Research Infrastructure
Computer Modelling
Hardware
- 22 nodes, 2x 10-core Intel Xeon, 378 GB RAM, 2x NVIDIA K2 GPU, 300 GB HDD
- 7 nodes, 2x 8-core Intel Xeon, 128 GB RAM, 1200 GB HDD
- 12 nodes, 6-core Intel Xeon, 12 GB RAM, 600 GB HDD
- 2 nodes, 48-core AMD Opteron, 32 GB RAM, 600 GB HDD
- Oculus Rift virtual reality headset
Software
- AMBER, University of California, San Francisco, USA
- AUTODOCK, The Scripps Research Institute, La Jolla, USA
- BIOEDIT, North Carolina State University, Raleigh, USA
- CAVER, CaverSoft, Czech Republic
- CHARMM, Harvard University, Cambridge, USA
- DOCK, University of California, San Francisco, USA
- FOLD-X, European Molecular Biology Laboratory, Germany
- GAMESS-UK, Daresbury Laboratory, Daresbury, UK
- GAUSSIAN, Gaussian, Inc., Carnegie, USA
- MODELLER, University of California, San Francisco, USA
- MOPAC, Fujitsu Ltd., Japan
- ROSETTA, University of Washington, Seattle, USA
- SIMCA, Umetrics, Umea, Sweden
- STATISTICA, StatSoft, Inc., Tulsa, USA
- TRITON, Masaryk University, Brno, Czech Republic
- VECTOR NTI, Emory University, Atlanta, USA
- WHATIF, the University of Nijmegen, The Netherlands
Molecular Biology
Laboratory of Molecular Biology
- Electroporator ECM 399 Generator, BTX, Canada
- Rapid Translation System ProteoMaster, Roche, France
- Biohazard BoxBioban 48, Steril, Italy
- Biohazard Box Safe Fast Light
- Biological Thermostat BT 120M, Laboratory equipment Prague, Czech Republic
- Max Pro Thermal Cycler, Esco Healthcare Ltd., UK (2x)
- Block Heater HB-1, Wealtec Corp., USA
- Dry Bath Incubator, Major Science, USA
- Centrifuge Mikro 120, Hettich, Germany
- Centrifuge Mikro 20, Hettich, Germany
- Centrifuge Cooled Micro 200R, Hettich, Germany
- Concentrator centrifuge DNA 120-230 SpeedVac, Thermo, USA
- Vibrax VRX Basic, IKA Laboratory Equipment, Germany
Laboratory of Robotic Screening and Protein Purification
- Colony Picking Robot CP7200, Norgren System, USA
- Liquid Handling Robot Microlab StarLet Manuload, Hamilton, USA
- Microplate Reader Tecan Sunrise, Tecan, Switzerland
- Microplate Reader FLUOstar OPTIMA, BMG Labtech, Germany
- FPLC BioLogic DuoFlow, Bio-Rad, USA (2x)
- FPLC Akta Purifier 10, GE Healthcare, USA (2x)
- Shaking Water Bath GLS Aqua Plus, Grant Instruments, UK (3x)
Enzymology and Microbiology
Laboratory of Fermentations
- Bioreactor Biostat B Plus (vessel 1 and 2, 1.0 L), Sartorius Stedim, Germany
- Bioreactor Labfors 3 (7.5 L), Infors HT, Switzerland
- Bioreactor Labfors 3 (2.0 L), Infors HT, Switzerland
- Mini-PROTEAN Tetra Electrophoresis System, Bio-Rad, USA
- Sub-Cell GT Agarose Gel Electrophoresis System, Bio-Rad, USA
- BioDoc-It 220 Imaging System UVP with transilluminator M-26r, UVP, USA
- Gel Dryer Cleaver, Cleaver Scientific, UK
- Biological microscope LMI B, Intraco Micro, Czech Republic
- Stereomicroscope STM 701, Intraco Micro, Czech Republic
Technology Room
- Sonic Dismembrator FB705, Fisher Scientific, USA
- Ultrasonic Processor, Hielscher UP200S, Germany
- Select Neptune Ultimate, Milli Q water, Purite Ltd., UK
- Centrifuge 6K15, SIGMA Laborzentrifugen, Germany
- Centrifuge 6K16, SIGMA Laborzentrifugen, Germany (2x)
- Centrifuge 2-16K, SIGMA Laborcentrifugen, Germany
- High-Performance Centrifuge Avanti J-30I, Beckman Coulter, USA
- Ultralow Temperature Freezer Innova U725, New Brunswick Scientific, USA
- Orbital Incubator Innova 44, New Brunswick Scientific, USA (3x)
- Freeze Dryer ALPHA 1-2 LD, Martin Christ, Germany
- Freeze Dryer Scanvac CoolSafe, Labogene, Denmark
- Ice Flaker GB 902, Brema Ice Makers, Italy
- Shaking Incubator NB-205, N-Biotek Inc., South Korea (3x)
- Thermal Incubator MIR-262, Sanyo, Japan
- pH meter CyberScan pH1500, Eutech Instruments, USA
- Analytical Balances AP-225V, Phoenix Instrument, Germany
- Balances ACB-300, Adam Equipment, UK
- Precision Electronic Balance HR120, A&D, Japan
Washing Room
- Autoclave, Tuttnauer 2540EL, The Netherlands
- Autoclave, Tuttnauer 5075 ELVC, The Netherlands
- Autoclave MLS-3780 78L, Sanyo, Japan
- Autoclave MLS-3781 78L, Sanyo, Japan
- Dish Washer Miele G7883CD, Miele, Germany
- Drying Owen MOV-212, Sanyo, Japan
Laboratory of Enzyme Kinetics
- Isothermal Titration Calorimeter VP-ITC, GE Healthcare, USA
- Differential Scanning Microcalorimeter VP-Capillary DSC, GE Healthcare, USA
- Gel permeation chromatography system with tetra detection (UV, IR, refractive index, RALS/LALS), Malvern, UK
- Microplate Reader Synergy H4, BioTek, USA
- Rapid Quench-Flow, QFM-400, Biologic, France
- Shaker GFL 3006, GFL, Germany
- Spectrophotometer Ultrospec 1000, Pharmacia Biotech, Sweden
- Spectrophotometer Biomate 3S, Thermo Scientific, USA
- Spectropolarimeter Chirascan, Applied Photophysics, UK
- Spectrofluorometer FloroMax-4, HORIBA Jobin Yvon, France
- Stopped-Flow SFM-300/MOS-200 (UV-VIS, fluorescence, anisotropy, t-Jump), Biologic, France
- Stopped-Flow SFM-300/MOS-500 (UV-VIS, circular dichroism, fluorescence, anisotropy), Biologic, France
- UNcle with fluorescence, SLS and DLS mode, Unchained Lab, USA
- Thermostatic Water Bath GLS400 (shaking), Grant, UK
- Thermostatic Water Bath OLS200 (shaking) with a cooling system, Grant, UK
- Thermostatic Water Bath GLS Aqua 18 Plus (shaking), Grant, UK
- Vacuum Rotavapor R-215 Professional, Buchi Labortechnik, Switzerland
- Vacuum Pump V-700, Buchi Labortechnik, Switzerland
- Vacuum Controller V-855, Buchi Labortechnik, Switzerland
- Crystal Gryphon,ARI – Art Robbins Instruments, USA
Chromatography
Laboratory of Gas and Liquid Chromatography
- Analytical Autocalibrated Balance, Adam AAA 160L, UK
- Gas Chromatograph 6890N (GC-2xFID), Agilent, USA
- Gas Chromatograph 7890A CTC sampler (GC-2xFID), Agilent, USA
- HPLC 1100 (UV-VIS, RID), Agilent, USA
- HPLC-IC, ICS-5000+, Thermo/Dionex, USA
- Mass Spectrometer 5975C MSD and Gas Chromatograph 7890A (GC-MS), Agilent, USA
- GC-MS Trace Ultra ISQ, Robotic sampler TriPlus RSH, The Thermo Scientific, USA
- Capillary electrophoresis, NEXT, Prince Technologies, The Netherlands
Laboratory of Microfluidics
- Mitos Dropix, Dolomite, United Kingdom
- Plasma system FEMTO, Diener, Germany
- IX51 Inverted Microscope, Olympus, Japan
- Fluorescence microscope MVX 10, Olympus, Japan
- 3D laser scanning microscope Lext OLS4100, Olympus, Japan
- i-SPEED TR camera, Olympus, Japan
- Fusion 200 syringe pumps, Chemyx, USA
- neMESYS low-pressure syringe pump system, Cetoni, Germany
- Microfluidic flow control system, Elveflow, France
- Puncher, Accu-Punch MP-10-UNV, Syneo, USA
- Spin Coater WS-650-23, Laurell Technologies Corporation, United Kingdom
- High-Performance SLA DLP 3D Printer Titan 2, Kudo3D, USA
- Laser engraver RayJet 50, Trotec Laser, Austria
- Capillary-based Microfluidic Platform, in-house
Computational Tools for Structural Biology
- A Linux-based workstation equipped with Nvidia 3D vision kit including 3D vision glasses
- XDS package for processing, indexing and merging crystallographic data (MPI, Heidelberg, Germany)
- iMOSFL package for processing, indexing and merging crystallographic data (MRC, Cambridge, UK)
- CCP4 suite with many useful tools/software for macromolecular crystallography (STFC Daresbury Laboratory, Warrington, UK)
- PHENIX: software for automated determination of molecular structures (University of California, Berkeley, USA)
- COOT: manual model building and interpretation of electron density maps (MRC, Cambridge, UK)