Method of Detoxification of Yperite by using Haloalkane Dehalogenases
Prokop, Z., Damborsky, J., Oplustil, F., Jesenska, A., Nagata, Y.
Masaryk University, Žerotínovo nám. 9, 601 77 Brno, Czech Republic
CZ Patent 298287
Date of submission
Date of publication
The method of detoxification of yperite by the use of haloalkane dehalogenases or their compositions, the method of preparation of dehalogenationating enzymes and of decontamination compositions which contain at least one wild type and/or modified haloalkane dehalogenase (EC 188.8.131.52) as an chemically active component. The preferred dehalogenases are DhaA from Rhodococcus rhodochrous NCIMB 13064, DmbA from Mycobacterium bovis 5033/66 or LinB from Sphingomonas paucimobilis UT26. Decontamination is utilized for detoxification of yperite from the surfaces of instrumentality, constructional objects, the people’s or animal’s skin and elements of environment, when yperite is exposed to the action of decontamination composition at +10 °C to +70 °C, preferably at +40 °C and pH = 4 to 12.