The Future for the Application of Fibroblast Growth Factor 2 in Modern Wound Healing
Authors
Holoubek, J., Lipovy, B., Knoz, M., Kempny, T., Chaloupkova, R., Damborsky, J., Vojtova, L.
Source
BURNS 49: 484-486 (2023)
Abstract
Representatives of the fibroblast growth factor (FGF) family regulate a wide range of biological functions important for every phase of wound healing, such as cell proliferation, migration, and differentiation. The name of the family is derived from the primary assumption that FGF proteins (FGF1 and FGF2) are important for promoting fibroblast migration and proliferation. Today, FGFs are known to intervene in a wide range of biological functions of various cell populations.
Their function is mediated by binding to specific receptors (tyrosine-kinase receptors), which leads to their activation and transmembrane signal transduction into the cell [1]. Based on sequence similarities, biochemical functions and their own activity, the individual representatives of the FGF family were divided into seven subgroups (subfamilies). The FGF1 subfamily (composed of FGF1 and FGF2) plays a key role in the healing and regeneration processes. Damaged macrophages and endothelial cells at the site of injury release FGF2 and FGF1, thereby directly influencing the healing process; FGF2 then plays a key role also in the scarless healing process, which makes it potentially useful in regenerative medicine) [2].