{"id":2863,"date":"2015-10-16T15:31:26","date_gmt":"2015-10-16T15:31:26","guid":{"rendered":"http:\/\/loschmidt.chemi.muni.cz\/peg\/?page_id=2863"},"modified":"2018-05-25T09:24:34","modified_gmt":"2018-05-25T09:24:34","slug":"calfitter","status":"publish","type":"page","link":"https:\/\/loschmidt.chemi.muni.cz\/peg\/software\/calfitter\/","title":{"rendered":"CalFitter"},"content":{"rendered":"<p><strong>This is now a standalone version of the software tool. An up-to-date version has been released and can be found<\/strong> <a href=\"https:\/\/loschmidt.chemi.muni.cz\/calfitter\/\" rel=\"noopener\" target=\"_blank\">here<\/a>.<\/p>\n<p><img decoding=\"async\" class=\"alignright size-medium wp-image-3364\" style=\"margin-top: 22px;\" src=\"http:\/\/loschmidt.chemi.muni.cz\/peg\/wp-content\/uploads\/2015\/10\/calfitter_logo-300x71.png\" alt=\"CalFitter\" width=\"220\" srcset=\"https:\/\/loschmidt.chemi.muni.cz\/peg\/wp-content\/uploads\/2015\/10\/calfitter_logo-300x71.png 300w, https:\/\/loschmidt.chemi.muni.cz\/peg\/wp-content\/uploads\/2015\/10\/calfitter_logo-515x122.png 515w, https:\/\/loschmidt.chemi.muni.cz\/peg\/wp-content\/uploads\/2015\/10\/calfitter_logo.png 1024w\" sizes=\"(max-width: 300px) 100vw, 300px\" \/><br \/>\n<strong>CalFitter<\/strong> is a newly developed computational tool for analysis and fitting of calorimetric protein melting curves obtained from differential scanning calorimetry (DSC) measurements. The application allows simultaneous global fitting with various scan rates and reheating using 10 different models of unfolding. Apart from the heat capacity curve, each model provides population of intermediates versus temperature, fitted parameter values, and respective confidence intervals of the fitting. The program provides a means to export the analysis into Excel as well.<\/p>\n<p>The user guide can be downloaded <a href=\"http:\/\/loschmidt.chemi.muni.cz\/peg\/wp-content\/uploads\/2015\/10\/User-guide-Calfitter.pdf\" target=\"_blank\" rel=\"noopener\">here<\/a>. The application is coded in MATLAB. If MATLAB is already installed on your computer, download <a href=\"http:\/\/loschmidt.chemi.muni.cz\/peg\/wp-content\/uploads\/2015\/10\/CalFitter_MATLAB.zip\">the application source files<\/a> and run <code>CalFitter.m<\/code> from your MATLAB. Otherwise, MATLAB runtime is required (minimal required version is 8.4\/R2014b), which can be installed in several ways:<\/p>\n<ul>\n<li>via a web-based application <code>MATLAB_runtime_web.exe<\/code> in <a href=\"http:\/\/loschmidt.chemi.muni.cz\/peg\/wp-content\/uploads\/2015\/10\/CalFitter_runtime_web.zip\">distribution archive<\/a> or<\/li>\n<li>by downloading it from the <a href=\"http:\/\/www.mathworks.com\/products\/compiler\/mcr\/index.html\" target=\"_blank\" rel=\"noopener\">official website<\/a>.<\/li>\n<\/ul>\n<p>As soon as the installation of the MATLAB runtime is completed, run <code>CalFitter.exe<\/code> from either of the above archives.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-large wp-image-2872\" src=\"http:\/\/loschmidt.chemi.muni.cz\/peg\/wp-content\/uploads\/2015\/10\/CalFitter-515x404.png\" alt=\"CalFitter\" width=\"515\" height=\"404\" srcset=\"https:\/\/loschmidt.chemi.muni.cz\/peg\/wp-content\/uploads\/2015\/10\/CalFitter-515x404.png 515w, https:\/\/loschmidt.chemi.muni.cz\/peg\/wp-content\/uploads\/2015\/10\/CalFitter-300x235.png 300w, https:\/\/loschmidt.chemi.muni.cz\/peg\/wp-content\/uploads\/2015\/10\/CalFitter.png 1250w\" sizes=\"auto, (max-width: 515px) 100vw, 515px\" \/><\/p>\n<p>Please, cite the following article whenever you use the <strong>CalFitter<\/strong> in your research:<br \/>\nMazurenko S., Kunka A., Beerens K., Johnson C. M., Damborsky J., Prokop Z., 2017: <a href=\"https:\/\/loschmidt.chemi.muni.cz\/peg\/publications\/exploration-of-protein-unfolding-by-modelling-calorimetry-data-from-reheating\/\">Exploration of Protein Unfolding by Modelling Calorimetry Data from Reheating<\/a>. <strong>Scientific Reports<\/strong> 7, Article&nbsp;no.:&nbsp;<span data-test=\"article-number\">16321.&nbsp;<\/span>DOI: 10.1038\/s41598-017-16360-y.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>This is now a standalone version of the software tool. An up-to-date version has been released and can be found here. CalFitter is a newly developed computational tool for analysis and fitting of calorimetric protein melting curves obtained from differential scanning calorimetry (DSC) measurements. The application allows simultaneous global fitting with various scan rates and [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":2445,"menu_order":22,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ngg_post_thumbnail":0,"footnotes":""},"class_list":["post-2863","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/loschmidt.chemi.muni.cz\/peg\/wp-json\/wp\/v2\/pages\/2863","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/loschmidt.chemi.muni.cz\/peg\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/loschmidt.chemi.muni.cz\/peg\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/loschmidt.chemi.muni.cz\/peg\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/loschmidt.chemi.muni.cz\/peg\/wp-json\/wp\/v2\/comments?post=2863"}],"version-history":[{"count":26,"href":"https:\/\/loschmidt.chemi.muni.cz\/peg\/wp-json\/wp\/v2\/pages\/2863\/revisions"}],"predecessor-version":[{"id":4916,"href":"https:\/\/loschmidt.chemi.muni.cz\/peg\/wp-json\/wp\/v2\/pages\/2863\/revisions\/4916"}],"up":[{"embeddable":true,"href":"https:\/\/loschmidt.chemi.muni.cz\/peg\/wp-json\/wp\/v2\/pages\/2445"}],"wp:attachment":[{"href":"https:\/\/loschmidt.chemi.muni.cz\/peg\/wp-json\/wp\/v2\/media?parent=2863"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}