COURSE: Computational Approaches and In Silico Enzyme Library Design for Applied Biocatalysis
Groningen, The Netherlands, July 1-5, 2019
The course aims to make participants familiar with the use of structural biology and computational tools for engineering the performance of enzymes that are relevant for applied biocatalysis and synthetic biology. The course provides both a theoretical background on computational methods relevant to enzyme engineering (protein crystallography, homology modelling, energy calculations, protein design, smart libraries), and hands-on computer exercises on visualization and analysis of enzymes structures, including docking simulations and enzyme redesign. The theoretical and practical parts are integrated into a few problem-solving modules. Participants will have the opportunity to share their research via short oral presentations, posters, and interactive lectures.