Method of Detoxification of Yperite by using Haloalkane Dehalogenases

Authors

Prokop, Z., Damborsky, J., Oplustil, F., Jesenska, A., Nagata, Y.

Applicant

Masaryk University, Žerotínovo nám. 9, 601 77 Brno, Czech Republic

Application number

CZ Patent 298287

Date of submission

2005-06-03

Date of publication

2007-08-15

Abstract

The method of detoxification of yperite by the use of haloalkane dehalogenases or their compositions, the method of preparation of dehalogenationating enzymes and of decontamination compositions which contain at least one wild type and/or modified haloalkane dehalogenase (EC 3.8.1.5) as an chemically active component. The preferred dehalogenases are DhaA from Rhodococcus rhodochrous NCIMB 13064, DmbA from Mycobacterium bovis 5033/66 or LinB from Sphingomonas paucimobilis UT26. Decontamination is utilized for detoxification of yperite from the surfaces of instrumentality, constructional objects, the people’s or animal’s skin and elements of environment, when yperite is exposed to the action of decontamination composition at +10 °C to +70 °C, preferably at +40 °C and pH = 4 to 12.

Full application EN •  Full application CZ

Citation

Prokop, Z., Damborsky, J., Oplustil, F., Jesenska, A., Nagata, Y., 2005: Method of Detoxification of Yperite by using Haloalkane Dehalogenases. Masaryk University, Brno, Czech Republic. Patent WO 2006/128390 A1.

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