Gates of Enzymes

Authors

Gora, A., Brezovsky, J., Damborsky, J.

Source

CHEMICAL REVIEWS 113: 5871–5923 (2013)

Abstract

The Gates of EnzymesThis review highlights the importance of gates in enzymes. The gates control substrate access to the active site and product release, restrict solvent access to specific protein regions, and synchronize processes occurring in distinct parts of the enzyme. Survey of 129 gates in 71 enzymes enabled a rigorous definition of gates and establishment of a new scheme for their classification. Gates were assigned to six distinct classes – wings, swinging doors, apertures, drawbridges, double drawbridges and shells. Presented are summary statistics describing the propensity of specific amino acid residues in particular gate classes. The proposed classification scheme provides guidance for the analysis and engineering of gates in biomolecular systems.

Citation

Gora, A., Brezovsky, J., Damborsky, J., 2013: Gates of Enzymes. Chemical Reviews 113: 5871–5923.

Open Ph.D. Position: Microfluidics
Summer School of Protein Engineering
2nd Hands-on Computational Enzyme Design Workshop
J. Heyrovsky Award for Hana and Martin
LL Article in Spotlight on Science
Success in MUNI Scientist Award
iGEM Gold Medal for Generation Mendel