Sergio Manuel Marques, Dr.

Sergio Manuel Marques, Dr.

Organic and Computational Chemistry
since 2013

Info MU

Research interests

Sérgio Marques’ main research topic is focused on utilizing molecular modelling tools for protein engineering. He is working on several projects involving the optimization of various properties of enzymes (e.g., haloalkane dehalogenases and dioxygenases) for different practical purposes. He also collaborates with other research groups to understand the catalytic properties of their proteins of interest or design improved variant using computational biology methods. More recently, Sérgio Marques has been involved in applying computational methods for understanding the mechanisms of Alzheimer's disease at the molecular level and the protective effects of small molecules.


2007 PhD, Chemistry, Instituto Superior Técnico, Technical University of Lisbon, Lisbon, Portugal
2002 MSc, Chemical Engineering, Instituto Superior Técnico, Technical University of Lisbon, Lisbon, Portugal

Research stays

2016 Prof. Michele Parrinello’s group, ETH Zurich (Lugano, Switzerland)
2009 Prof. Adriano Martinelli’s group, University of Pisa (Pisa, Italy)
2007-2008 Prof. Armando Rossello’s group, University of Pisa (Pisa, Italy)
2004 Prof. Claudiu Supuran’s group, University of Florence (Florence, Italy)


Hands-on Computational Enzyme Design Course (2020-now)
Structural Biology and Bioinformatics (2021-now)
Structural Biology (2017-now)

Scientific output

56 research articles
>1,356 citations
H-index 23



Martin Toul Won Doctorandus Prize of the Czech Head Award
Martin Toul Received the Award of the Ministry of Education, Youth and Sports for Outstanding Students
David Presented at ELIXIR 3D-BioInfo conference
2nd Place in the Competition of Transfera Technology Day 2023
Martin to Be a Chairperson at the 34th European Crystallography Congress 2024
Vice-Rector’s Award for Martin Toul
Veronika Presented at the 15th World Stroke Congress