Method of Detoxification of Yperite by using Haloalkane Dehalogenases
Authors
Prokop, Z., Damborsky, J., Oplustil, F., Jesenska, A., Nagata, Y.
Applicant
Masaryk University, Žerotínovo nám. 9, 601 77 Brno, Czech Republic
Application number
WO 2006/128390 A1
Date of submission
2005-06-03
Date of publication
2007-08-15
Abstract
The method of detoxification of yperite by the use of haloalkane dehalogenases or their compositions, the method of preparation of dehalogenationating enzymes and of decontamination compositions which contain at least one wild type and/or modified haloalkane dehalogenase (EC 3.8.1.5) as an chemically active component. The preferred dehalogenases are DhaA from Rhodococcus rhodochrous NCIMB 13064, DmbA from Mycobacterium bovis 5033/66 or LinB from Sphingomonas paucimobilis UT26. Decontamination is utilized for detoxification of yperite from the surfaces of instrumentality, constructional objects, the people’s or animal’s skin and elements of environment, when yperite is exposed to the action of decontamination composition at +10 °C to +70 °C, preferably at +40 °C and pH = 4 to 12.