热稳定性FGF2多肽、其用途 (Thermostable FGF2 Polypeptide, Use Thereof)
Authors
Dvorak, P., Krejci, P., Balek, L., Eiselleova, L., Konecna, Z., Dvorak, P., Bednar, D., Brezovsky, J., Sebestova, E., Chaloupkova, R., Stepankova, V., Vanacek, P., Prokop, Z., Damborsky, J., Bosakova, M.
Applicant
Masaryk University and Enantis, s.r.o., Brno, Czech Republic
Application number
CN108779158B
Date of submission
2016-10-03
Date of publication
2026-05-01
Abstract
This invention provides isolated thermostable peptides and their uses in cell biology research, regenerative medicine and related medical applications or cosmetics, wherein the thermostable peptides have FGF2 activity and at least 85% sequence identity with SEQ ID NO:2 (FGF2wt) or its functional fragment and contain at least one amino acid substituted for R31L. In addition, a culture medium containing the aforementioned FGF2 is disclosed, which is suitable for culturing human pluripotent stem cells involving both human embryonic stem cells and induced pluripotent stem cells.