37.3mM SX (thiol exchange) Urea 7.5 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 27909052 10.1074/jbc.M116.760371 2017 ProTherm 26691 270 2477 Fibronectin Homo sapiens 3.4 3.0 ?0.87 yes 2.0 PBS 25.0 KH2PO4,NaCl,KCl,NaH2PO4 1.4mM, 0.14M, 2.5mM, 5mM Trp Fluorescence Urea 7.2 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 27909052 10.1074/jbc.M116.760371 2017 ProTherm 26692 270 2477 Fibronectin Homo sapiens 8.8 8.2 -0.93 yes 2.0 Phosphate buffer 50mM 25.0 KH2PO4,K2HPO4 14mM, 37.3mM SX (thiol exchange) Urea 7.5 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 27909052 10.1074/jbc.M116.760371 2017 ProTherm 26693 270 2477 Fibronectin Homo sapiens 8.8 10.6 ?1.21 yes 2.0 PBS 25.0 KH2PO4,NaCl,KCl,NaH2PO4 1.4mM, 0.14M, 2.5mM, 5mM Trp Fluorescence Urea 7.2 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 27909052 10.1074/jbc.M116.760371 2017 ProTherm 26694 270 2477 Fibronectin Homo sapiens 0.48 0.78 ?1.64 yes 2.0 Phosphate buffer 50mM 25.0 KH2PO4,K2HPO4 14mM, 37.3mM SX (thiol exchange) Urea 7.5 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 27909052 10.1074/jbc.M116.760371 2017 ProTherm 26695 270 2477 Fibronectin Homo sapiens 0.88 1.6 ?1.79 yes 2.0 PBS 25.0 KH2PO4,NaCl,KCl,NaH2PO4 1.4mM, 0.14M, 2.5mM, 5mM Trp Fluorescence Urea 7.2 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 27909052 10.1074/jbc.M116.760371 2017 ProTherm 26696 270 2477 Fibronectin Homo sapiens 2.96 4.3 ?1.45 yes 2.0 Phosphate buffer 50mM 25.0 KH2PO4,K2HPO4 14mM, 37.3mM SX (thiol exchange) Urea 7.5 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 27909052 10.1074/jbc.M116.760371 2017 ProTherm 26697 270 2477 Fibronectin Homo sapiens 3.7 5.4 ?1.47 yes 2.0 PBS 25.0 KH2PO4,NaCl,KCl,NaH2PO4 1.4mM, 0.14M, 2.5mM, 5mM Trp Fluorescence Urea 7.2 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 27909052 10.1074/jbc.M116.760371 2017 ProTherm 26698 270 2477 Fibronectin Homo sapiens 2.9 4.1 ?1.42 yes 2.0 Phosphate buffer 50mM 25.0 KH2PO4,K2HPO4 14mM, 37.3mM SX (thiol exchange) Urea 7.5 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 27909052 10.1074/jbc.M116.760371 2017 ProTherm 26699 270 2477 Fibronectin Homo sapiens 2.4 3.4 ?1.41 yes 2.0 PBS 25.0 KH2PO4,NaCl,KCl,NaH2PO4 1.4mM, 0.14M, 2.5mM, 5mM Trp Fluorescence Urea 7.2 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 27909052 10.1074/jbc.M116.760371 2017 ProTherm 26700 270 2477 Fibronectin Homo sapiens 1.9 2.9 ?1.51 yes 2.0 Phosphate buffer 50mM 25.0 KH2PO4,K2HPO4 14mM, 37.3mM SX (thiol exchange) Urea 7.5 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 27909052 10.1074/jbc.M116.760371 2017 ProTherm 26701 270 2477 Fibronectin Homo sapiens 3.9 2.5 ?0.65 yes 2.0 PBS 25.0 KH2PO4,NaCl,KCl,NaH2PO4 1.4mM, 0.14M, 2.5mM, 5mM Trp Fluorescence Urea 7.2 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 27909052 10.1074/jbc.M116.760371 2017 ProTherm 26839 270 2477 Fibronectin Homo sapiens 10.5 4.8 Unknown 4.0 Tris-HCl 1 mM 24.0 Fluorescence Urea 7.4 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 14769050 10.1021/bi0347104 2004 ProTherm 26840 270 2477 Fibronectin Homo sapiens 9.9 3.6 Unknown 4.0 Tris-HCl 1 mM 24.0 Fluorescence Urea 7.4 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 14769050 10.1021/bi0347104 2004 ProTherm 26841 270 2477 Fibronectin Homo sapiens 10.6 4.4 Unknown 4.0 Tris-HCl 10 mM 24.0 Fluorescence Urea 7.4 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 14769050 10.1021/bi0347104 2004 ProTherm 26842 270 2477 Fibronectin Homo sapiens 10.8 5.0 Unknown 4.0 Tris-HCl 10 mM 24.0 NaCl 30 mM Fluorescence Urea 7.4 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 14769050 10.1021/bi0347104 2004 ProTherm 26843 270 2477 Fibronectin Homo sapiens 10.7 5.1 Unknown 4.0 Tris-HCl 10 mM 24.0 NaCl 150 mM Fluorescence Urea 7.4 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 14769050 10.1021/bi0347104 2004 ProTherm 26844 270 2477 Fibronectin Homo sapiens 8.6 1.8 Unknown 4.0 24.0 Fluorescence Urea 7.4 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 14769050 10.1021/bi0347104 2004 ProTherm 26845 270 2477 Fibronectin Homo sapiens 6.6 1.2 Unknown 4.0 Tris-HCl 1 mM 24.0 Fluorescence Urea 7.4 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 14769050 10.1021/bi0347104 2004 ProTherm 26846 270 2477 Fibronectin Homo sapiens 4.5 1.0 Unknown 4.0 Tris-HCl 10 mM 24.0 Fluorescence Urea 7.4 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 14769050 10.1021/bi0347104 2004 ProTherm 26847 270 2477 Fibronectin Homo sapiens 4.2 1.0 Unknown 4.0 Tris-HCl 10 mM 24.0 NaCl 30 mM Fluorescence Urea 7.4 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 14769050 10.1021/bi0347104 2004 ProTherm 26848 270 2477 Fibronectin Homo sapiens 4.2 1.0 Unknown 4.0 Tris-HCl 10 mM 24.0 NaCl 150 mM Fluorescence Urea 7.4 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 14769050 10.1021/bi0347104 2004 ProTherm 26849 270 2477 Fibronectin Homo sapiens 15.0 1.8 Unknown 4.0 24.0 Fluorescence Urea 7.4 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 14769050 10.1021/bi0347104 2004 ProTherm 26850 270 2477 Fibronectin Homo sapiens 13.7 1.8 Unknown 4.0 Tris-HCl 1 mM 24.0 Fluorescence Urea 7.4 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 14769050 10.1021/bi0347104 2004 ProTherm 26851 270 2477 Fibronectin Homo sapiens 7.4 1.2 Unknown 4.0 Tris-HCl 10 mM 24.0 Fluorescence Urea 7.4 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 14769050 10.1021/bi0347104 2004 ProTherm 26852 270 2477 Fibronectin Homo sapiens 7.4 1.1 Unknown 4.0 Tris-HCl 10 mM 24.0 NaCl 30 mM Fluorescence Urea 7.4 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 14769050 10.1021/bi0347104 2004 ProTherm 26853 270 2477 Fibronectin Homo sapiens 7.3 1.1 Unknown 4.0 Tris-HCl 10 mM 24.0 NaCl 150 mM Fluorescence Urea 7.4 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 14769050 10.1021/bi0347104 2004 ProTherm 11156 4736 2477 P1542A Fibronectin Homo sapiens 1.49 -0.11 6.4 Unknown Sodium acetate 50 mM 25.0 CD GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 8.0 1TTF, 2CK2, 1FNF, 1TTG 24.584286008562362, 23.640000207083567, 27.36000006539481 in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 12463 4736 2477 P1542A Fibronectin Homo sapiens -0.21 2.0 Sodium acetate 50mM 25.0 Fluorescence GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 8.0 1TTF, 2CK2, 1FNF, 1TTG 24.584286008562362, 23.640000207083567, 27.36000006539481 in pocket 18035373 10.1016/j.jmb.2007.10.056 2008 ProTherm 427 240 2477 D1544N Fibronectin Homo sapiens yes 68.0 glycine hydrochloride 20 mM NaCl 0.1 M CD Thermal 2.4 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 9.0 1TTF, 2CK2, 1FNF, 1TTG 27.53375005722046, 29.880000114440918, 39.73888863457574 in pocket 11513611 10.1021/bi010916y 2001 ProTherm 429 240 2477 D1544N Fibronectin Homo sapiens yes 82.0 glycine hydrochloride 20 mM NaCl 1 M CD Thermal 2.4 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 9.0 1TTF, 2CK2, 1FNF, 1TTG 27.53375005722046, 29.880000114440918, 39.73888863457574 in pocket 11513611 10.1021/bi010916y 2001 ProTherm 431 240 2477 D1544N Fibronectin Homo sapiens yes 69.0 sodium phosphate 20 mM NaCl 0.1 M CD Thermal 7.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 9.0 1TTF, 2CK2, 1FNF, 1TTG 27.53375005722046, 29.880000114440918, 39.73888863457574 in pocket 11513611 10.1021/bi010916y 2001 ProTherm 433 240 2477 D1544N Fibronectin Homo sapiens yes 80.0 sodium phosphate 20 mM NaCl 1 M CD Thermal 7.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 9.0 1TTF, 2CK2, 1FNF, 1TTG 27.53375005722046, 29.880000114440918, 39.73888863457574 in pocket 11513611 10.1021/bi010916y 2001 ProTherm 428 241 2477 D1544K Fibronectin Homo sapiens yes 69.0 glycine hydrochloride 20 mM NaCl 0.1 M CD Thermal 2.4 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 9.0 1TTF, 2CK2, 1FNF, 1TTG 27.53375005722046, 29.880000114440918, 39.73888863457574 in pocket 11513611 10.1021/bi010916y 2001 ProTherm 430 241 2477 D1544K Fibronectin Homo sapiens yes 77.0 glycine hydrochloride 20 mM NaCl 1 M CD Thermal 2.4 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 9.0 1TTF, 2CK2, 1FNF, 1TTG 27.53375005722046, 29.880000114440918, 39.73888863457574 in pocket 11513611 10.1021/bi010916y 2001 ProTherm 432 241 2477 D1544K Fibronectin Homo sapiens yes 70.0 sodium phosphate 20 mM NaCl 0.1 M CD Thermal 7.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 9.0 1TTF, 2CK2, 1FNF, 1TTG 27.53375005722046, 29.880000114440918, 39.73888863457574 in pocket 11513611 10.1021/bi010916y 2001 ProTherm 434 241 2477 D1544K Fibronectin Homo sapiens yes 78.0 sodium phosphate 20 mM NaCl 1 M CD Thermal 7.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 9.0 1TTF, 2CK2, 1FNF, 1TTG 27.53375005722046, 29.880000114440918, 39.73888863457574 in pocket 11513611 10.1021/bi010916y 2001 ProTherm 11157 4737 2477 L1545A Fibronectin Homo sapiens 1.22 1.64 6.2 Unknown Sodium acetate 50 mM 25.0 CD GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 9.0 1TTF, 2CK2, 1FNF, 1TTG 19.544999837875366, 21.91374945640564, 31.333333757188583 in tunnel in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm SAAFEC_S1262.csv 11158 4738 2477 V1547A Fibronectin Homo sapiens 1.26 1.38 6.8 Unknown Sodium acetate 50 mM 25.0 CD GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 8.0 1TTF, 2CK2, 1FNF, 1TTG 16.858571325029647, 16.00857162475586, 31.005000114440918 in tunnel in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm SAAFEC_S1262.csv 11159 4739 2477 A1550G Fibronectin Homo sapiens 1.33 0.93 6.1 Unknown Sodium acetate 50 mM 25.0 CD GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 5.0 1TTF, 2CK2, 1FNF, 1TTG 21.045714242117747, 22.977142878941127, 52.375 in tunnel in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm SAAFEC_S1262.csv 11160 4740 2477 L1555A Fibronectin Homo sapiens 1.34 0.87 6.3 Unknown Sodium acetate 50 mM 25.0 CD GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 6.0 1TTF, 2CK2, 1FNF, 1TTG 15.239999961853027, 17.62800006866455, 36.09999974568685 in tunnel in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm SAAFEC_S1262.csv 11161 4741 2477 I1557A Fibronectin Homo sapiens 1.36 0.74 6.6 Unknown Sodium acetate 50 mM 25.0 CD GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 5.0 1TTF, 2CK2, 1FNF, 1TTG 15.84375011920929, 13.40625011920929, 23.608889049953884 in tunnel in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm SAAFEC_S1262.csv 12465 4741 2477 I1557A Fibronectin Homo sapiens -3.74 2.0 Sodium acetate 50mM 25.0 Fluorescence GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 5.0 1TTF, 2CK2, 1FNF, 1TTG 15.84375011920929, 13.40625011920929, 23.608889049953884 in tunnel in pocket 18035373 10.1016/j.jmb.2007.10.056 2008 ProTherm 11162 4742 2477 I1557V Fibronectin Homo sapiens 1.41 0.41 6.8 Unknown Sodium acetate 50 mM 25.0 CD GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 5.0 1TTF, 2CK2, 1FNF, 1TTG 15.84375011920929, 13.40625011920929, 23.608889049953884 in tunnel in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 12464 4742 2477 I1557V Fibronectin Homo sapiens -0.83 2.0 Sodium acetate 50mM 25.0 Fluorescence GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 5.0 1TTF, 2CK2, 1FNF, 1TTG 15.84375011920929, 13.40625011920929, 23.608889049953884 in tunnel in pocket 18035373 10.1016/j.jmb.2007.10.056 2008 ProTherm 11163 4743 2477 W1559F Fibronectin Homo sapiens 1.18 1.94 6.4 Unknown Sodium acetate 50 mM 25.0 CD GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 8.0 1TTF, 2CK2, 1FNF, 1TTG 20.71214267185756, 16.489285673413956, 19.9787500500679 in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm SAAFEC_S1262.csv 11164 4744 2477 P1562A Fibronectin Homo sapiens 1.4 0.48 6.5 Unknown Sodium acetate 50 mM 25.0 CD GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 9.0 1TTF, 2CK2, 1FNF, 1TTG 29.02142878941127, 22.15285737173898, 27.367142541067942 in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 12466 4744 2477 P1562A Fibronectin Homo sapiens -0.1 2.0 Sodium acetate 50mM 25.0 Fluorescence GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 9.0 1TTF, 2CK2, 1FNF, 1TTG 29.02142878941127, 22.15285737173898, 27.367142541067942 in pocket 18035373 10.1016/j.jmb.2007.10.056 2008 ProTherm 11165 4745 2477 V1566A Fibronectin Homo sapiens 1.25 1.45 6.6 Unknown Sodium acetate 50 mM 25.0 CD GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 9.0 1TTF, 2CK2, 1FNF, 1TTG 26.87374997138977, 24.791249990463257, 20.83999991416931 in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm SAAFEC_S1262.csv 11166 4746 2477 Y1569F Fibronectin Homo sapiens 1.41 0.41 6.3 Unknown Sodium acetate 50 mM 25.0 CD GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 9.0 1TTF, 2CK2, 1FNF, 1TTG 16.25250005722046, 21.66249966621399, 15.653571333203997 in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 11167 4747 2477 Y1569L Fibronectin Homo sapiens 1.04 2.81 6.6 Unknown Sodium acetate 50 mM 25.0 CD GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 9.0 1TTF, 2CK2, 1FNF, 1TTG 16.25250005722046, 21.66249966621399, 15.653571333203997 in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm 11170 4747 2477 Y1569L Fibronectin Homo sapiens 2.4 Unknown Sodium acetate 50 mM 25.0 CD GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 9.0 1TTF, 2CK2, 1FNF, 1TTG 16.25250005722046, 21.66249966621399, 15.653571333203997 in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm 11168 4748 2477 Y1569A Fibronectin Homo sapiens 0.8 4.37 6.8 Unknown Sodium acetate 50 mM 25.0 CD GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 9.0 1TTF, 2CK2, 1FNF, 1TTG 16.25250005722046, 21.66249966621399, 15.653571333203997 in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm 11169 4748 2477 Y1569A Fibronectin Homo sapiens 3.96 Unknown Sodium acetate 50 mM 25.0 CD GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 9.0 1TTF, 2CK2, 1FNF, 1TTG 16.25250005722046, 21.66249966621399, 15.653571333203997 in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm 11171 4749 2477 I1571A Fibronectin Homo sapiens 0.7 5.02 6.9 Unknown Sodium acetate 50 mM 25.0 CD GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 9.0 1TTF, 2CK2, 1FNF, 1TTG 14.207499980926514, 17.759999990463257, 20.274444368150498 in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm SAAFEC_S1262.csv 11172 4750 2477 I1571V Fibronectin Homo sapiens 1.41 0.41 6.9 Unknown Sodium acetate 50 mM 25.0 CD GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 9.0 1TTF, 2CK2, 1FNF, 1TTG 14.207499980926514, 17.759999990463257, 20.274444368150498 in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 11173 4751 2477 Y1573A Fibronectin Homo sapiens 1.12 2.29 7.9 Unknown Sodium acetate 50 mM 25.0 CD GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 5.0 1TTF, 2CK2, 1FNF, 1TTG 18.208333333333332, 18.923333168029785, 24.75642830984933 in tunnel in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm SAAFEC_S1262.csv 12468 4751 2477 Y1573A Fibronectin Homo sapiens -2.65 2.0 Sodium acetate 50mM 25.0 Fluorescence GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 5.0 1TTF, 2CK2, 1FNF, 1TTG 18.208333333333332, 18.923333168029785, 24.75642830984933 in tunnel in pocket 18035373 10.1016/j.jmb.2007.10.056 2008 ProTherm 12467 5772 2477 Y1573F Fibronectin Homo sapiens -0.27 2.0 Sodium acetate 50mM 25.0 Fluorescence GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 5.0 1TTF, 2CK2, 1FNF, 1TTG 18.208333333333332, 18.923333168029785, 24.75642830984933 in tunnel in pocket 18035373 10.1016/j.jmb.2007.10.056 2008 ProTherm 12469 5773 2477 E1575A Fibronectin Homo sapiens -0.57 2.0 Sodium acetate 50mM 25.0 Fluorescence GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 6.0 1TTF, 2CK2, 1FNF, 1TTG 21.726666556464302, 29.31111102634006, 34.06599998474121 in pocket 18035373 10.1016/j.jmb.2007.10.056 2008 ProTherm 11174 4752 2477 F1585A Fibronectin Homo sapiens 1.14 2.16 6.8 Unknown Sodium acetate 50 mM 25.0 CD GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 5.0 1TTF, 2CK2, 1FNF, 1TTG 23.81250023841858, 25.930000066757202, 21.353333473205566 in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm SAAFEC_S1262.csv 11175 4753 2477 V1587A Fibronectin Homo sapiens 1.1 2.42 5.7 Unknown Sodium acetate 50 mM 25.0 CD GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 7.0 1TTF, 2CK2, 1FNF, 1TTG 20.298750162124634, 19.43250012397766, 24.40750002861023 in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm SAAFEC_S1262.csv 11176 4754 2477 A1594G Fibronectin Homo sapiens 1.04 2.81 7.1 Unknown Sodium acetate 50 mM 25.0 CD GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 7.0 1TTF, 2CK2, 1FNF, 1TTG 20.52916653951009, 24.074166774749756, 22.3849999109904 in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm SAAFEC_S1262.csv 11177 4755 2477 I1596A Fibronectin Homo sapiens 0.91 3.66 7.2 Unknown Sodium acetate 50 mM 25.0 CD GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 8.0 1TTF, 2CK2, 1FNF, 1TTG 16.94124984741211, 21.96250009536743, 31.572221544053818 in tunnel in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm SAAFEC_S1262.csv 12470 4755 2477 I1596A Fibronectin Homo sapiens -2.9 2.0 Sodium acetate 50mM 25.0 Fluorescence GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 8.0 1TTF, 2CK2, 1FNF, 1TTG 16.94124984741211, 21.96250009536743, 31.572221544053818 in tunnel in pocket 18035373 10.1016/j.jmb.2007.10.056 2008 ProTherm 11178 4756 2477 I1596V Fibronectin Homo sapiens 1.3 1.12 7.1 Unknown Sodium acetate 50 mM 25.0 CD GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 8.0 1TTF, 2CK2, 1FNF, 1TTG 16.94124984741211, 21.96250009536743, 31.572221544053818 in tunnel in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm SAAFEC_S1262.csv 11179 4757 2477 L1599A Fibronectin Homo sapiens 1.02 2.94 6.6 Unknown Sodium acetate 50 mM 25.0 CD GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 8.0 1TTF, 2CK2, 1FNF, 1TTG 15.802500128746033, 22.5625, 49.46999994913737 in tunnel in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm SAAFEC_S1262.csv 12471 4757 2477 L1599A Fibronectin Homo sapiens -4.56 2.0 Sodium acetate 50mM 25.0 Fluorescence GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 8.0 1TTF, 2CK2, 1FNF, 1TTG 15.802500128746033, 22.5625, 49.46999994913737 in tunnel in pocket 18035373 10.1016/j.jmb.2007.10.056 2008 ProTherm 11180 4758 2477 P1601A Fibronectin Homo sapiens 1.41 0.41 6.6 Unknown Sodium acetate 50 mM 25.0 CD GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 9.0 1TTF, 2CK2, 1FNF, 1TTG 15.712857110159737, 19.877142769949778, 63.94428634643555 in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 11181 4759 2477 V1603A Fibronectin Homo sapiens 1.37 0.67 6.12 Unknown Sodium acetate 50 mM 25.0 CD GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 6.0 1TTF, 2CK2, 1FNF, 1TTG 16.594285828726633, 15.987142971583776, 54.53499984741211 in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 11020 4678 2477 Y1605F Fibronectin Homo sapiens -2.03 yes Sodium acetate 50 mM 25.0 Fluorescence Urea 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 9.0 1TTF, 2CK2, 1FNF, 1TTG 14.93583345413208, 15.509999831517538, 44.902142660958425 in tunnel in pocket 10623553 10.1006/jmbi.1999.3360 2000 ProTherm 11182 4678 2477 Y1605F Fibronectin Homo sapiens 1.16 2.03 6.2 Unknown Sodium acetate 50 mM 25.0 CD GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 9.0 1TTF, 2CK2, 1FNF, 1TTG 14.93583345413208, 15.509999831517538, 44.902142660958425 in tunnel in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm 12472 4678 2477 Y1605F Fibronectin Homo sapiens -2.87 2.0 Sodium acetate 50mM 25.0 Fluorescence GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 9.0 1TTF, 2CK2, 1FNF, 1TTG 14.93583345413208, 15.509999831517538, 44.902142660958425 in tunnel in pocket 18035373 10.1016/j.jmb.2007.10.056 2008 ProTherm 11183 4760 2477 I1607A Fibronectin Homo sapiens 0.9 3.72 5.6 Unknown Sodium acetate 50 mM 25.0 CD GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 5.0 1TTF, 2CK2, 1FNF, 1TTG 15.820000103541783, 14.199999945504326, 25.664444393581814 in tunnel in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm SAAFEC_S1262.csv 11184 4761 2477 I1607V Fibronectin Homo sapiens 1.38 0.61 5.5 Unknown Sodium acetate 50 mM 25.0 CD GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 5.0 1TTF, 2CK2, 1FNF, 1TTG 15.820000103541783, 14.199999945504326, 25.664444393581814 in tunnel in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 11185 4762 2477 V1609A Fibronectin Homo sapiens 0.96 3.33 6.8 Unknown Sodium acetate 50 mM 25.0 CD GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 7.0 1TTF, 2CK2, 1FNF, 1TTG 20.630000114440918, 16.243749856948853, 20.512500047683716 in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm SAAFEC_S1262.csv 11186 4763 2477 A1611G Fibronectin Homo sapiens 1.26 1.38 6.2 Unknown Sodium acetate 50 mM 25.0 CD GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 9.0 1TTF, 2CK2, 1FNF, 1TTG 23.21333344777425, 19.016666730244953, 14.701666831970215 in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm SAAFEC_S1262.csv 8968 3867 2477 P1619A Fibronectin Homo sapiens 0.42 Unknown sodium acetate 50 mM 25.0 CD Urea 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 9.0 1TTF, 2CK2, 1FNF, 1TTG 47.487142835344585, 30.80285726274763, 37.49000058855329 in pocket 12054791 10.1016/S0022-2836(02)00184-5 2002 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 11187 4764 2477 S1622A Fibronectin Homo sapiens 1.49 -0.11 6.5 Unknown Sodium acetate 50 mM 25.0 CD GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 8.0 1TTF, 2CK2, 1FNF, 1TTG 20.00333372751872, 20.56833330790202, 20.556249856948853 in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 8969 3868 2477 P1624A Fibronectin Homo sapiens 0.21 Unknown sodium acetate 50 mM 25.0 CD Urea 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 6.0 1TTF, 2CK2, 1FNF, 1TTG 25.161428451538086, 23.96714292253767, 31.507143565586635 in pocket 12054791 10.1016/S0022-2836(02)00184-5 2002 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 11188 4765 2477 I1625A Fibronectin Homo sapiens 1.42 0.35 6.03 Unknown Sodium acetate 50 mM 25.0 CD GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 5.0 1TTF, 2CK2, 1FNF, 1TTG 20.816000366210936, 21.352000045776368, 19.455555597941082 in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 11189 4766 2477 I1625V Fibronectin Homo sapiens 1.42 0.35 6.5 Unknown Sodium acetate 50 mM 25.0 CD GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 5.0 1TTF, 2CK2, 1FNF, 1TTG 20.816000366210936, 21.352000045776368, 19.455555597941082 in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 11190 4767 2477 I1627A Fibronectin Homo sapiens 1.42 0.35 6.0 Unknown Sodium acetate 50 mM 25.0 CD GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 6.0 1TTF, 2CK2, 1FNF, 1TTG 20.28375005722046, 21.770000219345093, 35.51000001695421 in tunnel in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 11229 4767 2477 I1627A Fibronectin Homo sapiens 1.04 3.66 5.74 7.2 2.0 Sodium acetate 50mM 25.0 Fluorescence GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 6.0 1TTF, 2CK2, 1FNF, 1TTG 20.28375005722046, 21.770000219345093, 35.51000001695421 in tunnel in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm 11191 4768 2477 I1627V Fibronectin Homo sapiens 1.43 0.28 6.3 Unknown Sodium acetate 50 mM 25.0 CD GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 6.0 1TTF, 2CK2, 1FNF, 1TTG 20.28375005722046, 21.770000219345093, 35.51000001695421 in tunnel in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 11230 4768 2477 I1627V Fibronectin Homo sapiens 0.91 1.12 8.28 7.1 2.0 Sodium acetate 50mM 25.0 Fluorescence GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 6.0 1TTF, 2CK2, 1FNF, 1TTG 20.28375005722046, 21.770000219345093, 35.51000001695421 in tunnel in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm 11192 4769 2477 Y1629F Fibronectin Homo sapiens 1.49 -0.11 6.5 Unknown Sodium acetate 50 mM 25.0 CD GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 7.0 1TTF, 2CK2, 1FNF, 1TTG 13.472727342085404, 14.470909031954678, 61.35571561540876 in tunnel in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm SAAFEC_S1262.csv, SAAFEC_S983.csv 11193 4770 2477 Y1629A Fibronectin Homo sapiens 1.29 1.19 6.6 Unknown Sodium acetate 50 mM 25.0 CD GdnHCl 5.0 P02751 IPR050991:ECM_Regulatory_Proteins, IPR000083:Fibronectin_type1, IPR003961:FN3_dom, IPR036116:FN3_sf, IPR000562:FN_type2_dom, IPR036943:FN_type2_sf, IPR013783:Ig-like_fold, IPR013806:Kringle-like 7.0 1TTF, 2CK2, 1FNF, 1TTG 13.472727342085404, 14.470909031954678, 61.35571561540876 in tunnel in pocket 10986129 10.1006/jmbi.2000.4053 2000 ProTherm SAAFEC_S1262.csv 17479 302 157 Ribonuclease Bacillus amyloliquefaciens 135.0 yes(54%) 53.6 PIPES 0.01 M DSC Thermal 6.2 3.1.27.- P00648 IPR001887:Barnase, IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR053753:RNase_N1/T1-like_sf 7957933 10.1016/0014-5793(94)01127-3 1994 ProTherm 17480 302 157 Ribonuclease Bacillus amyloliquefaciens 128.0 yes(54%) 54.8 PIPES 0.01 M NaCl 0.05 M DSC Thermal 6.2 3.1.27.- P00648 IPR001887:Barnase, IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR053753:RNase_N1/T1-like_sf 7957933 10.1016/0014-5793(94)01127-3 1994 ProTherm 18007 302 157 Ribonuclease Bacillus amyloliquefaciens 128.5 128.4 yes (>95%) 51.5 Sodium acetate,Acetic acid, 6.08 mM,13.92 mM, DSC Thermal 4.4 3.1.27.- P00648 IPR001887:Barnase, IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR053753:RNase_N1/T1-like_sf 7831279 10.1093/protein/7.9.1089 1994 ProTherm 18008 302 157 Ribonuclease Bacillus amyloliquefaciens 127.5 128.7 yes (>95%) 51.63 Sodium acetate,Acetic acid, 6.08 mM,13.92 mM, DSC Thermal 4.4 3.1.27.- P00648 IPR001887:Barnase, IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR053753:RNase_N1/T1-like_sf 7831279 10.1093/protein/7.9.1089 1994 ProTherm 18128 302 157 Ribonuclease Bacillus amyloliquefaciens 125.0 yes (>85%) 53.9 MES 50 mM Fluorescence Thermal 6.3 3.1.27.- P00648 IPR001887:Barnase, IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR053753:RNase_N1/T1-like_sf 2669964 10.1021/bi00437a058 1989 ProTherm 18192 302 157 Ribonuclease Bacillus amyloliquefaciens 129.0 130.0 yes 54.5 Na-acetate 10 mM NaCl 0.05 M DSC Thermal 6.2 3.1.27.- P00648 IPR001887:Barnase, IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR053753:RNase_N1/T1-like_sf 10094494 10.1016/s0014-5793(99)00158-1 1999 ProTherm 18355 302 157 Ribonuclease Bacillus amyloliquefaciens 1.37 125.6 124.2 yes 54.3 acetate 10 mM DSC Thermal 5.8 3.1.27.- P00648 IPR001887:Barnase, IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR053753:RNase_N1/T1-like_sf 8003984 10.1002/pro.5560030414 1994 ProTherm 18737 302 157 Ribonuclease Bacillus amyloliquefaciens 82.5 yes 24.0 Potassium acetate 50 mM DSC Thermal 2.0 3.1.27.- P00648 IPR001887:Barnase, IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR053753:RNase_N1/T1-like_sf 8142395 10.1021/bi00179a018 1994 ProTherm 18738 302 157 Ribonuclease Bacillus amyloliquefaciens 94.3 yes 31.6 Potassium acetate 50 mM DSC Thermal 2.5 3.1.27.- P00648 IPR001887:Barnase, IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR053753:RNase_N1/T1-like_sf 8142395 10.1021/bi00179a018 1994 ProTherm 18739 302 157 Ribonuclease Bacillus amyloliquefaciens 107.4 yes 39.6 Potassium acetate 50 mM DSC Thermal 3.0 3.1.27.- P00648 IPR001887:Barnase, IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR053753:RNase_N1/T1-like_sf 8142395 10.1021/bi00179a018 1994 ProTherm 18740 302 157 Ribonuclease Bacillus amyloliquefaciens 118.9 yes 46.7 Potassium acetate 50 mM DSC Thermal 3.5 3.1.27.- P00648 IPR001887:Barnase, IPR000026:N1-like, IPR016191:Ribonuclease/ribotoxin, IPR053753:RNase_N1/T1-like_sf 8142395 10.1021/bi00179a018 1994 ProTherm 18741 302 157 Ribonuclease Bacillus amyloliquefaci