Diploma Theses

Name Thesis
Kohout Petr Identification of the Protein Tunnels using Molecular Dynamics (Department of Information Systems, FIT VUT, 2020-2022)
Kohout Pavel Application of Variational Autoencoders for Ancestral Sequence Reconstruction (Department of Computer Systems, FIT VUT, 2020-2022)
Bubenik Michal Machine-Learning based Prediction of Substrate Specificity Profiles for Haloalkane Dehalogenases (RECETOX, 2020-2022)
Slanska Michaela Kinetic Mechanism of Fluorinase from Bacterium Streptomyces sp. MA37 (Department of Biochemistry, 2020-2022)
Slanska Katerina Study of Protein Solubility (Department of Molecular Biology and Genetics, 2019-2021)
Horackova Jana Prediction of Stable Proteins (Department of Biochemistry, 2019-2021)
Dobias Adam PredictSNP Onco: Web Server for Automatic Analysis of Oncology-Based Mutations (Department of Biochemistry, 2018-2021)
Velecky Jan Prediction of the Effect of Mutation on Protein Solubility Using Electrostatic Potential (Department of Computer Systems, FIT VUT, 2018-2020)
Vasina Michal High-throughput Characterization of Novel Biocatalysts by Using Microfluidics (Department of Biophysical Chemistry, 2017-2019)
Solansky Pavel Application of Microfluidics in Metabolic Engineering (Department of Molecular Biology and Genetics, 2016-2018)
Toul Martin Kinetic Mechanism of Coelenterazine-Dependent Luciferase Reaction (Department of Biochemistry, 2016-2018)
Dockalova Veronika Development of Fluorescent Substrates for Enzymology (Department of Biophysics, 2016-2018)
Dunajova Zuzana Computational Engineering of Enzymes with Buried Active Sites (Department of Structural Chemistry, 2015-2018)
Markova Klara Structural and Functional Characterization of Selected Haloalkane Dehalogenase Variants (Department of Special Biology, 2016-2018)
Stourac Jan Software Tool for Automated Design of Mutations and Smart Libraries for Protein Engineering (Department of Bioinformatics, 2015-2017)
Vavra Ondrej Methods for Identification of Biologically Relevant Tunnels in Proteins (Department of Genomics and Proteomics, 2015-2017)
Kunka Antonin Structural Base of Protein Stabilisation (Department of Biochemistry, 2014-2016)
Musil Milos Predictor of the Effect of Amino Acid Substitutions on Protein Function (Department of Information Systems, Brno University of Technology, 2014-2015)
Szelcsanyiova Petra Biochemical Characterization of Haloalkane Dehalogenases with Modified Tunnels (Department of Microbiology, 2012-2014)
Buryska Tom Development of Dehalogenase Inhibitors – Potential Antituberculotics (Department of Biochemistry, 2011-2013)
Neuwirth Ondrej Development of Inhibitors of Dehalogenases – Potential Antituberculotics (Department of Biochemistry, 2010-2013)
Chrast Lukas Characterization of Novel Biocatalysts from Extremophilic Bacteria (Department of Microbiology and Molecular Biotechnology, 2010-2012)
Drienovska Ivana Biochemical Characterization of the First Haloalkane Dehalogenase DpcA Isolated From Extremophilic Organism (Department of Biochemistry, 2011-2012)
Daniel Lukas In Silico Study of Substrate Specificity of Haloalkane Dehalogenases (Department of Biochemistry, 2009-2011)
Wolny Rostislav Developement of Bioinformatics Server (Faculty of Informatics, 2008-2010)
Dvorak Pavel Directed Evolution of Haloalkane Dehalogenase DhaA towards Increased
Activity with 1,2-dichloroethane (Department of Microbiology, 2008-2009)
Polinek Jiri Fermentative Production of Haloalkane Dehalogenases (Department of Microbiology, 2008-2009)
Pavelka Antonin HotSpot
Wizard – Tool for Selection of Protein Engineering Hot Spots (Faculty of Informatics, 2007-2008)
Stepankova Veronika Medium Engineering of Haloalkane Dehalogenase Catalysis: Effect of Water-Miscible Organic Solvents (Department of Biochemistry, 2005-2008)
Holub Peter Protein Engineering of Haloalkane Dehalogenase LinB: Towards the Change of Reaction Mechanism (Department of Biochemistry, 2006-2008)
Jerabek Petr Molecular Modeling of Enantioselectivity of Haloalkane Dehalogenase LinB (Department of Biochemistry, 2005-2007)
Bidmanova Sarka Development and Construction of Biosensors for Detection of Halogenated Compounds in the Environment (Department of Microbiology, 2005-2007)
Brezovsky Jan Computer-Assisted Study of Enzymatic Dehalogenation of DDT (Department of Biophysics, 2005-2006)
Klvana Martin Computer Modelling of Bacterial Enzymes Involved in Degradation of Halogenated Hydrocarbons (Department of Microbiology, 2002-2004)
Tesinska Iva Mycobacterial Haloalkane Dehalogenases Rv2296 and Rv2579 (Department of Biochemistry, 2002-2004)
Dobes Petr Structure-Function Characterization of the Elicitin Cryptogein (Department of Biochemistry, 2001-2003)
Budova Martina Exprese, purifikace a kineticka charakterizace haloalkan dehalogenas (Department of Biochemistry, 2001-2002)
Jedlicka Tomas Pocitacove modelovani enzym-substrat komplexu haloalkan dehalogenaz (Department of Environmental Sciences and Ecotoxicology, 2000-2003)
Strouhal Michal Screening of Genes rv2579, rv2296 and dhmA in Isolates of M. bovis, M. avium a M. paratuberculosis (Department of Microbiology, 2000-2003)
Monincova Marta Study of Kinetics of Microbial Dehalogenation Reactions (Department of Microbiology, 2000-2002)
Marvanova Sona Biochemical Characterization of Mutant Haloalkane Dehalogenases (Department of Environmental Sciences and Ecotoxicology, 1999-2001)
Czernekova Vladka Purification of Dehalogenase from Bacterium Mycobacterium avium (Department of Biochemistry, 1999-2001)
Slanina Michal Hydrolytic Dehalogenation of Unsaturated Aliphatic Hydrocarbons (Department of Environmental Sciences and Ecotoxicology, 1998-1999)
Bohac Michal Computer Modelling of Dehalogenation Reactions of Haloalkane Dehalogenases (Department of Environmental Sciences and Ecotoxicology, 1997-2000)
Prokop Martin TRITON – Visualization Software for Study of Enzymatic Reactions (Department of Organic Chemistry, 1995-1997)
Hynkova Kamila Estimation of Steady-State Constants of Haloalkane Dehalogenase LinB for Group of Halogenated Hydrocarbons (Department of Environmental Sciences and Ecotoxicology, 1995-1997)
Jesenska Andrea Study of Structure-Biodegradability Relationships for Halogenated Aliphatic Hydrocarbons (Department of Microbiology, 1995-1997)
Blaha Ludek Applications of Bioluminiscence Test (Department of Microbiology, 1994-1996)

Vesicles Mimicking Neuron Plasma Membranes Successfully Produced
4th Hands-on Computational Enzyme Design Workshop
Mystery of Renilla-type Luciferases Solved
New Baby in LL
PredictSNP Onco: Towards Personalized Medicine in Children’s Oncology
Merry Christmas and Happy New Year
Four LL Students Awarded Brno PhD Talent